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Rozprawy doktorskie na temat „Keratitis”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Sueke, Henri. "Novel approaches in bacterial keratitis." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2006499/.

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Bacterial keratitis is a serious ophthalmic disease with significant visual morbidity. The aims of this thesis are to investigate (1) the prevalence and type of bacterial virulence factors in the two major species causing keratitis; Staphylococcal aureus and Pseudomonas aeruginosa and (2) the pharmacodynamics and pharmacokinetics of meropenem, a potentially novel antimicrobial for use in keratitis. The prevalence, genetic diversity and clinical relevance of the lukSF-PV gene, encoding the bacterial toxin Panton Valentine Leukocidin, were investigated in S. aureus, isolated from cases of bacter

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2

Klocke, Julia. "Spontane bakterielle Keratitis in CD36-/- Knockout- Mäusen." Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-87190.

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PURPOSE. CD36 is a Class B scavenger receptor that is constitu- tively expressed in the corneal epithelium and has been impli- cated in many homeostatic functions, including the homeosta- sis of the epidermal barrier. The aim of this study is to determine (1) whether CD36 is required for the maintenance of the corneal epithelial barrier to infection, and (2) whether CD36-deficient mice present with an increased susceptibility to bacterial keratitis. METHODS. The corneas of CD36- /- , TSP1- /- , TLR2- /- , and C57BL/6 WT mice were screened via slit lamp microscopy or ex vivo analysis. The epith

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3

Clarke, Daniel William. "The pathogenic cascade of Acanthamoeba Keratitis." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=153.

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4

Otri, Ahmad Muneer. "Infectious keratitis : a molecular and clinical study." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13408/.

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Infectious keratitis is a sight threatening disease which can cause permanent visual loss if not diagnosed and treated at an early stage. It can be caused by different types of microbes which are either commensals or transferred from the environment. To fight against these threats, the ocular surface (OS) has developed innate and adaptive immune mechanisms. Antimicrobial peptides (AMPs) are natural effectors on the OS with actions that range from microbicidal effects to cell signalling. Human beta defensin (hBD) 1-3 and 9, Liver expressed antimicrobial peptide (LEAP) 1 and 2, human cathelicidi

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5

Schubert, Tracey Lee Optometry &amp Vision Science Faculty of Science UNSW. "Increasing the ability of antibiotics to control S. aureus keratitis." Publisher:University of New South Wales. Optometry & Vision Science, 2008. http://handle.unsw.edu.au/1959.4/41516.

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Microbial keratitis is a major cause of avoidable visual impairment worldwide with S. aureus a leading cause of this disease in humans. Recently S. aureus isolated from eye infections have exhibited resistance to many antibiotics with those isolates from more severe infections exhibiting higher rates of antibiotic resistance. New therapies are therefore needed to ensure adequate treatment for these infections. In microbial keratitis the hosts' immune response is responsible for significant disease pathology so development of a therapy which also targets the immune response would be beneficial.

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6

Dart, John Kenneth George. "Contact lens related ulcerative keratitis : epidemiology and pathogenesis." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293396.

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7

Kozariychuk, N. Ya. "Approaches to recurrent meta-herpetic keratitis therapeutic treatment." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18633.

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8

Keay, Lisa Jane Optometry &amp Vision Science Faculty of Science UNSW. "Public health impact of contact lens related microbial keratitis." Awarded by:University of New South Wales. School of Optometry and Vision Science, 2006. http://handle.unsw.edu.au/1959.4/26307.

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This thesis describes the impact of contact lens-related microbial keratitis in terms of incidence and severity. Disease outcome is defined by visual outcome, costs to the healthcare system, costs to the individual and duration of disease. A successful 12-month surveillance study was conducted of the populations of Australia and New Zealand to detect all cases of contact lens-related microbial keratitis. A random telephone survey of 32,000 households in Australia and 7,500 in New Zealand accurately determined the level of use of various contact lenses in the community. The impact of new c

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9

Williams, David Leonard. "Canine chronic superficial keratitis : histochemical characterisation and clinical management." Thesis, Royal Veterinary College (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307438.

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10

Lee, Ming Yang. "Allele-specific siRNA therapy for keratitis-ichthyosis-deafness syndrome." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10052698/.

