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Rozprawy doktorskie na temat „Influx de calcium”

Autor: Grafiati
Data publikacji: 2 listopada 2024
Data aktualizacji: 31 lipca 2025

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1

Wang, Fang. "DOES CALCIUM INFLUX THROUGH T-TYPE CALCIUM CHANNEL INDUCE CARDIOMYOCYTE PROLIFERATION?" Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/214814.

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Physiology<br>Ph.D.<br>Cardiovascular disease remains the number one cause or mortally in the western world. Heart failure is the most rapidly growing cardiovascular disease (Hobbs, 2004; Levy, et al., 2002). Heart failure, by definition, is progressive deteriorating function of the heart due to progressive cardiac myocytes loss. Though after decades of endeavor of searching the pathophysiology and treatments for heart failure, it remains highly lethal. Therefore, it is vital to find novel therapies to help treat such chronic disease. Replace the lost cardiomyocyte with new ones could restore
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Yang, Meng. "Calcium influx, celluar signaling and the biology of candida albicans." Thesis, University of Aberdeen, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499748.

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<i>FIG1 </i>is a gene that encodes a transmembrane protein involved in calcium influx a process that is important for stress responses in pathogens fungi such as <i>Candida albicans.</i> A <i>Cafig1 </i>null mutant took up less calcium ions in mating than control strains confirming its role in Ca<sup>2+</sup> uptake.  Furthermore, <i>C. albicans </i>strains with deletions of <i>FIG1 </i>in other calcium channel mutant backgrounds displayed distinctive phenotypes under vegetative growth conditions, which suggested that Fig1 may be a regulator of other calcium influx systems. Using GFP and <i>La
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Pejović, Vojislav. "Glutamate induced potentiation of calcium influx in primary hippocampal culture neurons." [S.l.] : [s.n.], 2001. http://ArchiMeD.uni-mainz.de/pub/2001/0027/diss.pdf.

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McVicker, Clare Geldard. "Calcium influx mechanisms during mediator-induced responses in human airway smooth muscle." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404814.

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Makarewich, Catherine Anne. "MICRODOMAIN BASED CALCIUM INFLUX PATHWAYS THAT REGULATE PATHOLOGICAL CARDIAC HYPERTROPHY AND CONTRACTILITY." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/266828.

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Molecular and Cellular Physiology<br>Ph.D.<br>Pathological cardiac stressors, including persistent hypertension or damage from ischemic heart disease, induce a chronic demand for enhanced contractile performance of the heart. The cytosolic calcium (Ca2+) transient that regulates myocyte contraction must be persistently increased in disease states in order to maintain cardiac output to sustain the metabolic requirements of the body. Associated with this enhanced intracellular Ca2+ ([Ca2+]i) state is pathological cardiac myocyte hypertrophy, which results in large part from the activation of Ca2
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Kortekaas, Phaedra. "Development and function of calcium influx in pyramidal neurons of the hippocampal CA1 region." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/55584.

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DeJong, Danica. "Calcium Alleviates Symptoms in Hyperkalemic Periodic Paralysis by Reducing the Abnormal Sodium Influx." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23487.

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Hyperkalemic periodic paralysis, HyperKPP, is an inherited progressive disorder of the muscles caused by mutations in the voltage gated sodium channel (NaV1.4). The objectives of this thesis were to develop a technique for measurement symptoms in vivo using electromyography (EMG) and to determine the mechanism by which Ca2+ alleviates HyperKPP symptoms, since this is unknown. Increasing extracellular [Ca2+] ([Ca2+]e) from 1.3 to 4 mM did not result in any increases in45Ca2+ influx suggesting no increase in intracellular [Ca2+] ([Ca2+]i) acting on an intracellular signaling pathway or on an ion
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8

Hoffman, Nicholas. "Mitochondrial Calcium Influx is Determined by Multiple Protein Components Including SLC25A23 and MICU1." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/287159.

