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Rozprawy doktorskie na temat „Intracellular uptake”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Nativo, Paola. "Uptake and Intracellular Fate of Surface-Modified Gold Nanoparticles." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507707.

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Hassuna, Noha. "The role of tetraspanins in the uptake of intracellular pathogens." Thesis, University of Sheffield, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522414.

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LETTIERO, BARBARA. "Uptake and intracellular trafficking of nanoparticles for potential medical use." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/20247.

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My PhD project has been focused on the characterization of the in vitro behavior of engineered Nanoparticles (NPs), especially concerning the first phases of interaction with barriers of different nature present in the body : a model of air-blood barrier , e.g. alveolar epithelial A30 cell line and an immunological barrier represented by the activation of the complement system. In light of these considerations, I have first compared the mechanism of cellular uptake and intracellular distribution of Solid Lipid NPs and Iron Oxide NPs over time. Then, I have studied the likely molecular basis of

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Tünnemann, Gisela. "Toxicity, uptake and applications of intracellular delivery by cell penetrating peptides." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-105432.

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Schütz, Irene [Verfasser]. "Uptake and intracellular delivery of nanoparticles into mammalian cells / Irene Schütz." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1104170698/34.

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6

Wei, Hai. "Analysis and intracellular uptake of ß-cyclodextrin and a ß-cyclodextrin complex." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0010/MQ60194.pdf.

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7

Chindera, Kantaraja. "Cell uptake properties of Polyhexamethylene Biguanide (PHMB) and applications in intracellular delivery." Thesis, Royal Veterinary College (University of London), 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618319.

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Jindi, Elias Sonav. "Evaluation of mechanisms for accessing intracellular targets for protein-based drugs." Thesis, Uppsala universitet, Avdelningen för farmaceutisk biokemi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445320.

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Over the years, biological drugs have evolved and have made breakthroughs in diseases associated with extracellular proteins. However, intracellular proteins that cause disease progression are still largely inaccessible. Examples of diseases that are caused by an intracellular aggregation of proteins are neurodegenerative diseases such as Parkinson's disease, Huntington's disease (HD), and Alzheimer's disease (AD). The purpose of the work is to find a strategy to reach the neurons intracellularly. The goal is to be able to design a biological drug that enters the neuron by investigating differ

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9

Pelc, Radek. "Calcium mobilisation and uptake in smooth muscle cells : role of intracellular calcium stores." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275402.

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Clark, S. A. "The mechanism of uptake and intracellular fate of leupeptin in rat yolk sacs." Thesis, Keele University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376309.

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11

Al-Kotaji, Myasar. "The multifunctional peptide, Tat-LK15 : a study of its cellular uptake and its potential use in drug delivery." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/the-multifunctional-peptide-tatlk15a-study-of-its-cellular-uptake-and-its-potential-use-in-drug-delivery(92514766-2626-4949-8e02-ca77dc88ff7b).html.

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Cell penetrating peptides (CPPs) have been used in many areas of drug delivery for mediating the delivery of peptides, protein, DNA, siRNA and liposomes. Additionally they have shown an ability to overcome drug resistance in cells enhancing chemotherapeutic activity. Our group has recently designed a promising multifunctional peptide, Tat-LK15, originating from the fusion of Tat peptide (49-57) with the synthetic amphipathic peptide, LK15. TAT-LK15 was found to be efficient at mediating DNA and siRNA delivery to cells especially contributing to the silencing of bcr-abl oncoprotein over a long

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12

Albarran, Brian. "TAT-streptavidin : a novel drug delivery vector for the intracellular uptake of macromolecular cargo /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8016.

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Lerch, Simone [Verfasser]. "Uptake mechanism, intracellular trafficking and endo-lysosomal pH monitoring of polystyrene nanoparticles / Simone Lerch." Mainz : Universitätsbibliothek Mainz, 2012. http://d-nb.info/102016414X/34.

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Hawke, Thomas James. "Intracellular calcium's role in methylxanthine-induced changes in potassium uptake in mammalian skeletal muscle." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0026/NQ51039.pdf.

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15

Wang, Kening. "Changes in Intracellular Chloride During Osmotic Stress and L-alanine Uptake in Mouse Hepatocytes." Digital Commons @ East Tennessee State University, 1992. https://dc.etsu.edu/etd/2821.

