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Rozprawy doktorskie na temat „Kidney inflammation”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Khalaf, Fatimah. "Regulation of Renal Inflammation in Chronic Kidney Disease." University of Toledo Health Science Campus / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=mco1588943852414778.

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Campos-Pereira-Da-Cruz-Viana, Joao. "Exercise in chronic kidney disease : impact on immunity and inflammation." Thesis, Loughborough University, 2011. https://dspace.lboro.ac.uk/2134/9090.

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Chronic kidney disease (CKD) is associated with a complex state of immune dysfunction characterised by immune depression, which predisposes CKD patients to infections, and by immune activation resulting in inflammation, which is associated with cardiovascular disease among these patients. It has been suggested that regular moderate exercise may enhance immune function and exert anti-inflammatory effects. However, such effects are still unclear in CKD. Therefore, we investigated the effects of acute and regular (1-month and 6-months) moderate intensity aerobic exercise (walking) on measures of

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YANG, JI YEON. "CD40 monocyte differentiation mediates tissue inflammation in chronic kidney disease." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/349139.

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Pharmacology<br>Ph.D.<br>Patients with chronic kidney disease (CKD) develop hyperhomocysteinemia (HHcy), have increased inflammatory monocytes (MC) and 10-times higher cardiovascular mortality than the general population. Here, we investigated HHcy-related MC differentiation in CKD. Twenty seven CKD and CVD, and 14 healthy subjects were recruited. CD40 was selected as a CKD-induced MC activation marker by mining for CKD-MC-mRNA screen database. We found that CD14++CD16+ MC, often denoted as inflammatory subset, soluble CD40 ligand (sCD40L), and TNFα/IL-6 levels were augmented in CVD and CKD su

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Dupre, Tess V., Mark A. Doll, Parag P. Shah, et al. "Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury." AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2017. http://hdl.handle.net/10150/624924.

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Acute kidney injury (AKI), resulting from chemotherapeutic agents such as cisplatin, remains an obstacle in the treatment of cancer. Cisplatin-induced AKI involves apoptotic and necrotic cell death, pathways regulated by sphingolipids such as ceramide and glucosylceramide. Results from this study indicate that C57BL/6J mice treated with cisplatin had increased ceramide and hexosylceramide levels in the renal cortex 72 h following cisplatin treatment. Pretreatment of mice with inhibitors of acid sphingomyelinase and de novo ceramide synthesis (amitriptyline and myriocin, respectively) prevented

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5

Chitalia, Nihil A. "Vitamin D, inflammation and cardiovascular disease in patients with chronic kidney disease." Thesis, St George's, University of London, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616978.

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Cardiovascular (CV) disease is the commonest cause of mortality in CKD. CV mortality is not entirely explained by traditional CV risk factors and therefore systemic inflammation and vitamin D deficiency are thought to play a major role in CKD. Vitamin D [25 (hydroxy vitamin D; 25(OH)D] modulates adaptive immune responses and 25(OH)D deficiency is associated with CV mortality. Vascular endothelial dysfunction is a surrogate marker of atherosclerotic CV disease and related to systemic inflammation in CKD. However, the role of vitamin D on inflammation and endothelial function in CKD is largely u

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6

Bogart, Avery M. "STAT5 Knockout Mice Show Increased Susceptibility to Cisplatin-Induced Acute Kidney Injury." Ohio University Honors Tutorial College / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1524841830342307.

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Nehus, Edward J. "Correlates of Resistin in Children with Chronic Kidney Disease: The CKiD Cohort." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1318862589.

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8

Cheung, Katharine Lana. "Chronic Kidney Disease and the Risk of Venous Thromboembolism." ScholarWorks @ UVM, 2018. https://scholarworks.uvm.edu/graddis/879.

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Chronic kidney disease (CKD) affects more than 30 million adults in the U.S. and is strongly associated with cardiovascular events and mortality. Venous thromboembolism (VTE) is the third leading vascular disease, affects up to 900,000 Americans each year and contributes to as many as 100,000 deaths annually. The relationship of CKD and VTE has been described in patients receiving dialysis, kidney transplants recipients and in nephrotic syndrome, however, data supporting the association of VTE in mild to moderate CKD is conflicted. The overall goal of this research was to study the association

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9

Palau, González Vanesa. "Role of ADAM17 in kidney disease: a clinical and experimental approach”." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/672003.

