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Rozprawy doktorskie na temat „Lactate dehydrogenase”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Shu, Hun-Chi. "D-lactid acid analysis using sequential injection analysis and amperometric biosensor." Lund : Dept. of Biotechnology, Lund University, 1994. http://catalog.hathitrust.org/api/volumes/oclc/38950881.html.

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2

Nobbs, Timothy J. "Protein engineering of E. coli malate dehydrogenase and B. stearothermophilus lactate dehydrogenase." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293546.

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3

Dempster, Sally. "Lactate dehydrogenase : studies towards the design, synthesis and co-crystallisation of bisubstrate inhibitors." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.594762.

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4

Christopher, Mary Elizabeth. "Characterization of hypoxically induced lactate dehydrogenase in maize." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq22968.pdf.

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5

Higham, Christopher W. "A study of lactate dehydrogenase from Plasmodium falciparum." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299529.

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6

Diez-Aguirre, Jesus Javier. "A cold-active lactate dehydrogenase from an Antarctic bacterium." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312140.

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7

Haghayegh, Jahromi Neda, and Gheinani Ali Hashemi. "RNA Silencing of Lactate Dehydrogenase Gene in Rhizopus oryzae." Thesis, Högskolan i Borås, Institutionen Ingenjörshögskolan, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-20404.

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RNA silencing with direct delivery of siRNA has been used to suppress ldhA gene expression in filamentous fungus Rhizopus oryzae. Here, for the first time we show that, introducing small interfering RNA which consequently forms silencing complexes can alter the gene expression and we report a significant reduction of lactic acid production for isolates containing short (25 nt) synthetic siRNA. In all samples lactic acid production was reduced comparing with wild types. The average concentration of lactic acid production by Rhizopus oryzae during batch fermentation process where glucose has bee

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8

Lomas, Andrew Philip. "Towards a small molecule inhibitor of Lactate Dehydrogenase-A." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:d7f1416e-0d3d-4b4e-af62-7bbf4d52cf90.

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Lactate Dehydrogenase-A (LDH-A) is up-regulated in a broad array of cancers and is associated with poor prognosis. Involved in the hypoxic response, LDH-A is a HIF-1 target and is responsible for the enzymatic reduction of pyruvate to lactate. This is important for several reasons, chiefly (1) the regeneration of NAD+ which feeds back into earlier glycolytic stages and (2) the depletion of intracellular pyruvate concentrations. High intracellular pyruvate is known to inhibit HDACs and is associated with increased apoptosis. LDH-A is also known to be controlled by oncogenes such as c-Myc sugges

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9

Silcock, Alan J. "Enantioselective synthesis and cyclisation studies of 2-hydroxy esters." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299530.

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10

Shoemark, Deborah Karen. "The kinetic characterization of the lactate dehydrogenase enzyme from Plasmodium falciparum." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326677.

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11

Banfield, Mark James. "Structural studies of antibody engineering and lactate dehydrogenase from P. falciparum." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389341.

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12

Sleigh, Roger N. "An analysis of the folding of lactate dehydrogenase from Bacillus stearothermophilus." Thesis, University of Bristol, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294581.

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13

Wilks, Helen M. "Design and synthesis of new enzymes on the lactate dehydrogenase framework." Thesis, University of Bristol, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282796.

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14

Kim, Yuan Hwan. "Lactate dehydrogenase regulation of the metmyoglobin reducing system to improve color stability of bovine muscles through lactate enhancement." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2966.

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15

Hateley, Martin John. "Studies in the dehydrogenase catalysed reduction of 2-ketocarboxylic acids." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299531.

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16

Baker, Douglas John. "Chaperonins for the assisted refolding of protein." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327336.

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17

Gibbs, Gary. "Synthetic strategies towards hydroxylated alkaloids." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387484.

