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Rozprawy doktorskie na temat „In-situ hybridisation”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Princivalle, Alessandra Patrizia. "Studies of GABAb receptors in epilepsy." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289300.

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The binding of a novel GABAs receptor radioligand eH]-CGP62349 to human hippocampal control and epileptic sections was investigated using quantitative receptor autoradiography. Kinetic analyses performed on rat brain sections, to conserve the use of human tissues, demonstrate that eH]-CGP62349 associated rapidly. The same radioligand dissociated rapidly initially, then very slowly. Utilising human hippocampus it was shown that CH]-CGP62349 bound with high affinity (O.SnM) to human control hippocampal sections. The kinetics of GABAs receptor in human hippocampus using the novel compound confirm

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2

Hoyle, Jane Anthea. "In situ hybridisation for the detection of viral nucleic acids." Thesis, University of St Andrews, 1991. http://hdl.handle.net/10023/13924.

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The technique of in situ hybridisation was optimised for the detection of viral RNA using radioactively-labelled single-stranded DNA and RNA probes, and applied to three areas of interest. Optimum hybridisation conditions were determined in vitro using cells infected with the single-stranded negative sense RNA paramyxoviruses. Transcription of RNA probes was the most rapid and efficient method of probe labelling, since electrophoretic purification was not required and large amounts of RNA were produced. However, their use for in situ hybridisation was problematic due to RNase contamination and

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3

Hauxwell, Angela Jane. "In situ hybridisation for studying embryo development in Pisum sativum L." Thesis, University of East Anglia, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279676.

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HajMohammadi, Sassan. "Development of FISH technology in pathological tissue." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284578.

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5

Wu, Yih-Yiing. "Response of skin to noxious stimuli : studies using in situ hybridisation." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263124.

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6

Birchall, Philip Simon. "Multicolour fluorescence in situ hybridisation to RNA in whole-mount Caenorhabditis elegans." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296668.

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7

Zheng, Yun-Ling. "Rapid prenatal diagnosis of common fetal aneuploidies by fluorescence in situ hybridisation." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318418.

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8

Teo, Chong Gee. "Analysis of the Epstein-Barr virus-host relationship by in situ hybridisation." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47684.

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9

Mohaddes, Ardebili Seyed Mojtaba. "Optimisation of interphase fluorescence in situ hybridisation for detection of common aneuploidies." Thesis, Connect to e-thesis, 1996. http://theses.gla.ac.uk/692/.

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Thesis (Ph.D.) - University of Glasgow, 1996.<br>Ph.D. thesis submitted to the Faculty of Medicine, Department of Division of Developmental Medicine, University of Glasgow, 1996. Includes bibliographical references: p. 118-132. Print version also available.

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10

Hammond, David William. "Analysis of non-Hodgkin's lymphoma by conventional cytogenetics and fluorescence in-situ hybridisation." Thesis, University of Sheffield, 1995. http://etheses.whiterose.ac.uk/3064/.

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Cytogenetic analysis was performed on 40 non-Hodgkin's lymphoma (NHQ node biopsies. Chromosomes X, 3 and 12 were the most frequently gained; of the much rarer monosomies, loss of chromosome 13 was most common. Structural abnormalities primarily involved chromosomes 14,1,18,6 and 17. A markedly greater number of chromosome gains were associated with low-grade disease when compared to high-grade. In order to obtain further information from the cytogenetic analysis of the NHL karyotypes, the fluorescence in-situ hybridisation (FISH) technique was applied to the series. The activation state of add

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11

Jaffe, Benjamin. "Genome analysis of Hordeum bulbosum L. and hybrids with H. vulgare L." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302327.

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12

Taylor, Clare Petronella Florence. "The use of fluorescence in situ hybridisation techniques in the diagnosis and prognosis of malignancy." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297282.

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13

Buckle, V. J. "The application of in situ hybridisation to the genetic analysis of the X chromosome." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370315.

