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Artykuły w czasopismach na temat „Including sustained release”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Prajapat, Priyanka, Dilip Agrawal, and Gaurav Bhaduka. "A brief overview of sustained released drug delivery system." Journal of Applied Pharmaceutical Research 10, no. 3 (2022): 05–11. http://dx.doi.org/10.18231/j.joapr.2022.10.3.5.11.

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The most popular and patient-friendly method of drug administration is often thought to be the oral route of administration. Compared to conventional release formulations, advancements in formulation technology, including modified release dosage forms or sustained release oral dosage forms, have been extensively accepted. A sustained release dosage form provides a prolonged release of the drug over an extended period, thereby giving better patient compliance and enhanced bioavailability. Sustain release systems are considered a wiser approach for drugs with short half-lives requiring repeated

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Kalyani Shelar, Gauri Mahajan, Nikita Pagare, Prachiti Sahane, and Sakshi Bhosale. "Review on Sustained Release Tablet." International Journal of Scientific Research in Science and Technology 11, no. 6 (2024): 698–708. https://doi.org/10.32628/ijsrst241161126.

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This review highlights the advantages of SR formulations, including reduced side effects, enhanced drug utilization, improved treatment efficacy, and better patient compliance. Key considerations for developing sustained release tablet involve the drug's physicochemical properties and biological factors, such as absorption and metabolism. Various formulation strategies, including diffusion-controlled, dissolution-controlled, and osmotic systems, are discussed alongside essential evaluation parameters like density, hardness, and in-vitro drug release profiles. The outlook for sustained release

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Karim, Samira, Mohiuddin Ahmed Bhuiyan, and Md Sohel Rana. "Formulation and in vitro Evaluation of Glimepiride Sustained Release Tablets: Comparison with Immediate Release Tablets." Bangladesh Pharmaceutical Journal 18, no. 2 (2015): 157–62. http://dx.doi.org/10.3329/bpj.v18i2.24315.

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This work aims at the design of a sustained release formulation of glimepiride which is currently available in the treatment of type 2 diabetes mellitus and to investigate the effect of polymers on the release profile of glimepiride. Glimepiride sustained release tablets were prepared by direct compression method using different ratios of various release retarding polymers such as carbopol, ethyl cellulose, methocel K4 MCR, methocel K15 MCR, methocel K100 MCR and xanthum gum. These formulations were also compared with glimepiride immediate release tablets. The prepared tablets were subjected t

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Du, Guangsheng, and Xun Sun. "Current Advances in Sustained Release Microneedles." Pharmaceutical Fronts 02, no. 01 (2020): e11-e22. http://dx.doi.org/10.1055/s-0040-1701435.

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AbstractMicroneedles have been extensively investigated for intradermal delivery of drugs and vaccines due to advantages including high skin delivery efficiency, improved patient compliance, and potential for self-administration. However, traditional microneedles cannot regulate the release kinetics of payloads, limiting therapeutic utility of the biotherapeutics. Recently, several types of microneedles with sustained release properties, including slow-dissolving microneedles made of hydrophilic polymers, degradable microneedles made of hydrophobic polymers, and bioresponsive microneedles made

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Taghizadeh Davoudi, Ehsan, Mohamed Ibrahim Noordin, Ali Kadivar, Behnam Kamalidehghan, Abdoreza Soleimani Farjam, and Hamid Akbari Javar. "Preparation and Characterization of a Gastric Floating Dosage Form of Capecitabine." BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/495319.

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Gastrointestinal disturbances, such as nausea and vomiting, are considered amongst the main adverse effects associated with oral anticancer drugs due to their fast release in the gastrointestinal tract (GIT). Sustained release formulations with proper release profiles can overcome some side effects of conventional formulations. The current study was designed to prepare sustained release tablets of Capecitabine, which is approved by the Food and Drug Administration (FDA) for the treatment of advanced breast cancer, using hydroxypropyl methylcellulose (HPMC), carbomer934P, sodium alginate, and s

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Rohan, Waghmare*1 Surekha Khamkar2. "Formulation and Evaluation of Sustained Release Metronidazole Tablet." International Journal of Scientific Research and Technology 2, no. 5 (2025): 355–63. https://doi.org/10.5281/zenodo.15421602.

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Metronidazole, an antibiotic commonly used to treat infections caused by anaerobic bacteria and certain protozoa, has a broad spectrum of activity. However, its frequent dosing regimen due to its short half-life often leads to poor patient compliance and fluctuations in plasma drug concentrations. The development of sustained-release formulations of metronidazole aims to improve its therapeutic effectiveness, enhance patient adherence, and minimize side effects.This study focuses on the formulation and evaluation of sustained-release (SR) tablets of metronidazole. The SR formulation was design

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Xiang, Aishuang, and Anthony J. McHugh. "Quantifying sustained release kinetics from a polymer matrix including burst effects." Journal of Membrane Science 371, no. 1-2 (2011): 211–18. http://dx.doi.org/10.1016/j.memsci.2011.01.050.

