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1

Roué, Gael. Activity of the Novel BCR Kinase Inhibitor IQS019 in B-NHL. LAP LAMBERT Academic Publishing, 2017.

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2

G, Cory Joseph, and Cory Ann H, eds. Inhibitors of ribonucleoside diphosphate reductase activity. Pergamon Press, 1989.

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3

Merton, Sandler, and Smith H. J. 1930-, eds. Design of enzyme inhibitors as drugs. Oxford University Press, 1994.

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4

Gupta, Satya Prakash. Matrix metalloproteinase inhibitors: Specificity of binding and structure-activity relationships. Springer, 2012.

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5

1935-, Tipper Donald J., ed. Antibiotic inhibitors of bacterial cell wall biosynthesis. Pergamon Press, 1987.

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6

Kiss, S., and M. Simihăian. Improving Efficiency of Urea Fertilizers by Inhibition of Soil Urease Activity. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-1843-1.

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Atwell, Mark M. Inhibition of secretary activity in cells isolated from the rat stomach. Aston University, Department of Pharmaceutical Sciences, 1990.

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8

M, Simihǎian, ed. Improving efficiency of urea fertilizers by inhibition of soil urease activity. Kluwer Academic Publishers, 2002.

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9

service), ScienceDirect (Online, ed. Constitutive activity in receptors and other proteins. Elsevier/Academic, 2010.

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10

Salehi, Sebastian Albert. Insulin secretion: Modulation of islet acid glucan-1,4-gas-glucosidase activity by selective inhibitors, Ca2+ and nitric oxide. Department of Pharmacology, Lund University, 1995.

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11

P, Braquet, ed. CRC handbook of PAF and PAF antagonists. CRC Press, 1991.

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12

Mooney, Mark H. Glucagon-like peptide-1 and gastric inhibitory polypeptide: Effects of N-terminal glycation on hormone degradation, insulin secretion and antihyperglycaemic activity. The Author], 2000.

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13

Lennerstrand, Johan. Assays for reverse transcriptase activity and p53 protein: Applications for characterisation of HIV RT mutants and inhibitors, and for p53 expression in breast cancer. Acta Universitatis Upsaliensis, 1996.

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14

Mayhew, Christopher N. Evaluation of the anti-retroviral activity and bone marrow toxicity of the novel ribonucleotide reductase inhibitors trimidox and didox and comparison with hydroxyurea in murine acquired immunodeficiency syndrome. University of Wolverhampton, 2001.

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15

1935-, Tipper Donald J., ed. Antibiotic inhibitorsof bacterial cell wall biosynthesis. Pergamon, 1987.

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16

Takao, Kumazawa, Kruger Lawrence, and Mizumura Kazue, eds. The polymodal receptor: A gateway to pathological pain. Elsevier, 1996.

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17

Fleischmann, Roy. Signalling pathway inhibitors. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0081.

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Oral, small-molecule signalling pathway inhibitors, including ones that inhibit the JAK and SyK pathways, are currently in development for the treatment of rheumatoid arthritis (RA). Tofacitinib is an orally administered small-molecule inhibitor that targets the intracellular Janus kinase 3 and 1 (JAK1/3) molecules to a greater extent than JAK2 while baricitinib (formerly INCB028050) predominantly inhibits JAK1/2. Many of the proinflammatory cytokines implicated in the pathogenesis of RA utilize cell signalling that involves the JAK-STAT pathways and therefore inhibition of JAK-STAT signalling
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18

Majid, Adrian, and Bruce L. Gilliam. Future Antiretrovirals, Immune-Based Strategies, and Therapeutic Vaccines. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0023.

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Highly active antiretroviral therapy remains the mainstay of treatment for patients chronically infected with HIV. Novel drugs, both within existing classes and new ones, are in various stages of development and testing. New medications within existing classes of antiretroviral agents are in clinical trials and will likely offer activity against resistant HIV-1 strains and provide alternatives for combination pill therapy. Novel therapeutics including oral attachment inhibitors and monoclonal antibody treatments continue to show efficacy against HIV-1 and progress in clinical trials. Tenofovir
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19

Trus, Michael. Altering retinoid sensitivity in acute myeloblastic leukemia cells by treatment with the histone deacetylase inhibitor, valproic acid, and the inhibitor of DNA methyltransferase activity, 5-aza-2'-deoxycytidine. 2006.

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20

Mease, Philip. Biologic treatments for psoriatic arthritis apart from TNF inhibition. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0030.

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Psoriatic arthritis (PsA) is an immunologically mediated inflammatory disease characterized by arthritis, enthesitis, dactylitis, spondylitis, and psoriasis. Prior to the introduction of targeted biologic medications, such as TNF inhibitors, the ability to control disease activity was limited, with only modest effects noted with traditional oral medications such as methotrexate and sulfasalazine. The introduction of TNF inhibitors substantially changed the outlook of PsA patients, yielding significant response in all relevant clinical domains and demonstrating the ability to inhibit progressiv
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21

Keshav, Satish, and Palak Trivedi. Genetic liver disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0214.

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This chapter discusses three of the major inherited forms of liver disease (all autosomal recessive): hereditary haemochromatosis, Wilson’s disease, and alpha-1-antitrypsin deficiency. Hereditary haemochromatosis is characterized by excessive absorption of dietary iron, with a pathological increase in total body iron that accumulates in tissues and organs, disrupting their function. Wilson’s disease (hepatolenticular degeneration) is an autosomal recessive genetic disorder in which copper accumulates in tissues. Alpha-1-antitrypsin deficiency is characterized by reduced circulating levels of a
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22

(Editor), Merton Sandler, and H. John Smith (Editor), eds. Design of Enzyme Inhibitors As Drugs: Volume 2 (Design of Enzyme Inhibitors as Drugs). Oxford University Press, USA, 1994.

