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Rozprawy doktorskie na temat „Kidney glomerulus Diseases”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 21 lutego 2023

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1

Wang, Yang. "Murine adriamycin-induced nephropathy : the roles of cell-mediated immunity and CD4+ T-lymphocytes." Thesis, The University of Sydney, 2000. https://hdl.handle.net/2123/27827.

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Leung, Chi-kam Joseph, and 梁志錦. "The pathogenesis of IgA nephropathy: the roleof IgA molecule and the nature of IgA receptors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29744908.

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Wootton, Andrew. "The glomerular basement membrane and nephritis /." Title page, contents and abstract only, 1985. http://web4.library.adelaide.edu.au/theses/09PH/09phw918.pdf.

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Cavaglieri, Rita de Cássia. "Terapia com células tronco derivadas do líquido amniótico humano na nefropatia crônica experimental: é possível bloquear a progresso da doença renal estabelecida?" Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-09052018-101720/.

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Células tronco mesenquimais (CTm) apresentam potencial para tratamento da doença renal pela possibilidade de promover regeneração tecidual e recuperação funcional, possivelmente por seus efeitos parácrinos. Na última década, o líquido amniótico foi descrito como uma fonte promissora de extração e isolamento de CTm. Alguns estudos mostraram o efeito renoprotetor das CTm derivadas do líquido amniótico (CTmLA) na doença renal aguda e crônica, quando inoculadas precocemente. Entretanto, ainda não foi estudado o efeito da administração de CTmLA em modelo experimental de doença renal crônica (DRC) c

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5

Brittain, Alison Louise. "Growth Hormone (GH) and the Glomerular Podocyte." Ohio University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1554208861914841.

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Sousa, Mauri Félix de. ""Efeitos renais da haploinsuficiência do gene Pkd1 (Polycystic kidney disease 1) em camundongos"." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-21122005-163447/.

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Vários estudos mostram que na doença renal policística autossômica dominante os cistos surgem a partir de um mecanismo de "dois-golpes". A patogênese das manifestações não-císticas, contudo, é pouco compreendida. Neste estudo usamos uma linhagem de camundongos endogâmica com uma mutação nula em Pkd1, onde animais heterozigotos apresentam formação cística renal mínima até 40 semanas de idade. O clearance de inulina e o número de glomérulos foram menores em machos Pkd1+/- que Pkd1+/+, enquanto o volume glomerular médio foi maior em heterozigotos. A excreção urinária de NO2/NO3 não diferiu signif

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7

Baboolal, Keshwar. "The renin angiotensin system in experimental renal disease." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336469.

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8

Randles, Michael. "Proteomic analyses of kidney glomerular extracellular matrix in health and disease." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/proteomic-analyses-of-kidney-glomerular-extracellular-matrix-in-health-and-disease(a39fe408-db06-4d80-b97b-4e0651bf7bc3).html.

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Glomerular filtration is a vital physiological process removing waste products from the circulation and this process occurs across the glomerular filtration barrier (GFB). The cells and extracellular matrix (ECM), which form this barrier, are exposed to forces during ultrafiltration and special adaptation is required to withstand these forces. Dysfunction in cellular adhesion machinery or ECM assembly within the GFB causes loss of selective glomerular filtration, however, the mechanisms governing these processes are poorly understood. To this end we sought to characterise the glomerular ECM an

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9

Sheerin, Neil Stephen. "Complement in the pathogenesis of immune mediated glomerular injury." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313287.

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10

Stitt, Erin Maureen. "The Role of Podocyte Prostaglandin E2 and Angiotensin II Receptors in Glomerular Disease." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19800.

