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Rozprawy doktorskie na temat „Ligand Recognition”

Autor: Grafiati

Data publikacji: 6 września 2023

Data aktualizacji: 31 lipca 2025

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1

Baylies, Christian John. "Synthesis of multidentate pyridyl-thiazole ligands and ligand recognition studies." Thesis, University of Huddersfield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399824.

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Hughes, P. J. "Multivalent ligand recognition by pentraxins." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1473766/.

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The pentraxins, serum amyloid P component (SAP) and C-reactive protein (CRP) are target proteins for the development of treatments for amyloidosis and ischaemic injury, respectively, in humans. This study reports the first multivalent ligands capable of targeting all five SAP binding sites simultaneously. Ligands presenting five or ten D-proline headgroups and composed of five peptideglycol linkers emanating from ε-N-substituted lysine residues on a central cyclic peptide core were synthesised by solid phase peptide synthesis. The sub-nanomolar, ~250pM, binding affinity approximated by Isother

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3

McCleverty, Clare. "Structure-function studies of integrin-ligand recognition." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29664.

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Integrins are a large family of αβ heterodimeric cell surface receptors that interact with the extracellular matrix and/or counter-receptors on other cells. These interactions control the adhesion and migration of cells as well as regulating numerous signal transduction pathways. Integrins exist in low and high affinity states, subject to allosteric regulation. Integrin-ligand recognition is divalent cation-dependent and mediated by the α subunit N-terminal repeats, the β subunit I domain and in certain integrins, the α subunit I domain. Two competing models based upon structure predictions, t

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4

Roy, Julie. "Ligand recognition by the major urinary protein." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/27908/.

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Molecular Dynamics (MD) and Quartz Crystal Microbalance (QCM) techniques can provide unique insights into what drives protein-ligand association. The major urinary protein (MUP) binds small ligands in a deeply buried hydrophobic pocket. Detailed calorimetric studies have shown that ligand binding is driven by enthalpic effects, not entropic effects [1]. Previous studies have shown that this is due to 'dewetting' of the binding site cavity even in the absence of ligands, and have also characterised the complex changes in molecular flexibility that accompany ligand binding-features that may be c

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5

Croft, Edward. "Computational analyses of protein-ligand interactions." Thesis, University of York, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265562.

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6

Lind, Ulrika. "Functional analysis of ligand recognition by the glucocorticoid receptor /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4116-5/.

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7

Hatherley, Deborah. "Structural basis of ligand recognition by Myeloid Paired Receptors." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543484.

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8

Costanzi, Elisa. "Structural analysis of molecular recognition and ligand association processes." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3421838.

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Molecular recognition is a fundamental step in essentially any biochemical process. Detailed structural knowledge is crucial to have a better understanding of the processes in which the two interacting molecular partners are involved and can be exploited in several applied fields such as supramolecular design of new molecular assemblies, rational drug design, and enzyme engineering. In the context of molecular recognition, I have investigated (mainly by single crystal x-ray crystallography) some relevant protein-protein and protein-ligand systems in order to gain detailed structural insights

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9

Repicky, Sarah Elizabeth. "The Structural Basis for Ligand Recognition by Mouse Odorant Receptors." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/91.

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Mammalian odorant receptors (ORs) are Class I G-protein coupled receptors (GPCRs) located within the nasal epithelium. Odorant receptors interact with Galpha olfactory, a Galpha S type G-protein. Activated Galpha olfactory stimulates adenylate cyclase and the resulting increase in cAMP concentration opens cyclic nucleotide gated channels allowing Ca2+ to enter the cell. The increased Ca2+ then activates a Ca2+ activated Cl- channel which further depolarizes the cell. This depolarization initiates an action potential that reaches the axon of the olfactory sensory neuron located in the main

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10

Śledź, Paweł. "Novel biophysical approaches to the study of protein-ligand recognition." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610024.

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11

Han, Yaohua. "Quantum Chemical Study of Molecular Recognition in Protein-Ligand Complexes." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1373313907.

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12

Salmaso, Veronica. "Exploring protein flexibility during docking to investigate ligand-target recognition." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3421817.

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Ligand-protein binding models have experienced an evolution during time: from the lock-key model to induced-fit and conformational selection, the role of protein flexibility has become more and more relevant. Understanding binding mechanism is of great importance in drug-discovery, because it could help to rationalize the activity of known binders and to optimize them. The application of computational techniques to drug-discovery has been reported since the 1980s, with the advent computer-aided drug design. During the years several techniques have been developed to address the protein flexibil

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13

Orro, Graña Adolfo. "Examination of the role of binding site water molecules in molecular recognition." Thesis, SciLifeLab Stockholm, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-200164.

