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Artykuły w czasopismach na temat „L-lactate levels”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 21 lutego 2023

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1

ERDOĞAN, Hasan, Songül ERDOĞAN, Tahir Özalp, İsmail Günal, and Kerem URAL. "L-Lactate Levels Calves With Pneumonia." Journal of Advances in VetBio Science and Techniques 3, no. 2 (August 31, 2018): 38–42. http://dx.doi.org/10.31797/vetbio.433468.

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Tongyoo, Surat, Kamonlawat Sutthipool, Tanuwong Viarasilpa, and Chairat Permpikul. "Serum lactate levels in cirrhosis and non-cirrhosis patients with septic shock." Acute and Critical Care 37, no. 1 (February 28, 2022): 108–17. http://dx.doi.org/10.4266/acc.2021.00332.

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Background: In septic shock patients with cirrhosis, impaired liver function might decrease lactate elimination and produce a higher lactate level. This study investigated differences in initial lactate, lactate clearance, and lactate utility between cirrhotic and non-cirrhotic septic shock patients.Methods: This is a retrospective cohort study conducted at a referral, university-affiliated medical center. We enrolled adults admitted during 2012–2018 who satisfied the septic shock diagnostic criteria of the Surviving Sepsis Campaign: 2012. Patients previously diagnosed with cirrhosis by an ima
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Biancari, Fausto, Antonio Fiore, Kristján Jónsson, Giuseppe Gatti, Svante Zipfel, Vito G. Ruggieri, Andrea Perrotti, et al. "Prognostic Significance of Arterial Lactate Levels at Weaning from Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation." Journal of Clinical Medicine 8, no. 12 (December 15, 2019): 2218. http://dx.doi.org/10.3390/jcm8122218.

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Background: The outcome after weaning from postcardiotomy venoarterial extracorporeal membrane oxygenation (VA-ECMO) is poor. In this study, we investigated the prognostic impact of arterial lactate levels at the time of weaning from postcardiotomy VA. Methods: This analysis included 338 patients from the multicenter PC-ECMO registry with available data on arterial lactate levels at weaning from VA-ECMO. Results: Arterial lactate levels at weaning from VA-ECMO (adjusted OR 1.426, 95%CI 1.157–1.758) was an independent predictor of hospital mortality, and its best cutoff values was 1.6 mmol/L (&
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Scheijen, Jean L. J. M., Nordin M. J. Hanssen, Marjo P. H. van de Waarenburg, Daisy M. A. E. Jonkers, Coen D. A. Stehouwer, and Casper G. Schalkwijk. "L(+) and D(-) Lactate Are Increased in Plasma and Urine Samples of Type 2 Diabetes as Measured by a Simultaneous Quantification of L(+) and D(-) Lactate by Reversed-Phase Liquid Chromatography Tandem Mass Spectrometry." Experimental Diabetes Research 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/234812.

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Background. Plasma and urinary levels of D-lactate have been linked to the presence of diabetes. Previously developed techniques have shown several limitations to further evaluate D-lactate as a biomarker for this condition.Methods. D- and L-lactate were quantified using ultraperformance liquid chromatography tandem mass spectrometry with labelled internal standard. Samples were derivatized with diacetyl-L-tartaric anhydride and separated on a C18-reversed phase column. D- and L-lactate were analysed in plasma and urine of controls, patients with inflammatory bowel disease (IBD), and patients
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5

Stansen, Corinna, Davin Uy, Stephane Delaunay, Lothar Eggeling, Jean-Louis Goergen, and Volker F. Wendisch. "Characterization of a Corynebacterium glutamicum Lactate Utilization Operon Induced during Temperature-Triggered Glutamate Production." Applied and Environmental Microbiology 71, no. 10 (October 2005): 5920–28. http://dx.doi.org/10.1128/aem.71.10.5920-5928.2005.

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ABSTRACT Gene expression changes of glutamate-producing Corynebacterium glutamicum were identified in transcriptome comparisons by DNA microarray analysis. During glutamate production induced by a temperature shift, C. glutamicum strain 2262 showed significantly higher mRNA levels of the NCgl2816 and NCgl2817 genes than its non-glutamate-producing derivative 2262NP. Reverse transcription-PCR analysis showed that the two genes together constitute an operon. NCgl2816 putatively codes for a lactate permease, while NCgl2817 was demonstrated to encode quinone-dependent l-lactate dehydrogenase, whic
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6

Romanov, Andrey Yurievich, Andrey Mikhailovich Prikhodko, Oleg Vladimirovich Tysyachnyi, Oleg Radomirovich Baev, Ekaterina Lvovna Yarotskaya, and Gennady Tikhonovich Sukhikh. "Comparison of cord blood lactate measurement by gas analyzer and portable electrochemical devices." Journal of Perinatal Medicine 48, no. 2 (February 25, 2020): 157–61. http://dx.doi.org/10.1515/jpm-2019-0357.

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AbstractObjectiveTo compare the accuracy of cord blood lactate measurement using gas analyzer and portable devices in order to assess possibility of implementation of these devices in clinical practice.MethodsWe performed a prospective observational study using 30 umbilical cord samples which were obtained immediately after birth. Portable electrochemical devices Lactate Scout (SensLab GmbH, Leipzig, Germany) and StatStrip Lactate (NOVA Biomedical, Waltham, MA, USA) were used to determine lactate level. A gas analyzer ABL800 FLEX (Radiometer Medical ApS, Brønshøj-Husum, Denmark) was used as a
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7

Wasserman, K., W. L. Beaver, J. A. Davis, J. Z. Pu, D. Heber, and B. J. Whipp. "Lactate, pyruvate, and lactate-to-pyruvate ratio during exercise and recovery." Journal of Applied Physiology 59, no. 3 (September 1, 1985): 935–40. http://dx.doi.org/10.1152/jappl.1985.59.3.935.

