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Data publikacji: 3 czerwca 2025

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1

Harder, Ulrike. "Amino acid analysis in biofluids using LC-MS/MS." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-166180.

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Klinische Studien zeigen, dass die Zusammensetzung von zirkulierenden, freien AS im Blut, ein Marker für monogene und multigenetische Krankheiten ist. Die Analyse von hohen Probandenzahlen in klinischen Studien wird oftmals durch aufwendige und lange Probenaufarbeitungsschritte begrenzt. Im Rahmen der Metabolomics Plattform, die im Dr. von Haunerschen Kinderspitals etabliert wurde, wurde eine Hochdurchsatzmethode entwickelt, die eine selektive, sensitive, präzise und robuste Quantifizierung von 22 AS aus kleinen Probenvolumina ermöglicht. Im Laufe der Zeit konnten noch weitere Aminosäuren zur

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2

Couchman, Lewis. "LC-MS/MS analysis of buprenorphine and norbuprenorphine in urine." Thesis, Queen Mary, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511397.

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Zhou, Bin. "Computational Analysis of LC-MS/MS Data for Metabolite Identification." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/36109.

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Metabolomics aims at the detection and quantitation of metabolites within a biological system. As the most direct representation of phenotypic changes, metabolomics is an important component in system biology research. Recent development on high-resolution, high-accuracy mass spectrometers enables the simultaneous study of hundreds or even thousands of metabolites in one experiment. Liquid chromatography-mass spectrometry (LC-MS) is a commonly used instrument for metabolomic studies due to its high sensitivity and broad coverage of metabolome. However, the identification of metabolites remains

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4

Bui, Thinh Quang. "ANALYSIS OFMERCURY THIOL COMPLEXESBY LC ICP-MS." Thesis, Umeå universitet, Kemiska institutionen, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-163383.

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5

Li, Huawen. "Quantitative Analysis of Bleomycin in Rat Plasma by LC-MS/MS." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1528851820162444.

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Silcocks, S. E. "Component analysis of natural products by Lc, Lc-Api-Ms, and Lc-Api-MSN techniques." Thesis, Swansea University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639034.

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Natural products provide a wide and virtually inexhaustible source of novel, useful, and often hard to synthesise compounds. However, due to the origin of these products, the matrices tend to be complex, and individual components are difficult to isolate and conclusively identify. The majority of this thesis focuses on the separation, identification, and quantification of certain species inherent within natural product samples. Liquid chromatography atmospheric pressure ionisation mass spectrometry techniques were utilised for this research. Chapter One provides a brief history and introductio

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7

Utami, Wahyu. "Ion pairing LC-MS/MS method for analysis of intracellular phosphorylated metabolites." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/30566/.

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Nucleoside analogues have been extensively used in medication. The nucleoside analogue cordycepin is the principal bioactive compound found in the caterpillar fungi (Cordyceps and Ophiocordyceps). It has been shown to have biological activity, including anti-inflammatory, immunomodulatory and anti-proliferative activity in many kinds of malignant cells. Intracellular drug interactions at the nucleotide level can be explained by understanding the intracellular metabolism of nucleoside analogues as well as their plasma metabolism since their efficacy of therapy or toxicity does not associate wit

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8

Kirk, John Daniel. "Particle beam LC/MS with fast atom bombardment." Thesis, Georgia Institute of Technology, 1990. http://hdl.handle.net/1853/27127.

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9

Yacoub, Kimberly. "Development of ESI-LC-MS Method for Drug Analysis." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1524040258129489.

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10

Bianchi, Michele. "LC-MS applications in Pharmaceutical Analysis, Bioanalysis and Proteomics." Doctoral thesis, Università del Piemonte Orientale, 2019. http://hdl.handle.net/11579/102458.

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Liquid Chromatography tandem Mass Spectrometry (LC-MS) is a powerful tool available to scientists with multidisciplinary applications. In this thesis, LC-MS technique had a key role to perform exciting experiments giving back an outstanding contribute to each project caught up. Different LC-MS instruments were involved. We worked with HPLC and UHPLC systems operating with micro- or nano-flow rates. At the same time, various MS analyzers working in different scan modes (full MS, MS2, MS3, SRM, MRM and DDA) were chosen depending by the expected results. The projects addressed by this thesis were

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11

Moura, Eliel Rogério Rolim de. "Determinação de pesticidas no Rio Piquiri por LC/MS/MS." Universidade Tecnológica Federal do Paraná, 2013. http://repositorio.utfpr.edu.br/jspui/handle/1/841.