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The incidence of chronic kidney disease (CKD) is increasing. CKD is characterized by a gradual decrease in renal function leading to end stage renal disease (ESRD). Damage to the glomerular podocytes, is one of the first hallmarks of CKD. We hypothesized that podocyte prostaglandin E2 (PGE2) receptors contribute to the progression of glomerular injury in models of CKD. To test this hypothesis, transgenic mice were generated with either podocyte-specific overexpression or deletion of the PGE2 EP4 receptor (EP4pod+and EP4pod-/- respectively). Mice were next tested in the 5/6 nephrectomy (5/6 Nx)

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11

Dhaun, Neeraj. "Endothelin system & its antagonism in chronic kidney disease." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6528.

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Since its discovery in 1988 the powerful vasoconstrictor endothelin-1 (ET-1) has been widely implicated in the pathophysiology of chronic kidney disease (CKD) as well as the cardiovascular disease with which it is associated. ET receptor antagonists have favourable effects in experimental models of these conditions and orally acting antagonists are now licensed for the treatment of pulmonary arterial hypertension. However, there is a paucity of human data regarding the role of ET-1 in CKD. In this thesis, I have therefore explored the utility of ET-1 as a biomarker in CKD, and, using selective

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12

Parry, Robin Geoffrey. "Cytokines in minimal change nephropathy." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341511.

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13

Kampa, Naruepon. "Renal scintigraphy in dogs : evaluation of glomerular filtration rate measurement by 99mTc-DTPA renogram /." Uppsala : Dept. of Biomedical Sciences and Public Health, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200609.pdf.

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14

Boisvert, Naomi. "The Role of Ubiquitin C-Terminal Hydrolase L1 in Renal Function and Glomerular Disease." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36927.

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Ubiquitin C-terminal hydrolase L1 is a deubiquitinating enzyme that salvages ubiquitin from substrates and maintains intracellular ubiquitin pools. While the role of ubiquitin C-terminal hydrolase L1 is well characterized in neurons, there is an increasing scope of evidence to suggest that ubiquitin C-terminal hydrolase L1 also plays a role in renal function and glomerular disease, however, its specific role in these settings remains incompletely elucidated. In the present thesis we explored the role of ubiquitin C-terminal hydrolase L1 in a mouse model of glomerular disease, ACTN4-associated

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15

Xiao, Xue. "C3 glomerulopathy: exploring the role of the glomerular micro-environment in disease pathogenesis." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/6019.

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C3 glomerulopathy (C3G) encompasses a group of severe renal diseases characterized by “dominant C3” deposition in the renal glomerulus. Patients typically present as nephritic nephrotics, with hematuria, hypertension, heavy proteinuria and edema. Within ten years of diagnosis, 50% of affected patients progress to end-stage renal disease and require dialysis or renal transplantation. No treatment is available to halt disease progression and thus both disease recurrence and allograft loss are common after transplantation. Genetic studies of C3G have firmly implicated dysregulation of the alterna

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16

Duan, Erning. "The Effects of Heparin-binding EGF-like Growth Factor on The Development of Diabetic Renal Disease." Miami University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=miami1258581611.

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17

Kaiser, Tiffany E. "An Appropriate Assessment of Kidney Function In Patients with End Stage Liver Disease: Role of Cystatin C." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396532967.

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18

He, Jiang, Michael Shlipak, Amanda Anderson, Jason A. Roy, Harold I. Feldman, Radhakrishna Reddy Kallem, Radhika Kanthety, et al. "Risk Factors for Heart Failure in Patients With Chronic Kidney Disease: The CRIC (Chronic Renal Insufficiency Cohort) Study." WILEY, 2017. http://hdl.handle.net/10150/625054.

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Background-Heart failure is common in patients with chronic kidney disease. We studied risk factors for incident heart failure among 3557 participants in the CRIC (Chronic Renal Insufficiency Cohort) Study. Methods and Results-Kidney function was assessed by estimated glomerular filtration rate (eGFR) using serum creatinine, cystatin C, or both, and 24-hour urine albumin excretion. During an average of 6.3 years of follow-up, 452 participants developed incident heart failure. After adjustment for age, sex, race, and clinical site, hazard ratio (95% CI) for heart failure associated with 1 SD lo

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19

Hassouneh, Ramzi. "Prostaglandin E2 Receptor 3 (EP3) Contributes to Polyuria, Glomerular Hyperfiltration, and Renal Injury in Diabetes." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32773.