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18

Muniz, Gysella, Jennifer Hidalgo-Campos, Maria del Carmen Valdivia-Tapia, Nader Shaikh, and Nilton Yhuri Carreazo. "Successful management of chylothorax with etilefrine: case report in 2 pediatric patients." American Academy of Pediatrics, 2018. http://hdl.handle.net/10757/624655.

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El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.<br>Chylothorax is defined as the accumulation of chyle within the pleural space. Originally described in 1917 by Pisek, it is the most common cause of pleural effusion in the neonatal period. The leading cause of chylothorax is laceration of the thoracic duct during surgery, which occurs in 0.85% to 6.6% of children undergoing cardiothoracic surgery. Few authors of reports in the literature have looked at etilefrine, a relatively unknown sympathom

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19

Mulholland, Peter. "M-subunit lactate dehydrogenase in aspirated fluids from benign and malignant lesions." Thesis, University of Ulster, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328198.

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20

Hart, K. W. "An investigation into the molecular basis of substrate specificity in lactate dehydrogenase." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235201.

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21

Colebrook, Steve Michael. "The D- and L- Lactate dehydrogenase enzyme families : relatedness, cooperativity and mechanism." Thesis, University of Bristol, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386153.

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22

Mi, Yanli. "Protection Mechanisms of Excipients on Lactate Dehydrogenase during Freeze-Thawing and Lyophilization." View the abstract Download the full-text PDF version, 2002. http://etd.utmem.edu/WORLDACCESS/ymi/default.htm.

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23

Sprysak, Kathleen Anne. "Induction of alcohol dehydrogenase, lactate dehydrogenase, and alanine aminotransferase gene expression in roots of Arabidopsis thaliana exposed to hypoxia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq21209.pdf.

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24

Choi, Seoung-Ryoung. "Design, synthesis, and biological evaluation of inhibitors of lactate dehydrogenase from Plasmodium falciparum/." Full text available from ProQuest UM Digital Dissertations, 2006. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1394651391&SrchMode=2&sid=5&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1216830289&clientId=22256.

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25

Chen, Yudan. "Stabilization of Lactate Dehydrogenase and Peptide Separation via Electrophoresis Using A Pluronic Polymer." Miami University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=miami1595358926594776.

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26

Kavanagh, Kathryn Louise. "Structural studies of three NAD(P)H-dependent enzymes involved in sugar metabolism : mannitol dehydrogenase, xylose reductase, and lactate dehydrogenase /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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27

蔡昌明 and Chang-ming Stephen Tsoi. "Biochemical and molecular studies of Lactate Dehydrogenase Isozymes inthe freshwater eels, anguilla japonica (Temminck & Schlegel) andAnguilla rostrata (Le Sueur)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31233922.

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28

Tsoi, Chang-ming Stephen. "Biochemical and molecular studies of Lactate Dehydrogenase Isozymes in the freshwater eels, anguilla japonica (Temminck & Schlegel) and Anguilla rostrata (Le Sueur) /." [Hong Kong] : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13637563.

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29

Haggblom, Lisa Marie. "Changes in myoglobin and lactate dehydrogenase in muscle tissues of a diving bird, the pigeon guillemot (Cepphus columba), during maturation." Thesis, University of Oregon theses, Dept. of Biology, M.S., 1987, 1987. http://hdl.handle.net/1794/9517.

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ix, 46 leaves : ill. ; 29 cm Notes Typescript Thesis (M.S.)--University of Oregon, 1987 Includes vita and abstract Bibliography: leaves 37-46 Another copy on microfilm is located in Archives

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30

Schmidt, Brian P. "The Use of Lactate Dehydrogenase for the Detection of Murine Natural Killer Cell Function." Youngstown State University / OhioLINK, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=ysu999616997.

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31

Razeto, Adelia. "Structural investigation on enzymatic stereoselectivity : two case studies: L. bulgaricus D-lactate dehydrogenase and chymotrypsin." Thesis, University of York, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323690.

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32

Dunn, Cameron R. "A crystallographic study of structural changes in L-lactate dehydrogenase induced by the binding substrate." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330195.