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Les desintegrines i metal·loproteases (ADAMs) són una família de proteïnases que alliberen dominis proteics solubles en un procés conegut com a “shedding”. En concret, l’ADAM17 és el membre de la família millor estudiat. Aquest, es troba altament expressat en les cèl·lules dels túbuls distals i augmenta la seva expressió en totes les cèl·lules del ronyó en la malaltia renal crònica (MRC), la nefropatia diabètica (ND) i la malaltia cardiovascular (CV), entre d’altres. Basant-nos en aquests antecedents, es van dissenyar tres estudis per aquesta tesi doctoral. En primer lloc, es va analitzar l’ac

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10

Satou, Yuuki. "Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225471.

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11

PARODI, EMANUELE LUIGI. "Toll-like receptor 4 signalling mediates inflammation in skeletal muscle of patients with chronic kidney disease." Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/943048.

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12

Zabel, Rachel Eve. "New insights into appetite, inflammation and the use of fish oil in hemodialysis patients." Thesis, Queensland University of Technology, 2009. https://eprints.qut.edu.au/30248/1/Rachel_Zabel_Thesis.pdf.

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Protein-energy wasting (PEW) is commonly seen in patients with chronic kidney disease (CKD). The condition is characterised by chronic, systemic low-grade inflammation which affects nutritional status by a variety of mechanisms including reducing appetite and food intake and increasing muscle catabolism. PEW is linked with co-morbidities such as cardiovascular disease, and is associated with lower quality of life, increased hospitalisations and a 6-fold increase in risk of death1. Significant gender differences have been found in the severity and effects of several markers of PEW. There have b

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13

Zabel, Rachel Eve. "New insights into appetite, inflammation and the use of fish oil in hemodialysis patients." Queensland University of Technology, 2009. http://eprints.qut.edu.au/30248/.

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Protein-energy wasting (PEW) is commonly seen in patients with chronic kidney disease (CKD). The condition is characterised by chronic, systemic low-grade inflammation which affects nutritional status by a variety of mechanisms including reducing appetite and food intake and increasing muscle catabolism. PEW is linked with co-morbidities such as cardiovascular disease, and is associated with lower quality of life, increased hospitalisations and a 6-fold increase in risk of death1. Significant gender differences have been found in the severity and effects of several markers of PEW. There have b

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14

Söderblom, Tomas. "Effects of bacterial toxins on calcium homeostasis in renal inflammation /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-904-8/.

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15

Lobry, Tatiana. "Cystinosis : new findings involving inflammation in the kidney pathogenesis and preclinical studies for autologous hematopoietic stem cell gene therapy." Thesis, Brest, 2019. http://www.theses.fr/2019BRES0011.

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La cystinose est une maladie lysosomale héréditaire due à une mutation du gène CTNS codant pour un transporteur de cystine, cystinosin, et est caractérisée par l’accumulation de cystine dans les organes causant leur dégénération.Si le rein est le premier organe affecté par la maladie, sa pathogénèse n’est pas encore totalement comprise. La recherche de nouveaux partenaires de la cystinosine a révélé une interaction avec un membre de la famille des galactines, galectine-3 (Gal3). L’étude de cette interaction a mis en évidence un nouveau rôle de la cystinosine dans l’inflammation chronique impli

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16

Ta, Michelle Hieu Thao. "Role Of Nuclear Factor Kappa B In Polycystic Kidney Disease." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15821.

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Polycystic kidney diseases (PKDs) are a group of disorders resulting in the formation of multiple renal cysts, and are characterised by renal interstitial inflammation, cell proliferation and apoptosis. The nuclear factor (NF)-κB system regulates the transcription of genes involved in inflammation, growth and apoptosis, but it is unknown whether NF-κB has a role in the pathophysiology of PKD. Hence, the aim of this thesis was to determine the endogenous expression and activity of NF-κB in PKD, and to begin to elucidate its role in this disease. Chapter One. Chapter One demonstrates that PKD

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17

Ma, Qiuyue [Verfasser], and Hans-Joachim [Akademischer Betreuer] Anders. "The effects of hyperuricemia on sterile inflammation during chronic kidney disease / Qiuyue Ma ; Betreuer: Hans-Joachim Anders." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1223369749/34.

