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Artykuły w czasopismach na temat "Latent membrane protein one"

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Zhang, Yujiao, Yinzhong Shen, Lin Yin, et al. "Plasma Membrane Proteomic Profile Discovers Macrophage-capping Protein Related to Latent HIV-1." Current HIV Research 17, no. 1 (2019): 42–52. http://dx.doi.org/10.2174/1570162x17666190506155222.

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Background:Due to the persistence of latent HIV-infected cellular reservoirs, HIV virus can not be eradicated completely.Objective:To identify proteins related to HIV latency, we performed a subcellular proteomic study in HIV latent cell lines.Method:An established HIV-1 latent cell model (J-Lat Tat-GFP Clone A7 cells, A7 cells) and its parental cell line (Jurkat cells) were used. The plasma membrane (PM) fraction from cultured cells was enriched through aqueous two-phase partition. PM proteins were extracted and then separated using two-dimensional electrophoresis (2DE). Differentially expres
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Diduk, S. V., K. V. Smirnova, and V. E. Gurtsevitch. "THE INFLUENCE OF POINT MUTATIONS IN THE EPSTEIN-BARR VIRUS LMP1 ONCOGENE ON THE CELL CYTOSKELETON AND ACTIVATION OF INDUCIBLE FORM OF NO SYNTHASE." Annals of the Russian academy of medical sciences 67, no. 3 (2012): 62–67. http://dx.doi.org/10.15690/vramn.v67i3.187.

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One of the latent proteins encoded by the Epstein−Barr virus (EBV), the latent membrane protein 1 (LMP1), plays a key role in developing of EBV-associated human malignancies. Polymorphism of LMP1 protein is its characteristic feature. Some specific mutations in LMP1 genome have previously been detected in different geographic regions, however, the influence of these mutations on functional activity of LMP1 was not still determined. In this study we demonstrated for the first time the significance of individual point mutations among common ones observed in LMP1 and their combination on activati
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Murray, R. J., M. G. Kurilla, J. M. Brooks, et al. "Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies." Journal of Experimental Medicine 176, no. 1 (1992): 157–68. http://dx.doi.org/10.1084/jem.176.1.157.

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Epstein-Barr virus (EBV), a human herpes virus with oncogenic potential, persists in B lymphoid tissues and is controlled by virus-specific cytotoxic T lymphocyte (CTL) surveillance. On reactivation in vitro, these CTLs recognize EBV-transformed lymphoblastoid cell lines (LCLs) in an HLA class I antigen-restricted fashion, but the viral antigens providing target epitopes for such recognition remain largely undefined. Here we have tested EBV-induced polyclonal CTL preparations from 16 virus-immune donors on appropriate fibroblast targets in which the eight EBV latent proteins normally found in
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Liebowitz, D., R. Kopan, E. Fuchs, J. Sample, and E. Kieff. "An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes." Molecular and Cellular Biology 7, no. 7 (1987): 2299–308. http://dx.doi.org/10.1128/mcb.7.7.2299-2308.1987.

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The Epstein-Barr virus (EBV) latent infection membrane protein (LMP) is likely to be an important mediator of EBV-induced cell proliferation, since it is one of the few proteins encoded by the virus in latent infection and since production of this protein in Rat-1 cells results in their conversion to a fully transformed phenotype. LMP was previously noted to localize to patches at the cell periphery. In this paper we examine the basis of LMP patching in EBV-infected, transformed lymphocytes. Our data indicate that LMP is associated with the cytoskeletal protein vimentin. Although LMP is fully
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Liebowitz, D., R. Kopan, E. Fuchs, J. Sample, and E. Kieff. "An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes." Molecular and Cellular Biology 7, no. 7 (1987): 2299–308. http://dx.doi.org/10.1128/mcb.7.7.2299.

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The Epstein-Barr virus (EBV) latent infection membrane protein (LMP) is likely to be an important mediator of EBV-induced cell proliferation, since it is one of the few proteins encoded by the virus in latent infection and since production of this protein in Rat-1 cells results in their conversion to a fully transformed phenotype. LMP was previously noted to localize to patches at the cell periphery. In this paper we examine the basis of LMP patching in EBV-infected, transformed lymphocytes. Our data indicate that LMP is associated with the cytoskeletal protein vimentin. Although LMP is fully
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Engels, Niklas, Mark Merchant, Rajita Pappu, Andrew C. Chan, Richard Longnecker, and Jürgen Wienands. "Epstein-Barr Virus Latent Membrane Protein 2a (Lmp2a) Employs the Slp-65 Signaling Module." Journal of Experimental Medicine 194, no. 3 (2001): 255–64. http://dx.doi.org/10.1084/jem.194.3.255.

