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Rozprawy doktorskie na temat „In vitro oral tribology”

Autor: Grafiati

Data publikacji: 21 grudnia 2024

Data aktualizacji: 31 lipca 2025

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1

Ammam, Ianis. "Études et caractérisations tribologiques des mécanismes biophysiques de la lubrification orale." Electronic Thesis or Diss., Ecully, Ecole centrale de Lyon, 2024. http://www.theses.fr/2024ECDL0042.

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L’étude de la lubrification orale devient une problématique actuelle pour l’industrie agroalimentaire. Les analyses quantitatives permettent de comprendre et d’anticiper des mécanismes physiologiques, tels que la prédiction des phénomènes d’astringence des produits alimentaires. L’astringence se manifeste par une diminution de la lubrification de la muqueuse orale après la consommation de produits d’origine végétale. Cependant, les recherches actuelles sur la lubrification orale s’appuient sur des matériaux synthétiques qui représentent mal les tissus buccaux. Elles négligent les interactions

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Morell, Esteve Pere. "Diseño de alimentos lácteos con capacidad saciante. Relación entre estructura, procesamiento oral y percepción." Doctoral thesis, Universitat Politècnica de València, 2017. http://hdl.handle.net/10251/89093.

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This thesis studies how to increase the expected satiating ability in dairy products analyzing the effect of the incorporation of certain ingredients. The study of food reformulation with high expected satiating ability contributes to moderate size meal choice and to regulate food intake. In this thesis, two factors influencing the satiating ability perception of semi-solid foods have been mainly studied: a) the increase in oral processing time that produces prolonged orosensory signals, and b) the increase in protein content. The increase in oral processing time is produced by, for example,

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Madden, Stephen. "In vitro metabolism of novel progestogens." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314510.

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Healy, Claire Marie. "Recurrent oral ulceration : in vivo and in vitro studies." Thesis, Queen Mary, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250670.

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5

Anil, Sukumaran. "In vitro studies on candida, antimycotics and oral defences." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B2663448X.

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Elliott, D. R. "Canine oral biofilms : cultural, molecular, and in vitro studies." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444703/.

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The canine oral microbiota is poorly understood compared to that of humans. The aim of this work was to improve understanding of the canine oral microbiota. This was achieved by surveying the canine oral microbiota, determining coaggregation interactions between its members, and developing a laboratory microcosm. Bacteria were isolated from the dental plaque and saliva of dogs, and isolates were identified by comparative 16S rRNA gene sequencing. From 339 isolates, 84 phylotypes belonging to 37 genera were identified. Approximately half were identified to species level, and 28 % of these were

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7

Nair, Gopinathan Raj. "In vitro interactions of Candida species and oral bacteria." Thesis, Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19672548.

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8

Barlow, Yvonne Margaret. "Plasminogen activators in oral epithelium in vivo and in vitro." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/23702.

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9

Mills, Thomas Benjamin. "Development of in-vitro mouth methods for studying oral phenomena." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3474/.

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Manufacturers are under pressure to reformulate products to make healthier foods, without changing desirability or flavour. A better understanding of product breakdown under oral conditions is essential to structure novel products which are healthier without consumers noticing. In-vitro methods were developed to explore product behaviour when subject to a range of phenomena relevant to those in the mouth, with particular emphasis on lubrication behaviour. Polysaccharides common in food products were mainly used as model systems and salt release was studied in some systems. Three in-vitro syste

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10

Dalwai, F. "In vitro modelling of bacterial population shifts in oral biofilms." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444149/.

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In vitro models of dental plaque are a valuable tool for understanding the development of plaque-related diseases and assessing potential treatments for these diseases. The main focus of this study was the development of an in vitro model to characterise the changes in bacterial populations from dental plaque associated with health to one associated with gingivitis. By emulating environmental conditions in the oral cavity associated with gingivitis it was possible to see changes in the oral microbiota associated with gingivitis. Using traditional culture techniques the ascendancy of Actinomyce

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11

Aldsworth, Timothy Grant. "Microbial in vitro model of root surface caries." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360285.

