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Artykuły w czasopismach na temat „Jonathan Cott”

Autor: Grafiati
Data publikacji: 3 czerwca 2025
Data aktualizacji: 31 lipca 2025

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1

Gritter, Elizabeth. "Dinner with Lenny: The Last Long Interview with Leonard Bernstein. By Jonathan Cott." Oral History Review 43, no. 1 (2016): 228–30. http://dx.doi.org/10.1093/ohr/ohw032.

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Sasser, M. Tyler. "There’s a Mystery There: The Primal Vision of Maurice Sendak by Jonathan Cott." Children's Literature Association Quarterly 44, no. 1 (2019): 117–19. http://dx.doi.org/10.1353/chq.2019.0011.

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Helgert, Lars. "Dinner with Lenny: The Last Long Interview with Leonard Bernstein by Jonathan Cott." Notes 71, no. 1 (2014): 100–101. http://dx.doi.org/10.1353/not.2014.0078.

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Hunt, Peter. "Plus ça change … Issues Raised by a Reissue. Pipers at the Gates of Dawn: The Wisdom of Children's Literature. Jonathan Cott." International Research in Children's Literature 13, no. 2 (2020): 333–40. http://dx.doi.org/10.3366/ircl.2020.0362.

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Charru, Philippe. "Glenn Gould , Entretiens avec Jonathan Cott . Trad. de l’anglais (États-Unis) par J. Drillon. Les Belles Lettres, coll. Le goût des idées, 2012, 159 pages, 13 €." Études Tome 417, no. 9 (2012): XI. http://dx.doi.org/10.3917/etu.4173.0263k.

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Williams, Jim. "Dinner with Lenny: The Last Long Interview with Leonard Bernstein by Jonathan Cott, and: Creating Musical Theatre: Conversations with Broadway Directors and Choreographers by Lyn Cramer." Journal of Dramatic Theory and Criticism 29, no. 2 (2015): 182–85. http://dx.doi.org/10.1353/dtc.2015.0000.

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Doherty, David. "Conversations with Glenn Gould. By Jonathan Cott. University of Chicago Press, 1427 E. 60th St., Chicago, IL 60637; 800-621-2736; fax, 800-621-8476, www.press .chicago.edu. 2005. 160 pp. Black-and-white photographs, appendixes. Paperback, $15.00." Music Educators Journal 93, no. 2 (2006): 21. http://dx.doi.org/10.1177/002743210609300210.

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Roberts, Cheryl. "Jonathan Faiers, Fur: A Sensitive History." Costume 55, no. 2 (2021): 271–72. http://dx.doi.org/10.3366/cost.2021.0203.

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Wicks, TJ, and AR Granger. "Effects of low rates of pesticides on the control of pests and diseases of apples." Australian Journal of Experimental Agriculture 29, no. 3 (1989): 439. http://dx.doi.org/10.1071/ea9890439.

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Fungicides and insecticides used at the recommended rate, and reduced recommended rates were applied at low volume (100 L ha-1) to apple trees in field experiments in South Australia from 1985 to 1988. At harvest the incidence of fruit damaged by fungi and insects was assessed on Golden Delicious, Red Delicious, Jonathan and Granny Smith cultivars. Mixtures of penconazole and mancozeb applied at the recommended rates of 800 mL and 4.5 kg ha-1 respectively as well as 25% and 10% of the recommended rates controlled apple scab completely in 1986, but were less effective in 1987. Azinphos-methyl a
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Elliott, Jonathan. "Achieving cost- effective digital change in practice." Practice Management 33, no. 1 (2023): 38–42. http://dx.doi.org/10.12968/prma.2023.33.1.38.

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Jonathan Elliott calls for the NHS to embrace proven, UK developed digital solutions that build on existing NHS processes and systems that transform patient and clinician experience at a fraction of the cost and with minimal disruption
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Klein, Joan. "Dr. Jonathan E. Rhoads, Legendary Surgeon, Dies." Oncology Times 24, no. 2 (2002): 75. http://dx.doi.org/10.1097/01.cot.0000294278.26518.63.

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Taylor, Emily. "Colors in Fashion, ed. by Jonathan Faiers and Mary Westerman Bulgarella." Costume 52, no. 1 (2018): 136–38. http://dx.doi.org/10.3366/cost.2018.0053.