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A qualidade da água e preservação dos ambientes aquáticos assumiu papel fundamental para a sustentabilidade, não só relacionado ao abastecimento, mas também à preservação destes ecossistemas. O uso da água, especialmente para abastecimento dos centros urbanos e irrigação na agricultura tem favorecido a tendência à diminuição das reservas de águas limpas e consequentemente a menor diluição de poluentes presentes, entre eles os pesticidas. Os pesticidas fazem parte do grupo de poluentes que podem gerar impactos significativos nos ambientes em que são inseridos, impactos dos quais alguns ainda nã

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12

Yousef, M. "Analysis of degradation products of drugs and dyes by LC-MS and SFC-MS." Thesis, Swansea University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636716.

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Chapter one introduces chromatography and mass spectrometry used to conduct experiments in this thesis. An explanation in the importance and ways of implementing the interfacing of high-pressure liquid chromatography and supercritical fluid chromatography with mass spectrometry is briefly summarized. The feasibility of high-pressure liquid chromatography and supercritical fluid chromatography mass spectrometry for the analysis of β-blockers is shown in chapter two. Methods were developed for the separation and analysis of various β-blockers using SFC and HPLC coupled to MS for specificity. The

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13

Li, Siwei. "High Throughput Automated Comparative Analysis of RNAs Using Isotope Labeling and LC-MS/MS." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384427990.

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14

BOLFI, BIANCA. "Target and non-target LC-MS/MS analysis of cosmetic, food and environmental samples." Doctoral thesis, Università del Piemonte Orientale, 2018. http://hdl.handle.net/11579/97187.

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15

Madugundu, Guru Swamy. "Analysis of radiation induced DNA damage by LC-MS/MS in isolated and cellular DNA." Thèse, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/9465.

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Abstract: It is well established that ionizing radiation induces a variety of damage in DNA by direct effects that are mediated by one-electron oxidation and indirect effects that are mediated by the reaction of water radiolysis products, e.g., hydroxyl radicals (•OH). In cellular DNA, direct and indirect effects appear to have about an equal effect toward DNA damage. We have shown that ϒ-(gamma) ray irradiation of aqueous solutions of DNA, during which •OH is the major damaging ROS can lead to the formation several lesions. On the other hand, the methylation and oxidative demethylation of cy

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16

Huang, Mian. "Analysis of distributions of bacteriochlorophyll derivatives using HPLC and LC-MS." Thesis, University of York, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534942.

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17

Tsai, Tsung-Heng. "Bayesian Alignment Model for Analysis of LC-MS-based Omic Data." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/64151.

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Liquid chromatography coupled with mass spectrometry (LC-MS) has been widely used in various omic studies for biomarker discovery. Appropriate LC-MS data preprocessing steps are needed to detect true differences between biological groups. Retention time alignment is one of the most important yet challenging preprocessing steps, in order to ensure that ion intensity measurements among multiple LC-MS runs are comparable. In this dissertation, we propose a Bayesian alignment model (BAM) for analysis of LC-MS data. BAM uses Markov chain Monte Carlo (MCMC) methods to draw inference on the model par

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18

Al-Asmari, Ahmed Ibrahim. "Applications of LC-MS/MS in forensic toxicology for the analysis of drugs and their metabolites." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/1290/.

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This thesis studied opioids and alcohol in forensic toxicology by LC-MS/MS, which avoids time-consuming procedures involving hydrolysis, extraction and derivatisation. Initially, a method was validated for quantification of opioids and unhydrolysed polar metabolites in autopsy specimens and was used to develop procedures for interpretation of forensic toxicology results. The LC-MS/MS method developed has been validated for the simultaneous determination of 24 opioids in human whole blood, including, for the first time in human whole blood, naloxone-3-glucuronide. Although a large number of dru

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19

Williams, L. D. "Analysis of pharmaceuticals and agrochemicals by LC-MS and SFC-MS using atmospheric pressure ionisation techniques." Thesis, Swansea University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636608.