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In latently infected B lymphocytes, the Epstein-Barr virus (EBV) suppresses signal transduction from the antigen receptor through expression of the integral latent membrane protein 2A (LMP2A). At the same time, LMP2A triggers B cell survival by a yet uncharacterized maintenance signal that is normally provided by the antigen receptor. The molecular mechanisms are unknown as LMP2A-regulated signaling cascades have not been described so far. Using a novel mouse model we have identified the intracellular adaptor protein Src homology 2 (SH2) domain–containing leukocyte protein (SLP)-65 as a critic
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Kaykas, Ajamete, Kathleen Worringer, and Bill Sugden. "LMP-1's Transmembrane Domains Encode Multiple Functions Required for LMP-1's Efficient Signaling." Journal of Virology 76, no. 22 (2002): 11551–60. http://dx.doi.org/10.1128/jvi.76.22.11551-11560.2002.

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ABSTRACT The latent membrane protein-1 (LMP-1) of Epstein-Barr virus (EBV) contributes to the proliferation of infected B lymphocytes by signaling through its binding to cellular signaling molecules. It apparently mimics members of the tumor necrosis factor receptor family, in particular, CD40, by binding a similar set of cellular molecules as does CD40. LMP-1 differs dramatically in its structure from CD40. LMP-1 has six membrane-spanning domains as opposed to CD40's one. LMP-1 also differs from CD40 in its apparent independence of a ligand for its signaling. We have examined the role of LMP-
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Lee, Song Hee, Katie Caviness, Emily R. Albright, et al. "Long and Short Isoforms of the Human Cytomegalovirus UL138 Protein Silence IE Transcription and Promote Latency." Journal of Virology 90, no. 20 (2016): 9483–94. http://dx.doi.org/10.1128/jvi.01547-16.

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ABSTRACTThe UL133–138 locus present in clinical strains of human cytomegalovirus (HCMV) encodes proteins required for latency and reactivation in CD34+hematopoietic progenitor cells and virion maturation in endothelial cells. The encoded proteins form multiple homo- and hetero-interactions and localize within secretory membranes. One of these genes, UL136 gene, is expressed as at least five different protein isoforms with overlapping and unique functions. Here we show that another gene from this locus, the UL138 gene, also generates more than one protein isoform. A long form of UL138 (pUL138-L
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Moskalev, Alexander V., Boris Yu Gumilevsky, Vasiliy Ya Apchel, and Vasiliy N. Tsygan. "The role of viruses in cell transformation and oncogenesis." Bulletin of the Russian Military Medical Academy 25, no. 1 (2023): 133–44. http://dx.doi.org/10.17816/brmma121327.

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The data of modern scientific literature characterizing individual mechanisms of transformation of normal cells and various stages of oncogenesis associated with viruses were analyzed. The data of sequencing of tumor genomes and amino acid sequences indicate that most tumors are a consequence of the accumulation of sequential mutations, a significant contribution to the formation of which was made by oncogenic viruses. Processes that alter or impair the functioning of signaling pathways can contribute to transformation and oncogenesis. The phosphorylation of the ribosomal protein S6 by protein
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Dudziak, Diana, Arnd Kieser, Ulrike Dirmeier та ін. "Latent Membrane Protein 1 of Epstein-Barr Virus Induces CD83 by the NF-κB Signaling Pathway". Journal of Virology 77, № 15 (2003): 8290–98. http://dx.doi.org/10.1128/jvi.77.15.8290-8298.2003.

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ABSTRACT Epstein-Barr virus (EBV) infects human resting B cells and transforms them in vitro into continuously growing lymphoblastoid cell lines (LCLs). EBV nuclear antigen 2 (EBNA2) is one of the first viral proteins expressed after infection. It is able to transactivate viral as well as cellular target genes by interaction with cellular transcription factors. EBNA2 target genes can be studied easily by using an LCL (ER/EB2-5) in which wild-type EBNA2 is replaced by an estrogen-inducible EBNA2. Since the cell surface molecule CD83, a member of the immunoglobulin superfamily and a marker for m
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Rozprawy doktorskie na temat "Latent membrane protein one"

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Patsos, Georgios. "Epstein-Barr virus latent membrane protein 2A." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399923.

