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Rozprawy doktorskie na temat „Legionnaires' disease”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

De, Goveia C. "Legionella infections : a review of the literature and a prospective serological study of the incidence of Legionnaires disease at Groote Schuur Hospital." Master's thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/25585.

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A prospective study of patients with pneumonia admitted to Groote Schuur Hospital took place over a one-year period in an attempt to assess the incidence of legionella pneumonia. Acute and convalescent serum samples were obtained from 113 patients. Eight patients (7,1%) showed a fourfold rise in antibody titre against Legionella pneumophila group 1 antigen by indirect immunofluorescent test (IFAT). The findings suggest that legionella pneumonia, although not common, should be considered in the aetiology of pneumonia at Groote Schuur Hospital. The results are presented and a review of the liter

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IJzerman, E. P. F. "Progress in diagnostics and prevention of Legionnaires' disease." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2009. http://irs.ub.rug.nl/ppn/315954442.

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Doyle, Robyn Michelle. "Molecular analysis of Legionella longbeachae serogroup 1 virulence." Title page, contents and summary only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phd7546.pdf.

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Bibliography: leaves 246-304. Describes experiments aimed at characterising the potential virilant factors of Legionella longbeachae sg 1, an important human pathogen which is responsible for nearly half of all clinical cases of Legionella related pneumonia reported each year.

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Sakamoto, Ryota. "Is driving a car a risk for Legionnaires' disease?" Kyoto University, 2009. http://hdl.handle.net/2433/126450.

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Bhopal, Rajinder Singh. "Geographic variation in the incidence of Legionnaires' disease in Scotland." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/26329.

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The major sources of infection for Legionnaire's Disease, identified by study of outbreaks, are hot water systems and cooling towers. However, most cases are not part of outbreaks and, for these, the source of infection is rarely traced. The principal aim of this study was to help understand the source of non-outbreak infection by examining the epidemiology of the disease in Scotland. Of the recognized cases which met the study case-definition, 366 were ill between 1978 to 1986 giving a mean annual incidence rate of 7.9 per million. The annual incidence varied in Scotland (range 3.1 to 20.2) a

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Fry, Norman Kenneth. "Analysis of the ribosomal RNA genes of the family Legionellaceae for classification and identification." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315280.

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Boswell, Timothy Charles John. "The serological crossreaction between legionella and campylobacter." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267616.

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Wilmot, Peter Nicholas. "Modelling cooling tower risk for Legionnaires' Disease using Bayesian Networks and Geographic Information Systems." Title page, contents and conclusion only, 1999. http://web4.library.adelaide.edu.au/theses/09SIS.M/09sismw744.pdf.

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Includes bibliographical references (leaves 115-120) Establishes a Bayesian Belief Network (BBN) to model uncertainty of aerosols released from cooling towers and Geographic Information Systems (GIS) to create a wind dispersal model and identify potential cooling towers as the source of infection. Demonstrates the use of GIS and BBN in environmental epidemiology and the power of spatial information in the area of health.

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James, Brian William. "Nutrient availability modulating physiology and pathogenicity of Legionella pneumophila." Thesis, Open University, 1997. http://oro.open.ac.uk/57693/.

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A virulent strain of Legionella pneumophila serogroup 1 was established in continuous culture under defined iron-replete conditions at pH 6.9. Iron-limitation and extremes of pH (6.0 and 7.8) influenced the growth and metabolism of L. pneumophila, as manifested by increased metabolic activity, impaired energy coupling, and altered metabolic fluxes. In particular, the physiological versatility of L. pneumophila was demonstrated by a significant decrease in the iron content of biomass (6-fold increase in Yiron), coupled with reduced metabolic efficiency (Y, on), in response to iron-limited growt

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10

Ricketts, Katherine. "The influence of environmental factors on sporadic cases of Legionnaires disease in England and Wales." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549779.