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Bouchard, Jonathan, Michael Hull, Ruthwik Anupindi, et al. "Treatment Patterns & Health Care Costs Among Patients With Stroke & Spasticity." American Journal of Occupational Therapy 77, Supplement_2 (2023): 7711510241p1. http://dx.doi.org/10.5014/ajot.2023.77s2-po241.

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Abstract Date Presented 04/22/2023 Patients with poststroke spasticity experienced higher mean health care costs than those with stroke without spasticity. Earlier identification to optimize treatment of spasticity represents an opportunity for cost savings in health care systems. Primary Author and Speaker: Jonathan Bouchard Contributing Authors: Michael Hull, Ruthwik Anupindi, Jing He, Mitchell DeKoven, Jumaah Goldberg, Jonathan Bouchard
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Crowhurst, Jonathan. "What Cost “Bad” Information?" Legal Information Management 6, no. 3 (2006): 208–11. http://dx.doi.org/10.1017/s1472669606000739.

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Bad information can have a number of undesired consequences for those people and organizations supplying it, whilst those affected by its provision have a number of legal remedies open to them. Jonathan Crowhurst discusses these issues after some definitions of information and bad information have been suggested. Concluding remarks suggest that information is not neutral, that bad information is largely down to lack of end user education and lack of investment in training, and that technology does not supply all the answers.
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Jago, Mark. "The cost of truthmaker maximalism." Canadian Journal of Philosophy 43, no. 4 (2013): 460–74. http://dx.doi.org/10.1080/00455091.2013.849059.

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According to truthmaker theory, particular truths are true in virtue of the existence of particular entities. Truthmaker maximalism holds that this is so for all truths. Negative existential and other ‘negative’ truths threaten the position. Despite this, maximalism is an appealing thesis for truthmaker theorists. This motivates interest in parsimonious maximalist theories, which do not posit extra entities for truthmaker duty. Such theories have been offered by David Lewis and Gideon Rosen, Ross Cameron, and Jonathan Schaffer. However, it will be argued here that these theories cannot be sust
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Cotts, Leonardo, Jonathan P. Slifkin, Ricardo Moratelli, Lucas Gonçalves, and Oscar Rocha-Barbosa. "Multiple colors in anteaters: review and description of chromatic disorders in Tamandua (Xenarthra: Pilosa) with reports of new and rare coat colorations." Zoologia 40 (March 13, 2023): 1–17. https://doi.org/10.1590/S1984-4689.v40.e22034.

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Cotts, Leonardo, Slifkin, Jonathan P., Moratelli, Ricardo, Gonçalves, Lucas, Rocha-Barbosa, Oscar (2023): Multiple colors in anteaters: review and description of chromatic disorders in Tamandua (Xenarthra: Pilosa) with reports of new and rare coat colorations. Zoologia (e22034) 40: 1-17, DOI: 10.1590/S1984-4689.v40.e22034, URL: http://dx.doi.org/10.1590/s1984-4689.v40.e22034
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Ballen, Fredy H., Edward Evans, Jonathan Crane, and Aditya Singh. "Sample Profitability and Cost Estimates of Producing Sweet Flavored Carambola (Averrhoa carambola) in south Florida." EDIS 2020, no. 3 (2020): 7. http://dx.doi.org/10.32473/edis-fe1079-2020.

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This 7-page fact sheet written by Fredy H. Ballen, Aditya Singh, Edward A. Evans, and Jonathan H. Crane and published by the UF/IFAS Food and Resource Economics Department reports the costs and returns of operating an established sweet-flavored carambola grove in south Florida. It is intended to provide a reference to help estimate the financial requirements of running an established grove. Information was collected through field interviews with growers and industry specialists about a wide range of production practices used on small farms of five acres or fewer
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Garcia, Stella, Edward Evans, and Jonathan Crane. "Cost Estimates of Establishing and Producing Thai Guavas in Florida, 2014." EDIS 2016, no. 8 (2016): 7. http://dx.doi.org/10.32473/edis-fe998-2016.