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Cyclooxygenases (COXs) and their main renal product, prostaglandin E2 (PGE2), regulate many physiological renal functions and are involved in the pathogenesis of diabetic kidney disease. The PGE2 receptor EP3 has been repeatedly shown to be upregulated during diabetes. Physiologically, EP3 is best recognized to act as a diuretic by antagonizing arginine-vasopressin (AVP)-mediated water reabsorption. Incidentally, the first renal manifestation of diabetes is polyuria, which may trigger a cascade of events leading to DN. We hypothesize that EP3 contributes to polyuria and kidney dysfunction duri

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20

Dehmer, Susanne. "Validation of Abbott Diagnostics turbidimetric cystatin C assay and enzymatic creatinine assay using the Architect c8000 analyzer." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105609.

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<p><strong>Objective</strong><em>:</em> Estimation of glomerular filtration rate (GFR) is an important tool in the diagnosis and management of chronic kidney disease. Today creatinine is the most frequently used marker for kidney function though several studies indicate that cystatin C is a superior marker. The purpose of this study was to validate Abbott Diagnostics turbidimetric cystatin C assay and enzymatic creatinine assay.</p><p><strong>Methods</strong><em>:</em> The validation was performed by studies of CV for the two methods and correlations between the two and other available methods

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21

Tynkevich, Elena. "Muscle Wasting in Non-end Stage Chronic Kidney Disease : Determinants and Outcomes." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T086.

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Faible masse musculaire a été peu étudiée chez les patients avant le stade terminal de la maladie rénale chronique (MRC). Nous avons évalué la masse musculaire à partir de la créatininurie des 24h pour étudier ses déterminants, son évolution avec le déclin de la fonction rénale ainsi que ses liens avec les risques de progression vers l’insuffisance rénale terminale traitée (IRTT) et de décès avant IRTT. Dans la cohorte NephroTest incluant 1429 patients avec une MRC stades 1 à 4, le débit de filtration glomérulaire a été mesuré par la clairance du 51Cr-EDTA (DFGm) et estimé par l’équation CKD E

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22

Antunes, Susyane Almeida de Souza. "Efeito do tratamento periodontal em pacientes com doença renal crônica." Universidade do Estado do Rio de Janeiro, 2007. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6348.

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Fundação de Amparo a Pesquisa do Estado da Bahia<br>O objetivo deste trabalho foi avaliar o efeito do tratamento periodontal sobre marcadores (PCR, albumina, colesterol e triglicerídeos) em indivíduos com Doença Renal Crônica (CRD) bem como sobre o curso da progressão dessa doença. Vinte e seis pacientes, idade média de 60 ( 11,2) anos, com Doença Renal Crônica estágios 3 e 4 com periodontite crônica não severa e severa receberam terapia básica periodontal. Parâmetros clínicos periodontais incluíram Índice de Placa (IP), Sangramento à Sondagem (SS), Profundidade de Bolsa à Sondagem (PBS), Níve

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23

Antunes, Susyane Almeida de Souza. "Efeito do tratamento periodontal no aumento da taxa de filtração glomerular em pacientes renais crônicos." Universidade do Estado do Rio de Janeiro, 2011. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6718.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>O objetivo foi avaliar o efeito do tratamento periodontal sobre a progressão da disfunção renal e marcadores sorológicos metabólicos (albumina, colesterol e triglicerídeos) em indivíduos com Doença Renal Crônica (DRC) e periodontite crônica. Cinquenta e sete pacientes com DRC na pré-diálise com periodontite crônica foram avaliados 90 dias e 29 pacientes foram avaliados 180 dias após a terapia básica periodontal. Parâmetros clínicos periodontais incluíram índice de placa (IP), sangramento a sondagem (SS), profundidade de Bolsa à Son

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24

Nerpin, Elisabet. "The Kidney in Different Stages of the Cardiovascular Continuum." Doctoral thesis, Högskolan Dalarna, Medicinsk vetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-209644.