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Mentasti, M. "Implementation of molecular techniques in the diagnosis of Legionnaires' disease and in the investigation of legionella outbreaks." Thesis, University of Westminster, 2016. https://westminsterresearch.westminster.ac.uk/item/9z94y/implementation-of-molecular-techniques-in-the-diagnosis-of-legionnaires-disease-and-in-the-investigation-of-legionella-outbreaks.

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Background. Legionnaires’ Disease (LD) is a mild to severe, potentially lethal, respiratory syndrome caused by members of the Legionella genus, in particular L. pneumophila serogroup (sg) 1 alone causes about 95% of culture confirmed cases. The infection is usually acquired by inhalation of aerosols originating from contaminated fresh water sources, consequently typing of both clinical and environmental isolates is crucial to rapidly identify the possible source and prevent further cases. Legionellae are difficult to isolate by culture, moreover as respiratory samples are not available for up

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12

Ko, Chi-mei. "Interaction of Legionella Pneumophila and selected algae and response to disinfectants." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc798089/.

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Two species of cyanobacteria (Fischeralla sp. 29161 and Phormidium autumnale) and one species of green algae (Fritschiella tuberosa) were found to promote survival of Legionella pneumophila in mineral salts medium cocultures. During the early stage of incubation Fischerella sp. supported growth of Legionella pneumophila even though the bacteria would not grow in the algae-free basal medium.

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Eriksson, Rebecca. "Legionella i kyltorn : Enkätundersökning gällande kommuners och länsstyrelsers tillsyn på kyltorn och behovet av ökad prioritering." Thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-153228.

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If cooling towers are poorly maintained there is a risk of microbial growth such as Legionella which in turn might spread via aerosols and infect humans. This may lead to an outbreak of legionnaires’ disease. The purpose of this study was to highlight the risks of Legionella and cooling towers along with investigating the legal responsibility of businesses and supervision authorities in this regard. The study also investigated whether business should be obligated to register their cooling towers at supervising authorities. The study was partly based on a survey which was sent to Sweden’s 290 m

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14

Simmering, Jacob Edward. "Seasonality, local weather and infectious disease: effects of heat and humidity on local risk for urinary tract infections and Legionella pneumonia." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/5852.

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Seasonality, or a cycling of high and low incidence, of infectious diseases has long been recognized but remains little understood. For many diseases, even major ones such as influenza, our knowledge of the seasonal drivers is very limited. One proposed driver of seasonality for many diseases is weather, especially temperature and humidity. I studied how likely an admission to a hospital was to be diagnosed with a UTI or pneumonia caused by Legionella across the US under various climates and weather conditions. I found that patients were 10–20% more likely to have a UTI when the monthly mean t

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15

Bernander, Sverker. "Detection and epidemiologic subtyping of Legionella pneumophila using DNA-based molecular methods /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-745-2.

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16

Chedid, Maria Bernadete Fernandes. "Incidência de infecção por Legionella pneumophila em pacientes que internaram no HCPA com pneumonia adquirida na comunidade." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2002. http://hdl.handle.net/10183/3761.

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Introdução: O diagnóstico microbiológico da infecção por Legionella é complexo, pois a bactéria não é visualizada à coloração de Gram no escarro, e sua cultura não é realizada na maioria dos laboratórios clínicos. A imunofluorescência direta nas secreções respiratórias tem baixa sensibilidade, em torno de 40% e a técnica da “PCR” não é ainda recomendada para o diagnóstico clínico (CDC, 1997). A detecção de anticorpos no soro é a técnica mais utilizada, e o critério definitivo é a soroconversão para no mínimo 1:128, cuja sensibilidade é de 70 a 80% (Edelstein, 1993). Como critérios diagnósticos

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17

Wilén, Charlotte. "Optimization of a method for detection of Legionella pneumophila in water samples." Thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450384.

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Legionella pneumophila is a bacterium which can be found in fresh water and causes Legionnaires’ disease, which can be deadly for humans depending on the condition of the infected individual. The bacterium is a gram-negative rod and can withstand severe conditions such as high temperature. Therefore, various treatments including heat and acid treatment are performed on the water to inhibit interfering microorganisms. However, to examine a larger volume of water, the water needs to pass through a filter, which can be very time consuming, and there are various variables that have a negative impa

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18

Manin, Graziele Zenaro. "Identificação dos componentes do Sistema Imune que participam na resistência de camundongos em modelo de infecção letal por Legionella longbeachae." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-21052014-153321/.