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Ujjwal, Kukreti, Nainwal Nidhi, Ale Yogita, et al. "Release Kinetic of Sustained Release Matrix Tablet of Linezolid Containing Polymer Blend." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1479–84. http://dx.doi.org/10.25258/ijpqa.15.3.60.

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Tuberculosis (TB) is a bacterial infection mainly affecting the lungs. TB is a major health problem worldwide and the occurrence of extensively drug-resistant TB (XDR-TB) and multidrug-resistant TB (MDR-TB) offers considerable hurdles to effective treatment and disease management. The growth of treatment-resistant Mycobacterium TB strains has prompted the investigation of alternate therapeutic techniques, including the application of sustained drug delivery. Sustained-release drugs reduce the need for frequent dosing can extend the effects of linezolid by 8 to 12 hours, thus improving the pati

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Thanh, Duyen Nguyen Thi, Duc Hoang Van, Minh Vo Xuan, Xuan Dam Thanh Thanh, and Tung Bui Thanh. "Design and Optimization of Hydrophilic Matrix-based Sustained Release Felodipine Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 3 (2018): 4136–44. http://dx.doi.org/10.37285/ijpsn.2018.11.3.8.

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Felodipine is a calcium channel blocker used for hypertensive and unstable angina treatments. The sustained release formulations of felodipine have advantages of achieving good therapeutic effects, increasing the bioavailability, decreasing dosing times per day and reducing side effects.The aim of our study was to study the formulation screening, then use an experiment design for formulating a hydrophilic matrix sustained release tablet of felodipine. Methods: The optimization process had the influences of the chosen excipients (including HPMC E4M, HPMC E15LV) on the drug release. Three depend

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Guan, Ya, Hong Niu, Zhongting Liu, et al. "Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation." Science Advances 7, no. 35 (2021): eabj0153. http://dx.doi.org/10.1126/sciadv.abj0153.

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Nonhealing diabetic wounds are common complications for diabetic patients. Because chronic hypoxia prominently delays wound healing, sustained oxygenation to alleviate hypoxia is hypothesized to promote diabetic wound healing. However, sustained oxygenation cannot be achieved by current clinical approaches, including hyperbaric oxygen therapy. Here, we present a sustained oxygenation system consisting of oxygen-release microspheres and a reactive oxygen species (ROS)–scavenging hydrogel. The hydrogel captures the naturally elevated ROS in diabetic wounds, which may be further elevated by the o

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Formulation, and Evaluation of Sustained Release Pellets of Oral Antidiabetic Agent by Using Natural Polymer, and Giram* Diptee Bhagwat Dr. K. R. Biyani Rutuja. "Formulation and Evaluation of Sustained Release Pellets of Oral Antidiabetic Agent by Using Natural Polymer." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3060–65. https://doi.org/10.5281/zenodo.15458667.

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In the present study we concluded that, the formulation and assessment of sustained release tablets utilizing natural polymers are the main topics of the review.  Long-term medication release is the goal of sustained release (SR) dose forms, which increase patient compliance and therapeutic efficacy.  The benefits and drawbacks of sustained release tablets are covered in the study along with preparation techniques and the many natural polymers that are utilized in these formulations.  Natural polymers that have been shown to improve drug release characteristics include chitosan,

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Mangesh, Dagale* Dr. Nilesh Gorde Kartik Shinde Ashwini Karnakoti Prajwal Birajdar. "Current Trends and Challenges in Sustained-Release Tablet Formulations: A Comprehensive Review." International Journal of Scientific Research and Technology 2, no. 1 (2025): 266–76. https://doi.org/10.5281/zenodo.14678430.

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The development of sustained release (SR) matrix tablets has garnered significant attention in modern pharmaceutical research owing to their ability to maintain prolonged therapeutic action, improve patient compliance, and enhance drug bioavailability. Among various approaches for achieving sustained release, the use of natural gums as matrix-forming agents has emerged as a promising strategy due to their biocompatibility, biodegradability, non-toxicity, and economic viability. This review focuses on the formulation, evaluation, and applications of SR matrix tablets, with a special emphasis on

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Sahu, Dr Gyanesh Kumar. "A Review on Role of Sustained Release Tablets in Improving Patient Compliance and Therapeutic Outcomes." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 12 (2024): 1–7. https://doi.org/10.55041/ijsrem39580.

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Sustained release tablets represent a significant advancement in pharmaceutical drug delivery, offering controlled and prolonged release of active ingredients to enhance therapeutic outcomes. This novel approach addresses the limitations of conventional dosage forms by maintaining consistent plasma drug levels, reducing dosing frequency, and improving patient compliance. Sustained release systems utilize various technologies, including matrix systems, reservoir systems, and osmotic pumps, to regulate drug release over an extended period. This review provides a comprehensive analysis of the des

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Jayashree, Bhamre* Shraddha Bhavsar Dr. Gokul Talele Bhushan Shewale. "A Systematic Review on Sustained Release Matrix Tablet." International Journal of Pharmaceutical Sciences 2, no. 8 (2024): 2555–64. https://doi.org/10.5281/zenodo.13212215.

