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Rozprawy doktorskie na temat „Killer cells”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 20 lutego 2023

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1

El-Sherbiny, Yasser Mohamed. "Natural killer cells and plasma cell neoplasia." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438481.

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Chisholm, S. E. "Natural killer cell recognition of virally infected cells." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597615.

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Natural killer (NK) cells are known to be important for the control of viral infections, particularly infection with large double stranded (ds)DNA viruses such as herpes simplex virus type 1 (HSV-1) and vaccinia virus (VV), but the pathways and interactions important for NK cell recognition of virally infected cells are not well understood. Thus, the aim of this thesis was to study the molecular mechanisms of NK cell recognition of target cells infected with either HSV-1 or VV. Experiments using a set of HSV-1 mutants, deficient in one or more of the immediate early (IE) genes, demonstrated th

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3

Nassiry, Ladan 1962. "Kinetics of Natural Killer (NK) cells in mice having elevated Natural Killer cell activity." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65512.

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4

Damico, Nicole. "Preparing and Cloning a Natural Killer Cell Hybridoma." Youngstown State University / OhioLINK, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1004458025.

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Mahmood, Sajid. "Diverse regulation of natural killer cell functions by dendritic cells." Public Library of Science, 2012. http://hdl.handle.net/1993/23963.

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Natural killer (NK) cells are innate lymphocytes with inherent ability to eliminate infected cells and produce several cytokines/chemokines. They express surface receptors to sense environment and interact with other immune cells including the Dendritic cells (DC). Reciprocally, DCs are also shown to activate NK-cells. NK/DC cross-talk is well-documented, yet the molecular interactions and the diverse NK-cell activities regulated by DC remain unclear. Several target proteins such as MHC-1, Qa-1 mediate NK-cell target recognition. One such antigen, Ocil/Clr-b functions as a cognate ligand o

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6

Evans, James Henry. "The interactions of human Natural Killer cells with accessory cells." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6374.

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Natural Killer (NK) cells are lymphocytes of the innate immune system. However, there is increasing evidence that they can also play important roles in the adaptive immune system; as initiators, through antigen presentation; as effectors, via early release of IFN-y; and as immunoregulators, by eliminating over-activated macrophages. The functions of NK cells in these roles are intimately linked to their interactions with other cells during an immune response, for example recognition of target cells via activating receptors. The activating receptor NKG2D recognises proteins that are not normall

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El-Jawhari, Jehan Jomaa El-Said. "Tumour-mediated inhibition of natural killer cells." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590426.

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The critical role of immune cells, in particular NK cells and cytotoxic T lymphocytes in recognition and elimination of tumour cells has been clearly demonstrated. However, immune evasion is a central hallmark of cancer; it negatively influences the prognosis and efficiency of therapies. Thus, understanding of this process will help to improve cancer therapy. Genetic alterations such as activation of oncogenes and loss of tumour suppressor genes are highly implicated in carcinogenesis. This study shows that the presence of KRAS oncogene reduced the surface expression of MHC class I on colorect

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8

Suck, Garnet, Yeh Ching Linn, and Torsten Tonn. "Natural Killer Cells for Therapy of Leukemia." Karger, 2016. https://tud.qucosa.de/id/qucosa%3A71644.

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Clinical application of natural killer (NK) cells against leukemia is an area of intense investigation. In human leukocyte antigen-mismatched allogeneic hematopoietic stem cell transplantations (HSCT), alloreactive NK cells exert powerful anti-leukemic activity in preventing relapse in the absence of graft-versus-host disease, particularly in acute myeloid leukemia patients. Adoptive transfer of donor NK cells post-HSCT or in non-transplant scenarios may be superior to the currently widely used unmanipulated donor lymphocyte infusion. This concept could be further improved through transfusion

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9

Stringaris, Katherine. "Natural killer cells and acute myeloid leukaemia." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/18014.

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Despite successful induction chemotherapy, most patients with acute myeloid leukemia (AML) will relapse. Immune surveillance by T cells or natural killer (NK) cells may play a role in preventing relapse. This thesis examines the potential of NK cells to control AML. Study 1 explored in 248 patients with haematological malignancies from the US National Institutes of Health, the genetic diversity of NK killer immunoglobulin receptor (KIR) genes in patients and their stem cell donors and their impact on outcome after stem cell transplantation (SCT) for haematological malignancy. Individuals with

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10

Senff, Tina [Verfasser], and Jörg [Akademischer Betreuer] Timm. "The role of Natural Killer cells and Natural Killer T cells in HCV infection / Tina Senff ; Betreuer: Jörg Timm." Duisburg, 2018. http://d-nb.info/1153338009/34.