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Dominant mutations in the gene GJB2 cause keratitis-ichthyosis-deafness (KID) syndrome, a severe condition affecting the skin, cornea and inner ear. GJB2 encodes the protein connexin-26 (Cx26) which forms hemichannels or gap junction channels allowing the passage of signalling molecules. Approximately 80% of KID syndrome patients carry a c.148G > A (p.D50N) mutation in GJB2, which results in aberrant channel function. We hypothesised that silencing of the mutant allele in patient keratinocytes using allele-specific siRNA could correct the channel function. First, to confirm whether patient ker

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11

Fesser, Nicole. "Die Strahlentherapie der Keratitis superficialis chronica mit weichen Röntgenstrahlen /." Berlin : Mbv, 2008. http://d-nb.info/98997829X/04.

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12

Maberly, James. "Evaluating Severity of Microbial Keratitis Using Optical Coherence Tomography." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/26884.

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Microbial keratitis (MK) is an infection of the cornea caused a variety of pathogens that can lead to significant visual loss. The current diagnosis relies on clinical examination and microbiological testing. New in-vivo imaging techniques are now available that can assist the diagnosis and follow the clinical course of this disease. Using optical coherence tomography (OCT) it is possible to obtain high resolution imaging for the cornea. The purpose of this thesis is to demonstrate a link between the latest OCT technology and clinical outcomes by using a severity index scoring tool. A pr

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13

Chang, Eddie. "The role of perforin and chemokines in the pathogenesis of chronic corneal inflammation induced by herpes simplex virus type-1 infection." free to MU Campus, others may purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091911.

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14

Liu, Lei. "Immunology of herpes simplex keratitis and its treatment by corneal transplantation." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Online version available for University member only until Sep. 7, 2010, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=33585.

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15

Halenda, Ruth Marrion. "Moraxella bovis cytotoxin and cell detachment factor /." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9901239.

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16

Harney, B. A. "Investigations of a subunit vaccine in experimental herpes simplex keratitis." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375020.

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17

Chidambaram, J. D. "Studies in the diagnosis and pathophysiology of severe microbial keratitis." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2018. http://researchonline.lshtm.ac.uk/4649231/.

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Background: Microbial keratitis (MK) is a major cause of blindness worldwide. Few studies have assessed the HRT3 in vivo confocal microscope (IVCM) in the diagnosis or management of MK. This PhD aimed to investigate these questions and was based in a high incidence setting for MK: Aravind Eye Hospital, Madurai, India. Methods: A prospective observational study of 252 severe MK patients was conducted with follow-up at days 7, 14 and 21 post-enrolment. Quantitative PCR of corneal swabs obtained at presentation validated transcriptome results. IVCM images were evaluated in this cohort for diagnos

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18

Kozariichuk, N. Ya. "Certain therapeutic approaches to meta-herpetic keratitis treatment: case report." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18144.

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19

Köhlein, Sophie. "Stellenwert der PCR zur Diagnostik von Keratitis und Uveitis anterior." kostenfrei, 2008. http://mediatum2.ub.tum.de/doc/633320/633320.pdf.

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20

Green, Matthew Optometry &amp Vision Science Faculty of Science UNSW. "Epidemiology, microbiology, outcomes and trends in keratitis in Queensland 1999-2004." Awarded by:University of New South Wales. Optometry & Vision Science, 2007. http://handle.unsw.edu.au/1959.4/40595.

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AIMS 1. To establish the patient demographics, risk factors, causative organisms, levels of antibiotic resistance, clinical presentations and treatment patterns of keratitis at a tertiary referral hospital in Australia. 2. To establish any change in these factors over 5 years. 3. Establish the factors associated with poor outcomes. METHODS: A retrospective audit of all patients who had a corneal culture in 5 years was conducted. Patients' clinical information was gathered from medical records and smear, culture and antibiotic resistance results were gathered from the local microbiology databa

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21

Fesser, Nicole [Verfasser]. "Die Strahlentherapie der Keratitis superficialis chronica mit weichen Röntgenstrahlen / Nicole Fesser." Berlin : Freie Universität Berlin, 2008. http://d-nb.info/1023095963/34.

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22

Fahy, Gerald Thomas. "Alterations in Langerhans cells in the cornea during herpes simplex keratitis." Thesis, University of Bristol, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240031.

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23

Edwards, Catherine Patrice Optometry &amp Vision Science Faculty of Science UNSW. "The incidence of and risk factors for contact lens related microbial keratitis in Australia and New Zealand." Publisher:University of New South Wales. Optometry & Vision Science, 2008. http://handle.unsw.edu.au/1959.4/41406.

