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Artykuły w czasopismach na temat „Lemon Hill (Philadelphia, Pa.)”

Autor: Grafiati

Data publikacji: 29 lipca 2024

Data aktualizacji: 31 lipca 2025

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1

Ice, Gillian H. "Proceedings of the Human Biology Association 32nd Annual Meeting, March 29, 2007, Sheraton Society Hill, Philadelphia, PA." American Journal of Human Biology 20, no. 2 (2008): 242–48. http://dx.doi.org/10.1002/ajhb.20761.

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Ruiz, Victor M., Lindsay Hill, Manasa Gadde, Christopher Bulow, Maurizio Morri, and Nicholas Goldner. "Abstract B030: Using the ResCu system for preclinical testing of KRAS G12C inhibitors." Molecular Cancer Research 21, no. 5_Supplement (2023): B030. http://dx.doi.org/10.1158/1557-3125.ras23-b030.

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Abstract Introduction: Recent colorectal cancer trials with KRAS G12C inhibitors have faced resistance challenges, and a preclinical model is needed to test resistance inhibition strategies. Experimental Methods: We have developed a novel culturing system, ResCu, that allows for long-term culture of cells without the need for passaging, enabling us to determine treatment resistance that can develop over time in a physiologically relevant system that conserves the resistance pathways found in patients. Using this system, we evolved resistance to a KRAS G12C inhibitor, sotorasib, after only two

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Anderson, Ashley, Tate Bertea, James Neiswender, et al. "Abstract B014: Charting ovarian cancer dependencies with patient-derived organoids." Cancer Research 84, no. 5_Supplement_2 (2024): B014. http://dx.doi.org/10.1158/1538-7445.ovarian23-b014.

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Abstract The Cancer Dependency Map aims to accelerate precision cancer medicine by identifying the landscape of cancer vulnerabilities across all tumors. To address underrepresented cancer types, we have optimized a genome-wide CRISPR KO screening pipeline, utilizing a condensed Cas12a library, for patient-derived 3D models. Here, we present characterization of a cohort of ovarian models which consist of underrepresented cancer subtypes along with treatment-resistant cancers. In particular, our organoid dataset includes low-grade serous carcinoma models, an ovarian cancer subtype that is under

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Xiao, Weikun, Chae-Young Eun, Weian Zhao, and Reginald Hill. "Abstract 5848: Identification of mechanosensitive cancer associated fibroblasts in pancreatic cancer." Cancer Research 83, no. 7_Supplement (2023): 5848. http://dx.doi.org/10.1158/1538-7445.am2023-5848.

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Abstract The purpose of this study is to investigate whether a subpopulation of cancer associated fibroblasts (CAFs) are responsible for mechanosensation-mediated chemoresistance in pancreatic adenocarcinoma (PDAC). PDAC is one of the most lethal types of cancer with few effective treatments. The abundant stromal cells and the stiff desmoplastic microenvironment constitute more than 90% of the primary tumor bulk. However, there are few easily tunable models to recapitulate this stiff microenvironment. To address this issue, we have developed a Matrigel-based, orthogonally tunable 3-dimensional

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Oberholtzer, Nathaniel, Paramita Chakraborty, Mohamed Faisal Kassir, et al. "Abstract LB343: Golgihi T cells exhibit reduced susceptibility to exhaustion and improved tumor control." Cancer Research 84, no. 7_Supplement (2024): LB343. http://dx.doi.org/10.1158/1538-7445.am2024-lb343.

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Abstract The role of tumor microenvironment mediated disruption of Golgi architecture and function,termed Golgi stress, in the regulation of T cell survival and function are largely unknown. Here weshow that the disruption of Golgi architecture, identified by the decreased expression of GM130,was reverted upon treatment with hydrogen sulfide (H2S) donor GYY4137, or over-expressingcystathionine β-synthase (Cbs), an enzyme involved in the biosynthesis of endogenous H2S -that promoted stemness, antioxidant capacity and exhibited increased protein translationmediated in part by ER-Golgi shuttling

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Tang, Fanying, Duo Xu, Shangqian Wang, et al. "Abstract B026: Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets." Cancer Research 82, no. 23_Supplement_2 (2022): B026. http://dx.doi.org/10.1158/1538-7445.cancepi22-b026.

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Abstract In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR) dependence leads to clinically aggressive tumors with few therapeutic options. We used ATAC-seq (assay for transposase-accessible chromatin sequencing), RNA-seq, and DNA sequencing to investigate 22 organoids, six patient-derived xenografts, and 12 cell lines. We identified the well-characterized AR-dependent and neuroendocrine subtypes, as well as two AR-negative/low groups: a Wnt-dependent subtype, and a stem cell–like (SCL) subtype driven by activator protein–1 (AP-1) transcription factors. We used t

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Hill, Breana, Ioana Bondre, H. Meryem Soylu, et al. "Abstract B024: Maintenance therapy inhibition of ptk2 yields decreased disease in preclinical HRP/HRD models of recurrent HGSOC." Cancer Research 84, no. 5_Supplement_2 (2024): B024. http://dx.doi.org/10.1158/1538-7445.ovarian23-b024.