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Chapter One involves a brief introduction to the different types of chromatography and mass spectrometry used in this thesis. A further explanation of the ionisation processes used and the interfaces for liquid chromatography and supercritical fluid chromatography coupling to mass spectrometry is provided. The basis of Chapter Two is the separation and analysis of various β-blockers using liquid chromatography-atmospheric pressure ionisation-mass spectrometry. Full analysis was conducted using an ion trap mass spectrometer. The advantages of using involatile phosphate buffers to effect separat

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20

Persson, Josefin. "Development and evaluation of methods for analysis of TBECH and HBCD using HRGC/HRMS and HPLC/MS/MS." Thesis, Örebro University, School of Science and Technology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-7695.

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<p>The two additive brominated flame retardants, tetrabromoethylcyclohexane (TBECH) and hexabromocyclododecane (HBCD) are used to prevent fire to start and spread. They are simply mixed with material and are most likely to leach out in the environment, because of non-covalently binding to the material. TBECH can exist as four pairs of enantiomers, α-, β-, γ- and δ-TBECH. The technical HBCD can exist as three pairs of enantiomers, α-, β- and γ-HBCD and two meso forms δ- and ε-HBCD. None of these compounds are produced in Sweden, but they are imported to industries. TBECH has been found in Belug

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21

Thüring, Kathrin Luise [Verfasser]. "Analysis of translationally active RNAs : quantification by microscale thermophoresis and modification analysis by LC-MS/MS / Kathrin Luise Thüring." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1123100837/34.

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Bishop, Michael Jason. "The Application of Weak-Anion Exchange Chromatography for the Analysis of Organic Zwitterions Using LC/MS/MS." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/chemistry_theses/5.

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A rapid and accurate quantitative method was developed and validated for the analysis of four urinary organic acids with nitrogen containing functional groups, formiminoglutamic acid (FIGLU), pyroglutamic acid (PYRGLU), 5-hydroxyindoleacetic acid (5-HIAA), and 2-methylhippuric acid (2-METHIP) by liquid chromatography tandem mass spectrometry (LC/MS/MS). The chromatography was developed using a weak anion-exchange amino column that provided mixed-mode retention of the analytes. The elution gradient relied on changes in mobile phase pH over a concave gradient, without the use of counter-ions or

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23

Hein, Renee Joy. "LC-MS analysis of related peptides and anions in the positive mode." [Ames, Iowa : Iowa State University], 2008.

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24

Nezami, Ranjbar Mohammad Rasoul. "Novel Preprocessing and Normalization Methods for Analysis of GC/LC-MS Data." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/73499.

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We introduce new methods for preprocessing and normalization of data acquired by gas/liquid chromatography coupled with mass spectrometry (GC/LC-MS). Normalization is desired prior to subsequent statistical analysis to adjust variabilities in ion intensities that are not caused by biological differences. There are different sources of experimental bias including variabilities in sample collection, sample storage, poor experimental design, noise, etc. Also, instrument variability in experiments involving a large number of runs leads to a significant drift in intensity measurements. We propose n

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25

Ida, Björs. "Development of separation method for analysis of oligonucleotides using LC-UV/MS." Thesis, Uppsala universitet, Analytisk farmaceutisk kemi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-403381.

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Introduction Oligonucleotides are short nucleic acid chains, usually 19-27mer long. They bind to their corresponding chain, making a specific inhibition possible. In pharmaceuticals, this can be used to inhibit the expression of a gene or protein of interest. Oligonucleotides are usually analyzed based on separation using both hydrophobic and ion-exchange properties. In this project, the possibility to use a mixed-mode column to separate these oligonucleotides and their impurities were explored. Method Liquid chromatography is used as the separation method and the method of detection is both m

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26

Minten, Johanna. "Development of methods for the analysis of polar compounds in environmental matrices using LC/UV and LC/MS /." Stockholm : Department of applied environmental science (ITM), Stockholm University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-29108.

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Diss. (sammanfattning) Stockholm : Stockholms universitet, 2009.<br>At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: Submitted. Paper 4: Submitted. Härtill 4 uppsatser.

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27

Eckberg, Melanie N. "Forensic Toxicological Screening and Confirmation of 800+ Novel Psychoactive Substances by LC-QTOF-MS and 2D-LC Analysis." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3923.

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Novel psychoactive substances (NPS) represent a great challenge to toxicologists due to the ability of illicit drug manufacturers to alter NPS chemical structures quickly and with ease to circumvent legislation regulating their use. Each time a new structure is introduced, there is a possibility that it has not been previously recorded in law enforcement or scientific databases. Many toxicology laboratories use targeted analytical methods that rely on libraries of known compounds to identify drugs in samples. However, these libraries do not include large numbers of NPS which could result in no

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Tang, Jennifer Huiqin. "DEVELOPMENT OF A LC/MS/MS ENZYME METHOD FOR N8 - ACETYLSPERMIDINE MEASUREMENTS IN ENZYME ASSAYS." Scholarly Commons, 2005. https://scholarlycommons.pacific.edu/uop_etds/607.