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18

Yang, Bin. "Involvement of programmed cell death (apoptosis) and its regulators in experimental chronic renal scarring." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369894.

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19

Axelsson, Jonas. "Fat tissue, adipokines and clinical complications of chronic kidney disease /." Stockholm : Department of Clinical Science, Intervention and Technology, Divisions of Renal Medicine and Baxter Novum, Karolinska institutet, 2006. http://diss.kib.ki.se/2006/91-7140-653-0/.

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Moorhouse, Rebecca Claire. "Role of the endothelin system in the development of kidney disease and the associated inflammation, hypertension and vascular dysfunction." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25867.

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Cardiovascular disease (CVD) is highly prevalent in chronic kidney disease (CKD) patients. Whilst this can in part be explained by the high incidence of traditional CVD risk factors such as hypertension and diabetes evident in CKD patients, recent focus has been on non-traditional risk factors and their role in CVD progression. These include endothelial dysfunction, arterial stiffness, inflammation and oxidative stress. The potent vasoconstrictor endothelin-1 (ET-1) has been implicated in the pathogenesis of CKD and the CVD associated with it. Further understanding of the mechanisms by which i

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21

Nerpin, Elisabet. "The Kidney in Different Stages of the Cardiovascular Continuum." Doctoral thesis, Högskolan Dalarna, Medicinsk vetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-209644.

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Patients with chronic kidney disease are at higher risk of developing cardiovascular disease. The complex, interaction between the kidney and the cardiovascular system is incompletely understood, particularly at the early stages of the cardiovascular continuum. The overall aim of this thesis was to clarify novel aspects of the interplay between the kidney and the cardiovascular system at different stages of the cardiovascular continuum; from risk factors such as insulin resistance, inflammation and oxidative stress, via sub-clinical cardiovascular damage such as endothelial dysfunction and lef

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22

Guimaraes, AndrÃ Brito Bastos. "Modulatory effects of acupuncture and electroacupuncture in oxidative stress and acute inflammation induced by depression experimental in rat kidney." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=17747.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>Depression is a term used by health professionals to describe a spectrum of mood changes, varying in characteristics, intensity and duration. Exposure to chronic stress can trigger long-term or permanent changes in the physiological, behavioral and emotional responses that influence susceptibility and the evolution of disease. Studies have shown that prolonged exposure to psychological stressors may increase the risk of disease due to increased production of oxidizing substances and the resulting oxidative damage. Moderate chronic s

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23

Wozniak, Justyna Verfasser], Ralph [Akademischer Betreuer] [Panstruga, and Andreas [Akademischer Betreuer] Ludwig. "Cell-specific role of ADAM10 and ADAM17 in acute and chronic kidney inflammation / Justyna Wozniak ; Ralph Panstruga, Andreas Ludwig." Aachen : Universitätsbibliothek der RWTH Aachen, 2021. http://d-nb.info/1238235395/34.

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Burton, Christopher John. "The role of proteinuria and proximal tubular cells in the development of tubulointerstitial inflammation and scarring in the kidney." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/34292.

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Loss of renal function in chronic kidney disease is correlated with interstitial scarring but the mechanism for the development of interstitial pathology in glomerular disease is unknown. Since the quantity of proteinuria, in renal disease, is correlated with the rate of progression of renal failure it has been suggested that proteinuria may be a cause of progression. Proteinuria could have this effect by altering proximal tubular cell biology resulting in inflammation and scarring in the tubulointerstitium. The experiments described in this thesis investigated alterations in the phenotype of

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25

Cardinal, Heloise. "The influence of chronic kidney disease, apoptosis and inflammation biomarkers on the diagnosis, prognosis and management of acute coronary syndromes." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107606.