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The white Thai guava variety, which is very popular in the Asian market, is beginning to expand into mainstream markets. It has quick, high yields, is easily propagated, and is tolerant to moisture, stress, and soil salinity. But even though it offers favorable returns, there has been little information about the cost of production. This 7-page fact sheet identifies inputs, costs, and yields considered to be typical of a well-managed five-acre Thai guava orchard in south Florida. Written by Stella Garcia, Edward A. Evans, and Jonathan Crane, and published by the UF Department of Food and Resou
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Lee, Joan. "Reviewer Acknowledgements for Sustainable Agriculture Research, Vol. 6, No. 3." Sustainable Agriculture Research 6, no. 3 (2017): 117. http://dx.doi.org/10.5539/sar.v6n3p117.

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Sustainable Agriculture Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated.Sustainable Agriculture Research is recruiting reviewers for the journal. If you are interested in becoming a reviewer, we welcome you to join us. Please find the application form and details at http://www.ccsenet.org/reviewer and e-mail the completed application form to sar@ccsenet.org. Reviewers for Volume 6, Number 3Aftab Alam, United StatesAmi Lokha
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Conforti, Joseph. "Mary Lyon, the Founding of Mount Holyoke College, and the Cultural Revival of Jonathan Edwards." Religion and American Culture: A Journal of Interpretation 3, no. 1 (1993): 69–89. http://dx.doi.org/10.1525/rac.1993.3.1.03a00040.

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Recent studies of the Second Great Awakening have stressed the strong appeal of evangelical religion to female worshippers. The revival has been portrayed as a “women's awakening” that nurtured “bonds of womanhood,” promoted female benevolence, and shaped antebellum canons of domesticity. Mary Lyon (1797-1849) and the founding of Mount Holyoke Seminary, which opened in 1837, have not gone unnoticed by historians of a women's awakening. In a follow-up essay to her important study of Catherine Beecher, for example, Kathryn Kish Sklar established the educational significance of Mount Holyoke and
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Onyishi, Tony O., and Okechukwu Innocent Eme. "The Presidency and Cost of Governance in Nigeria : A Case of Jonathan’s Administration." Oman Chapter of Arabian Journal of Business and Management Review 3, no. 2 (2013): 1–24. http://dx.doi.org/10.12816/0002366.

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Bayer, Christian. "A Comment on the Economics of Labor Adjustment: Mind the Gap: Evidence from a Monte Carlo Experiment." American Economic Review 99, no. 5 (2009): 2258–66. http://dx.doi.org/10.1257/aer.99.5.2258.

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This comment addresses a point raised in Russell Cooper and Jonathan Willis (2003, 2004), which discusses whether the “gap approach” is appropriate to describe the adjustment of production factors. They show that this approach to labor adjustment as applied in Ricardo J. Caballero, Eduardo Engel, and John C. Haltiwanger (1997) and Caballero and Engel (1993) can falsely generate evidence in favor of nonconvex adjustment costs, even if costs are quadratic. Simulating a dynamic model of firm-level employment decisions with quadratic adjustment costs and estimating a gap model from the simulated d
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Kos, M., A. Mrhar, and M. Obradovic. "Response to the comments on ‘Cost-effectiveness of antipsychotics for outpatients with chronic schizophrenia’ by Steve S. Koh and Jonathan M. Meyer." International Journal of Clinical Practice 62, no. 7 (2008): 1119–20. http://dx.doi.org/10.1111/j.1742-1241.2008.01764_2.x.

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BAL, Metin. "THE PHILOSOPHICAL MEANING OF THE KILLING OF A SACRED DEER AS A CONTEMPORARY INTERPRETATION OF TRAGEDY IPHIGENIA AT AULIS." IEDSR Association 6, no. 15 (2021): 491–508. http://dx.doi.org/10.46872/pj.399.

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With the movie The Killing of a Sacred Deer , Jorgos Lanthimos takes the value sacred from superhuman powers and makes it mundane. It is claimed that queen Clytemnestra, one of the heroes of Euripides’ tragedy Iphigenia at Aulis, does not believe in superhuman powers. This is because Clytemnestra considers the event of killing of her own daughter Iphigenia a murder rather than a sacrifice. In The Killing of a Sacred Deer, Lanthimos interprets the killing of Iphigenia as a “sacrifice” by her own father, King Agamemnon, to question the relations between the people of the contemporary world. Are
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Judy, Jonathan D., Maria L. Silveira, Sampson Agyin-Birikorang, George O'Connor, and Thomas A. Obreza. "Drinking Water Treatment Residuals to Control Phosphorus in Soils." EDIS 2019 (August 21, 2019): 6. http://dx.doi.org/10.32473/edis-ss513-2019.

