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Rozprawy doktorskie na temat „Immunotoxicity”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Karrow, Niel. "Chemical mixture immunotoxicity to rainbow trout." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0005/NQ44769.pdf.

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Bartlett, Alison. "QSAR study of immunotoxicity in antibiotics." Thesis, Liverpool John Moores University, 1995. http://researchonline.ljmu.ac.uk/5135/.

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Since their inception the B-Iactam antibiotics have become one of the most important classes of phannaceutical agents, both therapeutically and economically, in modern day usage for the treatment of a wide spectrum of bacterial infections. However, due to the versatility of bacteria many previously treatable species are developing resistance to the antibiotics currently available and so there is ever a need to develop more ~-lactam antibiotics, which are effective and yet safe. A major drawback to the ~-lactams is the degree of immunologically adverse reactions they induce. It was the aim of t

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McDonald, Valerie Alexandra. "Evaluating Immunotoxicity of Quaternary Ammonium Compounds." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/79723.

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Alkyl dimethyl benzyl ammonium chloride (ADBAC) and didecyl dimethyl ammonium chloride (DDAC) are common quaternary ammonium compounds used as disinfectants in households, medical, and restaurant settings. They cause occupational skin and respiratory hazards in humans, and developmental and reproductive toxicity in mice. They also cause increased secretions of proinflammatory cytokines in cell lines and vaginal inflammation in porcine models; but have not been evaluated for developmental immunotoxicity. We assessed immunotoxicity in-vitro with J774A.1 murine macrophage cell line by analyzing c

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4

Maliji, Ghorban. "Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319022.

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McDonald, Jennifer C. Venables Barney J. "Bacterial challenge in Lumbricus terrestris a terrestrial invertebrate immunotoxicity model /." [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-3640.

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6

Baken, Kirsten Annika. "Immunotoxicogenomics gene expression profiling as a tool to study immunotoxicity /." [Maastricht] : Maastricht : Universitaire Pers Maastricht ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=9329.

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7

Rabideau, Christine L. "Pesticide Mixtures Induce Immunotoxicity: Potentiation of Apoptosis and Oxidative Stress." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/34547.

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The three insecticides of interest were lindane (an organochlorine), malathion (an organophosphate) and piperonyl butoxide (PBO; a synergist). Based on minimum cytotoxicity (> LC25), the following concentrations were chosen for the pesticide mixture studies: 70Î¼M lindane (Lind), 50Î¼M malathion (Mal) and 55Î¼M PBO. In the AlamarBlue cytotoxicity assay, individual pesticide and mixtures of malathion/PBO (MP) and malathion/lindane (ML) prompted cytotoxicity with varying intensities (Mal 18.8%, Lind 20.4%, PBO 23.5%, ML 53.6% and MP 64.9%). Cytopathological analysis revealed apoptotic feature

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8

Olgun, Selen. "Immunotoxicity of Pesticide Mixtures and the Role of Oxidative Stress." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/11114.

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The immunotoxic effects of multiple pesticide exposure were evaluated. C57BL/6 mouse thymocytes were exposed to lindane, malathion, and permethrin, either separately or in mixtures of two pesticides, in concentrations ranging from 37.5 uM to 1mM. These exposures caused both apoptotic and necrotic cell death in thymocytes as evaluated by 7-aminoactinomycin-D, Annexin-V/PI, and lactate dehydrogenase release assays. When cells were exposed to lindane+malathion, or lindane+permethrin, a significantly greater-than-additive cytotoxicity was observed. The pesticide exposure caused DNA ladder formatio

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9

McDonald, Jennifer C. "Bacterial Challenge in Lumbricus Terrestris: A Terrestrial Invertebrate Immunotoxicity Model." Thesis, University of North Texas, 2007. https://digital.library.unt.edu/ark:/67531/metadc3640/.

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A bacterial challenge assay was developed utilizing the earthworm, Lumbricus terrestris, in order to assess potential immunotoxic effects from exposure to specific polychlorinated biphenyl congeners. Earthworms were inoculated with Aeromonous hydrophila, establishing a 10-day LD50. In vitro assays for effects of PCBs on phagocytosis agreed with mammalian studies, demonstrating potent suppression of phagocytosis by the non-coplanar PCB congener 138 and no suppression by the coplanar congener 126. However, when the effects of the two PCB congeners were evaluated for suppression of resistance to

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Mohammadian, Gholamreza. "Immunotoxicity of Chromium Contaminated Soil in the Earthworm, Lumbricus Terrestris." Thesis, University of North Texas, 1993. https://digital.library.unt.edu/ark:/67531/metadc501250/.