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The abstract of the document provides an overview of sustained release drug delivery systems. It emphasizes the goal of delivering therapeutic levels of drugs to specific body sites over extended periods. The document discusses the increasing interest in sustained release systems due to high costs of developing new drugs, patent expirations, discovery of new polymers, and improvements in therapeutic efficiency and safety. Various types of matrix tablets, such as hydrophilic, fat-wax, plastic, biodegradable, and mineral matrices, are classified based on their properties and methods of drug rele

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Gayke, Amol U* Aglawe Sachin B. Thakare Girish Kale Nitin Gujarathi Tanmay jagdale Ashok Khandagle Sandip. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE MICROSPHERES OF ROSIN CONTAINING ATORVASTATIN CALCIUM." Indo American Journal of Pharmaceutical Sciences 04, no. 10 (2017): 3503–9. https://doi.org/10.5281/zenodo.1002943.

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Atorvastatin Calcium was microencapsulated using rosin by o/w emulsion solvent evaporation technique. The effect of three formulation variables including the drug:polymer ratio, emulsifier (polyvinyl alcohol) concentration and organic solvent (dichloromethane) volume were examined. The prepared batches were characterized for microspheres particle size distribution, encapsulation efficiency and in vitro release behavior. The study reveals that drug:polymer ratio had a considerable effect on the entrapment efficiency, however particle size distribution of microspheres was more dependent on the v

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Florez, Daniela, Alyssa J. Young, Kerlly J. Bernabé, James M. Hyman, and Zhuolin Qu. "Modeling Sustained Transmission of Wolbachia among Anopheles Mosquitoes: Implications for Malaria Control in Haiti." Tropical Medicine and Infectious Disease 8, no. 3 (2023): 162. http://dx.doi.org/10.3390/tropicalmed8030162.

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Wolbachia infection in Anopheles albimanus mosquitoes can render mosquitoes less capable of spreading malaria. We developed and analyzed a mechanistic compartmental ordinary differential equation model to evaluate the effectiveness of Wolbachia-based vector control strategies among wild Anopheles mosquitoes in Haiti. The model tracks the mosquito life stages, including egg, larva, and adult (male and female). It also accounts for critical biological effects, such as the maternal transmission of Wolbachia through infected females and cytoplasmic incompatibility, which effectively sterilizes uni

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Sun, Yi-yang, Ya-jing Ni, Run-jia Wang, et al. "Establishment and Validation of a Transdermal Drug Delivery System for the Anti-Depressant Drug Citalopram Hydrobromide." Molecules 29, no. 4 (2024): 767. http://dx.doi.org/10.3390/molecules29040767.

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To enhance the bioavailability and antihypertensive effect of the anti-depressant drug citalopram hydrobromide (CTH) we developed a sustained-release transdermal delivery system containing CTH. A transdermal diffusion meter was first used to determine the optimal formulation of the CTH transdermal drug delivery system (TDDS). Then, based on the determined formulation, a sustained-release patch was prepared; its physical characteristics, including quality, stickiness, and appearance, were evaluated, and its pharmacokinetics and irritation to the skin were evaluated by applying it to rabbits and

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Ben-Noun, Liubov. "Acute Asthma Associated with Sustained-Release Verapamil." Annals of Pharmacotherapy 31, no. 5 (1997): 593–95. http://dx.doi.org/10.1177/106002809703100514.

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OBJECTIVE: TO describe a patient with asymptomatic bronchial asthma and hypertension who developed an acute asthma attack after receiving sustained-release verapamil. CASE SUMMARY: A 66-year-old white woman with a 10-year history of hypertension and bronchial asthma was switched from immediate-release verapamil hydrocloride 40 mg tid to sustained-release verapamil 240 mg/d po for better hypertension control. After taking the first tablet, she developed dyspnea, cough, and wheezing. Antiasthmatic medications were prescribed, but the asthma symptoms did not improve. She continued taking verapami

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Singh, Ajay, Manoj Kumar Goyal, and Yogendra Shakya. "Formulation and Evaluation of Control Release Clopidogrel Bisulphate Microspheres." Journal of Biomedical and Pharmaceutical Research 13, no. 5 (2024): 17–34. http://dx.doi.org/10.32553/jbpr.v13i5.1123.

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This study focuses on the formulation and evaluation of controlled-release microspheres for clopidogrel bisulfate, an antiplatelet agent widely used in the prevention of cardiovascular events. The objective was to develop a sustained-release delivery system that enhances the therapeutic efficacy of clopidogrel while improving patient compliance through reduced dosing frequency. Various biocompatible and biodegradable polymers, including poly (lactic-co-glycolic acid) (PLGA) and HPMC, were utilized to fabricate the microspheres using the solvent evaporation technique. The resulting microspheres

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Zakia, Dr. Rahman Gul, Dr. Syed Umer Jan, et al. "DEVELOPMENT AND EVALAUTION OF LORATADINE GEL FOR TRANSDERMAL DRUG DELIVERY." Physical Education, Health and Social Sciences 3, no. 2 (2025): 506–13. https://doi.org/10.63163/jpehss.v3i2.314.

