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Rozprawy doktorskie na temat „Lipid Droplet”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 26 lipca 2025

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1

Deeney, Jude T. "Micro lipid droplet precursors of milk lipid globules." Thesis, Virginia Tech, 1985. http://hdl.handle.net/10919/45673.

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The lipid in milk (milk fat) is found in the form of droplets known as milk lipid globules (MLG). These milk lipid globules are encompassed by a unit membrane known as the milk lipid globule membrane (MLGM) which is derived from the apical plasma membrane of the mammary epithelial cell during secretion. In lactating mammary epithelial cells, immediate precursors of milk lipid globules appear to be cytoplasmic lipid droplets (CLD). These cytoplasmic lipid droplets have diameters >1 μm and are characterized by an electron dense, granular surface coat. A previously unrecognized group of

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Krahmer, Natalie. "Analysis of Lipid Droplet Proteins and their Contribution to Phospholipid Homeostasis during Lipid Droplet Expansion." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-133305.

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Danial, John Shokri Hanna. "Imaging lipid phase separation on droplet interface bilayers." Thesis, University of Oxford, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711943.

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Du, Xiaoli [Verfasser]. "Characterization of Lipid Droplets and Functional Analysis of Lipid Droplet-Associated Proteins in Dictyostelium discoideum / Xiaoli Du." Kassel : Universitätsbibliothek Kassel, 2013. http://d-nb.info/1038246776/34.

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Grachan, Jeremy J. "Characterization of Hypoxia-Inducible Lipid Droplet Associated Protein (HILPDA) Dependent Lipid Droplet Abundance in Pancreatic Cancer Tumors Cells." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586437335477715.

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Krahmer, Natalie [Verfasser], and Stefan [Akademischer Betreuer] Jentsch. "Analysis of Lipid Droplet Proteins and their Contribution to Phospholipid Homeostasis during Lipid Droplet Expansion / Natalie Krahmer. Betreuer: Stefan Jentsch." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1015170366/34.

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Danial, John Shokri Hanna. "Imaging lipid phase separation in droplet interface bilayers." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:34bb015f-2bc1-43bb-bc29-850e0b55edac.

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The spatiotemporal organization of membrane proteins is implicated in cellular trafficking, signalling and reception. It was proposed that biological membranes partition into lipid rafts that can promote and control the organization of membrane proteins to localize the mentioned processes. Lipid rafts are thought to be transient (microseconds) and small (nanometers), rendering their detection a challenging task. To circumvent this problem, multi-component artificial membrane systems are deployed to study the segregation of lipids at longer time and length scales. In this thesis, multi-componen

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McClinchie, Elizabeth A. "Homologs of Mammalian Lysosomal Lipase in Arabidopsis and Their Roles in Lipid Droplet Dynamics." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc1062826/.

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Lipid droplets (LDs) are organelles with many functions in cells and numerous protein interactors facilitate their biogenesis, maintenance, and turnover. The mammalian lipase responsible for LD turnover during lipophagy, LipA, has two candidate homologs in Arabidopsis: MPL1 and LIP1. One or both of these plant homologs may function in a similar manner to mammalian LipA, providing an LD breakdown pathway. To test this hypothesis, wild type (WT) Arabidopsis plants, MPL1 over-expressing (OE) mutants, and T-DNA insertion mutants of MPL1 (mpl1) and LIP1 (lip1) were examined for LD phenotypes in no

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9

Beller, Mathias. "Identification and characterization of Drosophila lipid droplet-associated proteins." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974177822.

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Nicolaou, Giovanna. "Mechanisms of bacteria-mediated lipid droplet formation in macrophages." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/28530.

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Atherosclerosis is a chronic inflammatory disease of the arteries that represents the root cause of the majority of heart attacks and strokes. The accumulation of lipid droplets (LDs) in macrophages and their subsequent transformation into foam cells is one of the key steps in the development of atherosclerotic lesions. It has been traditionally thought that this process is largely dependent on the accumulation of oxidised low-density lipoprotein (OxLDL) via uptake by macrophage scavenger receptors. However, as DNA signatures from a wide array of bacterial species have been identified in human

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Punnamaraju, Srikoundinya. "Voltage and Photo Induced Effects in Droplet-Interface-Bilayer Lipid Membranes." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1321648604.

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Vanderwerker, Zachary Thomas. "Using Lipid Bilayers in an Artificial Axon System." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/24449.

