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Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Voyle, Roger Bruce. "Mechanisms of intracellular and extracellular cytokine production from the human leukaemia inhibitory factor gene." Title page, contents and summary only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phv975.pdf.

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Addendum attached to back facing leaves. Includes bibliographical references (leaves 172-199). The findings establish leukemia inhibitory factor, and possibly oncostatin M, as new members of a small but growing class of cytokines produced in an intracellularly active form and also suggest that the production of alternate transcripts and intercellularly-retained proteins may be a common and important feature of cytokines of the IL-6 and other families.

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Haines, Bryan Peter. "Alternate transcription and translation of the LIF gene produces a novel intracellular protein /." Title page, contents and summary only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phh1518.pdf.

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Zhang, Xiyuan. "The expression of human leukemia inhibitory factor in Pichia pastoris." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29919.

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Background: Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that inhibits cell differentiation during cell development. LIF is widely used as an important component in stem cell culture medium for cell therapy and tissue engineering applications, to inhibit spontaneous cell differentiation. However, commercially available recombinant LIF proteins are expensive, unstable, and prone to degradation in prolonged tissue culture, which has limited its applications. Purpose: We aim to develop a lab-scale method, using a yeast cell, namely, P. pastoris, to produce recombinant hL

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4

Hsu, Li-Wei. "Structure and expression of murine leukemia inhibitory factor (LIF) gene." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334839.

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5

Davis, Stephanie. "Leukemia Inhibitory Factor as a Neuroprotective Agent against Focal Cerebral Ischemia." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6218.

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Previous publications from this laboratory demonstrated that administration of leukemia inhibitory factor (LIF) (125 µg/kg) to young, male Sprague-Dawley rats at 6, 24, and 48 h after middle cerebral artery occlusion (MCAO) reduced infract volume, improved sensimotor skills, and alleviated damage to white matter at 72 h after the injury. In vitro studies using cultured oligodendrocytes (OLs) showed that LIF (200 ng/ml) also protects against 24 h of oxygen-glucose deprivation through activation of Akt signaling and upregulation of the antioxidant enzymes peroxiredoxin IV and metallothionein III

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6

Schiemann, William Paul. "Determination and characterization of leukemia inhibitory factor receptor signal transduction systems /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/6277.

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Ng, Yu Pong. "Leukemia inhibitory factor receptor signaling in NGF-induced neuronal differentiation of PC12 cells /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BICH%202004%20NG.

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Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2004.<br>Includes bibliographical references (leaves 134-172). Also available in electronic version. Access restricted to campus users.

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8

Alberti, Kristin. "Biologische Verfügbarkeit des Zytokins Leukemia inhibitory factor nach kovalenter Ankopplung an Polymeroberflächen." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-65099.

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Für medizinische Anwendungen sind Stammzellen aufgrund ihrer Eigenschaften (Selbsterneuerung, hohe Proliferationsrate und Differenzierungsmöglichkeit in verschiedene Zelltypen) beispielsweise in den Bereichen des regenerativen Gewebeersatzes und der Zelltherapie sehr interessant. In vivo umgibt die Stammzellen eine definierte Mikroumgebung, die sie unterstützt sich zu teilen, ihren undifferenzierten Status aufrecht zu erhalten und Tochterzellen für das Wachstum, die routinemäßige Erneuerung oder den Ersatz von Gewebe zu produzieren. Diese Mikroumgebungen werden als Stammzellnischen bezeichnet.

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9

Port, Martha D. "Regulation of expression and function of neurokine receptors /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/6283.

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10

Gascan, Hugues. "Caracterisation du facteur de croissance hilda : leukemia inhibitory factor produit par des cellules tumorales humaines." Nantes, 1988. http://www.theses.fr/1988NANT04VS.

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11

Leduc, Katy. "Influence du facteur gestationnel leukemia inhibitory factor sur la différenciation cellulaire d'un modèle de trophoblaste humain." Thèse, Université du Québec à Trois-Rivières, 2011. http://depot-e.uqtr.ca/2696/1/030294663.pdf.

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12

Ure, Daren Raymond. "Retrograde signaling and retrograde axonal transport of leukemia inhibitory factor and nerve growth factor by cultured sympathetic neurons." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21648.pdf.