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14

Sinclair, Paul Burdwood. "A fluorescence in-situ hybridisation and molecular investigation of leukaemia associated abnormalities of chromosome 6q." Thesis, University College London (University of London), 2002. http://discovery.ucl.ac.uk/1382604/.

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Deletions of the long arm of chromosome 6 are a recognised recurrent cytogenetic abnormality associated with ALL. Balanced rearrangements of 6q are less common but occur in leukaemias of both lymphoid and myeloid origin. With the aim of identifying genes that contribute to leukaemia through loss or rearrangement the breakpoints of translocations and deletions of 6q were mapped by FISH. Comparison between the mapped deletions led to the identification of a 4.8 Mb CDR and candidate tumour suppressor gene (GluR-6). Expression of GluR-6 was demonstrated to occur in haernatologic tissues and mutati

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15

Williams, Lisa. "Fluorescence in situ hybridisation (FISH) analysis of chromosomal aberrations in gastric tissue : the involvement of Helicobacter pylori." Thesis, Swansea University, 2004. https://cronfa.swan.ac.uk/Record/cronfa43067.

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Gastric cancer is a common cause of cancer death in the UK. It most often presents in patients when the disease is advanced, and hence treatment options are limited. As such, studies on the pre-malignant stages of gastric cancer, and interest in the mechanisms of the carcinogenic process (reactive oxygen species, ROS) and the agents that may drive the carcinogenic pathway {Helicobacter pylori infection), are important, with a view to improving disease outcome. This series of experiments has firstly shown, using CBMN assay +/- kinetochore staining and interphase FISH, that ROS causes aneuploidy

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16

Shone, John William. "Development and implementation of fluorescent in situ hybridisation for the detection of human cutaneous bacterial microflora." Thesis, Institute of Cancer Research (University Of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511179.

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Turner, Gabrielle M. "Development of in situ hybridisation to examine tissue-specific expression patterns of the invertase genes in sugarcane culm." Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/16621.

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Thesis (MSc)--University of Stellenbosch, 2005.<br>ENGLISH ABSTRACT: The goals of this project were firstly to develop the tissue preparation and in situ hybridisation protocols for sugarcane culm tissue, and secondly to use the developed techniques to examine the expression patterns of three invertase isoforms in sugarcane internodes of various developmental stages. Sugarcane invertases have been the focus of intense research for many years, yet almost nothing is known of their tissue-specific distribution. It was thought that by characterising their expression patterns using in situ hy

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18

Wall, Wilson. "A study of variation in human chromosomes shown by photometry, G, C, replication banding and in situ hybridisation." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314792.

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Stindl, Martin Maria Matthias. "Evaluation of ligation methods and the synthesis of a specific PNA-encoded peptide library." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/17927.

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Dysfunctional or over and under expressed enzymes play a crucial role in a variety of diseases. A tool that can identify dis-regulated enzymes in individual patients would be beneficial and would allow personalised treatment. For this purpose, a 10,000 membered ‘spit-and-mix’ PNA-encoded peptide library with a cell penetrating peptide was synthesised and interrogated with K562 cell lysate and intact K562 cells. This allowed the specific enzyme activity pattern for ABL tyrosine kinase from both inside a cell and a lysate to be obtained. Hybridisation of this library with a DNA-microarray result

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20

Virgo, Lisa. "A study of neurotransmitter function in motor neurone disease : using the techniques of in situ hybridisation and receptor autoradiography." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336581.

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21

Achuthan, Rajgopal. "An evaluation of the chromosome 1p region and the BCL10 gene in malignant lymphoma, by fluorescent in-situ hybridisation." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414499.

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22

Ramoutar, Rakeshnie. "The development of an in situ hybridisation technique to determine the gene expression patterns of UDP-Glucose dehydrogenase, pyrophosphate-dependent phosphofructokinase and UDP-Glucose pyrophosphorylase in sugarcane internodal tissues." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/49795.