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A stable intracellular ionic environment is necessary for hepatocytes to function normally. Thus, during hypotonic shock or L-alanine uptake, hepatocytes swell and then exhibit a regulatory volume decrease (RVD), which comprises an increase in K$\sp+$ conductance (G$\sb{\rm K}$), an increased K$\sp+$ efflux, and a hyperpolarization of transmembrane potential (V$\sb{\rm m}$). Since hepatocyte intracellular Cl$\sp-$ has been demonstrated to distribute passively with V$\sb{\rm m}$, this study is designed to test the hypothesis that the hypotonic shock- or L-alanine uptake-induced hyperpolarizatio

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16

Iwata, Masahiro, 全広岩田, Kimihide Hayakawa, et al. "Uniaxial Cyclic Stretch-Stimulated Glucose Transport Is Mediated by a Ca2+-Dependent Mechanism in Cultured Skeletal Muscle Cells." Thesis, Karger, 2007. http://hdl.handle.net/2237/11109.

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"Uniaxial Cyclic Stretch-Stimulated Glucose Transport Is Mediated by a Ca2+-Dependent Mechanism in Cultured Skeletal Muscle Cells" Pathobiology, v.74, n.3, pp.159-168を、博士論文として提出したもの。<br>名古屋大学博士学位論文学位の種類:博士（リハビリテーション療法学）（課程）学位授与年月日:平成19年3月23日

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17

Zimmermann, Kristen Ann. "Intracellular Transport in Cancer Treatments: Carbon Nanohorns Conjugated to Quantum Dots and Chemotherapeutic Agents." Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/72986.

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Cancer therapies are often limited by bulk and cellular barriers to transport. Nanoparticle or chemotherapeutic compound intracellular transport has implications in understanding therapeutic effect and toxicity. The scope of this thesis was to study the intracellular transport of carbon nanohorns and to improve the efficacy of various chemotherapeutic agents through increased intracellular transport. In the first study, fluorescent probes (quantum dots) were conjugated to carbon nanohorns to facilitate the optical visualization of the nanohorns. These hybrid particles were characterized wi

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18

Liu, Ying. "The impact of physical and biological factors on intracellular uptake, trafficking and gene transfection after ultrasound exposure." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/43626.

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We used megahertz pulsed ultrasound and studied gene transfection with a human prostate cancer cell line. We first studied the compromise of cell viability and uptake efficiency and found out that increasing sonication temperature or changing US contrast agents could improve drug/gene delivery mediated by US exposure. We also found that accounting for cell debris after sonication was important to correctly determine cell viability. Next, we verified the capability of US to deliver DNA into the cell nuclei, which is necessary for successful gene transfection. Under the optimal sonication condit

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19

Collis, Lisa Janine. "Rapid hyaluronan uptake is associated with enhanced motility and transformation, implications for an intracellular mode of action." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ45877.pdf.

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20

He, Jia. "Identification and Characterization of Metal Uptake Loci in Porphyromonas gingivalis." Available to VCU users at :, 2007. http://hdl.handle.net/10156/1263.

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21

Johnston, Helinor. "Evaluating the uptake, intracellular fate and functional consequences of hepatocyte exposure to a range of nanoparticles, in vitro." Thesis, Edinburgh Napier University, 2009. http://researchrepository.napier.ac.uk/Output/2548.

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The liver is recognised as a potential target site for nanoparticle (NP) toxicity, as NPs have been observed to accumulate within this organ subsequent to exposure via injection, inhalation or instillation. The liver's unique structure has to be taken into consideration when evaluating NP toxicity, as a variety of cell types of distinct morphology and function are evident, and potentially affected by NP exposure. Of particular interest are hepatocytes, due to their abundance and importance to the maintenance of normal liver function, and macrophages due to their role in host defence. The uptak

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22

Ali, Rizwan. "Live Cell Imaging of Intracellular Uptake of Contaminant Molecules (B[a]P) and its Effects on Different Cellular Compartments." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-91967.

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Exposure of hepatoma cell lines to the polycyclic aromatic hydrocarbon benzo[a]pyrene (B[a]P) is serving as a model for a systems biological study concerning the response of cells to contaminant molecules. Several aspects of the cellular distribution of the aryl hydrocarbon receptor (AhR) and its ligand B[a]P have been addressed by different live cell imaging techniques: The intracellular distribution of the B[a]P/AhR complex is visualized by means of confocal laser scaning microscopy (cLSM) and the intracellular transport rates of the complex is investigated by fluorescence recovery after pho

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23

Bandzaitytė, Leona. "Fluorescence research on the uptake and intracellular localisation of colloidal quantum dots and their effect on mechanisms of endocytosis." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20141209_112222-34946.