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Patients with chronic kidney disease are at higher risk of developing cardiovascular disease. The complex, interaction between the kidney and the cardiovascular system is incompletely understood, particularly at the early stages of the cardiovascular continuum. The overall aim of this thesis was to clarify novel aspects of the interplay between the kidney and the cardiovascular system at different stages of the cardiovascular continuum; from risk factors such as insulin resistance, inflammation and oxidative stress, via sub-clinical cardiovascular damage such as endothelial dysfunction and lef

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25

Paníco, Marilia Duarte Brandão. "Doença da artéria periférica sintomática e assintomática:fatores de risco e associação à filtração glomerular." Universidade do Estado do Rio de Janeiro, 2010. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1755.

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A Doença da Artéria Periférica (DAP) é o resultado do processo aterosclerótico das artérias dos membros superiores, inferiores, aorta abdominal e seus ramos viscerais. Nosso objetivo foi detectar a DAP correlacionando-a com fatores de risco (FR) e a filtração glomerular estimada (FGe) nos pacientes com ≥30 anos, assistidos na Unidade docente - assistencial de Angiologia (UDA) do Hospital Universitário Pedro Ernesto da Faculdade de Ciências Médicas - UERJ, com o intuito de descrever os FR e associação com doença renal crônica à DAP, a partir da aferição do índice tornozelo-braço (ITB); de

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Nagy, I. I. (Irina I. ). "Wnt-11 signaling roles during heart and kidney development." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526204666.

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Abstract Organogenesis involves precursor cells proliferation, differentiation along with their coordinated organization into precise multicellular arrangements by planar cell polarity (PCP) pathways. The beta-catenin independent/non-canonical type of Wnt-11 signaling has been known as a PCP modulator during development. In this thesis were analyzed the roles of Wnt-11 in heart and kidney development by using in vivo functional genomics technologies. We show that the Wnt-11 gene is important for murine ventricular myocardium development, since Wnt-11 deficiency in early cardiogenesis leads to

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27

Contreras, Macazana Roxana Milagros. "Estimación de la tasa de filtración glomerular usando las ecuaciones CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) y MDRD 4 (Modification of Diet in Renal Disease) en pacientes diabéticos tipo 2 atendidos en HNERM." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2014. https://hdl.handle.net/20.500.12672/8961.

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Publicación a texto completo no autorizada por el autor<br>Determina la correlación y el grado de concordancia entre la ecuación de CKD-EPI y MDRD con la depuración de creatinina en orina de 24 horas para la estimación de la tasa de filtrado glomerular en pacientes diabéticos tipo 2, mayores de edad que acuden al servicio de Patología Clínica sección Bioquímica depuración de creatinina del HNERM, en el periodo octubre a diciembre 2013. Es un estudio Analítico comparativo, prospectivo observacional. Se obtuvo una muestra de 152 pacientes diabéticos, se aplicó el test de correlación de spearma

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Johnston, Nicklett Johnston. "The Effect of Health Literacy in Low Estimated Glomerular Filtration and Diabetes." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3895.

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Health literacy is widespread, but its potential is not recognized. By not recognizing health literacy, patients have the burden of coping with diabetes with renal complications without full knowledge of their responsibility to their health. The focus of the project was to assess participants with diabetes with low health literacy and low mean glomerular filtration rate (eGFR). The project goal was achieved by the assessment of the participants' health literacy and eGFR before and after education for their diabetes, then assessed to determine if teaching the participants would improve their he

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Magacho, Edson José de Carvalho. "Rastreamento da doença renal crônica: validação do questionário “Scored" nomograma para estimativa da taxa de filtração glomerular e avaliação dos marcadores funcional e de lesão do parênquima renal." Universidade Federal de Juiz de Fora (UFJF), 2014. https://repositorio.ufjf.br/jspui/handle/ufjf/5552.