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Abstract High grade serous ovarian cancer remains the most lethal of the gynecologic malignancies, in part, because of the high incidence of recalcitrant and rapidly recurring disease. Disease recurrence is now better controlled due to maintenance therapy with PARP inhibitors, particularly in homologous repair deficient tumors. Efficacy in homologous repair proficient tumors represents an unmet need. We previously demonstrated that inhibitors of protein tyrosine kinase 2 (ptk2), a gene that is frequently gained in HGSOC, compromises the expression of tumor repair genes, decreases stemness, and

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Hill, Katherine A., Cynthia M. Pérez, Adriana Pons, et al. "Abstract C130: Cervical, breast, and colorectal cancer screening by COVID-19 booster and influenza vaccination status in a sample of women in Puerto Rico." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (2023): C130. http://dx.doi.org/10.1158/1538-7755.disp22-c130.

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Abstract Background: Recommendation by a healthcare provider is essential for women to seek preventative cancer screening. Research has shown patients are receptive to information about cancer screening given by health professionals administering influenza vaccines. Promotion of cancer screening during vaccination may be particularly important in Puerto Rico (PR), which, relative to the continental United States, has low cervical and colorectal cancer screening rates. Objective: This study aims to determine if receiving the influenza vaccine in the past year or ever receiving the COVID-19 boos

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Culp-Hill, Rachel, Collin Hill, Adele Blackler, and William Ricketts. "Abstract 2447: Identification of tumor marker gangliosides for early cancer detection: A mass spectrometry approach." Cancer Research 84, no. 6_Supplement (2024): 2447. http://dx.doi.org/10.1158/1538-7445.am2024-2447.

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Abstract Tumor-marker gangliosides (TMGs) have enormous potential for early-stage cancer detection as diagnostic biomarkers despite being relatively understudied in this context. AOA Dx is focused on the development of a mass spectrometry platform for the quantitation of TMGs in human serum, particularly disialogangliosides GD2 and GD3. The development of a mass spectrometry platform for TMG quantitation may allow for the identification of diagnostic signatures for early-stage cancer detection. Briefly, we monitored fragment moieties characteristic of gangliosides in an untargeted fashion by m

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Brown, Edward, Danielle Desa, Robert M. Brown, Edward B. Brown, Robert L. Hill, and Bradley M. Turner. "Abstract P5-06-13: Second-harmonic generation imaging reveals neoadjuvant chemotherapy-induced changes in breast tumor collagen." Cancer Research 82, no. 4_Supplement (2022): P5–06–13—P5–06–13. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-06-13.

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Abstract Breast cancer is the most common invasive cancer in women, with most deaths attributed to metastases. Neoadjuvant chemotherapy (NACT) may be prescribed prior to surgical removal of the tumor for subsets of breast cancer patients but can have diverse undesired and off-target effects including increased appearance of the ‘tumor microenvironment of metastasis’ or TMEMs, image-based multicellular signatures which are prognostic of metastasis. In this study we explored whether NACT alters other image-based prognostic/predictive signatures, specifically second-harmonic generation (SHG) dire

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Brown, Powel H., Abhijit Mazumdar, William Tahaney, et al. "Abstract IA017: Targeting the mTOR pathway for the prevention of triple-negative breast cancer." Cancer Prevention Research 16, no. 1_Supplement (2023): IA017. http://dx.doi.org/10.1158/1940-6215.precprev22-ia017.

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Abstract Phase III cancer prevention clinical trials have shown that breast cancer prevention is feasible using anti-estrogen drugs. However, these drugs have not been widely accepted because of concerns about toxicity. In addition, anti-estrogen drugs do not prevent estrogen-negative breast cancers, including the most aggressive form of breast cancer, triple-negative breast cancer (TNBC), that does not express the estrogen receptor (ER), progesterone receptor, or the human epidermal growth factor receptor 2 (HER2). Our laboratory is focused on identifying growth-regulatory molecules that are

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Arvidson, Lisa, Reginaldo Prioli, Samuel Jensen, et al. "Abstract 4701: Spatial resolution of tumor and immune cell lineages in the hypoxic microenvironment of pancreatic ductal adenocarcinoma (PDAC)." Cancer Research 83, no. 7_Supplement (2023): 4701. http://dx.doi.org/10.1158/1538-7445.am2023-4701.

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Abstract Understanding how the tumor microenvironment (TME) evolves during tumorigenesis and therapeutic response is crucial to developing personalized treatments with the goal of improving cancer therapy. With robust and comprehensive multiplexed imaging technologies, immune biomarker antibodies can be used to interrogate immune cell lineages and structures. When combined with specific oncology biomarker antibodies, this approach can capture the immune response within the TME in a variety of neoplasms. The Cell DIVETM Multiplex Imaging Solution allows probing and imaging of dozens of biomarke

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Arvidson, Lisa, Reginaldo Prioli, Samuel Jensen, et al. "Abstract 4698: Reproducibility in spatial biology: reducing variables to improve the reliability of insight generation." Cancer Research 83, no. 7_Supplement (2023): 4698. http://dx.doi.org/10.1158/1538-7445.am2023-4698.

