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Rozprawy doktorskie na temat „Inhibitor”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Rodkey, Elizabeth A. "INHIBITOR RESISTANCE MECHANISMS AND INHIBITOR DESIGN IN ¿¿-LACTAMASES." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1354463033.

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2

Shkirskiy, Viacheslav. "Corrosion inhibition of galvanized steel by LDH - inhibitor hybrids : Mechanisms of Inhibitor Release and Corrosion Reactions." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066216/document.

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Le travail présenté essaie de comprendre les mécanismes de l’action d’un inhibiteur de corrosion présent dans un revêtement hybride sous forme de pigments intercalés dans les hydroxydes double lamellaires (HDL) pour la protection de l’acier galvanisé. Trois étapes clés ont été choisies pour ce travail : (1) l’identification d’un inhibiteur de corrosion hydrosoluble pour l’acier galvanisé avec une compréhension de sa réactivité, (2) la détermination des facteurs et des mécanismes contrôlant la libération de l’inhibiteur à partir d’HDL et (3) la compréhension des mécanismes de protection dans un

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3

Hirst, Claire Elizabeth 1971. "Tissue distribution and regulation of the granzyme B inhibitor, proteinase inhibitor 9." Monash University, Dept. of Biochemistry and Molecular Biology, 2002. http://arrow.monash.edu.au/hdl/1959.1/8488.

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4

Roweth, Harvey George. "Mechanisms of platelet inhibition by the selective serotonin reuptake inhibitor citalopram." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275477.

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Background: Selective serotonin reuptake inhibitor (SSRI) antidepressants prevent serotonin (5-HT) uptake by the serotonin transporter (SERT). Since blood platelets express SERT, SSRIs may modify platelet function and the risk of cardiovascular disease. However, the beneficial or adverse effects of SSRIs on arterial thrombosis are poorly characterised and detailed in vitro experimental data is limited. The SSRI citalopram is a racemate, the (S)-isomer being the more potent SERT inhibitor. Although citalopram has been shown to inhibit platelets in vitro, it is unclear whether this is mediated v

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5

Guzanov, Pavel. "ERAP1 inhibitor development." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:e4369016-ab8f-445d-ab1a-71129b495a37.

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ERAP1 has been associated with a set of immune-mediated diseases, including ankylosing spondylitis. Currently, there is no selective and potent ERAP1 inhibitor available that would allow in-depth research of its functions and roles in diseases. Therefore, the aim of this work is to apply fragment-based drug design approach for the development of such inhibitor. A set of 12 structurally diverse hits was identified as a result of a screen containing 1200+ fragments using orthogonal ERAP1 activity assays. These hits can be used as a basis for development of a larger lead inhibitor, which requires

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6

Clarke, Tyler Brooke. "Studies on the inhibitor selectivity and inhibitory signal transfer of a-Isopropylmalate synthase." Thesis, University of Canterbury. Chemistry, 2013. http://hdl.handle.net/10092/11303.

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α-Isopropylmalate synthase (α-IPMS) is responsible for catalysing the first committed step in leucine biosynthesis. This pathway is found in plants and microorganisms, including pathogenic bacteria such as Mycobacterium tuberculosis and Neisseria meningitidis. α-IPMS catalyses a Claisen condensation reaction between α-ketoisovalerate (KIV) and acetyl coenzyme A (AcCoA) to form the product α-isopropylmalate (IPM). This enzyme undergoes feedback inhibition by the end product of the pathway, leucine. This regulation allows the control of the rate leucine biosynthesis. This project focuses on the

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7

Menon, V. "Molecular and functional aspects of hydrolyases / inhibitors with emphasis on aspartic protease inhibitor." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2012. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2401.

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8

Miyazaki, Hiroshi. "Studies on Inhibitors of Plasminogen Activator Inhibitor-1(PAI-1) and Inhibitors of PAI-1 Production as Antithrombotic Agents." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/126818.