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Rybalka, Alexandra. "In-vitro models for the culture of previously uncultured oral bacteria." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/lnvitro-models-for-the-culture-of-previously-uncultured-oral-bacteria(38cda49a-3110-4eaa-be0e-824a954743ba).html.

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Around half of oral bacteria have yet to be cultured, and their role in disease is therefore unknown. It is hypothesised that bacteria in biofilms have become dependent on growing in multi-species communities. TM7 phylum has no cultured representatives and some oral TM7 phylotypes have been associated with oral diseases such as periodontitis. The aims of this study were therefore to evaluate the ability of two model culture systems: Cooked Meat Medium and the Calgary Biofilm Device (CBD), to support the growth of mixed oral bacterial communities including uncultured bacteria, and to attempt to

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13

Romi, Fadi, and André Holmkvist. "Effect of Stevia on oral biofilms - a pilot study in vitro." Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19811.

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SyfteSyftet med denna laborativa pilotstudie in vitro var att undersöka hur den mikrobiella sammansättningen och pH i den orala biofilmen påverkades vid upprepad exponering för Stevia (steviosid och rebaudiosid A), sackaros eller en kombination av reb A och sackaros. Ett ytterligare syfte var att studera om isolat av orala bakterier kunde metabolisera reb A i buljongkultur. Material och metodBiofilmer från tre personer blev exponerade för 0,025 % steviosid, 0,025 % reb A eller 10 % Todd Hewitt (TH) under 15 minuter tre gånger dagligen i fyra dagar. Artbestämning gjordes i början och slutet av

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Biggs, Jonathan R. "Investigating the modulation of oral drug absorption using in vitro models." Thesis, Aston University, 2003. http://publications.aston.ac.uk/11003/.

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Dipeptides can be absorbed into cells via the dipeptide transporter (which also transported tripeptides and dipeptide derivatives). The optimum conditions for measuring the inhibition of Gly-Pro uptake in Caco-2 cells were identified. A number of structure-activity relationships were identified. These included the effects of increasing the amino-acid chain-length, and the presence of a thiol or hydroxyl group in the side-chain increased IC50 while the presence of a hydroxyl group did not. The benzyl esters had lower or equal IC50 values compared to the parent dipeptides while the methyl esters

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15

Hoque, Apu E. (Ehsanul). "Migration and invasion pattern analysis of oral cancer cells in vitro." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526220239.

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Abstract Desmoglein 3 (Dsg3) is an adhesion receptor in desmosomes, but relatively little is known about its role in cancer. In this study, the function of Dsg3 was investigated in oral squamous cell carcinoma (SCC) cell lines in vitro using locally established human leiomyoma tumor microenvironment (TME) matrices. Since Dsg3 has been identified as a key regulator in cell adhesion, we hypothesized that it may play a role in oral SCC cells adhesion and motility. Thus, one aim of the study was to explore this hypothesis by both gain and loss of function methods in four human buccal mucosa SCC Sq

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16

Smullen, Joanne. "An investigation into the in vitro fermentation of certain carbohydrates by the oral bacterium Streptococcus mutans and the effect of natural food ingredients on its growth in vitro." Thesis, University of Salford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248945.

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17

Rafati, Hassan. "In vitro and in vivo characterisation of biodegradable microparticles for vaccine delivery." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338533.

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18

Gangemi, Lavinia. "Studies on the development of in vitro human models of oral cancer." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327667.

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Kulkarni, Upendra D. "Optimization of porcine buccal mucosa for in vitro evaluation." Scholarly Commons, 2007. https://scholarlycommons.pacific.edu/uop_etds/652.

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Porcine buccal mucosa has been extensively used as in vitro model to study the permeability of drugs and assess their potential to deliver through buccal route. Porcine buccal mucosa is found to be very similar to human oral mucosa in structure and function. However, the in vitro permeation studies across porcine buccal mucosa show high variability which is mostly due to the various experimental and biological variables that are often overlooked while conducting such studies. The precise nature of the permeability barrier offered by the various tissue layers of buccal mucosa was investigated i

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20

Mohamad, Mohamad. "In vitro investigations into the antimicrobial and microecological effects of selected anti-plaque agents." Thesis, University of Manchester, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538505.

