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Artykuły w czasopismach na temat „Intra-Abdominal candidiasis”

Autor: Grafiati

Data publikacji: 26 października 2024

Data aktualizacji: 31 lipca 2025

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1

Montravers, Philippe, Herve Dupont, and Philippe Eggimann. "Intra-abdominal candidiasis: the guidelines—forgotten non-candidemic invasive candidiasis." Intensive Care Medicine 39, no. 12 (2013): 2226–30. http://dx.doi.org/10.1007/s00134-013-3134-2.

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Rex, John H., and Jack D. Sobel. "Preventing intra-abdominal candidiasis in surgical patients." Critical Care Medicine 27, no. 6 (1999): 1033–34. http://dx.doi.org/10.1097/00003246-199906000-00001.

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Derek Oh, Kenneth Rodrigues, Blerina Asllanaj, Alexander Urzua, Andy He, and Rosaly Diaz. "Intra-abdominal abscess with Candida in a post-operative setting." World Journal of Advanced Research and Reviews 18, no. 1 (2023): 783–86. http://dx.doi.org/10.30574/wjarr.2023.18.1.0211.

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The goal in this case report is to discuss one presentation of the microbiology of the Candida species in an intra-abdominal abscess which is under reported. In general, the Candida species fungi is a common yeast found human beings as part of the microbiology. Common sites of candidiasis are often the oral cavity or the genitalia. Candida species have been found to have a mutualistic relationship with different species with the body [5]. When overproduction of Candida species occurs, it can cause pathological infections in patients. While it is common to see patients with Candida species in t

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4

Wan, Kaijing, Chong Kiat Khoo, and Rajeswari Kathirvel. "Unusual case of intra-abdominal candidiasis following laparoscopic hysterectomy." BMJ Case Reports 12, no. 4 (2019): e227897. http://dx.doi.org/10.1136/bcr-2018-227897.

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A 41-year-old woman with menorrhagia secondary to adenomyosis underwent an elective uncomplicated total laparoscopic hysterectomy after failed medical therapy. She developed fever, epigastric pain, nausea and diarrhoea on postoperative day (POD) 2. CT of abdomen and pelvis performed on POD 3 revealed an 8×3×3 cm fluid collection superior to the bladder. She did not respond to conservative treatment with intravenous antibiotics and therefore underwent an ultrasound-guided drainage on POD 7. The green-debris-laden fluid that was drained grewCandida. Investigations to screen for an immunocompromi

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5

Derek, Oh, Rodrigues Kenneth, Asllanaj Blerina, Urzua Alexander, He Andy, and Diaz Rosaly. "Intra-abdominal abscess with Candida in a post-operative setting." World Journal of Advanced Research and Reviews 18, no. 1 (2023): 783–86. https://doi.org/10.5281/zenodo.8175046.

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The goal in this case report is to discuss one presentation of the microbiology of the <em>Candida</em> species in an intra-abdominal abscess which is under reported.  In general, the <em>Candida</em> species fungi is a common yeast found human beings as part of the microbiology.  Common sites of candidiasis are often the oral cavity or the genitalia. <em>Candida</em> species have been found to have a mutualistic relationship with different species with the body [5]. When overproduction of <em>Candida</em> species occurs, it can cause pathologi

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6

Eggimann, Philippe, Patrick Francioli, Jacques Bille, et al. "Fluconazole prophylaxis prevents intra-abdominal candidiasis in high-risk surgical patients." Critical Care Medicine 27, no. 6 (1999): 1066–72. http://dx.doi.org/10.1097/00003246-199906000-00019.

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Hargarten, Jessica C., Audrey L. Atkin, and Deborah M. Brown. "The Candida albicans quorum-sensing molecule, farnesol, remodels the peritoneal cavity microenvironment to promote innate inflammatory responses in mice." Journal of Immunology 196, no. 1_Supplement (2016): 205.8. http://dx.doi.org/10.4049/jimmunol.196.supp.205.8.

