Gotowe bibliografie tematyczne / Inhibitor Activity

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Gotowa bibliografia na temat „Inhibitor Activity”

Autor: Grafiati

Data publikacji: 6 września 2023

Data aktualizacji: 31 lipca 2025

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Artykuły w czasopismach na temat "Inhibitor Activity"

Böhm, Martina, Manuela Krause, Charis Von Auer, Wolfgang Miesbach, and Inge Scharrer. "The Frequency and the Significance of ADAMTS-13 Neutralising Inhibitors in 62 Patients with Non-Familial Thrombotic Thrombocytopenic Purpura." Blood 104, no. 11 (2004): 3945. http://dx.doi.org/10.1182/blood.v104.11.3945.3945.

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Abstract Neutralising inhibitors against ADAMTS-13 are detected in 51–67% of patients with Thrombotic Thrombocytopenic Purpura (TTP). These ADAMTS-13 inhibitors have not been very well characterised and the diagnostic or the prognostic value of these inhibitors is not established. In the present study, we measured ADAMTS-13 activity and the corresponding inhibitor titer in 96 samples from 62 patients with TTP at various stages of their disease. All patients presented with non-familial TTP. For patients with severe ADAMTS-13 activity without detectable inhibitor heritable ADAMTS-13 deficiency w

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VARGA, Andrei, Camelia URDĂ, Ramona Dina GALBEN, et al. "Soybean Trypsin Inhibitor Activity - a review." Hop and Medicinal Plants 31, no. 1-2 (2023): 151–60. https://doi.org/10.15835/hpm.v31i1-2.14745.

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Soybean (Glycine max) is one of the most important source of protein for food and feed globally. Complete utilization of protein in human and animal digestion can be reduced by certain trypsin inhibitory (TI) substances present in fresh soybeans. Two classes of protease inhibitors (polypeptides) are found in soybeans: Kunitz trypsin inhibitor (KTI) and Bowman-Birk trypsin inhibitor (BBI). KTI is primarily responsible for its trypsin inhibitory activity, while BBI has been reported to have nutraceutical properties. The content of TI in soybean depends on the soybean genotype, environmental fact

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Domoney, C., and T. Welham. "Trypsin inhibitors in Pisum: variation in amount and pattern of accumulation in developing seed." Seed Science Research 2, no. 3 (1992): 147–54. http://dx.doi.org/10.1017/s0960258500001276.

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AbstractA survey of Pisum genotypes for seed trypsin inhibitors revealed a tenfold range in the extent of inhibition. Approximately 90% of trypsin inhibitory activity was associated with two albumin fractions in selected variant lines. The differences among extreme variants were consistent in three environments, between two sources of trypsin tested and whether expressed on a unit protein or dry weight basis.A study of the appearance of trypsin inhibitors during seed development in selected highand low-inhibitor lines showed differences in the accumulation pattern of active inhibitors. An endo

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Sumanadasa, Subathdrage D. M., Christopher D. Goodman, Andrew J. Lucke, et al. "Antimalarial Activity of the Anticancer Histone Deacetylase Inhibitor SB939." Antimicrobial Agents and Chemotherapy 56, no. 7 (2012): 3849–56. http://dx.doi.org/10.1128/aac.00030-12.

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ABSTRACTHistone deacetylase (HDAC) enzymes posttranslationally modify lysines on histone and nonhistone proteins and play crucial roles in epigenetic regulation and other important cellular processes. HDAC inhibitors (e.g., suberoylanilide hydroxamic acid [SAHA; also known as vorinostat]) are used clinically to treat some cancers and are under investigation for use against many other diseases. Development of new HDAC inhibitors for noncancer indications has the potential to be accelerated by piggybacking onto cancer studies, as several HDAC inhibitors have undergone or are undergoing clinical

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Pintus, Francesca, Delia Spanò, Angela Corona, and Rosaria Medda. "Antityrosinase activity ofEuphorbia characiasextracts." PeerJ 3 (October 13, 2015): e1305. http://dx.doi.org/10.7717/peerj.1305.