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Since the rise of multicellular organisms, nature has created a wide range of solutions for life on Earth. This diverse set of solutions presents a broad design space for a number of bio-inspired technologies in many different fields. Of particular interest for this work is the computational and processing power of neurons in the brain. Neuronal networks for transmitting and processing signals have advantages to their electronic counterparts in terms of power efficiency and the ability to handle component failure. In this thesis, an artificial axon system using droplet on hydrogel bilayers

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Rathnayake, Sewwandi S. "A BIOPHYSICAL CHARACTERIZATION OF PROTEIN-LIPID INTERACTIONS OF THE LIPID DROPLET BINDING PROTEIN, PERILIPIN 3." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1469552680.

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Johnsen, Lisa 1987. "Lipid droplet regulation by the differentially spliced proteins Osw5L and Osw5S." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/565566.

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Epithelial tissues undergo extensive remodeling during embryonic development. Recent studies have revealed that, in a number of developmental processes, epithelial remodeling is associated with pulsations of individual cell surface areas and cortical actomyosin flows. During Drosophila dorsal closure, the amnioserosa (AS), a contractile tissue covering the dorsal region of the embryo, shows contractile pulsations and regular actomyosin flows during the reduction of its apical surface area. The biophysical mechanism driving these shape pulsations as well as the role of contractile actomyosin w

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15

Siddiqah, Ikha M. "Yeast Env9 is a conserved oxidoreductase involved in lipid droplet biogenesis." Thesis, California State University, Long Beach, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1593799.

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<p> Baker’s yeast serves as an ideal model to study endomembrane system due to high conservation of its regulation and trafficking between yeast and human. <i>ENV9</i> is a novel gene involved in vesicular trafficking in <i>Saccharomyces cerevisiae.</i> Previous characterization by our laboratory established that <i>ENV9</i> deletion leads to lysosomal defects and that Env9 is localized to lipid droplets (LDs). Our bioinformatics studies show that <i>ENV9</i> is conserved among eukaryotes and is an orthologue of human Retinol Dehydrogenase 12 (<i> RDH12</i>). </p><p> In this study, we

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16

LIU, KUN. "Defining the Roles of FSP27 in Lipid Droplet Formation and Apoptosis." University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1277820858.

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Wason, Sundeep Joshua. "The role of Annexin A6 in lipid droplet formation of hepatocytes." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/20148.

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Non-alcoholic fatty liver disease (NAFLD) and Type 2 diabetes mellitus (T2DM) are hallmarks of the metabolic syndrome. Neutral lipid accumulation in lipid droplets (LDs) contributes to the development of fatty liver and NAFLD. Together with insulin resistance and inflammation, this often leads to liver failure or hepatocarcinoma. Current treatments have limitations and identification of new targets that contribute to triglyceride accumulation and LD formation are urgently needed. Over the years, Grewal and colleagues have intensively studied Annexin A6 (AnxA6), a calcium (Ca2+) and membrane bi

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Horn, Patrick J., Christopher N. James, Satinder K. Gidda, et al. "Identification of a New Class of Lipid Droplet-Associated Proteins in Plants." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/4752.

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Lipid droplets in plants (also known as oil bodies, lipid bodies, or oleosomes) are well characterized in seeds, and oleosins, the major proteins associated with their surface, were shown to be important for stabilizing lipid droplets during seed desiccation and rehydration. However, lipid droplets occur in essentially all plant cell types, many of which may not require oleosin-mediated stabilization. The proteins associated with the surface of nonseed lipid droplets, which are likely to influence the formation, stability, and turnover of this compartment, remain to be elucidated. Here, we hav

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19

Young, Taylor Tront. "Lipid Bilayer Formation in Aqueous Solutions of Ionic Liquids." Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/35292.

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The formation of lipid bilayer membranes between droplets of ionic liquid is presented as a means of forming functional bimolecular networks for use in sensor applications. Ionic liquids are salts that have a number of useful properties, such as low melting points making them liquid at room temperature and exceedingly low vapor pressure. Ionic liquids have seen recent popularity as environmentally friendly industrial solvent alternatives. Our research demonstrates that it is possible to consistently form lipid bilayers between droplets of ionic liquid solutions. Analysis shows that the ionic

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20

DiStefano, Marina T. "A Role for the Lipid Droplet Protein HIG2 in Promoting Lipid Deposition in Liver and Adipose Tissue: A Dissertation." eScholarship@UMMS, 2016. http://escholarship.umassmed.edu/gsbs_diss/830.

