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Rozprawy doktorskie na temat „Insulin and non insulin”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Gormley, M. J. J. "Aspects of insulin treatment of non-insulin-dependent diabetes." Thesis, Queen's University Belfast, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373006.

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2

Baynes, Christospher. "Insulin action and dyslipidaemia in non-insulin-dependent diabetes." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316405.

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3

Al-Hussary, Nabeel A. J. "Insulin receptor binding in hypertension and non-insulin dependent diabetes mellitus." Thesis, Aston University, 1986. http://publications.aston.ac.uk/14510/.

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4

Wortell, Linda Harbaugh. "Health beliefs of insulin dependent diabetics and non-insulin dependent diabetics." Thesis, The University of Arizona, 1987. http://hdl.handle.net/10150/276650.

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The descriptive study which explored the insulin dependent diabetics' and non-insulin dependent diabetics' perceptions of susceptibility to diabetic complications, severity of diabetes, and benefits of and barriers to preventive measures. The Wortell Diabetic Perception Scale was developed by the researcher for this study, and administered to a convenience sample of 71 subjects. The Subjects' age ranged from 22 to 80 years. There were 33 females and 38 males in the sample. Forty three percent of the diabetics were classified as insulin dependent diabetics and 57% as non-insulin dependent diabe

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5

Petrie, John Ross. "Serum insulin concentrations, insulin sensitivity, and endothelial function in essential hypertension and non-insulin-dependent diabetes mellitus." Thesis, University of Glasgow, 1997. http://theses.gla.ac.uk/2846/.

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A series of studies is described in which specific and conventional insulin immunoassays, the hyperinsulinaemic clamp technique and forearm venous occlusion plethysmography with local intra-arterial infusions have been used to investigate: the effect of insulin assay specificity on the relationships among serum insulin concentrations, insulin sensitivity, and blood pressure in diabetic and non-diabetic subjects with and without essential hypertension (Chapter 5) the effect of sustained physiological activation of the renin-angiotensin system induced by moderate dietary sodium restriction on in

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6

Whitelaw, Donald C. "Aspects of insulin secretion and action in non-insulin-dependent diabetes mellitus." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/22738.

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In a cross-sectional survey of coronary risk factors in subjects with recently diagnosed NIDDM I confirm the high prevalence of individual risk factors described by others, and show a broadly normal distribution pattern for the clustering of risk factors forming Reaven's Syndrome X, in contrast to that reported in other populations. I suggest that hyperinsulinaemia and hypertriglyceridaemia are the best markers of high coronary risk and note the association of obesity and other risk factors. In a study to examine the effects of the new oral hypoglycaemic drug A4166 in NIDDM I confirm its major

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7

Frangioudakis, Georgia St Vincent's Clinical School UNSW. "Insulin signal transduction in vivo in states of lipid-induced insulin resistance." Awarded by:University of New South Wales. St Vincent's Clinical School, 2004. http://handle.unsw.edu.au/1959.4/27419.

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Insulin resistance is the major metabolic defect in obesity and Type 2 diabetes. Increased lipid accumulation is strongly associated with insulin resistance. A significant component of insulin resistance is thought to be a reduced ability of insulin to activate the cascade of phosphorylation events that lead to the metabolic effects of this hormone. The broad aims of this thesis were to examine the effect of high-fat diets containing different fat subtypes on in vivo insulin signalling, under conditions normally used to detect whole body insulin resistance, and to compare the effects of acute

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8

Song, Xiao Mei. "Insulin signal transduction in skeletal muscle : special consideration for insulin resistance and diabetes /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4502-0/.

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9

James, Declan Jonathan. "An analysis of insulin- and non-insulin- stimulated glucose transport in rat skeletal muscle." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394962.

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10

Gelding, Susan Valerie. "Metabolic abnormalities preceding non-insulin dependent diabetes." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283202.

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11

Beatty, Olivia Louise. "Aspects of insulin resistance, insulin secretion and microalbuminuria in diabetic, hypertensive and non-diabetic subjects." Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484068.

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12

Baba, Reizo, Masaaki Koketsu, Masami Nagashima, Akiko Tamakoshi, and Hiroshi Inasaka. "Role of Insulin Resistance in Non-Obese Adolescents." Nagoya University School of Medicine, 2010. http://hdl.handle.net/2237/14178.

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13

McGurk, Colm. "Endothelial function in non-insulin dependent diabetes mellitus." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387879.

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14

Pinkney, Jonathan Henley. "Origins of hypertension in non-insulin dependent diabetes." Thesis, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286682.