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Biochemistry<br>Ph.D.<br>Ca2+ control mechanisms employed by the cell at the plasma membrane include receptor operated, voltage-sensitive, and store operated channels for Ca2+ import. Upon entry into the cytosol, Ca2+ is sequestered by Ca2+ binding proteins, the endoplasmic reticulum (ER), or by mitochondria. The largest Ca2+ store in the cell is the ER where Ca2+ levels approach millimolar levels. The ER regulates cytosolic Ca2+ homeostasis by using Ca2+ binding proteins, the SERCA pump, second messenger Ca2+ release upon IP3 receptor activation, and Ca2+-induced Ca2+ release by ryanodine rec
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9

Torihashi, Shigeko, Toyoshi Fujimoto, Claudia Trost, Shinsuke Nakayama, and 茂子 鳥橋. "Calcium oscillation linked to pacemaking of interstitial cells of Cajal;Requirement of calcium influx and localisation of TRP4 in caveolae." The American Society for Biochemistry and Molecular Biology, 2002. http://hdl.handle.net/2237/7447.

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Obolensky, Anna. "Pharmacological modulation of calcium influx in freshly isolated rat lymphocytes and lymphoma cell lines." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249555.

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11

Perera, Naomi Tessa. "ZnT‐1 expression in the preimplantation mouse embryo and its effect on calcium influx." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/13519.

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ZnT-1 expression in the pre-implantation mouse embryo and its effect on calcium influx Pre-implantation embryos develop into 9 stages over the first 5 days post-fertilisation. Calcium influx from the external environment via calcium channels, including the L-type and T-type calcium channels, is critical for embryonic gene activation and cell proliferation. In cardiomyocytes these channels are regulated by the ubiquitously expressed zinc-transporter protein ZnT-1. When plasma membrane bound, ZnT-1 facilitates zinc-efflux. Free cellular zinc regulates ZnT-1 expression, with an increase in zinc
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12

Spasevska, Ivana. "The role of EGR-1 and calcium influx in the antitumor activity of anti-CD20 monoclonal antibodies." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1304/document.

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Les anticorps monoclonaux (AcM) anti-CD20 sont essentiels pour le traitement du lymphome non hodgkinien et de la leucémie lymphoïde chronique (LLC). Les AcM agissent soit en activant directement la signalisation apoptotique dans les cellules cibles, soit via le système immunitaire. Dans une étude préclinique, nous avons montré que le traitement avec AcM anti-CD20, rituximab et GA101, induit l'expression de la protéine early growth response 1 (EGR-1) (Dalle et al., 2011). EGR-1 est un facteur de transcription régulé par le calcium (Ca2+) et CD20 est impliqué dans la régulation du flux calcique
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13

Cifelli, Carlo. "Impairment of force development in K(ATP) channel deficient skeletal muscle involves calcium ion influx through L-type calcium ion channels." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27342.

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ATP-sensitive potassium (KATP) channels link membrane excitability to metabolism. They are regulated by intracellular nucleotides and other factors, and have been shown to play a role in development of skeletal muscle force, but controversy surrounds their role during fatigue. The aim of this research project was to determine the role of KATP channel under conditions that allow for better assessment of changes in force during fatigue, by virtue of using a smaller whole muscle model less subject to anoxia. Thus, the first objective was to determine the effect of the loss of KATP channel activit
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14

Shailes, Sarah. "Regulation of calcium influx and reactive oxygen species production during infection of legumes by rhizobia." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/48752/.

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Nod factor (NF) can induce two separate calcium responses in legume root hairs. Nuclear-associated calcium spiking is central to the symbiosis signalling (Sym) pathway, which is necessary for the activation of genes required for nodule formation and bacterial infection. In addition NF activates a tip-focused calcium influx, which is less-well studied but is thought to be involved in bacterial infection. NF also activates ROS transient production at the tip of root hair cells. In this thesis I used fluorescent probes (Ca2+-sensitive Cameleons YC2.1 and YC3.6 and the ROS-sensitive CM-H2DCFDA dye
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15

Khawaja, Rabia Raheel. "Role of calcium influx through glutamate receptors in white matter brain injury and oligodendrocyte regeneration." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/583654.

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Biomedical Sciences<br>Ph.D.<br>Calcium-influx through ionotropic glutamate receptors expressed on non-excitable cells, such as CNS glia, may regulate important cell events via intracellular signaling mechanisms. Oligodendrocytes and oligodendrocyte progenitors (OPCs), two glial populations supporting CNS myelination and myelin repair, express AMPA and NMDA receptors. Although calcium-influx through these receptors is thought to cause glutamate excitotoxicity to oligodendrocytes in CNS injuries, more recent studies suggest that AMPA or NMDA receptor-mediated synaptic transmission between neuro
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16

Egunlusi, Ayodeji Olatunde. "Novel norbornane derivatives as potential neuroprotective agents." University of Western Cape, 2020. http://hdl.handle.net/11394/7339.