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Thesis (MSc)--University of Stellenbosch, 2003.<br>ENGLISH ABSTRACT: The cellular expression of the enzymes implicated in regulating sucrose metabolism and accumulation in sugarcane is poorly understood. The present study was therefore aimed at the development of an in situ hybridisation (ISH) technique to study differential gene expression among the various cell types of the sugarcane culm. This technique in conjunction with northern and western blotting was then used to determine the sites of cellular and tissue specific expression of the cytosolic enzymes, UDP-Glc dehydrogenase, pyrop

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23

Pedras, Maria Inês Machado. "Investigation of the regulation mechanisms for bioplastics production from industrial residues." Master's thesis, Faculdade de Ciências e Tecnologia, 2013. http://hdl.handle.net/10362/10863.

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Dissertação para obtenção do Grau de Mestre em Biotecnologia<br>The current high demand for plastics has become unsustainable. Polyhydroxyalkanoates are biopolymers stored by bacteria that can potentially replace modern plastics due to: wide range of applications; biodegradability; use of renewable resources as feedstock. High costs of current Polyhydroxyalkanoates production can be reduced using mixed cultures of organisms. Activated sludge from wastewater treatment plants is selected for Polyhydroxyalkanoates production through the imposition of cycles of intermittent feeding. In this stud

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24

com, dbearham@hotmail, and Douglas Bearham. "Identification and characterisation of two haplosporidian parasites of oysters in north Western Australia." Murdoch University, 2008. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20081114.120135.

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A cryptic haplosporidian parasite was detected infecting rock oysters from the Montebello Islands in north-western Australia using a PCR targeting the parasites small ribosomal subunit gene. The PCR products were cloned and sequenced along with the remaining sections of the parasites SSU rRNA gene. Phylogenetic analysis of the sequence generated indicated a Minchinia species (Haplosporidia). The SSU sequence generated was used to develop two in situ hybridisation assays to visualise the parasite in H/E sections as well as a PCR assay to detect the parasite. The molecular assays were asses

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25

Bardin, Philip Greyling. "Human rhinovirus : development of an experimental disease program and detection in tissue employing in situ hybridisation and a polymerase chain reaction." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296349.

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26

Tholouli, Eleni. "The development of a novel quantum dot labelled oligonucleotide in situ hybridisation technique for analysis of gene expression in acute myeloid leukaemia." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527409.

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27

Wilkins, Bridget Sally. "Cell-stroma interactions in haemopoiesis studied by immunocytochemistry and in situ hybridisation in long-term cultures and trephine biopsies of human bone marrow." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242221.

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28

Leversha, Margaret Anne. "Cytological estimations of molecular genetic difference : applications and implications of fluorescence in situ hybridisation mapping in the long arm of human chromosome 9." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337902.

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29

Vontell, Regina Theresa. "Expression of toll-like receptor 3 in the preterm brain after white matter injury : a post-mortem study applying immunohistochemistry and in situ hybridisation." Thesis, King's College London (University of London), 2015. https://kclpure.kcl.ac.uk/portal/en/theses/expression-of-tolllike-receptor-3-in-the-preterm-brain-after-white-matter-injury(0eaf3659-2e87-46cb-bc4d-edff67b81e4d).html.

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Toll-like receptor-3 (TLR3) has been identified in a variety of intracellular structures of cells and has been shown to detect viral molecular patterns and damage-associated molecular patterns (DAMPs). This study investigates the cellular and subcellular localization of TLR3 and its downstream signaling pathway in post-mortem brain sections from preterm infants (26-32 weeks; gestational age) with and without white matter injury (WMI) pathologies. These results were compared with a sheep model of fetal inflammation by the administration of intravenous bolus infusion of either Escherichia coli l

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30

Somasekar, Amudha. "Fluorescence in situ hybridisation (FISH) analysis of chromosome 1 and gene expression levels of MAD2 and BUB1 levels in premalignant stages of gastric tissue." Thesis, Swansea University, 2011. https://cronfa.swan.ac.uk/Record/cronfa43141.