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The prevalence of oral diseases such as dental caries and periodontitis and the universal need for effective control of oral health has stimulated a great deal of interest in oral hygienic formulations both scientifically and commercially driven. Such formulations are normally deployed as complex formulations commonly containing antimicrobial actives together with excipients, where both classes of ingredients may contribute to the bacteriological effect of the oral hygienic product. However, the mode of action and/or the bacteriological and microecological effects of exposure of microorganisms

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21

Ly, Joseph Pang-Hoi. "Development of an oral microspherical formulation for bimodal in vitro release of theophylline." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29336.pdf.

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Luker, L. "The behaviour of normal and malignant oral keratinocytes in vitro and in vivo." Thesis, University of Bristol, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379571.

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Hunfjörd, Sylvia, and Jenny Olsson. "Phenotypic adaptation in early bacterial colonizers on oral surfaces - an in vitro study." Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19952.

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Orala bakterier, såsom de tidiga kolonisatörerna; Streptococcus gordonii, Streptococcus oralis, Streptococcus mitis och Actinomyces naeslundii uttrycker ett brett spektrum av ytadhesiner som möjliggör inbindning till receptorer i tandpellikeln. Saliv, gingivalt exudat (GCF) och kollagen I i cement på blottade rotytor erbjuder möjliga ytor i munhålan där bakterier kan adherera och bilda biofilm. Syftet med denna studie var att undersöka huruvida utvalda bakterier kan förändra genuttryck beroende på innehållet i olika ytor. Laborativa in vitro-försök genomfördes där de fyra bakteriearterna tillä

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MELLO, NADIA J. C. "Avaliação in vitro da resistência à tração de um sistema de retenção intracanal em condutos radiculares irradiados com laser de Er:YAG e de Nd:YAG." reponame:Repositório Institucional do IPEN, 2006. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11698.

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Made available in DSpace on 2014-10-09T12:54:53Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:06:54Z (GMT). No. of bitstreams: 1 12796.pdf: 440348 bytes, checksum: 5d7b85c92d4b0bf453b89e0590595d61 (MD5)<br>Dissertacao (Mestrado Profissionalizante em Lasers em Odontologia)<br>IPEN/D-MPLO<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP; Faculdade de Odontologia, Universidade de Sao Paulo, Sao Paulo

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SANTIN, Rosema. "Isolamento, identificação e suscetibilidade in vitro de leveduras isoladas da cavidade oral de fêmeas caninas." Universidade Federal de Pelotas, 2009. http://repositorio.ufpel.edu.br/handle/ri/2532.

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Made available in DSpace on 2014-08-20T14:37:57Z (GMT). No. of bitstreams: 1 dissertacao_rosema_santin.pdf: 3641963 bytes, checksum: d088da2fe7dd18329508c62dfe97ec75 (MD5) Previous issue date: 2009-02-26<br>The aims of this study was the oral cavity evaluation of females stray dogs from Pelotas-RS, as well as yeast isolation and identification from three different areas of this cavity, comparison of two technique of sample collection (swabs and curettes) and test the in vitro susceptibility of isolated yeasts against common oral antiseptics used in pets. Fifty-nine randomized animals were in

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Faria, Júnior Norberto Batista de [UNESP]. "Estudo in vitro de apicectomia e retropreparos realizados por diferentes métodos." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/90402.

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Made available in DSpace on 2014-06-11T19:24:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-04-28Bitstream added on 2014-06-13T19:52:08Z : No. of bitstreams: 1 fariajunior_nb_me_arafo.pdf: 2744351 bytes, checksum: d5a40b9a081c08ee1ecb555c255cffc7 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Este estudo objetivou: (1) comparar a topografia superficial e a interface entre a obturação e as paredes do canal de raízes seccionadas com laser, ultra-som ou broca; (2) avaliar o efeito do preparo retrógrado com retropontas ultra-sônicas ou laser na integri

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Louro, Rita Silvana Andreolli. "Avaliação \'in vitro\' da eficácia e estabilidade de enxagüatórios bucais remineralizantes." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-14122006-183702/.

