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1

Geirola, Gustavo, and Adolfo Aristarain. "Martín (Hache)." Chasqui 28, no. 2 (1999): 162. http://dx.doi.org/10.2307/29741553.

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2

Berger, Anne-Emmanuelle. "L'amour sans hache." Littérature 134, no. 2 (2004): 49–63. http://dx.doi.org/10.3406/litt.2004.1848.

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Albera, François. "Toucher la hache !" 1895, no. 52 (September 1, 2007): 153–58. http://dx.doi.org/10.4000/1895.4193.

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Fournier, Dominique. "Plaidoyer pour une hache." Annales de Normandie 48, no. 1 (1998): 23–32. http://dx.doi.org/10.3406/annor.1998.4827.

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King, Adele, and Alain Fleischer. "La Hache et le violon." World Literature Today 79, no. 2 (2005): 92. http://dx.doi.org/10.2307/40158719.

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Adda, Jacques. "Royaume-Uni : à la hache !" Alternatives Économiques N°297, no. 12 (2010): 70. http://dx.doi.org/10.3917/ae.297.0070.

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Cadiot, Pierre. "A la hache ou avec la hache ? Représentation mentale, expérience située et donation du réfèrent." Langue française 91, no. 1 (1991): 7–23. http://dx.doi.org/10.3406/lfr.1991.6202.

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8

Stoewer, Nora, and Georg Kranefoed. "Beispielhafter Wandel eines Baches - die Hache." Wasser und Abfall 21, no. 5 (2019): 53–58. http://dx.doi.org/10.1007/s35152-019-0044-9.

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9

Pernot, Patrice. "Metz (Moselle). 3, rue de la Hache." Archéologie médiévale, no. 46 (December 1, 2016): 184. http://dx.doi.org/10.4000/archeomed.7207.

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10

Poupard, M., S. Chevillard, J. Santrot, and G. Saindrenan. "Étude métallurgique d'une hache à douille armoricaine." Revue de Métallurgie 90, no. 2 (1993): 235–44. http://dx.doi.org/10.1051/metal/199390020235.

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11

Grimal, Jean, and François Branabot. "Une longue hache alpine à Vias (Hérault)." Bulletin de la Société préhistorique française 107, no. 1 (2010): 147–48. http://dx.doi.org/10.3406/bspf.2010.13917.

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12

Zimmermann, Michel. "Christiane Raynaud, « À la hache ! » Histoire et symbolique de la hache dans la France médiévale (XIIIe-XVe siècles)." Revue de l'histoire des religions, no. 1 (March 1, 2006): 100–106. http://dx.doi.org/10.4000/rhr.4615.

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13

Martin, Hervé. "Christiane RAYNAUD, « À la hache », histoire et symbolique de la hache dans la France médiévale (XIIIe-XVe siècle)." Annales de Bretagne et des pays de l'Ouest, no. 110-2 (July 20, 2003): 241–44. http://dx.doi.org/10.4000/abpo.1437.

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14

Michaud, Francine. ""A la hache!": Histoire et symbolique de la hache dans la France médiévale (XIIIe-XVe siècles). Christiane Raynaud." Speculum 80, no. 1 (2005): 306–8. http://dx.doi.org/10.1017/s0038713400007442.

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15

Roccati, G. Matteo. "Christiane Raynaud, «A la hache!» Histoire et symbolique de la hache dans la France médiévale (XIIIe-XVe siècles)." Studi Francesi, no. 146 (XLIX | II) (November 1, 2005): 388. http://dx.doi.org/10.4000/studifrancesi.34263.

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16

Trémois, Claude-Marie. "Ne touchez pas la hache, de Jacques Rivette." Esprit Mars/avril, no. 3 (2007): 375. http://dx.doi.org/10.3917/espri.0703.0375.

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17

Chlebek, Jakub, Jan Korábečný, Rafael Doležal, et al. "In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier." Molecules 24, no. 7 (2019): 1340. http://dx.doi.org/10.3390/molecules24071340.