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Abstract There is an ongoing crisis in reproducibility in scientific studies, and studies in spatial biology are no exception. Cell DIVETM Multiplex imaging solution (Leica Microsystems) provides reliable workflow solutions to minimize variability from study to study. Cell DIVE allows probing and imaging of dozens of biomarkers on a whole tissue section with an iterative staining and dye inactivation workflow. At its core, Cell DIVE is designed to provide methods reproducibility, from tissue preparation, antigen retrieval, and sample imaging and slide storage. Cell DIVE is designed to work wit

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McQueeney, Kelley E., Patrick Bhola, Sarah J. Hill, and Anthony Letai. "Abstract 4309: Early apoptotic measurements of patient-derived organoids predict patient response to therapy." Cancer Research 83, no. 7_Supplement (2023): 4309. http://dx.doi.org/10.1158/1538-7445.am2023-4309.

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Abstract The use of imperfect models and ex vivo culture systems to try to predict patient drug response represents an enormous bottle neck in cancer treatment. Nonetheless, determining how effective an approved drug will be for an individual cancer patient, as well as identifying novel compounds that may be beneficial to a specific population often requires the use of primary tumor cells. Patient-derived organoids represent an intermediate between primary tumor cells, whose limited supply may hinder reliable drug testing, and cell lines, which often do not reflect what happens in vivo. Herein

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Gadde, Manasa, Elizabeth Schwabe, Kshithija Mulam, Lindsay Hill, and Christopher Bulow. "Abstract 1682: Bridging gaps in treatment resistance 2D models with the incorporation of 3D models." Cancer Research 83, no. 7_Supplement (2023): 1682. http://dx.doi.org/10.1158/1538-7445.am2023-1682.

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Abstract Introduction: 3D cellular models have become of increasing interest in anti-cancer drug discovery as a bridge between clinical models and traditional in vitro methods. An important component of this research is the comparison of drug-to-cell interactions and morphological characteristics between cells in mono-layer culture and the cells in 3D spheroids. Materials and Methods:The ResCu system is a novel long term, physiologically relevant culture system that avoids the need for passaging. It propagates tumoroids in a microenvironment that resembleshuman tissue. Cells with KRAS G12C mut

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Smith, Michael J., Chi-Chou Huang, Tuan H. Phan, et al. "Abstract 2871: Spatial landscape of the tumor microenvironment in pancreatic ductal adenocarcinoma using multiplexed imaging and AI based analysis." Cancer Research 83, no. 7_Supplement (2023): 2871. http://dx.doi.org/10.1158/1538-7445.am2023-2871.

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Abstract Pancreatic tumors are highly heterogenous, often with more aggressive regions that are responsible for invasion and metastasis. These aggressive pancreatic ductal adenocarcinoma (PDAC) cells undergo epithelial to mesenchymal transition and create subregions in the tumor that evade treatments and provide a critical support niche for continued tumor growth and metastasis. Conventional chemotherapy plus radiation, or in advanced disease chemotherapy plus targeted drug therapy can lengthen patient survival. However, even in patients with local disease, the 5-year survival rate remains at

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Dillon, Medbh A., Lisa Arvidson, Cole G. Phalen, et al. "Abstract 5331: Spatial resolution of immune cell lineages in the tumor microenvironment of plasma cell dyscrasias." Cancer Research 84, no. 6_Supplement (2024): 5331. http://dx.doi.org/10.1158/1538-7445.am2024-5331.

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Abstract Plasma cell dyscrasias (PCDs) are diseases of the hematologic system, with Multiple Myeloma as the most common disease. Less common PCDs include primary and secondary extramedullary plasmacytomas (EMP), which occur in soft tissues. EMPs are typically solitary and infrequent, often localized in the upper aerodigestive and gastrointestinal tracts, lung, and lymph nodes among other organs, and can convert to Multiple Myeloma. Secondary extramedullary plasmacytomas are often noted in advanced disease following multiple rounds of therapy and are commonly associated with poor prognosis. Stu

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Culp-Hill, Rachel, Charles Nichols, Collin Hill, et al. "Abstract 1925: Development of a multi-omics diagnostic approach for the early detection of ovarian cancer in asymptomatic women." Cancer Research 85, no. 8_Supplement_1 (2025): 1925. https://doi.org/10.1158/1538-7445.am2025-1925.

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Abstract Objectives: Ovarian cancer (OC) is the fifth leading cause of cancer-related deaths among women. Unfortunately, for most patients, detection of OC occurs at late stages (III/IV) when the five-year survival rate is &lt;30%. To change this paradigm, screening methods must be developed that are minimally invasive, highly sensitive, and disease specific. We have determined that utilizing multi-omics, which include novel classes of lipid and protein biomarkers with machine-learning, enables the robust detection of ovarian cancer across stages and subtypes, while requiring &lt;500µL

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Xiao, Weikun, Chae-Young Eun, Xinyu Zhang, et al. "Abstract 1567: Increased extracellular matrix stiffness induces hypersecretion of chemoresistance-promoting cancer associated fibroblast-derived exosomes in pancreatic cancer." Cancer Research 82, no. 12_Supplement (2022): 1567. http://dx.doi.org/10.1158/1538-7445.am2022-1567.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer with few effective treatments. Despite recent advances in in other cancers, the five-year survival rate of PDAC is still only 10%, with most patients succumbing to their disease within the first year. One of the main factors responsible for this poor outcome is the development of chemoresistance in nearly all clinical cases. While the intrinsic factors that facilitate chemoresistance in the tumor cells have been studied extensively, fewer studies have elucidated how the complex and unique microenvironmen

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Hill, Kristen S., Evan R. Roberts, Xue Wang, et al. "Abstract PR13: PTPN11 plays oncogenic roles and is a therapeutic target for BRAF wild-type melanomas." Cancer Research 80, no. 19_Supplement (2020): PR13. http://dx.doi.org/10.1158/1538-7445.mel2019-pr13.