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Soils in Florida may contain excess soil phosphorus (P) resulting from fertilizer, manure or biosolids applications. Excess P in soil does not damage soil fertility but can be transported from agricultural and urban areas either dissolved in water that drains away or as particulate matter (attached to soil particles) that travels with eroding soil. Increased P in water bodies is recognized as one of the major factors responsible for eutrophication-related decrease in water quality. Most soils have the capacity to retain excess P. However, soils with low capacity to retain excess P are abundant
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Henigman, Laura. "Stowe and Her Foremothers: The Newport Female Society in The Minister's Wooing." Prospects 30 (October 2005): 135–55. http://dx.doi.org/10.1017/s0361233300002015.

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The publication of The Minister's Wooing in 1859 marked a turn in Harriet Beecher Stowe's fictional output. Having published two antislavery novels earlier in the decade, the first of which, of course, made her an international celebrity, she turned to what we think of now as the next phase of her writing career, a series of nostalgic, partly autobiographical novels about historic New England, following Minister's Wooing with The Pearl of Orr's Island (1862), Oldtown Folks (1978), and Poganuc People (1878).Set in 18th-century Newport, Rhode Island, The Minister's Wooing is built around the his
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Okey, Ogar, Timothy, Etim, Emmanuel Asuquo, and Ayuk Simon Obietta. "Flood Risk Zones, Housing Development and Response of Residential Property Owners in Calabar Metropolis, Nigeria." International Research Journal of Innovations in Engineering and Technology 06, no. 09 (2022): 09–17. http://dx.doi.org/10.47001/irjiet/2022.609002.

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The study examined flood risk zones as ecological constraint to housing development and the response of residential property owners in the Calabar metropolis, Nigeria. Multi-research design was used to map flood risk zones. The continuous data types include satellite imageries, digital elevation model, distance to river and administrative boundary data made up secondary data. Primary data include questionnaires administered to 400 respondents based on the Taro Yamane sample size formula and multi criteria analysis was adopted to select flood prone zones. Findings revealed that places such as M
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Ajiteru,S.A.R, Sulaiman T.H, and Abalaka, J.N. "Nigerian Public Sector Governance Costs in the Era of President Muhammadu Buhari : an Administrative Perspective." Digital Innovation : International Journal of Management 2, no. 2 (2025): 80–98. https://doi.org/10.61132/digitalinnovation.v2i2.289.

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The declaration by President Muhammadu Buhari that he is willing to reduce the rising expenses of managing public affairs is a major surprise. Newspapers everywhere have stated that he will face the confront the problem head-on by reforming numerous government agencies, merging others, and dismantling others. We are still figuring out the specifics. The only information that has been made public thus far is that the plan's first casualties will be the Universal Tertiary Matriculation Examination, the National Examinations Council, and the National Poverty Eradication Programme. It is evident f
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Laberge, Yves. "Les cultures régionales du sud et leurs mutations dans la musique américaine au 20e siècle : Blind Willie Johnson, Robert Crumb, Bob Dylan, et John FogertyHéros du blues, du jazz et de la country, par Robert Crumb. Paris, Editions de La Martinière, 2008. 240 pp. €19,95 (couverture rigide).Revelation Blind Willie Johnson The Biography: The Man, The Words, The Music, by D. N. Blakey. Raleigh, Caroline du Nord, Lulu Press, 2007. 322 pp. $25,22 EU (poche).Dylan par Dylan: Interviews 1962-2004, par Bob Dylan, Jonathan Cott, et Denis Griesmar. Paris, Bartillat, 2007. 560 pp. €30,00 (poche).Bad Moon Rising: The Unauthorized History of Creedence Clearwater Revival, by Hank Bordowitz. Chicago, Illinois, Chicago Review Press, 2007. 400 pp. $16,95 EU (poche)." Canadian Journal of History 45, no. 2 (2010): 347–52. http://dx.doi.org/10.3138/cjh.45.2.347.

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Zhang, Connie, Katarzyna Zientara-Rytter, Moji Samoudi, et al. "Abstract 5457: Dual-antigen bridging ELISAs to validate bispecific molecules with CD3-directed T cell engager function." Cancer Research 85, no. 8_Supplement_1 (2025): 5457. https://doi.org/10.1158/1538-7445.am2025-5457.