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A doença dos legionários consiste em uma broncopneumonia severa e atípica, que acomete de 2 a 7% das pessoas infectadas com Legionella spp e que apresenta taxa de mortalidade que varia de 5 a 30%, sendo considerada uma importante causa de morbidade e mortalidade mundial. A patologia causada pela espécie L. pneumophila tem sido amplamente estudada em modelos experimentais e suas características clínicas foram extensivamente descritas. No entanto, este modelo não representa adequadamente a doença que acomete seres humanos, pois L. pneumophila não é letal aos camundongos como é para humanos. Rece

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19

Ruiz-Moreno, Juan Sebastián [Verfasser]. "The hypomorphic HAQ variant of STING affects cGAS-dependent cytokine expression in response to bacterial infection and is associated with susceptibility to Legionnaires’ disease in humans / Juan Sebastián Ruiz-Moreno." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1204429006/34.

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Quirino, João Pedro Rodrigues de Sousa. "Doença dos legionários: uma revisão crítica." Bachelor's thesis, [s.n.], 2011. http://hdl.handle.net/10284/2455.

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Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para a obtenção do grau de Licenciado em Ciências Farmacêuticas<br>A Doença dos Legionários é uma forma de pneumonia atípica causada pela bactéria Legionella pneumophila. O período de incubação é de dois a dez dias, após o que surge uma pneumonia multifocal necrotizante com a formação de microabcessos. Os sintomas incluem, febre, tremores, tosse seca e dores de cabeça. As Legionellas encontram-se frequentemente em reservatórios de água e crescem em água quente. Os sistemas de distribuição de água e reservatório

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21

Peter, Aji. "Novel approaches for risk management of Legionella bacteria in domestic water systems." Thesis, Brunel University, 2018. http://bura.brunel.ac.uk/handle/2438/17140.

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Legionella pneumophila, the causative agent of Legionnaires' disease, is a water born pathogenic bacteria commonly found in natural and manmade water systems such as rivers, lakes, wet soil, hot and cold water storage systems (being able to survive at temperatures between 6-63 °C, and proliferating between 20-45 °C), showerheads, cooling towers and spa pools. The main pathway of exposure to Legionella is by inhaling the aerosols containing the microorganism. Legionnaires' disease can be fatal if not diagnosed and treated at the right time. Practical Legionella control starts with a risk assess

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22

Al-Dahlawi, Alia M. A. "Interaction of legionnaire's disease bacterium with human dendritic cells." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418292.

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Scaife, Helena Rachel. "The influence of phenotype on the stress resistance of Legionella pneumophila." Thesis, Sheffield Hallam University, 1999. http://shura.shu.ac.uk/20334/.

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Legionella pneumophila, the causative agent of Legionnaires' disease, is an aquatic intracellular organism capable of replicating within both amoebae and human phagocytic cells. A comprehensive study has been undertaken to examine the hypothesis that intracellular replication of L. pneumophila induces enhanced resistance to external stress stimuli relative to that of in vitro grown legionellae. Microscopical studies have shown that L. pneumophila grown in YE broth consistently develop a rod-shaped morphology and are non-motile. In contrast, L. pneumophila grown within Acanthamoeba polyphaga or

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Chang, Po-hsun. "Attachment of Legionella pneumophila to cells in vitro." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc798334/.

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The attachment and/or penetration of animal cells by two strains of Legionella pneumophila was studied in three vertebrae cell lines in vitro . The study focused on (1) differences in attachment and penetration between the two bacterial strains (an environmental isolate, Johannesburg-2, and a clinical isolate, Chicago-8) and between the cell lines (Hep-2, WI-38 and a murine line); (2) effects of L. pneumophila on cell morphology and growth; and (3) the effects of pyruvate and six sugars or sugar derivatives (D-mannose, D-Galactose, D-Glucose, L-glucose, D-fructose, and 2-deoxy-D-glucose).