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Abstract Objective: This research was conducted to develop and evaluate sustained release topical gels containing Loratadine, olive oil used as penetration enhancer with various concentrations to see its effect on drug release concentration. Method Several gel formulations were prepared using hydrophilic polymers including Carbopol 940, to investigate their impact on drug release characteristics and physicochemical properties. The formulations were assessed for pH, spreadability, viscosity, drug content, and in vitro release profile. The study used sophisticated advanced techniques including D

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Kelly, Shannon, Anjali Hirani, Vishal Shahidadpury, et al. "Aflibercept Nanoformulation Inhibits VEGF Expression in Ocular In Vitro Model: A Preliminary Report." Biomedicines 6, no. 3 (2018): 92. http://dx.doi.org/10.3390/biomedicines6030092.

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Age-related macular degeneration (AMD) is one of the leading causes of blindness in the United States, affecting approximately 11 million patients. AMD is caused primarily by an upregulation of vascular endothelial growth factor (VEGF). In recent years, aflibercept injections have been used to combat VEGF. However, this treatment requires frequent intravitreal injections, leading to low patient compliance and several adverse side effects including scarring, increased intraocular pressure, and retinal detachment. Polymeric nanoparticles have demonstrated the ability to deliver a sustained relea

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Abhishek, Bhosale*1 Priti Shinde2. "Formulation and Evaluation of Metformin HCL Gastroretentive Floating Sustained Released Tablet." International Journal of Scientific Research and Technology 2, no. 6 (2025): 06–16. https://doi.org/10.5281/zenodo.15566055.

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The Metformin HCl Gastroretentive Floating Sustained Release Tablet was formulated using the Wet Granulation method. This tablet incorporates an effervescent system, where Hydroxypropyl Methylcellulose (HPMC) K 100, a swellable polymer, facilitates the floating mechanism. Sodium bicarbonate is employed to create the effervescent system. A synergistic combination of HPMC K 100 and Xanthan Gum enhances the sustained release profile of the formulation. The prepared gastroretentive floating tablets were evaluated for various pharmaceutical parameters, including bulk density, tapped density, angle

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Jian, Hong Lei, Li Wei Zhu, Wei Ming Zhang, Xiang Qi, and Jian Xin Jiang. "Evaluation of Galactomannan from Gleditsia Sinensis Lam. as Sustained Release Material in Colonic Drug Delivery." Advanced Materials Research 146-147 (October 2010): 589–98. http://dx.doi.org/10.4028/www.scientific.net/amr.146-147.589.

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The galactomannan from endosperm of G. sinensis seeds was used as sustained release material in the matrix tablets prepared at different concentration of 5, 10 and 15 % corresponding to formulations of G5, G10 and G15, for the release of theophylline. The drug release behaviors of the systems were investigated, including the swelling and morphological studies and texture analysis. The dissolution tests were conducted in 0.1 M hydrochloric acid and pH 6.8 phosphate buffered saline. The results of release studies demonstrated that G10 with 10 % galactomannan concentration showed a better control

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Thapa, Chhitij, and Roma Chaudhary. "Formulation and In-Vitro Evaluation of Sustained Release Matrix Tablets of Domperidone." Journal of Universal College of Medical Sciences 8, no. 02 (2020): 40–45. http://dx.doi.org/10.3126/jucms.v8i02.34286.

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INTRODUCTION Domperidone is a unique compound with gastro kinetic and antiemetic effects. It is used in the management of disorder by impaired motility like gastroesophageal reflux (in some instances), gastroparesis, dyspepsia, heartburn, epigastric pain, nausea, vomiting, and colonic inertia. The sustained release system is a widely accepted approach for slow drug release over an extended period to address the challenges of conventional oral delivery, including dosing frequency, drug safety, and efficacy. The study aims to formulate a domperidone sustained release tablet and compare the

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Ansary, Wasim Akter, Priya Rani Paul, Md Salvin Morshed, Md Raihan Sarker, Md Abdur Rahim, and Md Shahadat Hossain. "Design and Formulation of Modified-Release Bilayer Tablets of Rosuvastatin and Ezetimibe." Bangladesh Pharmaceutical Journal 28, no. 1 (2025): 70–82. https://doi.org/10.3329/bpj.v28i1.79467.

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Cardiovascular disease (CVD) causes a significant number of morbidity and mortality worldwide, primarily driven by dyslipidemia and abnormal lipid levels. Effective management of hyperlipidemia and CVD typically involves using various pharmacological agents, including statins (like atorvastatin and rosuvastatin), cholesterol absorption inhibitors (like ezetimibe), and fibrates. The combined use of these agents has been shown to decrease cardiovascular events effectively over a long duration. This study formulated and designed a bilayer tablet containing sustained-release formulations of rosuva

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Encinas-Basurto, David, John P. Konhilas, Robin Polt, Meredith Hay, and Heidi M. Mansour. "Glycosylated Ang-(1-7) MasR Agonist Peptide Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles and Microparticles in Cognitive Impairment: Design, Particle Preparation, Physicochemical Characterization, and In Vitro Release." Pharmaceutics 14, no. 3 (2022): 587. http://dx.doi.org/10.3390/pharmaceutics14030587.

