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Rozprawy doktorskie na temat „Induces nephrotoxicity”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Paquette, Melanie. "Dietary composition alters gentamicin-induced nephrotoxicity in rats." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30827.

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Macronutrient composition of food was shown to have a potent impact in modulating circadian rhythms of gentamicin toxicity. In the present study, adult female Sprague-Dawley rats fully adapted to isocaloric 20 casein-containing, 20% soy-containing (both semi-purified with 10% safflower oil and 58.55% carbohydrate) or a standard chow diet (non-purified with 18.1% mixed proteins, 4.5% fat and 57.3% carbohydrate) were chronically treated for 10 days with a nephrotoxic dose of gentamicin sulfate (40 mg/kg/day, i.p.) or a saline solution given in the middle of their resting period or in the middle

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2

McWilliam, Stephen. "Novel approaches to aminoglycoside-induced nephrotoxicity in children." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2049479/.

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Background: Aminoglycoside antibiotics are commonly used in paediatric clinical practice, especially for the treatment of neonatal sepsis and pulmonary exacerbations in cystic fibrosis (CF). However, megalin-mediated endocytosis of the aminoglycosides by renal proximal tubule epithelial cells leads to toxicity, and may result in acute kidney injury and chronic kidney disease. Current approaches to identify and prevent toxicity are limited. Several novel biomarkers have shown utility in preclinical studies for the identification of aminoglycoside-induced nephrotoxicity, but clinical data and an

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3

Alghamdi, Saeed Saeed. "The role of cytochrome P4502E1 in solvent-induced nephrotoxicity." Thesis, Queen Mary, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405934.

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MacFarlane, Marion. "The role of cysteine conjugate #beta#-lyase in haloalkene-induced nephrotoxicity." Thesis, University of Surrey, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328376.

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5

Nakamura, Takanori. "Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity." Kyoto University, 2011. http://hdl.handle.net/2433/142112.

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6

Filipski, Kelly K. "Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity." View the abstract Download the full-text PDF version, 2009. http://etd.utmem.edu/ABSTRACTS/2009-022-Filipski-index.htm.

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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2009.<br>Title from title page screen (viewed on August 6, 2009). Research advisor: Alex Sparreboom, Ph.D. Document formatted into pages (ix, 79 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 74-78).

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7

Cockburn, Elinor M. "The relevance of prostanoid metabolism in the development of drug-induced nephrotoxicity." Thesis, University of Aberdeen, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481095.

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The enzymes prostaglandin synthetase (PGS) and lipoxygenase can cooxidise a variety of xenobiotics to reactive intermediates during the metabolism of arachidonic acid (AA). PGS exhibited a gradient of activity within the kidney which was greatest in the papilla and least in the cortex. Rabbit and rat renal microsomes metabolised the model compound, tetramethylphenylenediamine (TMPD), in the presence of AA by pathways which were predominantly PGS and lipoxygenase-dependent, respectively. Therefore, both enxymes may play a role in the development of site-specific nephrotoxicity within the kidney

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8

Tort, Piella A. "Development of novel proximal tubule in vitro models to predict drug-induced nephrotoxicity." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3004444/.

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Drug-induced nephrotoxicity is a dose limiting factor and a common side effect of many drugs such as antibiotics, cancer chemotherapeutics or diagnostic agents and represents 20-25% of all cases of acute kidney injury (AKI). Due to a lack of representative animal models and metabolically competent renal cell lines, only 10.5% of the drug-induced nephrotoxicity cases can be predicted in preclinical studies. Furthermore, it has been recently accepted that mitochondria represent an important target for a broad spectrum of renal toxins. However, the supraphysiological glucose concentrations used i

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9

Wadey, Rebecca. "Characterisation of tools for studying renal mineral ion homeostasis and drug-induced nephrotoxicity." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/71398/.

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The complex interplay between regulatory factors of kidney mineral ion homeostasis are difficult to investigate in vivo. In addition, preclinical drug safety testing is limited by lack of translational tools for screening novel drugs for nephrotoxicity. At Cardiff University, my PhD project aimed to characterise tools to address these needs. At AstraZeneca, the use of tissue biomarkers as tools for assessing kidney injury in retrospective studies where urine biomarker samples are not available, was evaluated. To enable studies of mineral ion homeostasis, an in vitro human primary renal cell mo

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10

Lassila, Markus. "Cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/biola/vk/lassila/.

