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Rozprawy doktorskie na temat „Integrin modulation”

Autor: Grafiati

Data publikacji: 2 listopada 2024

Data aktualizacji: 31 lipca 2025

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1

Buttery, Robert Christians. "Integrin affinity modulation and lung cancer." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29025.

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Recent work has shown that the transmembrane protein CD98 is able to influence the affinity with which β1 integrins bind to extracellular ligands. The first part of this thesis presents confocal microscopy and co-immunoprecipitation experiments that confirm the physical juxtaposition of the two proteins within the cell membrane, suggesting a direct functional link between the two. It also demonstrated that cross-linking CD98 stimulates both phosphoinositide 3-kinase intracellular signalling and increased β1 integrin-dependent cellular adhesion. Because of the role of CD98 in integrin affinity

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Coppolino, Marc Gabriel. "Modulation of integrin function by calreticulin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ35131.pdf.

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Elliott, Paul Anthony. "Integrin affinity modulation and survival signalling." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/4393.

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Integrins are heterodimeric transmembrane proteins that provide a bi-directional link between the cell’s internal biological mechanisms and the extracellular environment. During inside-out signalling, intracellular messages converge on the integrin cytoplasmic domain to induce a conformational change. This is transmitted to the extracellular domain where it results in an alteration in affinity for integrin ligands such as fibronectin and laminin. In this way the cell has developed the ability to modulate the critical functions of adhesion and cell movement. In outside-in signalling, the integr

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Lad, Yatishkumar. "Integrin affinity modulation by Ras signalling molecules." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/24800.

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In this thesis I have sought to understand the mechanism by which H-Ras and its effectors modulate integrin affinity. H-Ras is a member of the Ras superfamily of small GTP binding proteins. Expression of the constitutively active variant of H-Ras (Ras G12V) within an integrin affinity reporter system (αβ-py cells) reduced integrin affinity (suppressed integrin). Ras effector mutants revealed that integrin suppression is mediated by Raf-dependent and Raf-independent signalling pathways. Raf-independent signalling pathways activated by Ral-GEFs and PI3-kinase were not recognisable for integrin s

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El-Aouni, Chiraz. "In Vivo modulation of integrin linked kinase using transgenic mice." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-61756.

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van, Wieringen Tijs. "Intra- and Extracellular Modulation of Integrin-directed Connective Tissue Cell Contraction." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-102349.

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All blood vessels in the microvasculature are embedded in loose connective tissue, which regulates the transport of fluid to and from tissues. The intersti-tial fluid pressure (IFP) is one of the forces that control this transport. A lowering of IFP in vivo results in an increased transport of fluid from the circulation into the underhydrated connective tissues, resulting in edema formation. During homeostasis, contractile connective tissue cells exert a tension on the connective tissue fibrous network by binding with β1 in-tegrins, thereby actively controlling IFP. During inflammation, the IF

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Walsh, Erin. "Crossreactivity of alpha9beta1 integrin with p75NTR in modulation of proinvasive activities of glioma cells." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/143048.

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Biology<br>Ph.D.<br>Gliomas are the most common and difficult to treat tumors of the central nervous system. Current treatments often fail to slow progression of disease due to the high invasive nature of glioma leading to a high percentage of recurrence. Our previous studies have demonstrated that the levels of alpha; 9 beta; 1 integrin found on high grade glioma were significantly increased in comparison to normal brain tissue where the levels were negligible. We also found that interaction between alpha; 9 beta; 1 integrin and nerve growth factor (NGF) plays a major role in progression of e

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Coyer, Sean R. "Modulation of cell adhesion strengthening by nanoscale geometries at the adhesive interface." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34763.

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Cell adhesion to extracellular matrices (ECM) is critical to many cellular processes including differentiation, proliferation, migration, and apoptosis. Alterations in adhesive mechanisms are central to the behavior of cells in pathological conditions including cancer, atherosclerosis, and defects in wound healing. Although significant progress has been made in identifying molecules involved in adhesion, the mechanisms that dictate the generation of strong adhesive forces remain poorly understood. Specifically, the role of nanoscale geometry of the adhesive interface in integrin recruitment an

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Lygoe, Kate Alexandra. "Modulation of the myofibroblast phenotype is via the interaction of extracellular matrix proteins with integrin receptors." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411053.