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Abstract Melanoma is one of the most highly mutated cancer types, harboring numerous alterations with unknown significance. To identify functional drivers of melanoma, we searched for cross-species conserved mutations utilizing a mouse melanoma model driven by loss of PTEN and CDKN2A, and identified mutations in Kras, Erbb3, and Ptpn11. PTPN11 encodes the SHP2 protein tyrosine phosphatase (PTP) that activates the RAS/RAF/MAPK pathway. Although PTPN11 is an oncogene in leukemia, lung, and breast cancers, its roles in melanoma are not clear. In this study, we found that PTPN11 is frequently acti

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Pahlavan, Mahsa, Weikun Xiao, Flora Eun, Chang-Il Hwang, and Reginald Hill. "Abstract PO-123: Development of a 3D biomimetic metastatic liver niche model for pancreatic cancer." Cancer Research 81, no. 22_Supplement (2021): PO—123—PO—123. http://dx.doi.org/10.1158/1538-7445.panca21-po-123.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer death in the United States with a 5-year survival rate of only 7%. Early diagnosis is very difficult and thus 53% of PDAC patients are diagnosed after metastasis has already occurred with liver being the most frequently affected site. Therefore, it is urgent to understand the mechanism that leads to PDAC metastasis in liver in order to develop potential therapeutics. Research shows that environment that comprises the metastatic niche has unique features that facilitate tumor growth and chemoresistance. Differen

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Pahlavanneshan, Mahsa, Weikun Xiao, Chae Young Eun, Chang-Il Hwang, and Reginald Hill. "Abstract 3513: Developing a 3D biomimetic liver metastatic niche model for pancreatic cancer." Cancer Research 83, no. 7_Supplement (2023): 3513. http://dx.doi.org/10.1158/1538-7445.am2023-3513.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer death in the Unites States with a 5-year survival rate of only 11%. Early diagnosis is very difficult and thus 53% of patients are diagnosed after metastasis has already occurred, with the liver being the most frequently affected site. Both primary tumors and metastases have highly fibrotic stroma. Thus, stromal targeting agents have the potential to benefit patients, even those with metastatic disease. However, in addition to different resident fibroblasts, a study based on a rapid autopsy program of metastati

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Mahgoub, Bayan, Weikun Xiao, and Reginald Hill. "Abstract 2349: Investigating the effect of ECM stiffness on macrophage-derived exosome secretion and PDAC organoid progression." Cancer Research 83, no. 7_Supplement (2023): 2349. http://dx.doi.org/10.1158/1538-7445.am2023-2349.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of only 11%. Current treatments that mostly target the cancer cells themselves, have not been able to significantly improve survival rates, meaning there is an urgent need for novel therapies. PDAC is unique among solid tumors because it exhibits extensive desmoplasia that is characterized by an abundance of extracellular matrix (ECM) components. In recent years, an increasing body of work has shown that cancer tissue is stiffer than normal tissue by a factor of 3 or more. This change in ECM stiffness has been shown to

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Lajmi, Luke, Wishrawana S. Ratnayake, Khandker M. Khalid та ін. "Abstract 4382: PKC-ι/ζ signaling is crucial for apoptosis/pyroptosis inhibition and invasiveness of glioblastoma cells through upregulation of β-catenin, PDK1/Akt1 and Smad cascades via 14-3-3". Cancer Research 84, № 6_Supplement (2024): 4382. http://dx.doi.org/10.1158/1538-7445.am2024-4382.

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Abstract Glioblastoma (GB) is an aggressive form of brain cancer derived from astrocytes. Poor predictability of patient outcomes has limited the development of current therapeutic treatments of GB mainly due to the development of drug resistance. Comparative over-expression of atypical protein kinase C-iota and zeta (aPKC-ι/ζ) in GB cells and tissue samples were previously reported. This study establishes the downstream effects of PKC-ι/ζ attenuation on key cellular signaling which governs apoptosis, pyroptosis, survival, proliferation and epithelial-mesenchymal transition (EMT). Our data sug

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Nah, Giselle, Yuk Kien Chong, Fatin Nasha Sulaimi, et al. "Abstract 4726: ETC-501, a novel brain penetrant MNK kinase inhibitor, potentiates TMZ-induced senescence and sensitizes glioblastoma cells to senolytic therapy." Cancer Research 85, no. 8_Supplement_1 (2025): 4726. https://doi.org/10.1158/1538-7445.am2025-4726.

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Abstract Glioblastoma (GBM), the most lethal primary brain tumor in adults, has a median survival of only 15 months, with fewer than 10% of patients surviving beyond five years. Despite aggressive multimodal therapies, including maximal surgical resection, radiation, and temozolomide (TMZ) chemotherapy, recurrence is almost inevitable. Contributing factors include incomplete resection, elevated levels of O6-methylguanine DNA methyltransferase that repair TMZ-induced DNA damage, therapy-resistant glioma stem cells, intratumoral heterogeneity, and the restrictive blood-brain barrier. Additionall

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Gedik, Mustafa Emre, Ozge Saatci, Kubra Calisir, et al. "Abstract 3863: Targeting TACC3 inhibits metastasis in breast cancer with centrosome amplification." Cancer Research 85, no. 8_Supplement_1 (2025): 3863. https://doi.org/10.1158/1538-7445.am2025-3863.