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Chronic exposure of humans or rodents to high calorie diets leads to hypertriglyceridemia and ectopic lipid deposition throughout the body, resulting in metabolic disease. Cellular lipids are stored in organelles termed lipid droplets (LDs) that are regulated by tissue-specific LD proteins. These proteins are critical for lipid homeostasis, as humans with LD protein mutations manifest metabolic dysfunction. Identification of novel components of the LD machinery could shed light on human disease mechanisms and suggest potential therapeutics for Type 2 Diabetes. Microarray analyses pinpointed th

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Cheung, W. K. S. "Rotavirus inclusion bodies ('viroplasms') are structurally and functionally associated with lipid droplet components." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597592.

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Rotaviruses are a leading cause of acute gastroenteritis in infants and young children worldwide and possess a genome of 11 double-stranded (ds) RNA segments. Early morphogenesis of RV particles and viral RNA replication occur in cytoplasmic inclusion bodies called ‘viroplasms’, of which the viral non-structural proteins NSP2 and NSP5 are essential components. Using confocal microscopy (CM), we demonstrated association of viroplasms with lipids and lipid droplet (LD)-associated proteins (perilipin A, ADRP). LD-associated proteins were found to co-localise with viroplasm-like structures (VLS) i

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Edgerton, Alexander James. "Design and Testing of a Hydrogel-Based Droplet Interface Lipid Bilayer Array System." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/56894.

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The research presented in this thesis includes the development of designs, materials, and fabrication processes and the results of characterization experiments for a meso-scale hydrogel-based lipid bilayer array system. Two design concepts are investigated as methods for forming Droplet Interface Bilayer (DIB) arrays. Both concepts use a base of patterned silver with Ag/AgCl electrodes patterned onto a flat polymer substrate. In one technique, photopolymerizable hydrogel is cured through a mask to form an array of individual hydrogels on top of the patterned electrodes. The other technique int

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23

Kharabi, Masouleh Schekufe [Verfasser]. "Lipid droplet formation drives pathogenic ILC2 responses in airway inflammation / Schekufe Kharabi Masouleh." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1218301783/34.

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Gutierrez, Esteban [Verfasser]. "A role of Alzheimer’s disease-associated γ-secretase in lipid metabolism and lipid droplet formation via LXR activation / Esteban Gutierrez". Bonn : Universitäts- und Landesbibliothek Bonn, 2021. http://d-nb.info/1239729944/34.

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Villar, Gabriel. "Aqueous droplet networks for functional tissue-like materials." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:602f9161-368c-48c0-9619-7974f743f2f2.

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An aqueous droplet in a solution of lipids in oil acquires a lipid monolayer coat, and two such droplets adhere to form a bilayer at their interface. Networks of droplets have been constructed in this way that function as light sensors, batteries and electrical circuits by using membrane proteins incorporated into the bilayers. However, the droplets have been confined to a bulk oil phase, which precludes direct communication with physiological environments. Further, the networks typically have been assembled manually, which limits their scale and complexity. This thesis addresses these limitat

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Najem, Joseph Samih. "Droplet Interface Bilayers for Mechano-Electrical Transduction Featuring Bacterial MscL Channels." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/83399.

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This dissertation investigates the behavior of the Escherichia Coli mechanosensitive (MS) channel MscL, when incorporated within a droplet interface bilayer (DIB). The activity of MscL channels in an artificial DIB system is demonstrated for the first time in this document. The DIB represents a building block whose repetition can form the basis to a new class of smart materials. The corresponding stimuli-responsive properties can be controlled by the type of biomolecule incorporated into the lipid bilayer, which is in the heart of this material. In the past decade, many research groups have pr

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Lohmann, Daniel [Verfasser]. "Posttranslational modifications of Ancient Ubiquitous Protein 1 control intracellular Lipid Droplet clustering / Daniel Lohmann." Bonn : Universitäts- und Landesbibliothek Bonn, 2013. http://d-nb.info/1052061028/34.

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Girard, Victor. "Understanding lipid droplet biogenesis in the central nervous system of Drosophila models of Parkinson's disease." Thesis, Lyon, 2020. http://www.theses.fr/2020LYSEN083.