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In recent studies, several alkaloids acting as cholinesterase inhibitors were isolated from Corydalis cava (Papaveraceae). Inhibitory activities of (+)-thalictricavine (1) and (+)-canadine (2) on human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBChE) were evaluated with the Ellman’s spectrophotometric method. Molecular modeling was used to inspect the binding mode of compounds into the active site pocket of hAChE. The possible permeability of 1 and 2 through the blood–brain barrier (BBB) was predicted by the parallel artificial permeation assay (PAMPA) and logBB calculation. In v
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18

Bélénotti, P., A. Benyamine, C. Melenotte, et al. "Le syndrome d’Harlequin : un diagnostic en coup de hache !" La Revue de Médecine Interne 33 (June 2012): S190—S191. http://dx.doi.org/10.1016/j.revmed.2012.03.334.

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19

Fields, Warren Carl. "Theodore La Hache and Music in New Orleans, 1846-1869." American Music 8, no. 3 (1990): 326. http://dx.doi.org/10.2307/3052099.

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20

Mladenović, Milan, Biljana Arsić, Nevena Stanković, et al. "The Targeted Pesticides as Acetylcholinesterase Inhibitors: Comprehensive Cross-Organism Molecular Modelling Studies Performed to Anticipate the Pharmacology of Harmfulness to Humans In Vitro." Molecules 23, no. 9 (2018): 2192. http://dx.doi.org/10.3390/molecules23092192.

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Commercially available pesticides were examined as Mus musculus and Homo sapiens acetylcholinesterase (mAChE and hAChE) inhibitors by means of ligand-based (LB) and structure-based (SB) in silico approaches. Initially, the crystal structures of simazine, monocrotophos, dimethoate, and acetamiprid were reproduced using various force fields. Subsequently, LB alignment rules were assessed and applied to determine the inter synaptic conformations of atrazine, propazine, carbofuran, carbaryl, tebufenozide, imidacloprid, diuron, monuron, and linuron. Afterwards, molecular docking and dynamics SB stu
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21

Naldi, Marina, Gloria Brusotti, Gabriella Massolini, Vincenza Andrisano, Caterina Temporini, and Manuela Bartolini. "Bio-Guided Fractionation of Stem Bark Extracts from Phyllanthus muellarianus: Identification of Phytocomponents with Anti-Cholinesterase Activity." Molecules 26, no. 14 (2021): 4376. http://dx.doi.org/10.3390/molecules26144376.

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A combination of flash chromatography, solid phase extraction, high-performance liquid chromatography, and in vitro bioassays was used to isolate phytocomponents endowed with anticholinesterase activity in extract from Phyllanthus muellarianus. Phytocomponents responsible for the anti-cholinesterase activity of subfractions PMF1 and PMF4 were identified and re-assayed to confirm their activity. Magnoflorine was identified as an active phytocomponent from PMF1 while nitidine was isolated from PMF4. Magnoflorine was shown to be a selective inhibitor of human butyrylcholinesterase—hBChE (IC50 = 1
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22

GUILLEMIN, Hervé, and Joël VITAL. "La hache de Marignane (Bouches-du-Rhône) et la typologie des haches du type de Boismurie à l’âge du Bronze moyen." Documents d'Archéologie Méridionale, no. 29-30 (January 1, 2007): 7–18. http://dx.doi.org/10.4000/dam.1593.

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23

Rocha, Carolina. "Letrados' Masculinities in Un lugar en el mundo and Martín (Hache)." Bulletin of Hispanic Studies 89, no. 2 (2012): 163–76. http://dx.doi.org/10.3828/bhs.2012.13.

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24

Leroy, Florian. "Hommage au Pr. Jean-Claude Hache décédé le 12 octobre 2018." Revue Francophone d'Orthoptie 11, no. 4 (2018): 202. http://dx.doi.org/10.1016/j.rfo.2018.10.003.