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Abstract Centrosome amplification (CA) is highly prevalent in cancer. It is strongly associated with tumor progression and worse prognosis in a variety of different cancers. Preclinical studies have demonstrated that CA can trigger tumor initiation as well as cancer cell invasion. Thus, CA is known to be a promising therapeutic target. We have previously identified Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) as being overexpressed in tumors with CA. TACC3 forms distinct functional interactomes regulating spindle stability, clustering extra centrosomes and transcription of key

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Ratcliffe, Laura, Sophie Vermond, Sophie Hill, et al. "Abstract LB009: Safety profile assessment for IND-enabling studies: Bispecific antibodies and antibody-drug conjugates (ADCs)." Cancer Research 85, no. 8_Supplement_2 (2025): LB009. https://doi.org/10.1158/1538-7445.am2025-lb009.

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Abstract Developing antibody-based therapeutics requires balancing potency and safety. Off-target effects can cause adverse events, necessitating precise target engagement and comprehensive safety profiling during early development. The work presented outlines a systematic approach to identify and mitigate off-target interactions for antibodies and ADCs. This de-risking roadmap which spans 12-16 weeks, evaluates on-target and off-target interactions, ensuring thorough vetting before IND-enabling studies. The de-risking platform uses two primary approaches: (1) Off-target analysis via Retrogeni

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Mayekar, Manasi, Deborah Caswell, Natalie Vokes, et al. "Abstract 2197: Targeted cancer therapy induces APOBEC fueling the evolution of drug resistance." Cancer Research 82, no. 12_Supplement (2022): 2197. http://dx.doi.org/10.1158/1538-7445.am2022-2197.

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Abstract Introduction: Increasing our understanding of drivers of mutagenesis in lung cancer is critical in our efforts to prevent tumor reoccurrence and resistance. Results: Using the multi-region TRACERx lung cancer study, we uncovered that APOBEC3B is significantly upregulated when compared with other APOBEC family members in EGFR driven lung cancer and identified subclonal enrichment of APOBEC mutational signatures. To model APOBEC mutagenesis in lung cancer, several novel EGFR mutant mouse models containing a human APOBEC3B transgene were generated. Using these models, it was uncovered th

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Moyer, Cassandra L., Abhijit Mazumdar, Jamal Hill, Martin E. Sanders, and Powel Brown. "Abstract P4-01-14: The RXR agonist, IRX4204, increases the anti-tumor activity of HER2-targeted therapies in HER2-amplified breast cancer." Cancer Research 82, no. 4_Supplement (2022): P4–01–14—P4–01–14. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-01-14.

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Abstract Background: HER2 targeted monoclonal antibodies and tyrosine kinase inhibitors (TKI) are effective treatments for HER2-amplified primary tumors. However, the challenge persists that primary and acquired resistance to anti-HER2 therapy is common, and that anti-HER2 targeted therapies fail to achieve a cure in the metastatic setting. There is a critical need for safe and effective therapies that can overcome anti-HER2 drug resistance and eliminate breast cancer metastases. Here, we present data demonstrating the activity of IRX4204, a highly specific agonist of the nuclear retinoid X re

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Kaninjing, Ernest, Gladys Asiedu, Kaitlin Van Voorhis, et al. "Abstract 1310: Social determinants of migrant health factors impacting prostate cancer care and survivorship among sub-Saharan African immigrant men diagnosed with prostate cancer." Cancer Research 84, no. 6_Supplement (2024): 1310. http://dx.doi.org/10.1158/1538-7445.am2024-1310.

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Abstract Background: Sub-Saharan African Immigrants (SSAI) represent one of the fastest-growing segments of the immigrant population in the United States (US). Between 2010 and 2018, the SSAI population in the US increased by 53%, significantly outpacing the 12% growth rate for the overall foreign-born population in the US during that time frame. Despite these growing numbers, little is published about the extent to which SSAIs adapt to health behaviors more common in the US or remain immersed in the values, beliefs and practices reflective of their country of origin. Importantly, no study has

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Chiang, Chun-Te, Danielle Hixon, Nevart Mooradian, et al. "Abstract A017: Exploring the interplay between macrophage subtypes and colorectal cancer cell growth." Cancer Immunology Research 11, no. 12_Supplement (2023): A017. http://dx.doi.org/10.1158/2326-6074.tumimm23-a017.

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Abstract Tumor-associated macrophages, a major stromal component within the tumor microenvironment (TME), play diverse roles in tumor progression and response to therapy. Although their tumor infiltration is linked to unfavorable prognoses in various cancer types, their specific involvement in colorectal cancer (CRC) remains a subject of debate. Within the TME, macrophages can adopt pro-inflammatory (M1) or immune-suppressive (M2) phenotypes in response to signals. In this study, we aimed to investigate the intricate interplay between CRC cells and macrophages under different tumor microenviro

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Graybuck, Lucas, Christian M. La France, Nicole Howard, et al. "Abstract 1071: Online resources from the Allen Institute for Immunology: longitudinal profiling of multiple myeloma treatment and the Human Immune System Explorer platform." Cancer Research 85, no. 8_Supplement_1 (2025): 1071. https://doi.org/10.1158/1538-7445.am2025-1071.