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Les maladies neurodégénératives sont l’une des principales causes d’invalidité dans le monde. Certaines de ces maladies, telle que la maladie de Parkinson (MP), sont associées à des dérégulations du métabolisme lipidique. En effet, plusieurs laboratoires dont le nôtre, ont montré que l’accumulation d’acide gras sous forme de gouttelettes lipidiques (GLs) dans les cellules gliales est un mécanisme de réponse au stress oxydatif conservé au cours de l’évolution. De plus, la formation de GLs dans les neurones pourrait aussi participer au processus neurodégénératif. La contribution respective des c

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Nagarajan, Shilpa. "Role Of The Lipid Droplet Proteome In The Pathogenesis Of Insulin Resistance In The Liver." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20273.

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Non-alcoholic fatty liver (NAFL) disease is defined by the accumulation of intrahepatic triglycerides stored in metabolically active lipid droplets (LDs). LD-associated proteins that participate in lipolysis have been of interest in elucidating the pathogenesis of IR in NAFL; however, gain- and loss- of function studies of these regulators have provided largely contradictory results. Moreover, little is known about the influence of insulin action on the proteome, phosphoproteome and ubiquitome within NAFL. Therefore, the aim of this project was to quantify high-fat diet and insulin-sensitive c

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Fontaine, Florent. "Functional study of Lipid Droplet (LD) addressing domains to improve the purification of recombinant proteins." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASB004.

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La production de protéines recombinantes hydrophobes, telles que les protéines transmembranaires, est complexe en raison de leur association avec des environnements lipidiques, rendant leur purification coûteuse et difficile, représentant jusqu'à 80 % des coûts de production. Cette thèse propose une approche innovante exploitant les propriétés des gouttelettes lipidiques (GLs) végétales pour faciliter le repliement et la purification par flottaison de protéines hydrophobes, via un ancrage par l'oléosine AtOLE1, protéine majeure des GLs de graines. Si cette méthode a été validée pour des protéi

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Kang, Sun Woo. "The maintenance of lipid droplet and energy homeostasis and the impact of ageing during hepatocyte polarization." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20246.

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Hepatocytes have a well-defined polarized morphological structure. Establishment and maintenance of polarity is crucial for the function and viability of hepatocytes. Many disorders, both genetic and acquired, and drugs can impair polarization resulting in liver dysfunction and injury. Hepatocyte polarization is an energy-dependent process. Hence, cellular energy metabolism can significantly affect the polarized morphology and function of hepatocytes. An in vitro study has shown that there were diminishing numbers of lipid droplets in correlation to increased autophagy, ATP levels and mitocho

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González, Cabodevilla Ainara. "Lipid droplet biogenesis: a novel process of self-digestion as a strategy of survival to stress." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/287913.

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Las gotas lipídicas (lipid droplets, LD) son orgánulos presentes en la mayor parte de las células eucarióticas. Están compuestas por un núcleo hidrofóbico de triacilglicéridos y ésteres de colesterol, rodeado por una monocapa de fosfolípidos a la que se asocian proteínas específicas.El interés despertado por las LD ha aumentado en los últimos años, debido a su implicación en patologías. En algunos casos, el número y el tamaño de las LD es anormalmente alto, como ocurre en los hepatocitos en el hígado esteatótico o en los macrófagos de las placas ateroscleróticas. Existen también evidencias que

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Ouimet, Mireille. "Regulation of Lipid Droplet Cholesterol Efflux from Macrophage Foam Cells: a Role for Oxysterols and Autophagy." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20399.

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Macrophage foam cells are the major culprits in atherosclerotic lesions, having a prominent role in both lesion initiation and progression. With atherosclerosis being the main factor underlying cardiovascular complications, there is a long-standing interest on finding ways to reverse lipid buildup in plaques. Studies have shown that promoting reverse cholesterol transport (RCT) from macrophage foam cells is anti-atherogenic because it alleviates the cholesterol burden of the plaques. The goal of this thesis was to gain insight into the mechanisms that govern cholesterol efflux from macrophage

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Schnell, David M. "VITAMIN D WORKS THROUGH THE LIPID DROPLET PROTEIN PLIN2 TO AUGMENT MITOCHONDRIAL FUNCTION IN SKELETAL MUSCLE." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacol_etds/23.