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13

Subang, Maria Cristina. "The regulation of ciliary neurotrophic factor, leukemia inhibitory factor and monocyte chemoattractant protein-1 in injured peripheral nervous tissue." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0034/NQ64675.pdf.

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14

Malki, Marwa. "Correlations between unexplained infertility and single nucleotide polymorphism in the genes of leukemia inhibitory factor receptor and gp130." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128921.

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<p>About 30 % of all infertile couples suffer from infertility of an unexplained cause. Leukemia inhibitory factor (LIF) is a glycoprotein produced by the endometrium and is an important cytokine in the implantation process. LIF exerts its biological functions through heterodimerization of its two receptors: LIF receptor (LIFR) and gp130. Point mutations in the LIF gene have been associated with female infertility. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes of LIFR and gp130 could cause reduced fertility in women. To this end, 115 sampl

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15

Segrave, Alicia Maree. "An investigation of the pharmacokinetics and lymphatic transport of recombinant human leukaemia inhibitory factor." Monash University, Dept. of Pharmaceutics, 2004. http://arrow.monash.edu.au/hdl/1959.1/9389.

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16

Wooldridge, Lydia Katherine. "Supplementing Bovine Embryo Culture Media to Improve the Production and Quality of In Vitro Produced Bovine Embryos." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/105143.

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Initial studies in this work explored the role of interleukin-6 (IL6) and leukemia inhibitory factor (LIF) in preimplantation bovine embryos. Neither cytokine affected the total percentage of embryos which developed to the blastocyst stage in vitro. However, supplementation of IL6 increased blastocyst inner cell mass (ICM) cell number without affecting trophectoderm (TE) cell number. Additionally, we found that IL6 activated signal transducer and activator of transcription 3 (STAT3) specifically within ICM cells. LIF, however, did not affect ICM cell number or activate STAT3 in ICM cells, and

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17

Curley, Michael Kings. "Dissecting the paracrine interactions contributing to normal testicular function and during the ageing process." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/28972.

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The mammalian testis is divided into two distinct compartments which carry out its principal functions. Spermatogenesis occurs within the seminiferous tubules and androgen biosynthesis primarily occurs in the interstitial space. Both these processes are entirely dependent upon the two major testicular somatic cell populations - the Sertoli and Leydig cells respectively. In human males, testicular spermatogenic and endocrine function declines during the ageing process. Of particular significance is the reported age-related decrease in Leydig cell androgen production as androgens have been sugge

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18

Albrengues, Jean. "Rôle de la cytokine Leukemia Inhibitory Factor (LIF) dans l'activation et le maintien des fibroblastes pro-invasifs lors de la carcinogénèse." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4107/document.

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Le stroma inflammatoire joue un rôle primordial lors de la carcinogénèse. Dans ce contexte, nous montrons que la cytokine LIF est à l'origine d'une population de fibroblastes capable de remodeler la matrice extracellulaire de manière à la rendre permissive à l'invasion collective des cellules tumorales. En effet, nous montrons que la production de LIF par les cellules tumorales et fibroblastiques, après une stimulation au TGFβ, va réguler les capacités contractiles et pro-invasives de ces dernières via la régulation du cytosquelette d'acto-myosine et de manière indépendante de l'expression de

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19

Knezic, Barbara [Verfasser], Ivo [Gutachter] Quack, and Matthias [Gutachter] Schott. "Die Bedeutung des Leukemia Inhibitory Factor für die Funktion muriner und humaner Podozyten / Barbara Knezic ; Gutachter: Ivo Quack, Matthias Schott." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2017. http://d-nb.info/1138833819/34.

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20

Srugies, Fabian [Verfasser]. "Untersuchung der Rolle von Leukemia Inhibitory Factor in der Therapie der renalen Inflammation und Fibrose im unilateralen Ureterobstruktionsmodell / Fabian Srugies." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1163108057/34.

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21

Morimoto, Tatsuya. "GATA-5 Is Involved in Leukemia Inhibitory Factor-Responsive Transcription of the β-Myosin Heavy Chain Gene in Cardiac Myocytes". Kyoto University, 2000. http://hdl.handle.net/2433/180844.

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22

Albrengues, Jean. "Rôle de la cytokine Leukemia Inhibitory Factor (LIF) dans l'activation et le maintien des fibroblastes pro-invasifs lors de la carcinogénèse." Electronic Thesis or Diss., Nice, 2014. http://theses.unice.fr/2014NICE4107.

