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Rozprawy doktorskie na temat „Interleukin-6”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Schebesta, Kathrin [Verfasser]. "Das Endothel sezerniert Interleukin-6 (IL-6) und stimuliert die adrenale Interleukin-6 und Aldosteronsynthese über einen Interleukin-6 unabhängigen Mechanismus / Kathrin Schebesta." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1079652612/34.

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OBAFEMI, TOLULOPE FESAYO. "THE EFFECTS OF INTERLEUKIN 6 AND INTERLEUKIN 10 ON FRAILTY IN C57BL/6 MICE." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/613394.

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Studies have shown that pro-inflammatory IL-6 and anti-inflammatory IL-10 interleukins may correlate to frailty and aging. This frailty can be defined in the context of clinical symptoms which include sarcopenia and osteoporosis, decreased activity level; or in the context of increased susceptibility to adverse health outcomes from a deficient immune system. In this experiment we tested a cohort of conditionally regulated IL-6 and IL-10 mice with controls (IL-6tg+.rtTA(r/r) (n=8), IL-10(-/-). IL-10tg+ rtTA(r/r) (n=10) and rtTA(r/r) (n=5)) under frailty assessments and immunological cell analys

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3

Terry, Catherine. "Genetic control of Interleukin-6 gene." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342452.

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Höschen-Lihs, Jutta. "Interleukin-6- und Interleukin-2-Rezeptor als Aktivitätsmarker bei infektiöser Endokarditis." [S.l.] : [s.n.], 2005. http://archiv.ub.uni-marburg.de/diss/z2005/0327/.

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Siegmund, Annette. "Interleukin-11 - analog zu Interleukin-6 - ein direkter Modulator der Nebennierenrinde." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-83542.

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6

Desallais, Lucille. "Immunisation active à base de peptides, dérivés de l’IL-6 et de l’IL-1β, dans les maladies inflammatoires chroniques". Thesis, Paris, CNAM, 2013. http://www.theses.fr/2013CNAM0867.

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Les anticorps monoclonaux anti-cytokine ont constitué une révolution dans le traitement des maladies inflammatoires chroniques, mais leur utilisation présente des inconvénients (non réponse, résistance, effets secondaires, coûts élevés).Notre équipe développe une stratégie alternative originale, l’immunisation active à base de peptides de cytokines. Elle a pour but de faire synthétiser, par l’organisme même du patient, des anticorps neutralisant les effets pathogènes dus à l’excès de cytokines.Durant ma thèse, j’ai montré que l’immunisation active contre un peptide dérivé de l’IL-6 murine est

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7

Walter, Claudia. "Bestimmung der Zytokine Interleukin-1ra, Interleukin-6, Interleukin-10 und Interleukin-12 im Vaginalsekret bei Frauen mit Bakterieller Vaginose." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-28461.

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8

Slawik, Helen Christina. "Kontinuierliche Überexpression von Interleukin-6 im Zentralnervensystem lokale Applikation des Designerzytokins Hyper-Interleukin-6 im adulten Organismus der Ratte und Auswirkungen von exzitatorischen Neurotoxinen im Interleukin-6-transgenen Mausmodell /." [S.l.] : [s.n.], 2003. http://www.freidok.uni-freiburg.de/volltexte/842.

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Gopinathan, Ganga. "The effects of interleukin-6 on angiogenesis." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8186.

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Elevated levels of the inflammatory cytokine interleukin-6, IL-6, have been linked with poor prognosis in ovarian cancer patients by influencing tumour growth, invasion, angiogenesis and chemo-resistance. A clinical trial conducted in parallel with pre-clinical studies showed an anti-IL-6 antibody to have some activity in ovarian cancer patients and in xenograft models, via reduction in pro-inflammatory and angiogenic factors such as TNF-α, IL-8 and VEGF. Anti-IL-6 treatment also showed significant reductions in vascular area with decreased expression of an angiogenic factor Jagged1. The aim o

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10

Sonnenberg, Sabine. "Tissue specific genetic regulation of Interleukin 6." Thesis, University of Southampton, 2009. https://eprints.soton.ac.uk/72590/.

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Interleukin 6 (IL6) is associated with arterial disease development, progression and surgical outcome. Raised levels of IL6 may play a causal role in disease development or may be the effect of pathology. An IL6 single nucleotide polymorphism (SNP) G- 174C has been identified and reported to associate with IL6 expression. However, conflicting results have emerged and both the relationship between IL6 and vascular disease and the precise effect of SNP G-174C in vivo in humans remains obscure. The aim of this study was to establish the effect of SNP G-174C in humans, in vivo in different tissues

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11

McIlmoil, Stephen. "Regulation of adrenal steroidogenesis by interleukin-6 /." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1976.pdf.