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The overall aim of the study is to identify the general rules for intracellular uptake and localisation of non-targeted nanoparticles by employing colloid quantum dots (QDs) as a model of biocompatible nanoparticle-based drug carriers. The investigation of intracellular uptake of non-targeted negatively charged QDs with fluorescence spectroscopy method revealed three time-related accumulation stages, which are characteristic for all investigated cell lines, but the stages were of different timing for each of the investigated cell line. The confocal fluorescence microscopy imaging showed four i

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24

Polito, Anthony B. III. "Manipulation of Gold Nanorod Physicochemical Properties to Enhance Biocompatibility, Uptake and Intracellular Preservation of Optical Properties for Bio-Imaging and Plasmonic Photo-Therapeutic Applications." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1440598544.

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25

Willmann, Wiebke [Verfasser], Ralf [Akademischer Betreuer] Dringen, Heinrich [Gutachter] Hofmann, and Ciacchi Lucio [Gutachter] Colombi. "Synthesis and characterization of fluorescent iron oxide nanoparticles to study uptake and intracellular trafficking of nanoparticles in neural cells / Wiebke Willmann ; Gutachter: Heinrich Hofmann, Lucio Colombi Ciacchi ; Betreuer: Ralf Dringen." Bremen : Staats- und Universitätsbibliothek Bremen, 2018. http://d-nb.info/1161096663/34.

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Ali, Rizwan [Verfasser], Gerhard Akademischer Betreuer] Rödel, Thomas [Akademischer Betreuer] Hanke, Gerhard [Gutachter] Rödel, and Michael [Gutachter] [Gelinsky. "Live Cell Imaging of Intracellular Uptake of Contaminant Molecules (B[a]P) and its Effects on Different Cellular Compartments / Rizwan Ali ; Gutachter: Gerhard Rödel, Michael Gelinsky ; Gerhard Rödel, Thomas Hanke." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://d-nb.info/1150309326/34.

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27

Theodoropoulos, Christina. "Pathogenicity of Plesiomonas shigelloides : interactions with eukaryotic host cells in vitro." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/37160/6/37160_Digitised%20Thesis.pdf.

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Diarrhoea is one of the leading causes of morbidity and mortality in populations in developing countries and is a significant health issue throughout the world. Despite the frequency and the severity of the diarrhoeal disease, mechanisms of pathogenesis for many of the causative agents have been poorly characterised. Although implicated in a number of intestinal and extra-intestinal infections in humans, Plesiomonas shigelloides generally has been dismissed as an enteropathogen due to the lack of clearly demonstrated virulence-associated properties such as production of cytotoxins and

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Reifarth, Martin [Verfasser], Ulrich Sigmar [Gutachter] Schubert, and Rainer [Gutachter] Heintzmann. "Uptake and intracellular fate of polymeric nanoparticles studied by light and electron microscopy : from labeling strategies for polymers towards a correlative microscopy approach / Martin Reifarth ; Gutachter: Ulrich Sigmar Schubert, Rainer Heintzmann." Jena : Friedrich-Schiller-Universität Jena, 2018. http://d-nb.info/1206605006/34.

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Hagen, Tracey Ann. "Mechanisms of Iron Acquisition Employed by Neisseria Gonorrhoeae for Survival within Cervical Epithelial Cells." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/2125.

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Le, Tinh. "Determination of Cisplatin using Hydrophilic Interaction Liquid Chromatography (HILIC) Coupled with Inductively Coupled Plasma Mass Spectrometry (ICP-MS): A Study on Cisplatin’s Retention Mechanisms in HILIC and Uptake and Intracellular Decay Kinetics in in-vitro Grown Cells." Thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-56554.

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Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is widely used for the treatment of several solid tumors. The antitumor property of cisplatin is generally proved that the covalent binding of cisplatin to DNA distorts the DNA structure, which leads to the death of the cancer cells. The obstacle for chemotherapy is that tumors can acquire resistance to cisplatin and induce the severe side effects associated with cisplatin treatment. How cisplatin enters the cells and metabolizes in cytoplasm is not completely elucidated. The purpose of this project was to study the kinetics of cellular uptake

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31

Dellinger, Marc. "Etude de l'interaction de porphyrines et de leurs derives avec des cellules leucemiques en culture." Paris 6, 1987. http://www.theses.fr/1987PA066332.