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A Saúde Bucal está relacionada à exposição ao flúor, hábitos dietéticos e higiênicos menos cariogênicos, além de fatores sócio-econômico-culturais favoráveis. A melhor intervenção farmacêutica constitui-se em formular um agente fluoretado capaz de prevenir e/ou retardar o processo carioso. Procedeu-se a coleta de dentes terceiros molares inclusos que foram fragmentados e adaptados em suportes adequados para serem submetidos aos testes. Determinou-se o protocolo experimental baseado, seqüencialmente, em: avaliação da microdureza das amostras dentárias hígidas; desmineralização das mesmas; avali

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Faria, Júnior Norberto Batista de. "Estudo in vitro de apicectomia e retropreparos realizados por diferentes métodos /." Araraquara : [s.n.], 2008. http://hdl.handle.net/11449/90402.

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Orientador: Fabio Luiz Camargo Villela Berbert<br>Banca: Clóvis Monteiro Bramante<br>Banca: Mário Tanomaru Filho<br>Resumo: Este estudo objetivou: (1) comparar a topografia superficial e a interface entre a obturação e as paredes do canal de raízes seccionadas com laser, ultra-som ou broca; (2) avaliar o efeito do preparo retrógrado com retropontas ultra-sônicas ou laser na integridade da superfície apical; (3) e avaliar a espessura de dentina remanescente após retropreparos com laser ou ultra-som verificando sua correlação com o surgimento de trincas. Trinta dentes instrumentados e obturados

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Borges, Josiane Gonçalves. "Desenvolvimento de filmes de desintegração oral para liberação de compostos bioativos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/74/74132/tde-10072013-091914/.

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É crescente o interesse dos consumidores por produtos naturais com apelo funcional. Por isso tem se estudado novos veículos de liberação de compostos bioativos, como por exemplo, os filmes de desintegração oral. A própolis é uma fonte natural rica em compostos ativos, como por exemplo, os compostos fenólicos, que lhe confere atividade antimicrobiana e antioxidante. O colágeno hidrolisado pode apresentar diversos benefícios quando ingerido, como aumento da densidade óssea e representa uma boa fonte de peptídeos. Este trabalho teve como objetivo desenvolver e caracterizar os filmes de desintegra

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Khng, Kwang Yong Kelvin. "An in vitro evaluation of the marginal integrity of CAD/CAM interim crowns compared to conventional interim resin crowns." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/4863.

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CAD/CAM technology had evolved extensively from the time when it was first used clinically in the 1980s. Today, CAD/CAM technology can be used to fabricate crowns, design and mill fixed partial denture frameworks, set teeth and fabricate complete dentures as well as to mill interim restorations. An extensive literature review found many research studies on the evaluation of the accuracy of the CAD/CAM ceramic crowns as compared to other ceramic crowns but little research had been done to evaluate the accuracy of interim re

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Perakslis, Eric D. Lowman Anthony M. "Determination of the in vitro and in vivo oral drug delivery capabilities of complexation hydrogels /." Philadelphia, Pa. : Drexel University, 2006. http://hdl.handle.net/1860/1305.

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Yamamoto, Noriyuki, Yasushi Hayashi, Hideaki Kagami, et al. "Suicide gene therapy using adenovirus vector for human oral squamous carcinoma cell line In vitro." Nagoya University School of Medicine, 2005. http://hdl.handle.net/2237/5408.

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Hansson, Annette. "Modeling of multi-step oral carcinogenesis in vitro : assessment of growth, differentiation and apoptosis markers /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-445-3/.

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Cavalcante, Larissa Maria Assad. "Influencia da formulação de resinas compostas na resistencia a degradação intra-oral : estudo in vitro." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289754.