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McIlmoil, Stephen A. "Regulation of Adrenal Steroidogenesis by Interleukin-6." BYU ScholarsArchive, 2007. https://scholarsarchive.byu.edu/etd/975.

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Cortisol and dehydroepiandrosterone (DHEA) are steroids produced by the zona fasciculata (ZF) and reticularis (ZR), respectively, of the adrenal cortex. Both steroids are upregulated in response to adrenocorticotropic hormone (ACTH). Cortisol is a glucorticoid that is important in the regulation of inflammation and metabolism. DHEA is an adrenal androgen important in fetal growth and puberty but tends to decrease gradually after puberty in both men and women. DHEA has various effects on metabolism and immune function including inhibiting the effects of cortisol on some tissues. During the acut

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13

Benrick, Anna. "Cytokines in metabolic functions /." Göteborg : Section of Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, 2008. http://hdl.handle.net/2077/9608.

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14

Poe, Shaunta D. "Autocrine Effects of Catecholamines on Macrophage Release of Interleukin-6 (IL-6)." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1786.

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15

Leppert, Kyle McDonald McMurray Robert G. "The effect of glycogen depletion on responses of interleukin-1beta, interleukin-6, and interleukin-10 to maximal exercise." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2599.

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Thesis (M.A.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Oct. 5, 2009). "... in partial fulfillment of the requirement for the degree of Master of Arts in the Department of Exercise and Sport Science Exercise Physiology." Discipline: Exercise and Sports Science; Department/School: Exercise and Sport Science.

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16

Rau, Stefanie Maria. "Sepsis beim Hund: Interleukin-6 als prognostischer Parameter." Diss., [S.l.] : [s.n.], 2007. http://edoc.ub.uni-muenchen.de/archive/00007442.

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17

Wong, Pui-man Molly. "Hoxb3 mutation leads to interleukin-6 dependent plasmacytoma." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B3753564X.

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Wong, Pui-man Molly, and 黃佩文. "Hoxb3 mutation leads to interleukin-6 dependent plasmacytoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38695327.

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19

Bailey, Louise Lyn. "The development of Interleukin-6 specific peptide antagonists." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299390.

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20

Gineste, Aurélie. "Fer et immunité innée : vers une meilleure compréhension des mécanismes développés par l'hôte pour réduire le fer accessible aux pathogènes." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30117/document.

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Le fer est un élément essentiel à de nombreux processus physiologiques fondamentaux. Lors d'une infection, une forte compétition entre l'hôte et l'agent pathogène a lieu ; alors que la bactérie a besoin d'acquérir le fer de l'hôte, pour son développement et sa virulence, l'hôte déploie de nombreux mécanismes pour protéger ses stocks de fer. Il sécrète notamment un peptide capable de moduler l'homéostasie du fer au niveau systémique, l'hepcidine, qui va causer une diminution de la quantité de fer sérique, une rétention intracellulaire du fer et donc une restriction du fer accessible aux pathogè

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21

Woolley, Jane Alison. "The production, assessment and application of antibodies to human interleukin-6 (IL-6)." Thesis, Queen Mary, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338809.

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22

Schmid, Birgit. "Regulation of the human oxytocin receptor gene by interleukin-1ß and interleukin-6 in vitro." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0012/MQ59875.pdf.

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Björnstedt, Bennermo Marie. "On the genetic variation of interleukin-6 in health and coronary heart disesase /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-253-5/.

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24

Azbil, Tatiana. "Nachweis von Candida-Spezies und Bestimmung der Zytokine Interleukin-1 beta, Interleukin-1ra, Interleukin-4, Interleukin-6, Interleukin-8, Interleukin-10 und Interleukin-12 im Vaginalsekret und im Serum bei Schwangeren in Relation zum Gestationsalter." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-57576.

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25

Harré, Eva-Maria. "Die Rolle von Interleukin-6 (IL-6) in der zentralnervös vermittelten Fieberentstehung der Ratte." Wettenberg : VVB Laufersweiler, 2003. http://deposit.d-nb.de/cgi-bin/dokserv?idn=968960545.

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26

Hamzic, Namik. "The Role of Interleukin-6 in the Febrile Response." Doctoral thesis, Linköpings universitet, Cellbiologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-87453.