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Acute coronary syndrome (ACS) results from the occlusion of coronary vessels leading to ischemia in distal cardiac muscle. When ischemia is severe enough to cause myocardial cell death by necrosis, myocardial infarction (MI) is diagnosed, whereas milder cases lead to unstable angina (UA). Challenges in the diagnosis of ACS are important, as the clinical presentation can be atypical and circulating levels of troponin are normal at the time of presentation in 50% of patients with MI. The identification of high-risk patients is also important, in order to select those who will benefit from invasi

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Degaspari, Sabrina. "Alteração na sinalização inflamatória e na proteína Klotho em pacientes com Doença Renal Crônica (DRC), em hemodiálise, na presença e ausência de déficit cognitivo e em modelo animal de DRC (nefrectomia 5/6)." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-15032014-100358/.

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DRC é a condição que descreve alteração irreversível da função renal, desencadeando o desenvolvimento de vários sintomas neurológicos. Dentre as hipóteses estão o estresse oxidativo, a resposta inflamatória e a Klotho envolvidos na patogênese tanto da DRC quanto das lesões relacionadas à Demência Vascular. O objetivo deste trabalho é o de avaliar a ausência e presença de déficit cognitivo (CI) em pacientes com DRC em hemodiálise, bem como em modelo animal de 5/6 de ablação renal (Nx), relacionando a concentração de citocinas e klotho em soro, líquor de rato e homogenato de tecido cerebral e re

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Righi, Samuel. "Increased Circulatory Lipopolysaccharide From a High Fat Diet Aggravates Inflammation and Exacerbates Renal Failure." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3444.

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Kidney failure is frequently associated with the risk factors linked to metabolic syndrome. Lipopolysaccharide (LPS) is a potent inflammatory molecule, which has increased absorption from the gut into blood circulation following a high fat and high-energy diet. We hypothesized that LPS from a high fat diet can amplify inflammation, thereby exacerbating chronic kidney disease and associated disorders. We have found that adding a high fat diet to renal insufficient mice significantly progressed their kidney disease as well as associated disorders, compared to both a high fat diet and renal insuf

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Roger, Elena. "Rôle de la Connexine 43 dans les maladies rénales tubulaires expérimentales." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS202.pdf.

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La maladie rénale chronique (MRC) est un problème majeur pour la santé publique, affectant des millions de personne dans le monde. Même si des progrès significatifs ont été réalisés, il n'existe aucun traitement spécifique permettant d'empêcher sa progression de manière probante, la découverte de nouvelles cibles thérapeutiques devenant cruciale pour mettre au point un traitement efficace. Notre objectif principal est de définir le rôle de la Connexine 43 (Cx43), protéine constitutive des jonctions gap, dans l'adaptation fonctionnelle et structurelle du rein en réponse à des agressions chroniq

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Björklund, Fredrik. "Platelet reactivity and comorbidities in acute coronary syndrome." Doctoral thesis, Umeå universitet, Institutionen för folkhälsa och klinisk medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51096.

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Background In the event of an acute coronary syndrome (ACS), the risk of death and complications such as stroke and re-infarction is high during the first month. Diabetes, impaired kidney function, elevated markers of systemic inflammation and high level of platelet reactivity have all been associated with worsened prognosis in ACS patients. Impaired kidney function is a condition with high cardiovascular morbidity and there is an established association between level of kidney function and outcome in the event of an ACS. Aims We sought to investigate the level of platelet reactivity during th

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Zimmerman, Danielle. "The Role of Angiotensin-(1-7) in a Mouse Model of Renal Fibrosis." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23692.

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Angiotensin-(1-7) [Ang-(1-7)] is a heptapeptide component of the renin angiotensin system and the endogenous ligand for the Mas receptor. Ang-(1-7) is generated mainly via angiotensin converting enzyme 2 (ACE2)-dependent cleavage of Angiotensin (Ang) II. Studies suggest Ang-(1-7) may protect against progression of renal injury in experimental models of chronic kidney disease, although the responses may be dose dependent. The role of Ang-(1-7) in the progression of renal fibrosis in unilateral ureteral obstruction (UUO) remains unclear. We tested the hypothesis that endogenous Ang-(1-7) and low

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Avila, Victor Ferreira de. "Modelo de hipertensão arterial decorrente do bloqueio de NF-kB durante a nefrogênese: efeito da sobrecarga salina." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-22102018-125017/.