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A set of algorithms were designed, implemented and evaluated in order to, first, identifyclusters of conserved waters in binding pockets, i.e. hydration sites. Then, their contributionto the free energy of binding in a ligand-protein association was quantified by calculatingtheir enthalpy and entropy. The information obtained by using these algorithms couldcontribute to the development of new drugs by generating new ligands that target specifichigh-energy, unfavorable waters. Evaluation tests show that our algorithms can indeedprovide relevant data about how hydration sites influence ligand-pr

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14

Cuzzolin, Alberto. "Novel in silico approaches to depict the protein-ligand recognition events." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424818.

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The discovery and commercialization of a new drug is a long and expensive process. Such process is divided into different phases during which the phisico-chemical and therapeutic properties of the compounds are determined. In particular, the aim of the first phase is to verify whether the compound recognises and interacts efficiently with the target protein. In the last decade, several computational tools have been developed and used to support experimentalists. For this purpose, the scientist have to deal with high complex systems that are difficult to study in whole; thus, the methods and a

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15

Lacey, Katie. "Regulation of ligand recognition and endocytosis by the LOX-1 scavenger receptor." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589025.

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Lectin-like oxidised low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor that binds a wide range of ligands including oxidised low-density lipoprotein (OxLDL). LOX-1-mediated recognition of OxLDL can cause endothelial dysfunction and apoptosis. LOX-1 is implicated in foam cell formation and atherosclerotic plaque initiation and progression. The C-type lectin-like domain of LOX-1 binds OxLDL but the molecular basis for this recognition is unclear. Glycosidase or protease-mediated removal of exposed N-linked carbohydrates or protein epitopes on OxLDL led to the conclusion that LOX

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16

Yang, Hui. "Theoretical Studies of Molecular Recognition in Protein-Ligand and Protein-Protein Complexes." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1282339026.

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17

Montalvo, Acosta Joel José. "Computational approaches to molecular recognition : from host-guest to protein-ligand binding." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF051/document.

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La reconnaissance moléculaire est un problème très intéressant et surtout un défi actuel pour la chimie biophysique. Avoir des prévisions fiables sur la reconnaissance spécifique entre les molécules est hautement prioritaire, car il fournira un aperçu des problèmes fondamentaux et suscitera des applications technologiques pertinentes. La thèse présentée ici est centrée sur une analyse quantitatif de la reconnaissance moléculaire en solution pour la liaison l'hôte-invité, la liaison protéine-ligand et la catalyse. Le cadre de la mécanique statistique utilisé pour décrire l'état de la technique

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18

Su, Ruey-Chyi. "Major histocompatibility complex class I as a ligand for natural killer cell recognition." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0020/NQ53789.pdf.

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19

Mullin, Nicholas Paul. "Characterisation of ligand-binding to a carbohydrate-recognition domain of the macrophage mannose receptor." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320620.

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20

Tadayon, Roya [Verfasser], and Oliver [Akademischer Betreuer] Einsle. "Resolving the ligand-binding to pattern recognition receptor for advanced glycation end products (RAGE)." Freiburg : Universität, 2016. http://d-nb.info/115012427X/34.

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21

Deganutti, Giuseppe. "Ligand-receptor recognition events decoded at molecular scale by means of molecular dynamics simulations." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3421924.

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During the last decades, the technological evolution has been very fast and has paved the way to a wide set of theoretical approaches able to support and stimulate the experimental component of biological sciences. From this standpoint, in drug discovery and design, the ability to make working hypothesis on how a small molecule interacts with its biological target can lead to rational approaches for the developing of new drug candidates. Nowadays is possible to model the behaviour of chemical systems up to the atomistic scale, allowing retrieve insights on mechanisms behinds the ligand bindi

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22

Wong, Kar-ho. "Luminescent cyclometalated platinum(II) and gold(III) complexes for molecular recognition and DNA binding studies /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20357874.

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23

Ferrario, Maria Giovanna. "On the recognition of ecdysteroids by the ecdysone receptor : a computational study." Strasbourg, 2010. https://publication-theses.unistra.fr/restreint/theses_doctorat/2010/FERRARIO_Maria_Giovanna_2010.pdf.

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24

Salim, Mahboob. "Understanding the molecular basis of γδ T cell receptor ligand recognition in cellular stress surveillance". Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4537/.