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Abstract The Allen Institute for Immunology was founded in 2018 to deeply profile the human immune system in health and disease. As part of our mission to understand how the immune system changes over time in the setting of oncology, we recruited a cohort of patients at diagnosis for multiple myeloma (MM), and followed these subjects throughout induction therapy, autologous stem cell transplant, and after transplant recovery. We sampled the same subjects longitudinally, then performed immune profiling using scRNA-seq on peripheral blood cells, CITE-seq on bone marrow cells, multiple high-dimen

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KITLV, Redactie. "Book Reviews." New West Indian Guide / Nieuwe West-Indische Gids 71, no. 3-4 (1997): 317–91. http://dx.doi.org/10.1163/13822373-90002612.

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-Leslie G. Desmangles, Joan Dayan, Haiti, history, and the Gods. Berkeley: University of California Press, 1995. xxiii + 339 pp.-Barry Chevannes, James T. Houk, Spirits, blood, and drums: The Orisha religion in Trinidad. Philadelphia: Temple University Press, 1995. xvi + 238 pp.-Barry Chevannes, Walter F. Pitts, Jr., Old ship of Zion: The Afro-Baptist ritual in the African Diaspora. New York: Oxford University Press, 1993. xvi + 199 pp.-Robert J. Stewart, Lewin L. Williams, Caribbean theology. New York: Peter Lang, 1994. xiii + 231 pp.-Robert J. Stewart, Barry Chevannes, Rastafari and other Af

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Dijkstra, Krijn K., Roberto Vendramin, Robert E. Hynds, et al. "Abstract 692: Patient-derived co-cultures of TRACERx lung cancer organoids and autologous T-cells reveal heterogeneity in immune evasion between cancer subclones." Cancer Research 82, no. 12_Supplement (2022): 692. http://dx.doi.org/10.1158/1538-7445.am2022-692.

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Abstract Introduction: Intra-tumor heterogeneity (ITH) is a major driver of treatment resistance. ITH also affects anti-tumor immunity, with immune cell infiltration, neo-antigen expression and T cell receptor (TCR) profiles differing between separate regions of an individual tumor. However, the extent to which separate tumor subclones differ in their capacity for immune evasion, the tumor-intrinsic mechanisms underlying any such heterogeneity, and its impact on cancer immunosurveillance remain largely unexplored. We have previously developed personalized models of anti-tumor immunity, based o

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Mazumdar, Abhijit, Jamal Hill, William Tahaney, et al. "Abstract 715: Targeting the mTOR pathway for the prevention of er-negative breast cancer." Cancer Research 82, no. 12_Supplement (2022): 715. http://dx.doi.org/10.1158/1538-7445.am2022-715.

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Abstract Background: Triple-Negative breast cancer (TNBC) is an aggressive cancer that lacks expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. These cancers have a poor prognosis and are treated predominantly with chemotherapy. Therefore, we are working to find preventive therapies for these potentially lethal cancers. Dysregulation of PI3K-mTOR pathway is commonly associated with TNBC and other ER-negative breast cancers. We hypothesized that targeting mTOR may prevent development of ER-negative breast cancers and in this study tested wh

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Torres, Keila E., Charlotte N. Hill, Dario Rocha, et al. "Abstract 2517: Characterization of the immune microenvironment of Epstein-Barr virus associated gastric cancer." Cancer Research 82, no. 12_Supplement (2022): 2517. http://dx.doi.org/10.1158/1538-7445.am2022-2517.

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Abstract Consistent with better clinical outcome, Epstein-Barr Virus associated gastric cancer (EBVaGC) displays a particular expression pattern of immunological genes and is highly infiltrated by effector immune cells. To decipher potential mechanisms linking tumor infiltrating lymphocytes (TILs) with an expression of immune-related genes in EBVaGC we utilized RNAseq gene expression data from The Cancer Genome Atlas (TCGA) Stomach Adenocarcinoma (STAD) dataset and performed cellular deconvolution analyses by a mixed approach including two complementary approaches (MIXTURE and xCell). In accor

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Shi, Gongping, Sayantan Banerjee, Xin Li, et al. "Abstract 1355: Lipid-rich foamy macrophages along with CD4 T cell-derived signaling drive aberrant lipid metabolism and are a cause of lung cancer development." Cancer Research 82, no. 12_Supplement (2022): 1355. http://dx.doi.org/10.1158/1538-7445.am2022-1355.

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Abstract Previously we reported that bone marrow-derived macrophages are required for lung squamous cell carcinoma development in kinase-dead Ikkα knockin (KA/KA) mice. The KA/KA lungs display strikingly enlarged sizes, sustained inflammation with increased expression of multiple cytokines and chemokines and marked infiltrating macrophages and T cells, and tissue damage, which look like a “burning hill”. To determine a critical event for the pathogenesis of the lung disease and SCC development, in this study, we found that these F4/80+CD11b+CSF1R+ monocyte-derived macrophages isolated from KA/

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Hill, Brianna L., Sarah M. Sywanycz, Zoey A. Miller, Robert J. Lee, and Ryan M. Carey. "Abstract A051: Bitter agonists increase macrophage phagocytosis of head and neck squamous cell carcinoma cells." Cancer Immunology Research 12, no. 10_Supplement (2024): A051. http://dx.doi.org/10.1158/2326-6074.tumimm24-a051.