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11

Gordon, Elaine Mary. "Isolated rat renal proximal tubular cells : a model for the study of drug-induced nephrotoxicity." Thesis, University of Aberdeen, 1990. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU546772.

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Renal proximal tubular cells (&'62 90&'37) were isolated from the rat in high yield by collagenase digestion of renal cortical tissue, followed by isopycnic centrifugation in a Percoll density gradient. The cells were of high viability and their identity verified by morphology and PT specific enzyme activities. Cytochrome P450 and dependent monooxygenase activities were maintained and the rapid decline in reduced glutathione prevented by addition of glycine, glutamate and cystine to the buffers used. These parameters were also maintained in culture (24h). Cytochrome P450-dependent monooxygenas

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12

Bogart, Avery M. "STAT5 Knockout Mice Show Increased Susceptibility to Cisplatin-Induced Acute Kidney Injury." Ohio University Honors Tutorial College / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1524841830342307.

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13

McLaren, John. "Human renal proximal tubular cells, in suspension and primary culture, as in vitro models of drug-induced nephrotoxicity." Thesis, University of Aberdeen, 1992. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU545620.

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The kidney is the target for a wide variety of chemical agents, including heavy metals, haloalkenes, analgesics and antibiotics. The functional and metabolic characteristics of the proximal tubule (PT) predispose it as the primary site for xenobiotic damage. The aim of this study was to isolate and characterise human and rat PT cells in suspension and primary culture for use as defined models to investigate drug-induced PT cell damage in vitro . A second aim was to compare the response of human and rat systems to known nephrotoxins. Human and rat PT cells (90&'37 viable) were isolated from kid

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14

CHIUSOLO, ARIANNA. "Drug-inducted nephrotoxicity: a molecular biology approach to identify early markers of segment-specific proximal tubule injury in rat." Doctoral thesis, Università degli Studi di Verona, 2008. http://hdl.handle.net/11562/337587.

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non disponibile<br>The kidney is especially vulnerable to toxic insult by various drugs and xenobiotics because it receives nearly one quarter of the cardiac output, and transports, metabolizes and concentrates a variety of potentially toxic substances within its parenchyma As a consequence of its primary functions, the kidney is especially vulnerable to toxic insults by various drugs or xenobiotics, and thus nephrotoxicity is one of the major concerns in safety evaluation. Thus, despite the morphological complexity of the kidney, the epithelial cells of proximal tubule stand out as one

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15

Zeeni, Nadine. "Effect of dietary protein level on gentamicin-induced nephrotoxicity in rats and on the circadian rhythms of food ingestion." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98528.

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All aminoglycosides have the potential to cause nephrotoxicity. Previous studies have shown that this toxicity was altered according to the macronutrient composition of dietary regimens offered to female rats. In a first study, adult female Sprague-Dawley rats adapted to a standard chow diet, the standard chow with 20% added casein or with 55% added casein were treated for 10 days with a nephrotoxic dose of gentamicin sulfate (40 mg/kg/day, i.p.) or a saline solution. Food ingestion patterns and gentamicin nephrotoxicity indices were measured. In a second study, rats were fed the same diets, h

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16

Daniele, Cristina [Verfasser], and Norbert [Akademischer Betreuer] Gretz. "Therapeutic potential of human ABCB5+ cells and different conditioned media in a cisplatin-induced nephrotoxicity model / Cristina Daniele ; Betreuer: Norbert Gretz." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1198214503/34.

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17

Ayepola, Omolola Rebecca. "Effects of kolaviron–a Garcinia kola biflavonoid on biochemical and histological parameters in streptozotocin - induced diabetes and diabetic complications (nephrotoxicity and hepatotoxicity) in male Wistar rats." Thesis, Cape Peninsula University of Technology, 2014. http://hdl.handle.net/20.500.11838/1512.