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Objective was to assess the toxicity of chromium (Cr) contaminated soil (CS) using the earthworm Lumbricus terrestris. Specific aims were to determine: (1) survival (LC50); .(2) immunotoxicity as indicated by lysozyme activity, coelomocyte counts, secretory (SR) and erythrocyte rosette (ER) formation, and phagocytosis; and (3) compare effects of CS exposure with those of Cr spiked artificial soil (AS) . CS Cr concentration was 8.78 mg/g with 98.2% being Cr^3+ and 1.8% being Cr^6+. Using 14 d AS protocol the LC50 was 6.49% CS: AS mixture. CS concentrations of 0.5, 1.0, 2.5 and 5.0% were subleth

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11

Neethling, Michelle. "An in vitro study on the immunotoxicity of South African beer." Thesis, University of the Western Cape, 2008. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_5120_1257318050.

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<p>&quot<br>Traditionally brewed beers are of cultural and economic importance to many African nations. The presence of mycotoxins in African beer is a topic that needs to be addressed, since most African countries have a climate of high humidity and temperature that favours the growth of moulds. Mycotoxins challenge not only the health of animals and humans, but also the economy, especially in underdeveloped countries where contamination is most likely. Literature proves that mycotoxins depict various effects on the immune system including immunotoxicity. Beer analysis is therefore of utmost

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12

Steer, Sarah Jane. "Problems inherent in developing in vitro tests for phototoxicity and immunotoxicity." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357820.

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13

Kamath, Arati B. "Apoptosis as a Mechanism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-Induced Immunotoxicity." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/40094.

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly toxic environmental pollutant and is well known for its immunotoxic effects, particularly on the thymus. The exact mechanism by which TCDD induces thymic atrophy is not known. In the current study, we investigated whether TCDD triggers apoptosis in the thymocytes and whether Fas and Fas ligand play a role in TCDD-mediated immunotoxicity. Administration of a single dose of TCDD at 0.1, 1, 5 or 50 mg/kg body weight intraperitoneally into C57BL/6 +/+ mice caused a significant dose-dependent decrease in the thymic cellularity; whereas, in t

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14

Chen, Shing-Chong. "Enzyme Assays Using Earthworms for Assessing Innate and Nonspecific Immunotoxicity of Xenobiotics." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc277598/.

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Principal objectives of my research were to: (1) report for the first time that coelomocytes are able to reduce NBT dye and confirm the presence of lysozyme-like activity in earthworm; (2) develop a standard methodology for determination of NBT reduction and lysozyme-like activity in earthworms; (3) compare NBT reduction and lysozyme-like activity in earthworms with those of murine and human cells and fluids; and (4) demonstrate the sensitivity of earthworm NBT reduction and lysozyme-like activity as the assays using matrics in refuse-derived fuel fly ash (RDFF) and CuSO4.

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15

Giggleman, Marina A. "Phagocytosis by Earthworm Coelomocytes : A Biomarker for Immunotoxicity of Hazardous Waste Site Soils." Thesis, University of North Texas, 1997. https://digital.library.unt.edu/ark:/67531/metadc278359/.

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Several biomarkers (cell viability and phagocytosis) based on earthworm (Lumbricus terrestris) immune cells (coelomocytes), together with whole-worm mortality (LC/LD50's), were used to assess a bioremediation attempt to reduce pentachlorophenol (PCP) toxicity in a former wood processing hazardous waste site (HWS).

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16

Murray, Stephanie Mae. "Evaluation of Sequential Events in Phagocytosis by Earthworm Coelomocytes as Potential Immunotoxicity Biomarkers." Thesis, University of North Texas, 1998. https://digital.library.unt.edu/ark:/67531/metadc278424/.

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This research evaluated the potential of activation and attachment, as sequential companion biomarkers of phagocytosis by earthworm, Lumbricus terrestris, immunoactive coelomocytes for use in immunotoxicology. The potential was assessed by exposing earthworms to sublethal concentrations of CuSO4 and Arochlor 1254®, chemicals used as reference or standard immunotoxicants.