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15

Alcolado, Juan Carlos. "The genetics of non-insulin dependent diabetes mellitus." Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358901.

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16

Jaap, Alan James. "Microvascular function in non-insulin-dependent diabetes mellitus." Thesis, University of Glasgow, 1994. http://theses.gla.ac.uk/30732/.

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Epidemiological studies suggest differences in the prevalence and natural history of microvascular complications between subjects with insulin dependent (IDDM) and non-insulin dependent (NIDDM) diabetes. The haemodynamic hypothesis proposes that early functional changes in the microcirculation result in the eventual development of diabetic microangiopathy. There is now a large body of experimental evidence in support of this hypothesis in patients with IDDM, with abnormalities in blood flow, capillary pressure and permeability having been demonstrated. In contrast, there have been few studies

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17

Bossetti, Brenda. "Levels of insulin-like growth factor I in non-insulin dependent diabetic and non-diabetic female subjects following an energy restricted diet /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu148777503417742.

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18

Dornhorst, Anne. "Gestational diabetes : a model of non-insulin dependent diabetes." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334887.

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19

Tan, Kathryn Choon Beng. "Postprandial lipoprotein metabolism in non-insulin-dependent diabetes mellitus." Thesis, Cardiff University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323795.

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20

Tovi, Jonas. "Insulin treatment of elderly type 2 diabetic patients /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3237-9/.

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21

Salgin, Çağrı Burak. "The relationship between non-esterified fatty acid levels, insulin secretion and insulin sensitivity with risk of type 2 diabetes." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611806.

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22

Bagstaff, Stephanie M. "Hyperinsulinemia and insulin resistance in cultured human muscle cells." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270177.

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23

Wilson, M. "Patient education and compliance in non-insulin dependent diabetes mellitus." Thesis, University of Surrey, 1991. http://epubs.surrey.ac.uk/844504/.

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This prospective study investigated many compliance-related aspects involving a population of Type II (non-insulin-dependent) diabetics, who attended the out-patients' clinic of a District General hospital. The investigations were undertaken from both qualitative and quantitative perspectives; activities within the clinic were observed and knowledge levels concerning diabetes mellitus were measured. A teaching programme was constructed, drawing on general educational principles; each stage was subjected to analysis and evaluation. Information, teaching and counselling skills were incorporated

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24

Kalidas, Kamini. "A molecular genetic study of non-insulin dependent Diabetes Mellitus." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266168.

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25

Mackie, Alasdair David Ramsay. "The progression of nephropathy in non-insulin-dependent diabetes mellitus." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/21383.

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The natural history and factors affecting the progression of nephropathy in non-insulin-dependent diabetes mellitus are poorly understood. The hypothesis that glomerular filtration declines at a similar rate in NIDDM and IDDM was examined in a cohort of 87 subjects (55 NIDDM and 32 IDDM). The rate of decline of calculated GFR (Cockcroft-Gault) was significantly slower in IDDM compared to NIDDM (0.29 vs 0.43 ml.min.<SUP>-1</SUP> month<SUP>-1</SUP>;p<0.05), in subjects with a baseline glomerular filtration rate (GFR) of ≤ 80 ml.min<SUP>-1</SUP> followed for a median of 6.4 years. The rate of dec

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26

Tang, Shiue-Cheng. "Genetic engineering of non-beta-cells for regulated insulin secretion." Diss., Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04072004-180222/unrestricted/tang%5Fshiue-cheng%5F200312%5Fphd.pdf.

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27

Björnholm, Marie. "Molecular mechanisms of insulin action in human skeletal muscle and adipose tissue : implications for diabetes and obesity /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-245-0.

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28

Davoren, Peter M. "The role of non-esterified fatty acids in non-insulin dependent diabetes mellitus." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323655.

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29

Agalo, Faith. "Synthesis of Insulin-Regulated Aminopeptidase (IRAP) inhibitors." Thesis, Uppsala universitet, Analytisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-257559.

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The need for alternative cognitive enhancers has risen due to the fact that clinical trial results of the drugs currently approved for treating these disorders have not been satisfactory. IRAP has become a possible drug target for treating cognitive impairment brought about by Alzheimer’s disease, head trauma or cerebral ischemia, among others. This came after the revelation that Angiotensin IV enhances memory and learning. Angiotensin IV, the endogenous ligand of IRAP has been structurally modified with the aim of producing potent IRAP inhibitors. However, the peptidic nature of these inhibit

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30

Fraser, Adam. "Effects of aerobic and resistance training on insulin sensitivity, muscle composition and dietary fat intake." Access electronically, 2004. http://www.library.uow.edu.au/adt-NWU/public/adt-NWU20050330.095731/index.html.