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Thesis submitted in fulfillment of the requirements for the Doctor of Technology: Biomedical Technology In the Faculty of Health and Wellness At the CAPE PENINSULA UNIVERSITY OF TECHNOLOGY 2014<br>Diabetes mellitus (DM) results in severe metabolic imbalances and pathological changes in many tissues. Chronic inflammation and oxidative stress have been implicated in the pathophysiology of diabetes mellitus. Garcinia kola (Family: Guttiferae) is a plant well known for its ample medicinal values. The seed of the plant also known as ‘bitter kola’ due to its bitter taste is used as a masticatory age

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18

Brunner, Nina [Verfasser]. "Metabolomics - New biomarkers for early detection of immunosuppressive-induced nephrotoxicity and chronic rejection after KTX : a translational analysis from animal model to kidney transplant patients / Nina Brunner." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1042940509/34.

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19

Moreira, Maria Margarida Miranda. "Efeitos hepatotóxicos e nefrotóxicos dos antibacterianos." Master's thesis, [s.n.], 2012. http://hdl.handle.net/10284/3566.

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Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>Os antibióticos são medicamentos etiotrópicos sem ação farmacológica sobre as células eucarióticas do Homem, tendo como alvo os locais específicos da célula procariótica. Contudo, apesar desta especificidade de ação, os antibióticos podem exibir efeitos tóxicos nas células humanas, muito embora o risco potencial é baixo tendo em conta o seu elevado número de prescrições. Assim, a nível hepático a lesão induzida pelas penicilinas (ampicilina, benzilpeni

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20

Fuchs, Tobias Christian [Verfasser], Paul [Akademischer Betreuer] Layer, Heribert [Akademischer Betreuer] Warzecha, Philip [Akademischer Betreuer] Hewitt, Bodo [Akademischer Betreuer] Laube, and Kolmar [Akademischer Betreuer] Harald. "Nephrotoxicity biomarkers in vivo and in vitro: Identification and validation of biomarkers for the detection of substance-induced acute and sub-acute renal damage / Tobias Christian Fuchs. Betreuer: Paul Layer ; Heribert Warzecha ; Philip Hewitt ; Bodo Laube ; Kolmar Harald." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2013. http://d-nb.info/1110791658/34.

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Aboulmagd, Khodier Sarah. "Analysis of Lipids in Kidney Tissue Using High Resolution MALDI Mass Spectrometry Imaging." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19443.

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Massenspektrometrisches Imaging (MSI) ist unverzichtbar für die Untersuchung der räumlichen Verteilung von Molekülen in einer Vielzahl von biologischen Proben. Seit seiner Einführung hat sich MALDI zu einer dominierenden Bildgebungsmethode entwickelt, die sich als nützlich erwiesen hat, um die Komplexität von Lipidstrukturen in biologischen Geweben zu bestimmen. Einerseits ist die Rolle von Cisplatin bei der Behandlung von menschlichen malignen Erkrankungen gut etabliert, jedoch ist Nephrotoxizität eine limitierende Nebenwirkung, die Veränderungen des renalen Lipidprofils beinhaltet. Dies füh

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22

Galgamuwa, Arachchige Ramindhu. "An Investigation Into The Prevention Of Cisplatin-Induced Nephrotoxicity By Dichloroacetate." Phd thesis, 2016. http://hdl.handle.net/1885/114502.

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Cisplatin is a highly effective anticancer drug used to treat a range of cancers. However, cisplatin use often leads to nephrotoxicity, which limits its clinical effectiveness. Dichloroacetate (DCA), which has been used to treat lactic acidosis, has emerged over the past decade as a novel anticancer medication. This is primarily due to its ability to reverse the glycolytic phenotype of cancer cells (the Warburg effect). A number of clinical trials assessing its anticancer properties are in progress. It is therefore highly likely that DCA will be used

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23

LIN, CHING-WEI, and 林敬偉. "Mechanism of rosmarimic acid attenuates cisplatin-induced nephrotoxicity." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/mvc23w.