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Tyrosinase is a well-known key enzyme in melanin biosynthesis and its inhibitors have become increasingly important because of their potential use as hypopigmenting agents. In the present study, the anti-melanogenic effect of aqueous and ethanolic extracts fromEuphorbia characiasleaves, stems, and flowers in cell-free and cellular systems was examined. All the extracts showed inhibitory effects against mushroom tyrosinase with leaf extracts exhibiting the lowest IC50values of 24 and 97 µg/mL for aqueous and ethanolic extracts respectively. Enzyme kinetic analysis indicated that leaf aqueous ex

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Milner, Malgorzata, Jadwiga Chroboczek, and Wlodzimierz Zagorski-Ostoja. "Engineered resistance against proteinases." Acta Biochimica Polonica 54, no. 3 (2007): 523–36. http://dx.doi.org/10.18388/abp.2007_3226.

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Exogenous proteinase inhibitors are valuable and economically interesting protective biotechnological tools. We examined whether small proteinase inhibitors when fused to a selected target protein can protect the target from proteolytic degradation without simultaneously affecting the function and activity of the target domain. Two proteinase inhibitors were studied: a Kazal-type silk proteinase inhibitor (SPI2) from Galleria mellonella, and the Cucurbita maxima trypsin inhibitor I (CMTI I). Both inhibitors target serine proteinases, are small proteins with a compact structure stabilized by a

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Jang, Seong, Bill Strickland, Lynda Finis, et al. "Abstract 4014: Comparative biochemical kinase activity analysis identifies rivoceranib as the most selective VEGFR-2 inhibitor compared with other TKIs with known activity against VEGFR-2." Cancer Research 83, no. 7_Supplement (2023): 4014. http://dx.doi.org/10.1158/1538-7445.am2023-4014.

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Abstract Introduction: Vascular endothelial growth factor receptor 2 (VEGFR-2) is a key regulator of tumor angiogenesis that is highly expressed in several tumor types and is a known target for anti-cancer therapy. Yet the clinical use of VEGFR-2 inhibitors has been challenged by limited efficacy and various side effects, potentially due to the low selectivity of these TKIs for VEGFR-2. Thus, potent VEGFR-2 inhibitors with improved selectivity are needed. Rivoceranib is an oral tyrosine kinase inhibitor (TKI) that potently and selectively inhibits VEGFR-2. A comparison of the potency and selec

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Korn, J. H., K. M. Brown, E. Downie, Z. H. Liao, and D. L. Rosenstreich. "Augmentation of IL 1-induced fibroblast PGE2 production by a urine-derived IL 1 inhibitor." Journal of Immunology 138, no. 10 (1987): 3290–94. http://dx.doi.org/10.4049/jimmunol.138.10.3290.

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Abstract IL 1, a monocyte-derived cytokine, has potent biologic effects in a variety of target tissues. The existence of naturally occurring inhibitors of IL 1 activity has been recently described; these inhibitors blocked one IL 1 effect: stimulation of thymocyte responses to mitogens. We examined the effect of one well-characterized inhibitor of IL 1, isolated from the urine of febrile patients, on a second IL 1 effect, stimulation of fibroblast PGE synthesis. In this system, purified preparations of the urinary inhibitor that completely blocked murine thymocyte proliferative responses to mi

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Muller, Florian, Selvi Kunnimalaiyaan, Parth Mangrolia, and Jill Olson. "Abstract 5913: TEAD1/4 inhibitors exhibit deeper biological impact and broader activity compared to TEAD1-only inhibitors in both monotherapy and combination without additional kidney toxicity." Cancer Research 84, no. 6_Supplement (2024): 5913. http://dx.doi.org/10.1158/1538-7445.am2024-5913.

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Abstract The TEAD transcription factors in association with the YAP/TAZ co-activators drive the expression of pro-proliferative and pro-oncogenic genes that underlies the transformed phenotype of many carcinomas. In addition, YAP-TEAD transcriptional activity is emerging as a major resistance mechanism for diverse precision oncology drugs, with the most extensive data for resistance to drugs targeting the MAPK pathway. There is a strong interest in generating inhibitors of YAP/TEAD transcriptional activity with TEAD palmitic acid site inhibitors having demonstrated encouraging pre-clinical act

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Han, Di, Huiqun Wang, Wei Cui, Beibei Zhang, and Bo-Zhen Chen. "Computational insight into the mechanisms of action and selectivity of Afraxis PAK inhibitors." Future Medicinal Chemistry 12, no. 5 (2020): 367–85. http://dx.doi.org/10.4155/fmc-2019-0273.