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Submitted by isabela.moljf@hotmail.com (isabela.moljf@hotmail.com) on 2017-08-11T13:00:25Z No. of bitstreams: 1 edsonjosedecarvalhomagacho.pdf: 1270417 bytes, checksum: 31d136c0dff33a402802624129e69c27 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-08-11T13:02:58Z (GMT) No. of bitstreams: 1 edsonjosedecarvalhomagacho.pdf: 1270417 bytes, checksum: 31d136c0dff33a402802624129e69c27 (MD5)<br>Made available in DSpace on 2017-08-11T13:02:58Z (GMT). No. of bitstreams: 1 edsonjosedecarvalhomagacho.pdf: 1270417 bytes, checksum: 31d136c0dff33a4028

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Tollendal, Ana Luisa Silveira Vieira. "Avaliação dos níveis séricos de ácido úrico como fator de risco para o declínio da taxa de filtração glomerular em pacientes com doença renal crônica." Universidade Federal de Juiz de Fora (UFJF), 2018. https://repositorio.ufjf.br/jspui/handle/ufjf/6722.

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Submitted by Geandra Rodrigues (geandrar@gmail.com) on 2018-04-27T11:55:53Z No. of bitstreams: 1 analuisasilveiravieiratollendal.pdf: 1031624 bytes, checksum: 2a4a0647b9d22be1da3f719765d6d470 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2018-04-27T12:09:21Z (GMT) No. of bitstreams: 1 analuisasilveiravieiratollendal.pdf: 1031624 bytes, checksum: 2a4a0647b9d22be1da3f719765d6d470 (MD5)<br>Made available in DSpace on 2018-04-27T12:09:21Z (GMT). No. of bitstreams: 1 analuisasilveiravieiratollendal.pdf: 1031624 bytes, checksum: 2a4a0647b9d22be1da3f71

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Pinho, Natália Alencar de. "Fatores associados à doença renal crônica em pacientes internados em um hospital universitário na cidade de São Paulo." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/7/7139/tde-19092013-154219/.

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Introdução: a doença renal crônica constitui importante problema de saúde pública mundial. Contudo, pouco se sabe sobre suas características em nosso meio. Objetivo: identificar os fatores associados à doença renal crônica em pacientes internados em um hospital universitário. Método: foram selecionados, aleatoriamente, 386 pacientes que constituíram dois grupos: com e sem doença renal crônica. A doença renal crônica foi definida pela presença de diagnóstico médico ou antecedente pessoal. Os dados foram obtidos do prontuário do paciente. Foram comparados os grupos com e sem doença renal crônica

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Singh, Dhruvaraj Kailashnath. "Clinical studies in diabetic vasculopathy to assess interactions between blood, bone and kidney." Thesis, University of Hertfordshire, 2010. http://hdl.handle.net/2299/4186.

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Diabetic vasculopathy (DV) is the most important consequence of chronic hyperglycemia in patients with diabetes mellitus (DM). This thesis explores the interaction of blood, bone and kidney in the pathogenesis of DV by i) reviewing the current understanding of pathogenesis of macrovascular and microvascular diseases in DM to identify gaps in literature and generate hypotheses relating to various facets of DV ii) undertaking a series of prospective studies to examine these hypotheses iii) analysing the findings and integrating any new information obtained from the clinical studies into the curr

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Cheddani, Lynda. "Comparaison du risque cardiovasculaire et de la mortalité entre patients transplantés rénaux et malades rénaux chroniques à fonction rénale équivalente. Uremic Toxins and Clinical Outcomes: The Impact of Kidney Transplantation Higher mortality risk among kidney transplant recipients than among estimated glomerular filtration rate-matched patients with CKD – preliminary results Less arterial stiffness in kidney transplant recipients than chronic kidney disease patients matched for renal function." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASR006.