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33

Smuts, Celia. "Evaluation of lactate dehydrogenase (LDH) activity in body cavity effusions from dogs, cats and horses." Thesis, Smuts, Celia (2014) Evaluation of lactate dehydrogenase (LDH) activity in body cavity effusions from dogs, cats and horses. Masters by Research thesis, Murdoch University, 2014. https://researchrepository.murdoch.edu.au/id/eprint/24333/.

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Lactate dehydrogenase (LDH) activity is often measured in human effusions to help in differentiating between transudates and exudates. Few studies have been performed using samples of effusions from animals. In the present study LDH activity was measured in 107 effusion samples (pleural, abdominal and pericardial) from dogs, cats and horses. LDH activity was found to be significantly increased in exudates compared to transudates in all species tested. Different methods of measuring LDH activity (wet chemistry using a lactate to pyruvate (L-P) and pyruvate to lactate (P-L) reaction, and a dry c

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34

Balfour, David Leigh. "Ontogenetic Changes and Environmental Hypoxia: Responses of Two Fish Species to Low Oxygen Concentrations at Early Life Stages." Diss., Virginia Tech, 1999. http://hdl.handle.net/10919/26467.

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Hypoxia refers to any condition in which the water is less than fully saturated with oxygen. Although it is generally accepted that adults are more tolerant of hypoxic conditions than larval stages, there is little information to support this assumption. To determine whether reduced concentrations of dissolved oxygen (DO) affect fishes differently during various early life stages, I examined the responses of two species of fish (fathead minnows (Pimephales promelas) and rainbow trout (Oncorhynchus mykiss)) exposed to low dissolved oxygen concentrations at different ages during the first 100

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35

Griffith, Steven L. "Serum creatine phosphokinase and lactate dehydrogenase activities in the rat after variable durations of downhill running." Virtual Press, 1986. http://liblink.bsu.edu/uhtbin/catkey/447237.

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Serum lactage dehydrogenase and creatine phosphokinase level were studied in sixty male Sprague-Dawley rats weighing 400 to 680 grams. Five groups of ten rats each ran forty-five minutes (16 m/min) with variable percentages of the total bout consisting of downhill running (16° incline): Group I- 0%, Group II- 22%, Group III- 50%, Group IV- 78%, Group V- 100% downhill. Group VI consisted of ten sedentary controls. Serial blood samples were obtained immediately after exercise, 12, 24, 36, 48, and 60 hours found to exist between a non-trained rat’s weight and its ability to finish the exercis

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36

Turgut, Dilek. "Overproduction of the active lactate dehydrogenase from Plasmodium falciparum opens a route to obtain new antimalarials." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389088.

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37

Aira, Naomi. "Lactate Dehydrogenase and Citrate Synthase activity in cardiac and skeletal muscle of lowland and highland tinamous." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-98058.

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Tinamous (Tinamidae) have the smallest heart in relation to body mass compared to any other flying bird today (Bishop 1997). This means that heart size is likely to restrict aerobic metabolism. Tinamous inhabit areas from sea level to 4800 m a.s.l., which means that the high altitude living species, Nothoprocta ornata (NO), is exposed to hypoxia. In this study the activity of the two metabolic enzymes Lactate Dehydrogenase (LDH) and Citrate Synthase (CS) was measured and the ratio between the enzyme activities calculated to examine if the small heart of the tinamous affects their aerobic/anaer

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38

Rosato, Paula Nunes [UNESP]. "Correlação dos achados bioquímicos na identificação de efusões exsudativas e transudativas em cães." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/101231.