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The pattern of lactate increase and its relation to pyruvate and lactate-to-pyruvate (L/P) ratio were studied during exercise and early recovery in 10 normal subjects for incremental exercise on a cycle ergometer. Gas exchange was measured breath by breath. Lactate and pyruvate were measured by enzymatic techniques. Lactate and log lactate changed only slightly at low levels of O2 uptake (VO2) but both began to abruptly increase at approximately 40–55% of the maximal VO2. However, the point of abrupt increase in pyruvate occurred at higher work rates and the rate of increase was not as great a
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8

Georgi, Tobias, Verena Engels, and Volker F. Wendisch. "Regulation of l-Lactate Utilization by the FadR-Type Regulator LldR of Corynebacterium glutamicum." Journal of Bacteriology 190, no. 3 (November 26, 2007): 963–71. http://dx.doi.org/10.1128/jb.01147-07.

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ABSTRACT Corynebacterium glutamicum can grow on l-lactate as a sole carbon and energy source. The NCgl2816-lldD operon encoding a putative transporter (NCgl2816) and a quinone-dependent l-lactate dehydrogenase (LldD) is required for l-lactate utilization. DNA affinity chromatography revealed that the FadR-type regulator LldR (encoded by NCgl2814) binds to the upstream region of NCgl2816-lldD. Overexpression of lldR resulted in strongly reduced NCgl2816-lldD mRNA levels and strongly reduced LldD activity, and as a consequence, a severe growth defect was observed in cells grown on l-lactate as t
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9

Ramirez Ramos, Cristhian Felipe, Clara Inés Saldarriaga-Giraldo, Manuela Yepes-Calderón, Gustavo Adolfo Castilla-Agudelo, Mateo Aránzazu Uribe, Santiago Saldarriaga Betancur, Paulina Casto, et al. "Arterial lactate levels and their prognostic value in patients undergoing pulmonary thromboendarterectomy." Archivos Peruanos de Cardiología y Cirugía Cardiovascular 2, no. 2 (May 27, 2021): 123–29. http://dx.doi.org/10.47487/apcyccv.v2i2.131.

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Objective. Evaluate the change of lactate levels and its prognostic role in the postoperative period of patients undergoing pulmonary thromboendarterectomy. Methods. Retrospective study between 2001 and 2019. Patients older than 18 years and who underwent pulmonary thromboendarterectomy were included. The U Mann Whitney test was performed to evaluate the change between lactate levels, and Cox regression analysis to evaluate the relationship with mortality. Areas under the curve were constructed for lactate levels. Results. Seventy-three patients were operated on during the study period. Median
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10

Felipe, A., X. Remesar, and M. Pastor-Anglada. "l-lactate uptake by rat liver. Effect of food deprivation and substrate availability." Biochemical Journal 273, no. 1 (January 1, 1991): 195–98. http://dx.doi.org/10.1042/bj2730195.

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We have studied the role of substrate availability on net L-lactate uptake by liver of anaesthetized fed and 24 h-fasted rats. L-Lactate was infused through a mesenteric vein at infusion rates equivalent to 0, 0.125, 0.25 and 0.5 times the basal turnover rate (Rt). By these means we were able to increase L-lactate portal concentrations up to 5.5 mM, without significant changes in portal pH. In the basal state (0 Rt), a net L-lactate uptake by liver was found in 24 h-fasted animals. No net balance was observed in fed rats. Infusion of L-lactate in fed animals failed to induce a net hepatic upta
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11

Jenei, Kinga, Ildikó Szatmári, Eszter Szabó, Anjum Mariam, Andrea Luczay, Petra Zsidegh, and Péter Tóth-Heyn. "Laktátszintváltozások diabeteses ketoacidosisban és frissen diagnosztizált 1-es típusú diabetes mellitusban." Orvosi Hetilap 160, no. 45 (November 2019): 1784–90. http://dx.doi.org/10.1556/650.2019.31533.

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Abstract: Introduction: It is known that lactate concentration is increased in diabetic ketoacidosis (DKA), however, the pathophysiology and kinetics of lactate changes are still unclear. Normally, L-lactate is the major form in the human body. According to previous data, also D- and L-lactate might be increased in hyperglycaemic disorders. Aim: We aimed to describe the kinetics and mechanisms of lactate concentration changes in ketoacidosis and newly diagnosed diabetes. Method: We performed a prospective study, including 5–18-year-old children with ketoacidosis (DKA, n = 13) and with newly di
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12

Pehnyo, N. V. "The practical significance of lactate levels in fetal blood at his urgent condition." HEALTH OF WOMAN, no. 1(117) (February 28, 2017): 120–22. http://dx.doi.org/10.15574/hw.2017.117.120.

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The objective: to establish whether the level of lactate in the blood of the fetus to be reliable criterion of his suffering and indication for changing tactics of childbirth. Patients and methods. The study included 511 pregnant women. Criteria for inclusion in the study: full-term births with singleton pregnancy, cephalic presentation fetus, the absence of membranes, opening the cervix 3 cm or more, according KTG questionable fetus. Included in the study are pregnant randomized into 2 groups. In the study group included 253 women in childbirth, in which the fetus at CTG rated as doubtful and
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13

Merkle-Storms, Julia, Ilija Djordjevic, Carolyn Weber, Soi Avgeridou, Ihor Krasivskyi, Christopher Gaisendrees, Navid Mader, et al. "Impact of Lactate Clearance on Early Outcomes in Pediatric ECMO Patients." Medicina 57, no. 3 (March 18, 2021): 284. http://dx.doi.org/10.3390/medicina57030284.