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Heart failure (HF) causes decreased brain perfusion in older adults, and increased brain and systemic inflammation increases the risk of cognitive impairment and Alzheimer’s disease (AD). Glycosylated Ang-(1-7) MasR agonists (PNA5) has shown improved bioavailability, stability, and brain penetration compared to Ang-(1-7) native peptide. Despite promising results and numerous potential applications, clinical applications of PNA5 glycopeptide are limited by its short half-life, and frequent injections are required to ensure adequate treatment for cognitive impairment. Therefore, sustained-releas

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Samrudh, Shinde Shivaji Patil Namrata Satkar Pritam Salokhe Nilesh Chougule. "Formulation And Evaluation Of Floating Sustain Release Tablet Of Ranolazine." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1505–16. https://doi.org/10.5281/zenodo.12788828.

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This research focuses on the formulation and evaluation of floating sustained-release tablets of Ranolazine, an anti-anginal agent with poor bioavailability and short half-life. The tablets were prepared using various polymers such as hydroxypropyl methylcellulose (HPMC) and sodium alginate to achieve controlled drug release and prolonged gastric residence time. The formulation was optimized using a 32 full factorial design to study the effect of independent variables like polymer concentration and tablet hardness on drug release kinetics and floating behavior. The prepared tablets exhibited e

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Gore, Aarti* Gondkar Tejas Gorde Mahesh Mhaske Manjusha. "Formulation And Evaluation of Effervescent Based Gastro Retentive Floating Tablets of Nifedipine." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1458–72. https://doi.org/10.5281/zenodo.15379767.

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This study aims to develop and assess gastro-retentive floating tablets of nifedipine, designed to sustain drug release for up to 12 hour. The formulation utilize natural polymers, including xanthan gum and gum tragacanth employing a direct compression method. An effervescent gas generating agent, consisting of sodium bicarbonate, was incorporated to facilitate the floating capability of the tablets. The prepared gastroretentive floating tablets underwent a series of evaluation, including drug-excipient compatibility studies, weight variation, thickness, hardness, content uniformity, in vitro

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Harshdeep, Desai* Tushar Rukari Rashmi Mahabal Dr. Vijay Jagtap. "Beyond Conventional: Recent Advancement on Floating Drug Delivery Systems: An Approach to Oral Controlled and Sustained Drug Delivery Via Gastric Retention." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 2971–94. https://doi.org/10.5281/zenodo.14546659.

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Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. Different innovative approaches like magnetic field assisted gastro-retention, plug type swelling system, High-Density Systems, muco-adhesion technique, floating system with or without effervescence are being applied to fabricate GRDDS.

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Ranjeet, Singh* Dr. Amit Chaudhary. "Coating Techniques for Sustained Release Pellet Dosage Forms: Strategies for Achieving Zero-Order Release Kinetics." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 477–83. https://doi.org/10.5281/zenodo.15334874.

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The pursuit of zero-order drug release has become a key objective in the design of sustained release (SR) oral dosage forms, aiming to maintain constant plasma drug levels and enhance therapeutic efficacy. Pellet-based multiparticulate systems offer significant advantages in controlled drug delivery, including uniform distribution in the gastrointestinal tract, reduced risk of dose dumping, and flexible formulation design. Central to achieving desired release profiles is the application of functional polymer coatings that regulate drug diffusion. This review comprehensively explores coating te

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Shibata, Nobuhito, Asako Nishumura, Kazumasa Naruhashi, Yurie Nakao, and Rieko Miura. "Preparation and pharmaceutical evaluation of new sustained-release capsule including starch-sponge matrix (SSM)." Biomedicine & Pharmacotherapy 64, no. 5 (2010): 352–58. http://dx.doi.org/10.1016/j.biopha.2009.09.019.

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Matejkova, J., and P. Podhorec. "Sustained drug delivery system in fish and the potential for use of PLGA microparticles: a review." Veterinární Medicína 64, No. 7 (2019): 287–93. http://dx.doi.org/10.17221/161/2018-vetmed.

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Many fish species display some form of reproductive disorder in captivity. Captive fish reared in conditions outside the natural spawning environment show a failure of the pituitary to release the maturational gonadotropin luteinizing hormone thus necessitating administration of the hormone to induce spawning. A controlled sustained-release delivery system can conquer the issue of short half-life of gonadotropin releasing hormone (GnRH) in blood and avoid the necessity of using re-injections. Sustained release of GnRHa can induce long-term enhancement in semen production and multiple spawning

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Prasanna, Babu Racheeti A. Lakshmanarao L. Bhushan kumar B. .Yellamanda Y.Ramya. "Development And Evaluation Of Sustained Release Venlafaxine Hydrochloride Tablets Using HPMC And SCMC Matrix Systems"-A Comprehensive Review." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 514–24. https://doi.org/10.5281/zenodo.13910760.