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Chen, Fu. "Epstein-Barr virus (EBV) latent membrane protein LMP2A /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-589-5/.

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Johansson, Pegah. "Regulation of the Epstein-Barr virus latent membrane protein 1 expression /." Göteborg : Göteborg University, Institute of Biomedicine, Dept. of Clinical Chemistry and Transfusion Medicine, 2007. http://hdl.handle.net/2077/8509.

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Lin, San-san, and 林新新. "Mechanism of Epstein-Barr virus latent membrane protein 1-regulated cytokine expression." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30152033.

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Marshall, Neil A. "The role of EBV latent membrane protein 1 induced regulatory T-cells in latent infection and Hodgkin lymphoma." Thesis, University of Aberdeen, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430397.

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Healthy EBV seropositive donors tested for the ability to mount Th responses against LMP1 responded with secretion of high levels of the immunosuppressive cytokine IL-10 which was secreted from cells phenotypically analogous to the Tr1 class of regulatory T-cells.  The epitopes inducing this IL-10 secretion were clustered in the hydrophobic, transmembrane half of the protein that corresponded to a cluster of high affinity MHC class II binding domains.  Since the LMP1 induced TO cells could effectively suppress immune responses in an IL- 10 dependent manner, it seems likely that the induction o
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Liu, Yu, and 劉鈺. "Biological properties of EBV-encoded latent membrane protein 1 in nasopharyngeal epithelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31242078.

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McLean, Adele. "An investigation into the early stages of latent membrane protein 1 induced carcinogenesis." Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437951.

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Curran, John Andrew. "The oncogenic activity of the latent membrane protein of EBV in transgenic mice." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388552.

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Vaysberg, Maria. "Characterization of latent membrane protein 1 induced signal transduction in B cell lymphomas /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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Liu, Yu. "Biological properties of EBV-encoded latent membrane protein 1 in nasopharyngeal epithelial cells /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23001008.

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Książki na temat "Latent membrane protein one"

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George, Juliet Helen. Studies on the effects of Epstein-Barr virus-encoded latent membrane protein 2 (LMP2) on human epithelial cells. University of Birmingham, 2000.

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Glasier, Mary-Ann M. A role for SHP-1 and Vav in the abrogation of B cell receptor signal transduction by latent membrane protein 2 (LMP2). National Library of Canada = Bibliothèque nationale du Canada, 1999.

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Wang, David Derwoei. The role of Epstein-Barr virus latent infection membrane protein (LMP) in cell transformation. 1988.

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Analisis Latent Membrane Protein 1 (LMP1) Epstein-Barr Virus (EBV) sebagai antigen target pada Kanker Nasofaring (KNF): Upaya pengembangan Therapeutic Polyepitope-Vaccine di Indonesia. Lembaga Penelitian, Universitas Airlangga, 2007.

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Heidet, Laurence, Bertrand Knebelmann, and Marie Claire Gubler. Alport syndrome. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0323.

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The diagnosis of Alport syndrome is suspected from the clinical features and confirmed by identifying the almost pathognomonic ultrastructural changes to the basement membrane in a family member with early disease (so that glomeruli are not too sclerosed), or in modern times by identifying a causative mutation in one or more of the three implicated COL4 genes. Genetic testing is becoming simpler and cheaper, but is still out of the reach of many. Eighty-five per cent of cases are caused by COL4A5 mutations and 10–15% by autosomal recessive disease. A significant proportion of morbidity in X-li
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Alexander, D. J., N. Phin, and M. Zuckerman. Influenza. Edited by I. H. Brown. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0037.

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Influenza is a highly infectious, acute illness which has affected humans and animals since ancient times. Influenza viruses form the Orthomyxoviridae family and are grouped into types A, B, and C on the basis of the antigenic nature of the internal nucleocapsid or the matrix protein. Infl uenza A viruses infect a large variety of animal species, including humans, pigs, horses, sea mammals, and birds, occasionally producing devastating pandemics in humans, such as in 1918 when it has been estimated that between 50–100 million deaths occurred worldwide.There are two important viral surface glyc
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Simpson, A., E. Aarons, and R. Hewson. Marburg and Ebola viruses. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0038.