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Le stroma inflammatoire joue un rôle primordial lors de la carcinogénèse. Dans ce contexte, nous montrons que la cytokine LIF est à l'origine d'une population de fibroblastes capable de remodeler la matrice extracellulaire de manière à la rendre permissive à l'invasion collective des cellules tumorales. En effet, nous montrons que la production de LIF par les cellules tumorales et fibroblastiques, après une stimulation au TGFβ, va réguler les capacités contractiles et pro-invasives de ces dernières via la régulation du cytosquelette d'acto-myosine et de manière indépendante de l'expression de

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23

Boudreault, Lydia. "Étude d'association entre des polymorphismes du gène du récepteur de leukemia inhibitory factor et la densité osseuse chez les femmes canadiennes françaises." Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/29524/29524.pdf.

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24

Setati, Mokgadi Michael. "The potential roles of interactions between STAT3, Hsp90, and Hop in the maintenance of self-renewal in mouse embryonic stem cells." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1004040.

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Self-renewal of mouse embryonic stem (mES) cells is dependent upon the presence of leukemia inhibitory factor (LIF). LIF induces tyrosine phosphorylation and nuclear translocation of STAT3 (signal transducer and activator of transcription 3) which is thought to promote self-renewal by inducing key target genes. The molecular chaperone heat shock protein 90 (Hsp90) is involved in signal transduction pathways and regulates STAT3 activity in different cell types. However, the role of Hsp90 in regulating STAT3 activity in mES cells has not previously been investigated. The aim of this study was to

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25

Isber, Marc. "Caractérisation d’aptamères ADN inhibiteurs de l’activité de STAT5B, une protéine impliquée dans les leucémies." Thesis, Compiègne, 2016. http://www.theses.fr/2016COMP2305.

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STAT5A et B sont des facteurs de transcription qui constituent le point de convergence de nombreux signaux extracellulaires. Parmi leurs fonctions biologiques, ils sont connus pour leur rôle dans le développement et la différentiation des cellules hématopoïétiques. Cependant, un taux d’activation et/ou d’expression élevé de ces protéines aboutit à une prolifération incontrôlée des cellules aboutissant ainsi à une leucémogenèse. Ce présent travail vise à caractériser des aptamères ADN (Apta1 et Apta2) sélectionnés préalablement au sein de notre laboratoire contre STAT5B afin de réguler son acti

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26

Laranjeira, Forti André Luis [Verfasser], Udo [Akademischer Betreuer] Markert, Jochen G. [Akademischer Betreuer] Mainz, and Udo [Akademischer Betreuer] Jeschke. "Current aspects of leukemia inhibitory factor (LIF) and its signaling pathways in choriocarcinoma cell lines / Andre Luis Laranjeira Forti. Gutachter: Udo Markert ; Jochen G. Mainz ; Udo Jeschke." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2014. http://d-nb.info/1047096943/34.

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27

Lorgeot, Valérie. "Contribution à l'étude du rôle de l'acetyl-N-SER-ASP-LYS-Pro (AcSDKP) dans l'Hémapotoiese et du leukemia inhibitory factor (LIF) dans des processus physiologiques et pathologiques." Limoges, 1997. http://www.theses.fr/1997LIMO107G.

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28

Runesson, Liselotte. "CORRELATION BETWEEN ENDOMETRIAL MARKERS AND PREGNANCYOUTCOME IN WOMEN WITH UNEXPLAINED INFERTILITY." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126380.

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<p>ABSTRACT</p><p>A defect implantation process is the major reason for unexplained infertility. Estrogen andprogesterone are steroid hormones preparing the endometrium for implantation. They mediatetheir effect through their receptors: estrogen receptor alpha and beta and progesteronereceptor A and B, respectively. Leukemia inhibitory factor (LIF), which is also important forimplantation, mediates its effect through LIF receptor and the coreceptor, gp130, and is downregulated by suppressors of cytokine signaling 1. The aim of the study was to compare thelevels of the steroid hormone receptors

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Rowe, Derrick. "Secreted Factors from Human Umbilical Cord Blood Cells Protect Oligodendrocytes from Ischemic Insult." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3323.