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25

Artursson, Elisabet, Christine Akfur, Andreas Hörnberg, Franz Worek, and Fredrik Ekström. "Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis." Toxicology 265, no. 3 (2009): 108–14. http://dx.doi.org/10.1016/j.tox.2009.09.002.

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26

Dupuis, Olivier, and Vincent Deluz. "Le Jeu de la Hache: A Critical edition and dating discussion." Acta Periodica Duellatorum 5, no. 1 (2017): 3–62. http://dx.doi.org/10.1515/apd-2017-0001.

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Abstract Twenty-six years after the first edition and translation by Sydney Anglo in 1991 of the anonymous manuscript Le Jeu de la hache , many elements can still be significantly improved. This paper offers a completely new critical edition of the text, and a major revision of the translation. This article includes a detailed glossary as well as notes to discuss the many ambiguous passages in the original text. Finally, the studies of the language, the vocabulary, the dialect, the writing style and the physical document make it possible to refine the dating of the manuscript to the third quar
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27

Sáez-González, Jesús Miguel. "Ne touchez pas la hache / La duquesa de Langeais (Jacques Rivette)." Vivat Academia, no. 95 (May 15, 2008): 17. http://dx.doi.org/10.15178/va.2008.95.17-19.

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28

Wang, Zhi-Min, Xue-Mei Li, Gui-Min Xue, Wei Xu, Xiao-Bing Wang, and Ling-Yi Kong. "Synthesis and evaluation of 6-substituted 3-arylcoumarin derivatives as multifunctional acetylcholinesterase/monoamine oxidase B dual inhibitors for the treatment of Alzheimer’s disease." RSC Advances 5, no. 126 (2015): 104122–37. http://dx.doi.org/10.1039/c5ra22296f.

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29

Peters, Judith, Nicolas Martinez, Marie Trovaslet, et al. "Dynamics of human acetylcholinesterase bound to non-covalent and covalent inhibitors shedding light on changes to the water network structure." Physical Chemistry Chemical Physics 18, no. 18 (2016): 12992–3001. http://dx.doi.org/10.1039/c6cp00280c.

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30

Ruiz-Gurillo, Leonor, and Esther Linares-Bernabéu. "Subversive humor in Spanish stand-up comedy." HUMOR 33, no. 1 (2020): 29–54. http://dx.doi.org/10.1515/humor-2018-0134.

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AbstractThis paper aims to explore subversive humor in Spanish stand-up comedy by analyzing the work of two well-known Spanish female comedians, Eva Hache and Patricia Sornosa. In order to reach this goal, a corpus of these comedians’ performances has been collected, comprising a total of 25 monologues, which have been divided into humorous sequences, which come to a total of 76 in the corpus of Eva Hache and 37 for Patricia Sornosa. The qualitative and quantitative analysis has focused on subversive humorous sequences, which has shown that only 22.38% of the sequences from Eva Hache’s comic m
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31

Marion, J., M. Trovaslet, N. Martinez, et al. "Pressure-induced molten globule state of human acetylcholinesterase: structural and dynamical changes monitored by neutron scattering." Physical Chemistry Chemical Physics 17, no. 5 (2015): 3157–63. http://dx.doi.org/10.1039/c4cp02992e.

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32

Simon, Jean-François. "La Hache, outil de l’acte fondateur breton à Saint-Brieux, en Saskatchewan ?" Rabaska: Revue d'ethnologie de l'Amérique française, no. 1 (2003): 31. http://dx.doi.org/10.7202/201603ar.

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33

Maříková, Jana, Abdullah Al Mamun, Latifah Al Shammari, et al. "Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids." Molecules 26, no. 5 (2021): 1279. http://dx.doi.org/10.3390/molecules26051279.