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Hönig, Ellena [Verfasser], та Ralf [Akademischer Betreuer] Jacob. "Modulation der β1-Integrin-Lokalisation an der apikalen Plasmamembran durch Galektin-3 / Ellena Hönig ; Betreuer: Ralf Jacob". Marburg : Philipps-Universität Marburg, 2017. http://d-nb.info/1129358348/34.

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Brown, Ashley Carson. "Modulation of pulmonary epithelial to mesenchymal transitions through control of extracellular matrix microenvironments." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44827.

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Epithelial to mesenchymal transition (EMT), the transdifferentation of an epithelial cell into a mesenchymal fibroblast, is a cellular process necessary for embryonic development and wound healing. However, uncontrolled EMT can result in accumulation of myofibroblasts and excessive deposition of ECM, contributing to the pathological progression of fibrotic diseases such as pulmonary fibrosis. The ability to control EMT is important for development of novel therapeutics for fibrotic pathologies and for designing novel biomaterials for tissue engineering applications seeking to promote EMT for

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Kamboj, Sahil. "Outils avancés pour la modulation du trafic des intégrines dans le cancer de l'ovaire." Electronic Thesis or Diss., CY Cergy Paris Université, 2024. http://www.theses.fr/2024CYUN1300.

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Les intégrines sont des récepteurs hétérodimériques de surface cellulaire qui jouent un rôle essentiel dans la gestion des interactions cellule-cellule, lesquelles influencent ensuite des processus biologiques à plusieurs échelles tels que le comportement cellulaire, le remodelage de la matrice extracellulaire et la formation des tissus. Ces processus s'étendent de quelques millisecondes à plusieurs jours. Les méthodologies existantes pour étudier la fonction des intégrines à différentes échelles biologiques - des cellules individuelles aux tissus entiers - s'avèrent souvent chroniques et manq

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Chilcoat, Clayton Douglas. "Protein Kinase A Regulates β2 Integrin Avidity Activation and Subsequent Neutrophil Activation via Modulation of Myosin Light Chain Kinase". NCSU, 2005. http://www.lib.ncsu.edu/theses/available/etd-03312005-093042/.

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β2 integrins are adhesion molecules on the surface of neutrophils. Avidity activation of β2 integrins includes transportation of pre-formed integrins to the cell surface and a conformational change in the integrin to a high-binding state. Upon binding ligand, β2 integrins initiate a signaling cascade that results in activation of the neutrophil to a pro-inflammatory state, and the inhibition of this signal can prevent further activation of the neutrophil. cAMP and it effector protein kinase A (PKA) exert a generally inhibitory effect upon neutrophil activation. PKA has been shown to inactivate

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Lidén, Åsa. "Integrin αVβ3-Directed Contraction by Connective Tissue Cells : Role in Control of Interstitial Fluid Pressure and Modulation by Bacterial Proteins". Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6601.

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<p>This thesis aimed at studying mechanisms involved in control of tissue fluid homeostasis during inflammation.</p><p>The interstitial fluid pressure (P<sub>IF</sub>) is of importance for control of tissue fluid balance. A lowering of P<sub>IF</sub> <i>in vivo</i> will result in a transport of fluid from the circulation into the tissue, leading to edema. Loose connective tissues that surround blood vessels have an intrinsic ability to take up fluid and swell. The connective tissue cells exert a tension on the fibrous network of the tissues, thereby preventing the tissues from swelling. Under

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Lionello, Valentina Maria. "Modulation of BIN1 expression rescues different forms of centronuclear myopathies in murine models." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ010.

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Les myopathies centro-nucléaires (CNM) sont un groupe de maladies musculaires sévères caractérisées par une faiblesse musculaire générale. La forme la plus sévère est la CNM liée à l’X (XLCNM), causée par des mutations de la Myotubularine (MTM1). D’autres formes autosomales existent et sont causées par des mutations de l’Amphiphysine2 (BIN1) et de la Dynamine2 (DNM2). Les mécanismes pathologiques menant aux CNMs restent à éclaircir et à ce jour aucune thérapie n’est disponible pour traiter les patients. Nous avons modulé les niveaux de protéines de MTM1, BIN1 et DNM2 dans des modèles murins de

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Asanbaeva, Anna. "Cartilage growth and remodeling modulation of growth phenotype and tensile integrity /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3223030.