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Aim: The p21-activated kinases (PAKs) are involved in many important biological activity regulations. FRAX019, FRAX414, FRAX597, FRAX1036 and G-5555 were identified as PAKs inhibitors. Their detailed inhibitory mechanisms deserve further investigation. Results: Molecular dynamics simulations and further calculations for the PAK1/inhibitor and PAK4/inhibitor complexes indicate that their binding free energies are basically consistent with the trend of experimental activity data. Conclusion: The anchoring of residues Leu347PAK1 and Leu398PAK4 is the structural basis for designing Afraxis PAK inh

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Rozprawy doktorskie na temat "Inhibitor Activity"

Stott, Holly Rosannah. "MMP-12 activity during vascular remodelling." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23609.

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Matrix metalloproteinases (MMPs) are required for tissue remodelling processes, including angiogenesis. MMP activity is generally proangiogenic but MMP-12 is suggested to be antiangiogenic and its precise role is still unclear. The work in this thesis describes the synthesis of an MMP-12 inhibitor and activity probe to address the hypothesis that MMP-12 inhibits angiogenesis. An inhibitor, synthesised in-house, selectively inhibited MMP-12 in in vitro recombinant enzyme assays. An activity probe, also synthesised in-house, was selective for MMP-12 in in vitro recombinant enzyme assays. The fun

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Eckelman, Brendan P. "The regulation of caspase activity by the inhibitor of apoptosis proteins." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3288846.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed June 2, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 188-214).

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Gora, Kasia G. (Kasia Gabriela). "SciP : a novel inhibitor of CtrA transcriptional activity in Caulobacter crescentus." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/68426.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, September 2011.<br>Cataloged from PDF version of thesis. "August 8, 2011."<br>Includes bibliographical references.<br>Cells must sense changes in their environment and respond appropriately in order to survive. A common survival strategy is for cells to translate an environmental signal into the activity of a transcription factor they effects a change in gene expression. In this way, cells can express a gene just-in-time for its biological function. In addition, cells can coordinate the activity of many transcription fac

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Al-Yousuf, Karamallah. "Investigating the anti-melanoma activity of combinatorial paclitaxel and MEK inhibitor." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/1be821d2-2436-4c31-8485-e62b86d6d33b.

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Melanoma has increased considerably over the past forty years. Traditional and newly-developed anti-melanoma drugs do not produce a satisfactory therapeutic response for the treatment of late stage melanoma. Nanomedicine is a potent tool for clinicians to circumvent many of the existing shortcomings in cancer therapy. Combination of more than one drug may maximise the therapeutic response and minimise undesirable effects of the chemotherapeutic agents in cancer patients. I developed a novel combinatorial approach that can be loaded into targeted anti-melanoma nanocarriers. Our group have been

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Sancho, Elena. "Conformation and activity of plasminogen activator inhibitor type 1 (PAI-1)." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU552562.

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Plasminogen activator inhibitor type 1 (PAI-1) is a unique member of the serpins in that it can adopt various conformations. It is synthesized as an active inhibitor which rapidly converts to a latent form that is not inhibitory. Conformational studies on this protein have been made difficult by this property. The production of recombinant PAI-1 was studied. The expression of r-PAI-1 by the bacterial strain MSD 1005 accounted for some 15-20% of the total cell protein, although some was produced in the form of inclusion bodies. As an attempt to improve the yields of PAI-1 antigen and activity,

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Mawlankar, R. "Polyphasic systematics of marine bacteria and their alpha-glucosidase inhibitor activity." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2020. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/5847.

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Microbes are the most diverse group of organisms present on the earth. Microbial diversity is the variety and variability of an organism’s and the ecosystem in which they occur. Microbes have been adapted to global environmental changes as and when it happened on the earth.The enormous microbial diversity also gives rise to a largely untapped amount of genetic information, bioactive compounds and biomaterials which could deliver important beneficial traits and applications of societal interest, for example, to improve the medical treatments,fisheries and aquaculture applications, supply of ene

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Grundy, Martin. "Activity of the aurora kinase B inhibitor AZD1152 in acute myeloid leukaemia." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12758/.

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Aurora kinases play an essential role in orchestrating chromosome alignment, segregation and cytokinesis during mitotic progression, with both aurora-A and B frequently over-expressed in a variety of human malignancies including those of leukaemic origin. Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells whose prognosis is particularly poor and where standard induction therapy has changed little over the past thirty years. This thesis evaluated the effects of AZD1152-hQPA (barasertib-hQPA), a highly selective inhibitor of aurora-B kinase, in AM

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Sampathkumar, Yamuna. "Thermal processing effects on total phenolic content, antioxidant activity, trypsin inhibitor activity and in-vitro protein digestibility of lentils." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107918.