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Abstract Candida albicans is a polymorphic fungus that causes mucosal candidiasis and life threatening, systemic and intra-abdominal disease in immunocompromised and transplant patients. In normal healthy adults, C albicans is maintained as a commensal mainly through the actions of innate cells. Secretion of the quorum-sensing molecule, farnesol, acts as a virulence factor for C. albicans during systemic infection, but is protective in oral models of infection. Despite the clinical importance of intra-abdominal candidiasis with a mortality rate as high as 65%, the role of farnesol in its patho

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8

Vergidis, Pascalis, Cornelius J. Clancy, Ryan K. Shields, et al. "Intra-Abdominal Candidiasis: The Importance of Early Source Control and Antifungal Treatment." PLOS ONE 11, no. 4 (2016): e0153247. http://dx.doi.org/10.1371/journal.pone.0153247.

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9

Montravers, Philippe, Olivier Leroy, and Christian Eckmann. "Intra-abdominal candidiasis: it’s still a long way to get unquestionable data." Intensive Care Medicine 41, no. 9 (2015): 1682–84. http://dx.doi.org/10.1007/s00134-015-3894-y.

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10

Behrns, K. E. "Caspofungin for prevention of intra-abdominal candidiasis in high-risk surgical patients." Yearbook of Surgery 2010 (January 2010): 237–38. http://dx.doi.org/10.1016/s0090-3671(09)79604-1.

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11

Senn, Laurence, Philippe Eggimann, Riadh Ksontini, et al. "Caspofungin for prevention of intra-abdominal candidiasis in high-risk surgical patients." Intensive Care Medicine 35, no. 5 (2009): 903–8. http://dx.doi.org/10.1007/s00134-009-1405-8.

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12

Pais, Marco Marotta, Rafael Zaragoza, Ignacio Martín-Loeches, Frederic F. Gómez-Bertomeu, and Alejandro Rodríguez. "Management of Intra-Abdominal Candidiasis in Intensive Care Setting: A Narrative Review." Journal of Fungi 11, no. 5 (2025): 362. https://doi.org/10.3390/jof11050362.

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Intra-abdominal candidiasis (IAC), with or without candidemia, is a common condition in patients in intensive care units (ICUs). Early diagnosis of IAC remains a challenge for clinicians despite new biomarkers. Early and appropriate antifungal treatment, which is associated with better clinical outcomes, is negatively affected by the increased isolation of non-albicans Candida strains that are resistant to the commonly used azoles and echinocandins. Based on the pharmacokinetic (PK) and pharmacodynamic (PD) properties of the different treatment options, liposomal amphotericin B, rezafungin or

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13

Novy, Emmanuel, François-Xavier Laithier, Jeremie Riviere та ін. "Protocol for the pBDG2 Study: Prospective Evaluation of 1.3-β-D-Glucan in the Peritoneal Fluid for the Diagnosis of Intra-Abdominal Candidiasis in Critically Ill Patients". Microbiology Research 12, № 1 (2021): 196–203. http://dx.doi.org/10.3390/microbiolres12010015.

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Background: The delayed diagnosis of the presence of Candida in severe intra-abdominal infections exposes patients to an increased risk of mortality. The prevalence of intra-abdominal candidiasis (IAC) varies with the type of intra-abdominal infection, the underlying conditions and the presence of risk factors for Candida infection. This study aims to evaluate the interest of the measure of 1.3-β-D-glucan (BDG) in the peritoneal fluid for the early diagnosis of IAC. Methods and analysis: This is a prospective multicenter (n = 5) non-interventional study, focusing on all critically ill patients

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14

Mesquida, Aina, Marina Machado, Lorena Dávila-Cherres, et al. "The Gastrointestinal Tract Is Pinpointed as a Reservoir of Candida albicans, Candida parapsilosis, and Candida tropicalis Genotypes Found in Blood and Intra-Abdominal Samples." Journal of Fungi 9, no. 7 (2023): 732. http://dx.doi.org/10.3390/jof9070732.

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Background: Candida spp., as part of the microbiota, can colonise the gastrointestinal tract. We hypothesised that genotyping Candida spp. isolates from the gastrointestinal tract could help spot genotypes able to cause invasive infections. Materials/methods: A total of 816 isolates of C. albicans (n = 595), C. parapsilosis (n = 118), and C. tropicalis (n = 103) from rectal swabs (n = 754 patients) were studied. Genotyping was conducted using species-specific microsatellite markers. Rectal swab genotypes were compared with previously studied blood (n = 814) and intra-abdominal (n = 202) genoty

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15

Cheng, Shaoji, Cornelius J. Clancy, Douglas J. Hartman, Binghua Hao, and M. Hong Nguyen. "Candida glabrata Intra-Abdominal Candidiasis Is Characterized by Persistence within the Peritoneal Cavity and Abscesses." Infection and Immunity 82, no. 7 (2014): 3015–22. http://dx.doi.org/10.1128/iai.00062-14.