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Philosophiae Doctor - PhD<br>Neurodegenerative disorders are characterised by progressive loss of the brain’s physiological functions as a result of gradual degeneration of neurons in the central nervous system. Even though they are classified as diseases of the elderly, occurrence earlier in life is possible, but that would suggest the influence of genetic and/or environmental factors. Due to the continuous rise in modernisation and industrialisation over the years, there has been an increase in incidence and prevalence of neurodegenerative disorders. With the advances in technology and
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17

Bretherton, Nicola. "The effect of cis-5,8,11,14,17-eicosapentaenoic acid upon the contractile mechanisms linked to calcium influx and the mobilisation of intracellular calcium in aortic smooth muscle." Thesis, Aston University, 1998. http://publications.aston.ac.uk/10988/.

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Epidemiological studies previously identified cis-5,8,11,14,17-eicosapentaenoic acid (EPA) as the biologically active component of fish oil of benefit to the cardiovascular system. Although clinical investigations demonstrated its usefulness in surgical procedures, its mechanism of action still remained unclear. It was shown in this thesis, that EPA partially blocked the contraction of aortic smooth muscle cells to the vasoactive agents KCl and noradrenaline. The latter effect was likely caused by reducing calcium influx through receptor-operated channels, supporting a recent suggestion by Asa
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18

Ricker, Ellen M. "The inhibitory effects of opioids on voltage-gated calcium influx in neonatal rat carotid body type I cells." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1424262410.

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De, Paula Daisy Maria Bentes [UNIFESP]. "Estudo do mecanismo molecular de transfecção mediada por ultrassom." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/9564.

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Made available in DSpace on 2015-07-22T20:50:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-11-24<br>O ultrassom (US) vem sendo amplamente utilizado para melhorar a eficiência de transfecção de vetores não-virais. No entanto, o mecanismo pelo qual o US promove a entrega de DNA nas células ainda é pouco entendido. Este fenômeno é normalmente atribuído a sonoporação. Porém, com base em experimentos anteriores realizados em nosso laboratório, suspeitamos que outro mecanismo esteja envolvido no processo de captação de DNA. Para estudar o mecanismo de entrega, um vetor plasmideal expr
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20

Mulligan, Sean Joseph. "Characterization of mitral cell presynaptic calcium influx and synaptic transmission in an in vitro, en bloc frog forebrain preparation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ37597.pdf.

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21

Yang, Heng. "TRPM4, a non selective cation-permeable channel regulates Foxp3+ regulatory T cells suppressive function and survival trough modulating calcium influx." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA114840.

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TRPM4, un canal cationique non-sélective activé par le Ca2+ intracellulaire, est un acteur moléculaire important impliqué de la régulation du signal calcique et l’activation des lymphocytes T conventionnels mais son rôle dans la fonction des lymphocytes T régulateurs (Tregs Foxp3+) reste inconnu. Dans un modèle de souris transgéniques dans lequel le gène Trpm4 a été sélectivement invalidé dans la population des Tregs Foxp3+ (souris Foxp3(YFP)Cre+Trpm4flox/flox), nous avons démontré dans différents modèles in vivo d’inflammation aiguë et chronique que TRPM4 contrôle la fonction suppressive et l
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22

Zhang, Zehua [Verfasser], Matthias [Akademischer Betreuer] Engel, and Peter [Gutachter] Reeh. "The modulatory effects of STW 5 and Menthacarin on cellular calcium ion influx in vitro / Zehua Zhang ; Gutachter: Peter Reeh ; Betreuer: Matthias Engel." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1224101979/34.

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Zanatta, Leila. "Mechanism of action of 1(alfa),25-dihydroxyvitamin D3 on cytochrome P-450 aromatase, calcium influx and gamma glutamyl transpeptidase in rat testis." Florianópolis, SC, 2011. http://repositorio.ufsc.br/xmlui/handle/123456789/95390.

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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2011<br>Made available in DSpace on 2012-10-26T00:59:43Z (GMT). No. of bitstreams: 0
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24

Daziano, Guillaume. "Rôle du propeptide de la sortiline et de ses dérivés dans les mécanismes de survie de la cellule bêta pancréatique." Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://www.theses.fr/2021COAZ6025.