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Heat pre-treatment of nutrient-rich lentil seeds prior to their processing into flour may enhance its use by reducing processing and preparation times in value added products. In this study, changes in trypsin inhibitor content, total phenolic content, antioxidant activity, and in-vitro protein digestibility of flours prepared from hulled red lentils and unhulled green lentils were determined subsequent to various processing methods such as oven roasting (OR), boiling and microwave heating (MH). The increasing interest in the phenolic content of plant based food-stuffs made us to assess two d

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Ren, Zhongyuan. "Small molecules regulated bone resorption and enzyme activity in osseous cells." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10291/document.

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La Cathepsine K est parmi la plus efficace des collagénases de mammifère pour cliver la triple hélice de collagène de type-1. Nous avons développé une série d'azanitriles, (CKI-8 and CKI-13) inhibiteurs de cathepsine K. CKI-8 (un isomère de CKI-13) et CKI-13 ne sont pas toxiques sur les osteoblastes Saos-2 et les cellules RAW 264.7 jusqu' à une concentration de 1000 nM, tandis qu'ils ne le sont pas jusqu'à une concentration de 100 nM sur les osteoclastes. CKI-8 n'affecte pas l'activité de la phosphatase alkaline ainsi que la minéralisation induite par les Saos-2 et par les osteoblastes primair

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Mendis, Mihiri Marini. "Variability in Arabinoxylan, Xylanase Activity and Xylanase Inhibitor Levels in Hard Spring Wheat." Thesis, North Dakota State University, 2012. https://hdl.handle.net/10365/26806.

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Arabinoxylans (AX), xylanase, and xylanase inhibitors have an important role in many cereal food processing applications. The effect of growing location (L), genotype (G), and their interactions (L ×G) on AX, apparent xylanase and apparent xylanase inhibition activities of <italic>Triticum aestivum</italic> xylanase inhibitor (TAXI) and xylanases inhibiting protein (XIP) of wheat was studied using six hard red spring wheat and six hard white spring wheat genotypes. Total AX content was largely dependent on L×G. In bran, xylanase activity, 25% of the variability could be attributed

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Książki na temat "Inhibitor Activity"

Roué, Gael. Activity of the Novel BCR Kinase Inhibitor IQS019 in B-NHL. LAP LAMBERT Academic Publishing, 2017.

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G, Cory Joseph, and Cory Ann H, eds. Inhibitors of ribonucleoside diphosphate reductase activity. Pergamon Press, 1989.

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Merton, Sandler, and Smith H. J. 1930-, eds. Design of enzyme inhibitors as drugs. Oxford University Press, 1994.

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Gupta, Satya Prakash. Matrix metalloproteinase inhibitors: Specificity of binding and structure-activity relationships. Springer, 2012.

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1935-, Tipper Donald J., ed. Antibiotic inhibitors of bacterial cell wall biosynthesis. Pergamon Press, 1987.

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Kiss, S., and M. Simihăian. Improving Efficiency of Urea Fertilizers by Inhibition of Soil Urease Activity. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-1843-1.

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Atwell, Mark M. Inhibition of secretary activity in cells isolated from the rat stomach. Aston University, Department of Pharmaceutical Sciences, 1990.

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M, Simihǎian, ed. Improving efficiency of urea fertilizers by inhibition of soil urease activity. Kluwer Academic Publishers, 2002.

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service), ScienceDirect (Online, ed. Constitutive activity in receptors and other proteins. Elsevier/Academic, 2010.

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Salehi, Sebastian Albert. Insulin secretion: Modulation of islet acid glucan-1,4-gas-glucosidase activity by selective inhibitors, Ca2+ and nitric oxide. Department of Pharmacology, Lund University, 1995.

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Części książek na temat "Inhibitor Activity"

Kruithof, E. K. O. "Plasminogen activator inhibitor activity assay." In ECAT Assay Procedures A Manual of Laboratory Techniques. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2992-3_18.

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Turecek, Peter, and Hans Peter Schwarz. "Factor Eight Inhibitor Bypassing Activity." In Production of Plasma Proteins for Therapeutic Use. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118356807.ch4.