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9

Ahtyamova, Daria. "Cholinesterase inhibitor: pharmacological application." Thesis, Київський національний університет технологій та дизайну, 2019. https://er.knutd.edu.ua/handle/123456789/13033.

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10

McCready, Tara Lyn. "Inhibition of protein phosphatase-1 by endogenous inhibitor proteins and natural product toxins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0032/NQ46885.pdf.

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11

Chen, Ping. "Inhibitor adsorption study and the effect of inhibitor on kinetics of BaSO4 crystal growth." Thesis, Heriot-Watt University, 1995. http://hdl.handle.net/10399/1336.

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12

Poliakov, Anton. "Peptide-Based Inhibitors of Hepatitis C Virus NS3 Serine Protease: Kinetic Aspects and Inhibitor Design." Doctoral thesis, Uppsala universitet, Institutionen för naturvetenskaplig biokemi, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4127.

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Hepatitis C is a serious disease that affects about 200 million people worldwide. No anti-HCV vaccine or specific anti-viral drugs are available today. Non-structural protein 3 (NS3) of HCV is a bifunctional serine protease/helicase, and the protease has become a prime target in the search for anti-HCV drugs. In this work, the complete HCV NS3 gene has been cloned and expressed, and the protein has been purified using affinity chromatography. An assay for measuring the protease activity of full-length NS3 protease has been developed and used for inhibition studies. A series of peptide-based in

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13

Schempp, Christina Maria. "The V-ATPase inhibitor archazolid." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-168586.

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Fighting metastasis is a major challenge in cancer therapy and novel therapeutic targets and drugs are highly appreciated. Resistance of invasive cells to anoikis, a particular type of apoptosis induced by loss of cell-extracellular matrix (ECM) contact, is a major prerequisite for their metastatic spread. Inducing anoikis in metastatic cancer cells is therefore a promising therapeutic approach. The vacuolar H+-ATPase (V-ATPase), a proton pump located at the membrane of acidic organelles, has recently come to focus as an anti-metastatic cancer target. As V-ATPase inhibitors have shown to prev

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14

Cao, Xianhua. "Simultaneously targeting hypoxic cancer cells by hsp90 inhibitor and glycolysis inhibitor in pancreatic cancer therapy." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1173117669.

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15

Kreienbühl, Peter Lukas. "Protein phosphatase inhibitor okadaic acid alters cell shape and F-action distribution and inhibits /." Bern, 1992. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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16

Reid, Anne Marie. "Raf-1 kinase inhibitor protein modulation of the cellular response to chemotherapeutic drugs and PDE5 inhibitors." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2497/.

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RKIP was initially discovered as an endogenous inhibitor of the ERK and NF-κB pathways,and was also shown to prolong the activation of GPCRs via inhibition of the GRK2 protein. Now increasing evidence has linked RKIP to a metastases suppressing and chemo-sensitising role in cancer cells.The chemo-sensitising effect of RKIP was investigated in a colon carcinoma cell line using a variety of chemotherapeutic agents from conventional agents to newer targeted therapies. Initial results suggested that role of RKIP in the modulation of chemotherapeutic drug response was at the level of apoptosis; the

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17

Haworth, Caroline Joanne. "Cloning and expression of a modified oryzacystatin inhibitor gene and an investigation of its inhibitory capabilities." Doctoral thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/9485.

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Bibliography: leaves 128-146.<br>Cysteine proteinase inhibitors have shown potential as biocontrol agents for the protection of plants against insect and pathogen attack. With the advent of protein and genetic engineering such inhibitors can now be modified in order to improve their effectiveness. Because cystatins have already been isolated from plants. they provide a good starting point for developing modifications which may improve their function as biocontrol agents. The purpose of this project, therefore, was to design a potentially improved analogue of the rice cysteine proteinase inhibi

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18

Dabos, Maria Laura Belen. "Structural and functional insights into the substrate specificity of OXA-48-like carbapenemases." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS402/document.

