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Rozprawy doktorskie na temat „Killer immunoglobulin like receptors (KIR)”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 1 lutego 2022

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1

Yindom, Louis Marie. "Human Leukocyte Antigen (HLA) and Killer Immunoglobulin-like Receptors (KIR) in HIV-2 Infection." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520671.

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2

Braun, Kali. "Association of killer immunoglobulin-like receptor (KIR) genes with tuberculosis disease in two Canadian cohorts." PLoS ONE, 2013. http://hdl.handle.net/1993/22042.

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In Canada, and more specifically in Canadian-born Aboriginals and foreign born populations, high incidence of tuberculosis (TB) causes significant morbidity and mortality. The presence or absence of specific killer immunoglobulin-like receptor (KIR) genes, individually or in conjunction, may be associated with tuberculosis (active, latent, or uninfected disease status) as well as ethnicity of an individual. It is hypothesized that the differences in KIR profiles, gene frequencies, and/or haplotypes in Canadian-born Aboriginal, Canadian-born non-Aboriginal, and foreign born individuals elicits

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3

Sepulveda, Christian Alberto Garcia. "Killer cell Immunoglobulin-like Receptor (KIR) polymorphism : functional implications and clinical relevance." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444690/.

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NK cell function is regulated by Killer-cell Immunoglobulin-like Receptors (KIR) some of which recognise class I Major Histocompatibility Complex molecules. KIRs have been shown to exhibit a high degree of functional diversity which is generated at several levels. However, the functional relevance of this diversity remains largely unknown. This thesis describes our approach towards elucidating the functional relevance of KIR diversity. To study this we first compiled all known KIR sequences into a database. We developed bioinformatics tools to facilitate the study of these sequences and have m

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4

Halfpenny, Iris A. "An investigation into the genetics of the killer immunoglobulin-like receptor (KIR) gene family." Thesis, University of Ulster, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494359.

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5

Foley, Bree Amanda. "The immunogenetics of natural killer cell alloreactivity." University of Western Australia. School of Pathology and Laboratory Medicine, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0242.

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[Truncated abstract] Natural killer (NK) cell alloreactivity can be exploited in haploidentical haematopoietic stem cell transplantation (HSCT) to improve graft survival, reduce graft versus host disease and decrease leukaemic relapse. NK cells lyse cells that have reduced expression of class I HLA molecules. In an allogeneic setting, donor NK cells may be activated by the absence of donor (self) class I HLA molecules on recipient cells; the absence of self-epitopes being detected by inhibitory KIR receptors on donor NK cells. The way in which genetic polymorphism of the receptors and ligands

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6

Salim, Patrícia Hartstein. "Estudo do polimorfismo dos genes KIR na esclerose sistêmica." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/15457.

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As células Natural Killer (NK) fazem parte da resposta imune inata, sendo a primeira linha de defesa do organismo contra vírus, bactérias, tumores e microorganismos. Estas células induzem a morte da célula-alvo quando não há o reconhecimento das moléculas de antígenos leucocitários humanos (HLA) de classe I, através de seus receptores, chamados Killer cell Immunoglobulin-like Receptor (KIR). Vários estudos demonstram o envolvimento dos genes KIR na patogênese das doenças auto-imunes. Acredita-se que combinações desses genes possam ser favoráveis para o desenvolvimento da esclerose sistêmica (E

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7

Ishida, Yoshihiro. "Killer immunoglobulin-like receptor genotype did not correlate with response to anti-PD-1 antibody treatment in a Japanese cohort." Kyoto University, 2020. http://hdl.handle.net/2433/253207.

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8

Silva, Pamela Portela da. "Análise de polimorfismos dos genes KIR e HLA classe I em pacientes com câncer colorretal." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/148088.

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O câncer colorretal (CCR) pode ocorrer em qualquer parte do cólon ou do reto e representa o terceiro câncer mais comum no mundo em ambos os sexos. As células Natural Killer (NK) fazem parte do sistema imune inato reconhecendo moléculas de HLA de classe I em células alvo, através de seus receptores de membrana killer cell immunoglobulin-like receptors (KIR). O objetivo deste estudo foi avaliar a associação entre os genes KIR e os ligantes HLA em pacientes com câncer colorretal e controles saudáveis. Examinamos o polimorfismo de 16 genes KIR e seus ligantes HLA em 154 pacientes caucasóides com C

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9

Silva, Pamela Portela da. "Estudo de polimorfismos dos genes KIR e HLA em pacientes com câncer de próstata." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/35890.