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ABSTRACTThe pathogenesis ofCandida glabratainfections is poorly understood. We studied the pathogenesis of intra-abdominal candidiasis (IAC) in mice that were infected intraperitoneally withC. glabrataand sterile feces.C. glabrataBG2 (5 × 108CFU) caused a 100% mortality rate. Sublethal inocula of BG2 (1 × 108or 1 × 107CFU) caused peritonitis that progressed to abscesses. Three clinicalC. glabratastrains (5 × 108CFU) caused 80 to 100% mortality rates, while a fourth (strain 346) caused a 29% mortality rate. Following sublethal inocula (1 × 107CFU), the intra-abscess burdens of virulent strain 3

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16

Šašala, Martin, Emeše Majorová, Andrej Vrzgula, and Iveta Fandáková. "Evaluation of Invasive Intra-abdominal Candidiasis in Crohn Disease at the Time of Surgery." Annals of Coloproctology 36, no. 1 (2020): 12–16. http://dx.doi.org/10.3393/ac.2018.10.15.2.

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Purpose: The aim of this study was to determine whether a connection exists between Crohn disease and fungi, specifically Candida albicans, because one possible cause of disease is thought to be the presence of fungi in the intra-abdominal cavity. The diagnosis of invasive candidiasis is difficult due to the lack of specific clinical manifestations of the disease. A retrospective evaluation of the presence of invasive candidiasis was done in a group of 54 patients with Crohn disease and in a group of 31 patients who received surgery primarily for right-sided cancer of the colon.Methods: Cultur

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17

Colombo, Jacopo, Angela Arena, Daniela Codazzi, and Martin Langer. "Intra-abdominal candidiasis and probiotics: we know little but it’s time to try." Intensive Care Medicine 40, no. 2 (2013): 297–98. http://dx.doi.org/10.1007/s00134-013-3172-9.

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18

Janka, Vaskova. "Invasive yeast infection in patient with Acute pancreatitis." Imaging Journal of Clinical and Medical Sciences 4, no. 1 (2017): 006–10. https://doi.org/10.17352/2455-8702.000034.

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The incidence of invasive yeast infections is rising in patients hospitalised in intensive care. Their early diagnosis is problematic, although predictive models (Pitt’s colonization index, Leon score and others) can be helpful when deciding to initiate treatment. The incidence of candidiasis signifi cantly increases the mortality of patients, although the timely commencement of antimycotic therapy is a key factor in increasing their survival. In the present patient, antibiotic treatment with carbapenem was initiated after CT verifi cation of necrosis with formation of abscesses and the

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19

Díaz-García, Judith, Ana Gómez, Marina Machado, et al. "Candida Genotyping of Blood Culture Isolates from Patients Admitted to 16 Hospitals in Madrid: Genotype Spreading during the COVID-19 Pandemic Driven by Fluconazole-Resistant C. parapsilosis." Journal of Fungi 8, no. 11 (2022): 1228. http://dx.doi.org/10.3390/jof8111228.

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Background: Candidaemia and invasive candidiasis are typically hospital-acquired. Genotyping isolates from patients admitted to different hospitals may be helpful in tracking clones spreading across hospitals, especially those showing antifungal resistance. Methods: We characterized Candida clusters by studying Candida isolates (C. albicans, n = 1041; C. parapsilosis, n = 354, and C. tropicalis, n = 125) from blood cultures (53.8%) and intra-abdominal samples (46.2%) collected as part of the CANDIMAD (Candida in Madrid) study in Madrid (2019–2021). Species-specific microsatellite markers were

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20

Bassetti, Matteo, Antonio Vena, Daniele R. Giacobbe, et al. "Risk Factors for Intra-Abdominal Candidiasis in Intensive Care Units: Results from EUCANDICU Study." Infectious Diseases and Therapy 11, no. 2 (2022): 827–40. http://dx.doi.org/10.1007/s40121-021-00585-6.