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31

Pereira, Sandra M. "Impaired response of protein synthesis and turnover to insulin in men with type 2 diabetes mellitus : by Sandra M. Pereira." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101161.

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Although insulin resistance of glucose and fat metabolism in type 2 diabetes mellitus (T2DM) is firmly established, that of protein remains controversial for methodological reasons. A hyperinsulinemic (40MU/m2·min) euglycemic (5.5 mmol/L) isoaminoacidemic (postabsorptive concentrations) clamp was combined with [3-3H]glucose and [1-13C]leucine kinetics to concurrently assess protein and glucose metabolism in 10 hyperglycemic men with T2DM and 11 men without (all BMI=29+/-kg/m2), matched also for age, body composition, and waist circumference. In response to hyperinsulinemia, protein turnover an

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32

Simmons, Max W. "Factors affecting exercise adherence in non-insulin dependent diabetes mellitus sufferers /." Title page, contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09ARM/09arms592.pdf.

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33

Henderson, Amy Elizabeth. "Can the Consumption of Fruits Containing Anthocyanins Reduce the Risk of Developing Type 2 Diabetes?" Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/HendersonAE2007.pdf.

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34

Hutton, Stacy Lynn. "Perceptions of control and social cognitive theory understanding adherence to a diabetes treatment regimen /." Electronic thesis, 2002. http://dspace.zsr.wfu.edu/jspui/handle/10339/193.

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35

Hart, Alan William. "Engineering non-neuroendocrine cell lines to constitutively secrete fully processed insulin." Thesis, University of Aberdeen, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265894.

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Gene therapy, where non-islet cells are transduced to express insulin, encapsulated and implanted into the diabetic patient, is a possible alternative therapy for type I diabetes, which may alleviate some of the long-term complications of the disease. Insulin, however, is synthesised as a precursor, proinsulin, which is proteolytically modified by two endocrine-cell specific proteases, PC2 and PC3. Non-neuroendocrine cells do not express PC2 and PC3, but express a related protease, furin. Furin is unable to process proinsulin to insulin efficiently, so we employed PCR mutagenesis to alter the

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36

Billingham, M. S. "Lipoprotein subfraction composition in Type 2 (non-insulin dependent) diabetes mellitus." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233326.

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37

Minić, Marina. "Investigation of a syndrome of non insulin-dependent hypoglycaemia and overgrowth." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708929.

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38

Dean, John Duncan. "Lipoprotein metabolism and macrovascular disease in non-insulin dependent diabetes mellitus." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/34322.

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A case control study comparing fasting lipid and apolipoprotein concentrations in NIDDM patients and normal control subjects matched for age, sex and body mass, reveals abnormalities of high density lipoproteins and apolipoprotein B containing lipoproteins despite hypoglycaemic therapy. HDL cholesterol concentration is reduced in these NIDDM patients, whilst apolipoprotein concentrations are similar to the controls. Therefore HDL particles may be cholesterol poor, possibly reflecting reduced reverse cholesterol transport. LDL cholesterol concentration may also be reduced in these patients whil

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39

Coates, Philip A. "Assessment of beta-cell function and insulin sensitivity in established non-insulin dependent diabetes mellitus : the influence of diet and sulphonylurea therapy." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/34308.

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This thesis reports on studies validating a modification of 'minimal' model analysis of the FSIVGTT to measure insulin resistance specifically in NIDDM subjects and its use along with a mixed meal test incorporating measurement of specific insulin and proinsulin concentrations to quantify changes in beta-cell function and insulin resistance following two years of diet or sulphonylurea treatment in established NIDDM. All NIDDM subjects displayed severe beta-cell dysfunction (post-prandial insulinopenia and hyperproinsulinaemia) and insulin resistance when compared to age and sex matched normals

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40

Tada, Tomohisa. "Comparison of Three-Year Clinical Outcomes After Sirolimus-Eluting Stent Implantation Among Insulin-Treated Diabetic, Non-Insulin-Treated Diabetic, and Non-Diabetic Patients from j-Cypher Registry." Kyoto University, 2013. http://hdl.handle.net/2433/180351.

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41

Wadley, Glenn, and mikewood@deakin edu au. "Regulation of insulin signalling by exercise in skeletal muscle." Deakin University. School of Health Sciences, 2003. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050826.111050.