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Recentemente descrevemos que ratos tratados com o inibidor do sistema NF-?B pirrolidina ditiocarbamato (PDTC) durante a lactação desenvolvem uma hipertensão arterial na fase adulta, sem lesão renal aparente, caracterizando assim um novo modelo hipertensão essencial. No presente estudo, nós investigamos se a Uninefrectomia (UNx) associada a uma sobrecarga salina (SS) na dieta revelaria uma possível disfunção renal, agravando assim a hipetensão arterial e levando a lesões renais. Ratos Munich-Wistar recém-nascidos foram divididos em 2 grupos: Controle, sem qualquer tratamento; e PDTCLact, recebe

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Bouvier, Nicolas. "Conséquences rénales de l’activation de la réponse UPR (Unfolded protein response) par des stress toxique et ischémique." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P626/document.

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Le rein natif et le greffon rénal peuvent être soumis à de multiples agressions conduisant à la détérioration progressive du parenchyme. Ces agressions peuvent être spécifiques (stress toxique, immunologique) et/ou non spécifiques (stress ischémique) et vont engendrer des réponses pouvant entraîner à la fois une diminution de la consommation d’énergie, une augmentation des apports afin de maintenir l’homéostasie tissulaire et la survie mais aussi une réaction inflammatoire et l’apoptose pouvant conduire à la fibrose. Parmi celles-ci, on peut nommer les voies HIF1α, mTOR, le stress du réticulum

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Cardoso, Carolina de Barros Morais. "Influência da insuficiência renal aguda na severidade da periodontite apical /." Araçatuba, 2019. http://hdl.handle.net/11449/182956.

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Orientador: Luciano Tavares Angelo Cintra<br>Banca: Gustavo Sivieri de Araújo<br>Banca: Suely Regina Mogami Bomfim<br>Resumo: Objetivo: Este trabalho teve como objetivo verificar a influência da Insuficiência Renal Aguda (IRA) na severidade da periodontite apical (PA) em Ratos Wistar. Métodos: Foram utilizados sessenta e quatro ratos divididos em 4 grupos e 2 períodos de análise (n=8): Controle (C), IRA, PA e IRA+PA. A IRA foi induzida por meio de uma aplicação diária de Gentamicina (100 mg/Kg/dia) durante 8 dias, via intraperitoneal. A PA foi induzida pela exposição pulpar dos primeiros e seg

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Teissier, Thibault. "Implication of the receptor for advanced glycation end-products (RAGE) during inflammation and ageing." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S017.

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Le vieillissement est défini par l’accumulation d’événements menant à une perte d’efficacité des fonctions des organes et à une augmentation de la probabilité de mourir avec le temps. Ce processus touche tout le règne animal et bien que sa vitesse varie largement entre les espèces, modifiant grandement la longévité, ses mécanismes sont quant à eux bien conservés. Chez l’humain, l’espérance de vie a continuellement progressé au cours du siècle dernier, s’accompagnant d’une augmentation de personnes atteintes de maladies liées à l’âge et dépendantes, devenant ainsi un problème majeur de société.

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DOURADO, Marclébio Manuel Coêlho. "Níveis séricos de prolactina e marcadores inflamatórios em pacientes com doença renal crônica." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/17954.

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Submitted by Irene Nascimento (irene.kessia@ufpe.br) on 2016-10-06T17:36:12Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) PPG CCS Mestrado MARCLEBIO JUL2016.pdf: 4899039 bytes, checksum: 6ddba26db5ccea9cfece89934d95f230 (MD5)<br>Made available in DSpace on 2016-10-06T17:36:12Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) PPG CCS Mestrado MARCLEBIO JUL2016.pdf: 4899039 bytes, checksum: 6ddba26db5ccea9cfece89934d95f230 (MD5) Previous issue date: 2016-07-08<br>A doença renal crônica

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Roza, Noemí Angélica Vieira 1980. "Ingestão materna crônica de dieta hiperlipídica = efeito sobre a função renal, o metabolismo glicídico e a pressão arterial da prole." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309929.