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Krifors, Anders, Måns Ullberg, Markus Castegren, et al. "Combining T2Bacteria and T2Candida Panels for Diagnosing Intra-Abdominal Infections: A Prospective Multicenter Study." Journal of Fungi 8, no. 8 (2022): 832. http://dx.doi.org/10.3390/jof8080832.

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The T2Bacteria panel is a direct-from-blood assay that delivers rapid results, targeting E. coli, S. aureus, K. pneumoniae, A. baumanii, P. aeruginosa, and E. faecium (ESKAPE pathogens). In this study, T2Bacteria and T2Candida (targeting C. albicans/C. tropicalis, C. glabrata/C. krusei, and C. parapsilosis) were evaluated in parallel with blood cultures in 101 consecutive surgical patients with suspected intra-abdominal infection admitted to the intensive care unit or high dependency unit. Fifteen patients had bacteremia, with T2Bacteria correctly identifying all on-panel (n = 8) pathogens. T2

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22

de la Torre, Pola, and Annette C. Reboli. "Anidulafungin: Review of its Role in the Treatment of Invasive Candidiasis." Clinical Medicine Insights: Therapeutics 3 (January 2011): CMT.S3153. http://dx.doi.org/10.4137/cmt.s3153.

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In 2006 a third echinocandin, anidulafungin, was approved in the USA for the treatment of candida esophagitis, candidemia, and invasive candida infections such as intra-abdominal abscesses and peritonitis in the non-neutropenic patient. Two years later it was approved in the EU for invasive candidiasis in non-neutropenic patients. Like other echinocandins, it is fungicidal against Candida species and fungistatic against Aspergillus species. It does not need adjustment for renal or hepatic insufficiency, and has no known drug interactions. Its administration is by the intravenous route only, an

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23

De Oliveira, Michael Éder, William Gustavo De Lima, Carla Ferreira Bruno Alves, et al. "Synergetic action of atorvastatin and fluconazole against fluconazole-resistant Candida albicans in vitro and in a murine model for intra-abdominal Candidiasis / Ação sinérgica da atorvastatina e fluconazol contra Candida albicans resistente ao fluconazol in vitro e em um modelo murino contra Candidíase intra-abdominal." Brazilian Journal of Development 8, no. 5 (2022): 41115–37. http://dx.doi.org/10.34117/bjdv8n5-543.

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Introduction: Candida albicans is the most common causative agent of Intra-abdominal Candidiasis (IAC) and it is resistant to most antifungal drugs currently available. Here we investigated atorvastatin in vitro and in vivo antifungal activities against a fluconazole-resistant C. albicans strain as a potential repurposed drug. The following tests were carried out: antifungal susceptibility tests to determine minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), determination of time-kill curve, biofilm assays, Candida albicans yeast-hyphae transition inhibition ass

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Meena, Durga Shankar, and Deepak Kumar. "<b><i>Candida</i></b> Pneumonia: An Innocent Bystander or a Silent Killer?" Medical Principles and Practice 31, no. 1 (2021): 98–102. http://dx.doi.org/10.1159/000520111.

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Invasive candidiasis is predominantly seen in immunosuppressed patients and carries a significant mortality. The clinical spectrum of invasive candidiasis encompasses candidemia and disseminated infection (intra-abdominal abscess, osteomyelitis, endophthalmitis, and <i>Candida</i> meningitis). The existence of <i>Candida</i> pneumonia has been largely debated over the years due to its rarity and presence of frequent colonization. Demonstration of <i>Candida</i> species by lung biopsy along with evidence of inflammation is the only way to confirm this entity.

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Cheng, Shaoji, Cornelius J. Clancy, Wenjie Xu, et al. "Profiling of Candida albicans Gene Expression During Intra-abdominal Candidiasis Identifies Biologic Processes Involved in Pathogenesis." Journal of Infectious Diseases 208, no. 9 (2013): 1529–37. http://dx.doi.org/10.1093/infdis/jit335.