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En 2019, la Fédération Internationale du Diabète a révélé que près de 500 millions de personnes étaient atteintes de diabète dans le monde. On estime que cette incidence atteindra les 700 millions de personnes en 2045. Outre, l’aspect financier de la prise en charge, le diabète est un véritable enjeu de santé publique. En effet, l’environnement hyperglycémique délétère associé au diabète est à l’origine de graves complications pouvant altérer le fonctionnement de nombreux organes tels que le cœur, le cerveau ou encore le rein. La résistance à l’insuline associée à la détérioration de la sécrét
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Vachel, Laura. "Étude de l'influx calcique des cellules épithéliales bronchiques mucoviscidosiques : implication des canaux TRP." Thesis, Poitiers, 2014. http://www.theses.fr/2014POIT2303/document.

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Les canaux TRP (Transient Receptor Potential) sont des acteurs clés de l'homéostasie calcique. Plusieurs de ces canaux interviennent dans l'influx calcique des cellules épithéliales bronchiques, notamment TRPC6, qui est impliqué dans un couplage fonctionnel avec le canal Cystic Fibrosis Transmembrane conductance Regulator (CFTR). Les mutations du CFTR (F508del et G551D) sont à l'origine de la mucoviscidose (Cystic Fibrosis (CF)), qui aboutit à l'augmentation de l'influx calcique dans les cellules CF. L'objectif de ce travail a été d'étudier l'implication des canaux TRP dans la dérégulation de
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Qu, Mengdi. "Molecular mechanism underlying CaMK1D-dependent function in AgRP neurons." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ029.

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La perturbation des mécanismes de réponse au stress chez les organismes peut entraîner une dysfonction cellulaire et des maladies telles que le syndrome métabolique. L'équilibre énergétique est principalement régulé par le système nerveux central (SNC), qui intègre des signaux hormonaux, neuronaux et alimentaires provenant de divers tissus. Une dysfonction de ce système est liée à l'obésité et au syndrome métabolique, qui sont tous deux des précurseurs du diabète de type 2 (T2D). Notre laboratoire a découvert que la protéine kinase ID dépendante du calcium/calmoduline (CaMK1D), un gène associé
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27

Sabourin, Jessica. "Influx cationique dépendant des canaux TRPCs dans les cellules musculaires squelettiques : régulation par le complexe dystrophine/alpha1-syntrophine et par la voie PLC : implication dans la dystrophie musculaire de Duchenne." Poitiers, 2009. http://theses.edel.univ-poitiers.fr/theses/2009/Sabourin-Jessica/2009-Sabourin-Jessica-These.pdf.

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La dystrophine est une protéine du cytosquelette normalement exprimée sous la membrane des cellules musculaires squelettiques. L'absence de cette protéine dans la Dystrophie Musculaire de Duchenne (DMD) entraîne la nécrose des fibres musculaires, résultant entre autres d'une dérégulation des mouvements calciques à travers le sarcolemme et par conséquent d'une augmentation du calcium libre dans le myoplasme. A l'heure actuelle, le lien entre l'absence de dystrophine et l'altération calcique n'est toujours pas établi et l'objectif de ce travail a été de le mettre en évidence. Les expériences ont
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28

Rossato, Mateus Fortes. "Eriodictiol: um flavonóide antagonista do receptor trpv1 com atividade antioxidante." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/11134.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The transient receptor potential vanilloid 1 (TRPV1) is a calcium permeable channel responsible for the transduction and modulation of acute and chronic pain signaling, being a potential target for treatment of different pain disorders. In spite of that, AMG517, a TRPV1 antagonist, presents several clinical limitations, such as the development of severe hypertermia. The aim of this study was to investigate the possible interaction of the flavonoid eriodictyol with the TRPV1 receptor and its putative antinociceptive and hypertherm
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Shoji, Emi. "Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells." Kyoto University, 2015. http://hdl.handle.net/2433/200495.

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Sharma, Rajan. "Synthesis & biological evaluation of neuroprotective molecules with polycyclic scaffolds." University of the Western Cape, 2017. http://hdl.handle.net/11394/6228.

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Doctor Pharmaceuticae - Dpharm<br>Among neurological disorders, many of the most devastating disorders are neurodegenerative. Modern research associates excitotoxicity to a variety of neuropathological conditions, suggesting that the neurodegenerative diseases with distinct etiologies may have excitotoxicity as a common pathway. Excitotoxicity occurs through over-stimulation of receptors for excitatory neurotransmitters like the N-methyl-D-aspartate (NMDA) receptors. Due to the relevance of NMDA receptors and excitotoxic processes, the antagonism or modulation of NMDA receptors is used as a th
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Djillani, Alaeddine. "Caractérisation des canaux calciques dans les polynucléaires neutrophiles : rôle dans la phagocytose et la production des radicaux libres oxygénés." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-01069097.