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Darragh, A., M. Kenny, R. Lambe, T. Lenehan, I. Brick, and C. Maulet. "Indalpine, A New Serotonin Uptake Inhibitor." In Biological Psychiatry, Higher Nervous Activity. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-8329-1_50.

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Kluft, C., and P. Meijer. "Plasmin inhibitor activity (previously α2-antiplasmin)." In Laboratory Techniques in Thrombosis - a Manual. Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4722-4_28.

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Kaspari, Marion, and Elke Bogner. "Antiviral Activity of Proteasome Inhibitors/Cytomegalovirus." In Viral Proteases and Antiviral Protease Inhibitor Therapy. Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2348-3_4.

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Chelliah, Ramachandran, Eric Banan-MwineDaliri, and Deog-Hwan Oh. "Screening of Actinobacteria for Enzyme Inhibitor Activity." In Methods in Actinobacteriology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1728-1_69.

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Walker, Mark C., and James K. Gierse. "In Vitro Assays for Cyclooxygenase Activity and Inhibitor Characterization." In Methods in Molecular Biology. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-59745-364-6_11.

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Mirsky, Arthur. "The Insulinase and Insulinase-Inhibitor Activity of the Liver." In Novartis Foundation Symposia. John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470718858.ch19.

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Maxwell, Robert A., and Helen L. White. "Tricyclic and Monoamine Oxidase Inhibitor Antidepressants: Structure-Activity Relationships." In Handbook of Psychopharmacology. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-4045-4_3.

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Lacroix-Desmazes, S., A. Moreau, M. P. Horn, M. D. Kazatchkine, and S. V. Kaveri. "Factor VIII Inhibitor with Catalytic Activity towards Factor VIII." In Catalytic Antibodies. KARGER, 2000. http://dx.doi.org/10.1159/000058800.

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Streszczenia konferencji na temat "Inhibitor Activity"

Al Hashem, A., J. Carew, A. Al-Borno, and M. Brown. "The Synergistic / Antagonistic Effect of Water Treatment Chemicals on Corrosion Inhibition of Carbon Steel in the Water Injection System of West Kuwait Oil Fields." In CORROSION 2005. NACE International, 2005. https://doi.org/10.5006/c2005-05279.

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Abstract This study evaluated the corrosion inhibition of three corrosion inhibitors and particularly the influence of their complementary biocide and scale inhibitors to treat aquifer and effluent brines used in water injection systems of West Kuwait oil fields. The Rotating Cylinder Electrode (RCE) test was first used to measure the performance of the chemicals under shear conditions. The best two performing inhibitors were then tested in an autoclave to observe their performance under actual system pressure and temperature. In the RCE test the biocide and the scale inhibitors from each supp

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Kevyn Smith, J., and John L. Przybylinski. "The Effect of Common Brine Constituents on the Efficacy of Halite Precipitation Inhibitors." In CORROSION 2006. NACE International, 2006. https://doi.org/10.5006/c2006-06387.

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Abstract The influences of calcium, magnesium, and zinc ions on the efficacies of inorganic and organic based halite precipitation inhibitors are compared and contrasted. Calcium ion enhances the activity of the inorganic inhibitor and decreases the efficiency of the organic inhibitor. Magnesium has negligible influence on the efficacy of either inhibitor. Zinc, although not commonly found in oilfield brines, has a significant inhibitory influence on its own, but this influence is largely canceled by the presence of the organic or, especially, the inorganic halite inhibitor.

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Hollander, Orin, and Betz Industrial. "Structure-Activity Relationships of Triazole Copper-Corrosion Inhibitors: Rational Development of Enhanced Activity Inhibitors." In CORROSION 1989. NACE International, 1989. https://doi.org/10.5006/c1989-89455.

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Abstract A review of the chemistry of the aromatic triazoles and their behavior as copper corrosion inhibitors in aqueous systems is presented. Particular emphasis is placed on structure-activity relationships. Models of the inhibitive mechanism are discussed, and a new, alternative theory for the bonding of these compounds to the substrate is proposed. Applying this theory, a new inhibitor was developed, which had a greater overall inhibitive effect, but more importantly, a stronger bond to the substrate. This increase in the bond strength improved the durability of the film more than 50-fold

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Moon, Theodore, and David Horsup. "Relating Corrosion Inhibitor Surface Active Properties to Field Performance Requirements." In CORROSION 2002. NACE International, 2002. https://doi.org/10.5006/c2002-02298.