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Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed September 21, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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Masi, Alessia. "Targeting integrins and modulating invasion and metastasis with metal-based drugs." Doctoral thesis, Università degli studi di Trieste, 2010. http://hdl.handle.net/10077/3615.

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2008/2009<br>Distant metastases of solid tumours are the major cause of cancer death. To improve the effectiveness of chemotherapy, only marginally active on secondary tumours, anti-metastatic agents are needed, i.e. compounds that display the capacity to selectively interfere with metastatic formation and growth. Among metal compounds, NAMI-A, HIm[Ru(III)Cl4Imdmso], has repeatedly shown a peculiar and selective anti-metastatic activity being able to prevent the formation, and to inhibit the growth of established secondary tumours. On these bases, the first phase of the project was aimed to in

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Tupet-Defrance, Armelle. "Modulation de la fonctionnalité des integrines par les rayonnements ultraviolets A dans les fibroblastes du derme humain." Paris 7, 1999. http://www.theses.fr/1999PA077240.

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Pellegrino, Emilie. "Impact de Saccharomyces boulardii sur la restitution intestinale par modulations des molécules d'adhérences." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4702.

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Les patients atteints de MICI (maladie de Crohn et recto-colite hémorragique) présentent souvent des lésions des cellules de l'épithélium intestinal. La rémission de ces maladies nécessite à la fois un arrêt de l'inflammation et une migration des entérocytes pour réparer les dommages épithéliaux. Cette migration cellulaire appelée restitution intestinale requiert des adhérences cellule-MEC et cellule-cellule réalisées par les complexes protéiques associés aux intégrines et cadhérines. Le but de cette thèse a été d'étudier l'impact deSaccharomyces boulardii (Sb) sur la réparation de l'épithéliu

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Schmidt, Katja [Verfasser]. "Cellular factors modulating the entry efficiency of West Nile virus – Involvement of integrins / Katja Schmidt." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2012. http://d-nb.info/1024516601/34.

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Thacker, Robert I. "Modulation of Human Dendritic Cell Activity by Adsorbed Fibrin(ogen)." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1218553202.

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Gray, Matthew Alan. "A comparative analysis of proportional-integral compensated shunt active power filters." Master's thesis, Mississippi State : Mississippi State University, 2004. http://library.msstate.edu/etd/show.asp?etd=etd-11092004-083404.

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Jain, Priyesh. "Design and Synthesis of Beta-Hairpin Peptidomimetics for Modulating Integrin Mediated Cell Adhesion, Abeta Fibrillogenesis and p53-MDM2 Protein-Protein Interactions." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3458.

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Inhibiting therapeutically important protein-protein interactions has been a tremendous challenge for medicinal chemists. The folded 3D structures of peptides and proteins, mainly comprise secondary structural elements i.e α-helices and β-sheet have created an opportunity to design small molecules and peptidomimetic inhibitors of protein-protein interaction (PPI). Hence, information about the formation and stabilization of these secondary structures is vital for designing future drugs. In this dissertation, several cyclic beta-hairpin peptidomimetics that mimic the recognition surface have bee

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GUTIERREZ-MARTINEZ, CELSO. "Multiplexage par modulation de coherence en optique integree sur niobate de lithium (linbo3); etude et realisation de modulateurs rapides de coherence." Besançon, 1994. http://www.theses.fr/1994BESA2006.

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Cette these se situe dans le cadre general des travaux concernant le multiplexage optique par modulation de coherence. Cette technique repose sur le codage de signaux d'information sur des retards optiques entre les paquets d'onde emis par des sources optiques a faible longueur de coherence. Le multiplexage par modulation de coherence se presente comme une alternative potentielle parmi l'ensemble des techniques de multiplexage optique. Le but de cette these est de montrer la faisabilite de cette technique de multiplexage en technologie d'optique integree sur niobate de lithium (linbo3). Cette

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Belkadi, Djilali. "Contribution à la modélisation et à la simulation des circuits intégrés analogiques : application aux systèmes échantillonnés et aux circuits linéaires de haute fréquence." Grenoble INPG, 1997. http://www.theses.fr/1997INPG0062.