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Ahanotu, Ejemihu Ndu. "Immune Response of the Rat to Outer Membrane Proteins of Legionella pneumophila." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc935780/.

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Outer membrane proteins (OMPs) were recovered from eleven strains (eight serogroups) of Legionella pneumophila by sequential treatment with Tris buffer (pH 8), citrate buffer(pH 2.75) and Tris buffer (pH 8). Transmission electron microscopy revealed clearly the separation of the outer membrane from the bacteria. The development of delayed hypersensitivity was also noted by measuring the area of arythema and induration produced by intradermal injections of the MPSs from Chicago 8 strain. The adjuvants enhanced greatly both active and cell-meditated immunity (CMI). Transient lymphocytopenia with

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26

Myers, Jessica Mae. "Isolation of Legionella Pneumophila From Well-Maintained Emergency Showers and Eyewash Stations." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1456.

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Legionella pneumophila is a gram-negative bacterium responsible for Legionnaire's disease, and is commonly transmitted via aerosolized water. Legionella colonization of emergency eyewash and shower stations may pose an exposure hazard to users of these stations. There is little information about the role of these stations as significant reservoirs for Legionella. Samples were collected from 67 stations in an industrial facility. At the time of this study, the stations within this facility were under a routine maintenance program that included at least monthly flushing. This study also included

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Almeida, Dejanira Alexandra de. "Interventions for preventing hospital-acquired legionnaires' disease." Master's thesis, 2013. http://hdl.handle.net/10400.14/14789.

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Background Legionnaires’ Disease (LD) has been recognized as a significant source of morbidity and mortality in many hospitals worldwide. Legionella in the hospital water distribution system has been epidemiologically linked to hospital-acquired LD. Despite the several disinfection methods available the optimal method to control hospital-acquired LD has not been established yet. Objectives To assess the efficacy of interventions for preventing hospital-acquired LD in hospitalized patients at high risk of developing the disease and the effect on environmental colonization associated to the r

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Santos, Elisabete Cristovam. "Accuracy of diagnostic tests for legionnaires' disease." Master's thesis, 2013. http://hdl.handle.net/10400.14/14791.

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Background Legionellosis are infections caused by Legionella spp. The diagnosis of high-risk patients should rely on microbiological tests which allow the establishment of this infection etiology. Cases have to be confirmed through the available diagnostic methods which have different performances, sensitivity, specificity, error causes, limitations, and needs of careful interpretation. Objectives Assess the accuracy of urinary antigen detection, direct fluorescent antibody (DFA) staining, serological testing, Protein Chain Reaction (PCR) versus culture (reference standard), in patients sus

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Hsieh, Hung-An, and 謝宏安. "Survey on the Legionnaires''disease knowledge, attitude and behavior of hospital staffs." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/13693697779089501112.

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碩士<br>國立中興大學<br>環境工程學系所<br>101<br>This study is to investigate the knowledge, attitude and behavior of Legionnaires''disease for staffs working in environmental safety health department, infective control department and other relevant units of six hospitals in central Taiwan. In total of 400 questionnaires, 360 were returned, and fill out answers not completely questionnaire as invalid questionnaires, we finally have 341 valid questionnaires, and the effective rate was 85.3%. We use Legionnaires'' disease Attitude Scale internal consistency analyze(criterion of internal con

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"Disinfection of Legionella pneumophila by photocatalytic oxidation." 2005. http://library.cuhk.edu.hk/record=b5892344.

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Cheng Yee Wan.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 95-112).<br>Abstracts in English and Chinese.<br>Acknowledgements --- p.i<br>Abstract --- p.ii<br>Table of Contents --- p.vi<br>List of Figures --- p.xi<br>List of Plates --- p.xiv<br>List of Tables --- p.xvi<br>Abbreviations --- p.xviii<br>Chapter 1. --- Introduction --- p.1<br>Chapter 1.1 --- Legionella pneumophila --- p.1<br>Chapter 1.1.1 --- Bacterial morphology and ultrastructure --- p.2<br>Chapter 1.1.2 --- Microbial ecology and natural habitats --- p.4<br>

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Yi-Chun, Lin, and 林怡君. "Surveillance of Legionella Colonization in Public Drinking Water System in Kaohsiung - Implication to Travel-Associated Legionnaires' Disease." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/17360181391817697515.