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Gastric cancer is a common cause of cancer death in the world. The mortality rate from gastric cancer is high in UK as it often presents late, often with local or distant metastasis. This makes the treatment options limited. The pathogenesis of gastric cancer occurs in a multi step pathway with pre cancerous conditions leading to cancer eventually. It is important to understand this carcinogenic process (aneuploidy and abnormal gene expression levels) and the driving forces (eg. Helicobacter pylori infection) which will enable us to alter the disease outcome. This series of experiments include

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Louw, Amber. "The added value of BAP1 immunohistochemistry and fluorescence in situ hybridisation for CDKN2A/p16 and NF2 in the diagnosis and prognostication of pleural mesothelioma." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2023. https://ro.ecu.edu.au/theses/2661.

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Background: Mesothelioma is a rare but aggressive malignancy with therapeutic options that are generally palliative. The malignancy can be challenging to diagnose, commonly due to scant samples, often requiring patients to undergo multiple procedures before a definitive diagnosis can be reached. In more recent years ancillary tests based on the common molecular alterations in the disease have become more widely available to pathologists. However, the role of these investigations in the diagnostic process, identification of early disease and the implications for therapeutic options are not well

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Päällysaho, S. (Seliina). "Contribution of X chromosomal and autosomal genes to species differences in male courtship songs of the Drosophila virilis group species." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514265831.

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Abstract In sympatric Drosophila species, songs produced by male wing vibration during courtship are an effective mechanism preventing interspecific matings and maintaining sexual isolation between different species. These songs can vary greatly even between closely related species. The aim of this study was to localise X chromosomal and autosomal genes affecting species differences in male courtship song and to study their interaction in the D. virilis group species. Various genes were probed by in situ hybridisation on the X chromosomes of six species of the group, which enabled us

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Caburet, Sandrine. "Structure mosai͏̈que et instabilité de l'ADN ribosomal humain : implications dans la sénescence et la cancérogenèse." Paris 7, 2002. http://www.theses.fr/2002PA077038.

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Mohd, Sairi Mohd Fareed. "Isolation of cells from a Marine Source Responsible for Hemocyanin Biosynthesis." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13617.

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Molluscan rhogocyte cells are known to synthesise the largest respiratory proteins in nature known as hemocyanin. However, attempt to investigate the cells in vitro to understand the hemocyanin biosynthesis is difficult due to the lack of current knowledge on establishing a stable cell culture. Therefore, the aims of this study were to isolate rhogocyte cells from Haliotis laevigata and assessed their characteristics, distribution, capability to grow and synthesise hemocyanin in vitro. Using flow cytometry analysis and simultaneous staining of immunofluorescence and in situ hybridisation strat

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Varela, Filipa Alexandra Pereira Rosa. "Tipificação de Mycoplasma mycoides subsp. mycoides SC e detecção da sua aderência a células epiteliais pulmonares." Master's thesis, Faculdade de Ciências e Tecnologia, 2010. http://hdl.handle.net/10362/5092.

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Dissertação apresentada para a obtenção do Grau de Mestre em Genética Molecular e Biomedicina, pela Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia<br>A Peripneumonia Contagiosa Bovina (PPCB) é uma doença respiratória infecciosa, de grande relevo no âmbito da produção de gado bovino, causada pela bactéria Mycoplasma mycoides subsp. mycoides SC (MmmSC). Actualmente, a PPCB permanece endémica apenas em África, sendo aí responsável por perdas incontornáveis no sector pecuário. O último surto de PPCB detectado na Europa ocorreu em Portugal em 1999 mas, devido à sua natureza insidio

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36

Karlsson, Christina. "Biomarkers in non-small cell lung carcinoma : methodological aspects and influence of gender, histology and smoking habits on estrogen receptor and epidermal growth factor family receptor signalling." Doctoral thesis, Örebro universitet, Hälsoakademin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-19725.