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Les b-lactamines, grâce à leur efficacité clinique, sont parmi les antibiotiques les plus prescrits pour traiter des infections bactériennes. Cependant, leur utilité est compromise par la prolifération des b-lactamases (BLs) avec des profils d’hydrolyse de substrats très larges. La résistance induite par les BLs compromet également les b-lactamines les plus puissantes (c-à-d les carbapénèmes). OXA-48, une carbapénèmase de classe D (CHDL), a été initialement identifiée dans une souche de K. pneumoniae de Turquie en 2001. OXA-48 hydrolysent fortement les pénicillines, faiblement les carbapénèmes

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19

Furnish, Robin. "Evaluating Immune Modulatory Therapeutic Strategies for Diffuse Intrinsic Pontine Glioma." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595849080346532.

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20

Freeman, Thomas Charles. "Studies of pancreatic secretory trypsin inhibitor." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46304.

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21

Alotaibi, Fahad T. "Plasminogen activator inhibitor-1 in endometriosis." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59961.

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Endometriosis is a disease that affects almost 10% of reproductive-age women, where 50 % of these women have pelvic pain with sexual intercourse. Deep endometriosis is defined as an endometriotic lesion penetrating to a depth of 5 mm or more, and is characterized by both fibrosis (forming nodules) and invasion (into structures such as the colon). Other groups have found that increased plasminogen activator inhibitor-1 (PAI-1) or (SERPINE1) expression was associated with fibrosis and tumor invasion. In addition, a previous study found that the SERPINE1 4G allele (and thus increased gene express

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22

Izzi, Luisa. "CEACAM1 as a tumor cell inhibitor." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ55070.pdf.

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23

Holmes, David Ian Roderick. "Phage display of chymotrypsin inhibitor II." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283414.

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24

Gariani, Talal. "Design of serine protease inhibitor peptides." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267244.

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25

Boak, Lorraine Scott. "Factors that impact scale inhibitor mechanisms." Thesis, Heriot-Watt University, 2013. http://hdl.handle.net/10399/2670.

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The formation of mineral scales such as barium sulphate and calcium carbonate remains an issue for the oil industry, after many years of oil exploration. In the last 10 years, the difficulty in dealing with scale deposition has been accentuated by the appearance of more complex conditions, involving complicated well completions for deepwater or long sub-sea tiebacks. If scale control measures fail in these situations then long distances between the scale deposits and the production platform are present. Intervention into such systems is either impossible or extremely expensive. To combat such

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26

Christofakis, Steven. "SCRIBBLE: A POTENTIAL DUAL KINASE INHIBITOR." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/72.

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Extracellular signal-regulated kinases (ERKs) modulate cellular activities in response to extracellular stimuli and play important biological roles. Thus, perturbed kinase pathways induce pathological conditions, such as tumor development. Rit, a novel member of the Ras family GTPases, activase ERK6, and its over-expression confers tumorigenicity. We hypothesized the presence of scaffolding molecules specific to ERK6, similar to other known MAP kinases. We performed yeast two-hybrid assays using ERK6 as bait, and Scribble was identified as a binding partner. Scribble contains 16 LRR domai

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27

Chee, Lai Yuen. "p53, a novel inhibitor of apoptosis." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6835.

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p53 is a transcription factor known to induce apoptosis via transactivating the expression of pro-apoptotic proteins and by directly activating the mitochondria apoptotic pathway. p53 is also found to be mutated in 50% of human cancers with some of these tumours overexpressing both wild type (WT) and mutant p53. Overexpression of the p53 protein has been implicated with the more aggressive nature of these tumour cells, suggesting a possible gain-of-function of such mutants. In this study, the involvement of p53 in apoptosis via the caspase pathway was investigated. WT-p53 and three mutant p53

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28

He, Hua, and 何華. "Anti-tumor mechanisms of cyclooxygenase inhibitors and a c-Jun-N-terminal kinase inhibitor in gastrointestinal cancers." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30075245.