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23

Gupta, Satya Prakash. Matrix Metalloproteinase Inhibitors: Specificity of Binding and Structure-Activity Relationships. Springer, 2014.

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24

Böldicke, Thomas. Protein Targeting Compounds: Prediction, Selection and Activity of Specific Inhibitors. Springer London, Limited, 2016.

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25

Böldicke, Thomas. Protein Targeting Compounds: Prediction, Selection and Activity of Specific Inhibitors. Springer, 2016.

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26

Böldicke, Thomas. Protein Targeting Compounds: Prediction, Selection and Activity of Specific Inhibitors. Springer, 2018.

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27

(Editor), Gary A. Silverman, and David A. Lomas (Editor), eds. Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity. World Scientific Publishing Company, 2007.

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28

Lomas, David A. Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity. World Scientific Publishing Co Pte Ltd, 2007.

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29

Lomas, David A. Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity. World Scientific Publishing Co Pte Ltd, 2007.

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30

Eisen, Tim. The patient with renal cell cancer. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0172.

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Renal cancer is the commonest malignancy of the kidney and worldwide, accounts for between 2% and 3% of the total cancer burden. The mainstay of curative treatment remains surgery. There have been significant advances in surgical technique, the most important ones being nephron-sparing surgery and laparoscopic nephrectomy. The medical treatment of advanced renal cell cancer has only improved markedly in the last decade with the development of antiangiogenic tyrosine-kinase inhibitors, inhibitors of mammalian target of rapamycin, and a diminished role for immunotherapy.Tyrosine-kinase inhibitor
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31

Castellanos, Madeleine M. Female Sexual Biochemistry (DRAFT). Edited by Madeleine M. Castellanos. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190225889.003.0001.

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“Female Sexual Biochemistry” reviews the key hormones and neurotransmitters that have a major role in female sexuality. Estrogens—estradiol, estrone, and estriol—as well as major androgens, such as testosterone and dihydrotestosterone (DHT), are presented with a discussion of their role in the support of the reproductive organs and genitals as well as their actions on the central nervous system to affect sexual desire, arousal, and responsiveness. The interaction and regulation of estrogen by progesterone and thyroid hormone is included. A review of the dual-control model of sexual responsiven
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32

Cragoe, Edward J., and Thomas R. Kleyman. Amiloride and Its Analogs: Unique Cation Transport Inhibitors. John Wiley & Sons, 1993.

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33

Copeland, Robert A. Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists. Wiley & Sons, Incorporated, John, 2013.

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34

Borgnis, Ramie Lynn. Latent inhibition of multiple unit activity and EEG in rabbit hippocampus. 1993.

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35

Kiss, S., and M. Simihaian. Improving Efficiency of Urea Fertilizers by Inhibition of Soil Urease Activity. Springer, 2002.

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36

Kiss, S. Improving Efficiency of Urea Fertilizers by Inhibition of Soil Urease Activity. Springer, 2010.

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37

Kiss, S., and M. Simihaian. Improving Efficiency of Urea Fertilizers by Inhibition of Soil Urease Activity. Springer, 2013.

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38

Kiss, S., and M. Simihaian. Improving Efficiency of Urea Fertilizers by Inhibition of Soil Urease Activity. Springer London, Limited, 2013.

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39

Zhen, Liping. Hydrogen cyanamide on triphenyltetrazolium chloride reduction, sulfhydryl group binding, and catalase activity in bromegrass (Bromus inermis Leyss) cells. 1988.

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40

Herman, James P. Limbic Pathways to Stress Control. Edited by Israel Liberzon and Kerry J. Ressler. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190215422.003.0008.

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Appropriate control of the HPA (hypothalamo-pituitary-adrenocortical axis) is required for adaptation to physiological and environmental challenges. Inadequate control is linked to numerous stress-related pathologies, including PTSD, highlighting its importance in linking physiological stress responses with behavioral coping strategies. This chapter highlights neurocircuit mechanisms underlying HPA axis adaptation and pathology. Control of the HPA stress response is mediated by the coordinated activity of numerous limbic brain regions, including the prefrontal cortex, hippocampus, and amygdala
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41

Copeland, Robert A. Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists. Wiley & Sons, Incorporated, John, 2007.

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42

Copeland, Robert A. Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists. Wiley-Interscience, 2005.

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43

Copeland, Robert A. Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists. Wiley & Sons, Limited, John, 2013.

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44

Copeland, Robert A. Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists. Wiley & Sons, Incorporated, John, 2013.

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45

Copeland, Robert A. Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists. Wiley & Sons, Incorporated, John, 2005.

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46

Copeland, Robert A. Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists. Wiley & Sons, Incorporated, John, 2013.

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Copeland, Robert A. Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists. Wiley & Sons, Incorporated, John, 2013.

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48

Modulation of oscillatory activity in inhibitory neuronal networks by anesthetics: The role of receptor desensitization. National Library of Canada, 2001.

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Kumari, Seema. Isolation and Characterisation of Protoberberines with Antioxidant, Antiproliferative and Protease Inhibitory Activity from Berberis Aristata. GRIN Verlag GmbH, 2015.

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Test No. 224: Determination of the Inhibition of the Activity of Anaerobic Bacteria. OECD, 2007. http://dx.doi.org/10.1787/9789264067332-en.

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