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Everyone who has been exposed to influenza or a bacterial infection knows how it feels to be sick. Apart from not being willing to participate in social activities, losing your appetite and experiencing pain, you have also most likely suffered from increased body temperature which defines fever, one of the most prominent signs of an acute ongoing infection. Invading the body, the infectious microorganisms are combated by the activated innate and adaptive immune systems, and the impaired balance is thus restored. While fever is an event that is controlled by the central nervous system, it has f

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27

Bußmeyer, Ingo [Verfasser]. "Struktur und Funktion von viralem Interleukin-6 / Ingo Bußmeyer." Kiel : Universitätsbibliothek Kiel, 2008. http://d-nb.info/1019669802/34.

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Voyle, Roger Bruce. "Mechanisms of intracellular and extracellular cytokine production from the human leukaemia inhibitory factor gene." Title page, contents and summary only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phv975.pdf.

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Addendum attached to back facing leaves. Includes bibliographical references (leaves 172-199). The findings establish leukemia inhibitory factor, and possibly oncostatin M, as new members of a small but growing class of cytokines produced in an intracellularly active form and also suggest that the production of alternate transcripts and intercellularly-retained proteins may be a common and important feature of cytokines of the IL-6 and other families.

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29

Kampshoff, Jörg. "Die Wirkung der Interleukine 4, 10 und 13 auf die Koinkubation von Endothelzellen und mononukleären Zellen, gemessen an der Freisetzung von PDGF, Interleukin-1-[beta] [Interleukin-1-beta] und Interleukin-6." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972057684.

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30

Hu, Yuli. "Compounds that Inhibit Cytokine-Induced Interleukin-6 Expression in a Monocytic Cell Line." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1420708103.

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31

Hauk, Thomas. "Einfluss von Makrophagen und IL-6 auf die axonale Regeneration bei der adulten Ratte." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-65621.

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Asbagh, Layka Abbasi Doymaz Fuat. "Investigating the role of zoledronic acid on interleukin-6 cytokine expression in prostate cancer cell lines/." [s.l.]: [s.n.], 2006. http://library.iyte.edu.tr/tezlerengelli/master/biyoteknoloji/T000552.pdf.

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Knuth, Berenice Scaletzky. "Prevalência de depressão e níveis séricos de IL-6, em pacientes em hemodiálise." Universidade Catolica de Pelotas, 2012. http://tede.ucpel.edu.br:8080/jspui/handle/tede/283.

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Made available in DSpace on 2016-03-22T17:27:00Z (GMT). No. of bitstreams: 1 bere.pdf: 472003 bytes, checksum: 24fe342b360c117b2eb9ab787fef47c4 (MD5) Previous issue date: 2012-02-29<br>BACKGROUND: In hemodialysis patients, depression appears as the most common psychopathological condition. States of advanced chronic kidney disease and dialysis are associated with a state of chronic inflammation. Depression has been linked to activation of the immune system characterized by high levels of pro-inflammatory cytokines. In this study we investigated the possible correlations between depression, a

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34

Kirschmer, Stefanie [Verfasser]. "Untersuchung der potentiellen Biomarker Picalm, Interleukin-1beta, Interleukin-6, Interleukin-8 und Tumor-Nekrose-Faktor alpha im Liquor von Alzheimerpatienten / Stefanie Kirschmer." Ulm : Universität Ulm. Medizinische Fakultät, 2014. http://d-nb.info/104956149X/34.

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O'Brien, John D. "The Effect of Small Organic Compounds on Triple Negative Breast Cancer Cells." Ohio University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1344436677.

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Wang, Chun-Wei. "Quantitative protein detection in serum samples using fiber-optic biosensors." Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008m/wang.pdf.

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Loung, Le Anh. "Genetic variations in the interleukin-6(IL-6) gene : implication in coronary heart disease (CHD)." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406589.

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38

Bradaric, Christian. "Interaktion coxsackieviraler Proteasen mit dem kardioprotektiven Interleukin-6-Typ-Signaltransduktionsweg." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=978987195.

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39

Kalai, Michaël. "Structure-function analysis of human interleukin-6 and its receptor." Doctoral thesis, Universite Libre de Bruxelles, 1996. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212341.

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40

Becker, Karin Beate [Verfasser]. "Das Interleukin 6-System bei Alzheimer Demenz / Karin Beate Becker." Bonn : Universitäts- und Landesbibliothek Bonn, 2012. http://d-nb.info/1043509836/34.

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41

Laumen, Susanne [Verfasser]. "Die Expression von Interleukin-6 während der Frakturheilung / Susanne Laumen." Ulm : Universität Ulm. Medizinische Fakultät, 2014. http://d-nb.info/1046890093/34.

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42

Riethmüller, Steffen [Verfasser]. "Die Entstehung des humanen löslichen Interleukin-6 Rezeptors / Steffen Riethmüller." Kiel : Universitätsbibliothek Kiel, 2016. http://d-nb.info/1118499859/34.