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11

Wolf, A. S. "Natural killer cell responses to Plasmodium falciparum-infected red blood cells." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2017. http://researchonline.lshtm.ac.uk/3449324/.

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NK cells are known to respond in vitro to P. falciparum-infected red blood cells (iRBCs), although responses are highly heterogeneous between donors. Although their role during malaria infection is not fully understood, they may play a role in cytokine production during early infection, and furthermore may interact with and kill iRBCs. The work described in this thesis examines the role of NK cell receptors in determining the functional outcomes of NK cell activation by iRBCs, focusing on NK cell responses to exogenous cytokines and the phenotypic and functional profiles of NK cells from malar

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12

Walwyn-Brown, Katherine. "Control of Th2 polarisation by dendritic cells and natural killer cells." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/control-of-th2-polarisation-by-dendritic-cells-and-natural-killer-cells(fd15f834-f926-40f1-88ff-217bf1fbf263).html.

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Type 2 (Th2) immune responses are required for immune defence against helminths, but can also have pathogenic effects in allergic conditions. This thesis examined two factors which may influence Th2 immunity at a cellular and molecular level: cross-talk between Natural Killer (NK) cells and dendritic cells (DCs) and the cell surface organisation of DCs. Cross-talk between NK cells and DCs is well-established to impact Th1 responses against tumours and infection; however the influence of this interaction during Th2 inflammation is unknown. To investigate this, human monocyte-derived DCs were st

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13

Liang, Huyi, and 梁湖沂. "Enterovirus 71 directly infects human natural killer cells and induces cell apoptosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hdl.handle.net/10722/208428.

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Enterovirus 71 (EV71) belongs to the Enterovirus genus of the family Picornaviridae and is the major causative agent of hand, foot and mouth disease (HFMD). Although clinical manifestations of HFMD are usually mild and self-limiting, severe HFMD patients suffer from a diverse array of neurological diseases and sometimes these diseases are fatal. HFMD usually occurs in young children and gradually becomes a new threaten in Asia. Unfortunately, effective EV71 vaccine is not available to date and alternative treatments are still in debate. This is partially due to the lack of understanding

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14

Tabayoyong, William Borj. "Engraftment of embryonic stem cell-derived hematopoietic progenitor cells is regulated by natural killer cells." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1089.

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Embryonic stem (ES) cells possess the remarkable ability to form cells and tissues from all three germ layers, a characteristic known as pluripotency. In particular, the generation of ES cell-derived hematopoietic cells could serve as an alternate source of hematopoietic stem cells for transplantation in place of bone marrow cells, which are limited by donor availability and high immunogenicity. The advantages of ES cell-derived hematopoietic cells over bone marrow cells include a greater proliferative capacity, which alleviates the problems of donor shortage, and low level expression of MHC a

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15

Kurioka, Ayako. "Mucosal associated invariant T cells and CD161 expressing natural killer cells." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:f994e661-d241-4a1c-ac56-b6bea73346ac.

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Mucosal-associated invariant T (MAIT) cells are a population of innate-like lymphocytes within the gut, liver and blood, expressing a semi-invariant T cell receptor (TCR) and high levels of the C-type lectin-like receptor, CD161. These cells recognise a metabolite of the microbial riboflavin synthesis pathway, presented by the highly conserved Major Histocompatibility Complex (MHC) class I-related protein, MR1, and are critical for the control of bacterial infections. The factors regulating the broad effector functions of MAIT cells have not been fully investigated. Utilising a novel flow cyto

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16

Hook, C. E. "Interactions between human natural killer cells and Chlamydia trachomatis infected cells." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604208.

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<I>Chlamydia trachomatis</I> (CT) is an obligate intracellular bacteria and is a common cause of ocular and genital infections in human populations. Murine models of CT infection have shown that Natural Killer cells (NK cells) are recruited into the genital tract early after infection, and are an important source of the cytokine IFN-γ. NK cells are part of the innate defences against infection through cytokine production (IFN-γ, TNF-α and GM-CSF) and cytolytic activity. The hypothesis investigated in this thesis was that CT-infection of target cells leads to alterations in the target cell that

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17

Wehner, Rebekka, Kristin Dietze, Michael Bachmann, and Marc Schmitz. "The Bidirectional Crosstalk between Human Dendritic Cells and Natural Killer Cells." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-137394.