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Pea, F., E. Righi, P. Cojutti, et al. "Intra-abdominal penetration and pharmacodynamic exposure to fluconazole in three liver transplant patients with deep-seated candidiasis." Journal of Antimicrobial Chemotherapy 69, no. 9 (2014): 2585–86. http://dx.doi.org/10.1093/jac/dku169.

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Bassetti, Matteo, Monia Marchetti, Arunaloke Chakrabarti, et al. "A research agenda on the management of intra-abdominal candidiasis: results from a consensus of multinational experts." Intensive Care Medicine 39, no. 12 (2013): 2092–106. http://dx.doi.org/10.1007/s00134-013-3109-3.

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KAYANO, Masashi, Kenya YAMANAKA, Yumiko FUJIWARA, Misaki TASHIMA, Kaichiro HARADA, and Jun TAMURA. "A Case of Surgical Drainage for Intra-abdominal Candidiasis after Peritonitis due to a Perforated Duodenal Ulcer." Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 83, no. 8 (2022): 1544–49. http://dx.doi.org/10.3919/jjsa.83.1544.

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Huseynov, Ravil M., Samir S. Javadov, Ali Osmanov, et al. "The burden of serious fungal infections in Azerbaijan." Therapeutic Advances in Infectious Disease 8 (January 2021): 204993612110439. http://dx.doi.org/10.1177/20499361211043969.

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Background: Azerbaijan is an upper middle-income country in South Caucasus with an area of 86,600 km2 and a total population of 10 million people and gross domestic product of US $4480 per capita. The aim of this research is to estimate fungal infection burden and highlight the problem at national and international levels. Methods: Fungal infection burden was estimated using data from epidemiological papers and population at risk and LIFE (Leading International Fungal Education) modelling. Results: The number of people living with human immunodeficiency virus (PLHIV) in 2018 was 6193, 29% of t

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Bassetti, Matteo, Maddalena Peghin, Alessia Carnelutti, et al. "Clinical characteristics and predictors of mortality in cirrhotic patients with candidemia and intra-abdominal candidiasis: a multicenter study." Intensive Care Medicine 43, no. 4 (2017): 509–18. http://dx.doi.org/10.1007/s00134-017-4717-0.

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Dupont, Hervé, Stéphanie Malaquin, Léonie Villeret, et al. "Is ß-d-glucan Relevant for the Diagnosis and Follow-up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection?" Journal of Fungi 8, no. 5 (2022): 487. http://dx.doi.org/10.3390/jof8050487.

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The usefulness of (1,3)-ß-d-glucan (BDG) detection for the diagnosis of intra-abdominal candidiasis and treatment monitoring is unknown. A prospective, single-center study of consecutive patients admitted to an ICU with complicated intra-abdominal infection (IAI) over a 2-year period was conducted. BDG was measured in the peritoneal fluid and serum between day 1 (D1) and D10. Patients with a positive peritoneal fluid yeast culture (YP) were compared to those with a negative yeast culture (YN). The evolution of serum BDG was compared in the two groups. Seventy patients were included (sixty-five

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Fidel, Paul L., Junko Yano, Shannon K. Esher, and Mairi C. Noverr. "Applying the Host-Microbe Damage Response Framework to Candida Pathogenesis: Current and Prospective Strategies to Reduce Damage." Journal of Fungi 6, no. 1 (2020): 35. http://dx.doi.org/10.3390/jof6010035.

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Disease is a complex outcome that can occur as a result of pathogen-mediated damage, host-mediated damage or both. This has led to the revolutionary concept of the damage response framework (DRF) that defines microbial virulence as a function of host immunity. The DRF outlines six scenarios (classes) of host damage or beneficial outcomes, depending on the microbe and the strength of the immune response. Candida albicans is uniquely adapted to its human host and can exist as either a commensal, colonizing various anatomical sites without causing notable damage, or as a pathogen, with the abilit

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Maseda, Emilio, Alejandro H. Rodríguez, Gerardo Aguilar, et al. "EPICO 3.0. Recommendations on invasive candidiasis in patients with complicated intra-abdominal infection and surgical patients with ICU extended stay." Revista Iberoamericana de Micología 33, no. 4 (2016): 196–205. http://dx.doi.org/10.1016/j.riam.2016.02.003.