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32

Koumanov, Françoise. "Evaluation biologique d'analogues iodés du glucose : étude de leurs interactions avec le transporteur." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10115.

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De nombreux etats pathologiques, tels le diabete, les maladies cerebrales, l'ischemie myocardique et le cancer, sont associes a des troubles dans le transport ou le metabolisme intracellulaire du glucose. L'appreciation in vivo chez l'homme des variations pathologiques de la captation du glucose revet donc une grande importance en medecine. Pour ces raisons nous avons oriente notre travail vers la recherche de nouveaux analogues du glucose marques a l'iode 123, un radioelement emetteur et utilisables dans tous les services de medecine nucleaire. Pour proceder a l'evaluation biologique de ces a

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33

Cheng, Ting-Yun, and 鄭婷云. "Investigating the Oligonucleotide-assembled Nanocomplexes on Intracellular Uptake and Application of Cell Targeting." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/56331337554649706222.

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碩士<br>國立臺灣大學<br>高分子科學與工程學研究所<br>98<br>Generally, particle uptake by cells is mediated by electrostatic interactions of positively charged particles with negatively charged cellular surface, so the cationic polyplexes showed efficiently cellular transfection. However, YC Chung et al. developed a new complex with high transfection efficiency by assembling negatively charged single-stranded oligonucleotides with polycation/DNA complexes. Therefore, this project investigated the cellular uptake pathway of single-stranded oligonucleotides with polycation/DNA complexes. The results of different inhi

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Bannister, Aaron. "Modulation of nanoparticle uptake, intracellular distribution, and retention with docetaxel to enhance radiotherapy." Thesis, 2019. http://hdl.handle.net/1828/11355.

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OBJECTIVE: One of the major issues in current radiotherapy (RT) is the normal tissue toxicity. A smart combination of agents within the tumor would allow lowering the RT dose required while minimizing the damage to healthy tissue surrounding the tumor. We chose gold nanoparticles (GNPs) and docetaxel (DTX) as our choice of two radiosensitizing agents. They have a different mechanism of action which could lead to synergistic effect. Our first goal was to assess the variation in GNP uptake, distribution, and retention in the presence of DTX. Our second goal was to assess the therapeutic resu

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Tünnemann, Gisela [Verfasser]. "Toxicity, uptake and applications of intracellular delivery by cell penetrating peptides / vorgelegt von Gisela Tünnemann." 2009. http://d-nb.info/996663738/34.

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Tzu-Yu, Lai. "Influence of substitutions on meso-substituted porphyrins with regard to intracellular uptake , subcellular localization and photodynamic therapy (PDT) effect." 2006. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2407200608343900.

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Lai, Tzu-Yu, and 賴子瑜. "Influence of substitutions on meso-substituted porphyrins with regard to intracellular uptake , subcellular localization and photodynamic therapy (PDT) effect." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/12250835744320332255.

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碩士<br>國立臺灣大學<br>醫學工程學研究所<br>94<br>The search for new efficient photosensitizers in photodynamic therapy (PDT) points to improve photophysical properties like absorption in the red region and singlet oxygen quantum yield as well as to control the localization of the sensitizer within the tumor cell. Depending on their physicochemical properties and their uptake mechanism, photosensitizers can reach different intracellular concentrations and localize in different subcellular compartments . Moreover, the preferential localization of a photosensitizer in target organelles, such as mitochondria or

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Stegall, Lisa Ferguson. "The effects of carbohydrate-protein supplementation on endurance exercise performance, recovery, and training adaptation." Thesis, 2010. http://hdl.handle.net/2152/ETD-UT-2010-12-2168.

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Recent research suggests that adding protein (PRO) to a carbohydrate (CHO) supplement can have substantial benefits for endurance exercise performance and recovery beyond that of CHO alone. CHO+PRO supplements are often commercially available formulations consisting of carbohydrates (dextrose, maltodextrin) and whey protein. The effects of a supplement containing moderate protein and a low-CHO mixture on endurance performance has not been investigated. Also, the effects of CHO+PRO supplementation in the form of a natural food, flavored milk, on measures of recovery from acute endurance exercis

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