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This thesis describes the development of a way to study the N8 - acetylspermidine deacetylase enzyme activity. The method created in this thesis emphasizes sensitivity, accuracy and safety. In this study, HeLa cells were cultured and extracted to yield a crude N8 - acetylspermidine deacetylase enzyme mixture. By measuring the decrease of N8 - acetylspermidine and the increase of spetmidine, N8 -acetylspermidine deacetylase enzyme activity can be determined using either a Varian 1200L LC/MS/MS or an API 3000 LC-ES (+)/MS/MS. An acetylation-derivatization method was developed because N8 -acetyls

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Manza, Linda Lee. "Characterization of Protein Sumoylation in Response to Alkylation Stress in HEK 293 Cells." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/193944.

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Stress conditions such as heat shock, UV, alkylating agents, and H2O2 have been shown to result in the modification of a variety of protein targets via the production of reactive electrophiles. These modifications can directly impact protein function or can alter posttranslational modifications, thus leading to a disruption of cellular regulatory processes. Recent studies have shown that stress-induced protein modifications can modulate posttranslational modification by the small ubiquitin related modifier (SUMO) family of proteins. Unlike ubiquitination, which primarily targets proteins fo

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30

Bush, David Roy. "The LC/MS/MS Analysis of Pyridinoline and Desmosines in Hypertensive Mouse Aorta, Elucidation of Arginine and Proline Fragmentation for the Analysis of Arginine Metabolism in Mosquitoes by LC/MS/MS, and Mudpit Identification of B. Pseudomallei Proteins in Urine." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/293615.

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This dissertation presents an investigation into the application of mass spectrometry to the detection and quantitation of proteins and amino acids in complex biological samples. This is accomplished by two dimensional chromatography (strong cation exchange / reverse phase) coupled to tandem mass spectrometry followed by peptide spectrum matching for the detection of Burkholderia pseudomallei proteins in infected patient urine samples and reverse phase liquid chromatography coupled to a triple quadrupole and quadrupole time of flight mass spectrometers for the quantitation of cross-linked or

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31

Marques, Pereira M. L. "Analysis of pharmaceutical products and nucleotides by LC-MS and tandem mass spectrometry." Thesis, Swansea University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.638005.

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Tandem mass spectrometry and chromatographic techniques coupled with mass spectrometry are demonstrated to be extremely useful in independent investigations of biochemical and pharmacological compounds. The first chapter gives some insight into the theory behind the chromatographic and mass spectrometric techniques used. Cyclic nucleotides are vital components in biochemical signal transduction and regulation, and thus the enzymes which regulate their intracellular levels are of great interest as pharmacological targets. In chapter 2, fast atom bombardment - collision induced dissociation and

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32

Paulines, Mellie June. "Reference Maps for Comparative Analysis of RNA by LC-MS and RNA Sequencing." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1539079739684729.

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Dubber, Mary-Jean. "Application of CE, HPLC and LC-MS-MS for the analysis and quality control of Ginkgo biloba dosage forms." Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1003235.

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Natural products are complex mixtures of compounds with therapeutic effects which are often reported to be due to the synergistic action of multiple and sometimes unknown components. Consequently, standardization of these products is complex and a lack of effective quality control (QC) criteria in most countries has led to marketing of commercial products with questionable quality, safety and efficacy (QSE). The aim of this study was therefore to develop qualitative and quantitative analytical methods for use in the QC of Ginkgo biloba solid oral dosage forms. Initially, a micellar electrokine

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34

ZORZOLI, MARIA CHIARA. "AUTOMATION OF SAMPLE PRAPARATION IN BIOANALYTICS FOR HIGH-THROUGHPUT, ACCURATE LC-MS/MS ANALYSIS AND LABORATORY INFORMATION MANAGEMENT SYSTEM." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150037.