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Made available in DSpace on 2014-06-11T19:31:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-12-10Bitstream added on 2014-06-13T19:01:33Z : No. of bitstreams: 1 rosato_pn_dr_jabo.pdf: 832916 bytes, checksum: 102a485aedf4708a456e694f64bbf38d (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A avaliação laboratorial de uma efusão é relevante para que, em conjunto com os sinais clínicos apresentados pelo paciente, possa ser firmado um possível diagnóstico e instituída ação terapêutica adequada. Assim sendo, a classificação de uma efusão em transudato ou e

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39

Hirata, Rosario Dominguez Crespo. "Determinação das atividades da ATP:creatina-fosfotransferase (E.C. 2.7.3.2) e da L-lactato:NAD-oxidorredutase (E.C. 1.1.1.27) e de suas isoenzimas em indivíduos portadores de neoplasias gástricas." Universidade de São Paulo, 1987. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-25032008-154332/.

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As atividades enzimáticas e isoenzimáticas da CK e da LD foram determinadas nos tecidos gástricos neoplásico e da margem de ressecção e no soro de indivíduos com adenocarcinoma de estômago, submetidos à gastrectomia. O tecido gástrico neoplásico aapresentou índices CKBB/Cktotal e LD5/LD1, bem como atividade da LD5, superiores aos da margem de ressecção correspondente. No pré-operatório, os indivíduos estudados apresentaram elevação da atividade sérica da CK BB (100%) e da CK MB (69%). Este fato, possivelmente, resultou da liberação dessas isoenzimas pelo próprio neoplasma ou, também pelo tecid

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40

Moura, Dagnou Pessoa de. "Relação entre marcadores de dano tecidual e desempenho físico com a intensidade e ações técnicas no jogo de futebol sub-20." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/155938.

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Submitted by DAGNOU PESSOA DE MOURA (dagnou@hotmail.com) on 2018-09-10T01:25:41Z No. of bitstreams: 1 Dissertação Dagnou.pdf: 1760297 bytes, checksum: 256f3fc718423dfdcffb0e03c3a2a8d1 (MD5)<br>Approved for entry into archive by Lucilene Cordeiro da Silva Messias null (lubiblio@bauru.unesp.br) on 2018-09-10T13:58:32Z (GMT) No. of bitstreams: 1 moura_dp_me_bauru.pdf: 1342639 bytes, checksum: 910b111b3688ea6717844a4b16565116 (MD5)<br>Made available in DSpace on 2018-09-10T13:58:33Z (GMT). No. of bitstreams: 1 moura_dp_me_bauru.pdf: 1342639 bytes, checksum: 910b111b3688ea6717844a4b16565116 (MD

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41

Mendonça, Ivone Camargo Damasceno. "Biomarcadores de lesão na nefropatia falciforme." Universidade Federal de Sergipe, 2012. https://ri.ufs.br/handle/riufs/3764.

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Sickle cell anemia is a disorder of genetic hemoglobin more common around the world, characterized by the presence of abnormal hemoglobin S. The phenomena of vaso-occlusion and anemia characteristics cause tissue damage leading to organ damage, including the kidneys. The various types of renal abnormalities occur primarily in the renal medulla. Clinical manifestations of sickle cell nephropathy start early, often before one year of age with glomerular hyperfiltration, hyposthenuria, renal tubular acidosis distal and, over time, increase in albuminuria. The lactate dehydrogenase (LDH) is consid

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42

Williams, Wendy Ann 1960. "Changes in blood parameters, muscle myoglobin and muscle lactate dehydrogenase of the Common Murre (Uria aalge) during maturation." Thesis, Thesis (M.S.)--University of Oregon, 1992, 1992. http://hdl.handle.net/1794/9933.

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Typescript. Includes vita and abstract. Bibliography: Includes bibliographical references (leaves 95-99). Description: xii, 99 leaves : ill. ; 29 cm.<br>Blood oxygen carrying capacity, myoglobin levels and LDH isozyme compositions in the heart, gastrocnemius and pectoralis muscles were determined in Common Murre adults and during maturation of the chick at sea. Oxygen stores in the chick (hemoglobin, hematocrit, muscle myoglobin) increased significantly with growth. High levels of the aerobic isozyme, LDH 1, were maintained throughout maturation in the heart. All five LDH isozymes w

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43

Hunter, I. "A study of the intracellular and extracellular levels of lactate dehydrogenase and its isoenzymes in the megaloblastic anaemias." Thesis, Nottingham Trent University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372842.