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Ce travail est une contribution a la modelisation et la simulation temporelle des circuits integres analogiques. Suite au besoin de la conception descendante et aux limites de la simulation electrique, la conception sur differents niveaux d'abstraction est devenue necessaire. Puisque les circuits integres analogiques sont divers, nous en avons choisi deux types : les systemes echantillonnes et les circuits lineaires de haute frequence. Dans le premier genre, une methode de simulation est proposee. Elle est basee sur la linearisation du circuit par phase d'horloge et la resolution analytique de

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Maury, Ghislaine. "Mélange de signaux microondes par voie optique." Grenoble INPG, 1998. http://www.theses.fr/1998INPG0152.

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Nous avons etudie une solution originale de melange de signaux microondes par voie optique. Elle est fondee sur la conversion par un interferometre de la modulation de frequence de la lumiere, issue de la modulation directe d'une diode laser, en modulation d'intensite. L'interferometre etant un dispositif passif, cette technique presente plusieurs avantages par rapport aux techniques classiques necessitant des modulateurs actifs : elle peut etre facilement inseree dans un systeme de communications optiques avec multiplexage en longueurs d'onde, les pertes de conversion sont plus faibles, et en

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Hudson, Robert Dearn. "Development of an integrated co-processor based power electronic drive / by Robert D. Hudson." Thesis, North-West University, 2008. http://hdl.handle.net/10394/3723.

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The McTronX research group at the North-West University is currently researching self-sensing techniques for Active Magnetic Bearings (AMB). The research is part of an ongoing effort to expand the knowledge base on AMBs in the School of Electrical, Electronic and Computer Engineering to support industries that make use of the technology. The aim of this project is to develop an integrated co-processor based power electronic drive with the emphasis placed on the ability of the co-processor to execute AMB self-sensing algorithms. The two primary techniques for implementing self-sensing in AMBs

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Ghassoul, M. "Organ preservation with spectral analysis testing based on a microprocessor : Preservation and testing isolated rat heart using a microcomputer on-line analysing the electrocadiogram using integral pulse frequency modulation." Thesis, University of Bradford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374904.

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Sanchez, Perez Célia. "Dispositifs optiques intègrés hybrides, verre / polymère électro-optique : applicationà un polariseur et à un modulateur de phase." Grenoble INPG, 2000. http://www.theses.fr/2000INPG0159.

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La generalisation actuelle des echanges d'information a conduit a une croissance des besoins en bande passante des systemes de telecommunication. Le traitement tout optique de l'information est devenu necessaire generant un besoin accru des dispositifs optiques pour stocker, controler et traiter d'importantes quantites d'informations. Dans le domaine de telecommunications, l'effet electro-optique des differents materiaux est souvent utilise pour la realisation des composants. Les materiaux organiques offrent de nouvelles perspectives pour le developpement de dispositifs electro-optiques perfor

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Hayek, Dayana [Verfasser], Agnes [Akademischer Betreuer] Flöel, Alfons [Akademischer Betreuer] Hamm, et al. "Association of cognitive performance with hippocampal network integrity of healthy adults and its modulation through non-invasive brain stimulation / Dayana Hayek ; Gutachter: Agnes Flöel, Alfons Hamm, Martin Lotze, Michael Nitsche ; Agnes Flöel, Alfons Hamm." Greifswald : Universität Greifswald, 2019. http://d-nb.info/1193177782/34.

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Hayek, Dayana [Verfasser], Agnes [Akademischer Betreuer] Flöel, Alfons [Akademischer Betreuer] Hamm, et al. "Association of cognitive performance with hippocampal network integrity of healthy adults and its modulation through non-invasive brain stimulation / Dayana Hayek ; Gutachter: Agnes Flöel, Alfons Hamm, Martin Lotze, Michael Nitsche ; Agnes Flöel, Alfons Hamm." Greifswald : Universität Greifswald, 2019. http://nbn-resolving.de/urn:nbn:de:gbv:9-opus-29229.

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Bariteau, Jean-Marc. "Etude et réalisation d'anneaux résonnants en optique intégrée." Grenoble INPG, 1989. http://www.theses.fr/1989INPG0068.

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La technologie optique integree sur substrat silicium permet la realisation d'un microguide d'ondes en anneau couple a des microguides rectilignes formant ainsi une cavite resonante. Cette etude apporte des solutions theoriques et de premiers resultats experimentaux pour cet interferometre integre. Une presentation des resonances observables par interferences a ondes multiples est donnee puis l'influence des divers parametres sur les pics de resonance est etudiee. Une evaluation des pertes dues a la courbure de ces microguides est effectuee et le couplage entre microguides est calcule par la m

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AUTIER, PHILIPPE. "Gravure ionique reactive des semiconducteurs iii-v avec controle in situ par interferometrie laser : applications a l'optique integree." Paris 6, 1989. http://www.theses.fr/1989PA066018.