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Background and Objectives: Pediatric extracorporeal membrane oxygenation (ECMO) support is often the ultimate therapy for neonatal and pediatric patients with congenital heart defects after cardiac surgery. The impact of lactate clearance in pediatric patients during ECMO therapy on outcomes has been analyzed. Materials andMethods: We retrospectively analyzed data from 41 pediatric vaECMO patients between January 2006 and December 2016. Blood lactate and lactate clearance have been recorded prior to ECMO implantation and 3, 6, 9 and 12 h after ECMO start. Receiver operating characteristic (ROC
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14

Doğan, NÖ, A. Savrun, S. Levent, GP Günaydın, GK Çelik, H. Akküçük, and Y. Çevik. "Can initial lactate levels predict the severity of unintentional carbon monoxide poisoning?" Human & Experimental Toxicology 34, no. 3 (June 27, 2014): 324–29. http://dx.doi.org/10.1177/0960327114538986.

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Introduction: Accidental carbon monoxide (CO) intoxication is a major cause of unintentional poisoning. This study aimed to determine the value of initial lactate levels in patients with CO poisoning and to evaluate its utilization in the emergency department (ED). Methods: A retrospective cross-sectional study was carried out among patients with CO intoxication, who were admitted to the ED between April 1, 2011 and April 1, 2012. The study data were extracted from a hospital database system using International Classification of Diseases-10 diagnosis codes. The patients were analyzed according
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15

Rana, Faraz Ali, Helen Mary Robert, Madiha Ilyas, Asad Mahmood, Muhammad Amir, and Nabeela Khan. "DIAGNOSTIC UTILITY OF SERUM LACTATE DEHYDROGENASE LEVELS (LDL) IN DIFFERENTIATING MEGALOBLASTIC ANEMIA FROM MYELODYSPLASTIC SYNDROMES IN PAKISTAN." PAFMJ 71, no. 5 (October 30, 2021): 1539–43. http://dx.doi.org/10.51253/pafmj.v71i5.5003.

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Objective: To study the diagnostic utility of lactate dehydrogenase levels in differentiating megaloblastic anemia from myelodysplastic anemia in Pakistan.
 Study Design: Comparative cross-sectional study.
 Place and Duration of Study: Department of Hematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan from Feb, 2019 to Aug, 2019.
 Methodology: In this study, total 240 patients (18-75 years of age) males and females were selected by consecutive sampling technique and were equally divided into 3 groups; patients with megaloblastic anemia, patients with myelodyspla
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16

Mosienko, Valentina, Anja G. Teschemacher, and Sergey Kasparov. "Is L-Lactate a Novel Signaling Molecule in the Brain?" Journal of Cerebral Blood Flow & Metabolism 35, no. 7 (April 29, 2015): 1069–75. http://dx.doi.org/10.1038/jcbfm.2015.77.

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In the brain, L-lactate is produced by both neurons and astrocytes. There is no doubt that neurons use L-lactate as a supplementary fuel although the importance of this energy source is disputed. Irrespective of its caloric value, L-lactate might also have a signaling role in the brain. Here, we review several current hypotheses of L-lactate mediated signaling. Some proposed mechanisms require L-lactate entry into the neurons leading to a shift in ATP/ADP ratio or redox state. Others postulate interaction with either known receptor HCA1 (GPR81) or a novel, yet unidentified receptor. We argue t
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17

Santos, Renato X., Valeria Melis, Elizabeth A. Goatman, Michael Leith, Thomas C. Baddeley, John M. D. Storey, Gernot Riedel, Claude M. Wischik, and Charles R. Harrington. "HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine." Biomedicines 10, no. 4 (April 7, 2022): 867. http://dx.doi.org/10.3390/biomedicines10040867.

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The tau protein aggregation inhibitor hydromethylthionine mesylate (HMTM) was shown recently to have concentration-dependent pharmacological activity in delaying cognitive decline and brain atrophy in phase 3 Alzheimer’s disease (AD) clinical trials; the activity was reduced in patients receiving symptomatic therapies. The methylthionine (MT) moiety has been reported to increase the clearance of pathological tau and to enhance mitochondrial activity, which is impaired in AD patients. In line 1 (L1) mice (a model of AD), HMTM (5/15 mg/kg) was administered either as a monotherapy or as an add-on
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Severson, Kristen A., Laura Ritter-Cox, Jesse D. Raffa, Leo Anthony Celi, and William J. Gordon. "Vasopressin Administration Is Associated With Rising Serum Lactate Levels in Patients With Sepsis." Journal of Intensive Care Medicine 35, no. 9 (August 21, 2018): 881–88. http://dx.doi.org/10.1177/0885066618794925.

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Background:Vasopressin is used in conjunction with norepinephrine during treatment of patients with septic shock. Serum lactate is often used in monitoring of patients with sepsis; however, its importance as a therapeutic target is unclear. The objective of this study is to examine the relationship of vasopressin use on serum lactate levels in patients with sepsis.Methods:This study uses electronic heath records available via the Medical Information Mart for Intensive Care III. Patients were required to have a serum lactate monitoring during the intensive care unit (ICU) stay. The treatment wa
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Stevenson, R. W., D. R. Mitchell, G. K. Hendrick, R. Rainey, A. D. Cherrington, and R. T. Frizzell. "Lactate as substrate for glycogen resynthesis after exercise." Journal of Applied Physiology 62, no. 6 (June 1, 1987): 2237–40. http://dx.doi.org/10.1152/jappl.1987.62.6.2237.

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Muscle glycogen levels in the perfused rat hemicorpus preparation were reduced two-thirds by electrical stimulation plus exposure to epinephrine (10(-7) M) for 30 min. During the contraction period muscle lactate concentrations increased from a control level of 3.6 +/- 0.6 to a final value of 24.1 +/- 1.6 mumol/g muscle. To determine whether the lactate that had accumulated in muscle during contraction could be used to resynthesize glycogen, glycogen levels were determined after 1–3 h of recovery from the contraction period during which time the perfusion medium (flow-through system) contained
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Veličković, Jelena, Ivan Palibrk, Biljana Miličić, Dejan Veličković, Bojan Jovanović, Goran Rakić, Milorad Petrović, and Vesna Bumbaširević. "The association of early postoperative lactate levels with morbidity after elective major abdominal surgery." Bosnian Journal of Basic Medical Sciences 19, no. 1 (February 12, 2019): 72–80. http://dx.doi.org/10.17305/bjbms.2018.3186.