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Microbial keratitis is the most serious, and only potentially blinding complication of contact lens wear. To further understand and reduce the risk of this disease, incidence rates and risk factors have been estimated in numerous studies. Since these studies were conducted, new lens types have been introduced designed to reduce the risk of infection. It was hypothesised that the issues of contact lens related hypoxia and poor lens hygiene could be addressed by the introduction of silicone hydrogel and daily disposable lenses respectively. This thesis describes the incidence of and risk factor

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24

Elsahn, Ahmad. "Interactions between Pseudomonas aeruginosa bacteria and corneal fibroblasts in human microbial keratitis." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/411240/.

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Microbial keratitis (MK) is a leading cause of blindness in the developing world. Pseudomonas aeruginosa (PA) is the most common pathogen isolated from contact lens related MK, and is usually associated with significant visual complications. The intact corneal epithelium forms a strong barrier to bacterial penetration into deeper tissue, and only when bacteria reach the stroma, through a breach in the epithelium, does a typical ulcer develop, with stromal suppuration and necrosis. Since corneal fibroblasts are one of the most prominent cellular components in the stroma, they probably have an i

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25

Leal, Sixto M. Jr. "Fungal Keratitis: Immune Recognition, Neutrophil-Hyphae Interactions and Fungal Anti-Oxidative Defenses." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1339081455.

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26

Karmakar, Mausita. "INFLAMMASOME DEPENDENT AND INDEPENDENT IL-1BETA PROCESSING BY NEUTROPHILS DURING BACTERIAL KERATITIS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1396544303.

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27

Stapleton, Fiona J. "The pathogenesis and epidemiology of contact lens related disease in cosmetic contact lens wearers." Thesis, City University London, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280544.

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28

Lin, Michelle. "Facilitation of neutrophil migration through the corneal stroma during keratitis-Mmp8 and chemokines." Connect to text online, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1191012168.

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29

Lin, Michelle. "Facilitation of Neutrophil Migration Through the Corneal Stroma During Keratitis - Mmp8 and Chemokines." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1191012168.

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30

Cabrera, Aguas Maria Paulina. "Development, implementation and evaluation of evidence-based treatment guidelines for herpes simplex keratitis." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21845.

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Introduction Herpes simplex keratitis (HSK) is one the major causes of unilateral blindness in the developed world. Evidence-based recommendations for HSK had not been properly translated into practice. The overall aim of this thesis was to develop, implement, and evaluate a local HSK treatment guideline at the Sydney Eye Hospital. Methods The Registered Nurses’ Association of Ontario (RNAO) Toolkit: ‘Implementation of Best Practice Guidelines’ was utilised to develop, implement, and evaluate the guideline at the Hospital. A retrospective review was conducted to determine the knowledge gap. Al

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31

Pereira, Aline Cardoso. "Avaliação clínica e histopatológica do polímero poli(butileno adipato-co-tereftalato) (PBAT) em córnea de coelhos e aplicação no tratamento de úlceras de córnea em cães." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/154797.

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Submitted by Aline Cardoso Pereira (aline.cardosopereira@hotmail.com) on 2018-08-02T22:27:37Z No. of bitstreams: 1 DISSERTAÇÃO DE MESTRADO - ALINE C. PEREIRA.pdf: 2161021 bytes, checksum: 07880c29666b475277e0461208a4bf5a (MD5)<br>Approved for entry into archive by Isabel Pereira de Matos (isabel@fmva.unesp.br) on 2018-08-03T18:51:33Z (GMT) No. of bitstreams: 1 pereira_ac_me_araca_int.pdf: 2161021 bytes, checksum: 07880c29666b475277e0461208a4bf5a (MD5)<br>Made available in DSpace on 2018-08-03T18:51:33Z (GMT). No. of bitstreams: 1 pereira_ac_me_araca_int.pdf: 2161021 bytes, checksum: 07880c

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32

Chen, Yingxin, Weijia Yang, Minghong Gao, Michael Wellington Belin, Hai Yu, and Jing Yu. "Experimental study on cryotherapy for fungal corneal ulcer." Springer, 2015. http://hdl.handle.net/10150/610295.