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Oligodendrocytes (OL)s are the dominant cell type in the white matter and are integral for synaptic transmission essential for proper neuronal communication between brain areas. Previous studies have shown that intravenous administration of the mononuclear fraction of human umbilical cord blood (HUCB) cells in rat models of stroke reduced white matter injury, gray matter injury and behavioral deficits. Yet the mechanisms used by HUCB cells remain unknown in ischemic injury. These studies will investigate both in vitro and in vivo approaches to elucidate this mechanism in OLs. When mature prima

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Pietro, Luciana 1981. "Expressão dos fatores LIF (Fator Inibitório de Leucemia), IL-6 (Interleucina-6), STAT-3 (Ativador de Transcrição-3) e telomerase em coriocarcinomas." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310449.

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Orientadores: Liliana Aparecida Lucci de Angelo Andrade, Fatima Aparecida Böttcher-Luiz<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-24T02:59:06Z (GMT). No. of bitstreams: 1 Pietro_Luciana_D.pdf: 3492137 bytes, checksum: 723d823e8ddb16925da7aa8f48f22ea1 (MD5) Previous issue date: 2013<br>Resumo: A invasão do endométrio pelo trofoblasto extraviloso é fundamental no desenvolvimento do feto e da placenta, processo este controlado por fatores ligados à atividade imunológica e hormonal que, quando alterada, pode resu

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Schmitz, Carla Regina. "Avaliação da Milk Fat Globule Epidermal Growth Factor 8 (MFG-E8), da integrina αvβ3 e da Leukemia Inhibitory Factor (LIF) na implantação embrionária humana : estudo em modelo in vitro e no endométrio de mulheres com e sem endometriose". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/131165.

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Base teórica: O processo de implantação do embrião no ser humano é extremamente complexo e, ao mesmo tempo, essencial para que a mulher possa engravidar. Neste processo, em que o endométrio precisa sofrer uma série de mudanças para tornar-se receptivo, a adequada expressão de MFG-E8 (milk fat globule epidermal growth factor 8), seu receptor a integrina αvβ3 e LIF (leukemia inhibitory factor) parecem ter um papel importante. Além do mais, mulheres com infertilidade e endometriose podem apresentar a falha de implantação como uma grande barreira para obter seu sucesso terapêutico. Objetivos: Aval

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Alexandrou, Estella. "The therapeutic effect of LIF in EAE-associated axonal injury." Connect to thesis, 2009. http://repository.unimelb.edu.au/10187/5514.

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Axonal degeneration is a major pathological feature of the central nervous system (CNS) inflammatory demyelinating disease multiple sclerosis (MS). This axonal degeneration has major consequences, as functional axonal regeneration in the CNS is largely absent. Cumulative axonal degeneration is the likely cause of the majority of progressive MS-related disability, and therefore, the need for novel neuroprotective therapies for MS exists. Experimental autoimmune encephalomyelitis (EAE), an animal model of MS pathology, also produces axonal injury. In particular, the optic nerve and spinal cord

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Escary, Jean-Louis. "Étude fonctionnelle des gènes codant pour la cytokine LIF et pour son récepteur chez la souris." Paris 6, 1994. http://www.theses.fr/1994PA066566.

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Le LIF est un facteur protéique dont l'action biologique est pléiotropique in vitro et in vivo. En effet, en fonction du type de cellules cibles, cette action varie de la survie et/ou la prolifération à la différenciation. En particulier, le LIF induit la survie et la prolifération des cellules souches embryonnaires de souris (les cellules es). La technologie de recombinaison homologue dans ces cellules nous a permis d'obtenir une lignée de souris mutantes pour le LIF, appelées souris LIF-/-, dans laquelle le gène LIF n'est plus fonctionnel. Plusieurs fonctions biologiques différentes sont alt

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Whiteside, Eliza Jane. "The expression and regulation of metalloproteinases during normal and malignant trophoblast invasion." Thesis, Queensland University of Technology, 2001.

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山國, 尚志. "ラット中枢神経系におけるleukemia inhibitory factorおよびその受容体の発現と機能に関する分子薬理学的研究". 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/149582.

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Tjernlund, Annelie. "Leukemia inhibitor factor (LIF) and gp130 in early defence against HIV-1 infection /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7357-039-7/.