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Orientadores: Jose Antonio Rocha Gontijo, Adrianne Christine Palanch<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-18T20:30:12Z (GMT). No. of bitstreams: 1 Roza_NoemiAngelicaVieira_M.pdf: 2449991 bytes, checksum: 0b5ad477d60fbc3b8e8d3c108d67f620 (MD5) Previous issue date: 2011<br>Resumo: A prevalência de doenças cardiovasculares e obesidade esta associada ao aumento da ingestão de alimentos hipercalóricos em decorrência de modificações no padrão alimentar ocorrido nas ultimas décadas. A relação entre uma di

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Yogi, Alvaro. "Mecanismos de regulação e função celular do magnésio na hipertensão induzida pela Aldosterona em um modelo genético de hipomagnesemia: papel dos canais TRPM7." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-20052009-104224/.

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Em células endoteliais e músculo liso vascular, aldosterona regula processos associados ao remodelamento vascular como crescimento, expressão de marcadores inflamatórios e estresse oxidativo. Os mecanismos exatos desses efeitos ainda são desconhecidos, mas é sugerido que o influxo de Mg2+ através recém caracterizados TRPM7 seja importante. O objetivo de nosso estudo foi determinar o papel do Mg2+ na função celular e hipertensão induzida pela aldosterona em camundongos com níveis normais (MgH) e baixos (MgL) de Mg2+. A deficiência de Mg2+ e inibição do TRPM7 aumentaram a ativação de vias pró-in

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FIGUEIREDO, Jose Luiz de. "Inibição seletiva da catepsina S atenua ateroscleroses em camundongos deficientes na apolipoproteína e com doença renal crônica." UNIVERSIDADE FEDERAL DE PERNAMBUCO, 2015. https://repositorio.ufpe.br/handle/123456789/17155.

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Submitted by Irene Nascimento (irene.kessia@ufpe.br) on 2016-06-27T19:16:23Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) José Luiz de Figueiredo_TESE DE DOUTORADO_SA.pdf: 20285168 bytes, checksum: 2ae5d11950e2cb6dc18e886511b1c189 (MD5)<br>Made available in DSpace on 2016-06-27T19:16:23Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) José Luiz de Figueiredo_TESE DE DOUTORADO_SA.pdf: 20285168 bytes, checksum: 2ae5d11950e2cb6dc18e886511b1c189 (MD5) Previous issue date: 2015-08-24<br

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ASTORI, EMANUELA. "IN VITRO AND IN VIVO APPROACHES TO STUDY OXIDATIVE STRESS, ANEMIA AND DYSBIOSIS IN CHRONIC KIDNEY DISEASE." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/818976.

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CKD is diagnosed when there’s a decreased kidney function shown by a GFR less than 60 ml / min (established for a reference man with 1.73 m² body surface area), or markers of kidney damage, or both, of at least 3 months duration. The severity of complications increases in parallel with the GFR decline. We focused on three comorbidities extremely common in CKD patients: oxidative stress and inflammation; anemia and dysbiosis. We investigated these CKD comorbidities both with in vitro and in vivo approaches. More in detail, regarding in vivo studies, we measured oxidative stress biomarkers in a

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Aubert, Vivien. "Lésions d'ischémie-reperfusion rénale en transplantation : modélisation par agents des effets de l’oxygénation sur la dynamique cellulaire-tissulaire de l'inflammation et de la fibrose." Thesis, Poitiers, 2015. http://www.theses.fr/2015POIT1405/document.

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En préservation-transplantation rénale, l’ischémie-reperfusion (IR) induit inflammation, fibrose, dysfonction et perte du greffon. Les événements d’IR sont de mieux en mieux identifiés, mais leurs complexité limite prédiction et thérapeutique. A partir d’une analyse bibliographique détaillée, nous proposons un modèle par agents de la réponse rénale aux lésions d’IR au niveau cellulaire/tissulaire, réalisé avec l'outil de modélisation NetLogo.Dans un premier temps, nous développons un modèle dynamique de l’oxygénation du cortex rénal, avec apport et diffusion de l’oxygène (O2), et consommation

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Guebre-Egziabher, Fitsum. "Modulation de l’apport en acides gras polyinsaturés n-3 : intérêt chez le sujet sain et au cours de l’insuffisance rénale chronique." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10126/document.