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BACKGROUND: Fungal corneal ulcer is one of the major causes of visual impairment worldwide. Treatment of fungal corneal ulcer mainly depends on anti-fungal agents. In the current study, we developed an integrated combination therapy of cryotherapy and anti-fungal agents to facilitate effective treatment of fungal corneal ulcer. METHODS: Rabbit models of cornea infection were established using a combined method of intrastromal injection and keratoplasty. After treatment with cryotherapy and anti-fungal agents, scanning electron microscopy, transmission electron microscopy, and confocal microsco

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33

Denk, Nora. "Der Effekt UV-blockierender Kontaktlinsen bei der Therapie der Keratitis superficialis chronica des Hundes." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-106023.

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34

Makdoumi, Karim. "Ultraviolet light A (UVA) photoactivation of riboflavin as a potential therapy for infectious keratitis." Doctoral thesis, Örebro universitet, Hälsoakademin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-20130.

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35

Jordan, Lisa [Verfasser]. "Vorkommen von CaHV-1 bei Hunden mit Konjunktivitis, Keratitis und normalen Augenbefunden / Lisa Jordan." Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1231276045/34.

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36

Panatieri, Lua Ferreira. "Avaliação da atividade amebicida de nanoemulsões contendo extrato hexânico de Pterocaulon balansae (Asteraceae) frente à Acanthamoeba sp." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/149471.

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O tratamento da ceratite por Acanthamoeba é longo, inespecífico e de baixa adesão do paciente. Assim, a busca por novas estratégias de tratamento é necessária. Extratos não aquosos de algumas espécies de Pterocaulon exibem efeito antimicótico e antiparasitário, sendo esta atividade correntemente relacionada à presença de cumarinas. Neste contexto, o presente estudo teve por objetivo o desenvolvimento de nanoemulsões contendo extrato hexânico de Pterocaulon balansae Chodat (rico em cumarinas) visando à obtenção de um produto de uso ocular com atividade amebicida. Em uma primeira etapa, o extrat

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37

Klocke, Julia [Verfasser], Peter [Akademischer Betreuer] Wiedemann, and unbekannt [Gutachter] unbekannt. "Spontane bakterielle Keratitis in CD36-/- Knockout- Mäusen / Julia Klocke ; Gutachter: unbekannt unbekannt ; Betreuer: Peter Wiedemann." Leipzig : Universitätsbibliothek Leipzig, 2012. http://d-nb.info/1238076793/34.

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38

Banjo, Taiwo Abayomi. "Acanthamoeba mannose-binding protein : structural and functional characterisation of a therapeutic target for Acanthamoeba keratitis." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42327.

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Acanthamoeba mannose-binding protein (AcMBP) is a virulence factor of the free-living amoeba, Acanthamoeba castellanii. It is crucial for the development of Acanthamoeba keratitis (AK), a corneal infection that often causes blindness. AK is associated with contact lens use and contaminated water sources. Therapeutic unresponsiveness is attributed to similarities in the biological processes that Acanthamoeba shares with humans and its ability to form drug-resistant cysts. I aimed to characterise AcMBP as a basis for developing future drugs against Acanthamoeba. To start with, I carried out morp

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39

McMullen, Jr Richard Joseph. "Equine keratitis and the possible involvement of equine adenovirus type 1 (EAdV1) and type 2 (EAdV2)." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-34239.

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40

Moser, Melanie A. "A Descriptive Review of Balamuthia and Non-Keratitis Acanthamoeba Cases in the United States, 1955-2009." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/iph_theses/162.

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Free-living amebae are ubiquitous in the environment and occasionally invade and parasitize host tissues causing illness in humans. Despite possibly frequent exposure to these organisms, infection is rare and why some people, healthy or not, end up with illness and others do not is still unclear. Human infections are rare; when illness does occur, it is often fatal. Only two papers have examined data from the literature and cases reported to the Centers for Disease Control and Prevention, and both were published over twenty years ago. The purpose of this study is to better document the epi

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41

de, Jesus-Carrion Steven. "Fungal Keratitis: Immune Evasion, Host-Pathogen Interactions, and Virulence Factors during Aspergillus Fumigatus Infection." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1417783811.

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42

Machens, Matthias. "The outcome of corneal grafting and patients with stromal keratitis of herpetic and non-herpetic origin /." Bern : [s.n.], 2003. http://www.stub.unibe.ch/html/haupt/datenbanken/diss/bestell.html.