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Lactate levels are widely used as an indicator of outcome in critically ill patients. We investigated the prognostic value of postoperative lactate levels for postoperative complications (POCs), mortality and length of hospital stay after elective major abdominal surgery. A total of 195 patients were prospectively evaluated. Lactate levels were assessed on admission to the intensive care unit (ICU) [L0], at 4 hours (L4), 12 hours (L12), and 24 hours (L24) after the operation. Demographic and perioperative clinical data were collected. Patients were monitored for complications until discharge o
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Chen, Fu-Cheng, Chia-Te Kung, Hsien-Hung Cheng, Chi-Yung Cheng, Tsung-Cheng Tsai, Sheng-Yuan Hsiao, Chien-Hung Wu, and Chih-Min Su. "Metformin Affects Serum Lactate Levels in Predicting Mortality of Patients with Sepsis and Bacteremia." Journal of Clinical Medicine 8, no. 3 (March 6, 2019): 318. http://dx.doi.org/10.3390/jcm8030318.

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This study determined if the use of metformin affected the prognostic value of hyperlactatemia in predicting 28-day mortality among patients with sepsis and bacteremia. We enrolled adult diabetic patients with sepsis and bacteremia. Of 590 patients, 162 and 162 metformin users and nonusers, respectively, were selected in propensity matching. The mean serum lactate levels in metformin users were higher than those in nonusers (4.7 vs. 3.9 mmol/L, p = 0.044). We divided the patients into four groups based on quick Sepsis-related Organ Failure Assessment (qSOFA) scores. No significant difference w
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22

Jon Van Tienhoven, Arne, Cornelis AJ Van Beers, Carl EH Siegert, and Prabath WB Nanayakkara. "The utility of peripheral venous lactate in emergency department patients with normal and higher lactate levels: A prospective observational study." Acute Medicine Journal 19, no. 3 (July 1, 2020): 125–30. http://dx.doi.org/10.52964/amja.0815.

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Objective: to assess the utility of peripheral venous lactate (PVL) in Emergency Department patients. Methods: arteriovenous agreement was assessed in three subgroups: PVL <2 mmol/l, PVL ≥ 2 mmol/l to < 4 mmol/l and PVL ≥ 4 mmol/l. The predictive value of PVL to predict arterial lactate (AL) ≥2 mmol/l was assessed at different cut-off values. Results: 74 samples were analysed. The venous-arterial mean difference and 95% limits of agreement for the subgroups were 0.25 mmol/l (-0.18 to 0.68), 0.37 mmol/l (-0.57 to 1.32) and -0.89 mmol/l (-3.75 to 1.97). PVL ≥2 mmol/l predicts AL ≥2 mmol/l
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Xu, Xianzhi, Rong Xu, Shuang Hou, Zhaoqi Kang, Chuanjuan Lü, Qian Wang, Wen Zhang, et al. "A Selective Fluorescent l-Lactate Biosensor Based on an l-Lactate-Specific Transcription Regulator and Förster Resonance Energy Transfer." Biosensors 12, no. 12 (December 1, 2022): 1111. http://dx.doi.org/10.3390/bios12121111.

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Selective detection of l-lactate levels in foods, clinical, and bacterial fermentation samples has drawn intensive attention. Many fluorescent biosensors based on non-stereoselective recognition elements have been developed for lactate detection. Herein, the allosteric transcription factor STLldR from Salmonella enterica serovar Typhimurium LT2 was identified to be stereo-selectively respond to l-lactate. Then, STLldR was combined with Förster resonance energy transfer (FRET) to construct a fluorescent l-lactate biosensor FILLac. FILLac was further optimized by truncating the N- and C-terminal
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Cooker, Laurinda A., Patricia Luneburg, Clifford J. Holmes, Suzanne Jones, Nicholas Topley, D. O'Donoghue, L. Frenken, et al. "Interleukin-6 Levels Decrease in Effluent from Patients Dialyzed with Bicarbonate/Lactate–Based Peritoneal Dialysis Solutions." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 21, no. 3_suppl (December 2001): 102–7. http://dx.doi.org/10.1177/089686080102103s17.

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♦ Objective Conventional lactate-buffered peritoneal dialysis (PD) solutions have several bioincompatible characteristics, including acidic pH, lactate buffer, and the presence of glucose degradation products (GDPs). These characteristics, along with inflammation, are believed to contribute to membrane dysfunction in peritoneal dialysis patients. A new PD solution containing a bicarbonate/ lactate buffer system with physiologic pH and low GDPs has shown improved biocompatibility in both in vitro and ex vivo studies. In the present study, the concentrations of cytokines interleukin-6 (IL-6), tu
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Otte, Kjeld, Maria Theresa Gonzalez, Maria-Auxiliadora Bajo, Gloria Del Peso, James Heaf, Gorka Garcia Erauzkin, Jose A. Sanchez Tomero, et al. "Clinical Experience with a New Bicarbonate (25 Mmol/L)/Lactate (10 Mmol/L) Peritoneal Dialysis Solution." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 23, no. 2 (March 2003): 138–45. http://dx.doi.org/10.1177/089686080302300208.

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Objective Physiological bicarbonate/lactate-based solutions may correct acidosis in a better way than standard lactate-based solutions. In this study, a new 25 mmol/L bicarbonate/10 mmol/L lactate peritoneal dialysis (PD) solution was compared with a standard 35 mmol/L lactate solution. Design This was a prospective open label study. All patients had a 2-week baseline period using the standard lactate solution, followed by 8 weeks on the bicarbonate/lactate solution and 2 weeks on the lactate-basedsolution. Setting Four Danish and four Spanish nephrology centers. Patients 40 well-dialyzed (cre
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Iskandar, Agustin, Nada Putri Pranidya, Eko Sulistijono, and Aryati Aryati. "Correlation Between Lactic Acid Concentration and The Severity of Neonatal Sepsis." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 26, no. 1 (November 22, 2019): 55. http://dx.doi.org/10.24293/ijcpml.v26i1.1370.