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Yan, Ting, Shuang-Ling Li, Hai-Li Ou, Sai-Nan Zhu, Lei Huang, and Dong-Xin Wang. "Appropriate Source Control and Antifungal Therapy are Associated with Improved Survival in Critically Ill Surgical Patients with Intra-abdominal Candidiasis." World Journal of Surgery 44, no. 5 (2020): 1459–69. http://dx.doi.org/10.1007/s00268-020-05380-x.

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Clancy, Cornelius J., Palash Samanta, Shaoji Cheng, Kevin Squires, and Minh-Hong Nguyen. "1726. Candida albicans Virulence Genes Induced During Intra-abdominal Candidiasis (IAC) in the Absence of Antifungal Exposure Mediate Echinocandin Resistance." Open Forum Infectious Diseases 6, Supplement_2 (2019): S633. http://dx.doi.org/10.1093/ofid/ofz360.1589.

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Abstract Background We developed and validated a mouse model of C. albicans IAC that mimics peritonitis and abscesses (IAA) in humans, and that is amenable to temporal–spatial transcriptional profiling and virulence studies. Methods We measured C. albicans SC5314 gene expression by RNA-Seq (RiboPure extraction; Illumina MiSeq) in triplicate during early peritonitis (within 30 minutes of infection), late peritonitis (24 hours) and IAA (48 hours). Differential expression was defined by ≥2-fold differences at false discovery rate ≤0.01. Results ≥7 million C. albicans reads were detected in each e

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Clancy, Cornelius J., Shaoji Cheng, Kevin Squires, and Minh-Hong Nguyen. "2887. Identifying Candida albicans Transcription Factors (TFs) That Regulate Pathogenesis of Intra-abdominal Candidiasis (IAC) by Screening a Deletion Mutant Library." Open Forum Infectious Diseases 6, Supplement_2 (2019): S77. http://dx.doi.org/10.1093/ofid/ofz359.165.

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Abstract Background IAC is a common manifestation of invasive candidiasis, but its pathogenesis is poorly understood. We developed a mouse model of C. albicans IAC, in which disease progresses from peritonitis to abscesses (IAA) in a manner that recapitulates human infection. Our goal was to use the model to identify C. albicans TFs that regulate virulence during IAC. Methods We screened a signature-tagged library (48 unique oligonucleotide markers) of homozygous deletion mutants for 165 C. albicans TF genes, created in duplicate in strain SC5314 (S. Noble). Mice were infected intra-peritoneal

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Sganga, Gabriele, Minggui Wang, M. Rita Capparella, et al. "Evaluation of anidulafungin in the treatment of intra-abdominal candidiasis: a pooled analysis of patient-level data from 5 prospective studies." European Journal of Clinical Microbiology & Infectious Diseases 38, no. 10 (2019): 1849–56. http://dx.doi.org/10.1007/s10096-019-03617-9.

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Novy, Emmanuel, Mathieu Esposito, Anne Debourgogne та Claire Roger. "Reevaluating the Value of (1,3)-β-D-Glucan for the Diagnosis of Intra-Abdominal Candidiasis in Critically Ill Patients: Current Evidence and Future Directions". Journal of Fungi 11, № 2 (2025): 91. https://doi.org/10.3390/jof11020091.

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Intra-abdominal candidiasis (IAC) is associated with significant diagnostic and therapeutic challenges in critically ill patients. Traditional fungal cultures are slow, delaying appropriate antifungal treatment. (1,3)-β-D-glucan (BDG), a component of the fungal cell wall, has emerged as a potential biomarker for IAC, but its use in ICU settings is complicated by frequent false-positives results from invasive procedures and underlying conditions. This review examines the diagnostic value of BDG when present in serum and peritoneal fluid. While serum BDG is effective for excluding invasive funga

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Fortún, J., M. J. Buitrago, F. Gioia та ін. "Roles of the multiplex real-time PCR assay and β-D-glucan in a high-risk population for intra-abdominal candidiasis (IAC)". Medical Mycology 58, № 6 (2019): 789–96. http://dx.doi.org/10.1093/mmy/myz123.