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Reddy, Bindu. "Interleukin-6 Levels in Generalized and Localized Aggressive Periodontitis Patients." VCU Scholars Compass, 2004. http://scholarscompass.vcu.edu/etd/1284.

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AbstractINTERLEUKIN-6 LEVELS IN GENERALIZED AND LOCALIZED AGGRESSIVE PERIODONTITIS PATIENTSBy Bindu Reddy, D.D.S.A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at the Virginia Commonwealth UniversityVirginia Commonwealth University, 2004Major Director: Joseph V. Califano, D.D.S., Ph.D.Associate Professor, Department of Periodontics Periodontitis is an inflammatory disease involving the supporting structures of the dentition. Many studies have shown that there is a relationship between periodontal disease, the presence of pro-inflammatory cyto

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44

Al-Tae, Firas. "Biology of interleukin-6 production by human natural killer cells." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/8573/.

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NK cells secrete a variety of immune-regulatory cytokines and chemokines such as interferon - γ (IFN-γ) and tumour necrosis factor- α (TNF-α). However, in some of infections where NK cells have an important role in the defence mechanism, IL-6 appears to play a significant anti-viral role. Considering the role of both IL-6 and NK cells in these infections raises the possibility that IL-6 secretion by NK cells could be a main defence mechanism against them. Morover, NK cell-mediated IL-6 secretion may provide a critical link between the innate and adaptive immune response of the host. Furthermor

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45

Ravi, Arjun Kumar. "Macrophages, monocytes and interleukin-6 in chronic obstructive pulmonary disease." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/macrophages-monocytes-and-interleukin6-in-chronic-obstructive-pulmonary-disease(806db259-02de-4d50-8c2e-5b57cb2425c0).html.

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Background: COPD is associated with an increased lung macrophage burden. Whilst lung macrophages may self-renew, recruitment of peripheral blood monocytes from the systemic circulation is considered to represent their principal means of replenishment. Through modulating expression of monocytic chemokines CCL2/CCL3 and their respective receptors (CCR2/CCR1+CCR5), IL-6 could play a key role in facilitating the recruitment of monocytes to the lungs of COPD patients. COPD is associated with enhanced pulmonary and systemic IL-6 levels; concentrations of the soluble IL-6 receptor sIL-6R may be an im

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46

Wendland, Sylke [Verfasser]. "Interleukin-6-, Interleukin-10- und TNF-alpha-Plasmaspiegel bei Patienten mit transplantations-assoziierter lymphoproliferativer Erkrankung / Sylke Wendland." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1035406365/34.

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Nitz, Rebecca [Verfasser], and Jürgen [Gutachter] Scheller. "Unterschiede in der proteolytischen Spaltung von Interleukin-6- und Interleukin-11-Rezeptor / Rebecca Nitz ; Gutachter: Jürgen Scheller." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1121745717/34.

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Schlichting, Nadine. "Palmitat induzierte Expression von IL-6 und MCP-1 in humanen Detrusormyozyten vs. bakteriell induzierter Entzündungsreaktion - ein möglicher Zusammenhang zwischen diabetischen Stoffwechsel und Infektionen der Harnblase." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-67731.

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Adipöse Patienten und Typ-2-Diabetiker zeigen ein erhöhtes Risiko für Harnwegsinfekte. Die Ursache der höheren Prävalenz ist noch nicht nachhaltig geklärt. Bekannt ist, dass Typ-2-Diabetiker erhöhte Konzentrationen freier Fettsäuren im Blut aufweisen. Der veränderte Fettstoffwechsel könnte neben bakteriellen Ursachen ein möglicher Grund für abakterielle Entzündungsreaktionen der Harnblase sein. Zur Prüfung dieser Hypothese wurden zeit- und konzentrationsabhängig kultivierte humane Detrusormyozyten im Vergleich zur Lipopolysaccharid (LPS) induzierten Entzündungsreaktion mit Palmitat stimuliert.

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Baran, Paul [Verfasser], Jürgen [Gutachter] Scheller, and Ulrich [Gutachter] Flögel. "Quantifizierung von Interleukin-6/löslichen Interleukin-6 Rezeptorkomplexen und Etablierung eines Nanopartikel-Zelltracking Systems über synthetische Cargo-Internalisierungsrezeptoren / Paul Baran ; Gutachter: Jürgen Scheller, Ulrich Flögel." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1163449873/34.

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Engelowski, Erika [Verfasser]. "Design synthetischer Zytokinrezeptoren für Interleukin-6- und Interleukin-23-artige Zytokine und Analyse der Rolle von Interleukin-23 in kardialer Ischämie / Erika Engelowski." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1188017705/34.

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