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Les omégas trois ont un bénéfice prouvé dans la prévention de maladie cardiovasculaire et l’inflammation. Un apport optimal peut être réalisé avec des modifications diététiques simples permettant d’avoir un enrichissement des membranes cellulaires et un effet métabolique. Le tissu adipeux de part son rôle important dans la genèse du syndrome métabolique semble être une cible importante du traitement par oméga trois. Les patients avec une maladie rénale chronique (MRC) ont un risque cardiovasculaire accru et cumulent les perturbations métaboliques comme le syndrome métabolique et un état micro

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Carabén, Redaño Anna. "Contribución de la inflamación del aloinjerto renal a la inflamación sistémica." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/669496.

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El transplantament renal ha permès millorar la supervivència i la qualitat de vida dels pacients amb malaltia renal crònica ja que disminueix la mortalitat respecte als pacients en diàlisis. Malgrat això, la malaltia cardiovascular constitueix la primera causa de defunció del pacient després del trasplantament renal i està associada a la presència d'inflamació sistèmica (nivells elevats de proteïna C reactiva o de la interleucina 6 en sang). La nostra hipòtesi sosté que la inflamació a nivell de l'empelt renal contribueix a la inflamació sistèmica. S'han inclòs a 236 pacients portadors d'un

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Junior, Antonio Carlos Cordeiro Silva. "Influência do transplante renal e de polimorfismos genéticos nos níveis de proteína C reativa em pacientes com doença renal crônica." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-04042008-152042/.

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Avaliamos a influência do transplante renal (Tx) e de \"polimorfismos de nucleotídeos isolados\" (SNPs), na região promotora do gen codificador da proteína C reativa, sob os níveis de PCR, em 50 pacientes com doença renal crônica em terapia dialítica. Os níveis de PCR foram avaliados no período pré-Tx, no primeiro e segundo anos pós-Tx. Inicialmente, os pacientes foram divididos em três grupos de acordo com os percentis (25, 50 e 75) dos níveis de PCR no período pré-Tx. Em seguida, avaliamos os genótipos para 2 SNPs, um bi-alélico na posição -409 (G->A) e um tri-alélico (C->T->A) na posição -3

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Carron, Clémence. "Exploration des facteurs impliqués dans l'immunosenescence et l'inflammation chronique après transplantation rénale : focus sur le rôle potentiel de la translocation bactérienne digestive et les modifications du microbiote intestinal." Thesis, Bourgogne Franche-Comté, 2017. http://www.theses.fr/2017UBFCE001/document.

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Notre équipe a précédemment rapporté que l'utilisation d'un traitement d'induction lympho-déplétant [les globulines anti-lymphocytaires polyclonales (GALP)], peut entrainer une lymphopénie T CD4 persistante chez certains transplantés rénaux. Celle-ci est associée à certaines anomalies biologiques telles que la présence d'un syndrome inflammatoire chronique. Ce travail de thèse s'intéresse aux facteurs impliqués dans l'induction de ces anomalies puisqu'elles sont associées à une augmentation de l'incidence d'infections, de maladies cardiovasculaires et de décès, habituellement retrouvés chez le

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Minatel, Rosana de Fátima. "Efeito da suplementação com fibra alimentar na inflamação e dislipidemia de pacientes com doença renal crônica." Botucatu, 2020. http://hdl.handle.net/11449/192333.

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Orientador: Marina Nogueira Berbel Bufarah<br>Resumo: INTRODUÇÃO: A Doença Renal Crônica (DRC) apresenta alta prevalência global, sendo a doença cardiovascular (DCV) sua principal causa de morbidade e mortalidade. A dislipidemia e a inflamação são importantes fatores de risco cardiovascular nessa população, que podem ser atenuados com o aumento da ingestão de fibras alimentares. OBJETIVOS: Avaliar o efeito da suplementação de fibra alimentar na inflamação e dislipidemia de pacientes com doença renal crônica pré dialítica, bem como em outros parâmetros laboratoriais e nutricionais. MÉTODOS: Foi

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Souza, Viviane Angelina de. "Avaliação de sarcopenia em pacientes com doença renal crônica pré-dialítica." Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/6504.