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Bispecific antibodies (bsAbs), designed to recognize two distinct antigens or epitopes, represent a promising class of next-generation biological therapeutics. These macromolecules, capable of engaging multiple targets, have gained significant interest over the past decade for their potential to harness the immune system against specific targets. With additive or synergistic mechanisms of action, bsAbs and other engineered dual-targeting molecules often exhibit greater potency than monoclonal antibodies (mAbs) or combination therapies. By simultaneously bridging two targets, bsAbs provide addi
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Lee, Joan. "Reviewer Acknowledgements for Sustainable Agriculture Research, Vol. 7, No. 1." Sustainable Agriculture Research 7, no. 1 (2018): 156. http://dx.doi.org/10.5539/sar.v7n1p156.

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Sustainable Agriculture Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated.Sustainable Agriculture Research is recruiting reviewers for the journal. If you are interested in becoming a reviewer, we welcome you to join us. Please find the application form and details at http://www.ccsenet.org/reviewer and e-mail the completed application form to sar@ccsenet.org. Reviewers for Volume 7, Number 1Aftab Alam, Vice President Agricul
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Lee, Joan. "Reviewer Acknowledgements for Sustainable Agriculture Research, Vol. 7, No. 4." Sustainable Agriculture Research 7, no. 4 (2018): 134. http://dx.doi.org/10.5539/sar.v7n4p134.

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Sustainable Agriculture Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated.
 
 Sustainable Agriculture Research is recruiting reviewers for the journal. If you are interested in becoming a reviewer, we welcome you to join us. Please find the application form and details at http://www.ccsenet.org/journal/index.php/sar/editor/recruitment and e-mail the completed application form to sar@ccsenet.org.
 
 &nb
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Wailer, Rich. "Influence of Historical Events on American Literature of the 21st Century." American Journal of Literature Studies 3, no. 2 (2024): 34–44. http://dx.doi.org/10.47672/ajls.2317.

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Purpose: The aim of the study was to assess the influence of historical events on American literature of the 21st century. Materials and Methods: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries. Findings: The terrorist attacks marked a significant turning po
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Smith-Salzberg, Bayle, Joshua Feinberg, Pasang Sherpa, et al. "Abstract P1-06-13: Financial Toxicity and Quality of Life in Breast Cancer Patients at a Safety Net Hospital." Clinical Cancer Research 31, no. 12_Supplement (2025): P1–06–13—P1–06–13. https://doi.org/10.1158/1557-3265.sabcs24-p1-06-13.

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Abstract Introduction: Financial toxicity (FT) is the burden faced from out-of-pocket expenses related to cancer treatment, including direct cost of treatments, lost income, and travel expenses. Studies suggest increased FT is associated with decreased quality of life (QOL) and, possibly, worse survival. Patients from potentially marginalized groups including non-English speakers or patients with low socioeconomic status may be particularly vulnerable to FT. Maimonides Medical Center (MMC) is a safety net hospital in Brooklyn, NY, that treats many such patients. Here we present preliminary dat
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Aung, Thazin Nwe, Tianci Song, Lajos Pusztai, Mark Gerstein, David L. Rimm, and Jonathan H. Warrell. "Abstract 2424: Integrating digital spatial profiling and H&E images to develop predictive biomarkers for immunotherapy outcomes in triple-negative breast cancer from imputed spatial gene expression." Cancer Research 85, no. 8_Supplement_1 (2025): 2424. https://doi.org/10.1158/1538-7445.am2025-2424.

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Abstract Introduction: Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognoses and limited biomarkers for predicting treatment outcomes [1]. Tumor-infiltrating lymphocytes and PD-L1 expression, while associated with immune checkpoint inhibitor (ICI) efficacy, fail to predict responses reliably [2, 3]. Spatial transcriptomics is a cutting-edge technology that enables the precise mapping of gene expression within tissue samples. However, the high cost of sequencing limits its clinical utility. This study aims to develop cost-effective predictive biomarkers by integratin
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Wu, Zhong, Michelle Baird, Cornelia Mechlen, Peter Hahn, and Jonathan M. Shaffer. "Abstract 320: Development and automation of a streamlined targeted enrichment method for cancer mutation detection." Cancer Research 84, no. 6_Supplement (2024): 320. http://dx.doi.org/10.1158/1538-7445.am2024-320.