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Infection with Marburg and Ebola viruses cause haemorrhagic fevers that are characterized by organ malfunction, bleeding complications, and high mortality. The viruses are members of the family Filoviridae, a group of membrane-enveloped filamentous RNA viruses. Five distinct species of the genus Ebolavirus have been reported; the genus Marburgvirus contains only one species. Both Marburg and Ebola virus diseases are zoonotic infections whose primary hosts are thought to be bats. The initial human infection is acquired from wildlife and subsequent person-to-person spread propagates the outbreak
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Części książek na temat "Latent membrane protein one"

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Cen, Osman, and Richard Longnecker. "Latent Membrane Protein 2 (LMP2)." In Epstein Barr Virus Volume 2. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-22834-1_5.

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Kieser, Arnd, and Kai R. Sterz. "The Latent Membrane Protein 1 (LMP1)." In Epstein Barr Virus Volume 2. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-22834-1_4.

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Vockerodt, Martina. "Epstein–Barr Virus Latent Membrane Protein 1." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_1979-2.

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Vockerodt, Martina. "Epstein–Barr Virus Latent Membrane Protein 1." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46875-3_1979.

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Vockerodt, Martina. "Epstein–Barr Virus Latent Membrane Protein 1." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_1979.

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Kikuchi, Shingo, Jocelyn Bédard, and Masato Nakai. "One- and Two-Dimensional Blue Native-PAGE and Immunodetection of Low-Abundance Chloroplast Membrane Protein Complexes." In Chloroplast Research in Arabidopsis. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-237-3_1.

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Kahn, Richard A. "The ARF subfamily." In Guidebook to the Sinall GTPases. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780198599456.003.0140.

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Abstract Unlike most of the members of the Ras superfamily, Arf was identified first as an activity and then as a distinct protein and only later as a family of structurally related proteins. As a result, many of the activities assigned to Arf can still only be ascribed to the subfamily (rather than one specific gene product) as the Arf prepared from mammalian sources is a mixture of several gene products. Earlier suggestions that distinct Arf proteins reside in membrane versus cytosol fractions have proven misleading. Rather, one of the more interesting features of Arf action in cells is the
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Gu, Feng, and Jean Gruenberg. "In vitro reconstitution of early to late endosome transport: biogenesis and subsequent fusion of transport intermediates." In Essential Cell Biology. Oxford University PressOxford, 2003. http://dx.doi.org/10.1093/oso/9780199638338.003.0008.

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Abstract Vesicles formed via invaginations of the plasma membrane are responsible for the internalization and turnover of cell surface proteins and lipids, and for the uptake of extracellular ligands and solutes. Although evidence is accumulating for the existence of more than one internalization pathway, most receptors are internalized via the well characterized clathrin-dependent pathway. The bulk of internalized molecules, including solutes, ligands, and membrane constituents, are then delivered to common early endosomes, at least in most animal cell types. From there, many receptors and li
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Mohammed Ali Jassim, Marwa, Majid Mohammed Mahmood, and Murtada Hafedh Hussein. "Human Herpetic Viruses and Immune Profiles." In Innate Immunity in Health and Disease. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96340.

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Herpesviruses are large, spherical, enveloped viral particles with linear double-stranded DNA genome. Herpesvirus virion consists of an icosahedral capsid containing viral DNA, surrounded by a protein layer called tegument, and enclosed by an envelope consisting of a lipid bilayer with various glycoproteins. Herpesviruses persist lifelong in their hosts after primary infection by establishing a latent infection interrupted recurrently by reactivations. The Herpesviridae family is divided into three subfamilies; α-herpesviruses, β-herpesviruses, and γ-herpesviruses based on the genome organizat
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Ali, Sikander, and Maria Najeeb. "Navigating the Endoplasmic Reticulum: New Insights and Emerging Concepts." In Updates on Endoplasmic Reticulum. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.105737.

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Endoplasmic reticulum (ER) is a membrane bound organelle adjacent to the nucleus in eukaryotic cells. It exists in the form of membranous sacs called “cisternae”. It was first discovered by Emilio Veratti in 1902 and later named as ‘Endoplasmic Reticulum’ in 1953 after visualization through electron microscopy. There are two types of endoplasmic reticulum based on the presence of ribosomes i.e., ‘rough’ ER and ‘smooth’ ER. Rough ER is the site for protein synthesis and modification by glycosylation. While the smooth ER is involved in the metabolism of lipids and carbohydrates. Recently, it has
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Streszczenia konferencji na temat "Latent membrane protein one"

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Korner, G., and Thorir D. Bjornsson. "INTRACELLULAR REGULATION OF TRANSGLUTAMINASE IN INTACT AND H202 INJURED CLONED BOVINE ENDOTHELIAL CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642863.