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碩士<br>環球科技大學<br>生物技術研究所<br>106<br>Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactc acid. It is commonly found in species of the Boraginaceae and the subfamily Nepetoideae of the Lamiaceae, mainly, Rosmarinus officinalis L. Rosmarinic acid has a number of biological activities, including antiviral, antibacterial, anti-inflammatory and antioxidant effects. Cisplatin is a potent chemotherapeutic drug for cancer therapy, but it has serious side effect in clinical treatment, particularly nephrotoxicity. The purpose of this study was to evaluate the potential nephroprotecti

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Galgamuwa, Arachchige Ramindhu Galgamuwa. "An investigation into the prevention of cisplatin-induced nephrotoxicity by dichloroacetate." Phd thesis, 2017. http://hdl.handle.net/1885/156075.

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Cisplatin is a highly effective anticancer drug used to treat a range of cancers. However, cisplatin use often leads to nephrotoxicity, which limits its clinical effectiveness. Dichloroacetate (DCA), which has been used to treat lactic acidosis, has emerged over the past decade as a novel anticancer medication. This is primarily due to its ability to reverse the glycolytic phenotype of cancer cells (the Warburg effect). A number of clinical trials assessing its anticancer properties are in progress. It is therefore highly likely that DCA will be used in combination with other well-established

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25

Chiu, Chih-Yin, and 邱芷瑩. "Effects of ginseng and ginsenosides on cisplatin-induced nephrotoxicity in inbred mice." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/65789015477584107917.

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碩士<br>臺北醫學大學<br>藥學研究所<br>95<br>Cisplatin (CDDP) is one of the most commonly used antineoplastic agents for the solid tumor treatment. The major side effect of CDDP is nephrotoxicity. It is dose-related and has become a chief limitation of its clinical use. The purpose of this study was to evaluate the preventive effect of ginseng extract (GE) and its active component, ginsenoside (GS), on cisplatin-induced nephrotoxicity. Six-week-old female BALB/c mice were administered with 5 mg/kg of CDDP intraperitoneally once daily for 5 days. 125, 250, 500 mg/kg of GE or 5 mg/kg of GS Rb1, Rd, Rg1 we

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Huang, Yu-Shen, and 黃昱紳. "Metabolomic studies of metformin’s effects on Pb-induced nephrotoxicity in rats urine." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/aqsdx8.

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HUANG, CHO-CHIA, and 黃卓智. "Nephrotoxicity and Myelosuppression Induced by Cisplatin Administrations in Different Saline Concentrations in Dogs." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/14335270281674366889.

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碩士<br>國立屏東科技大學<br>獸醫學系<br>89<br>In order to compare the cisplatin-induced nephrotoxicity and myelosuppression in different saline concentration vehicles with multiple cisplatin administrations, eighteen apparently healthy-Beagle dogs were used dividing into 3 groups; Two of these groups were infused with 4 doses of cisplatin 70 mg/m2 which were distilled in 0.9% and 3.0% saline at 21 days intervals, respectively. And the control group was infused with 0.9% or 3.0% saline only. Based on results of the serum urea nitrogen, creatinine concentrations and clearance tests of creatinine, the 0.9% s

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Hui-Sheng, Cheng, and 程惠聖. "Effects of green tea , (+)-catechin and sodium salicylate on cisplatin induced nephrotoxicity in inbred mice." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/02197416385660256727.

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碩士<br>臺北醫學大學<br>藥學系<br>94<br>Cisplatin(CDDP) is one of the most commonly used antineoplastic agent for the treatment of solid tumor. The CDDP induced nephrotoxicity is dose-related and cumulative. It is the major dose-limiting toxicity of cisplatin. We used an established CDDP induced nephrotoxicity in inbred mice model to evaluate the effect of green tea extract, (+)-catechin and sodium salicylate. Before administration of CDDP(i.p. 5mg/kg/d on day 1 to day 5), BALB/c mice（6 week, female）were administered orally with green tea extract(GT 75, 150, 300 mg/kg/d), (+)-catechin(CAT 25, 50, 100 mg/

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Wu, Zong-Han, and 吳宗翰. "Preventive effects of Cordyceps cicadae mycelia on cyclosporine A-induced nephrotoxicity and endoplasmic reticulum stress." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/9j2qm9.