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17

Harford, Andrew James, and andrew harford@rmit edu au. "The characterisation of Australian freshwater fish immune systems and their response to immunomodulators." RMIT University. School of Medical Science, 2005. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20060307.171411.

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The Murray-Darling basin is the largest river system in Australia with significant economic, social, recreational and cultural value. It supplies water for drinking and agriculture to a large inland area of the eastern and southern states of Australia. It is also the ultimate sink for many environmental contaminants that result from human activities within the catchment. Aquatic organisms live intimately with their environment and may be continuously exposed to these contaminants through the water column or the food chain. Some chemicals are bioaccumulated and biomagnified in tissue

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18

Punareewattana, Korawuth. "Immune Function Determination in Mice Dermally Exposed to Permethrin." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/9868.

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Inhibited immune responses have been observed following occupational, inadvertent, or therapeutic exposure to chemically diverse xenobiotics. In the present studies, preliminary data were generated showing limited but significant systemic immunotoxicity following low-level topical exposure to the pyrethroid insecticide, permethrin (formerly not considered an immunotoxicant). Permethrin was applied to the shaved dorsal interscapular region of C57Bl/6N mice at doses of 0.5, 1.5, or 5.0 μl/day. The highest of these doses was approximately equal to 215 μg/kg/day, which is about seven times the est

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19

Handy, Andrea Renee. "Acute Toxicity and Immunotoxicity Testing of Total Petroleum Hydrocarbons in Aquatic and Terrestrial Organisms." Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1185910580.

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Reid, Lynnda Louise 1949. "Use of staphylococcal enterotoxin A-induced interleukin 2 production as an indicator of immunotoxicity." Thesis, The University of Arizona, 1990. http://hdl.handle.net/10150/278371.

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An in vitro assay measuring IL-2 production as an index of compromised immune function was developed using primary splenocytes from female C57BL/6 mice pretreated with olive oil, 30 mg/kg Cyclosporin A, or 220-880 mg/kg benzene. Splenocytes were mitogen-stimulated to produce IL-2 with SEA, Con A or PHA. Benzene induced inhibition of IL-2 production was demonstrated by incubating the splenocyte culture supernatant fraction with an IL-2 dependent T-lymphocytic cell line. Cell proliferation was measured by blastogenesis and MTT reduction as an index of IL-2 mediated response. Benzene and cyclospo

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21

Prater, Mary Renee. "Immunotoxicity of Dermal Permethrin and Cis-Urocanic Acid: Effects of Chemical Mixtures in Environmental Health." Diss., Virginia Tech, 2002. http://hdl.handle.net/10919/11047.

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The present study examined adverse effects of sunlight exposure (mimicked by intradermal cis-urocanic acid, cUCA) on local and systemic immune responses, with or without co-exposure to the immunotoxic insecticide permethrin. A single exposure to cUCA caused diminished splenic macrophage phagocytosis that was persistent up to 30 days post-exposure. Five-day exposure to cUCA subtly increased splenocyte proliferation in response to the T cell mitogen Concanavalin A. Four-week exposure to cUCA caused increased splenic lymphocyte cellularity, thymic hypocellularity, and enhanced hydrogen peroxide

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22

Pryputniewicz, Sarah Jean. "Mechanism of TCDD-Induced Immunotoxicity: The Role of Cell Activation in the Generation of Toxicity." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/9691.

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2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin is well known for its immunotoxic effects on the thymus, as well as on B and T lymphocyte functions. Previous studies suggested that TCDD exerted immunotoxic effects only on cells differentiating in response to antigenic challenge. To this date, no work has been done to characterize the long-term effects of TCDD on the activated cells. Additionally, no studies have been done to determine whether TCDD has any effect on resting T cells. In the current study, therefore, we investigated the effects of TCDD on activated and resting cells within the same animal

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23

Gonon, Alexis. "Impact d'une exposition aux nanoparticules sur les fonctions des cellules présentatrices d'antigènes." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV078/document.