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γδ T-cells are unconventional lymphocytes hypothesised to act at the interface between innate and adaptive immunity. Emerging evidence indicates γδ T-cells play important, nonredundant roles in lymphoid stress surveillance during infection and tumourigenesis, and γδ T-cell-focussed immunotherapy trials suggest their potential exploitation in cancer immunotherapy. However, the molecular basis of γδ TCR/ligand recognition is poorly understood. In this thesis I first focussed on ligand recognition by the LES TCR, which is derived from a Vδ2-negative T-cell and mediates TCR-dependent recognition o

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25

Schulte, Thorben Rüdiger. "Metal- and Ligand-Centered Chirality in Square-Planar Coordination Compounds." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://hdl.handle.net/21.11130/00-1735-0000-0005-126A-0.

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26

黃家豪 and Kar-ho Wong. "Luminescent cyclometalated platinum(II) and gold(III) complexes for molecular recognition and DNA binding studies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31221919.

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27

Grassein, Paul. "Simulation of receptor-ligand recognition mechanisms of human Glutahione Transferases by free energy landscape calculation : Applications to the science of taste and cancer." Thesis, Bourgogne Franche-Comté, 2019. http://www.theses.fr/2019UBFCK013.

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Les protéines hGSTs (Glutathions Transférases humaines) sont des enzymes qui jouent un rôle majeur dans la détoxification de notre organisme et qui sont impliquées dans le développement du cancer. Le mécanisme moléculaire par lesquel les hGSTs sélectionnent une grande diversité de ligands (médicaments, pesticides...) est incompris jusqu’à ce jour. Comprendre les mécanismes de reconnaissance ligand‐récepteur des hGSTs est un enjeu fondamental majeur aux implications sociétales et économiques fortes pour la recherche sur le cancer et pour les industries agroalimentaire et pharmaceutique (cf. pro

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28

Ferruz, Capapey Noelia 1988. "Understanding ligand-receptor recognition by means of high-throughput molecular dynamics : a perspective for drug discovery." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/363212.

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Understanding how receptor-ligand interactions occur is a first step towards designing new drugs. The complete reconstruction of the binding process in a drug-receptor system provides all the physical-chemistry variables for rational design of inhibitors of a chosen target, an important step in drug discovery. Although very powerful, direct experimental observation of full binding processes is very hard to perform. In this thesis, by using high-throughput molecular dynamics in the distributed computing project GPUGRID.net and analysing the resulting data by Markov state models (MSM), we succ

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29

Sjöström, Anna. "Dynamics of MHC class 1 recognition by natural killer cells - from receptor modulation to ligand acquisition /." Stockholm : [Karolinska institutets bibliotek], 2002. http://diss.kib.ki.se/2002/91-7349-204-3.

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30

Racys, Daugirdas. "Synthesis of multifunctional ensembles for asymmetric catalysis and chiral recognition : investigation of palladium-trost ligand complexes." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680110.

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The palladium complex 1, bearing the Trost 'Standard' Ligandi (TSL) 2 is an efficient and highly selective catalyst used to facilitate asymmetric allylic alkylation. Earlier research conducted by Lloyd Jones and co-workers suggested that the selectivity of the catalyst 1 monomeric species may arise via ligand-accelerated catalysis pathway. TSL 2 has a degree of flexibility that is crucial for the selectivity, but also responsible for the rapid equilibrium of the Pd-TSL monomers 1 with the low selectivity and diminished activity oligomers (I)n. The oligomers (I)n are known to be the dominant ca

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31

Simões, Inês Tadeu dos Anjos. "Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6582.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>The CD5 and CD6 lymphocyte surface receptors are highly homologous members of the Scavenger Receptor Cystein Rich (SRCR) superfamily mainly expressed by all T lymphocytes and the B1a subpopulation of B cells. Although the ultimate function/s are far from being completely understood, CD5 and CD6 are known to play a relevant role in both lymphocyte development and differentiation by negatively modulating the survival/death-inducing intracellular signals generated during the antigen recognition. Recently, this g

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32

Davis, Caroline M. "Investigation and Characterisation of Protein-Ligand Interactions: SRA-Ribonucleic Acid Recognition and Anti-Microbial Drug Discovery." University of Akron / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1437779075.

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33

McAtamney, Sarah. "Investigation of Dengue Fever Virus Envelope Glycoprotein Carbohydrate-Ligand Recognition Events Essential for Mammalian Cell Infection." Thesis, Griffith University, 2009. http://hdl.handle.net/10072/366363.