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Dendritic cells (DCs) are professional antigen-presenting cells, which display an extraordinary capacity to induce T-cell responses. Recent findings revealed that DCs also play a crucial role in the activation of natural killer (NK) cells representing important effectors in the innate immune defense against viruses and tumors. Here, we summarize various studies investigating the bidirectional crosstalk between human DCs and NK cells. In this context, it has been reported that DCs efficiently enhance CD69 expression, proliferation, interferon (IFN)-γ secretion and cytotoxic activity of NK cells

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18

Wehner, Rebekka, Kristin Dietze, Michael Bachmann, and Marc Schmitz. "The Bidirectional Crosstalk between Human Dendritic Cells and Natural Killer Cells." Karger, 2011. https://tud.qucosa.de/id/qucosa%3A27732.

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Dendritic cells (DCs) are professional antigen-presenting cells, which display an extraordinary capacity to induce T-cell responses. Recent findings revealed that DCs also play a crucial role in the activation of natural killer (NK) cells representing important effectors in the innate immune defense against viruses and tumors. Here, we summarize various studies investigating the bidirectional crosstalk between human DCs and NK cells. In this context, it has been reported that DCs efficiently enhance CD69 expression, proliferation, interferon (IFN)-γ secretion and cytotoxic activity of NK cells

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19

Siu, Lai-ping Lisa. "The molecular pathology of natural killer cell malignancies /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25205195.

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20

Parsons, Matthew. "Lessons learned: natural killer cell education as a determinant of the anti-viral functional potential of natural killer cells." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114492.

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A vaccine against the human immunodeficiency virus (HIV) is urgently needed. Recent estimates predict that 34 million people are currently infected with HIV. Attempts to induce potentially protective cytotoxic T-lymphocytes or broadly neutralizing antibodies by vaccination have either proven unsuccessful or failed to elicit the desired immune responses. However, the recent RV144 vaccine trial that provided partial protection against HIV infection appears to have induced antibodies that can utilize cells of the innate immune system, such as natural killer (NK) cells, to mediate antibody-depende

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21

Troke, Angela D. "Investigation of the expression of leukophysin, a novel granule-associated protein, in natural killer cells and lymphokine-activated killer cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0021/MQ57334.pdf.

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22

Zhu, Yanting. "Cytotoxic dynamics of natural killer cell at the single cell level." HKBU Institutional Repository, 2018. https://repository.hkbu.edu.hk/etd_oa/590.

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Natural Killer (NK) cell, a crucial player of the human innate immune defense system, detects and kills virus-infected cells and cancer cells. Although the relevant molecular machineries involved in NK cell activation and NK-target cell interactions are largely known, how their collected dynamics regulate fast yet highly selective target cell killing in the complex environment of tissues is poorly understood. In traditional bulk killing assays, heterogeneity and kinetic details of individual NK-target cell interactions are masked, seriously limiting analysis of the underlying dynamic mechanism

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23

Hüber, Christian Markus. "Investigating adaptive immunological features of natural killer cells." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708920.

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Schmidt, Brian P. "The Use of Lactate Dehydrogenase for the Detection of Murine Natural Killer Cell Function." Youngstown State University / OhioLINK, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=ysu999616997.

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Kamel, Fatemah Omar. "Invariant natural killer T cells in multiple sclerosis." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/40281.

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Invariant natural killer T (iNKT) cells are a subpopulation of lymphocytes that express both a CD1d-restricted αβ T cell receptor (TCR) and NK cell markers. iNKT cell perturbations are implicated in a wide variety of autoimmune diseases including Multiple Sclerosis (MS). Our results confirmed a significant reduction in the percentage of iNKT cells in MS patients with respect to healthy donors. In order to understand the immunological significance of iNKT cell reduction in MS, we aimed to define iNKT subsets in a cohort of MS patients of different disease types, Clinically Isolated Syndrome pat

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26

Kamya, Nabukenya. "Natural killer cells in HIV infected slow progressors." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104518.