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Vascular endothelial cells are normally in a quiescent, nonproliferating state. After intimal injury, they are likely to undergo proliferation. We found that cloned bovine aortic endothelial cells (EC) in culture contain high activity of tissue-type transglutaminase (TG). The enzyme was Ca++ dependent, the Km and vmax for putrescine were 0.203 and 18.5 nmol/min/mg protein. Primary amines were capable of inhibiting its activity but not methylated dansylcadaverine. EC and TG molecular weight estimated by gel filtration or by SDS-PAGE, was 88±5,000 Kd. Immunologically it was cross-reactive with p
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Phillips, David R., Laurence A. Fitzgerald, Leslie V. Parise, and Israel F. Charo. "The Platelet Membrane Glycoprotein IIb-III a Complex: Member of a Superfamily of Adhesive Protein Receptors." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643727.

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The glycoprotein (GP) IIb-IIIa complex isthe receptor for fibrinogen,fibronectin and von Willebrand factor on the surface of activated platelets that mediates platelet aggregation.The GP IIb-IIIa complex contains two subunits; an a subunit, GP IIb, and a smaller 8 subunit, GP IIIa. To identify the subunits of GP IIb-IIIa responsible for fibrinogen binding, we examined the ability of purified subunitsto bind to immobilized fibrinogen. Both the GP IIb and the GP III a subunits have fibrinogen binding activity, suggesting that fibrinogen binds to multiple sites onthe GP I Ib-IIIa complex.A GP Ilb
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Koganti, Siva, Amanda De la Paz, Alexandra Freeman, Joyce Hui-Yuen, and Sumita Bhaduri-McIntosh. "Abstract A30: High levels of STAT3 and Epstein-Barr virus latent membrane protein 1 are required for virus-driven proliferation and transformation of B cells." In Abstracts: Second AACR International Conference on Frontiers in Basic Cancer Research--Sep 14-18, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.fbcr11-a30.

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"Emergence of SARS-CoV-2 Variant of Concern Omicron: Biological Features and Genomic Concern." In International Conference on Public Health and Humanitarian Action. International Federation of Medical Students' Associations - Jordan, 2022. http://dx.doi.org/10.56950/itrx2370.

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Abstract Corona virus infection is a worldwide health threat that has infected a substantial portion of the world's population and is caused by SARS-CoV-2. It is the natural tendency of a virus to change the genetic makeup through the point mutation, and such viruses are called the variant of the original virus. SARS-CoV-2 virus also undergoes such mutation (may be one or more and distinct from other) over time, and many genetically diverse variant has risen. Such variants might be of variants of concern (VOC) and variant of interest (VOI) based on the differences in virulence, transmissibilit
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THI, BUI, HO TA, LAO DUC, et al. "Non invasive detection of LMP 1 LMP 2 Epstein Barr Latent membrane protein load in the diagnosis of nasopharyngeal carcinoma in Vietnamese population based on nasopharyngeal brushing samples." In Fourth International Conference On Advances in Applied Science and Environmental Technology- ASET 2016. Institute of Research Engineers and Doctors, 2016. http://dx.doi.org/10.15224/978-1-63248-097-2-22.

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Maftouni, Negin, Mehriar Amininasab, MohammadReza Ejtehadi, and Farshad Kowsari. "Multiscale Molecular Dynamics Simulation of Nanobio Membrane in Interaction With Protein." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93054.

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One of the most important biological components is lipid nanobio membrane. The lipid membranes of alive cells and their mechanical properties play an important role in biophysical investigations. Some proteins affect the shape and properties of the nanobio membrane while interacting with it. In this study a multiscale approach is experienced: first a 100ns all atom (fine-grained) molecular dynamics simulation is done to investigate the binding of CTX A3, a protein from snake venom, to a phosphatidylcholine lipid bilayer, second, a 5 micro seconds coarse-grained molecular dynamics simulation is
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Ordónez-Saca, Brayan, Jordy Santana-Villamar, Martin Andersson, and Mayken Espinoza-Andaluz. "Unveiling the Kinetics of Accelerated Degradation in Polymer Electrolyte Fuel Cells." In ASME 2024 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2024. https://doi.org/10.1115/imece2024-145171.