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44

Nguyen, Boisse Thanh Thuy. "Microbiocapteurs conductimétriques utilisant des oxydoréductases : de la conception à l’application à l’environnement et l’agroalimentaire." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10111/document.

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Les biocapteurs sont des moyens d'analyse en plein essor à la fois rapides, sélectifs et peu coûteux applicables à des domaines extrêmement variés (environnement, santé, agroalimentaire,…). Dans ce type d'outil, un élément sensible de nature biologique (anticorps, enzyme, microorganisme, ADN…) doté d'un pouvoir de reconnaissance pour un analyte ou un groupe d'analytes est associé à un transducteur pouvant être de type électrochimique, optique ou thermique. Dans ce travail, nous nous sommes intéressés au développement de trois biocapteurs utilisant des enzymes de la famille des oxydo-réductases

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45

Wang, Zhiyu, and 王志宇. "Identification and characterization of bioactive compounds in Spatholobus suberectus targeting on LDH-A in breast cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48329423.

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Although clinical outcomes of some cancer have been greatly improved by advancements made in surgery, chemo or radiotherapy and development of novel strategies such as molecular targeted therapy, Traditional Chinese Medicine (TCM) is particularly appreciated for cancer therapy in China based on its 5,000-year-old history, well established theoretical system and numerous exciting case reports. However, due to lack of quality assurance, laboratory evidences and well-designed clinical trials, TCM always encounters much skepticism and pessimism by the West. The study aims to identify the bioactiv

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46

Kyomuhangi, Annet. "DEVELOPMENT AND EVALUATION OF NONRADIOACTIVE METHODS FOR MONITORING T LYMPHOCYTE RESPONSE TO EQUINE ARTERITIS VIRUS (EAV) IN HORSES." UKnowledge, 2019. https://uknowledge.uky.edu/gluck_etds/39.

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Target cell lysis is the hallmark of immune effector responses of cytotoxic T lymphocytes (CTL), natural killer (NK) cells, and monocytes. The most commonly used assay to measure target cell lysis is the 51Cr release assay and is considered the ‘gold standard’. However, this assay has many disadvantages that limit its use by most laboratories. Thus, several alternative assays have been developed. Some of these alternative assays are more sensitive, easy to perform and do not use radioactive elements. In this study, four of these assays were evaluated for their ability to detect antigen- specif

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47

Marschke, Ronald James. "Milk enzymes as diagnostic indicators of milk secretory disorders." Thesis, Queensland University of Technology, 1987. https://eprints.qut.edu.au/36796/1/36796_Marschke_1987.pdf.

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Studies were carried out on two enzymes of bovine milk, N-acetyl-8-D-glucosaminidase (NAGase) and lactate dehydrogenase (LDH), which are indicators of the udder disease mastitis. The main objective of this study was to determine the origins of NAGase and LDH in milk. The approach used was to examine the differences in multiple forms of the enzymes in mammary gland, blood leucocytes and blood plasma by various separation procedures. The molecular weight forms of NAGase in mammary gland and polymorphonuclear leucocytes showed pH-dependent association-dissociation behaviour on gel filtration,

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48

Young, Sarah Jane. "The detection of organic aqueous pollutants using inhibition of enzyme activity : a model system based on lactate dehydrogenase and pentachlorophenol." Thesis, University of the West of England, Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311878.

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49

Passaquin, Anne-Catherine. "Interferon et syntheses hormono-inductibles : etude de l'effet de l'interferon sur la synthese de la lactate deshydrogenase inductible par les catecholamines." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13109.

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50

Mohan, Anand. "Myoglobin redox form stabilization : role of metabolic intermediates and NIR detection." Diss., Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/2310.

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