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Vitamin D has been connected with increased intramyocellular lipid (IMCL) mitochondrial function in skeletal muscle. It is also shown to prevent lipotoxicity in several tissues, but this has not yet been examined in skeletal muscle. Perilipin 2 (PLIN2), a lipid droplet protein upregulated with vitamin D treatment, is integral to managing IMCL capacity and lipid oxidation in skeletal muscle. Increased lipid storage and oxidation is associated with increased tolerance to a hyperlipidic environment and resistance to lipotoxicity. Therefore, I hypothesized that vitamin D increases β-oxidation and

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Gidda, Satinder K., Samantha C. Watt, Jillian Collins-Silva, et al. "Lipid Droplet-Associated Proteins (ldaps) Are Involved in the Compartmentalization of Lipophilic Compounds in Plant Cells." Digital Commons @ East Tennessee State University, 2013. https://doi.org/10.4161/psb.27141.

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While lipid droplets have traditionally been considered as inert sites for the storage of triacylglycerols and sterol esters, they are now recognized as dynamic and functionally diverse organelles involved in energy homeostasis, lipid signaling, and stress responses. Unlike most other organelles, lipid droplets are delineated by a half-unit membrane whose protein constituents are poorly understood, except in the specialized case of oleosins, which are associated with seed lipid droplets. Recently, we identified a new class of lipid-droplet associated proteins called LDAPs that localize specifi

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Landry, Chandra. "Phosphatidylcholine Metabolism and ACAT Affect the Trafficking of LDL-derived Free Cholesterol in Cholesterol-loaded CHO Cells." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23087.

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In vitro studies have shown that the major membrane phospholipid phosphatidylcholine (PC) can positively influence the incorporation of cholesterol in lipid membranes. The influence of PC on the cellular trafficking of LDL-derived free cholesterol was investigated. Sterol regulatory-defective (SRD)-4 cells are Chinese hamster ovary (CHO)-derived fibroblasts that display vastly elevated rates for the synthesis and catabolism of PC. SRD-4 cells harbor two known gene mutations: a mutation in the functional allele for SCAP, resulting in defective feedback suppression of cholesterol biosynthesis;

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Mensah, Lawrence B. "Regulation of lipid droplet formation, mitochondrial integrity and motor functions by insulin and TOR signalling in drosophila." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669996.

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Russell, Tanya D. "PAT protein regulation of cytoplasmic lipid droplet formation and secretion : role of adipophilin in mammary epithelial cells /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Molecular Biology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 134-149). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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Wong, Christine Shiang Yee. "Study on lipid droplet dynamics in live cells and fluidity changes in model bacterial membranes using optical microscopy techniques." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/8842.

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In this thesis optical microscopy techniques are used to consider aspects of viral and bacterial infections. In part 1, the physical effects of cytomegalovirus on lipid droplet dynamics in live cells are studied; in part 2, the effects of an antimicrobial peptide on the fluidity of model bacterial membranes are studied. The optical microscopy techniques used to study the effects of murine-cytomegalovirus (mCMV) on lipid droplets in live NIH/3T3 fibroblast cells in real-time are coherent anti- Stokes Raman scattering (CARS), two-photon fluorescence (TPF) and differential interference contrast (

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Creasy, Miles Austin. "Bilayer Network Modeling." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/28758.

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This dissertation presents the development of a modeling scheme that is developed to model the membrane potentials and ion currents through a bilayer network system. The modeling platform builds off of work performed by Hodgkin and Huxley in modeling cell membrane potentials and ion currents with electrical circuits. This modeling platform is built specifically for cell mimics where individual aqueous volumes are separated by single bilayers like the droplet-interface-bilayer. Applied potentials in one of the aqueous volumes will propagate through the system creating membrane potentials across

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Duca, Edward. "Invadolysin, a conserved lipid droplet-associated protease interacts with mitochondrial ATP synthase and regulates mitochondrial metabolism in Drosophila." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5562.

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Invadolysin (inv) is a member of the M8 class of zinc-metalloproteases and is conserved throughout metazoans. It is essential for development and invadolysin homozygous Drosophila mutants are third instar larval lethal. These larvae exhibit a reduced larval brain size and an absence of imaginal discs. Detailed analysis showed that inv mutants exhibit pleiotropic effects, including defects with chromosome architecture, cell cycle progression, spindle assembly, nuclear envelope dynamics, protein turnover and problems with germ cell migration. These findings indicated that Invadolysin must have a

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Palgunow, Daniela [Verfasser]. "Influence of dietary restriction on body composition, lipid droplet size and gene expression in Caenorhabditis elegans / Daniela Palgunow." Kiel : Universitätsbibliothek Kiel, 2012. http://d-nb.info/102929352X/34.