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O câncer de próstata é o segundo câncer mais comum entre homens, uma vez que tanto a incidência como a mortalidade aumentam exponencialmente após a idade de 50 anos. As células Natural Killer (NK) fazem parte do sistema imune inato e reconhecem moléculas de HLA de classe I na célula alvo, através de seus receptores de membrana, chamados killer immunoglobulin-like-receptors (KIR). O objetivo desse estudo foi avaliar a associação entre os genes KIR e HLA em pacientes com câncer de próstata e grupo controle. Genotipamos 200 pacientes com diagnóstico de câncer de próstata e 185 pacientes saudáveis

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10

Ichise, Hiroshi. "NK cell alloreactivity against KIR-ligand-mismatched HLA-haploidentical tissue derived from HLA haplotype-homozygous iPSCs." Kyoto University, 2017. http://hdl.handle.net/2433/228232.

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11

Jobim, Maria Regina Sampaio Leite. "Estudo do polimorfismo dos genes KIR e HLA em pacientes com câncer de mama e grupo controle." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/97026.

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O presente estudo tem como objetivo investigar a frequência dos diversos polimorfismos dos genes KIR (Killer Immunoglobulin-like Receptors) e HLA C1 e C2 em um grupo de pacientes com câncer de mama e comparar com um grupo controle de indivíduos sadios. As células natural killer (NK) são linfócitos que diferem das células T e B e que fazem parte da imunidade natural, reconhecendo as moléculas HLA (Antígenos Leucocitários Humano) de classe I em células infectadas por vírus ou em células tumorais, através de seus receptores de membrana. Os principais receptores das células NK são conhecidos como

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12

Kruse, Philip Hermann Verfasser], Lutz [Akademischer Betreuer] Walter, Jürgen [Akademischer Betreuer] [Wienands, and Wolfgang [Akademischer Betreuer] Engel. "Genetic and functional characterisation of killer cell immunoglobulin like receptors (KIR) of rhesus macaques (Macaca mulatta) / Philip Hermann Kruse. Gutachter: Lutz Walter ; Jürgen Wienands ; Wolfgang Engel. Betreuer: Lutz Walter." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2011. http://d-nb.info/1042640025/34.

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13

Martin, Hilmar. "Evaluation von KIR-Liganden Inkompatibilität bei unverwandten Knochenmark-/ Stammzelltransplantationen." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1124306558415-94790.

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We performed a retrospective study in 185 patients with myelogenous leukemias who had received hematopoietic cells from unrelated donors. The aim of this study was to answer the question wether the benefit of KIR ligand incompatibility seen in haploidentical tranplantations can also be seen using unrelated donors. We could not detect a significant difference in survival between patients with a KIR ligand incompatibility and those with either fully matched or partially mismatched unrelated donors in this patient cohort<br>In der Therapie von Leukämien ist die Knochenmark- bzw. Stammzelltranspla

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14

Abalos, Andrew T. "KILLER-CELL IMMUNOGLOBULIN-LIKE RECEPTORS AND HPV PREVALENCE AND INCIDENCE." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/145440.

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Introduction: Human papillomavirus (HPV) is the most commonly occurring sexually transmitted infection and is a necessary cause of cervical cancer. The progression from HPV infection to cervical cancer is incompletely understood. Innate immune response to HPV infection has recently been identified as a potential cofactor in this progression. This study examined potential association(s) between killer cell immunoglobulin-like receptors (KIR) and HPV infection. HPV concordance was estimated among heterosexual couples demonstrating the complexity of HPV infection.Methods: HPV concordance was cros

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15

Twigger, Katie. "The role of killer immunoglobulin-like receptors in HTLV-1 infection." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/25539.

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Human T-lymphotropic virus type 1 (HTLV-1) causes the debilitating neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of infected individuals, while the majority are lifelong asymptomatic carriers (ACs). The effectiveness of the CD8+ T-cell response to HTLV-1 is a major determinant of the HTLV-1 proviral load (PVL) and the associated HAM/TSP risk. Host genotype, particularly of HLA class I, strongly influences CD8+ T-cell effectiveness against HTLV-1. Furthermore, possession of the KIR gene 2DL2 was recently shown to enhance protective a

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16

Speidel, Frieder. "Untersuchungen zur Expression von "Killer-immunoglobulin-like-receptors" und zytotoxischer Aktivität von cytokinstimulierten NK-Zellen /." Tübingen, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253677.

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17

Moesta, Achim Klaus. "Functional specificities of killer cell immunoglobulin-like receptors for MHC-C in humans and chimpanzees /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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18

Thielens, Ariane. "Etudes pré-clinique et clinique de l'anticorps immunomodulateur Lirilumab visant à augmenter la réponse anti-tumorale des cellules NK." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4105.