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Cette these est une contribution a l'etude de la gravure ionique reactive (rie) des semiconducteurs iii-v en plasmas chlores cl#2/ch#4/h#2/ar. Une analyse in situ de la surface gravee a ete mise en uvre par une methode d'interferometrie laser sur des motifs de test constitues de reseaux. Les parametres caracteristiques de la surface gravee sont alors accessibles en temps reel. La rie offre un outil pour les applications a l'optique integree: realisation de dispositifs passifs (guides a faibles pertes, miroirs ou virages) et de dispositifs actifs (commutateurs, modulateurs, detecteurs, etc. ).

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Boothe, Patricia. "Muc4, the Integral Membrane Modulator of ErbB2: The Effects of Muc4 Expression on ErbB2 and ErbB3 Phosphorylation, Receptor Levels and Sub-Cellular Localization In Breast Cancer Cells Treated With Neuregulin." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/670.

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Muc4, a heterodimeric transmembrane mucin containing EGF-like domains, has been described as an ErbB2-binding protein which modulates signaling via the ErbB2-ErbB3 pathway. In Muc4-transfected MCF-7 cells, Muc4 expression resulted in alteration of both the time course and phosphorylation levels of NRG beta 1 induced phosphorylation and activation of both ErbB2 and ErbB3. Muc4 significantly enhanced the autophosphorylation of ErbB2 over the early (defined 0-30 min) and intermediate (30-120 min) NRG beta 1 treatment times at three sites, Y1248, Y1221 and Y1139. The sites displayed differential m

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ABAHAMID, ABDELOUAHAB. "Adaptation de cellules d'euglena gracilis au pentachlorophenol et au cadmium : modulations de l'expression de proteines de stress et d'enzymes de detoxication apparentees aux cytochromes p-450 (doctorat : structure et fonctionnement des systemes biologiques integres)." Paris 11, 1998. http://www.theses.fr/1998PA114825.

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Lestra, Alexis. "Contribution à l'étude de composants intégrés de type laser/modulateur pour transmissions optiques à haut débit." Grenoble INPG, 1996. http://www.theses.fr/1996INPG0142.

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Les liaisons optiques a une longueur d'onde de 1,55 micrometres necessitent des sources a faible fluctuations de frequences. Un laser de type dfb integre avec un modulateur externe a electro-absorption est un composant-cle pour ces transmissions. La section laser, utilisee en continu, doit constituer une source monomode a forte puissance. La modulation externe peut etre obtenue par effet stark confine au moyen d'un ruban haut debit de type v-loaded stripe ou ridge. Les deux sections sont integrees par couplage direct ; une methodologie est mise en oeuvre pour analyser la qualite de la zone de

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Faderl, Ingo. "Étude et réalisation d'un modulateur électro-optique utilisant des polymères non linéaires dans un circuit optique intégré sur silicium." Grenoble INPG, 1994. http://www.theses.fr/1994INPG0102.

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La these demontre la faisabilite d'un modulateur electro-optique avec des polymeres non lineaires en optique integree sur silicium. Le modulateur est base sur un interferometre de mach-zehnder. L'originalite de ce travail repose sur l'hybridation d'un polymere non-lineaire sur un circuit optique integre passif. Seuls les guides actifs sont fabriques avec des polymeres non-lineaires. Le reste du modulateur est fabrique a l'aide de nitrure de silicium et de silice. Le premier chapitre rappelle les principes de l'optique non-lineaire avec les polymeres. La birefringence, l'absorption, le decalage

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De, Simone Mariarosaria. "Modulation of integrin activity for diagnostic and therapeutic applications." Tesi di dottorato, 2010. http://www.fedoa.unina.it/8209/1/de_simone_mariarosaria_23.pdf.