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BackgroundsNeonatal sepsis remains a major cause of high infant mortality rate in Indonesia, and served as one of risk factor for early neonatal mortality. This study aims to determine the relationship between lactate levels andthe severity of sepsis and prognostic value of lactic acid as a predictor of severity in neonatal sepsis.. MethodsThis research is analytic observational research using cross sectional method. The subjects were patients of neonatal sepsis treated in the Perinatology Room of Saiful Anwar Hospital Malang from February to June 2015. Lactic acid concentration in plasma was
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Charlton, Karl, and Hayley Stagg. "Prognostic value of lactate in out-of-hospital cardiac arrest: a prospective cohort study." Journal of Paramedic Practice 14, no. 4 (April 2, 2022): 138–45. http://dx.doi.org/10.12968/jpar.2022.14.4.138.

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Background: The prognostic role of lactate in out-of-hospital cardiac arrest (OHCA) remains unclear. Aims: To explore serum lactate as a predictor of return of spontaneous circulation in patients experiencing OHCA after arrival at hospital. Methods: This 13-month prospective observational cohort study involved patients aged ≥18 years. Serum lactate levels were measured during cardiopulmonary resuscitation before ROSC. Patients were divided into two groups by lactate level: Group 1, low (≤9.9 mmol/l) and Group 2, high (≥10 mmol/l). Findings: 105 patients were included, 50 in group 1 and 55 grou
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Hsu, Shu-Hsien, Po-Hsuan Kao, Tsung-Chien Lu, Chih-Hung Wang, Cheng-Chung Fang, Wei-Tien Chang, Chien-Hua Huang, and Chu-Lin Tsai. "Serum Lactate for Predicting Cardiac Arrest in the Emergency Department." Journal of Clinical Medicine 11, no. 2 (January 13, 2022): 403. http://dx.doi.org/10.3390/jcm11020403.

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Objectives: Early recognition and prevention of in-hospital cardiac arrest (IHCA) play an increasingly important role in the Chain of Survival. However, clinical tools for predicting IHCA in the emergency department (ED) are scanty. We sought to evaluate the role of serum lactate in predicting ED-based IHCA. Methods: Data were retrieved from 733,398 ED visits over a 7-year period in a tertiary medical centre. We selected one ED visit per person and excluded out-of-hospital cardiac arrest, children, or those without lactate measurements. Patient demographics, computerised triage information, an
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Mazza, Juan C., Raúl L. Festa, Sandra L. Prieto, Patricia Cosolito, and Alvaro N. Gurovich. "Lactate Threshold Velocity At 4 mMol/l Does Not Maintain Blood Lactate Levels During Steady State Intensity." Medicine & Science in Sports & Exercise 51, Supplement (June 2019): 325. http://dx.doi.org/10.1249/01.mss.0000561484.04890.33.

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Park, Ik Hyun, Hyun Kyu Cho, Ju Hyeon Oh, Woo Jung Chun, Yong Hwan Park, Mirae Lee, Min Sun Kim, et al. "Clinical Significance of Serum Lactate in Acute Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study." Journal of Clinical Medicine 10, no. 22 (November 13, 2021): 5278. http://dx.doi.org/10.3390/jcm10225278.

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Little is known about causality and the pathological mechanism underlying the association of serum lactate with myocardial injury in patients with acute myocardial infarction (AMI). We evaluated data from 360 AMI patients undergoing percutaneous coronary intervention (PCI) using cardiovascular magnetic resonance imaging (CMR). Of these, 119 patients had serum lactate levels > 2.5 mmol/L on admission (high serum lactate group), whereas 241 patients had serum lactate levels ≤ 2.5 mmol/L (low serum lactate group). We compared the myocardial infarct size assessed by CMR between the two groups a
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Pan, Jullie W., Douglas L. Rothman, Kevin L. Behar, Daniel T. Stein та Hoby P. Hetherington. "Human Brain β-Hydroxybutyrate and Lactate Increase in Fasting-Induced Ketosis". Journal of Cerebral Blood Flow & Metabolism 20, № 10 (жовтень 2000): 1502–7. http://dx.doi.org/10.1097/00004647-200010000-00012.

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Ketones are known to constitute an important fraction of fuel for consumption by the brain, with brain ketone content generally thought to be low. However, the recent observation of 1-mmol/L levels of brain β-hydroxybutyrate (BHB) in children on the ketogenic diet suggests otherwise. The authors report the measurement of brain BHB and lactate in the occipital lobe of healthy adults using high field (4-T) magnetic resonance spectroscopy, measured in the nonfasted state and after 2-and 3-day fasting-induced ketosis. A 9-mL voxel located in the calcarine fissure was studied, detecting the BHB and
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Carrard, A., M. Elsayed, M. Margineanu, B. Boury-Jamot, L. Fragnière, E. M. Meylan, J.-M. Petit, H. Fiumelli, P. J. Magistretti, and J.-L. Martin. "Peripheral administration of lactate produces antidepressant-like effects." Molecular Psychiatry 23, no. 2 (October 18, 2016): 392–99. http://dx.doi.org/10.1038/mp.2016.179.