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Acquired immunodeficiency syndrome AIDS-related illnesses are a leading cause of infectious disease mortality worldwide. The development of a safe and effective prophylactic HIV vaccine is an imperative global public health priority fraught with significant obstacles because the answers to fundamental immunological questions remain unknown. One such gap in knowledge includes the identification of the elusive correlates of immune protection against HIV.Untreated HIV infection is characterized by severe dysregulation of the antiviral immune response that begins during the earliest stages of infe

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Norgate, Zoe. "Gene expression in rat uterine natural killer cells." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614884.

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Wantoch, Michelle Hannah. "Activation of natural killer cells by oncolytic viruses." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/21629/.

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Campbell, Tessa Mollie. "On interactions between alphaherpesviruses and natural killer cells." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20929.

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Natural killer (NK) cells are a critical component of the innate immune response to viral infection. NK cells are responsible for the early control of virus spread, cytolytically killing infected cells, as well as secreting proinflammatory cytokines to enhance immune responses. In patients with deficiencies in NK cell function, there is an extreme susceptibility to infection with herpesviruses, in particular, varicella zoster virus (VZV) and herpes simplex virus type 1 (HSV-1). These two medically important human alphaherpesviruses cause widespread disease in human hosts, with VZV being the ca

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Belfrage, Hans. "Activation of murine cytotoxic cells with interleukin-2 and the bacterial superantigen staphylococcal enterotoxin A." Lund : Dept. of Cell & Molecular Biology, Section of Tumor Immunology, the Wallenberg Laboratory, 1996. http://catalog.hathitrust.org/api/volumes/oclc/38037867.html.

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Assarsson, Erika. "Acquisition and function of NK cell-associated molecules on T cells /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-487-9/.

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黃傑煇 and Kit-fai Wong. "CD56-positive: natural killer cell lymphoma/leukaemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3198177X.

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Wong, Kit-fai. "CD56-positive natural killer cell lymphoma/leukaemia /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23736197.

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Magri, Giuliana. "Characterization of natural Killer cell response to human cytomegalovirus infected dentrilic cells." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/38527.

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S'ha establert un sistema experimental autòleg per a poder estudiar la resposta de les cèl.lules Natural Killer (NK) contra les cèl.lules dendrítiques derivades de monòcits (moDC), infectades pel Cytomegalovirus humà (HCMV). Els nostres resultats mostren que les cèl.lules NK responen contra les moDC infectades per HCMV, que presenten una expressió de les molècules MHC de classe I a superficie reduïda. Específicament, demostrem que la infecció per HCMV disminueix l'expressió en superficie d'HLA-E en les moDC, alliberant així la inhibició de les cèl.lules NK NKG2A+. Mostrem que els NKR anomenats

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Magri, Giuliana. "Characterization of natural Killer cell response to human entomegalovirus infected dentrilic cells." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/38527.

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S'ha establert un sistema experimental autòleg per a poder estudiar la resposta de les cèl.lules Natural Killer (NK) contra les cèl.lules dendrítiques derivades de monòcits (moDC), infectades pel Cytomegalovirus humà (HCMV). Els nostres resultats mostren que les cèl.lules NK responen contra les moDC infectades per HCMV, que presenten una expressió de les molècules MHC de classe I a superficie reduïda. Específicament, demostrem que la infecció per HCMV disminueix l'expressió en superficie d'HLA-E en les moDC, alliberant així la inhibició de les cèl.lules NK NKG2A+. Mostrem que els NKR anomenats

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Bowles, Paul Anthony. "Natural killer cell recognition and killing of virally-transformed and cancer cells." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550269.

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Natural Killer (NK) cells are important in the elimination of virally-infected and cancer cells. NK cell recognise changes in surface molecules on cells, which can cause an NK cell to kill the target cell by either ligation of death receptors or perforin-mediated release of granzymes. Granzymes are serine proteases that cleave numerous cellular proteins that are important in co-ordinating cell death in the target cell. Induction of apoptosis involves dysregulation of cellular machinery including disruption of mitochondrial membrane potential, nuclear fragmentation and cell membrane permeabilit

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Pfeifer, Caroline [Verfasser], and Marcus [Akademischer Betreuer] Altfeld. "Association between Natural Killer Cell Education and Cellular Glucose Metabolism in Human Natural Killer Cells / Caroline Pfeifer ; Betreuer: Marcus Altfeld." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1179362616/34.

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Li, Peng. "Reprogramming of T cells to natural killer-like cells upon BCL11B deletion." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609198.

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Kieckbusch, Jens. "How do natural killer cells contribute to reproductive success?" Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708449.