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Les nanoparticules (NP) ont été introduites en médecine pour développer des médicaments intelligents ou des agents d'imagerie. En raison de leur petite taille (<200 nm), les NP permettent la mise en place de thérapies ciblées, augmentent la diffusion et l’efficacité des drogues, tout en facilitant les modes d’administration et en diminuant les couts de santé publique. Malgré les promesses que présentent les NP pour la médecine, les risques potentiels pour la santé humaine associés à une exposition aux NP restent mal documentés ; en particulier en ce qui concerne leurs effets sur le système

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24

Liamin, Marie. "Exposition in vitro de lymphocytes T humains aux hydrocarbures aromatiques polycycliques : étude des effets immunotoxiques." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B060/document.

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Les hydrocarbures aromatiques polycycliques (HAPs), tels que le benzo(a)pyrène (B[a]P), sont des contaminants environnementaux ubiquistes générés lors de la combustion de matière organique. Ces composés ont été associés au développement d'effets toxiques sur la santé humaine, notamment des effets cancérigènes et immunotoxiques, principalement liés à l'activation du récepteur aux hydrocarbures aromatiques (RAh). Parmi les cellules du système immunitaire, les lymphocytes T apparaissent comme des cibles majeures des HAPs. Des résultats antérieurs, obtenus au laboratoire, ont montré que l'activati

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25

Domingues, Alexandre. "Avaliação do potencial imunotóxico do herbicida diuron: estudo de toxicidades de 28 e 90 dias(doses repetidas) /." Botucatu : [s.n.], 2007. http://hdl.handle.net/11449/95906.

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Resumo: Escassas informações são encontradas na literatura a respeito do potencial imunotóxico do Diuron, um herbicida derivado da uréia, utilizado no Brasil e no mundo nas lavouras de café, cana-de-açúcar, algodão, abacaxi, citros, alfafa e trigo. Desta forma, o presente estudo teve por objetivo investigar a toxicidade do Diuron sobre o sistema imunológico. Para isso, foram avaliados parâmetros gerais de toxicidade, bioquímicos, hematológicos, histopatologia de órgãos linfohematopoiéticos e fenotipagem de linfócitos T CD4, T CD8 e B de ratos Wistar machos. Foram utilizados dois protocolos exp

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26

Bolt, Alicia Marie. "Arsenite Alters Lysosome-Mediated Degradation and the Autophagy Process Leading to Immunosuppression in Human B-Lymphoblastoid Cell Lines." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/222895.

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The immune system is a target of arsenic toxicity. Epidemiological data have shown that arsenic exposure is associated with characteristics of immunosuppression. Human B-lymphoblastoid cell lines (LCL) were used as an in vitro model of immune cell targeting by arsenic to investigate the mechanism of arsenic-induced cytotoxicity, which could provided insight into the mechanism underlying arsenic-induced immunotoxicity leading to the immunosuppression observed in humans. In LCL arsenite-induced cytotoxicity was not associated with apoptosis, but associated with hallmarks of autophagy, a cell st

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Holloway, Jennifer C. "Investigation of white blood cell phagocytosis as a potential bio-marker of mercury immunotoxicity in birds." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33002.

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White blood cell phagocytosis was investigated and used with avian blood, and assessed as a potential biomarker for mercury immunotoxicity in free ranging birds (common loons). Phagocytosis is an essential immunological function and can be measured using flow cytometry. The assay was assessed with in vitro exposure using whole blood and isolated white blood cells (WBC) from domestic chickens, and with in vivo exposure using whole blood from captive doves and wild loons. McHg at 0.1ppm significantly depressed phagocytic capacity of isolated WBCs without affecting their viability, but did not af

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28

Besteman, Elizabeth Gayle. "Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Diethylstilbestrol (DES) in the Fetal Mouse Thymus and Liver." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/27887.

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Diethylstilbestrol (DES) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been identified as immunotoxicants causing thymic atrophy, thymocyte hypocellularity, phenotypic changes detected by CD4 and CD8 surface antigens, and progenitor T-cell targeting in the fetal mouse. We hypothesized that gestational exposure to these two compounds may lead to comparable histologic and gene expression alterations in the fetal mouse thymus and liver. Treatment of pregnant C57Bl/6 mice with doses of 5 or 10 ug/kg TCDD or 48 ug/kg DES by oral gavage on gestation days (gd) 14 and 16 severely depressed day

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29

Vemireddi, Vimala. "Immunotoxic and Oxidative Effects of Endosulfan and Permethrin on Murine SPlenocytes, in vitro." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/32983.