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Dengue Fever virus (DENV) is a very old mosquito-borne flavivirus that has made a modern worldwide re-emergence as a result of population movement and growth, urbanisation and lapse of vector control. The World Health Organisation estimates that 2.5 billion people, or two-fifths of the world’s population are at risk from DENV, which can cause serious illness and in its severe forms, death. Despite the humanitarian and economic burden that DENV and its flaviviral relatives create, there are no chemotherapeutic drugs available and vaccine development is challenging. Mammalian host cell infection

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34

Hanske, Jonas [Verfasser]. "Investigation of the Structural Basis of Ligand Recognition of the C-Type Lectin Receptor Langerin / Jonas Hanske." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1121587895/34.

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35

Dussart, Caitlyn. "Chiral self-recognition study of metallic complexes : towards coordination polymers." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAE006.

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Les assemblages polymériques métallo-supramoléculaires constituent une nouvelle classe de matériaux apparue au cours des dernières décennies. Ces matériaux présentent un large éventail de propriétés qui dépendent de la nature des métaux et des ligands ditopiques utilisés. La réversibilité des liaisons de coordination offre également un caractère dynamique au système qui peut répondre à un stimulus externe. En introduisant de la chiralité dans ces systèmes moléculaires, nous pouvons étudier la capacité de ces structures moléculaires à s’associer ou à se désolidariser pour former des espèces hom

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36

Dyachenko, Andrey. "Molecular recognition in gas phase: theoretical and experimental study of non-covalent protein-ligand complexes by mass-spectrometry." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/113301.

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In the present thesis we have explored different factors that impede accurate quantitative description of non-covalent protein-protein and protein-ligand interactions and design of new potent and specific binders from the scratch. Firstly, we addressed the role of solvent in the mechanism of non-covalent interactions. Secondly, we tackled the question about the intrinsic conformational flexibility of the protein molecules and the part it plays in weak interactions between proteins. In the first part of the thesis we studied the interactions of vascular endothelial growth factor (VEGF) prot

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37

Schafer, Jamie Lynn. "Rhesus macaque KIR recognition of MHC class I molecules: Ligand identification and modulation of interaction by SIV peptides." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11683.

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Natural killer (NK) cells can kill virus-infected cells without prior antigenic exposure, and are therefore important for controlling viral replication prior to the onset of adaptive immune responses. Primate NK cells express activating and inhibitory killer-cell immunoglobulin-like receptors (KIRs) that bind to specific major histocompatibility complex (MHC) class I molecules. The importance of KIR interactions with MHC class I in human immunodeficiency virus (HIV) pathogenesis is demonstrated by the association of select KIR and MHC class I genotypes with delayed progression to acquired immu

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38

Herbert, Paul. "The heteromeric 5-HT3A/B receptor : the effect of 5-HT3B subunits on receptor structure and ligand recognition." Thesis, Aston University, 2008. http://publications.aston.ac.uk/11070/.

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The 5-HT3 receptors are members of the cys-loop family of ligand-gated ion channels. Two functional subtypes are known, the homomeric 5HT3A and the heteromeric 5HT3A/B receptors, which exhibit distinct biophysical characteristics but are difficult to differentiate pharmacologically. Atomic force microscopy has been used to determine the stoichiometry and architecture of the heteromeric 5HT3A/B receptor. Each subunit was engineered to express a unique C-terminal epitope tag, together with six sequential histidine residues to facilitate nickel affinity purification. The 5-HT3 receptors, ectopica

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39

Sharma, Sumana. "Genome-scale identification of cellular pathways required for cell surface recognition." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/271825.

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A range of biochemically diverse molecules located in the plasma membrane— such as proteins, glycans, and lipids—mediate cellular recognition events, initiation of signalling pathways, and the regulation of processes important for the normal development and function of multicellular organisms. Interactions mediated by cell surface receptors can be challenging to detect in biochemical assays, because they are often highly transient, and membrane-embedded receptors are difficult to solubilise in their native conformation. The biochemical features of low-affinity extracellular protein interaction

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40

Schopis, Jia L. "Drug Discovery Studies of the T box Riboswitch: Potential Ligand Inhibition andCofactor Modulation of the tRNA-Antiterminator Complex Recognition." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1461674214.

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41

Pant, Pradeep. "Theoretical studies on the structure and dynamics of symmetric nucleic acids and recognition patterns in DNA- ligand/protein systems." Thesis, IIT Delhi, 2019. http://eprint.iitd.ac.in:80//handle/2074/8087.

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Ruiz, Botella Sheila. "The importance of ligand design for the development of supramolecular catalysts and ion receptors." Doctoral thesis, Universitat Jaume I, 2017. http://hdl.handle.net/10803/402550.