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Two new minor Amaryllidaceae alkaloids were isolated from Hippeastrum × hybridum cv. Ferrari and Narcissus pseudonarcissus cv. Carlton. The chemical structures were identified by various spectroscopic (one- and two-dimensional (1D and 2D) NMR, circular dichroism (CD), high-resolution mass spectrometry (HRMS) and by comparison with literature data of similar compounds. Both isolated alkaloids were screened for their human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) inhibition activity. One of the new compounds, a heterodimer alkaloid of narcikachnine-type, named narciabdulii
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34

Nachon, Florian, Eugénie Carletti, Cyril Ronco, et al. "Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase." Biochemical Journal 453, no. 3 (2013): 393–99. http://dx.doi.org/10.1042/bj20130013.

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The multifunctional nature of Alzheimer's disease calls for MTDLs (multitarget-directed ligands) to act on different components of the pathology, like the cholinergic dysfunction and amyloid aggregation. Such MTDLs are usually on the basis of cholinesterase inhibitors (e.g. tacrine or huprine) coupled with another active molecule aimed at a different target. To aid in the design of these MTDLs, we report the crystal structures of hAChE (human acetylcholinesterase) in complex with FAS-2 (fasciculin 2) and a hydroxylated derivative of huprine (huprine W), and of hBChE (human butyrylcholinesteras
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35

Mahgoub, Mohamed Y., Awatef M. Elmaghraby, Abd-Elfttah A. Harb, João L. Ferreira da Silva, Gonçalo C. Justino, and M. Matilde Marques. "Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-a]Pyrimidines as New Acetylcholinesterase Inhibitors." Molecules 24, no. 12 (2019): 2306. http://dx.doi.org/10.3390/molecules24122306.

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A new series of thiazolo[3,2-a]pyrimidine bromide salt derivatives 7a–d were synthesized from 3,4-dihydropyrimidinethione precursors. The target compounds were fully characterized by 1D- and 2D-NMR, high resolution ESI-MS/MS and single crystal X-ray diffraction analysis, which confirmed a regioselective 5H cyclization of the dihydropyrimidinethiones. All target compounds were evaluated in vitro as human acetylcholinesterase (hAChE) inhibitors via an Ellman-based colorimetric assay and showed good inhibition activities (better than 70% at 10 µM and IC50 values in the 1 µM range). Molecular dock
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36

Wang, Li, Ignacio Moraleda, Isabel Iriepa, et al. "5-Methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5H-indolo[2,3-b]quinolin-11-amine: a highly potent human cholinesterase inhibitor." MedChemComm 8, no. 6 (2017): 1307–17. http://dx.doi.org/10.1039/c7md00143f.

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37

Radić, Zoran, Rakesh K. Sit, Zrinka Kovarik, et al. "Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases." Journal of Biological Chemistry 287, no. 15 (2012): 11798–809. http://dx.doi.org/10.1074/jbc.m111.333732.

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We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS. Starting with the initial lead oxime RS41A identified in our earlier study and extending to the azepine analog RS194B, reactivation rates for OP-hAChE conjugates formed by sarin, cyclosarin, VX, paraoxon, and tabun are enhanced severalfold in vitro. To analyze the mechanism of intrinsic reactivation of the OP-AChE conjugat
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38

Tison, Guillemette. "CRÉPIN (Thierry), HACHE-BISSETTE (Françoise) (dir.), Les Presses enfantines chrétiennes au XXe siècle." Histoire de l'éducation, no. 127 (July 1, 2010): 137–38. http://dx.doi.org/10.4000/histoire-education.2215.

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39

Hecquet, Vincent. "Thierry Crépin, François Hache-Bissette, dirs, Les presses enfantines chrétiennes au XXe siècle." Questions de communication, no. 19 (June 30, 2011): 300–303. http://dx.doi.org/10.4000/questionsdecommunication.339.

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40

Abaz, B., Alain Beyneix, and A. Mateu. "Une hache de type de Rosnoën à Gontaud-de-Nogaret (Lot-et-Garonne)." Bulletin de la Société préhistorique française 89, no. 9 (1992): 277–78. http://dx.doi.org/10.3406/bspf.1992.9534.