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Regular physical activity improves insulin action and is an effective therapy for the treatment and prevention of type 2 diabetes. However, little is known of the mechanisms by which exercise improves insulin action in muscle. These studies investigate the actions of a single bout of exercise and short-term endurance training on insulin signalling. Twenty-four hours following the completion of a single bout of endurance exercise insulin action improved, although greater enhancement of insulin action was demonstrated following the completion of endurance training, implying that cumulative bouts

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42

Cambron, Liz Doralyn. "Factors Affecting Metabolism During Non-Feeding Stages in Insects." Diss., North Dakota State University, 2020. https://hdl.handle.net/10365/31868.

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Although feeding is important for optimal development and growth in insects, there are several points during the insect life cycle that are non-feeding: metamorphosis, pupation, and overwintering. Non-feeding periods also occur in response to internal cues, such as feedback from nutrient thresholds and immune responses being activated. Additionally, as an insect goes through different developmental stages, its nutritional requirements change in response to or in preparation for non-feeding periods. Most physiological responses like feeding are regulated through an interconnection of pathways,

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43

Yamamoto, Jin Marcos, Sebastian Padro-Nuñez, Mirella Guarnizo-Poma, et al. "Association between serum transaminase levels and insulin resistance in euthyroid and non-diabetic adults: Serum transaminase levels and insulin resistance in healthy adults." Elsevier Ltd, 2020. http://hdl.handle.net/10757/652461.

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Aim: To evaluate the association between elevated serum transaminase levels and insulin resistance (IR) in a population of healthy individuals. Methods: We define IR with a cut-off point of homeostatic model assessment (HOMA-IR) ≥ 3.8. For aspartate aminotransferase (AST), we consider elevated values >30 U/L in women and values >36 U/L in men. For alanine aminotransferase (ALT), we consider elevated values >30 U/L in women and values >40 U/L in men. We performed a crude and adjusted generalized linear model from Poisson family with robust variance, in order to evaluate the association between

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44

Mörth, Corinna. "Consequences of postnatal insulin-like growth factor II overexpression in insulin-like growth factor I deficient mice." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-46307.

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45

Liu, Ensheng Yuan Jian-Min. "Sensitivity, non-equilibrium thermodynamic and control analyses of insulin metabolic signaling pathways /." Philadelphia, Pa. : Drexel University, 2007. http://hdl.handle.net/1860/1862.

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46

Winter, Aaron. "Protein metabolism and insulin resistance in non-small cell lung cancer cachexia." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97084.

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Cancer cachexia is characterized by weight loss and insulin resistance. Previous work has shown blunted protein anabolism in insulin resistant conditions. This study tested whether hyperaminoacidemia with hyperinsulinemia elicits blunted whole-body protein anabolism in cachectic non-small cell lung cancer (NSCLC). Whole-body [13C]leucine and [3H]glucose kinetics were assessed in 8 NSCLC patients and 10 age and weight-matched controls during a euglycemic, hyperinsulinemic, clamp with isoaminoacidemia (Iso-AA), followed by hyperaminoacidemia (Hyper-AA). Glucose utilization increased from Iso

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47

Alhamali, Abubaker Mohamed Zidan. "Carbohydrate composition of low density lipoprotein in non insulin dependent diabetes mellitus." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341464.

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48

Wong, Winnie Manlai. "Chinese Immigrants with Non-Insulin-Dependent Diabetes Mellitus: Nutritional Self-Management Approach." NSUWorks, 2019. https://nsuworks.nova.edu/hpd_con_stuetd/54.

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Background: Chinese immigrants (CIs) with non-insulin dependent diabetes mellitus (NIDDM) generally have poor control in their diet regimen. Due to the variation in body mass, physiology, and cultural differences as compare with the general American population, special attention must be conducted in treating diabetes in Cis, emphasizing culturally sensitive care and nutrition therapy that acknowledge the differences. Purpose: The purpose of this project was to assess cultural challenges in self-management for CIs living with non-insulin dependent diabetes mellitus and evaluate the effectivenes

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49

Katta, Anjaiah. "Lean and obese zucker rats exhibit different patterns of p70S6kinase regulation in the tibialis anterior muscle in response to high force muscle contraction." Huntington, WV : [Marshall University Libraries], 2007. http://www.marshall.edu/etd/descript.asp?ref=814.

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50

Branvold, Devon J. "Regulation of LKB1-STRAD-MO25 complex expression and activation of AMPK in skeletal muscle by thyroid hormone /." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1950.pdf.

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