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Abstract Multiplex quantitative real-time PCR (MRT-PCR) using blood can improve the diagnosis of intra-abdominal candidiasis (IAC). We prospectively studied 39 patients with suspected IAC in the absence of previous antifungal therapy. Blood cultures, MRT-PCR, and β-D-glucan (BDG) in serum were performed in all patients. IAC was defined according to the 2013 European Consensus criteria. For MRT-PCR, the probes targeted the ITS1 or ITS2 regions of ribosomal DNA. Candidaemia was confirmed only in four patients (10%), and IAC criteria were present in 17 patients (43.6%). The sensitivity of MRT-PCR

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Lagunes, L., A. Rey-Pérez, M. T. Martín-Gómez, et al. "Association between source control and mortality in 258 patients with intra-abdominal candidiasis: a retrospective multi-centric analysis comparing intensive care versus surgical wards in Spain." European Journal of Clinical Microbiology & Infectious Diseases 36, no. 1 (2016): 95–104. http://dx.doi.org/10.1007/s10096-016-2775-9.

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Breitkopf, Robert, Benedikt Treml, Thomas Senoner, Zoran Bukumirić, and Sasa Rajsic. "Invasive Fungal Breakthrough Infections under Targeted Echinocandin Prophylaxis in High-Risk Liver Transplant Recipients." Journal of Fungi 9, no. 2 (2023): 272. http://dx.doi.org/10.3390/jof9020272.

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Invasive fungal infections (IFIs) are frequent and outcome-relevant complications in the early postoperative period after orthotopic liver transplantation (OLT). Recent guidelines recommend targeted antimycotic prophylaxis (TAP) for high-risk liver transplant recipients (HR-LTRs). However, the choice of antimycotic agent is still a subject of discussion. Echinocandins are increasingly being used due to their advantageous safety profile and the increasing number of non-albicans Candida infections. However, the evidence justifying their use remains rather sparse. Recently published data on break

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Shields, Ryan K., M. Hong Nguyen, Ellen G. Press, et al. "The Presence of anFKSMutation Rather than MIC Is an Independent Risk Factor for Failure of Echinocandin Therapy among Patients with Invasive Candidiasis Due to Candida glabrata." Antimicrobial Agents and Chemotherapy 56, no. 9 (2012): 4862–69. http://dx.doi.org/10.1128/aac.00027-12.

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ABSTRACTEchinocandins are frontline agents against invasive candidiasis (IC), but predictors for echinocandin therapeutic failure have not been well defined. Mutations inCandida FKSgenes, which encode the enzyme targeted by echinocandins, result in elevated MICs and have been linked to therapeutic failures. In this study, echinocandin MICs by broth microdilution andFKS1andFKS2mutations amongC. glabrataisolates recovered from patients with IC at our center were correlated retrospectively with echinocandin therapeutic responses. Thirty-five patients with candidemia and 4 with intra-abdominal abs

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Maseda, Emilio, Alejandro H. Rodríguez, Gerardo Aguilar, et al. "Erratum to: “EPICO 3.0. Recommendations on invasive candidiasis in patients with complicated intra-abdominal infection and surgical patients with ICU extended stay” [Rev Iberoam Micol. 33 (4) (2016) 196–205]." Revista Iberoamericana de Micología 34, no. 1 (2017): 61. http://dx.doi.org/10.1016/j.riam.2017.02.002.

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Dunaiski and Denning. "Estimated Burden of Fungal Infections in Namibia." Journal of Fungi 5, no. 3 (2019): 75. http://dx.doi.org/10.3390/jof5030075.

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Namibia is a sub-Saharan country with one of the highest HIV infection rates in the world. Although care and support services are available that cater for opportunistic infections related to HIV, the main focus is narrow and predominantly aimed at tuberculosis. We aimed to estimate the burden of serious fungal infections in Namibia, currently unknown, based on the size of the population at risk and available epidemiological data. Data were obtained from the World Health Organization (WHO), Joint United Nations Programme on HIV/AIDS (UNAIDS), and published reports. When no data existed, risk po

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Cheng, Shaoji, Badrane Hassan, Guojun Liu, Cornelius J. Clancy, and Minh-Hong Nguyen. "116. Characterization of small colony variants from a patient with bloodstream infection of Candida glabrata." Open Forum Infectious Diseases 8, Supplement_1 (2021): S70—S71. http://dx.doi.org/10.1093/ofid/ofab466.116.