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Abstract Next Generation Sequencing (NGS) of DNA is a powerful tool for the detection of genetic variations, including single nucleotide polymorphisms, copy number variation, and small insertions/deletions. Target enrichment technologies enhance DNA sequencing by enabling users to analyze specific regions of interest only, which helps to effectively increase sequencing depth and sample throughput while minimizing cost. However, many targeted DNA library construction workflows are not optimal for routine genetic testing needs due to inconsistent, lengthy workflow. This poses significant challen
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Castillo-Fernandez, Omar, Cristiane Martin, Maria Lim, et al. "Abstract P4-06-11: What do patients, doctors, and payers truly value? Developing a multi-criteria decision analytic tool that assesses the value of adjuvant hormonal plus CDK inhibitors in breast cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): P4–06–11—P4–06–11. https://doi.org/10.1158/1557-3265.sabcs24-p4-06-11.

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Abstract Background: Multicriteria Decision Analysis (MCDA) is a collaborative process that helps clinicians, payers, and patients consider various factors such as treatment effectiveness, potential side effects, cost, individual preferences, and quality of life outcomes. This study aims to evaluate the agreement among patients, doctors, and payers regarding the factors used to assess interventions for adjuvant CDK inhibitors and hormonal therapy in breast cancer in our country. Methods: To create the rating instrument, we formed three groups – The patient group: 15 patients with non-metastati
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Feder, Judy. "Sour-Service Risers and Accessories for HP/HT Application in the Gulf of Mexico." Journal of Petroleum Technology 73, no. 03 (2021): 60–61. http://dx.doi.org/10.2118/0321-0060-jpt.

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This article, written by JPT Technology Editor Judy Feder, contains highlights of paper OTC 30558, “Development and Implementation of Heavy-Wall, High-Strength, Sour-Service Accessory and Risers for HP/HT Application in the Gulf of Mexico,” by Carine Landier, Jonathas Oliveira, and Christelle Gomes, Vallourec, et al., prepared for the 2020 Offshore Technology Conference, originally scheduled to be held in Houston, 4–7 May. The paper has not been peer reviewed. Copyright 2020 Offshore Technology Conference. Reproduced by permission. As oil and gas development in the Gulf of Mexico increasingly
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Vora, Haily, Ramez Ibrahim, Chan Johanna, Francis Farraye, and Jana Al Hashash. "THE UTILITY OF BIOPSYING ENDOSCOPICALLY NORMAL APPEARING TERMINAL ILEUM." Inflammatory Bowel Diseases 29, Supplement_1 (2023): S13—S15. http://dx.doi.org/10.1093/ibd/izac247.028.

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Abstract INTRODUCTION The terminal ileum is often evaluated during colonoscopy procedures. A common indication for endoscopic examination and biopsy of an endoscopically normal appearing terminal ileum is in patients with inflammatory bowel disease (IBD). 1 In patients without IBD, indications for biopsying an endoscopically normal appearing terminal ileum are less clear and may be associated with increased cost and healthcare utilization, as well as increased levels of anxiety for patients. In this study, we aim to determine the indications for examining and biopsying an endoscopically normal
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Nahhas, Omar S. El, Joseph D. Bonner, Joel K. Greenson, et al. "Abstract LB386: Weakly-supervised prediction of tumor infiltrating lymphocytes per high power field from colorectal cancer histopathology slides using regression transformers." Cancer Research 84, no. 7_Supplement (2024): LB386. http://dx.doi.org/10.1158/1538-7445.am2024-lb386.

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Abstract Tumor infiltrating lymphocytes (TILs)-based biomarkers have emerged as a robust method for predicting treatment efficacy and outcome in colorectal cancer (CRC). However, the quantification of TILs remains a strenuous task for pathologists and is susceptible to inter-pathologist variations. Deep learning (DL) can predict cancer biomarkers directly from routine hematoxylin and eosin (H&E) pathology slides, enabling the automated and consistent quantification of TILs for clinical decision-making. Our study focuses on the prediction of TILs per high-power field (HPF) on two large coho
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Simpson, Thomas J. "Response to “Neonatal Viability in the 1990s: Held Hostage by Technology” by Jonathan Muraskas et al. and “Giving ‘Moral Distress’ a Voice: Ethical Concerns among Neonatal Intensive Care Unit Personnel” by Pam Hefferman and Steve Heilig (CQ Vol 8, No 2)." Cambridge Quarterly of Healthcare Ethics 8, no. 4 (1999): 524–26. http://dx.doi.org/10.1017/s0963180199004144.