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Abstract The polymer electrolyte fuel cells are electrochemical devices that can produce electricity, water, and heat through chemical reactions of hydrogen and oxygen. This manuscript focuses on one detailed state of degradation, called as Membrane Chemical Stability and Metrics. The Accelerated Stress Test under study was standardized by the Department of Energy. Recent advancements in the study of degradation are related to achieving three important objectives: increasing system specific power, reducing system cost, and improving system durability to make fuel cell technology more commercia
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SIMON, M. F., H. CHAP, and L. DOUSTE-BLAZY. "EFFECTS OF SIN 1 ON PLATELET ACTIVATION INDUCED BY THROMBIN IN HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643423.

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The mechanism of platelet activation is well known. The interaction of agonist such as thrombin, on specific membrane receptor induces phosphatidylinositol-specific phospholipase C activation, with a concomitant formation of two second messengers (from PIP2): inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 is able to induce a rapid discharge of Ca2+ from internal stores and Ca2+ influx through plasma membrane by unidentified Ca2+ channels linked to receptor activation. The increase of cytoplasmic free calcium concentration leads to the activation of the calcium calmodulin depe
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Geiser, Vicki M., Julie Girard, Mathias Godsil, Thomas Kahler, Emily Rausch, and Hayley Rutledge. "Abstract 560: Development of an organotypic raft culture system to study the role of latent membrane protein 1 during Epstein-Barr virus replication." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-560.

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Hsu, Cheng-Lung, Hsin-Pai Li, Yung-Chia Kuo, Ngan-Ming Tsang, and Yu-Sun Chang. "Abstract 1020: Latent membrane protein 1 N-C interaction of EBV facilitates (nuclear factor kappa-light-chain-enhancer of activated B cells transcriptional activity." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1020.

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Raporty organizacyjne na temat "Latent membrane protein one"

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Thongtan, Thananya, Poonlarp Cheepsunthorn, and Kiat Ruxrungtham. An analysis and studies expression of receptor molecule on microglia cells to inhibits infection of the cells from Japanese encephalitis virus : Research report (Year 2009). Chulalongkorn University, 2009. https://doi.org/10.58837/chula.res.2009.14.

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Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is a major cause of viral encephalitis in Asia. Even though the principle target cells for JEV in the central nervous system are neurons, the microglia is activated in response to JEV infection. This research aimed to investigate the relationship between JEV and microglial cells. The percentage of JEV infectivity in mouse microglial (BV-2) cell line at 8, 15 and 24 hr post infection was determined by flow cytometry. It was found that the percentage of infected cells were approximately 53.5, 71.3 and 83.6 respectively. The JEV bind
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Pimtanothai, Nattiya. Mapping cytotoxic T lymphocyte epitopes within latent membrane protein 1 from nasopharyngeal carcinoma-associated epstein-barr virus in Thai population. Thailand Research Fund, 2003. https://doi.org/10.58837/chula.res.2003.24.

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Zilberstein, Aviah, Bo Liu, and Einat Sadot. Studying the Involvement of the Linker Protein CWLP and its Homologue in Cytoskeleton-plasma Membrane-cell Wall Continuum and in Drought Tolerance. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7593387.bard.

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The study has been focused on proline-rich proteins from the HyPRP family. Three proline-rich proteins have been characterized with the CWLP as the main objective. We showed that this unique protein is assembled in the plasma membrane (PM) and forms a continuum between the cell wall (CW) and cytosol via the PM. While spanning the PM, it is arranged in lipid rafts as CWLP-aquaporin complexes that recruit PP2A-β”, as a part of PP2A enzyme, close to the aquaporin moiety where it dephosphorylates two crucial Ser residues and induces closure of the aquaporin water channels. The closure of water cha
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Blumwald, Eduardo, and Avi Sadka. Citric acid metabolism and mobilization in citrus fruit. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7587732.bard.

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Accumulation of citric acid is a major determinant of maturity and fruit quality in citrus. Many citrus varieties accumulate citric acid in concentrations that exceed market desires, reducing grower income and consumer satisfaction. Citrate is accumulated in the vacuole of the juice sac cell, a process that requires both metabolic changes and transport across cellular membranes, in particular, the mitochondrial and the vacuolar (tonoplast) membranes. Although the accumulation of citrate in the vacuoles of juice cells has been clearly demonstrated, the mechanisms for vacuolar citrate homeostasi
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Delmer, Deborah P., and Prem S. Chourey. The Importance of the Enzyme Sucrose Synthase for Cell Wall Synthesis in Plants. United States Department of Agriculture, 1994. http://dx.doi.org/10.32747/1994.7568771.bard.