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29

Roever, Lisa. "Inhibitor Studies for 5’-ecto-nucleotidase (CD73)." Ohio University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1553892946798977.

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30

Noma, Naruto. "Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells". 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225446.

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31

Tuck, Benjamin. "Investigating Multispecies Biofilms on Steel Surfaces in Seawater and Biofilm Inhibition by a Novel, Multifunctional Inhibitor." Thesis, Curtin University, 2022. http://hdl.handle.net/20.500.11937/89066.

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Biofilm formation is a global, $multi-billion phenomenon spanning a plethora of stakeholders. This thesis investigates critical fundamental aspects of biofilm formation on steel and evaluates the efficacy of a novel, environmentally sustainable and multifunctional inhibitor compound developed through a broader Australian Research Council Discovery Project collaboration. Focused on sustainable and effective biofilm disruption, results from this thesis are used to expand fundamental knowledge and generate a targeted approach to biofilm mitigation that improves biocide function.

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32

Geng, Xinyan. "Investigations into how best to target FGFR2 mutant endometrial cancer." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/123437/1/Xinyan%20Geng%20Thesis.pdf.

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Endometrial cancer (EC) is the fourth most common cancer in women in developed countries, such as North America, Europe and Australia. Patients with low-grade, early-stage disease usually have a favourable survival rate. However, patients that present at an advanced stage of disease have an average survival of only 12 months. Current treatments for these patients are radiation and chemotherapy, which offer limited clinical benefit. There is no efficient treatment for advanced EC. Improved therapeutic approaches are needed for the treatment of recurrent and metastatic endometrial cancer. Recent

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33

Nakahira, Marcel. "Caracterização físico-química e estrutural do SbKI, um inibidor de serinoproteases de sementes de barbatimão (Stryphnodendron barbatiman)." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-01042014-174549/.

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Os inibidores de proteases desempenham nas plantas funções como: defesa contra ataque de predadores de sementes, regulação de enzimas endógenas e fontes de proteínas e aminoácidos. Muitos destes inibidores são utilizados em estudos bioquímicos, bem como no tratamento de patologias humanas como inflamação e câncer. Neste trabalho, um inibidor de serinoprotease, presente na semente de Stryphnodendron barbatinan (barbatimão), foi purificado, caracterizado e denominado SbKI. Sementes de barbatimão maduras foram trituradas, até a obtenção de uma farinha, e esta foi suspensa em PBS, pH 7,4 (1 :5 m/v

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34

Dawson, Sally. "Genetic variation at the plasminogen activator inhibitor-1 locus and its effect on plasminogen activator inhibitor-1 expression." Thesis, Imperial College London, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298676.

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35

McLaren, Lorna J. "The mouse protein phosphatase inhibitor-1 gene." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/24958.

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Intracellular proteins are phosphorylated by kinases and dephosphorylated by phosphatases. Protein phosphatase inhibitor-1 (I-1) inhibits protein phosphatase-1 (PP-1), thereby increasing the phosphorylated state of proteins in the cell. The initial aim of the work reported here was to determine whether I-1 is a kidney 'stem' cell marker (Svennilson <i>et al.,</i> 1995); if so, it would be the first unique marker for these cells. The project involved characterizing the protein coding region of the mouse I-1 gene, determining the I-1 protein expression pattern in the developing mouse embryo and

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36

Montgomerie, Harry. "Novel inhibitor chemistry for oilfield scale application." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/24277/.

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The body of work presented here is focussed on five published papers which address solving inorganic scale problems experienced by the North Sea oil industry with a focus on the Norwegian Continential Shelf (NCS) over the last ten years or so. The degree of increasing difficulty in addressing issues of serious barium sulphate scaling, in the reservoir and wellbore areas, complicated by seawater breakthrough, the authorities demand for improvement in environmental properties of the chemistries deployed, the cost driven push for longer treatment life and with the increasing awareness of the dama

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37

Davies, Glyn Daniel. "Inhibitor studies on para-aminobenzoic acid synthase." Thesis, University of Cambridge, 2003. https://www.repository.cam.ac.uk/handle/1810/265461.