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Submitted by Geandra Rodrigues (geandrar@gmail.com) on 2018-03-26T18:48:44Z No. of bitstreams: 0<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2018-03-27T14:06:54Z (GMT) No. of bitstreams: 0<br>Made available in DSpace on 2018-03-27T14:06:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-10-26<br>A Sarcopenia é uma condição crônica associada ao envelhecimento e caracterizada por redução da massa muscular, força e função. A prevalência de sarcopenia em pacientes com doença renal crônica (DRC) é aumentada e associa-se ao aumento da morbimorta

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Scapini, Gustavo. "Efeito da solução salina hipertônica associada à pentoxifilina sobre a lesão renal aguda após obstrução e isquemia intestinal em ratos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-09082016-155333/.

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Introdução: O tratamento da lesão renal aguda decorrente do processo inflamatório sistêmico e sepse é um desafio à prática clínica. A reanimação volêmica promove o aumento da sobrevida e menos complicações sistêmicas. Entretanto, persiste a controvérsia sobre qual o melhor fluido para a reposição e outras medicações que possam auxiliar nessa terapêutica. O objetivo deste estudo é avaliar os efeitos do Ringer lactato, da solução salina hipertônica e da pentoxifilina sobre a lesão renal aguda decorrente da obstrução e isquemia intestinal, em um modelo experimental. Métodos: Foram utilizados rato

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Farage, Najla Elias. "Expressão dos fatores transcricionais Nrf2 e Nf-κB e associação com estado nutricional em pacientes renais crônicos em hemodialise". Niterói, 2016. https://app.uff.br/riuff/handle/1/4615.

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Submitted by Ana Lúcia Torres (bfmhuap@gmail.com) on 2017-09-22T15:59:18Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese NAJLA ELIAS.pdf: 1444086 bytes, checksum: 1cddb53b806739f4425e68e8b1ca11dd (MD5)<br>Approved for entry into archive by Ana Lúcia Torres (bfmhuap@gmail.com) on 2017-09-22T15:59:42Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese NAJLA ELIAS.pdf: 1444086 bytes, checksum: 1cddb53b806739f4425e68e8b1ca11dd (MD5)<br>Made available in DSpace on 2017-09-22T15:59:42Z (GMT). N

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GRASSELLI, CHIARA. "Biological conditions related to frailty and their effects on adult renal stem cells cultured as nephrospheres." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/360937.

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La fragilità è una sindrome geriatrica definita da un progressivo declino età-correlato di diverse facoltà fisiologiche, che si traduce in una ridotta funzionalità d’organo e in un’aumentata vulnerabilità in condizioni di stress. Fried e coll. propongono una definizione operativa delle fragilità. La letteratura riporta un’alta prevalenza di fragilità in individui affetti da insufficienza renale cronica. Tra questi soggetti, il rischio di sviluppare fragilità è aumentato di due/tre volte rispetto ai soggetti sani. Ad oggi, la definizione e la valutazione della fragilità in questi pazienti è anc

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Magalhães, Luciene Pereira. "Análise dos fatores preditores de mortalidade em pacientes incidentes em hemodiálise." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-02052016-095052/.

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Introdução: A doença renal crônica afeta de 10 a 15 % da população adulta mundial e a piora da função renal, se associa com várias complicações, tais como: desnutrição, inflamação, doenças cardiovasculares e distúrbios do metabolismo mineral. A mortalidade desses pacientes é elevada sendo de 6 a 8 vezes maior que a de indivíduos saudáveis. Cerca de 22% dos pacientes incidentes, ou seja, no primeiro ano de diálise, vão a óbito. O objetivo do presente estudo foi avaliar as características clínicas, laboratoriais de pacientes incidentes em diálise além de identificar fatores de risco que contribu

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