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Abstract Corrosion inhibitors for protecting oil and gas pipelines exhibit surface active behavior, and this surface activity affects not only their inhibition efficiency but also their ability to form and stabilize emulsions. Even though interfacial phenomena play a vital role, the interfacial properties of corrosion inhibitors have not been extensively examined with respect to their effect on corrosion inhibition and water quality. The work presented here has been designed to address some of these issues. Corrosion inhibitors are known to partition between oil and water phases. The amount of

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Durnie, W. H. "Modelling the Functional Behaviour of Corrosion Inhibitors." In CORROSION 2004. NACE International, 2004. https://doi.org/10.5006/c2004-04401.

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Abstract The inhibition efficiency of organic compounds is dependent on many factors, some of which include the molecular size, charge density, number of adsorption sites, and mode of interaction between the inhibitor and the surface. Adsorption at surfaces is linked predominantly to the electronic structure of the inhibitor molecules, and it is well known that slight changes in the chemistry of an inhibitor can instigate dramatic changes on its efficacy. Many different forms of quantitative structure activity relationships (QSAR’s) have been developed to describe the efficacy of corrosion inh

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Jenneman, Gary E. "A Novel Method for the Enhanced Kill of Sulfate Reducing Microorganisms." In CORROSION 2020. NACE International, 2020. https://doi.org/10.5006/c2020-14412.

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Abstract Hydrogen sulfide gas produced by sulfate reducing microorganisms (SRM) creates significant challenges in the petroleum industry including corrosion concerns, product devaluation, and significant health risks. Biocides and inhibitors are often employed to control these detrimental activities. Recently, co-injection of a synergistic blend of biocides and the SRM inhibitor, nitrite, was proposed as an effective means to control biogenic sulfide production, however, the method only addressed inhibition of SRM activity and not kill. Inhibition can have the undesirable consequence of allowi

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Jovancicevic, V., Y. S. Ahn, J. Dougherty, and B. Alink. "CO2 Corrosion Inhibition by Sulfur-Containing Organic Compounds." In CORROSION 2000. NACE International, 2000. https://doi.org/10.5006/c2000-00007.

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Abstract Corrosion inhibition of mild steel in CO2 environments by sulfur-containing compounds was studied using various laboratory performance test methods, inhibitor residual analysis techniques and a surface imaging technique. Corrosion rate-time/concentration profiles were obtained for several commercially available sulfur-containing inhibitors together with a proprietary thio compound. The role of chelation and redox chemistry of these inhibitors in corrosion inhibition is discussed in terms of the structure-activity relationship. A number of formulated products with sulfur-containing com

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Pandarinathan, Vedapriya, Kateřina Lepková, and Rolf Gubner. "Inhibition of CO2 Corrosion of 1030 Carbon Steel beneath Sand-Deposits." In CORROSION 2011. NACE International, 2011. https://doi.org/10.5006/c2011-11261.

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Abstract The performance of three corrosion inhibitors was investigated at 1030 carbon steel surfaces in the presence and absence of a sand deposit. Potentiodynamic measurements showed that the inhibition efficiency to mitigate corrosion reactions decreases in the presence of sand deposit. In contrary, the inhibitor performance was found to increase with longer exposure time of the steel to the corrosive media, at sand deposited surfaces. The differences between the steels corroded with and without sand deposit in the presence of an inhibitor were confirmed using both potentiostatic polarisati

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Nicolas, George, Amannie Kweik, and Zahid Amjad. "Inhibitory Activity of Biopolymers, Synthetic Polymers, and Phosphonates against the Formation of Calcium Phosphate Scale in Cooling Water Systems." In CORROSION 2017. NACE International, 2017. https://doi.org/10.5006/c2017-09013.

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Abstract The inhibition of calcium phosphate (Ca/P) precipitation by natural organic polyelectrolytes, bio- and hybrid polymers, homo- and co-polymers of acrylic acid and maleic acid containing different functional groups was examined in aqueous solution. Additionally, commonly used phosphonates were also evaluated as Ca/P inhibitors. It has been found that performance of additive (polymeric and non-polymeric) as Ca/P inhibitor depends upon additive concentration, ionic charge, and molecular weight. Based on the inhibition data, the ranking in terms of decreasing effectives is: biopolymer &amp

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Barr, Emily E., Alan H. Greenfield, and Leonard Pierrard. "Application of Electrochemical Noise Monitoring to Inhibitor Evaluation and Optimization in the Field: Results from the Kaybob South Sour Gas Field." In CORROSION 2001. NACE International, 2001. https://doi.org/10.5006/c2001-01288.