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Orientadores: Luiz Andre Freire Pimenta, Lourenço Correr Sobrinho<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-09T22:51:50Z (GMT). No. of bitstreams: 1 Cavalcante_LarissaMariaAssad_D.pdf: 536587 bytes, checksum: c97182efcf2800fc62ca9a1dc8ddea8b (MD5) Previous issue date: 2008<br>Resumo: Dentes naturais, bem como restaurações estão sujeitos à degradação inta-oral. Nas resinas compostas, além das interferências químicas, térmicas e mecânicas, a composição e a estrutura pós-cura são mecanismos considerados

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Padilha, Elias Carvalho. "Screening farmacocinético e estudos in vitro para a seleção de tiazolidinodionas promissoras à administração oral /." Araraquara, 2017. http://hdl.handle.net/11449/152521.

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Orientador: Rosangela Gonçalves Peccinini<br>Banca: Marina Galdino da Rocha Pitta<br>Banca: Anderson Rodrigo Moaraes de Oliveira<br>Banca: Marcelo Tadeu Marin<br>Banca: Marlus Chorilli<br>Resumo: As tiazolidinodionas (TZDs) são fármacos utilizados no tratamento de Diabetes Mellitus tipo 2 (DM2), seu mecanismo de ação é a ativação dos receptores PPAR-γ do núcleo celular. Além de sua atividade sobre o metabolismo glicídico e lipídico, há um particular interesse em sua atividade sobre a aterosclerose decorrente da síndrome metabólica que acomete estes pacientes. Tendo em vista a ampla aplicação d

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Young, Simon A. "The factors affecting liquid and semi-solid mucoadhesion to the oral cavity and oesophagus." Thesis, University of Portsmouth, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326988.

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Teixeira, Alrieta Henrique. "AÃÃo da terapia fotodinÃmica antimicrobiana sobre biofilmes orais crescidos in vitro e in situ." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4599.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>O tratamento das doenÃas ocasionadas por biofilmes orais envolve basicamente a remoÃÃo mecÃnica e o uso de antibiÃticos e agentes anti-sÃpticos os quais podem originar cepas resistentes aos antimicrobianos tradicionais. A Terapia FotodinÃmica Antimicrobiana (TFDA) apresenta-se como uma opÃÃo alternativa ao tratamento clÃssico, promovendo a morte bacteriana por meio da fotossensibilizaÃÃo dos componentes microbianos. Este estudo verificou a aÃÃo antimicrobia

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Ambrocio, Barrueto Enma Dajanne. "Microfiltración marginal de materiales de obturación temporal. Estudio in vitro." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2015. https://hdl.handle.net/20.500.12672/8933.

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Publicación a texto completo no autorizada por el autor<br>Determina el grado de microfiltración marginal de los materiales de obturación temporal en preparaciones cavitarias clase I según la clasificación de Black, a los 3, 5 y 7 días. Se usan 60 terceras molares superiores e inferiores que son extraídas por razones ortodóntica. Se prepara una cavidad de 4x4x4mm; se aislan usando barniz de uñas para sellar toda la pieza. Se dividen en cuatro grupos de 15 dientes según el material de obturación temporal usado (óxido de zinc -eugenol, policarboxilato de zinc, óxido de zinc/sulfato de zinc y óxi

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Malboubi, Saeid. "In vitro actions of platelet rich plasma and resolvin E1 on osteoblast and osteoclast activity." Thesis, Boston University, 2009. https://hdl.handle.net/2144/35619.

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Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2009 (Department of Periodontology and Oral Biology).<br>Includes bibliographic references: leaves 52-59.<br>Platelet-rich plasma (PRP) is a concentrated gel of platelets that contains several growth factors. Growth factors have been recognized as the part of PRP that play role in regeneration of the bone. It is not clear how these growth factors in PRP affect the bone regeneration. Resolvin El (RvEl; 5S,12R,18R-trihydroxyeicosapentaenoic acid) is an pro-resolving lipid mediator derived from omega-3 fatty acid eicosa

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Talens, Visconti Raquel. "Actividad antimicrobiana in vitro de nuevas 6-fluoroquinolonas de administración por vía oral. Relación estructura-actividad." Doctoral thesis, Universitat de València, 2002. http://hdl.handle.net/10803/9752.