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Developing high-capacity sample preparation systems and strategies are of key importance in providing breakthrough in the time required to develop a drug by increasing the number/time of analyzed samples. This objective must be achieved without loosing quality within the obtained data and it is of paramount importance in Pharmacokinetic/dynamic studies. The aim of this PhD project in Analytical Chemistry is to automize the manual sample preparation processes for LC/MS analysis using high throughput techniques, and to insert the developed process in the frame of a pharmaceutical bioanalytical p

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Battaglia, Francesca. "Analysis of Allergenic Proteins by Mass Spectrometry." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425570.

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The general aim of the activities conducted in the framework of my PhD were to learn modern techniques for analyzing proteins by mass spectrometry (MS) and then to apply these techniques and approaches to the analysis of allergenic proteins contained in foods. My research activities were conducted at the Laboratory of Protein Chemistry of CRIBI, University of Padua, where previously I have conducted the research for my Thesis for the Doctor degree in Pharmaceutical Biotechnologies. During the fist year of my PhD I have concluded the Thesis project on the amyloid aggregation of -lactalbumin, a

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Petsalo, A. (Aleksanteri). "Development of LC/MS techniques for plant and drug metabolism studies." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514294419.

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Abstract Liquid chromatography (LC) combined with mass spectrometry (MS) is a powerful tool for qualitative and quantitative analytics of organic molecules from various matrices, and the use of this hyphenated technique is very common in bioanalytical laboratories. In this study, LC/MS methods and the required sample preparation applications were developed for plant flavonoid and drug metabolism studies. The main focus was in developing methods to be used during cytochrome P450 (CYP) -specific drug interaction studies. Traditional high performance liquid chromatography (HPLC) and new, more efﬁ

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Browne, Edward R. "Analysis of polar herbicides and steroids by LC-MS using atmospheric pressure ionisation techniques." Thesis, Swansea University, 2003. https://cronfa.swan.ac.uk/Record/cronfa42418.

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Chapter one is a brief introduction to solid phase extraction, chromatography and mass spectrometry. A further explanation of the ionisation processes and the interfaces used to allow for coupling of high performance liquid chromatography (HPLC) to mass spectrometry (MS) is provided. The basis of chapter two is the separation and analysis of polar herbicides. HPLC-MS was used to perform analysis of triazine, phenylurea and acidic herbicides. Solid phase extraction was investigated for the analysis of these herbicides in river water and analysis of real samples was conducted. Chapter three invo

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38

Ruotsalainen, Daniel. "Analysis of organic compounds in the rhizosphere soil of Cyperus rotundus using LC-MS." Thesis, KTH, Kemi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-291534.

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Den presenterade studien hade som syfte att utveckla en extraktions-, provpreparerings- och analysmetod för jorden, i vilken gräset Cyperus rotundus växer, i ett försök att identifiera möjliga äggläggningsattraherande ämnen för myggan Anopheles gambiae. Högupplösande vätskekromatografi med hydrofob stationär fas (RP-HPLC, en.) med Masspektrometri med Elektrosprejjonisering (ESI-MS, en.) användes för separation och detektion av de extraherade proverna. Ett flertal extraktionssatser gjordes, där parametrar och tekniker ändrades under utvecklingen av arbetet. Ultraljudsassisterad extraktion (UAE)

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Shi, Chunxiao. "New Protein Inhibitors and New LC-MS Approaches for the Analysis of Synthetic Copolymers." University of Akron / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=akron1353903282.

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Taylor, Stephen D. "In-line combination of LC with MS, NMR, UV and IR in drug analysis." Thesis, Sheffield Hallam University, 2007. http://shura.shu.ac.uk/20429/.

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Mass spectrometry (MS), nuclear magnetic resonance (NMR) spectrometry and Fourier transform infrared (FTIR) spectrometry have for many years been three of the analyst's main tools for the characterisation of unknown compounds. Their complementary nature is well known - NMR can provide unequivocal data for structural isomers (something not possible by mass spectrometry) while mass spectrometry and infrared can often identify moieties which lack a proton NMR resonance. For mixtures, high performance liquid chromatography (HPLC) coupled with any of these spectrometric techniques would provide a b

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41

Pompano, Joseph Michael. "Neural Networks in the Analysis of Water-Soluble Sulfonylurea Herbicides Using an LC/MS." VCU Scholars Compass, 1999. https://scholarscompass.vcu.edu/etd/5247.