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Abstract Background Bacterial small colony variants (SCVs) that are tolerant to commonly used antibiotics are well recognized. Clinical SCV Candida have been rarely reported. We describe SCV C. glabrata (CG) strains recovered from within a population causing bloodstream infection (BSI) in a patient (pt), which were not recognized by the micro lab. Pt J developed CG BSI shortly after liver transplant (OLTX), which was treated with voriconazole (VOR). VOR was also used for post-OLTX mold prophylaxis. 67 d after BSI, he developed intra-abdominal infection due to VOR-resistant CG. We hypothesized

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Alexander, Barbara D., Oliver Cornely, Peter Pappas, et al. "1248. Efficacy and Safety of Oral Ibrexafungerp in 41 Patients with Refractory Fungal Diseases, Interim Analysis of a Phase 3 Open-label Study (FURI)." Open Forum Infectious Diseases 7, Supplement_1 (2020): S642. http://dx.doi.org/10.1093/ofid/ofaa439.1432.

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Abstract Background Candida infections resistant to currently available antifungals are an emerging global threat. Ibrexafungerp is an investigational broad-spectrum glucan synthase inhibitor antifungal with activity against Candida and Aspergillus species, including azole- and echinocandin-resistant strains. A Phase 3 open-label, single-arm study of oral ibrexafungerp (FURI) (Clinicaltrials.gov NCT03059992) is ongoing for the treatment of patients (≥18 years) with fungal diseases who are intolerant of or refractory to standard antifungal therapies. Methods An independent Data Review Committee

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Azim, Afzal, Armin Ahmed, Arvind Kumar Baronia, Rungmei S. K. Marak, and Nabeel Muzzafar. "Intra-Abdominal Candidiasis." EMJ Nephrology, July 18, 2017, 82–93. http://dx.doi.org/10.33590/emjnephrol/10310735.

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Intra-abdominal candidiasis (IAC) is the second most common form of invasive candidiasis after candidaemia. IAC is a broad term and can be classified on the basis of anatomical site (Candida peritonitis, pancreatic candidiasis, biliary tract candidiasis, gastrointestinal candidiasis, and hepatosplenic candidiasis) as well as clinical setting (community acquired versus nosocomial). The risk factors linked with IAC are candida colonisation, anastomotic leak, multiple instrumentation, long-term broad spectrum antibiotic use, total parenteral nutrition, and immunocompromised state. Clinically, IAC

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Liao, Min, Xuekui Xia, Qingzhou Meng, et al. "Holotoxin A₁ from Apostichopus japonicus inhibited oropharyngeal and intra‐abdominal candidiasis by inducing oxidative damage in Candida albicans." British Journal of Pharmacology, February 21, 2024. http://dx.doi.org/10.1111/bph.16333.

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AbstractBackground and PurposeThe holotoxin A1, isolated from Apostichopus japonicus, exhibits potent antifungal activities, but the mechanism and efficacy against candidiasis are unclear. In this study we have studied the antifungal effects and mechanism of holotoxin A1 against Candida albicans and in murine oropharyngeal and intra‐abdominal candidiasis.Experimental ApproachThe antifungal effect of holotoxin A1 against C. albicans was tested in vitro. To explore the antifungal mechanism of holotoxin A1, the transcriptome, ROS levels, and mitochondrial function of C. albicans was evaluated. Ef

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Habighorst, Kelsey, James M. Sanders, Sara A. Hennessy, Kristina Goff, Bingchun Wan, and Meagan Johns. "Identification of Risk Factors for Intra-Abdominal Candidiasis." Surgical Infections, November 23, 2023. http://dx.doi.org/10.1089/sur.2023.149.

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Lee, Annie, Ning Wang, Claire L. Carter, et al. "Therapeutic Potential of Fosmanogepix (APX001) for Intra-abdominal Candidiasis: from Lesion Penetration to Efficacy in a Mouse Model." Antimicrobial Agents and Chemotherapy 65, no. 4 (2021). http://dx.doi.org/10.1128/aac.02476-20.

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Intra-abdominal candidiasis (IAC) is one of the most common yet underappreciated forms of invasive candidiasis. IAC is difficult to treat, and therapeutic failure and drug-resistant breakthrough infections are common in some institutions despite the use of echinocandins as first-line agents.

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