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Abstract In addition to its role as metabolic substrate that can sustain neuronal function and viability, emerging evidence supports a role for l-lactate as an intercellular signaling molecule involved in synaptic plasticity. Clinical and basic research studies have shown that major depression and chronic stress are associated with alterations in structural and functional plasticity. These findings led us to investigate the role of l-lactate as a potential novel antidepressant. Here we show that peripheral administration of l-lactate produces antidepressant-like effects in different animal mod
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Morris, David M., Rebecca S. Shafer, Kimberly R. Fairbrother, and Mark W. Woodall. "Effects of Lactate Consumption on Blood Bicarbonate Levels and Performance During High-Intensity Exercise." International Journal of Sport Nutrition and Exercise Metabolism 21, no. 4 (August 2011): 311–17. http://dx.doi.org/10.1123/ijsnem.21.4.311.

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The authors sought to determine the effects of oral lactate consumption on blood bicarbonate (HCO3−) levels, pH levels, and performance during high-intensity exercise on a cycle ergometer. Subjects (N = 11) were trained male and female cyclists. Time to exhaustion (TTE) and total work were measured during high-intensity exercise bouts 80 min after the consumption of 120 mg/kg body mass of lactate (L), an equal volume of placebo (PL), or no treatment (NT). Blood HCO3− increased significantly after ingestion of lactate (p < .05) but was not affected in PL or NT (p > .05). No changes in pH
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Wiegers, Evita C., Hanne M. Rooijackers, Cees J. Tack, Bart WJ Philips, Arend Heerschap, Marinette van der Graaf, and Bastiaan E. de Galan. "Effect of lactate administration on brain lactate levels during hypoglycemia in patients with type 1 diabetes." Journal of Cerebral Blood Flow & Metabolism 39, no. 10 (May 11, 2018): 1974–82. http://dx.doi.org/10.1177/0271678x18775884.

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Administration of lactate during hypoglycemia suppresses symptoms and counterregulatory responses, as seen in patients with type 1 diabetes and impaired awareness of hypoglycemia (IAH), presumably because lactate can substitute for glucose as a brain fuel. Here, we examined whether lactate administration, in a dose sufficient to impair awareness of hypoglycemia, affects brain lactate levels in patients with normal awareness of hypoglycemia (NAH). Patients with NAH ( n = 6) underwent two euglycemic-hypoglycemic clamps (2.8 mmol/L), once with sodium lactate infusion (NAH w|lac) and once with sal
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Andrews, M. A., R. E. Godt, and T. M. Nosek. "Influence of physiological L(+)-lactate concentrations on contractility of skinned striated muscle fibers of rabbit." Journal of Applied Physiology 80, no. 6 (June 1, 1996): 2060–65. http://dx.doi.org/10.1152/jappl.1996.80.6.2060.

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These experiments investigated the effects of physiological concentrations of L(+)-lactate on the contractility of chemically skinned rabbit fast-twitch psoas, slow-twitch soleus, and cardiac muscles at pH 7.L(+)-Lactate depressed maximal calcium-activated force (Fmax) of all muscles studied within the range of 5-20 (slow-twitch muscle) or 5-25 mM (fast-twitch and cardiac muscles). Fmax of fast-twitch fibers was inhibited to the greatest degree (9% in K2 creatine phosphate solutions). In all of these muscle types, Fmax returned to control levels as L(+)-lactate was increased to 30-50 mM. Subst
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Chen, Xue, Jianbin Bi, Jia Zhang, Zhaoqing Du, Yifan Ren, Shasha Wei, Fenggang Ren, Zheng Wu, Yi Lv, and Rongqian Wu. "The Impact of Serum Glucose on the Predictive Value of Serum Lactate for Hospital Mortality in Critically Ill Surgical Patients." Disease Markers 2019 (November 26, 2019): 1–10. http://dx.doi.org/10.1155/2019/1578502.

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Background. Lactate has been widely used as a risk indicator of outcomes in critically ill patients due to its ready measurement and good predictive ability. However, the interconnections between lactate metabolism and glucose metabolism have not been sufficiently explored, yet. In this study, we aimed to investigate whether glucose levels could influence the predictive ability of lactate and design a more comprehensive strategy to assess the in-hospital mortality of critically ill patients. Methods. We analyzed the clinical data of 293 critically ill patients. The primary outcome was in-hospi
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Duval, Benoit, Thibaud Besnard, Stefano Mion, Sébastien Leuillet, Olivier Jecker, Louis Labrousse, Alain Rémy, Cedrick Zaouter, and Alexandre Ouattara. "Intraoperative changes in blood lactate levels are associated with worse short-term outcomes after cardiac surgery with cardiopulmonary bypass." Perfusion 34, no. 8 (June 28, 2019): 640–50. http://dx.doi.org/10.1177/0267659119855857.

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Background: A high perioperative blood lactate level has been reported to be associated with poor outcomes after cardiac surgery. More than isolated peaks of lactate values, it should be more interesting to take into account changes in intraoperative blood lactate level (∆Lact). This large-scale retrospective study evaluated the relationship between ∆Lact and overall intensive care unit morbidity and 30-day all-cause mortality. Methods: Perioperative data from consecutive patients undergoing on-pump cardiac surgery between September 2010 and June 2016 were retrospectively analysed through our
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38

GLEESON, TODD T., and PAULA M. DALESSIO. "Lactate and Glycogen Metabolism in the Lizard Dipsosaurus Dorsalis following Exhaustive Exercise." Journal of Experimental Biology 144, no. 1 (July 1, 1989): 377–93. http://dx.doi.org/10.1242/jeb.144.1.377.

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We evaluated the metabolic mechanisms by which the iguanid lizard Dipsosaurus dorsalis deals with the lactate which accumulates during vigorous exercise. Fasted, cannulated lizards were run for 5 min on a treadmill at 40°C, which elevated whole-body lactate to 24 mmol l−1 and depleted hindlimb glycogen to 70% of resting levels. Oxygen consumption increased fivefold and respiratory exchange ratios approached 2.0. Exhausted animals were then injected intravenously with either [U-14C]lactate or [U-14C]glucose, and allowed to recover quietly on the treadmill at 40°C. After 2h, 79% of the accumulat
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Coles, Gerald A., Ram Gokal, Chisholm Ogg, Fiona Jani, Donal T. O'Donoghue, Giovanni C. Cancarinu, Rosario Maiorca, Anders Tranaeus, Dirk Faict, and Catherine De Vos. "A Randomized Controlled Trial of a Bicarbonate and a Bicarbonate/Lactate-Containing Dialysis Solution in Capd." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 17, no. 1 (January 1997): 48–51. http://dx.doi.org/10.1177/089686089701700111.