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Abstract Electrochemical noise monitoring produces real time corrosion data, which provides information both on the level of corrosion activity in a system and the dominant corrosion mechanism. This data can be used to efficiently evaluate corrosion inhibitor effectiveness and to optimize injection rates. This paper will present data obtained in Canada's Kaybob South Sour Gas field during inhibitor evaluation and optimization testing. Details of the field equipment setup and the data analysis process will be presented along with conclusions regarding inhibitor effectiveness and the field use o

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Raporty organizacyjne na temat "Inhibitor Activity"

Yibchok-anun, Sirintorn, and Nattaya Ngamrojanavanich. Structure-activity relationships of trans-cinnamic acid derivatives on inhibitions of alpha-glucosidase. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.86.

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Trans-Cinnamic acid and its derivatives were investigated for the a-glucosidase inhibitiory activity. 4-methoxy-trans-cinnamic acid and 4-methoxy-trans-cinnamic acid ethyl ester showed the highest potent inhibitory activity among those of trans-cinnamic acid derivatives. The presence of substituents at 4-position in trans-cinnamic acid derivatives. The presence of substituents at 4-position in trans-cinnamic acid altered the a-glucosidase inhibitory activity. Increasing of bulkiness and the chain length of 4-alkoxy substituents as well as the increasing of the electron withdrawing group have b

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Yongchaitrakul, Tassanee, and Prasit Pavasant. Effect of LPS of Actinobacillus actinomycetemcomitans lipopolysaccharide on matrix metalloproteinase-2 and changes of RANKL and OPG in HPDL cell. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.13.

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Background: The LPS of A.actinomycetemcomitans is one of the major pathogenic factors in periodontal disease. It induces secretion of pro-inflammatory cytokines and involves in alveolar bone destruction. We hypothesized that the LPS of A.actinomycetemcomitans could affect the activation of MMP-2 and the expression of RANKL and OPG in HPDL cells leading to the destruction of periodontium. Methods: HPDL cells were cultured in serum-free medium with or without the LPS of A.actinomycetemcomitans for 36 hours. The activation of MMP-2 was analyzed by zymography. Changes of the expression of RANKL an

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Yompakdee, Chulee, and Warintorn Chavasiri. An active compound Kempferia parviflora with inhibitory activity against GSK-3 kinase implicated in type II Diabetes and Alzheimer's disease. Chulalongkorn University, 2015. https://doi.org/10.58837/chula.res.2015.37.

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Calcium signaling pathways play pivotal roles in regulation of various important biological processes in eukaryotes ranging from yeast to human. Because of the high degree in gene conservation from yeast to human, the small molecule inhibitors discovered in the yeast based-drug screening system can be expected to exert their function in human as well. The immunosuppressive agents, FK506 and cyclosporine A, are an example. Our previous studies using a zds1 yeast-based assay to search for inhibitors in the calcium signaling pathway in Saccharomyces cerevisae mutant strain from the crude extract

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Shea, Lonnie D. Identification of a PARP Inhibitor Sensitivity Signature in Breast Cancer Using a Novel Transcription Factor Activity Array. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada559941.

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Olszewski, Neil, and David Weiss. Role of Serine/Threonine O-GlcNAc Modifications in Signaling Networks. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7696544.bard.

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Significant evidence suggests that serine/threonine-O-linked N-acetyl glucosamine0-(GlcNAc) modifications play a central role in the regulation of plant signaling networks. Forexample, mutations in SPINDLY,) SPY (an O-GlcNAc transferase,) OGT (promote gibberellin GA) (signal transduction and inhibit cytokinin responses. In addition, mutating both Arabidopsis OGTsSEC (and SPY) causes embryo lethality. The long-term goal of this research is to elucidate the mechanism by which Arabidopsis OGTs regulate signaling networks. This project investigated the mechanisms of O-GlcNAc regulation of cytokini

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Yibchok-anun, Sirinthorn, Wijit Banlunara, and Sirichai Adisakwattana. Antidiabetic effects, mechanisms of of p-methoxy-trans-cinnamic acid. Faculty of Veterinary Science, Chulalongkorn University, 2008. https://doi.org/10.58837/chula.res.2008.81.