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Indiscriminate use of pesticides appears to alter immune response in non-target organisms such as humans and other animals. Thus, immune modulation is considered as one of the potential risks and consequences following exposure to these chemicals. Because of the widespread usage, exposure to mixtures of pesticides during the lifetime of individuals is unavoidable and can result in potentiation of the toxic effects. Because immune cells are more susceptible to toxic insults at a lower dose than most other cell types, the effects of pesticides and their mixtures on murine splenocytes were evalua

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Fowler, Jodi. "The Assessment of Effects of Carbon Quantum Dots on Immune System Biomarkers Using RAW 264.7 Macrophage Cells." University of the Western Cape, 2020. http://hdl.handle.net/11394/7712.

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>Magister Scientiae - MSc<br>Nanotechnology is a rapidly growing field of research. Due to major innovations brought about by developments in nanotech, several consumer products are currently available containing nanomaterials. The increase of nanomaterial production and use is accompanied by the increased potential of human, plant and animal exposure to these nanomaterials. As a relatively new nanomaterial, carbon quantum dots (CQDs) are being extensively used and researched due to its unique properties. Although many studies have assessed the toxic potential of CQDs, and found them to exhibi

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Algadi, Hend Emhemed. "Effects of graphene oxide nanoparticles on the immune system biomarkers produced by RAW 264.7." University of the Western Cape, 2019. http://hdl.handle.net/11394/6983.

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Magister Scientiae (Medical Bioscience) - MSc(MBS)<br>Graphene oxide (GO) is a single carbon layer, oxygen bearing graphene derivative, containing hydroxyl and carboxyl groups. Graphene oxide nanoparticles (GONPs) are promising nanomaterials for a variety of applications such as electrochemical analysis, adsorption of biomolecules, biosensors and drug and vaccine delivery systems. While these newly engineered nanoparticles hold great potential for developments in industry and medicine, the widespread use of these material will inevitably result in GO residues in the environment where they coul

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Shoko, Yeukai Phoebe. "The screening of phyto-pesticides for potential adverse effects on human health." Thesis, University of the Western Cape, 2010. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_7861_1328620487.

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<p>Pesticides are designed to control or eliminate pests such as insects, rodents, weeds,<br /> bacteria, and fungi. They are used at a global scale for agricultural produce. Although<br /> pesticides play a significant role in increasing food production and eliminating diseases,<br /> exposure to pesticides may be harmful to non-target organisms. As a result concern over<br /> safety and resistance to pesticides has increased and there is pressure to reduce use and<br /> search for more environmentally and toxicologically safe and efficacious pesticides. Most<br /> pesticides currently in use

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Domingues, Alexandre [UNESP]. "Avaliação do potencial imunotóxico do herbicida diuron: estudo de toxicidades de 28 e 90 dias(doses repetidas)." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/95906.

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Made available in DSpace on 2014-06-11T19:27:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-02-26Bitstream added on 2014-06-13T20:17:33Z : No. of bitstreams: 1 domingues_a_me_botfm.pdf: 594143 bytes, checksum: 583e125c7a9e0c3c3a4f6516dabc6d61 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Escassas informações são encontradas na literatura a respeito do potencial imunotóxico do Diuron, um herbicida derivado da uréia, utilizado no Brasil e no mundo nas lavouras de café, cana-de-açúcar,

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Ponce, Fernando. "Estudo das alterações imunológicas e comportamentais provocadas pelo crack em ratos adultos expostos à droga por via pulmonar." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-15122015-143149/.

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O crack, uma droga de abuso constituída principalmente por cocaína, continua sendo um grande problema social e de saúde pública. Apesar de vários estudos em modelos animais com outras formas de cocaína, raros são os relatos sobre os efeitos da exposição pulmonar ao crack em roedores, devido à dificuldade de realizar a exposição dos mesmos à droga, o que seria de grande valia, uma vez que eliminaria variáveis encontradas em usuários, como o uso de outras drogas. Assim, o propósito do presente estudo foi avaliar os efeitos tóxicos, imunotóxicos e ainda, alterações comportamentais de ratos Wistar

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35

Rahman, Qazi Mousumi. "Immunohepatotoxicity of the persistent environmental pollutants perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS)." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-63180.