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Les polynucléaires neutrophiles représentent 50-70% des leucocytes sanguins et possèdent un rôle majeur dans la défense de l'organisme contre les pathogènes. Le Ca2+ est un second messager qui joue un rôle primordial dans le chimiotactisme, la phagocytose, la dégranulation et la production de formes réactives de l'oxygène (FRO) afin de neutraliser l'agent pathogène. Dans ces cellules, l'influx calcique de type SOCE est essentiel pour l'homéostasie calcique. Il est peu étudié en raison du manque d'outils pharmacologiques spécifiques d'où l'importance dans un premier temps de chercher de nouvell
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Ampem, Prince Tuffour. "The Transient Receptor Potential Canonical 3 (TRPC3) Channel: Novel Role in Endothelial Cell Apoptosis and its Impact on Atherosclerosis." University of Toledo Health Science Campus / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=mco1493230041479167.

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Langford, Peter R. "c-Met Initiates Epithelial Scattering through Transient Calcium Influxes and NFAT-Dependent Gene Transcription." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/3186.

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Hepatocyte growth factor (HGF) signaling drives epithelial cells to scatter by breaking cell-cell adhesions and migrating as solitary cells, a process that parallels epithelial-mesenchymal transition. HGF binds and activates the c-Met receptor tyrosine kinase, but downstream signaling required for scattering remains poorly defined. This study addresses this shortcoming in a number of ways.A high-throughput in vitro drug screen was employed to identify proteins necessary in this HGF-induced signaling. Cells were tested for reactivity to HGF stimulation in a Boyden chamber assay. This tactic yie
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Barbar, Élie. "Effets de la 4-aminopyridine sur le lymphocyte T Jurkat influx calcique, induction de l'apoptose et perméation d'ions." Thèse, Université de Sherbrooke, 2004. http://savoirs.usherbrooke.ca/handle/11143/4245.

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La 4-aminopyridine (4-AP) est utilisée dans le traitement expérimental de plusieurs maladies du système nerveux. Son action bénéfique est médiée via le blocage de canaux potassiques, ce qui améliore la transmission de l'influx nerveux ainsi que la force motrice musculaire. Outre sa propriété de bloquer les canaux K + , la 4-AP possède plusieurs autres effets cellulaires qui ne sont pas complètement caractérisés. Par exemple, elle alcalinise le milieu intracellulaire, induit une réponse calcique et peut causer la mort cellulaire. Dans une première étude, nous avons utilisé la lignée de lymphocy
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Waiczies, Sonia. "Modulation of human antigen-specific T-cell response therapeutic implications for multiple sclerosis /." Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969681844.

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Galdino, Jos? Nildo. "Influ?ncia do teor e granulometria da calcita e da temperatura de sinteriza??o no desenvolvimento de massas cer?micas para revestimento poroso(BIII)." Universidade Federal do Rio Grande do Norte, 2010. http://repositorio.ufrn.br:8080/jspui/handle/123456789/15903.

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Made available in DSpace on 2014-12-17T15:01:51Z (GMT). No. of bitstreams: 1 JoseNG_TESE.pdf: 4686361 bytes, checksum: ece8f07ff848703fdc4412907a924e10 (MD5) Previous issue date: 2010-04-08<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>This work aims at studying the influence of the concentration of calcite, its grain size and sintering temperature to obtain porous coating formulations that meet the design specifications. The experiments involved the physical-chemical and mineralogical caracterization of the raw materials, and mechanical tests on specimens dried and sinte
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Oliveira, Gislaine Alves de. "A ação espasmolítica do óleo essencial de Lippia microphylla Cham. e de seus constituintes majoritários envolve o bloqueio do influxo de cálcio em íleo de cobaia." Universidade Federal da Paraí­ba, 2014. http://tede.biblioteca.ufpb.br:8080/handle/tede/6824.