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La maladie rénale chronique(MRC) s’associe à un très haut risque cardiovasculaire(CV), et les maladies CV représentent après greffe une des principales causes de décès avec greffon fonctionnel. Le débit de filtration glomérulaire(DFG) influe sur le risque CV. L’objectif de ce travail était de comparer pour la 1ère fois patients MRC et transplantés rénaux(TR) à même niveau de DFG sur 1) le risque de mortalité; 2) le niveau de rigidité aortique (évaluée par la vitesse de l’onde de pouls carotido-fémorale, CF-VOP). Le 3ème objectif visait à comparer l’évolution de la pression pulsée (PP) selon le

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34

Magalhães, Andréa Olivares. "Papel do fósforo e do paratormônio na progressão da doença renal crônica." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-04042008-142314/.

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Introdução: Os mecanismos envolvidos na progressão da doença renal crônica (DRC) independentemente de sua etiologia, não estão totalmente esclarecidos. O controle do fósforo(P) sérico é uma meta essencial a ser alcançada no tratamento de pacientes com DRC. Inicialmente, a importância deste controle era atribuída a participação do P na patogênese do hiperparatireoidismo secundário. Atualmente sabe-se que a hiperfosfatemia aumenta a mortalidade desses pacientes. Distúrbios do metabolismo mineral participam da progressão da DRC, porém os mecanismos envolvidos na fisiopatologia, não foram esclarec

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Kaboré, Jean. "Hypertension artérielle résistante et maladie rénale chronique : déterminants et risques associés." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS265/document.

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Hypertension artérielle résistante et maladie rénale chronique : Déterminants et risques associésL’hypertension résistante, définie par une pression artérielle au-dessus de la cible en dépit de la prise de trois antihypertenseurs à dose optimale dont un diurétique, est fréquemment associée à la maladie rénale chronique (MRC). Sa prévalence, ses déterminants et l’impact potentiel de la MRC sur son pronostic à long terme sont mal connus, notamment chez le sujet âgé. Dans l’étude des 3 cités, incluant 4262 personnes de plus de 65 ans traitées pour hypertension, la prévalence de l’hypertension app

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Boubred, Farid. "Conséquences vasculaires et rénales à long terme de la restriction de croissance intra-utérine et de la nutrition postnatale chez le rat." Thesis, Aix-Marseille 2, 2010. http://www.theses.fr/2010AIX20693.

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Le faible poids de naissance et/ou une accélération de la croissance pondérale durant l’enfance sont reconnus actuellement comme facteur de risque de maladies cardiovasculaires (hypertension artérielle, en particulier). Leur rôle dans la progression des maladies rénales chroniques de l’adulte est moins évident. Cette association entre un faible poids de naissance et un risque accru d’hypertension artérielle (HTA) à l’âge adulte ferait intervenir une réduction du nombre de néphrons. Ce déficit néphronique, associé au faible poids de naissance, est responsable d’une hyperfiltration glomérulaire

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Boucquemont, Julie. "Modèles statistiques pour l'étude de la progression de la maladie rénale chronique." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0411/document.

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Cette thèse avait pour but d'illustrer l'intérêt de méthodes statistiques avancées lorsqu'on s'in téresse aux associations entre différents facteurs et la progression de la maladie rénale chronique (MRC). Dans un premier temps, une revue de la littérature a été effectuée alin d'identifier les méthodes classiquement utilisées pour étudier les facteurs de progression de la MRC ; leurs limites et des méthodes permettant de mieux prendre en compte ces limites ont été discutées. Notre second travail s'est concentré sur les analyses de données de survie et la prise en compte de la censure par inter

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Canale, Daniele. "Mecanismos de lesão renal em ratos com deficiência de vitamina D submetidos ao tratamento com Tenofovir." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-06062014-100748/.