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Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS), manufactured for a variety of industrial and consumer applications, are ubiquitous environmental pollutants. Their accumulation in humans and wildlife raises serious health concerns. Here, we examined the potential effects of PFOA and PFOS on the innate immune system in mice. Short-term dietary exposure to high doses reduces the total number and subpopulations of circulating white blood cells. Moreover, production of proinflammatory cytokines by macrophages in the peritoneal cavity and bone marrow, but not in the spleen following

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Mendes, Patrícia Franciscone. "A cetamina associada ou não ao álcool, quais as consequências toxicológicas e sua influência no estresse oxidativo? Estudo em ratos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-12122018-113556/.

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O uso recreacional e os efeitos deletérios de drogas lícitas e/ou ilícitas é considerado um problema de saúde pública. Dentre estas drogas destaca-se a cetamina, um anestésico empregado na veterinária e o etanol, a droga lícita mais utilizada. Além dos efeitos centrais, estudos revelam que a cetamina e o etanol possuem propriedades imunomodulatórias. No entanto, poucos estudos são realizados com a associação destas drogas; assim, o objetivo deste estudo foi o de avaliar os efeitos tóxicos, imunotóxicos, o potencial oxidativo e os possíveis efeitos neurotóxicos resultantes do consumo associado

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Stetzer, Randy T. "Immunological and Developmental Effects of Polybrominated Diphenyl Ethers (PBDEs) and 2,3,7,8-tetrachloro-p-dioxin (TCDD) in Birds." Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1189789668.

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Rhile, Mark Joseph. "Immunotoxicity of TCDD : role of Fas expression and MHC phenotype on TCDD-mediated thymic artophy and decrease in peripheral T cell responsiveness /." Thesis, This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-01312009-063044/.

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Walderdorff, Louise. "Étude comparative de la réactivité des cellules du système immunitaire (invertébrés et vertébrés) vis-à-vis des pesticides." Electronic Thesis or Diss., Université de Lorraine, 2019. http://www.theses.fr/2019LORR0268.

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Les pesticides synthétiques sont de plus en plus utilisés dans la lutte antiparasitaire moderne et dans l'agriculture conventionnelle. Leurs résidus sont fréquemment trouvés dans notre environnement et dans notre alimentation. Le groupe des insecticides les plus couramment utilisés sont les néonicotinoïdes et leurs résidus ont par exemple été trouvés dans les fruits et légumes traités, le pollen et le miel, ainsi que dans l’organisme des abeilles. Même si les concentrations environnementales rencontrées sont plutôt faibles par rapport aux concentrations pour la toxicité aiguë, elles mènent à d

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Lautert, Claudia. "Efeitos de micotoxinas sobre o sistema imunológico de frangos de corte." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/116166.

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Aves domésticas são um dos principais alvos da contaminação alimentar com micotoxinas. O que contribui para o aumento dos prejuízos da indústria avícola devido a problemas como: alta mortalidade, redução do ganho de peso, alteração da conversão alimentar, imunossupressão, anormalidades embrionárias e morte embrionária precoce. Além disso, o acúmulo residual de micotoxinas na carne é uma preocupação da Saúde Pública. Diversos métodos são utilizados para a avaliação da citotoxicidade induzida por agentes tóxicos, incluindo a inibição do crescimento celular, a avaliação da capacidade celular de s

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Mendes, Patrícia Franciscone. "Avaliação dos possíveis efeitos tóxicos e imunotóxicos da Uncaria tomentosa em ratos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-13112014-162653/.

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A Uncaria tomentosa (U. tomentosa), popularmente conhecida como \"Unha-de-gato\", é uma planta medicinal nativa das Américas, mundialmente empregada devido às suas atividades anti-inflamatórias e imunomodulatórias. O consumo desta planta ocorre não apenas na forma in natura, mas principalmente como fitoterápico, sendo muitas vezes utilizada de forma indiscriminada pela população. Apesar de vários estudos revelarem as propriedades terapêuticas da U. tomentosa, poucos são os trabalhos que empregam protocolos estabelecidos por agências regulamentadoras internacionais, para a avaliação dos possíve

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Deak, Kristina L. "Cloning and Characterization of IL-1β, IL-8, IL-10, and TNFα from Golden Tilefish (Lopholatilus chamaeleonticeps) and Red Snapper (Lutjanus campechanus)". Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5416.