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Muraskas et al. and Hefferman and Heilig present the painfully elusive ethical questions regarding decisionmaking in the care of the extremely low birth weight (ELBW) infants in the intensive care nursery. At what gestation or size do we resuscitate? Can we stop resuscitation after we have started? How much money is too much to spend? Is the distress of the parents of the ELBW infant, the anguish of their caregivers, and the moral and ethical uncertainty of the approach to these infants too much to pay? Who speaks for the neonate: the parent, nurse, attorney, or physician? Ideally these questi
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Kennedy, Jonathan, Sarah M. Leiter, Angus Hodder, et al. "Abstract B011: Whole genome sequencing can reproduce all standard-of-care diagnostics for childhood cancer: Results from two national systems." Cancer Research 84, no. 17_Supplement (2024): B011. http://dx.doi.org/10.1158/1538-7445.pediatric24-b011.

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Abstract BACKGROUND Whole genome sequencing (WGS) is the most informative singular molecular assay in cancer diagnosis. Recent evidence demonstrates that WGS can add diagnostic information and change the management of childhood cancer, and thus is being increasingly employed in clinical settings globally. However, it remains unknown whether WGS can accurately recapitulate existing multi-assay standard-of-care (SOC) genomic testing used in pediatric cancer diagnostics. In this study we evaluate the concordance between WGS and SOC findings from an unselected cohort of children across 8 centres f
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Maier, Keith E., Vishnu U. Sunitha Kumary, Bryan J. Venters, et al. "Abstract 7027: Direct multi-omics for the masses: Linking DNA methylation to chromatin targets via TEM-seq." Cancer Research 84, no. 6_Supplement (2024): 7027. http://dx.doi.org/10.1158/1538-7445.am2024-7027.

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Abstract DNA methylation (DNAme) is an epigenetic mark that includes the modification of cytosine resides (5mC) within CpG islands. In addition to well characterized roles regulating gene expression, imprinting and silencing parasitic DNA elements, the misregulation of DNAme is implicated in multiple diseases. Evidence is emerging that DNAme is not an independent epigenetic mark but rather closely linked to the post translational modification (PTM) of histone proteins. However, examining the relationship between 5mC and PTMs are hampered by the usual approach of independent analyses that canno
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Albin, Maurice S. "In praise of anesthesia: Two case studies of pain and suffering during major surgical procedures with and without anesthesia in the United States Civil War-1861–65." Scandinavian Journal of Pain 4, no. 4 (2013): 243–46. http://dx.doi.org/10.1016/j.sjpain.2013.07.028.

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AbstractBackgroundThe United States Civil War (1861–1865) pitted the more populous industrialized North (Union) against the mainly agricultural slaveholding South (Confederacy). This conflict cost an enormous number of lives, with recent estimates mentioning a total mortality greater than 700,000 combatants [1]. Although sulfuric ether (ETH) and chloroform (CHL) were available since Morton’s use of the former in 1846 and the employment of the latter in 1847, and even though inhalational agents were used in Crimean war (1853–1856) and the Mexican-American War (1846–1848), the United States Civi
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Tanaka, Hiromi, Shuo Shen, Mauro Scimia, et al. "Abstract 6505: ColoScape test: a molecular assay to detect early-stage colorectal cancer in plasma cell-free DNA." Cancer Research 83, no. 7_Supplement (2023): 6505. http://dx.doi.org/10.1158/1538-7445.am2023-6505.

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Abstract Colorectal cancer (CRC) is the second most common cause of cancer deaths when men and women are combined in the U.S. Early detection in the precancerous stage is key to reducing the CRC morbidity and mortality rates. Thus, there is a critical need for a cost-effective, time-efficient, and convenient clinical tool for early CRC detection. We have developed a multiplex qPCR assay (ColoScapeTM) to detect CRC-associated genetic and epigenetic changes from liquid biopsy samples (i.e., cell-free DNA) using our proprietary QClamp® XNA technology. The QClamp® XNA technology is very unique and
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Sonnenschein, Anne, Maysun Hasan, Sandra Hui, et al. "Abstract 2324: Leveraging a comprehensive genomic data library for detecting clonal hematopoiesis in liquid biopsy." Cancer Research 84, no. 6_Supplement (2024): 2324. http://dx.doi.org/10.1158/1538-7445.am2024-2324.