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Objective To evaluate the safety and efficacy of bicarbonate and bicarbonate/lactate-based PD fluids. Design A randomly allocated prospective controlled trial lasting eight weeks. Setting Five renal units in Europe. Patients Individuals who have been treated by CAPD for at least three months and who have had at least one month's therapy with 40 mmol/L lactate PD fluid. Those with recent infection, diabetes or other serious illness are excluded. Forty-seven individuals have entered the study so far. Interventions Patients are randomly allocated to three groups. Group 1 receive 40 mmol/L lactate
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Shields, Beth A., Kaitlin A. Pruskowski, Alicia M. Williams, and Leopoldo C. Cancio. "708 Enteral Nutrition Initiation During Periods of Vasopressor Requirements and Elevated Lactate Levels." Journal of Burn Care & Research 41, Supplement_1 (March 2020): S185—S186. http://dx.doi.org/10.1093/jbcr/iraa024.294.

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Abstract Introduction Nutrition is a core component of care for the critically ill burn patient. The Society for Critical Care Medicine recommends initiating enteral nutrition (EN) within 4–6 hours of injury for burn patients, while simultaneously recommending waiting until hemodynamic stability is achieved for critical care patients. The goal of this analysis was to evaluate tolerance of EN during periods of different pressor requirements and lactate levels. Methods We performed a retrospective evaluation on all burn patients admitted to our intensive care unit in 2018 who received EN. This p
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Kost, Gerald J., Tam H. Nguyen, and Zuping Tang. "Whole-Blood Glucose and Lactate." Archives of Pathology & Laboratory Medicine 124, no. 8 (August 1, 2000): 1128–34. http://dx.doi.org/10.5858/2000-124-1128-wbgal.

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Abstract Objective.—To assess the effects of 30 of the most commonly used critical care drugs on measurements obtained with trilayer electrochemical biosensors on a reference analyzer (ABL625-GL), to determine metabolic changes in glucose and lactate in vitro, and to formulate guidelines for whole-blood analysis of these 2 analytes. Design.—Serial measurements were taken of changes in glucose and lactate levels caused by metabolism in whole blood in vitro over time. A parallel control study of drug interference with measurements of glucose and lactate in whole blood and of dose-response relati
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GLASS, KATHLEEN A., DAWN A. GRANBERG, ANGELIQUE L. SMITH, ANN MARIE McNAMARA, MARGARET HARDIN, JANE MATTIAS, KEVIN LADWIG, and ERIC A. JOHNSON. "Inhibition of Listeria monocytogenes by Sodium Diacetate and Sodium Lactate on Wieners and Cooked Bratwurst." Journal of Food Protection 65, no. 1 (January 1, 2002): 116–23. http://dx.doi.org/10.4315/0362-028x-65.1.116.

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The inhibition of Listeria monocytogenes by sodium lactate and sodium diacetate was evaluated for wieners containing pork, turkey, and beef and for cooked bratwurst containing beef and pork. Both products were supplied by commercial manufacturers. Treated products were surface-inoculated with 105 CFU of L. monocytogenes per package and vacuum-packed in gas-impermeable pouches. Wieners were stored for 60 days at 4.5°C, and bratwurst were stored for 84 days at 3 and 7°C. A surface treatment that consisted of dipping wieners into solutions containing ≤6% lactate and ≤3% diacetate for 5 s did not
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Thapa, Mukesh, Ryong Sung, and Yun Seok Heo. "A Dual Electrode Biosensor for Glucose and Lactate Measurement in Normal and Prolonged Obese Mice Using Single Drop of Whole Blood." Biosensors 11, no. 12 (December 9, 2021): 507. http://dx.doi.org/10.3390/bios11120507.

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Understanding the levels of glucose (G) and lactate (L) in blood can help us regulate various chronic health conditions such as obesity. In this paper, we introduced an enzyme-based electrochemical biosensor adopting glucose oxidase and lactate oxidase on two working screen-printed carbon electrodes (SPCEs) to sequentially determine glucose and lactate concentrations in a single drop (~30 µL) of whole blood. We developed a diet-induced obesity (DIO) mouse model for 28 weeks and monitored the changes in blood glucose and lactate levels. A linear calibration curve for glucose and lactate concent
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Erum, Uzma, Tahira Perveen Umer, Shafiq-ur Rehman Arain, Muhammad Rashid Ahmed, and Lubna Nazir. "Significance of Elevated Synovial Fluid Lactic Acid and Lactate Dehydrogenase Levels in Differentiating Between Septic Arthritis, Inflammatory Arthritis and Non-Inflammatory Arthritis." Pakistan Armed Forces Medical Journal 72, SUPPL-2 (June 6, 2022): S276–79. http://dx.doi.org/10.51253/pafmj.v72isuppl-2.4369.

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Objective: To determine the lactic acid and lactate dehydrogenase levels in synovial fluid and differentiate between inflammatory and non-inflammatory arthritis.
 Study Design: Cross-sectional study.
 Place and Duration of Study: Department of Rheumatology, Liaquat National Hospital, Karachi, from Feb to May 2019.
 Methodology: All patients of age >18 years, of either gender, who presented with knee joint effusion were enrolled in the study. Synovial fluid aspiration for the analysis of lactate and lactate dehydrogenase (LDH) was done for all patients.
 Results: Seventy-
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Lv, Xuemei, Qian Ren, Lingli Zhou, Yanyan Geng, Jia Song, A. Mina, Basang Puchi, Senlin Yang, Shuyou Meng, and Lihui Yang. "Safety of Metformin Therapy in Patients with Type 2 Diabetes Living on an Oxygen-Deficient Plateau, Tibet, China." Experimental and Clinical Endocrinology & Diabetes 126, no. 07 (November 8, 2017): 460–64. http://dx.doi.org/10.1055/s-0043-113830.