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Castro, Karla Ribeiro de. "Efeitos da exposição crônica à poluição atmosférica urbana sobre a receptividade uterina: estudo morfo-funcional do remodelamento celular do endométrio e expressão de fatores envolvidos na preparação para implantação embrionária." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-05112013-155805/.

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Evidências epidemiológicas associam diferentes fatores ambientais, tais como poluição e ingestão de alimentos contaminados, com desfechos gestacionais negativos e fertilidade diminuída em humanos. Não há duvidas de que a poluição do ar nos grandes centros urbanos é capaz de provocar desfechos negativos sobre a gestação: baixo peso ao nascer, prematuridade, perda gestacional, entre outros. Entretanto, poucos estudos foram conduzidos para avaliar um possível efeito da exposição à poluição ambiental particulada do ar sobre a saúde reprodutiva feminina. O objetivo deste trabalho foi avaliar se a e

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Loussouarn, Claire. "Sélection et caractérisation d’aptamères oligonucléotidiques régulateurs de la protéine STAT5B, impliquée dans les leucémies." Thesis, Compiègne, 2014. http://www.theses.fr/2014COMP2137.

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Les cancers, qu’il s’agisse de leucémies ou de tumeurs solides, sont le résultat de proliférations cellulaires anormales et non contrôlées au sein des tissus. Ces proliférations anarchiques sont le reflet d’une surexpression et/ou sur-activation de protéines intracellulaires engendrées par un événement oncogénique. Aujourd’hui encore il est donc nécessaire de trouver de nouvelles molécules à usage thérapeutique ciblant spécifiquement ces protéines. C’est dans ce contexte que les facteurs de transcription STAT5 constituent de véritables cibles de choix puisque ces protéines participent activeme

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Wong, Ee Lin [Verfasser]. "The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation / Ee Lin Wong." Berlin : Freie Universität Berlin, 2019. http://d-nb.info/1201346711/34.

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Bewry, Nadine N. "STAT3 Contributes to Resistance Towards BCR-ABL Inhibitors in a Bone Marrow Microenvironment Model of Drug Resistance in Chronic Myeloid Leukemia Cells." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0002892.

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Ko, Rose Marie. "The effect of the AML1-ETO translocation on cell cycle tumor suppressor gene function." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2008r/ko.pdf.

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Nóbrega, Junior Jandui Escarião da. "Cultivo in situ de folículos ovarianos pré-antrais de cabras com esfingosina (S1P) e fator inibidor da leucemia (LIF)." Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/4056.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The manipulation of oocytes enclosed in follicles Ovarian Pre-Antral, allows increasing the reproductive potential of females from the isolation and cultivation. The follicular viability can be affected negatively correlated with age, malnutrition, exposure to radio or chemotherapy and health conditions. The alternatives are to use these research for development of culture media which provides the maintenance of viability allows the activation and follicular development in vitro, for subsequent fertilization. Physiologically vari

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Costa, Simone Vieira da. "Participação de proteínas tirosina quinase ativada por mitógenos (MAPKs) na indução do fator inibidor de leucemia (LIF) em células estromais da medula óssea de crianças com sindromes mielodisplásicas (SMD)." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-17122008-104414/.

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Em nosso trabalho anterior mostramos que dentre as citocinas analisadas, os níveis do mRNA de LIF nas células estromais pediátricas, de SMD e de SMD-LMA foram maiores quando comparados às células estromais de crianças saudáveis. No presente estudo, observamos um aumento tempo dependente nos níveis da proteína LIF após adição de SFB em todas as células analisadas (células estromais de crianças saudáveis, de SMD e de SMD-LMA). O envolvimento de p38, ERK e JNK na expressão LIF nestas células foi determinado pelo uso de inibidores dos membros das proteínas quinase ativadas por mitógenos: ERK (PD98

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Chang, Chi-Chen, and 張其真. "Application of Recombinant Leukemia Inhibitory Factor upon Reproduction." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/63497076893592922158.

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碩士<br>中國醫藥學院<br>醫學研究所<br>87<br>Application of Recombinant Leukemia Inhibitory Factor (r-LIF) upon Reproduction INTRODUCTION: Leukemia inhibitory factor (LIF) is a pleiotropic cytokine of the interleukin-6 family and has different biological actions in various tissue systems. LIF can regulates the growth and differentiation of embryonic stem cells, primordial germ cells, peripheral neurons, osteoblasts, adipocytes, and endothelial cells. It is also crucial for successful implantation of the embryo in mice. The role of LIF in reproduction will be discussed. ABSTRACT

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Haines, Bryan Peter. "Alternate transcription and translation of the LIF gene produces a novel intracellular protein / by Bryan Peter Haines." Thesis, 1997. http://hdl.handle.net/2440/19190.