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碩士<br>弘光科技大學<br>生物科技研究所<br>103<br>The traditional Chinese medicinal mushroom, Cordyceps cicadae (CC), is one of the species described in Cordyceps. It has been applied in pharmacological effects for the protections of immune modulatory and renal functions. However, it is still unclear whether CC mycelium has protective effects against drug-induced renal function damage and cell apoptosis. This study aimed to investigate the protective effects of CC mycelia against the cyclosporine A (CsA)-induced renal toxicity in vivo. Eight-week-old Sprague-Dawley (SD) rats were divided into six groups, incl

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Huang, Zhi-Yun, and 黃致云. "Effects of ginseng , ginsenoside Rg1 and N-acetylcysteine on cisplatin-induced nephrotoxicity in inbred mice." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/14158514535112029687.

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碩士<br>臺北醫學大學<br>藥學研究所<br>96<br>Cisplatin (CDDP) is one of the most commonly used antineoplastic agents for the solid tumor treatment. The major side effect of CDDP is nephrotoxicity. It is dose-related and has become a chief limitation of its clinical use. The purpose of this study was to evaluate the preventive effects of ginseng extract (GE), its active component, ginsenoside Rg1(GS Rg1) and N-acetylcysteine (NAC) on CDDP-induced nephrotoxicity in bred mice. Six-week-old female BALB/c mice were administered with 5 mg/kg of CDDP intraperitoneally once daily for 5 days. 250 mg/kg of GE or 5 mg

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Wu, Ching-Ann, and 吳晉安. "The Subchronic Feeding Study of Melamine and Cyanuric Acid Mixture-Induced Nephrotoxicity and Recovery in Rats." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/70867279364695455035.

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碩士<br>國立中興大學<br>獸醫病理生物學研究所<br>103<br>Melamine has been used to adulterate animal food and infant formula in order to give false elevated results in the protein content of food. It’s a well-known issue that simultaneous ingestion of melamine and cyanuric acid (MCA) could induce acute renal failure and high mortality in animals or obstructive nephropathy in infants. Many investigators have been devoted to the studies of MCA combined toxicity and the mechanisms of MCA-induced renal injury. In our study, we conducted the subchronic toxicity test of nephrotoxicity of melamine and cyanuric acid comb

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Hsu, Yu-Chia, and 許育嘉. "Polygenic Analytic Approaches in Predicting Cisplatin or Carboplatin-induced Nephrotoxicity in Lung Cancer Patients in Taiwan." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/19044166909744496503.

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Sausen, Peter John. "Cysteine conjugate S-oxidase characterization, purification and investigation into its possible role in cysteine conjugate-induced nephrotoxicity /." 1992. http://catalog.hathitrust.org/api/volumes/oclc/28228349.html.

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Igwebuike, Chinaemere. "The role of proteotoxicity and cross-organelle stress response in drug-induced acute kidney injury." Thesis, 2020. https://hdl.handle.net/2144/41106.

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Nephrotoxicity is a dose-limiting side effect of gentamicin that accounts for a significant portion of clinical acute kidney injury (AKI). The mechanism of gentamicin-induced nephrotoxicity is uncertain and effective therapy for gentamicin-induced renal cell injury is limited by incomplete mechanistic insight. To address this challenge, we hypothesized that RNAi signal pathway screening can identify both a unifying mechanism of gentamicin-induced cell injury and a therapeutic that ameliorates its toxicity. Dual shRNA screens of 5,000 individually barcoded signal pathway genes were performed i

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35

Hui-Ting, Chang, and 張惠婷. "Establishment of the cisplatin induced nephrotoxicity in inbred mice and the effect of bupleuri radix on the nephritis." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/08881746907420692823.