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This study investigates the sustained release behavior of venlafaxine hydrochloride, an antidepressant agent, using Hydroxypropyl Methylcellulose (HPMC) and Sodium Carboxymethyl Cellulose (SCMC) as matrix-forming polymers. The research aimed to develop a once-daily sustained-release tablet formulation of venlafaxine hydrochloride. All formulations were prepared by direct compression and evaluated for various physical parameters, including weight uniformity, active ingredient content, friability, hardness, thickness, and in vitro dissolution profile. Dissolution studies were conducted using a U

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Mondal, Nita. "THE ROLE OF MATRIX TABLET IN DRUG DELIVERY SYSTEM." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 1. http://dx.doi.org/10.22159//ijap.2018v10i1.21935.

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Matrix tablet is an important tool for controlled and sustained release dosage forms. The oral route remains the most common route for the administration of drugs. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. The hydrophilic polymer matrix is widely used in this dosage form. The use of different polymers in controlling the release of drugs has become the most important tool in the formulation of matrix tablets. The drug releases by both dissolution-controlled as well as diffusion-controlled mechanisms from the matrix. The development of oral controll

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Nalbadis, Anastasios, Marie-Luise Trutschel, Henrike Lucas, Jana Luetzkendorf, Annette Meister, and Karsten Mäder. "Selection and Incorporation of siRNA Carrying Non-Viral Vector for Sustained Delivery from Gellan Gum Hydrogels." Pharmaceutics 13, no. 10 (2021): 1546. http://dx.doi.org/10.3390/pharmaceutics13101546.

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The local controlled release of siRNA is an attractive and rational strategy to enhance and extend the effectiveness of gene therapy. Since naked and unmodified siRNA has a limited cell uptake and knockdown efficiency, the complexation of siRNA with non-viral carriers is often necessary for the delivery of bioactive RNA. We evaluated the performance of three different non-viral siRNA carriers, including DOTAP lipoplexes (DL), chitosan polyplexes (CP), and solid lipid complexes (SLC). The physicochemical properties of the siRNA-nanocarriers were characterized by dynamic light scattering and gel

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Avinash, V. Dhobale, Siddaiah M., Shaileh M., and Madhu Babu A. "Formulation, Evaluation and Comparison of Sustained Release Matrix Tablet of Losartan Potassium Using Natural Polymers." American Journal of PharmTech Research 13, no. 03 (2023): 39–53. https://doi.org/10.5281/zenodo.8046928.

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ABSTRACT The aim of this research work was to Evaluation of Some Natural Polymer used as Sustained Release Matrix Tablet, any pharmaceutical formulation contains two ingredients one is the active ingredient and other is an excipients. An excipients help in the manufacturing of dosage form and it also improves physicochemical parameters of the dosage form. Polymers play an important role as excipients in any dosage form. They influence drug release and should be compatible, non-toxic, stable, economic etc. and develop a fixed Dose Combination product in a two different strength using same blend

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Ikoma, Toshiyuki, Tomohiko Yoshioka, Satoshi Nakamura, et al. "Rigid Hydroxyapatite-Alginate Beads for Sustained Release of Paclitaxel." Key Engineering Materials 361-363 (November 2007): 535–38. http://dx.doi.org/10.4028/www.scientific.net/kem.361-363.535.

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Rigid hydroxyapatite (HAp)-alginate beads were prepared as drug delivery carriers for an anti-cancer drug, paclitaxel (Taxol). Paclitaxel was loaded into the HAp microparticle in process of a spray-drying technique. The HAp-alginate beads including paclitaxel were obtained by a droplet method into barium solution as ionic cross-linkage and dehydration. Cross-sectional analyses indicated the homogeneity of HAp microparticles and barium ions inside the bead. The ratio of alginate to HAp in the beads dominated both mechanical and swelling properties. Drug-release experiment demonstrated the susta

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M., Durgarao*, Lakshmi Kavya G., Bhanu Mallika A.V., Srivinay G., Ravi P., and Lahari V. "FORMULATION AND EVALUATION OF PROLONGED RELEASE GEMFIBROZIL TABLETS." World Journal of Pharmaceutical Science and Research 3, no. 3 (2024): 325–33. https://doi.org/10.5281/zenodo.12732807.

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The development of prolonged-release formulations of pharmaceuticals is essential for enhancing therapeutic efficacy and patient compliance. This study focuses on the formulation and evaluation of prolonged-release Gemfibrozil tablets, a lipid-regulating agent used in the management of hyperlipidemia. The primary objective was to design a tablet that ensures sustained release of Gemfibrozil, thereby maintaining a consistent plasma concentration over an extended period. The formulation process involved the selection of appropriate polymers and excipients to achieve the desired release profile.