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L’activité anti-tumorale des cellules NK est régulée par des récepteurs de surface activateurs et inhibiteurs qui reconnaissent des ligands exprimés par les cellules cibles. Afin d’augmenter le potentiel cytotoxique des cellules NK face à des cellules cancéreuses autologues, Innate Pharma a développé des Ac bloquant les interactions entre certains récepteurs inhibiteurs de la cellule NK, les KIRs, et leurs ligands, des molécules du CMH de classe I.Dans un premier temps, nous avons mis en place un modèle tumoral d’efficacité des Ac anti-KIR dans des souris transgéniques pour l’expression d’un K

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19

Older, Aguilar Anastazia Magdalena. "Comparison of genomic structure and MHC specificities of killer cell immunoglobulin-like receptors in humans and orangutans /." May be available electronically:, 2009. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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20

Sáez, Borderias Andrea. "Regulation of natural killer and cd4+T cell function by NKG2 C-type lectin-like receptors." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7133.

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This work is centered on the study of the NKG2 C-type lectin-like receptors on NK and CD4+T cells. We provide evidence supporting that CD4+T cells specific for Human Cytomegalovirus (HCMV) may express different NK cell receptors, and demonstrate that the C-type lectin-like receptor NKG2D is expressed on cytotoxic CD4+T cells with an effector/memory phenotype, enhancing their TCR-dependent proliferation and cytokine production. A second part of the work is centered on the study of the CD94/NKG2 receptors on NK cells. We show that NKG2A can be induced on NKG2C+ NK cells upon activation with rIL-

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21

Hermes, Meike [Verfasser], Lutz [Akademischer Betreuer] Walter, and Torben [Akademischer Betreuer] Lübke. "Characterisation of killer immunoglobulin-like receptors in rhesus macaques (Macaca mulatta) / Meike Hermes. Gutachter: Lutz Walter ; Torben Lübke. Betreuer: Lutz Walter." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1042345627/34.

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22

Suck, Garnet, Yeh Ching Linn, and Torsten Tonn. "Natural Killer Cells for Therapy of Leukemia." Karger, 2016. https://tud.qucosa.de/id/qucosa%3A71644.

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Clinical application of natural killer (NK) cells against leukemia is an area of intense investigation. In human leukocyte antigen-mismatched allogeneic hematopoietic stem cell transplantations (HSCT), alloreactive NK cells exert powerful anti-leukemic activity in preventing relapse in the absence of graft-versus-host disease, particularly in acute myeloid leukemia patients. Adoptive transfer of donor NK cells post-HSCT or in non-transplant scenarios may be superior to the currently widely used unmanipulated donor lymphocyte infusion. This concept could be further improved through transfusion

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23

Pesce, John Thomas. "Early events leading to the host protective Th2 immune response to an intestinal nematode parasite /." Download the dissertation in PDF, 2005. http://www.lrc.usuhs.mil/dissertations/pdf/Pesce2005.pdf.

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24

Hermes, Meike. "Characterisation of killer immunoglobulin-like receptors in rhesus macaques (Macaca mulatta)." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F0C1-A.

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25

Kruse, Philip Hermann. "Genetic and functional characterisation of killer cell immunoglobulin like receptors (KIR) of rhesus macaques (Macaca mulatta)." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-ADED-9.

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26

Gentle, Nikki Lynne. "The role of killer immunoglobulin-like receptors (KIR) and specific human leukocyte antigen (HLA) class I molecules in control of HIV-1 infection." Thesis, 2015. http://hdl.handle.net/10539/18671.

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A thesis submitted to the Faculty of Health Sciences, University of the Witwatersrand, in fulfilment of the requirements for the degree of Doctor of Philosophy Johannesburg 2015<br>The classical human leukocyte antigen (HLA) class I molecules are important regulators of both the adaptive and innate immune responses to viral infection. Genetic variability within these loci determines the nature of the interaction between both the T cell receptor (TCR) on CD8+ T cells and specific killer immunoglobulin-like receptors (KIR) on the surface of natural killer (NK cell). Both of these interact

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27

Albrecht, Christina. "Association of killer immunoglobulin-like receptor genes with viral loads in experimental SIV infection of rhesus macaques (Macaca mulatta)." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-EF91-8.

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28

Jesus, Kátia Ribeiro de. "Immunology and genetics in nonhuman primates: Study of KIR3DL02 interaction with MHC-class-I ligands of rhesus macaques." Master's thesis, 2018. http://hdl.handle.net/10316/82073.

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Dissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de Medicina<br>Células natural killer (NK) são linfócitos capazes de matar células alvo infectadas ou transformadas por vírus. A ativação da lise de células alvo pelas células NK é mediada pelos receptores presentes nestas células. Um grupo importante de receptores são os receptores tipo imunoglobulina das células killer (KIR), sabe-se que estes ligam a membros da família polimórfica de moléculas MHC-classe-I. O macaco rhesus foi considerado um modelo animal primata não-humano de grande importância para doenças infeciosa

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29

Hardie, Rae-Anne Michelle. "Sequence-based genotyping of killer cell immunoglobulin-like receptors and their associations with HIV-1 resistance and disease progression." 2009. http://hdl.handle.net/1993/21431.

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