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The goal of this work was to understand the role of the enzyme sucrose synthase (SuSy) in synthesis of cellulose and callose in plants. The work resulting from the this grant leads to a number of conclusions. SuSy clearly plays diverse roles in carbon metabolism. It can associate with the plasma membrane of cells undergoing rapid cellulose deposition, such as cotton fibers, developing maize endosperm, gravistimulated pulvini, and transfer cells of the cotton seed. It is also concentrated at sites of high callose deposition (tapetal cells; cell plates). When SuSy levels are lowered by mutation
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Elbaum, Michael, and Peter J. Christie. Type IV Secretion System of Agrobacterium tumefaciens: Components and Structures. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699848.bard.

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Objectives: The overall goal of the project was to build an ultrastructural model of the Agrobacterium tumefaciens type IV secretion system (T4SS) based on electron microscopy, genetics, and immunolocalization of its components. There were four original aims: Aim 1: Define the contributions of contact-dependent and -independent plant signals to formation of novel morphological changes at the A. tumefaciens polar membrane. Aim 2: Genetic basis for morphological changes at the A. tumefaciens polar membrane. Aim 3: Immuno-localization of VirB proteins Aim 4: Structural definition of the substrate
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Kirchhoff, Helmut, and Ziv Reich. Protection of the photosynthetic apparatus during desiccation in resurrection plants. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7699861.bard.

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In this project, we studied the photosynthetic apparatus during dehydration and rehydration of the homoiochlorophyllous resurrection plant Craterostigmapumilum (retains most of the photosynthetic components during desiccation). Resurrection plants have the remarkable capability to withstand desiccation, being able to revive after prolonged severe water deficit in a few days upon rehydration. Homoiochlorophyllous resurrection plants are very efficient in protecting the photosynthetic machinery against damage by reactive oxygen production under drought. The main purpose of this BARD project was
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Dubcovsky, Jorge, Tzion Fahima, and Ann Blechl. Molecular characterization and deployment of the high-temperature adult plant stripe rust resistance gene Yr36 from wheat. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699860.bard.

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Stripe rust, caused by Puccinia striiformis f. sp. tritici is one of the most destructive fungal diseases of wheat. Virulent races that appeared within the last decade caused drastic cuts in yields. The incorporation of genetic resistance against this pathogen is the most cost-effective and environmentally friendly solution to this problem. However, race specific seedling resistance genes provide only a temporary solution because fungal populations rapidly evolve to overcome this type of resistance. In contrast, high temperature adult plant (HTAP) resistance genes provide a broad spectrum resi
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Thanyasrisung, Panida, Aemvika Vittayaprasit, Voravee Hoven, Sugai, Motoyuki, and Oranart Matangkasombut. Rapid detection of mutans streptococci by substrate specific binding of automutanolysin : Final report. Faculty of Dentistry, Chulalongkorn University, 2016. https://doi.org/10.58837/chula.res.2016.19.

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Chair-side rapid detection of mutans streptococci is an important aid to clinical dental caries risk assessment. Rapid Streptococcus mutans detection tools are available on the market but there are a small number. Automutanolysin (Aml) is a peptidoglycan hydrolase whose cell wall-binding domain (CWBD) has substrate-specificity towards mutans streptococci. This study aims to develop a rapid detection assay using CWBD conjugated with horseradish peroxidase (HRP). However, the recombinant protein was as insoluble form. Therefore, magnetic nanoparticles were used as an alternative reporter to conj
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Rafaeli, Ada, Russell Jurenka, and Daniel Segal. Isolation, Purification and Sequence Determination of Pheromonotropic-Receptors. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7695850.bard.

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Moths constitute a major group of pest insects in agriculture. Pheromone blends are utilised by a variety of moth species to attract conspecific mates, which is under circadian control by the neurohormone, PBAN (pheromone-biosynthesis-activating neuropeptide). Our working hypothesis was that, since the emission of sex-pheromone is necessary to attract a mate, then failure to produce and emit pheromone is a potential strategy for manipulating adult moth behavior. The project aimed at identifying, characterising and determining the sequence of specific receptors responsible for the interaction w
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