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In this research, a hidden node pruning algorithm was developed for an artiﬁcial neural network (ANN) that automatically determined a more efﬁcient size of the hidden layer, caused the ANN to resize itself, and then continued to train using a standard back-propagation algorithm. The hidden-node pruning algorithm was based on determining the number of signiﬁcant eigenvalues present in the matrix of values produced by the hidden layer, starting with an excessive number of hidden nodes. Eight sulfonylurea herbicides were used as the target analytes in this study. The ability of an ANN to simplify

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42

Barclay, Victoria K. H. "Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices." Doctoral thesis, Uppsala universitet, Avdelningen för analytisk farmaceutisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171550.

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This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. A method was also developed for the achiral compounds, diazepam and nordiazepam. The LC-MS/MS methods were validated by the use of the isotope-labeled compounds. As these isotope-labe

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Wabuyele, Simuli Lindah. "DEVELOPMENT OF LC-MS/MS METHODS FOR QUANTITATIVE ANALYSIS OF PLANT-DERIVED ANTICANCER AGENT AND SYNTHETIC ESTROGEN IN COMPLEX MATRICES." Cleveland State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=csu1400262843.

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Hines, Jesse, Shujuan Tao, Ron Orlando, and Stacy D. Brown. "A Novel Experimental Scheme to Fully Separate Permethylated Glycans and Allow Online RP-LC-MS with Simplified ESI-MS Analysis." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/5289.

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Ohtani, Yuta. "Molecular breeding of functional spinaches rich in folate and betacyanin based on metabolome analysis." Kyoto University, 2020. http://hdl.handle.net/2433/253323.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第22487号<br>農博第2391号<br>新制||農||1076(附属図書館)<br>学位論文||R2||N5267(農学部図書室)<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田充美, 教授梅澤俊明, 教授栗原達夫<br>学位規則第4条第1項該当

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Hribar, James Anthony. "Capillary Gradient Chromatofocusing-Mass Spectrometry: A Sensitive Approach for Protein Analysis." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1306436593.

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Yu, Qianqian. "Configuration, optimization and evaluation of a novel instrumental platform for automated SPE-LC-MS/MS analysis of drugs in whole blood." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-158151.

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The thesis describes the configuration, optimization and evaluation of a novel instrumental platform for fully automated SPE-LC-MS/MS analysis of small molecules, such as drugs, in whole blood. The immunosuppressant Cyclosporine A was chosen as a model analyte, as this drug is predominantly bound to erythrocytes. First, anticoagulated blood is converted into so-called Cell-Disintegrated Blood (CDB) by heat-shock or cryogenic treatment. CDB represents a homogenous blood sample and consists of subcellular particles which do not sediment on standing and do not clog capillaries, sieves or HPLC

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Keller, Sarah [Verfasser]. "GC/MS- and LC/MS-based metabolic and proteomic analysis of dysferlin-deficient muscle from patients and animal models / Sarah Keller." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2014. http://d-nb.info/1046563718/34.

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Battah, Abdel-Kader Hamdi. "The analysis of drugs and solvents in forensic toxicology by combined GC- and LC-MS." Thesis, University of Glasgow, 1989. http://theses.gla.ac.uk/4115/.

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The work described in this thesis was in the field of Forensic Toxicology, which is the study and practice of toxicology for legal purposes. Three different application areas were considered: (a) the analysis of drugs in blood by gas chromatography-mass spectrometry (GC-MS) following isolation from the biological matrix by solid phase extraction procedures, (b) the analysis of paint solvents in blood by gas chromatography (GC) and GC-MS following dynamic headspace elution from blood, and (c) an evaluation of Thermospray/Plasmaspray (TSP/PSP LC-MS) liquid chromatography-mass spectrometry as the

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Jabłonka-Salach, Katarzyna. "Opracowanie specyficznych procedur spektralnych poszukiwania wskaźników wybranych jednostek chorobowych w próbkach klinicznych." Doctoral thesis, 2016. https://depotuw.ceon.pl/handle/item/1652.

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Wyniki pomiarów chemicznych są wykorzystywane w wielu obszarach, między innymi: w przemyśle, przy ocenie składu surowców, półproduktów i produktów czy w kontroli zanieczyszczeń środowiska. Analiza chemiczna jest również doskonałym narzędziem wspomagającym poszukiwania surowców geologicznych, badania materiałów związanych z rozwojem atomistyki czy badania związane z dziedzictwem kulturowym. Warto podkreślić, że ogromny rozwój technik pomiarowych w dziedzinie analizy chemicznej jaki nastąpił w XX wieku, przyczynił się do dużego zainteresowania ich zastosowaniem w badaniach medycznych. Z jednej s

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