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Errata inserted.<br>Includes bibliographical references.<br>xi, 119, [75] leaves, [21] leaves of plates : ill. (chiefly col.) ; 30 cm.<br>This study demonstrates a conserved structural organisation of the mouse LIF gene that produces three differentially localised proteins. This provides a mechanism for specific control of the sites of LIF action and mechanisms for mediating the variety of putative actions for the LIF gene. Intracellular localisation of the LIF protein provides another example of intracellular cytokine action, mediated by a novel mechanism and provides a system for separate an

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Hsieh, Yao-Yuan, and 謝耀元. "Application of Leukemia Inhibitory Factor (LIF) in Human Reproduction." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/28192053969887274625.

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碩士<br>中國醫藥學院<br>醫學研究所<br>89<br>Part 1. Recombinant Leukemia Inhibitory Factor (r-LIF) Enhance Pre-implantation Mouse Embryo Development In Vitro Objective: To assess the effect of human recombinant leukemia inhibitory factor (r-LIF) in mouse embryos. Materials and Methods: Female CB6F1 mice that were between 6 and 8 weeks old were superovulated by 10 IU pregnant mare‘s serum gonadotropin (PMSG) and 10 IU HCG intra-peritoneally; then mated with BDF1 male mice. Mice were divided randomly into three Groups, which included 1 Group of in vivo (Group 1) and 2 Groups of in vitro

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Chung, Yu-Len, and 鍾宇倫. "Expression of Recombinant Human Leukemia Inhibitory Factor in Escherichia coli." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/92211524886032625898.

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碩士<br>中國醫藥學院<br>醫學類<br>84<br>Expression of Recombinant Human Leukemia Inhibitory Factor in Escherichia coliHuman leukemia inhibitory factor is a multi functional growth factor. The pET29b(+)expression vector includes S.Tag and His.Tag nucleotide sequence, encoding a 15-amino acid S-peptide and a histidine hexmar. Protein tagged with these two polypeptidesare easy to be detected and purified. For this reason, we utilize Escherichia coli toproduce recombinant human leukemia inhibitory factor

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Cheng, Tzu-Chun, and 鄭自君. "Studies of the leukemia inhibitory factor on preimplantation mouse embryo development." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/55669318267040450092.

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博士<br>中山醫學大學<br>生物化學研究所<br>92<br>Good embryo development and receptive endometrium are essential factors for embryo implantation. Leukemia inhibitory factor (LIF) is an essential factor for implantation and establishment of pregnancy. However, its role in the development of preimplantation embryos remains controversial. The aim of this study is to assess the effects of LIF on development of preimplantation mouse embryo. We observe the relationship between the blastocyst morphology and the implantation rate for mice. Mouse blastocysts were then classified into 3 grades: grade I, small blastocys

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Alberti, Kristin. "Biologische Verfügbarkeit des Zytokins Leukemia inhibitory factor nach kovalenter Ankopplung an Polymeroberflächen." Doctoral thesis, 2010. https://tud.qucosa.de/id/qucosa%3A25506.

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Für medizinische Anwendungen sind Stammzellen aufgrund ihrer Eigenschaften (Selbsterneuerung, hohe Proliferationsrate und Differenzierungsmöglichkeit in verschiedene Zelltypen) beispielsweise in den Bereichen des regenerativen Gewebeersatzes und der Zelltherapie sehr interessant. In vivo umgibt die Stammzellen eine definierte Mikroumgebung, die sie unterstützt sich zu teilen, ihren undifferenzierten Status aufrecht zu erhalten und Tochterzellen für das Wachstum, die routinemäßige Erneuerung oder den Ersatz von Gewebe zu produzieren. Diese Mikroumgebungen werden als Stammzellnischen bezeichne

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Falconi, Dominic Jean-Marie. "Molecular and cellular mechanisms underlying leukemia inhibitory factor-induced inhibition of osteoblast differentiation." 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=478917&T=F.

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