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Made available in DSpace on 2015-05-14T13:00:03Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2254187 bytes, checksum: afd8368a3a0714175ddde1bb708cc9f9 (MD5) Previous issue date: 2014-02-18<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>The essential oil extracted from aerial parts of Lippia microphylla Cham. (Verbenaceae) (LM-OE) presents as major compounds thymol and carvacrol. The aim of this study was to investigate and to characterize oil LM-OE spasmolytic effect on guinea pig ileum, as well to verify if this effect is due its major compunds, thymol and car
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Ferraz, Sandro Aparecido. "Estimativa do influxo de calcio por meio de canais tipo L em miocitos cardiacos isolados de ratos neonatos e adultos." [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/260336.

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Orientadores: Jose Wilson Magalhães Bassani, Rosana Almada Bassani<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Eletrica e de Computação<br>Made available in DSpace on 2018-08-03T14:47:38Z (GMT). No. of bitstreams: 1 Ferraz_SandroAparecido_D.pdf: 1448610 bytes, checksum: a9c45fc4793f0fcc51ece98aa6fff77c (MD5) Previous issue date: 2003<br>Doutorado
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Leite, Jocelmo Cassio de Araujo. "Desenvolvimento embrionário de Ouriços-do-mar da espécie Echinometra lucunter (Linnaeus, 1758) envolve influxo de cálcio através dos canais de cálcio sensíveis à voltagem." Universidade Federal da Paraí­ba, 2011. http://tede.biblioteca.ufpb.br:8080/handle/tede/6871.

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Made available in DSpace on 2015-05-14T13:00:18Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 4056353 bytes, checksum: ec317eee623ca7f537cb2773d854de24 (MD5) Previous issue date: 2011-02-25<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Ca2+ is an intracellular messenger that controls a wide range of physiological functions through changes in its cytosolic concentration ([Ca2+]c). The increase in [Ca2+]c is derived of mobilization from intracellular stores or influx through channels, especially voltage-gated (Cav), present on cell surface. According to scientifi
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Zanotto, Camila Ziliotto. "Papel da O-glicosilação com N-acetil-glucosamina (O-GlcNAc) no influxo e recaptação de cálcio pelo retículo sarcoplasmático em aorta de ratos: análise funcional." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/17/17133/tde-09092013-133940/.

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A O-glicosilação com N-acetil-glucosamina (O-GlcNAc) é uma modificação pós-translacional altamente dinâmica que modula diversas vias de sinalização. O processo de O-GlcNAc é controlado por duas enzimas: a enzima OGT é responsável por catalisar a adição de N-acetil-glucosamina no grupo hidroxila dos resíduos de serina e treonina, enquanto a OGA catalisa a remoção de O-GlcNAc das proteínas modificadas. Proteínas com importante papel na função vascular são alvo de O-GlcNAc e o aumento da expressão de proteínas modificadas por O-GlcNAc promove aumento da reatividade vascular para estímulos contrát
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Menasché, Philippe. "Étude expérimentale des solutions cardioplégiques : applications à la chirurgie cardiaque." Paris 11, 1987. http://www.theses.fr/1987PA112086.

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L'objectif de ce travail a été d'améliorer la protection myocardique au cours des épisodes d'ischémie globale inhérents aux interventions chirurgicales cardiaques. Notre modèle expérimental a été le cœur isolé perfusé de rat, soit travaillant soit isovolumique. Les résultats ont été évalués sur les critères hémodynamiques habituels complétés par les critères biochimiques fournis par RMN du phosphore 31. Dans un premier temps, nous avons cherché à mettre au point une solution cardioplégique ayant pour but principal de limiter la surcharge calcique intracellulaire. A cet effet ont été définis un
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Rosso, Angela. "Estudo do envolvimento iônico e de proteínas cinases no mecanismo de ação da 1-a,25(OH)2 vitamina D3, no influxo de cálcio em células de Sertoli e em testículos de ratos." reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/94538.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Bioquímica, Florianópolis, 2010<br>Made available in DSpace on 2012-10-25T11:39:52Z (GMT). No. of bitstreams: 1 276693.pdf: 1653605 bytes, checksum: 92e108206ef61f401325ee0b2476c79f (MD5)<br>Tendo em mente que a 1,25D3, produto final do metabolismo da vitamina D3 é essencial para a integridade do sistema reprodutor masculino, e que, a homeostase do Ca+2 desempenha papel chave em muitos processos envolvidos na espermatogênese, avaliamos o efeito em nível membranar da 1,25
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Silva, Neto Gilson da. "Estudo de Mat?rias-Primas do Rio Grande do Norte para Uso em Revestimento Poroso: Influ?ncia do teor de dolomita e temperatura de calcina??o nas propriedades f?sico-mec?nicas." Universidade Federal do Rio Grande do Norte, 2007. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12875.