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Para-aminobenzoic acid (PABA) synthase is a three-subunit enzyme system that catalyses the conversion of chorismic acid top-aminobenzoic acid in plants and microorganisms. P ABA is then incorporated into folic acid an essential nutrient for mammals and utilised in the transfer of one-carbon units. For this reason it is a potential target for herbicidal and antibiotic development. A glutamine amidotransferase and ADC synthase form a heterodimeric complex and carry out the amino substitution reaction to yield 4-amino-4-deoxychorismate (ADC). A separate subunit, ADC lyase, then carries out the el

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38

Mahmoodi, Niusha. "Indole prenyltransferases : mechanistic studies and inhibitor design." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/55872.

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The cyclic dipeptide N-prenyltransferase (CdpNPT) catalyzes the reverse C-3 prenylation of a variety of cyclic dipeptides and benzodiazepinediones. A previous study misassigned the structure of the product of this reaction. In this work, the true product of the CdpNPT-catalyzed reaction between cyclo-L-Trp-L-Trp and dimethylallyl diphosphate (DMAPP) is identified as a C-3 reverse prenylated species. Furthermore, the non-enzymatic Cope/aza-Cope rearrangement of the CdpNPT product was examined under acidic conditions. Our results indicated that only the aza-Cope rearrangement onto the N-1 positi

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39

Cho, Park 1975. "The Cap-binding inhibitor of translation, d4EHP /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111819.

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In eukaryotes, the initiation phase of protein synthesis or translation is a multi-step process that culminates in the positioning of the SOS ribosome at the initiation codon of a messenger RNA (mRNA). Recognition of the cap structure by eukaryotic initiation factor 4F (etF4F; composed of three subunits: the cap-binding protein e1F4E, the RNA-helicase eIF4A and the scaffolding protein eIF4G) facilitates this process. The ability of eIF4F to bind to the cap, as a result of the Cap:eIF4E interaction is of particular importance, as it is the major target of translational regulatory mechanism.<br>

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Sirry, Baheya. "Regulation of the translational inhibitor 4E-BP1." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79128.

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Regulation of translation has long been recognized as a crucial event in the control of gene expression. It allows for rapid changes in gene expression in response to a wide-range of extracellular stimuli. Variations in nutrient availability for instance are detected and transmitted through the protein kinase FRAP/mTOR to key translational regulators such as the CAP-dependent translation inhibitor 4E-BP1. 4E-BP1 function is regulated mainly by phosphorylation. The focus of this thesis is to better understand signalling involved in 4E-BP1 regulation.<br>We first decided to examine 4E-BP1

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41

Patient, Michaela Eileen. "Rcd, a ColE1-encoded cell division inhibitor." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309210.

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42

Duncan, S. J. "Structural studies on a p53-MDM2 inhibitor." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598682.

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The 53 kDa phosphoprotein, p53 plays a critical role in the regulation of cell proliferation and development of genetic abnormalities by inducing G1 arrest or apoptosis in response to DNA damage. It also forms a stable complex with the MDM2 protein, in which state, the transactivation domain of p53 is concealed from the transcriptional machinery and is unable to induce G1 arrest or apoptosis. p53 activates the transcription of the <I>mdm2</I> gene, so the levels of MDM2 and the activity of p53 are kept under the control of an autoregulatory feedback loop. When overexpressed, MDM2 acquires tumo

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43

Panahloo, Archia. "Plasminogen activator inhibitor-1 and cardiovascular risk." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286442.

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44

Bevan, A. W. "Specificity of inhibitor binding to dihydrofolate reductase." Thesis, University College London (University of London), 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.352532.