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A Síndrome da Imunodeficiência Adquirida (AIDS) é um problema de saúde pública. O Tenofovir Disoproxil Fumarato (TDF) foi o primeiro inibidor do nucleotídeo da transcriptase reversa e é a droga mais recomendada para o tratamento da AIDS. Entretanto, o uso prolongado de TDF está associado com a nefrotoxicidade. A deficiência de vitamina D tem alta prevalência em indivíduos infectados com o Vírus da Imunodeficiência Humana (HIV). A vitamina D participa da regulação de atividades fisiológicas de diversos órgãos, incluindo o rim, oferecendo proteção contra as lesões ocasionadas por diferentes caus

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"The association of various HLA-A, -B and -DR loci with membranous glomerulonephritis, IgA nephropathy, and focal segmental glomerulosclerosis in KwaZulu-Natal renal patients." Thesis, 2007. http://hdl.handle.net/10413/1789.

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This KwaZulu-Natal (KZN) based study investigates hypertension, glomerulonephritides and the rarity of IgA Nephropathy (IgAN) in Africans in association with the Human Leukocyte Antigen (HLA). A retrospective hypertensive study found a positive association with HLA-B40 (P c<0.05) and HLA-B15 (Pc<0.02) in Indians and Africans respectively. No association was found in Whites. A prospective study showed glomerulonephritides to be positively associated with HLA-A33 in Indians (Pc 0.049). No associations were found with glomerulonephritides in Africans and Whites. Combined Race groups show no HLA a

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Wootton, Andrew. "The glomerular basement membrane and nephritis." 1986. http://web4.library.adelaide.edu.au/theses/09PH/09phw918.pdf.

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Sivaskandarajah, Gavasker. "Role of Vascular Endothelial Growth Factor-A in Diabetic Kidney Disease." Thesis, 2011. http://hdl.handle.net/1807/29625.

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Vascular endothelial growth factor-A (VEGF) is required for endothelial cell differentiation and survival. To investigate the renoprotective properties of VEGF in diabetes an inducible Cre-loxP gene targeting system was used to excise VEGF from podocytes of adult mice (VEGFKO). Diabetes was induced by streptozotocin (STZ) at 2.5 weeks of age and VEGFKO was induced by doxycycline (dox) at 3-4 weeks of age. Blood and urine were collected weekly to monitor for hyperglycaemia and proteinuria, respectively. Mice were dissected 8 weeks after diabetes induction or earlier if morbidly ill; twenty pe

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Belghasem, Mostafa. "Pathological and molecular profiling in hypertension-induced glomerular injury." Thesis, 2015. https://hdl.handle.net/2144/13940.

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The increased prevalence of chronic kidney disease (CKD) has become a major global health burden. This increase in CKD burden parallels the increase in hypertension prevalence. In addition, increasing evidence suggest that genetics play a strong role in the susceptibility for renal disease. Inbred mouse strains C57BL/6 and 129S6SvEv differ in their susceptibility to kidney disease when subjected to hypertension using the DOCA/salt uninephrectomy model of hypertension. Similar to others, we found the 129S6SvEv mice to be susceptible to develop severe glomerulosclerosis, whereas the C57BL/6 mice

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Bondzie, Philip Apraku. "New insights into the molecular regulation of kidney disease: contributions of APOL1 and MYH9." Thesis, 2014. https://hdl.handle.net/2144/15338.

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People of African ancestry (AA) are at greater risk of developing chronic kidney disease than those of non-AA. Much of this risk has been linked to specific genetic haplotypes on chromosome 22, near the genes APOL1, encoding apolipoprotein L1, and MYH9, encoding non-muscle myosin heavy chain IIA (NMHCIIA). The mechanisms by which the disease-associated chromosome 22 haplotypes promote kidney damage are unknown. Apolipoprotein L1 is a circulating protein with no known role in kidney function. However, the kidney disease-associated chromosome 22 haplotypes are protective against trypanosome infe

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Naudin, Crystal. "The tetraspanin CD151’s role in the kidney and mapping of genetic modifiers of glomerular disease." Thesis, 2015. http://hdl.handle.net/1959.13/1305765.