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43

Katragadda, Suresh Mitra Ashim K. "Design of amino acid prodrugs of acyclovir for improved bioavailability and therapeutic activity utility in treating ocular, oral and genital herpes infections /." Diss., UMK access, 2007.

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Thesis (Ph. D.)--School of Pharmacy and Dept. of Chemistry. University of Missouri--Kansas City, 2007.<br>"A dissertation in pharmaceutical sciences and chemistry." Advisor: Ashim K. Mitra. Typescript. Vita. Description based on contents viewed July 16, 2008; title from "catalog record" of the print edition. Includes bibliographical references (leaves 173-182). Online version of the print edition.

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44

Perches, Cintia Sesso [UNESP]. "Uso de colírios à base de Citrus lemon no reparo de úlcera de córnea induzida em coelhos: avaliação clínica, histomorfométrica e imuno-histoquímca." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/99364.

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45

Trevisan, Brandi C. "Encystment of Acanthamoeba and Evaluating the Biobus Program." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_diss/88.

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Acanthamoeba are ubiquitous protists that play an environmental role in regulating microbial diversity; they also occasionally cause infections of the eye (Acanthamoeba keratitis) and brain (granulomatous amoebic encephalitis). These organisms exhibit two distinct phenotypes. The trophozoite form dominates in favorable conditions, in which the Acanthamoeba move through the extension of pseudopodia, engulfing microbes and other particles. During stressful conditions, the Acanthamoeba undergo a process of encystment, in which they build a double cell wall and become relatively inactive. The

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46

Williams, Susan R. "Role of Mal/TIRAP in TLR2- and TLR4-, but not TLR5-Induced Corneal Inflammation." Cleveland, Ohio : Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1259983828.

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47

Chinnery, Holly Rose. "Dendritic cells and macrophages in the mammalian cornea : distribution, morphology, phenotype and their role in responding to microbial challenge." University of Western Australia. School of Anatomy and Human Biology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0217.

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[Truncated abstract] The cornea plays a major role in the refraction of light and thus the maintenance of its transparency is critical for optimal vision. Infection or trauma can initiate a host inflammatory response, which can cause edema of the collagenous stroma. This tissue edema compromises vision by disrupting the regular arrangement of the corneal stromal lamellae, whose organization is critical to its refractive properties. Until recently, it was the accepted dogma that the cornea was an immune privileged tissue owing in part to its avascular nature and paucity of resident macrophages

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48

Danboise, Brook Alicia. "Role of MAP Kinase in Fusarium Association With Contact Lenses." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/biology_diss/45.

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Fusarium solani is a soil-borne pathogen devastating agricultural crops throughout the world. While most pathogens are host specific, the fusaria are able to infect both plants and animals. In 2004, an outbreak of Fusarium occurred in association with contact lens wear. Several species of Fusarium were involved but F. solani and F. oxysporum were most prominent. In this work, we have identified a MAP kinase (MAPK), highly similar to fmk1 in F. oxysporum, belonging to the YERK1 subfamily of extracellular regulated kinases. Directed disruption of fmk1 in F. solani AFR4 (FSSC 1) affected several

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Lu, Liang. "CLINICAL AND ANIMAL STUDIES OF LIPID-DERIVED PROTEIN MODIFICATIONS IN AUTISM, KIDNEY DIALYSIS, KERATITIS AND AGE-RELATED MACULAR DEGENERATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1180231149.

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Perches, Cintia Sesso. "Uso de colírios à base de Citrus lemon no reparo de úlcera de córnea induzida em coelhos : avaliação clínica, histomorfométrica e imuno-histoquímca /." Botucatu : [s.n.], 2011. http://hdl.handle.net/11449/99364.

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Orientador: Cláudia Valéria Seullner Brandão<br>Banca: José Joaquim Titton Ranzani<br>Banca: Alexandre Lima de Andrade<br>Resumo: O objetivo do presente estudo foi avaliar e comparar por meio de exames oftalmológicos, histopatológicos e imuno-histoquímica para PCNA, o processo de reparação corneal de úlceras superficiais induzidas em coelhos, frente à utilização de colírios de óleo essencial de Citrus lemon, produto até então não utilizado em oftalmologia. Foram utilizadas 50 fêmeas da espécie leporina, todas submetidas à indução da úlcera superficial, constituindo-se 5 grupos experimentais de

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