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p-Methoxycinnamic acid (p-MCA) is a cinnamic acid derivative that shows various pharmacologic actions such as neuroprotective and hepatoprotective activities. To examine the insulinotropic activity of p-MCA, the perfused rat pancreas and a pancreatic β-cell line, INS-1 were used in the studies. P-MCA increased insulin secretion from the perfused rat pancreas and INS-1 cells in a concentration-dependent manner. In addition, p-MCA increased intracellular Ca²⁺ concentration ([Ca²⁺]i) in INS-1 cells. The p-MCA-induced insulin secretion and rise in [Ca²⁺]i were markedly inhibited in the absence of

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Farazi, Mena, Michael Houghton, Margaret Murray та Gary Williamson. Systematic review of the inhibitory effect of extracts from edible parts of nuts on α-glucosidase activity. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.8.0061.

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Review question / Objective: The aim of this review is to examine inhibitory effect of functional components in extracts from edible nuts on α-glucosidase activity. At the end of this review the following questions will be addressed by summarizing data of in-vitro studies: which nut extract has the strongest inhibitory effect? Which functional component (e.g. polyphenols) has the strongest inhibitory effect against α-glucosidase? Are there any differences between inhibition of α-glucosidase from different sources (e.g. yeast and mammalian)? Condition being studied: Any papers looking at inhibi

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Moran, Nava, Richard Crain, and Wolf-Dieter Reiter. Regulation by Light of Plant Potassium Uptake through K Channels: Biochemical, Physiological and Biophysical Study. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7571356.bard.

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The swelling of plant motor cells is regulated by various signals with almost unknown mediators. One of the obligatory steps in the signaling cascade is the activation of K+-influx channels -K+ channels activated by hyperpolarization (KH channels). We thus explored the regulation of these channels in our model system, motor cell protoplasts from Samanea saman, using patch-clamp in the "whole cell" configuration. (a) The most novel finding was that the activity of KH channels in situ varied with the time of the day, in positive correlation with cell swelling: in Extensor cells KH channels were

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Ori, Naomi, and Mark Estelle. Specific mediators of auxin activity during tomato leaf and fruit development. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597921.bard.

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The plant hormone auxin is involved in numerous developmental processes, including leaf and fruit development. The tomato (Solanumlycopersicum) gene ENTIRE (E) encodes an auxin-response inhibitor from the Aux/IAA family. While most loss-offunction mutations in Aux/IAA genes are similar to the wild type due to genetic redundancy, entire (e) mutants show specific effects on leaf and fruit development. e mutants have simple leaves, in contrast to the compound leaves of wild type tomatoes. In addition, e plants produce parthenocarpic fruits, in which fruit set occurs independently of fertilization

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กังสดาลอำไพ, อรอนงค์, та ธิติรัตน์ ปานม่วง. การเตรียมและการประเมินคุณค่าทางโภชนาการของอาหารทางการแพทย์ ชนิดผงสูตรโปรตีนสกัดจากถั่วเขียว : รายงานผลการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 1993. https://doi.org/10.58837/chula.res.1993.15.

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การศึกษานี้ได้เตรียมอาหารทางการแพทย์ชนิดผงสูตรโปรตีนสกัดจากถั่วเขียว โดยทดลองสกัดโปรตีนจากถั่วเขียว ซึ่งพบว่าควรสกัดโปรตีนด้วยสารละลายพีเอช 9 อัตรา ส่วนของถั่วเขียวต่อน้ำเป็น 1:15 นำโปรตีนที่สกัดได้ไปทดลองเตรียมอาหารทางการแพทย์ซึ่งสูตรที่ดีที่สุดมีส่วนผสมดังนี้ โปรตีนสกัดจากถั่วเขียว 20 กรัม น้ำมันข้าวโพด 16 กรัม เอ็มซีทีออยล์ 4 กรัม มอลโตเด็กซ์ตริน 42 กรัม น้ำตาลซูโครส 18 กรัม กลิ่นวานิลลา 0.2 กรัม เลซิธิน 2.3 กรัม เมไทโอนีน 0.38 กรัม และ ทรีโอนีน 0.22 กรัม นำส่วนผสมนี้มาปั่นผสมในน้ำ 1 ลิตร แล้วนำไปต้มเดือด 20 นาที เพื่อทำลาย Trypsin inhibitor activity นำส่วนผสมไปทำให้เป็นผงแห้งด้วยเครื่องทำแ

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