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41

Radić, Zoran, Rakesh K. Sit, Edzna Garcia, et al. "Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates." Chemico-Biological Interactions 203, no. 1 (2013): 67–71. http://dx.doi.org/10.1016/j.cbi.2012.08.014.

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42

Sit, Rakesh K., Zoran Radić, Valeria Gerardi, et al. "New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases." Journal of Biological Chemistry 286, no. 22 (2011): 19422–30. http://dx.doi.org/10.1074/jbc.m111.230656.

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We describe here the synthesis and activity of a new series of oxime reactivators of cholinesterases (ChEs) that contain tertiary amine or imidazole protonatable functional groups. Equilibration between the neutral and protonated species at physiological pH enables the reactivators to cross the blood-brain barrier and distribute in the CNS aqueous space as dictated by interstitial and cellular pH values. Our structure-activity analysis of 134 novel compounds considers primarily imidazole aldoximes and N-substituted 2-hydroxyiminoacetamides. Reactivation capacities of novel oximes are rank orde
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43

Renou, Julien, José Dias, Guillaume Mercey, et al. "Synthesis and in vitro evaluation of donepezil-based reactivators and analogues for nerve agent-inhibited human acetylcholinesterase." RSC Advances 6, no. 22 (2016): 17929–40. http://dx.doi.org/10.1039/c5ra25477a.

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Donepezil-based reactivators 1–3 show a better ability (8 fold higher) than pralidoxime to reactivate VX-hAChE, and oxime 2 is 5 to 11 fold more efficient than pralidoxime and HI-6 respectively to reactivate of VX-hBChE.
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44

Kohelová, Eliška, Rozálie Peřinová, Negar Maafi та ін. "Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease". Molecules 24, № 7 (2019): 1307. http://dx.doi.org/10.3390/molecules24071307.

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Twelve derivatives 1a–1m of the β-crinane-type alkaloid haemanthamine were developed. All the semisynthetic derivatives were studied for their inhibitory potential against both acetylcholinesterase and butyrylcholinesterase. In addition, glycogen synthase kinase 3β (GSK-3β) inhibition potency was evaluated in the active derivatives. In order to reveal the availability of the drugs to the CNS, we elucidated the potential of selected derivatives to penetrate through the blood-brain barrier (BBB). Two compounds, namely 11-O-(2-methylbenzoyl)-haemanthamine (1j) and 11-O-(4-nitrobenzoyl)-haemantham
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45

Ruiz gurillo, Leonor. "Eva Hache y El Club de la Comedia: del guión monológico al registro dialógico." Onomázein Revista de lingüística, filología y traducción 28 (December 5, 2013): 148–61. http://dx.doi.org/10.7764/onomazein.28.5.

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46

Lequellec, Jean-Loïc. "Mégalithes et traditions populaires. La hache et le marteau de vie et de mort." Bulletin de la Société préhistorique française 93, no. 3 (1996): 287–97. http://dx.doi.org/10.3406/bspf.1996.10169.

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Piazzi, Lorna, Andrea Cavalli, Francesco Colizzi, et al. "Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds." Bioorganic & Medicinal Chemistry Letters 18, no. 1 (2008): 423–26. http://dx.doi.org/10.1016/j.bmcl.2007.09.100.

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48

Blumenthal, Donald K., Xiaolin Cheng, Mikolai Fajer, et al. "Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects." Journal of Biological Chemistry 297, no. 3 (2021): 101007. http://dx.doi.org/10.1016/j.jbc.2021.101007.

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49

Ueda, Hiroto. "Lematización de los datos de CODEA y su utilización en análisis cuantitativos sobre la eñe y la hache muda." Philologia hispalensis 1, no. 33 (2019): 161–78. http://dx.doi.org/10.12795/ph.2019.v33.i01.10.

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50

Verlinden, Colette. "Nouvelle interprétation du décor incisé sur une double hache en bronze supposée provenir de Voros." Bulletin de correspondance hellénique. Supplément 11, no. 1 (1985): 135–49. http://dx.doi.org/10.3406/bch.1985.5274.

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