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Non-small cell lung carcinoma is a leading cause of cancer mortality worldwide. There are gender and smoking associated differences both in tumour types and clinical outcome. Squamous cell carcinomas (SCC) are more frequent among smoking men while females develop adenocarcinomas (ADCA). NSCLC among never smokers are mainly ADCA, and occurs mostly in females. The present thesis elucidates the role of estrogen receptor (ER) and epidermal growth factor receptor family (EGFR/HER2-4) in NSCLC in the perspective of gender and histology as well as the influence of smoking on those biomarkers. A recen

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Krämer, Dorothee Charlotte Agathe. "Investigation of Mammalian Chromatin Folding at Different Genomic Length Scales using High Resolution Imaging." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19929.

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Chromatin ist ein Makromolekül, dessen Genregulation innerhalb des räumlich eingeschränkten Zellkerns organisiert werden muss. Die Genomorganisation ist eng mit Genaktivierung und Genrepression verknüpft. In den vergangenen Jahren wurde gezeigt, dass die DNA hierarchisch organisiert ist. Die Faltung läuft in aufeinander folgenden Schritten ab, wobei jede Organisationsebene sowohl zur räumlichen Komprimierung, als auch zur Genregulation beiträgt. In dieser Dissertation wurden mit Hilfe von hochauflösender Mikroskopie verschiedene Ebenen der 3D Chromatinorganisation auf Einzelzell-Basis untersuc

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Andersson, Ann-Catrin. "Studies on Human Endogenous Retroviruses (HERVs) with Special Focus on ERV3." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5342-2/.

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Betts, Jill Frances. "D-amino acid oxidase, D-serine and the dopamine system : their interactions and implications for schizophrenia." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:de02286f-3e33-4e3e-bc5b-222b62a28ba5.

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D-amino acid oxidase (DAO) is a flavin-dependent enzyme that is expressed in the mammalian brain. It is the metabolising enzyme of several D-amino acids, including D serine, which is an endogenous agonist at the glycine co-agonist site of the glutamatergic NMDA receptor. As such, regulation of D serine levels in the brain by DAO may indirectly modulate the activity of NMDA receptors. The expression and activity of DAO have been reported to be increased in schizophrenia. It has been identified as a putative susceptibility gene for the disorder, and as a potential therapeutic target. This thesis

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Petry, Frauke. "Charakterisierung eines neuen ATP-binding-cassette-Transporters aus der ABCA-Subfamilie." Doctoral thesis, [S.l.] : [s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2004/petry/petry.pdf.

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Davey, John William. "Identification of b-catenin and other RNAs in developing thalamic axons." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4011.

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This thesis provides evidence for the presence of multiple RNAs in the axons and growth cones of developing thalamic cells, particularly the mRNA for the cell adhesion and Wnt-signalling-related molecule b-catenin. After many decades of effort, mRNAs have been shown to be present in the axons of many different systems in recent years. Furthermore, these mRNAs have been shown to be locally translated at the growth cone, and this local translation is required for axons to turn in response to multiple guidance cues. As studies accumulate, it is becoming clear that different axonal systems contain

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Xu, Meng. "Specialised transcription factories." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:a41d3243-c233-491a-916b-4e329cace434.

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The intimate relationship between the higher-order chromatin organisation and the regulation of gene expression is increasingly attracting attention in the scientific community. Thanks to high-resolution microscopy, genome-wide molecular biology tools (3C, ChIP-on-chip), and bioinformatics, detailed structures of chromatin loops, territories, and nuclear domains are gradually emerging. However, to fully reveal a comprehensive map of nuclear organisation, some fundamental questions remain to be answered in order to fit all the pieces of the jigsaw together. The underlying mechanisms, precisely

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Bui, Loan Thuy. "Localisation of kallikreins in the prostate and association with prostate cancer progression." Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16276/1/Loan_Bui_Thesis.pdf.

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At present, prostate cancer is a significant public health issue throughout the world and is the second leading cause of cancer deaths in older men. The prostate specific antigen or PSA (which is encoded by the kallikrein 3/KLK3 gene) test is the current most valuable tool for the diagnosis and management of prostate cancer. However, it is insufficiently sensitive and specific for early diagnosis, for staging of prostate cancer or for discriminating between benign prostatic hyperplasia (BPH) and prostate cancer. Recent research has revealed another potential tumour marker, glandular kallikr

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Bui, Loan Thuy. "Localisation of kallikreins in the prostate and association with prostate cancer progression." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16276/.