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Research Doctorate - Doctor of Philosophy (PhD)<br>Glomerular diseases represent a major burden for both patients and the community. They are responsible for a significant proportion of chronic kidney disease, which can ultimately progress to end stage renal disease, requiring dialysis or transplantation. Glomerular diseases are associated with leakage of proteins across the glomerular filtration barrier into the primary urine (proteinuria or albuminuria – as albumin is the major protein involved). The glomerular filtration barrier is composed of three interconnected layers: podocyte foot proc

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Hsu, Chung-Pang, and 許仲邦. "To evaluate the prediction of cardiovascular diseases hospitalizations, incident dialysis, and mortality by different estimated glomerular filtration rate equations in patients with chronic kidney diseases." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/94028671939221198480.

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碩士<br>高雄醫學大學<br>醫學研究所<br>100<br>Background: Chronic kidney disease (CKD) has been considered as a global public health problem in the world. The definition of CKD is based on criteria of proteinuria and level of glomerular filtration rate (GFR). Simplified MDRD equation for estimating GFR is most commonly used in clinics. It is not guaranteed that applying the equation to Taiwanese would not result in bias for GFR. Therefore, Taiwanese MDRD equation and Taiwan-intercept equation had been proved more accurate estimation for GFR. However, the performance of predicting risk through estimated GFR

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Graça, Ana Beatriz Nunes. "Proteinúria na doença renal crónica: fisiopatologia e valor prognóstico." Master's thesis, 2020. http://hdl.handle.net/10316/97872.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>A doença renal crónica (DRC) é muito prevalente na população geral e classifica-se de acordo com a sua causa, taxa de filtração glomerular e severidade da proteinúria. O papel da proteinúria no desenvolvimento e progressão da DRC tem sido amplamente estudado e têm-se observado alterações das guidelines internacionais relativas à sua classificação, diagnóstico e tratamento. Vários autores propõem que a proteinúria apresenta mecanismos fisiopatológicos que não só influenciam a progressão da DRC como também tê

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Lourenço, Rute Sofia Sargaço. "Relatório de Estágio e Monografia intitulada “A influência das fórmulas da TFG no ajuste de dose em doentes com insuficiência renal"." Master's thesis, 2020. http://hdl.handle.net/10316/93016.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>This work is the culmination of the internship report and monograph.I had the opportunity to do two curricular internships, one in Community Pharmacy and the other in Pharmaceutical Industry, which proved to be an asset for my professional training.In the internship reports, a retrospective evaluation is performed, through a SWOT analysis (Strengths; Weaknesses;Opportunities; Theats). This analysis made it possible to identify the internal factors that contributed to my learning, namely,

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Snaith, Beverly, Martine A. Harris, B. Shinkins, M. Jordaan, M. Messenger, and A. Lewington. "Point-of-care creatinine testing for kidney function measurement prior to contrast-enhanced diagnostic imaging: evaluation of the performance of three systems for clinical utility." 2018. http://hdl.handle.net/10454/15685.

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Yes<br>Acute kidney injury (AKI) can occur rarely in patients exposed to iodinated contrast and result in contrast-induced AKI (CI-AKI). A key risk factor is the presence of pre-existing chronic kidney disease (CKD), therefore it is important to assess patient risk and obtain kidney function measurement prior to administration. Point of care (PoC) testing provides an alternative strategy but there remains uncertainty, with respect to diagnostic accuracy and clinical utility. A device study compared three PoC analysers (Nova StatSensor, Abbott i-STAT, Radiometer ABL800 FLEX) with a reference l

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Spieker, Christine. "Die Bedeutung der glomerulären Basalmembrankomponente Nidogen-1 bei podozytären Erkrankungen der Niere." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3E54-4.

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