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Made available in DSpace on 2014-12-17T14:07:23Z (GMT). No. of bitstreams: 1 GilsonSN.pdf: 6365807 bytes, checksum: a479a13345717293c658748ef49aab97 (MD5) Previous issue date: 2007-07-04<br>The state of Rio Grande do Norte presents a great potentiality for the production of ceramic tiles because of having natural raw material in quantity and quality making its economical exploration possible, beyond the great energetic differential of the state, the natural g?s. This works aims to study the influence of the dolomite and granulometry concentration and calcinations temperature in the obtaining
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Kuo-Jung, Lo, and 羅國榮. "Store depletion-induced calcium influx in." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/35075435790662562236.

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碩士<br>國防醫學院<br>生物化學研究所<br>86<br>Using the fluorescent Ca2+ indicator fura-2, we found that, in cultured rat cerebellar astrocytes, a sustained increase of cytosolic Ca2+ concentration ([Ca2+]i) was induced by ATP or angiotensin II (AGII) following a transient increase of [Ca2+]i in the presence of extracellular Ca2+, while it was not seen in the absence of extracellular Ca2+, [Ca2+]i being declined to the basal level. Similarly, a slow and sustained [Ca2+]i increase, or a slow but not sustained [Ca2+]i increase was observed after intracellular Ca2+ pump was inhibited by thapsigargin (TG) in t
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"Regulation of TRPC3-mediated Ca2+ influx and flow-induced Ca2+ influx." Thesis, 2006. http://library.cuhk.edu.hk/record=b6074196.

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Kwan Hiu Yee.<br>"June 2006."<br>2+ in the title is superscript.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2006.<br>Includes bibliographical references (p. 131-150).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstracts in English and Chinese.
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E-Fong, Kao, and 高一峰. "Capacitative Calcium Influx in C6 Glioma Cells." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/01870397043096944408.

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Yoo, Andrew. "Role of calcium influx in process extension of oligodendrocytes." Thesis, 1998. http://hdl.handle.net/2429/8375.

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The effects of phorbol ester, which activates protein kinase C (PKC), and free cytosolic Ca²+ were studied on their role in process extension in cultured murine oligodendrocytes. Previous studies have shown that PKC activation by phorbol esters greatly enhances process formation in cultured oligodendrocytes (OLG), an important step for myelination. Because of the possible involvement of PKC and Ca²+ in process extension in OLGs, we studied the effect of PKC activation on changes in intracellular free Ca²+ concentration ([Ca²+]i). We found that PKC activation by phorbol esters induced a s
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Shan, Ke, and 單可. "Mitochondrial ROS release triggered by calcium influx activates autophagy." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/uuc72e.

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碩士<br>國立臺灣大學<br>生化科學研究所<br>107<br>Autophagy, a self-digestive mechanism, is vital for cellular functions and health. During starvation, autophagosomes form mainly at the endoplasmic reticulum (ER)-mitochondria contact sites. However, how cells timely induce autophagy at these sites are unclear. We aimed to elucidate the roles of ER and mitochondrial calcium-reactive oxygen species (ROS) signaling in autophagosome formation at these sites. We used confocal live-cell imaging to monitor autophagy activity in the absence or presence of calcium and ROS inhibitors. We found that autophagy activity b
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Hickey, Charlene. "Calcium influx and release controls neuroendocrine cell secretion and excitability." Thesis, 2009. http://hdl.handle.net/1974/5166.

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Ca2+ dynamics affect many critical cellular processes. In the bag cell neurons of Aplysia californica, intracellular Ca2+ is elevated during a prolonged period of firing known as the afterdischarge. This consists of a fast and slow phase of firing, which triggers peptide secretion and culminates in egg-laying. The present study examines how Ca2+ influx and release shape neurosecretion and membrane activity. Using capacitance tracking as an index of secretion, a 5 Hz, 1 min train, to mimic the fast phase, induced a clear elevation in the membrane surface area of cultured bag cell neurons. The
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"Role of agonist- and flow-induced caclium influx in vascular tone control." 2004. http://library.cuhk.edu.hk/record=b6073718.

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"2+" in the title is superscript.<br>"December 2004."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (p. 179-204)<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.
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