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At present, prostate cancer is a significant public health issue throughout the world and is the second leading cause of cancer deaths in older men. The prostate specific antigen or PSA (which is encoded by the kallikrein 3/KLK3 gene) test is the current most valuable tool for the diagnosis and management of prostate cancer. However, it is insufficiently sensitive and specific for early diagnosis, for staging of prostate cancer or for discriminating between benign prostatic hyperplasia (BPH) and prostate cancer. Recent research has revealed another potential tumour marker, glandular kallikr

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Henwood, Anthony F. "The demonstration of estrogen receptors in various tumours a study using immunohistochemistry and in situ hybridisation /." 2004. http://hdl.handle.net/2440/37705.

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In order to study the incidence of Estrogen Receptors (ER) in breast carcinoma, lung carcinoma and melanoma, an in situ hybridisation technique for ER mRNA (ER mRNA-ISH) was developed. Various technical aspects of the procedure including tissue fixation, hybridisation conditions, and demonstration technique were investigated in order to obtain an optimum technique for routine use. ISH results were compared with ER immunohistochemistry using the monoclonal antibodies ER1D5 and D5. Commercially available biotin labelled antisense oligonucleotides to ER, Poly A (total mRNA), and sense chromograni

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Friedman, Brett. "Characterisation of a chromosomal translocation in an ovarian carcinoma cell line using fluorescence 'in situ' hybridisation." Thesis, 1996. http://hdl.handle.net/10539/22288.

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A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg in fulfilment of the requirements for the degree of Master of Science (Haematology)<br>The region Ilpl3-pl5 on the short arm of chromosome 11 (lip) has been implicated in the initiation or progression of several human malignancies including the embryonic rhabdomyosarcoma Wilms' tumour, bladder, renal cell and ovarian carcinoma. In this study, Fluorescence In Situ hybridisation (FISH) was used to identify the nature of a chromosome llp+ abnormality present in two ovarian carcinoma cell line

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Swaneburg, Uwe [Verfasser]. "Detektion von Porphyromonas gingivalis mittels Fluoreszenz-in-Situ-Hybridisation (FISH-Technik) / vorgelegt von Swaneburg, Uwe, geb. Patzer." 2006. http://d-nb.info/992236258/34.

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Peterková, Kristýna. "Lokalizace a kvantifikace mRNA kódující trávící peptidázy motolice Fascioloides magna." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-397285.

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Trematode peptidases are important molecules responsible for biocatalysis in many basal biological processes and are crucial in host-parasite interactions. Therefore, these enzymes are intensively studied in order to characterize their biological functions and to use them as potential diagnostic or therapeutic targets. Lately, investigation of transcriptome and secretome revealed, that adult Fascioloides magna (giant liver fluke) expresses and secretes a variety of peptidases. Thus, this thesis focuses on three newly identified enzymes: cathepsin L (FmCL), cathepsin B (FmCB) and cathepsin D (F

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Wedi, Edris. "Untersuchung des CFL-Phänotyps ("congenital fused labia" ) in dem Neuweltaffen Common Marmoset (Callithrix jacchus) unter demographischen, physiologischen und zytogenetischen Gesichtspunkten." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-AFBB-D.

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Gibson, Catherine Elizabeth. "The expression of hydrolytic enzymes in germinating barley grain." Thesis, 2017. http://hdl.handle.net/2440/114266.

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Modification of the barley grain endosperm in germination is fundamental to successful plant growth but also has important ramifications for down-stream industrial uses of barley, particularly in the malting and brewing industries. There are a battery of enzymes that are involved in the modification process but the sites of synthesis and action of only of a few of these have been described in detail and most have only been studied in isolated tissues. The development of a sensitive and robust in situ mRNA hybridization (ISH) procedure, which allows the detection of specific transcripts repres

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