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45

Potter, Garrett. "Chemical synthesis of a mimetic heparanase inhibitor." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/chemical-synthesis-of-a-mimetic-heparanase-inhibitor(6802b624-c3c0-4209-9c6d-bbcebf8e2d0b).html.

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Heparanase (Hpa1) is an enzyme overexpressed in nearly all cancers, typically at the tumour growth front. It cleaves proteoglycan heparan sulfate (HS) chains to release growth factors necessary for tumour growth. While some carbohydrate-based mimetic inhibitors have progressed to advanced clinical trials, new inhibitors and tools to further investigate heparanase are of continued interest. This thesis proposes a HS mimetic trisaccharide sequence that can bind Hpa1 and is suitable both for biological evaluation and inhibitor development. Synthetic work was then undertaken toward the progression

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46

Campbell, A. F. "Protein engineering of chymotrypsin inhibitor II (C12)." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/46983.

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陳恒琦. "Studies on the Inhibitory Mechanism of Angiogenesis Inhibitor, endostatin." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/08355482627008954517.

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碩士<br>國立中山大學<br>生物科學研究所<br>89<br>Antiangiogenic tomor therapies have attracted intense interest for their broad-spectrum action, low toxicity, and in the case of direct endothelial targeting, and absence of drug resistance. Among the growing list of antiangiogenic agents, endostatin has attracted most attention and been under the spotlight of numerous debates. Like other angiogenesis inhibitors, endostatin is also a proteolytic fragment (~20 kDa) from an extracellular protein, collagen XVIII. It potently inhibits endothelial cell proliferation and angiogenesis, but has no cytotoxic effects

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Chen, Heng-Chi James, and 陳恒琦. "Studies on the Inhibitory Mechanism of Angiogenesis Inhibitor, Endostatin." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/20681125193868341554.

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碩士<br>國立中山大學<br>生物科學系研究所<br>88<br>Antiangiogenic tomor therapies have attracted intense interest for their broad-spectrum action, low toxicity, and in the case of direct endothelial targeting, an absence of drug resistance. Among the growing list of antiangiogenic agents, endostatin has attracted most attention and been under the spotlight of numerous debates. Like other angiogenesis inhibitors, endostatin is also a proteolytic fragment (~20 kDa) from an extracellular protein, collagen XVIII. It potently inhibits endothelial cell proliferation and angiogenesis, but has no cytotoxic effects on

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Hua, Tzu-Yu, and 華梓佑. "Structures of NP exonuclease-inhibitor complex reveal the unique inhibition mechanism by a covalent bond between cysteine and inhibitor." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/b95fht.

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碩士<br>國立交通大學<br>生物資訊及系統生物研究所<br>105<br>The Nucleoprotein exonuclease ( NP exonuclease ) of Lassa virus is involved in viral genomic RNA encapsidation, viral RNA synthesis and host immune evasion. NP exonuclease is constituted by N-terminal and C-terminal domains, of which the main function of N-terminal domain is to capture the 5' cap of mRNA in the host cell for carrying out transcription and replication of its own viral RNA; the C-terminal domain of NP exonuclease belongs to the DEDDh exonuclease family. The C-terminal domain is used to degrade pathogen associated molecular patterns generate

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Lapinska, Karolina Eva. "Anti-ovarian cancer effects of histone deacetylase inhibitors and calpain inhibitor." Thesis, 2016. https://hdl.handle.net/2144/14609.

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Ovarian cancer is the leading cause of death among gynecologic malignancies. The risk of developing ovarian cancer in a woman’s lifetime is 1 to 2 in 100. This high rate of development and death from the tumorigenesis is a result of its asymptomatic manifestation. Ovarian cancer is usually found in its advanced stage; therefore the survival rate is lower than for other types of cancers. The most common type of ovarian cancer, serous epithelial ovarian cancer, arises from the surface epithelium of the ovary and less frequent from the fallopian tubes or uterus. The treatment of surgery is limite

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