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La tesis está dividida en dos partes claramente diferenciadas. La primera parte trata sobre aspectos concernientes a la catálisis supramolecular. Los trabajos descritos están basados en el diseño de nuevos ligandos N-heterociclicos con diferentes topologías y funcionalidades, los cuales fueron coordinados a diferentes centros metálicos. Los complejos sintetizados fueron caracterizados y estudiados en catálisis, con el objetivo principal de estudiar los efectos producidos por los ligandos orgánicos debido a interacciones del tipo no covalentes. Estos complejos o catalizadores también fueron sop

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43

Pathak, Asmita. "Protection Against Atherosclerosis by A Non-native Pentameric CRP that Shares its Ligand Recognition Functions with an Evolutionarily Distant CRP." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3759.

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C-reactive protein (CRP) is an acute phase protein of the innate immune system that has been evolutionarily conserved. Human CRP is known to exist in two different pentameric conformations; native CRP and non-native CRP that possess differential ligand recognition functions. The structure of CRP evolved from arthropods to humans, in terms of subunit composition, disulfide bonds, and glycosylation pattern. Along with change in structure, the gene expression pattern of CRP also evolved from a constitutive protein in lower invertebrates to an acute phase protein in humans. The objective of this s

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44

Park, In-Hee. "Computational Simulations of Protein-Ligand Molecular Recognition via Enhanced Samplings, Free Energy Calculations and Applications to Structure-Based Drug Design." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1276745410.

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45

Nutiu, Razvan Li Yingfu. "Fluorescent functional DNA for bioanalysis, drug discovery and nanotechnology." *McMaster only, 2006.

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46

Wiesner, Silke. "NMR studies of the yeast splicing factor Prp40 structures and ligand recognition of a WW domain pair and an FF domain /." [S.l. : s.n.], 2003. http://www.diss.fu-berlin.de/2003/66/index.html.

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47

Frieg, Benedikt [Verfasser], and Birgit [Gutachter] Strodel. "Integrative modeling of function-associated molecular recognition in protein-ligand, protein-peptide, and protein-protein complexes / Benedikt Frieg ; Gutachter: Birgit Strodel." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2020. http://d-nb.info/1203872445/34.

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48

Patschull, Lafitte-Laplace Anathe Olivia Maria. "In silico ligand fitting/docking, computational analysis and biochemical/biophysical validation for protein-RNA recognition and for rational drug design in diseases." Thesis, Birkbeck (University of London), 2014. http://bbktheses.da.ulcc.ac.uk/84/.

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Kaposi’s sarcoma-associated herpesvirus, is a double-stranded DNA γ - herpesvirus and the main causative agent of Kaposi’s sarcoma (KS). γ - herpesviruses undergo both lytic and latent replication cycles; and encode proteins that modulate host transcription at the RNA level, by inducing decay of certain mRNAs. Here we describe a mechanism that allows the viral endo-/exonuclease SOX to recognise mRNA targets on the basis of an RNA motif and fold. To induce rapid RNA degradation by subverting the main host mRNA degradation pathway SOX was shown to directly bind Xrn1. This may shed light as to ho

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Carmo, dos Santos Nadia A. "Syntheses and application of nitrogen based polydentate ligand complexes." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3427281.

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This Ph.D. thesis describes the versatility of metal complexes with tris(2-pyridylmethyl)amine (TPMA) based ligands to be used either as self-assembling molecular scaffolds with application on molecular recognition and chiroptical probing, or as active catalysts in atom transfer radical polymerization and hydrogen evolving catalysis reactions. Quantitative chirality determination is fundamental due to the broad effect that stereochemistry has in many different scientific fields. Within this subject, there is a strong urge to develop fast and effective methods to perform stereochemical analysis

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Boissieras, Joseph. "Étude des interactions de ligands et d'anticorps avec les i-motifs de l'ADN." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF080.

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Les i-motifs sont des structures tétramériques d'ADN constituées de paires de bases CH+:C intercalées et qui peuvent se former dans des séquences d'ADN riches en cytosine, notamment dans les conditions légèrement acides (pH≈6,0) où certaines cytosines seront protonées. Bien qu'elles soient connues depuis plus de 30 ans, du fait de leur forte dépendance au pH ces structures ont longuement été considérées comme uniquement présentes in vitro. Plus récemment, en 2018, un anticorps iMab a été développé pour cibler les i-motifs et les études ont suggéré leur présence au niveau cellulaire. De nombreu

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