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SUMMARY Over the past decade, the scientific research spent many efforts to develop therapeutic and diagnostic systems able to contact selectively the target cells and to minimize their diffusion in healthy organs. For this purpose the most diffuse approach was targeting the molecular markers overexpressed on the tissues of interest. In this contest, the integrin family of cell adhesion receptors was one of the most studied markers. (Tucker G.C., 2006). In particular, among all integrins, v3 receptor was particularly studied in the last decade. Physiologically, it mediates many differen

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Tsai, Cheng-Hsien, and 蔡承憲. "Electric field modulation of integrin polarization and directed cell migration." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/19132907775205069771.

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碩士<br>國立臺灣大學<br>醫學工程學研究所<br>99<br>Electrical stimulation is clinically used for the treatment of pain and to promote wound healing. In orthopaedic practices, applied electric fields (EFs) promote bone healing and improve lapine ligament repair in vivo. In the current study, several stimulation waveforms used in physical therapy were adapted to examine their effects on anterior cruciate ligament fibroblast (ACLF) migration and morphology. Most of the waveforms we tested resulted in enhanced fibroblast migration, while their effects on migration directionality were noticeably different. Furtherm

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Aouni, Chiraz el [Verfasser]. "In vivo modulation of integrin linked kinase using transgenic mice / by Chiraz El-Aouni." 2006. http://d-nb.info/982538030/34.

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Burzer, Klaus. "Modulation der Expression von Integrin-Beta4, Interleukin-1Beta und HMGA in humanen kolorektalen Karzinomzellen durch Butyrat." Doctoral thesis, 2003. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-7840.

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Das kolorektale Karzinom ist das zweithäufigste Karzinom in der westlichen Welt. Schutz bieten Ballaststoffe, die zu kurzkettigen Fettsäuren, wie zum Beispiel Butyrat, fermentiert werden. Wir konnten mittels Western Blot eine Verringerung der Genexpression der Proteine Integrin-ß4 (Zelladhäsionsfaktor), Interleukin-1ß (Entzündungsfaktor) und HMGA (Transkriptionsfaktor) ab 48 Stunden Inkubationszeit mit 2mmol/l Butyrat in der gut-differenzierten HT-29-, der entdifferenzierten SW-480-Kolonadenokarzinomzelllinie sowie deren Metastasenzelllinie SW-620 zeigen. Unsere Ergebnisse weisen darauf hin, d

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Burzer, Klaus [Verfasser]. "Modulation der Expression von Integrin-β4 [Integrin-Beta-4], Interleukin-1β [Interleukin-1-Beta] und HMGA in humanen kolorektalen Karzinomzellen durch Butyrat / vorgelegt von Klaus Burzer". 2004. http://d-nb.info/970170297/34.

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Driver, Glenn Alan. "Integrin-linked Kinase (ILK) expression in moderately differentiated human oesophageal squamous carcinoma cell lines: A growth factor modulation, activity and link to adhesion." Thesis, 2008. http://hdl.handle.net/10539/4842.

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Abstract Integrin-linked Kinase (ILK) is an integrin-associated protein kinase, which regulates growth factor-signalling pathways and cell-ECM adhesion events. Abrogated ILK expression or activity has been implicated in contributing to oncogenic transformation. We examined the role played by ILK in growth factor-stimulated and integrin signalling events in five human oesophageal squamous cell carcinoma cell lines (HOSCCs), known to overexpress the EGF receptor. Western blot analysis revealed the presence of ILK (59kDa) in all the moderately differentiated HOSCC lines. ILK1 was confirmed as be

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Chilcoat, Clayton D. "Protein kinase A regulates B2 integrin avidity activation and subsequent neutrophil activation via modulation of myosin light chain kinase." 2004. http://www.lib.ncsu.edu/theses/available/etd-03312005-093042/unrestricted/etd.pdf.

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Straube, Kathleen. "Modulation von Differenzierungsprozessen in der Mundschleimhaut (Maus) durch Inhibition des epidermalen Wachstumsfaktor-Rezeptors (EGFR): Immunhistochemische Untersuchungen." Doctoral thesis, 2017. https://ul.qucosa.de/id/qucosa%3A16728.