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Abstract Background In the general population, the absolute risk of lactic acidosis in patients treated with metformin appears to be low. However, in the Tibetan plateau, an extreme oxygen-deficient environment, there are no data available concerning the safety of metformin. The aim of our study is to assess the safety of metformin in people of the plateau area. Methods We conducted an observational cross-sectional study in Tibet. All the 166 subjects were divided into two groups: T2DM+metformin group and T2DM group. Clinical characteristics as well as lactate levels were measured in all subje
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Chebl, Ralphe Bou, Hani Tamim, Gilbert Abou Dagher, Musharaf Sadat, Farhan Al Enezi, and Yaseen M. Arabi. "Serum Lactate as an Independent Predictor of In-Hospital Mortality in Intensive Care Patients." Journal of Intensive Care Medicine 35, no. 11 (June 9, 2019): 1257–64. http://dx.doi.org/10.1177/0885066619854355.

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Purpose: The aim of this study was to check if serum lactate was independently associated with mortality among critically ill patients. Materials and Methods: This was a single-center, retrospective cohort study. All adult patients (>18 years of age) who had at least 1 measurement of lactate within 24 hours of admission to intensive care unit (ICU) between January 2002 and December 2017 were included in the analysis. Patients were stratified into 3 groups: those with a serum lactate of <2 mmol/L (normal level), 2 to 4 mmol/L (intermediate level), and >4 mmol/L (high level). The primar
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Murtuza, F., AJ Farrier, M. Venkatesan, R. Smith, A. Khan, CE Uzoigwe, and G. Chami. "Is there an association between body temperature and serum lactate levels in hip fracture patients?" Annals of The Royal College of Surgeons of England 97, no. 7 (October 1, 2015): 513–18. http://dx.doi.org/10.1308/rcsann.2015.0012.

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Introduction Hyperlactataemia is associated with adverse outcomes in trauma cases. It is thought to be the result of anaerobic respiration during hypoperfusion. This produces much less energy than complete aerobic glycolysis. Low body temperature in the injured patient carries an equally poor prognosis. Significant amounts of energy are expended in maintaining euthermia. Consequently, there may be a link between lactate levels and dysthermia. Hyperlactataemia may be indicative of inefficient energy production and therefore insufficient energy to maintain euthermia. Alternatively, significant a
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Nolph, Karl D., Zbylut J. Twardowski, Ramesh Khanna, Barbara F. Prowant, Leonor P. Ponferrada, Lois M. Schmidt, and Harold L. Moore. "Tidal Peritoneal Dialysis with Racemic or L-Lactate Solutions." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 10, no. 2 (April 1990): 161–64. http://dx.doi.org/10.1177/089686089001000208.

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To see if rapid lactate absorption on tidal peritoneal dialysis (TPD) would overwhelm D-Iactate metabolism using racemic lactate andlor L-Iactate metabolism using all L-Iactate, five patients underwent a- h TPD treatments with racemic lactate solution one day and with L-Iactate another. Lactate concentrations (total) were 40 mmolelL, flow rates 27.3 LIB h, tidal and reservoir volumes each 1.5L, tidal cycles 24–26 min, and net ultrafiltration per tidal cycle 70 to 99 mL. Results: Mean absorptions of D and L-Iactate were 24.2 and 25.1%, respectively, compared to glucose at 14.6%. Urea clearances
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Kerslake, Rachel, Suzana Panfilov, Nashrah Mustafa, Marcia Hall, Ioannis Kyrou, Harpal Randeva, Emmanouil Karteris, and Richard Godfrey. "Elevated Circulating Lactate Levels and Widespread Expression of Its Cognate Receptor, Hydroxycarboxylic Acid Receptor 1 (HCAR1), in Ovarian Cancer." Journal of Clinical Medicine 12, no. 1 (December 27, 2022): 217. http://dx.doi.org/10.3390/jcm12010217.

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Background: Augmented glycolysis in cancer cells is a process required for growth and development. The Warburg effect provides evidence of increased glycolysis and lactic acid fermentation in cancer cells. The lactate end-product of glycolysis is receiving growing traction for its role as a cell signalling molecule. Ovarian cancer (OvCa) is also characterised by altered glucose metabolism. We aim to explore circulating lactate levels in patients with high-grade serous OvCa (HGSOC) and to elucidate the expression of the lactate receptor hydroxycarboxylic acid receptor 1 (HCAR1) in OvCa. Methods
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Ząbczyk, Michał, Joanna Natorska, Agnieszka Janion-Sadowska, Krzysztof P. Malinowski, Marianna Janion, and Anetta Undas. "Elevated Lactate Levels in Acute Pulmonary Embolism Are Associated with Prothrombotic Fibrin Clot Properties: Contribution of NETs Formation." Journal of Clinical Medicine 9, no. 4 (March 30, 2020): 953. http://dx.doi.org/10.3390/jcm9040953.

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Background: Elevated plasma lactate levels correlate with high mortality rate in acute pulmonary embolism (PE) patients. We hypothesized that elevated lactate levels correlate with prothrombotic fibrin clot properties and enhanced neutrophil extracellular trap (NET) formation in acute PE. Methods: As many as 126 normotensive acute PE patients (aged 58 ± 14 years) were enrolled. Plasma fibrin clot permeability (Ks), clot lysis time (CLT), endogenous thrombin potential (ETP), citrullinated histone H3 (citH3), and plasminogen activator inhibitor-1 antigen (PAI-1), together with plasma L-lactate l
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