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碩士<br>高雄師範大學<br>環境教育研究所<br>98<br>Many recent studies suggested that Legionella present in drinking water systems may be the major source for outbreaks of community-acquired Legionnaires disease (LD), especially in travel-associated LDs. Numerous reports and national guidelines have recommended routine environmental cultures for Legionella in cruises, hotels, convention centers, and public buildings. The World Game held in Kaohsiung during summer 2009 drew attention of the public and media whether the water supply in Kaohsiung was contaminated by Legionella given the previously detected hospita

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Chien, Shang-Tao, and 錢尚道. "Apply the concepts of evidence-based medicine to develop the risk management strategy in hospital-acquired legionnaires’ disease." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/fp4yc6.

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碩士<br>國立中山大學<br>高階經營碩士班<br>96<br>Hospital-acquired Legionnaires’ Disease (LD) is a bacterial pneumonia caused by the genus of Legionella. It is an opportunistic pathogen with the characteristic of widespread distribution in the environment. Its source of infection associates with potable water systems. Proactively culturing hospital water supply for Legionella as a strategy for prevention of nosocomial LD has been widely adopted in other countries. Nosocomial LDs has been hardly reported in Taiwan. In addition, environmental cultures of Legionella in potable water systems in hospitals have no

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Chasqueira, Maria de Jesus Fernandes. "Doença dos legionários : estudo da diversidade de isolados de legionella obtidos em Portugal, 1987-2016." Doctoral thesis, 2017. http://hdl.handle.net/10362/22302.

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RESUMO: O trabalho desenvolvido dividiu-se em duas áreas do conhecimento do género Legionella: a epidemiologia e a interação bactéria-hospedeiro natural. Estudou-se a epidemiologia da Doença dos Legionários em Portugal, no período entre 1987 e 2016, analisando 205 isolados, 178 dos quais recuperados de doentes com formas graves de pneumonia e 27 de amostras ambientais. Entre os isolados clínicos, 130 foram enviados através do Programa de Vigilância Epidemiológica Integrada da Doença dos Legionários e 48 foram recuperados num hospital da área de Lisboa, com vários casos de infeção hospitalar du

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Cutcher, Zoe. "Applied Epidemiology in Victoria." Master's thesis, 2016. http://hdl.handle.net/1885/110519.

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The Health Protection Branch of the Victorian Government Department of Health and Human Services monitors and responds to incidents that could adversely affect the health of Victorians. During 2014-2015, I completed a field placement with the branch, assisting with numerous public health investigations and responses. In doing so I fulfilled the requirements of the Master of Philosophy in Applied Epidemiology (MAE). The skills I gained are demonstrated in this thesis. Evaluation of a public health surveillance system is a core requirement for the MAE

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Marques, Armando Hugo Soares. "Desenvolvimento na produção de proteínas recombinantes e respectivos anticorpos com interesse de diagnóstico e/ou terapêutico através de um novo sistema de fusão em Escherichia coli." Master's thesis, 2011. http://hdl.handle.net/1822/19909.

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Dissertação de mestrado integrado em Engenharia Biomédica (área de especialização em Engenharia Clínica)<br>A Pal é uma lipoproteina que existe em maior abundância na parede celular da Legionella pneumophila. A localização e abundância da Pal tornam-na um antigénio importante no controlo de infecções causadas por este microrganismo. A obtenção desta proteína na sua estrutura nativa é, assim, importante para a produção de anticorpos que possam ser utilizados em testes de diagnóstico rápidos e na produção de vacinas. Tendo em conta o potencial de diagnóstico da Pal bem como a necessidade de

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