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Abstract Head and neck squamous cell carcinoma (HNSCC) is the 7th most commonly diagnosed cancer worldwide and is expected to increase in incidence by 30% by 2030. The HNSCC microenvironment is characterized by substantial macrophage infiltration. However, tumor-associated macrophages often cultivate an immunosuppressive environment that aids tumor progression. Previous work has shown that macrophages express bitter taste receptors (T2Rs), a class of GPCRs that can be activated with bitter compounds. Previous work has also demonstrated that stimulation of T2Rs in macrophages with bitter agonis

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Higgins, Taylor-Jade, Jayesh Sharma, Elizabeth R. Zhang-Velten, et al. "Abstract 3584: Early and non-invasive detection of radiation-induced cardiotoxicity in pre-clinical and clinical models." Cancer Research 83, no. 7_Supplement (2023): 3584. http://dx.doi.org/10.1158/1538-7445.am2023-3584.

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Abstract Background: Nearly half of all patients receive radiation therapy as a component of their cancer care. Despite the efficacy of radiation therapy as a cancer treatment, cardiotoxicity is a major concern in patients receiving chest radiotherapy. There are currently no standardized approaches for early detection of radiation-induced cardiotoxicity as a stage that offers potential for early intervention. In this study, we employ hyperpolarized 13C- pyruvate magnetic resonance spectroscopy to non-invasively characterize early metabolic changes in the heart in response to radiation. Methods

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Breedy, Sloan, Wishrawana S. Ratnayake, Luke Lajmi, Robert Hill, and Mildred Acevedo-Duncan. "Abstract 2555: 14-3-3 and Smad2/3 are key mediators of atypical-PKCs in neuroblastoma progression." Cancer Research 83, no. 7_Supplement (2023): 2555. http://dx.doi.org/10.1158/1538-7445.am2023-2555.

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Abstract Neuroblastoma (NB) is a cancer that develops in the neuroblasts. It is the most common cancer in children under the age of 1 year, accounting for approximately 6% of all cancers. The prognosis of NB is linked to both age and degree of cell differentiation. This results in a range of survival rates for patients, with outcomes ranging from recurrence and mortality to high survival rates and tumor regression. Our previous work indicated that PKC-ι promotes cell proliferation in NB cells through the PKC-ι/Cdk7/Cdk2 cascade. We report on two atypical protein kinase inhibitors as potential

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Dillon, Medbh A., Kevin J. Lee, Cole G. Phalen, et al. "Abstract 3970: Advancing multiple myeloma research: patient-derived 3D Organ-on-a-Chip models to reveal immunological mechanisms influencing cancer growth and resistance." Cancer Research 85, no. 8_Supplement_1 (2025): 3970. https://doi.org/10.1158/1538-7445.am2025-3970.

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Abstract Multiple myeloma (MM) is characterized by malignant plasma cells infiltrating the bone marrow. The standard induction therapy for MM includes combining bortezomib, lenalidomide and dexamethasone (VRd); this has recently expanded to include an anti-CD38 antibody, which has improved patient outcomes. Despite the recent advances in treatment, patients with MM commonly relapse and it is a disease that remains ultimately incurable. More advanced patient-derived 3D models would allow a greater understanding of the tumor microenvironment (TME) and how it changes during treatment. This is nee

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Puddu, Fabio, Annelie Johansson, Aurélie Modat, et al. "Abstract 3265: 5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 3265. https://doi.org/10.1158/1538-7445.am2025-3265.

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Abstract Early cancer detection has the potential to significantly improve treatment outcomes and survival rates. Epigenetic biomarkers in cell-free DNA, including DNA methylation, have been shown to differentiate between cancer and non-cancer and are already being integrated into liquid biopsy development programs. Traditional DNA methylation sequencing provides a conflated modified Cytosine (modC) readout, measuring CpGs that are 5-methylcytosine (5mC) or 5-hydroxymethylcytosine (5hmC) but not discriminating between the two states. Dynamic DNA demethylation occurs through TET enzyme activity

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Lucci, Alavaro, Anna E. Barry, Victoria Johnson, et al. "Abstract LB317: Liquid-liquid phase separation drives tumorigenesis by modulating the chromatin accessibility of paused and non-paused genes in hepatocellular carcinoma." Cancer Research 85, no. 8_Supplement_2 (2025): LB317. https://doi.org/10.1158/1538-7445.am2025-lb317.

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Abstract Biomolecular condensates partition various cellular processes including transcription, DNA repair, and RNA metabolism. Pol II pausing occurs in more than 30% of all genes and a mechanism for cells to control and synchronize transcription. Pol II pausing is important in maintaining cellular homeostasis and response to stress, which is facilitated by Negative Elongation Factor (NELF) complex. NELF includes four proteins, NELFA, NELFB, NELFC/D, and NELFE. It is known that NELF requires interaction with nascent RNA (via NELFE) to initiate pausing and speculated that nucleosomal accessibil

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Lane, Alan. "Ronan Toolis & Christopher Bowles . The lost Dark Age kingdom of Rheged: the discovery of a royal stronghold at Trusty's Hill, Galloway. 2016. vi+169 pages, several colour and b&w illustrations. Oxford & Philadelphia (PA): Oxbow; 978-1-78570-311-9 hardback £30." Antiquity 91, no. 358 (2017): 1114–15. http://dx.doi.org/10.15184/aqy.2017.114.