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Las fluoroquinolonas se han convertido en agentes importantes en quimioterapia, especialmente en pacientes con infecciones graves que requieran fármacos potentes administrados por vía oral. Sin embargo, la aparición de resistencias a las quinolonas ha conducido a la búsqueda de nuevas moléculas, principalmente incluyendo modificaciones en el núcleo base de la benzopiridona, lo que ha llevado al hallazgo y comercialización de nuevas quinolonas, más activas pero, en muchos casos, más tóxicas, hasta el punto de que algunas han dejado de utilizarse o han sido retiradas del mercado tras haberse dem

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Zaid, Waleed. "In Vitro effects of bisophosphonates on oral squamous cell carcinoma BHY cells and BHY-induced osteoclasts." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114454.

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Objective: Oral squamous cell carcinoma (OSCC) is known to aggressively invade bone in a complex process that remains vague and poorly understood in many aspects. It is known that OSCC recruits osteoclasts, bone cells uniquely capable of bone destruction. The goal of this study was to assess the effects of soluble factors produced by OSCC on osteoclasts formation and responsiveness of bisphosphonates.Methods: BHY is the human cell line originally isolated from bone invasive OSCC. BHY OSCC cells were cultured and condition media was collected. Osteoclast formation from mouse murine monocytes R

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Qadir, Mohammad Siddique. "In vivo in vitro evaluation of predictive oral controlled release formulation to the lower intestinal tract." Thesis, University of Strathclyde, 2012. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=16805.

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Delvadia, Poonam. "A NOVEL BIORELEVANT IN VITRO SYSTEM TO PREDICT THE IN VIVO PERFORMANCE OF ORAL TRANSMUCOSAL PRODUCTS." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3173.

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In vitro dissolution, release and permeation testing is a common practice during drug product research and development. These in vitro tests, if predictive, are referred to as biorelevant tests and can play diverse roles to facilitate and expedite product development in a cost effective manner. Oral transmucosal products (OTPs) are currently tested using compendial and modified in vitro tests which may or may not be good predictors of in vivo performance due to a lack of biorelevance. A critical need for a broadly applicable and biorelevant in vitro system for OTPs has been expressed in the li

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AMORIM, T. C. "AVALIAÇÃO In Vitro da Sensibilidade do Microbioma Oral de Cães Labradores Retrievers Frente a Extratos Vegetais." Universidade Federal do Espírito Santo, 2018. http://repositorio.ufes.br/handle/10/7809.

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Made available in DSpace on 2018-08-01T22:57:00Z (GMT). No. of bitstreams: 1 tese_9925_THAYS DE CARVALHO AMORIM BOLZAN.pdf: 1298409 bytes, checksum: 1b9232f05388887f0ac9c264eaf90331 (MD5) Previous issue date: 2018-02-28<br>O presente estudo teve como objetivo avaliar a atividade antimicrobiana in vitro dos extratos das espécies: Anacardium ocidentalis; Harpagophytum procumbens; Momordica charantia L.; Punica granatum; Psidium guajava L.; Stryphnodendron adstringens e Uncaria tomentosa, frente ao microbioma oral de 12 cães Labradores retriviers. Para isso, utilizaram-se extratos polares das a

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Väyrynen, O. (Otto). "Factors affecting aggressive oral tongue cancer invasion and development of in vitro models for chemoradiotherapy assay." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526222813.

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Abstract Tumor associated macrophages (TAMs) are linked to the invasion of oral tongue squamous cell carcinoma (OTSCC). We modified THP-1 leukemia cells to M1 (inflammatory), M2 (TAM-like) and R848 (imidazoquinoline-treated) type macrophages in order to examine their interactions with OTSCC-cells (HSC-3) by using different kinds of in vitro migration and invasion models. We observed that interaction of TAM-resembling M2-type macrophages with HSC-3 cells induced invasion and migration, whereas the influence of M1 macrophages reduced them. Patient response to chemoradiotherapy is highly reliant

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Martins, Emerson Alves. "Avaliação in vitro de danos causados ao esmalte usando modelo biomecânico para simular lesões não cariosas." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/23/23140/tde-02092013-150515/.