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碩士<br>臺北醫學大學<br>藥學系<br>93<br>Cisplatin (CDDP) is an effective antineoplastic agent in the treatment of various solid tumors. The clinical utility of CDDP is limited because of its nephrotoxicity. We tried to establish CDDP induced nephrotoxicity in inbred mice and investigated the impact of Bupleuri Radix (BR) and pentoxifylline (PTX) on the model. BALB/c mice (6 weeks, female) were intraperitoneally administered with 1.25, 2.5, 5 mg/kg/d of CDDP for 5 days (on day 1 to day 5) to determine the experimental dose. Then, CDDP 5mg/kg/d were administered intraperitoneally to determine the relations

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Shih, Kai-Wen, and 石凱文. "The Correlation between the Polymorphism of Glutathione S-transferases Pi 1(GSTP1) and Cisplatin- or Carboplatin-induced Nephrotoxicity." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/33559762868147472940.

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碩士<br>臺北醫學大學<br>藥學研究所<br>98<br>Background and aims: Cisplatin and carboplatin induced nephrotoxicity is a major dose-limiting factor for platinum-based treatments. Glutathione S-transferase Pi (GSTP) catalyzes the glutathione-conjugation as the first and the key step of nephrotoxin formation from platinum. Four functionally different polymorphisms of human GSTP, differed by A→G at 313 and C→T at 341, have been identified. Carrying A→G variation at 313 may cause higher catalytic efficacy for platinum than the wild-type does. The purpose of this study was to investigate the related risk fact

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Chang, Hui-Yi, and 張惠怡. "Evaluation of Effectiveness of Oral D-methionine on Nephrotoxicity and Anorexia/Cachexia Induced by Chronic Cisplatin Administration Toxicity Model." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/mpvq76.

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碩士<br>中山醫學大學<br>營養學研究所<br>104<br>Cisplatin is a widely used chemotherapeutic agent for the treatment of solid tumors. Its clinical use is limited due to severe side effects such as nephrotoxicity and anorexia/cachexia. Many sulfur containing compounds have been reported to protect against cisplatin-induced cytotoxicity. D-methionine, dextro-isomer of L-methionine, is a sulfur containing amino acid and can act as potent antioxidants. In this study, we investigate the effects of oral D-methionine on cisplatin-induced nephrotoxicity and anorexia/cachexia. Male Wistar rats were divided into three

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Chen, An-Zhi, та 陳峖覟. "Effects of glycyrrhizic acid and 18β-glycyrrhetinic acid on LPS-induced acute lung injury and their protective roles on Cisplatin-induced nephrotoxicity in BALB/c mice". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/hfk585.

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碩士<br>國立中興大學<br>食品暨應用生物科技學系所<br>101<br>Abstract Licorice (Glycyrrhiza) species are perennial herbaceous Leguminosae plant, as traditional herbal medicine, and widely distributed in Inner Mongolia, Xinjiang and the Northeast of China. The pharmacological activities sush as antimicrobial, antioxidative, antiinflammatory, respiratory protective and renoprotective effects of licorice are mainly represented by main triterpenoid saponins, glycyrrhizic acid (GA) and its metabolite 18β-glycyrrhetinic acid (18βGA). Two kinds of animal model were used to evaluate the protective effects of lipopolysacc

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Kuo, Yi-Chun, and 郭怡君. "Effects of ginseng and sodium salicylate on cisplatin-induced nephrotoxicity in inbred mice and quantitative analysis of ginsenosides in ginseng extract." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/57222660145093579883.

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碩士<br>臺北醫學大學<br>藥學研究所<br>97<br>Cisplatin (cis-diamminedichloroplatinum (Ⅱ), CDDP) is one of the most commonly used antineoplastic agents in the treatment of various solid tumors. However, the full clinical utility of CDDP is limited because of its dose-related nephrotoxic side effects. The purpose of this study was to evaluate the preventive effects of ginseng extract (GE) and sodium salicylate (S) on CDDP-induced nephrotoxicity in bred mice. Besides, this study also did quantitative analysis by high performance liquid chromatography (HPLC) to comfirm the quantity of ginsenosides in GE. I

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Tsai, Mu-Cheng, and 蔡牧承. "Effects of ginsenoside Rg1 and N-acetylcysteine on methylglyoxal and D-lactate in cisplatin-induced nephrotoxicity kidney tissues in inbred mice." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/p97r7w.