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Kwant, Kathryn Strobel, Sony S. Rocha, Timothy Yu, et al. "Abstract 2861: TriTAC-XR: An extended-release T cell engager platform designed to minimize cytokine release syndrome." Cancer Research 82, no. 12_Supplement (2022): 2861. http://dx.doi.org/10.1158/1538-7445.am2022-2861.

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Abstract CD3-targeted T cell engagers are potent anti-tumor therapies, but their development often requires management of cytokine release syndrome (CRS). One strategy to reduce CRS is subcutaneous dosing, which is hypothesized to mitigate CRS by reducing the maximum drug concentration (Cmax) and preserve efficacy by maintaining the same minimum drug concentration (Cmin) as intravenous dosing. Although promising for mitigating CRS, this approach is limited by its increased immunogenicity risks. A T cell engager designed to be dosed intravenously but engineered to mimic the PK properties of sub

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Hashtarkhani, Soheil, Shelly White-Means, Sam Li, et al. "Abstract C008: Exploring socioeconomic and racial influences on breast cancer comorbidity in the Memphis metropolitan area: A geospatial and machine learning analysis." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (2024): C008. http://dx.doi.org/10.1158/1538-7755.disp24-c008.

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Abstract Introduction Memphis, Tennessee, ranks among the top U.S. cities for breast cancer mortality, especially among African American women. Breast cancer presents a significant public health challenge, exacerbated by various comorbid conditions that complicate patient outcomes. The Charlson Comorbidity Index (CCI) predicts ten-year mortality risk based on comorbid conditions, with higher scores indicating greater risk. Despite its importance, localized data on factors influencing CCI scores among breast cancer patients is limited. This study aims to identify spatial hotspots of breast canc

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Rocha, Sony S., Regina Lin, Maria R. Dayao, et al. "Abstract 2928: TROP2 ProTriTAC™, a protease-activated T cell engager prodrug targeting TROP2 for the treatment of solid tumors." Cancer Research 83, no. 7_Supplement (2023): 2928. http://dx.doi.org/10.1158/1538-7445.am2023-2928.

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Abstract Tumor-associated calcium signal transducer 2 (Trop2) is a cell surface glycoprotein that promotes cell renewal, proliferation and tumorigenesis. Trop2 is homogenously overexpressed in numerous solid tumor types, including breast, head and neck, prostate, bladder, and non-small cell carcinoma; however, Trop2 is also expressed in several normal tissues, including skin, respiratory tract, and female reproductive organs. Although Trop2-targeted antibody drug conjugates (ADCs) have demonstrated clinical activity, with regulatory approvals in subsets of breast and bladder cancers, their bro

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Scott, Nina, Myra Ruka, and Amy R. Jones. "Abstract 5278: Cancer WHIRI research: Improving the early cancer pathway for indigenous NZ peoples." Cancer Research 82, no. 12_Supplement (2022): 5278. http://dx.doi.org/10.1158/1538-7445.am2022-5278.

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Abstract Background: Māori, Indigenous peoples of New Zealand (NZ) are twice as likely to die after a diagnosis of cancer compared to non-Māori. Cancer pathways are not designed for Māori health gain and are not pandemic resilient. Māori receive delayed poorer quality treatment and those with comorbidities are undertreated [1]. Existing inequities from time of referral to cancer services through to treatment were exacerbated by the COVID-19 response in Aotearoa NZ. Coordination of care is crucial for Māori patients and whānau (family), but poorly developed along this early part of the cancer p

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Elgamal, Ola A., Sandip Vibhute, Sydney Fobare, et al. "Abstract 1060: Introducing a novel DHODH inhibitor with superior in vivo activity as monotherapy or in novel combination regimen with immunotherapy for hematological malignancies." Cancer Research 82, no. 12_Supplement (2022): 1060. http://dx.doi.org/10.1158/1538-7445.am2022-1060.

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Abstract Acute myeloid leukemia (AML) is characterized by the uncontrolled expansion of un-differentiated hematopoietic progenitor myeloblasts. AML treatment is very challenging owing to its complex heterogeneity resulting in a dismal 5-year overall survival rate particularly in elderly patients unfit for standard induction chemotherapy. The expansion of AML requires the availability of sufficient nucleotides supporting the anabolic processes required for AML growth thus, targeting nucleotide biosynthesis can halt AML progression. Indeed, targeting dihydroorotate dehydrogenase (DHODH), a criti

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Bichoo, Raouef Ahmed, Mohammed Bilal Elahi, Dorin Dumitru, et al. "Abstract P1-01-06: Predictor of sentinel node positivity in screen-detected invasive breast cancer." Cancer Research 82, no. 4_Supplement (2022): P1–01–06—P1–01–06. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-01-06.

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Abstract Introduction: Sentinel lymph node biopsy represents the standard of care for staging axilla in breast cancer patients who are clinically node negative. ACOSOG Z11 trial results questioned the importance of low burden nodal disease. Results from the SOUND trial on omission of axillary surgery in selected patients with early stage breast cancer are still awaited. Breast screening programs aim to detect cancers at an early stage and are expected to have low burden of nodal disease. The aim of our study was to determine predictors of sentinel node biopsy positivity in invasive breast canc

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