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Cytokines are pleiotropic and redundant signaling molecules that govern the inflammatory response and immunity, a critical ecological parameter for organism success and population growth. Produced at the site of injury or pathogen intrusion by a variety of cell types, cytokines mediate cell-signaling in either an autocrine or paracrine manner. The type and magnitude of the cytokine milieu produced subsequently dictates the strength and form of immune response. As the most diverse vertebrate group, with a high sensitivity to contaminants, fish represent an important foci for the evaluation of i

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Dao, Duy Khiem. "Immunotoxicité des dioxines." Paris 5, 1997. http://www.theses.fr/1997PA05P127.

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Smith, Dorinda Ann. "The Development and Application of a Hemolytic Plaque Forming Cell Assay (PFC) and a Cytotoxic T-Lymphocyte Assay (CTL) in Tilapia (Oreochromis niloticus) for Immunotoxicity Risk Assessment of Environmental Contaminants." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/36948.

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The prospect of utilizing the cichlid teleost tilapia (Oreochromis niloticus) as an alternative experimental model to mammals for immunotoxicity risk assessment is currently being proposed. As such, the National Toxicology Program's (NTP) standard battery of rodent immunotoxicity assays is being developed for use in this fish species. Included in the testing series are the hemolytic plaque forming cell (PFC) and the cytotoxic T-lymphocyte (CTL) assays, quantitative indicators of antibody production and cell-mediated activity, respectively. The assays were modified in consideration of specif

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Costa, Leonor Coutinho. "Mechanisms of immunotoxic effects of nanomaterial in fish." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12616.

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Mestrado em Química - Química Analítica e Qualidade<br>Information and knowledge related to nanotechnology raise new challenges to the scientific community mainly in terms of human health risks and environmental implications associated to nanomaterials. In this perspective, the contamination of aquatic environments cannot be overlooked since it is an ultimate repository of the contaminants where this emerging appears as part of a cocktail of different classes of contaminants. Thus, the major task of this work was to connect gaps in current knowledge with a comprehensive sequence of biological

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Hernandez, Denise Marie. "Immunotoxicological Evaluation Of Critical Windows Of Development Following Exposure to 1,2:5,6 Dibenzanthracene in B6C3F1 Mice." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1605.

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Vi-Fane, Sylvie. "Immunotoxicité du mercure et de ses dérivés." Paris 5, 1993. http://www.theses.fr/1993PA05P135.

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Blot, Christian. "Immunotoxicité des molécules médicamenteuses : mécanismes impliqués dans les différences inter-espèces." Paris 11, 1994. http://www.theses.fr/1994PA114844.

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Bruneau, Audrey. "Immunotoxicité des nanoparticules de Cd/S, Cd/Te et d’Ag sur des espèces modèles." Brest, 2011. http://www.theses.fr/2011BRES2015.

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A l'heure actuelle, l'usage des nanoparticules (NP5) est de plus en plus médiatisé. Elles sont maintenant utilisées à grande échelle dans de nombreux domaines, L’objectif principal de cette thèse était donc d’évaluer l’immunotoxicité des NPs de Cd/S, Cd/Te et d’Ag sur 4 espèces modèles: l’humain, la souris, la truite arc en ciel et la moule bleue, Dans le cadre de ces travaux, nous avons défini quatre sou objectifs: 1) déterminer l’impact des NPs sur différentes cellules et systèmes immunitaires 2) évaluer les facteurs influençant la toxicité des NPs; 3) identifier les atteintes mécanistiques

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Deyo, James A. "Immunotoxicity of the pyrrolizidine alkaloid monocrotaline in C57B1/6 mice." Thesis, 1991. http://hdl.handle.net/1957/36782.

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Monocrotaline (MCT) is a member of a class of naturally occurring phytotoxins known as pyrrolizidine alkaloids (PAs). Exposure to PAs can result in liver and cardiopulmonary lesions as well as lymphoid organ atrophy. In the present study C57BI/6 (B6) mice received MCT (0-150 mg/kg/day, po) for 14 days. Overt toxicity was minimal and observed only at highly immunosuppressive doses. Following MCT exposure, significant dose-dependent suppressions were observed in the following immune responses: numbers of antibody producing cells, cytotoxic T- lymphocyte activity, and NK cell cytotoxicity. The an

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