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OBJETIVO: A etiologia das LNCs é complexa e não está totalmente esclarecida e parecem influir e interagir na sua formação fatores tão diversos como a concentração de tensões, a presença de ácidos de diversas origens e mecanismos tribológicos variados. O objetivo deste estudo in vitro foi avaliar se há diferenças na influência da tensão de tração, de compressão e da escovação na profundidade da lesão, microdureza e rugosidade do esmalte bovino submetido a desafio ácido. (O trabalho constituiu-se da avaliação dos danos ao esmalte bovino submetido a um desafio ácido erosivo e desafio abrasivo) co

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Pereira, Eliane dos Santos. "ExpressÃo gÃnica de Streptococcus mutans em biofilmes produzidos in vitro submetidos Ã terapia fotodinÃmica antimicrobiana." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5759.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Os estÃgios iniciais da formaÃÃo das lesÃes de cÃrie em humanos estÃo relacionados diretamente com a presenÃa de Streptococcus mutans no biofilme dental. O tratamento das doenÃas ocasionadas por biofilmes orais envolve basicamente a remoÃÃo mecÃnica e o uso de antibiÃticos e agentes anti-sÃpticos os quais podem originar cepas resistentes aos antimicrobianos tradicionais. A Terapia FotodinÃmica Antimicrobiana (TFDA) apresenta-se como uma opÃÃo alternativa ao tratamento clÃssico, promovendo a morte bacteriana por meio da fotossenssib

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Pellicioli, Ana Carolina Amorim. "Efeito da fototerapia laser no preparo in vitro de queratinócitos bucais." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/143466.

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A fototerapia laser (FTL) tem sido usada clinicamente para auxiliar na cicatrização de inúmeras doenças bucais, especialmente no tratamento de lesões ulceradas. Os mecanismos celulares através dos quais o laser é capaz de promover a bioestimulação não são completamente compreendidos. Dessa forma, o objetivo do presente estudo foi avaliar in vitro o efeito da FTL no comportamento de queratinócitos bucais no processo de cicatrização. Células epiteliais bucais (NOK-SI) foram cultivadas sob duas condições nutricionais: suplementadas com 10% de soro fetal bovino (FBS) e sob déficit nutricional (2%

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Tandt, Ludo Alfons Germaan Luc. "The evaluation of indomethacin and theophylline oral controlled/modified-release dosage forms in vitro-in vivo correlations." Thesis, Rhodes University, 1992. http://hdl.handle.net/10962/d1003272.

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Over the past few decades many researchers have investigated the utility of in vitro - in vivo correlations for the assessment of dosage forms. These investigations are, however, dependent on reproducible dissolution data and well conducted biostudies in order to establish meaningful and robust correlations. Despite the fact that the establishment of such correlations is perhaps idealistic, considerable interest has still been shown in this area of research. Various Controlled/Modified Release Dosage Forms (CMRD's) of theophylline, a weakly basic drug, and indomethacin, a weakly acidic drug, w

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Pestana, Kelly Chrystina [UNESP]. "Microemulsões biocompatíveis de anfotericina B para administração oral: estudo estrutural, liberação in vitro e farmacocinética pré-clínica." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/106310.

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Made available in DSpace on 2014-06-11T19:35:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-08-20Bitstream added on 2014-06-13T18:46:55Z : No. of bitstreams: 1 pestana_kc_dr_arafcf.pdf: 1397611 bytes, checksum: 139f2c10e325976c56a9928f8e54e882 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Anfotericina B (AmB) é o fármaco de escolha para o tratamento das infecções fúngicas invasivas, importante causa de morbidade e mortalidade em pacientes imunodeprimidos. A toxicidade da AmB na forma convencional tem estimulado o desenvolvimento de novas formulaçõ

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