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G. Ingle, Tushar Kumar, Shrikant D. Pande, Sandeep Atram, Nishant Bobade, and Vikrant Wankhede. "Formulation and Evaluation of Microspheres for Colon Targeted Drug Delivery Using Anthelminthics Drugs." Asian Journal of Pharmaceutical Research and Development 11, no. 4 (2023): 36–45. http://dx.doi.org/10.22270/ajprd.v11i4.1283.

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The objective of this study was to develop sustained release microspheres for colon-targeted drug delivery system to enhance therapeutic efficacy while minimizing systemic side effects. The controlled and prolonged release of drugs in the colon can significantly improve the treatment outcomes for various colon-related diseases. Microspheres, small spherical particles with sizes ranging from 1 to 1000 micrometers, were formulated using biodegradable polymers and natural materials to ensure biocompatibility and controlled drug release. The formulation process involved the selection of appropriat

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Wang, LiNa, Xiao Lin, YanLong Hong, Lan Shen, and Yi Feng. "Hydrophobic mixed solvent induced PLGA-based in situ forming systems for smooth long-lasting delivery of Radix Ophiopogonis polysaccharide in rats." RSC Advances 7, no. 9 (2017): 5349–61. http://dx.doi.org/10.1039/c6ra27676h.

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To obtain a sustained in vivo release of Radix Ophiopogonis polysaccharide, hydrophobic solvent-induced in situ forming systems were investigated, including the factors affecting drug release and anti-myocardial ischemic activity of a formulation.

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Chen, Yu-si, Yi-yang Sun, Zi-chen Qin, Sai-ya Zhang, Wen-bo Chen, and Yan-qiang Liu. "Losartan Potassium and Verapamil Hydrochloride Compound Transdermal Drug Delivery System: Formulation and Characterization." International Journal of Molecular Sciences 23, no. 21 (2022): 13051. http://dx.doi.org/10.3390/ijms232113051.

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In this study, we developed a sustained-release transdermal delivery system containing losartan potassium (LP) and verapamil hydrochloride (VPH). LP and VPH have low bioavailability and long half-life. Therefore, the development of an optimum administration mode is necessary to overcome these drawbacks and enhance the antihypertensive effect. A transdermal diffusion meter was used to determine the optimal formulation of LP-VPH transdermal drug delivery systems (TDDS). Based on in vitro results, a sustained-release patch was prepared. Physical characteristics, including quality, stickiness, and

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Mhaske, Nilesh Sureshrao, and S. Sathesh Kumar. "Formulation and Evaluation of Sustained Release Dosage Form of Venlafaxine Hydrochloride for Enhanced Treatment of Neurodisorders." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1495–504. http://dx.doi.org/10.25258/ijddt.14.3.33.

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In the present study, we have designed and developed a sustained-release tablet formulation of Venlafaxine Hydrochloride. The optimized formulation was then subjected to various evaluation parameters. The formulation of venlafaxine hydrochloride sustained release tablets with a dosage of 500 mg included the utilization of several hydrophilic polymers, including jackfruit mucilage, HPMC K4, and PVPK30, as release retardants. This was done to extend the duration of drug release to 12 hours. The formulation features, including pre-compression and post-compression investigations, were conducted in

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Sharafi, Mastaneh, Tyler White, Kelli Fowler, Kevin Ewell, Noe Galvan, and Nima Alamdari. "In Vitro Dissolution Evidence for Sustained and Prolonged Release of Vitamin C in a Phosphatidyl Choline-Enriched Lipid Encapsulation." Current Developments in Nutrition 5, Supplement_2 (2021): 1328. http://dx.doi.org/10.1093/cdn/nzab059_029.

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Abstract Objectives In vitro dissolution tests are valuable first-step tools in the development of bioavailable delivery systems, making it possible to assess the performance of novel technologies in releasing active ingredients through the amount dissolved in a dissolution medium. The objective of this study was to evaluate whether phosphatidyl choline-enriched lipid encapsulation releases the majority of vitamin C as ascorbic acid past the stomach in a standard in vitro dissolution procedure and to assess the release profile. Methods A novel phosphatidyl choline-enriched lipid encapsulation

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Singh, Satbir, Gaikwad Dushyant Dadabhau, and Kehar Singh. "Formulation, Development and Investigation of Matrix Type Sustained Release Tablet of Antiulcer Drug by Using Soluble Polymer as a Drug Release Retarding Agent." International Journal of Membrane Science and Technology 10, no. 4 (2023): 2593–603. http://dx.doi.org/10.15379/ijmst.v10i4.3701.

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The main goals of sustained release drug delivery are to modify the medication's biopharmaceutical, pharmacokinetic, and pharmacodynamic properties in order to lessen adverse effects, increase patient compliance, and treat the illness. The current work set out to create sustained release tablets of nizatidine (220 mg) using a wet granulation process and different concentrations of polymers such as chitosan, Kollidon SR, and HPMC K100M. Pre-formulation characteristics were examined, including medication DSC analysis and FTIR research. We assessed a number of post-compression characteristics, in

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Ryu, Suji, Seungyeop Park, Ha Yeon Lee, Hyungjun Lee, Cheong-Weon Cho, and Jong-Suep Baek. "Biodegradable Nanoparticles-Loaded PLGA Microcapsule for the Enhanced Encapsulation Efficiency and Controlled Release of Hydrophilic Drug." International Journal of Molecular Sciences 22, no. 6 (2021): 2792. http://dx.doi.org/10.3390/ijms22062792.