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Abstract Background: Clonal Hematopoiesis (CH) is a well established confounder in next-generation sequencing (NGS)-based liquid biopsy cancer diagnostics. Misclassification of CH variants as tumor variants can lead to false positive actionable variant detection, potentially resulting in incorrect interpretation of results and therapy selection. Moreover, CH variants may also interfere with quantitative variant monitoring leading to inaccurate assessment of treatment response. While filtering of CH variants is possible via matched sequencing of white blood cell and plasma DNA, emerging algorit
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Harrop, Ben, Anna Halajko, and Glenn G. Amatucci. "Tailored Iron Fluoride Lattices and Nanocomposites for High Energy, Rate, and Long Cycle Life." ECS Meeting Abstracts MA2024-02, no. 7 (2024): 908. https://doi.org/10.1149/ma2024-027908mtgabs.

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Due to the rapidly growing energy demands of portable electronics, electric vehicles and grid storage, the need for efficient, energy dense secondary batteries is more important than ever before. Current commercial lithium batteries generally use a layered transition metal oxide, such as LiCoO2 (LCO), which is an intercalation positive electrode that has a theoretical capacity of 274mAh/g, but a practical capacity of only 140-160 mAh/g (3). Current graphite negative electrode capacities are approximately 300mAh/g (4), lithium metal has a capacity of 3860mAh/g (5), and newly incorporated Si all
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Ismail, Mohamed (Soly) Soliman, Jonathan Tart, Gareth Davies та ін. "Abstract B016: High throughput application of the NanoBiT Biochemical Assay for the discovery of selective p110α isoform binders that block its interaction with KRAS". Molecular Cancer Research 21, № 5_Supplement (2023): B016. http://dx.doi.org/10.1158/1557-3125.ras23-b016.

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Abstract RAS proteins contribute to the activation of p110α by directly interacting with its RAS binding domain (RBD), resulting in the promotion of cellular functions such as cell growth, proliferation and survival. Previously, we have shown that blocking the interaction of p110α with oncogenic RAS, by introducing specific mutations in the RBD, had a significant impact on tumor initiation and growth in mouse models, whilst having little effect on the health of normal adult mice. These studies highlight the significance of the p110α/KRAS protein-protein interaction (PPI) in tumor progression a
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Ismail, Mohamed (Soly) Soliman, Julian Downward, Jonathan Tart та ін. "Abstract C038: High throughput application of the NanoBiT Biochemical Assay for the discovery of selective p110α isoform binders that block its interaction with KRAS". Molecular Cancer Therapeutics 22, № 12_Supplement (2023): C038. http://dx.doi.org/10.1158/1535-7163.targ-23-c038.

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Abstract RAS proteins contribute to the activation of p110α by directly interacting with its RAS binding domain (RBD), resulting in the promotion of cellular functions such as cell growth, proliferation and survival. Previously, we have shown that blocking the interaction of p110α with oncogenic RAS, by introducing specific mutations in the RBD, had a significant impact on tumor initiation and growth in mouse models, whilst having little effect on the health of normal adult mice. These studies highlight the significance of the p110α/KRAS protein-protein interaction (PPI) in tumor progression a
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Serafin, Robert B., Jennifer Salguero-Lopez, Rui Wang, et al. "Abstract 2435: Automatic detection of prostate cancer in 3D pathology datasets based on synthetic immunolabeling of cytokeratins." Cancer Research 85, no. 8_Supplement_1 (2025): 2435. https://doi.org/10.1158/1538-7445.am2025-2435.

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Abstract For AI-analysis of 3D pathology datasets, delineating benign and cancerous tissue regions is often a critical first step. For prostate cancer (PCa) this can be challenging due to the complex intermixing of benign and cancerous glands in 3D. Automated detection of cancerous glands could improve the efficiency and accuracy of downstream computational tasks, such as risk stratification using 3D histomorphometric features. For example, we previously developed machine classifiers based on 3D glandular and nuclear morphologies in PCa biopsies but relied on pathologists to manually identify
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