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Parihar, Robin. "Characterization of the natural killer cell cytokine response to antibody-coated tumor cells." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1091216058.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Document formatted into pages; contains xx, 230 p. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Aug. 3.

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邵麗平 and Lai-ping Lisa Siu. "The molecular pathology of natural killer cell malignancies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31243605.

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Alici, Evren. "Therapeutic potential of natural killer cells in multiple myeloma /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-998-X/.

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Alheim, Mats. "Inhibitory receptors of natural killer cells : specificity and regulation /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19981009alhe.

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Lee, I.-Fang. "The role of natural killer cells in autoimmune diabetes." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/29156.

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Type 1 diabetes (T1D) is caused by the autoimmune destruction of insulin-producing β-cells with consequent hyperglycemia and serious chronic complications. Both innate and adaptive immune responses are involved in the pathogenesis of this disease. Studies in animal models and in patients with T1D have shown that natural killer (NK) cells are involved both in disease progression and in disease protection, thus suggesting that NK cells can represent a potential therapeutic target in this disease, once the contribution of NK cells to islet immunity has been fully elucidated. Using the model of co

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Fraser, Rupsha. "The role of decidual natural killer cells in pregnancy." Thesis, St George's, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558353.

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During pregnancy, maternal uterine spiral arteries are remodelled from minimal flow, high resistance vessels into large diameter, low resistance, high flow vessels. This change is crucial for delivery of adequate blood supply to the developing fetus, and is impaired in pregnancies complicated by pre-eclampsia. In early pregnancy, fetal trophoblasts invade into the decidua and remodel the spiral arteries. However, decidual natural killer (dNK) cells accumulate around spiral arteries and are present ahead of trophoblast invasion. Their presence is continuous during trophoblast invasion and spira

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Olofsson, Karl, and Gustav Stenbom. "Directed Migration of Natural Killer Cells by Microcontact Printing." Thesis, KTH, Tillämpad fysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-145736.

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NK cells are large granular lymphocytes that patrol the body for defect or virally infected cells. The migration of natural killer (NK) cells is critical for the detection and elimination of aberrant cells such as tumor- and virally infected cells. If a NK cell stumbles upon a target, i.e. an aberrant or stressed cell, the NK cell has the ability to kill the target cell. Limitations in the efficiency of NK cells, such as limited migration speed, and the finite number of target cells that can be killed by one NK cell, leaves the immune system vulnerable to diseases. However it has been shown th

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Artavanis-Tsakonas, Katerina. "Activation of human natural killer cells by Plasmodium falciparum." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2003. http://researchonline.lshtm.ac.uk/1520136/.

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The purpose of work described in this thesis was to (i) determine the contribution of innate immune responses to the early pro-inflammatory cytokine response to Plasmodium falciparum, (ii) describe the kinetics and cellular sources ofIFN-y production by human PBMC in response to activation by intact, infected erythrocytes (iRBC) or freeze-thawed schizont lysate (PfSL) and (iii) determine the activation requirements for innate immune cells responding to P. falciparum. Infected erythrocytes induce a more rapid and intense IFN-y response from malaria naive PBMC than does PfSL, correlating with ra

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Sekine, Takuya. "Role of natural killer cells in cord blood transplantation." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/31584.

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Cord blood transplantation (CBT) for high-risk hematologic cancers is limited by the low numbers of immune cells in a single CB unit, leading to diminished graft-versus-leukemia effect. Although natural killer (NK) cells can mediate potent graft-versus-leukemia effect, and are the first reconstituting lymphocytes after transplantation, the receptor-ligand interactions mediating their cytotoxicity are not well understood. I first studied killer-cell immunoglobulin-like receptor (KIR) and HLA genotypes, NK phenotype and function for 110 CBT recipients to identify specific patterns of KIR-HLA int

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Martelli, Serena. "Maturation and function of natural killer cells during aging." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/422259/.

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Current population aging is without parallel in human history and it brings significant socio-economic and political challenges with it. The immune system is profoundly affected during aging, a process termed immunosenescence. A hallmark of aging is the increased susceptibility to infections and cancer. Since Natural Killer (NK) cells play a critical role in immune-surveillance against virally-infected and transformed cells, a clearer understanding of the key players in NK cell maturation might help to better design innovative therapeutic strategies relevant to aging and other conditions of pe

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Pannunzio, Pardo. "Transferrin and its role in human natural killer cell binding of target cells." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61734.

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