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Recently, nano- and micro-particulate systems have been widely utilized to deliver pharmaceutical compounds to achieve enhanced therapeutic effects and reduced side effects. Poly (DL-lactide-co-glycolide) (PLGA), as one of the biodegradable polyesters, has been widely used to fabricate particulate systems because of advantages including controlled and sustained release, biodegradability, and biocompatibility. However, PLGA is known for low encapsulation efficiency (%) and insufficient controlled release of water-soluble drugs. It would result in fluctuation in the plasma levels and unexpected

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Pathloth Nandini, M. Sunitha Reddy, and K. Anie vijetha. "Preparation and evaluation of sustained release microspheres for the treatment of diabetic neuropathy." GSC Biological and Pharmaceutical Sciences 28, no. 3 (2024): 197–208. http://dx.doi.org/10.30574/gscbps.2024.28.3.0335.

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This study aimed to prepare and evaluate sustained release microspheres for the treatment of diabetic neuropathy using Various polymers including sodium alginate, ethyl cellulose, HPMC K100, Carbopol 934, and Eudragit L-100-55. Polymers were employed to assess their impact on several crucial parameter’s entrapment efficiency, production yield Particle size analysis, swelling index, in vitro dissolution, and release kinetics. The production yield of microspheres varied depending on the polymer used, with some polymers performing in advanced yields. Entrapment effectiveness was set up to be opti

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Pathloth, Nandini, Sunitha Reddy M., and Anie vijetha K. "Preparation and evaluation of sustained release microspheres for the treatment of diabetic neuropathy." GSC Biological and Pharmaceutical Sciences 28, no. 3 (2024): 197–208. https://doi.org/10.5281/zenodo.14709439.

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This study aimed to prepare and evaluate sustained release microspheres for the treatment of diabetic neuropathy using Various polymers including sodium alginate, ethyl cellulose, HPMC K100, Carbopol 934, and Eudragit L-100-55. Polymers were employed to assess their impact on several crucial parameter’s entrapment efficiency, production yield Particle size analysis, swelling index, in vitro dissolution, and release kinetics. The production yield of microspheres varied depending on the polymer used, with some polymers performing in advanced yields. Entrapment effectiveness was set up to b

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Medarametla, Ramya Teja, K. Venkata Gopaiah, J. N. Suresh Kumar, et al. "Clinical Investigation of Valsartan Sustained-Release Matrix Tablets: Formulation Design and Performance Evaluation." Journal of Pharmaceutical Research International 36, no. 2 (2024): 39–54. http://dx.doi.org/10.9734/jpri/2024/v36i27500.

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The primary objective of this main study is to develop and assess the sustained-release matrix tablets containing Valsartan, an angiotensin II receptor type 1 antagonist. The powder mixtures underwent a thorough examination of pre-compression parameters and observed angle of repose, bulk density, tapped density, and Carr’s index, all of which exhibited satisfactory results. Following compression, the tablets were subjected to post-compression evaluations, including weight variation, thickness, hardness, friability, drug content, in-vitro dissolution, and stability studies. In-vitro dissolution

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Ma, Xingbin, Shuyu Li, Jiajie Qiu, et al. "Development of an Fe3O4 Surface-Grafted Carboxymethyl Chitosan Molecularly Imprinted Polymer for Specific Recognition and Sustained Release of Salidroside." Polymers 15, no. 5 (2023): 1187. http://dx.doi.org/10.3390/polym15051187.

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The choice of carrier material is critical in the study of natural drug release preparations and glycosylated magnetic molecularly imprinted materials. The stiffness and softness of the carrier material affect the efficiency of drug release and the specificity of recognition. The dual adjustable aperture-ligand in molecularly imprinted polymers (MIPs) provides the possibility of individualized design for sustained release studies. In this study, a combination of paramagnetic Fe3O4 and carboxymethyl chitosan (CC) was used to enhance the imprinting effect and improve drug delivery. A combination

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Mohammed, Mushtaq J., and Wedad K. Ali. "Formulation and In-vitro Evaluation of Two Layers Tablet for Dual Release of a Model Drug." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 01 (2023): 45–56. http://dx.doi.org/10.25258/ijddt.13.1.08.

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Objective: Glimepiride is a third-generation sulfonylurea medication that has been used to treat type 2 diabetes (T2D) mellitus. It is class II drug according to the biopharmaceutical classifi cation system (BCS) characterized with its low solubility and high permeability. Due to the drug’s weak water solubility, its bioavailability is restricted by its dissolving rate. This study aimed to develop a bilayer tablet of glimepiride with one layer for immediate release (IR), a dose of 2 mg, a second layer for sustained release (SR), and a 4 mg dose Immediate release layer included solid dispersion

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