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Die strahleninduzierte Mucositis enoralis ist eine der bedeutendsten und häufig dosislimitierenden frühen Nebenwirkungen der Strahlentherapie fortgeschrittener Kopf Hals Tumoren. Bis heute hat sich noch kein allgemein gültiges Konzept zur Therapie und Prophylaxe der Mundschleimhautentzündung durchsetzen können. Ein Ansatz zur selektiven, auf der Tumorbiologie beruhenden Beeinflussung der Strahlenempfindlichkeit von Tumoren ist die Blockade des epidermalen Wachstumsfaktor-Rezeptors (EGFR). In Kombination mit Strahlentherapie sollen so die lokale Tumorkontrolle und die Heilungschancen verbessert

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Si-YenLiu and 劉思顏. "The role of redox modulation in very late antigen-4 integrin mediated leukocyte activation and toluene diisocyanate induced airway inflammation." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/18598603745207550572.

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博士<br>國立成功大學<br>基礎醫學研究所<br>98<br>The trafficking of leukocytes from the blood into peripheral tissues through a multiple-step intercellular adhesion process is essential for selective recruitment of leukocytes to the inflammation sites. Like other immune reactions, a central question regarding the initiation and progression of allergic inflammation which leads to diseases like asthma is how cells responsible for stimulations are selectively recruited to the airway. We suggest that reactive oxygen species in the tissue microenvironments may participate in the regulation of immune responses by

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Marotta, Anthony. "Dysregulation of integrin-linked kinase (ILK) signaling during colorectal carcinogenesis : modulation of signaling pathways by non-steroidal anti-inflammatory drugs (NSAID)." Thesis, 2002. http://hdl.handle.net/2429/13101.

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One of the most common events involved in the development of human colon cancer is the mutation of the adenomatous polyposis coli (APC) gene. This protein through its interactions with Axin and GSK3β, serves to regulate the cytosolic levels of β-catenin. Mutation of the APC gene, which impairs complex formation, results in the stabilization of β-catenin. Stabilization is believed to coincide with the translocation of β-catenin to the nucleus, where it up-regulates a number of genes implicated in oncogenesis. Interestingly, stable over-expression of the integrin-linked kinase (ILK) in ra

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Li, Mark. "Elucidating the Effects of Integrin-linked Kinase Modulation on Sarco/endoplasmic Reticulum Calcium ATPase Function in Human Induced Pluripotent Stem Cell-derived Cardiomyocytes." Thesis, 2013. http://hdl.handle.net/1807/43078.

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Integrin-linked kinase (ILK) is an important mechanoreceptor that mediates many cellular signaling pathways. Its dysregulation causes dilated cardiomyopathy and other complications in the heart. Restoration of ILK improves cardiac function and survival, but the exact mechanism is unknown. Recent studies in our lab suggest that the cardioprotective properties of ILK may be related to its regulation of sarco/endoplasmic reticulum calcium ATPase (SERCA2a). The protein expressions of ILK and SERCA2a are positively correlated based on adenoviral transduction of ILK and siRNA targeting ILK in hu

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Ifergan, Igal. "Modulation de la réponse immunitaire dans le cerveau par la barrière hémato-encéphalique : implication en sclérose en plaques." Thèse, 2011. http://hdl.handle.net/1866/7042.

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La sclérose en plaques (SEP) est une maladie inflammatoire du système nerveux central (SNC) caractérisée par une infiltration périvasculaire de cellules mononucléaires, telles que les lymphocytes T CD4+ et CD8+, les lymphocytes B ainsi que les cellules myéloïdes qui comprend les monocytes, les macrophages et les cellules dendritiques (DCs). Ce phénomène d’infiltration est dû à une fragilisation de la barrière hémato-encéphalique (BHE). L’entrée des cellules immunitaires au SNC va mener à la destruction de la gaine de myéline et donc à l’apparition de plaques de démyélinisation. Ainsi, nous avo

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Teng, Hsun Yang, and 鄧勳陽. "A Compressed Sensing based Procedure Incorporating the Integral Pulse Frequency Modulation (IPFM) Model for Heart Rate Variability (HRV) Spectral Estimation." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/07424272295241688545.

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碩士<br>長庚大學<br>電子工程學系<br>101<br>Previous studies in literature have shown that Heart Rate Variability (HRV) can serve as a noninvasive for assessing autonomic control activities. Among HRV analysis technique, the Integral Pulse Frequency Modulation (IPFM) model is described as a functional mechanics for the cardiac pacemaker and generate a series of heartbeats. In this thesis, a Compressed Sensing (CS) based procedure incorporating the IPFM Model for HRV spectral estimation is proposed. Different from the traditional sampling theory, the theory of CS can be possibly reconstructed almost the sam

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