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碩士<br>臺北醫學大學<br>藥學系(碩博士班)<br>102<br>In this study, we investigated the effect of ginsenoside Rg1 (GS Rg1) and N-acetylcysteine (NAC) on the concentration of methylglyoxal (MG) and D-lactate and evaluated the MG and D-lactate as indicators in cisplatin-induced nephrotoxicity kidney tissues. We divided 30 six-week-old female BALB/c mice into five groups. Then, we used cisplatin (5 mg/kg/day) intraperitoneally to induce nephrotoxicity for 5 day except for the Normal group at the 6th day. Besides, the mice were orally administered GS Rg1 5 mg/kg/day, NAC 450 mg/kg/day and GS Rg1+NAC for 10 days, r

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Shamsuyarova, Anastasia. "Overexpression of catalase prevents gentamicin – induced apoptosis of renal proximal tubular cells in transgenic mice." Thèse, 2015. http://hdl.handle.net/1866/12058.

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Fuchs, Tobias Christian. "Nephrotoxicity biomarkers in vivo and in vitro: Identification and validation of biomarkers for the detection of substance-induced acute and sub-acute renal damage." Phd thesis, 2013. https://tuprints.ulb.tu-darmstadt.de/3384/1/PhD_Thesis_Tobias_C._Fuchs_TUD.pdf.

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The major aims of this work included the evaluation of urinary protein markers, transcriptional analysis of the underlying mechanism of Vancomycin-induced nephrotoxicity based on gene expression analysis, the evaluation and generation of reliable transcriptional biomarkers. In addition, the utility of an in vitro test system to produce in vivo like responses to nephrotoxin treatment was tested. Therefore, several questions, important for the further enhancement of preclinical safety assessment as well as the understanding of the underlying mechanism of drug-induced nephrotoxicity, were address

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Διαμαντόπουλος, Αθανάσιος. "Μελέτη της προφυλακτικής δράσης της παρστατίνης έναντι της νεφροτοξικότητας των ιωδιούχων σκιαγραφικών μέσων κατά τη διάρκεια εξετάσεων με ψηφιακή αφαιρετική αγγειογραφία". Thesis, 2013. http://hdl.handle.net/10889/6306.

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Εισαγωγή: Τα ιωδιούχα σκιαγραφικά μέσα (ΣΜ) σήμερα χρησιμοποιούνται ευρέως τόσο για διαγνωστικούς λόγους όσο και κατά τη διάρκεια επεμβατικών πράξεων στην Επεμβατική Ακτινολογία ή/και την καρδιολογία. Δυστυχώς, η χρήση τους δεν στερείται επιπλοκών με την νεφροτοξικότητα (Νεφροτοξικότητα οφειλόμενη στα ΣΜ - ΝΣΜ) να είναι μία από τις πιο σοβαρές συνέπειες. Παρά το γεγονός ότι πολλές στρατηγικές με σκοπό τόσο την πρόληψη όσο και την θεραπεία έχουν προταθεί και δοκιμαστεί ευρέως τα τελευταία χρόνια στη μάχη κατά της ΝΣΜ, καμία δεν έχει καταφέρει να δείξει ισχυρά αξιόπιστα αποτελέσματα. Η Παρστα

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Chen, Pei-Chun, and 陳佩君. "Antrodan, a glycoprotein isolated from Antrodia cinnamomea mycelia, in combination with cisplatin inhibits tumor metastasis and protects against cisplatin-induced nephrotoxicity in C57BL/6 mice xenografted with Lewis lung carcinoma." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/63308341857956854979.

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碩士<br>國立中興大學<br>食品暨應用生物科技學系所<br>103<br>Antrodia cinnamomea is a species known to be a treasured medicinal mushroom in Taiwan. Several studies have indicated that Antrodan, the glycoprotein from Antrodia cinnamomea mycelia, exhibits anti-inflammation and anti-oxidative actions. In addition, Antrodan has been shown to inhibit cancer metastasis in Lewis lung carcinoma (LLC) through direct action and immunomodulation. However, it is still unclear whether Antrodan has anti-metastatic effects in vivo. This study aimed to investigate the anti-metastatic effects of Antrodan and Antrodan in combination

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