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Cai, Yingqi. "Lipogenic Proteins in Plants: Functional Homologues and Applications." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1404563/.

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Although cytoplasmic lipid droplets (LDs) are the major reserves for energy-dense neutral lipids in plants, the cellular mechanisms for packaging neutral lipids into LDs remain poorly understood. To gain insights into the cellular processes of neutral lipid accumulation and compartmentalization, a necessary step forward would be to characterize functional roles of lipogenic proteins that participate in the compartmentalization of neutral lipids in plant cells. In this study, the lipogenic proteins, Arabidopsis thaliana SEIPIN homologues and mouse (Mus Musculus) fat storage-inducing transmembra

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Giménez, Andrés Manuel. "Interaction of perilipin amphipathic helices with lipid droplets The Many Faces of Amphipathic Helices A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL006.

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Les gouttelettes lipidiques (LDs) sont des réservoirs d'énergie et des compartiments membranaires. Elles sont composées d'un noyau des lipides neutres et d'une monocouche de phospholipides associées à des protéines. Les hélices amphipathiques (AHs), sont des structures protéiques secondaires qui interagissent avec les membranes des organelles. La manière dont les AHs interagissent avec la surface des LDs reste largement méconnue. Les périlipines sont une famille de protéines abondantes dans les LDs. Elles utilisent les AHs pour cibler les LDs. Certains de leurs membres ont des fonctions bien d

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Thiel, Katharina [Verfasser], Mathias [Akademischer Betreuer] Beller, Herbert [Akademischer Betreuer] Jäckle, and Gregor [Akademischer Betreuer] Bucher. "Charakterisierung von Lipid-droplet-Regulatoren der Fruchtfliege Drosophila melanogaster / Katharina Thiel. Gutachter: Herbert Jäckle ; Gregor Bucher. Betreuer: Mathias Beller." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1042846197/34.

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Wallstab, Christin. "Mathematische Modellierung der Dynamik von Lipidtropfen in Leberzellen." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2017. http://dx.doi.org/10.18452/17738.

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Diese Dissertation befasst sich mit der Dynamik von Lipidtropfen (LDs), die der Speicherung von Lipiden (hauptsächlich Triacylglycerol, TAG) dienen. Das epidemische Auftreten von Adipositas und der sogenannten Fettleber (Steatose) hat das wissenschaftliche Interesse an der Regulation der zellulären Speicherung in LDs stark beflügelt. Es gibt inzwischen zahlreiche Publikationen zu einzelnen Aspekten der Bildung, des Wachstums und des Abbaus von Lipidtropfen. Ein detailliertes mathematisches Modell, das diese Einzelergebnisse in ein konsistentes Bild zusammenfügt, gibt es allerdings nicht. Die A

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Bamji-Mirza, Michelle. "Defining an Intracellular Role of Hepatic Lipase in the Formation of Very Low Density Lipoproteins and High Density Lipoproteins." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20134.

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Hepatic lipase (HL) plays a pivotal role in the catabolism of apolipoprotein (apo)B-containing lipoproteins and high density lipoprotein (HDL) particles through its reported catalytic and non-catalytic extracellular functions. The current study tested the hypothesis that HL expression might impair formation and secretion of hepatic derived very low density lipoproteins (VLDL) and apoA-I (nascent HDL). Stable or transient expression of human HL (hHL) in McA-RH7777 cells resulted in decreased incorporation of [3H]glycerol into cell-associated and secreted (VLDL-associated) 3H-triacylglcyerol (TA

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Frost, Sarah. "Functional significance of Tumor Protein D52 amplification and overexpression in cancer." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18817.

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Tumor Protein D52 (TPD52) is an oncogene whose overexpression has been demonstrated in tumours of diverse cellular origins and associated with poor prognosis. Although the breadth and clinical significance of TPD52 overexpression in cancer is now well-established, there remains a long-standing deficit in our understanding of its functional significance. TPD52 is located on the frequently gained chromosome band 8q21, where we propose that it is an amplification target. We analysed TPD52 amplification in 995 cancer cell lines and then investigated whether this was broadly associated with altered

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Sander, Simone [Verfasser], and Britta [Akademischer Betreuer] Brügger. "Relevance of ACSL3-mediated ACS activity and ACSL3 localization in anabolic and catabolic lipid droplet metabolism / Simone Sander ; Betreuer: Britta Brügger." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1177695626/34.

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Gross, Linda C. M. "Applications of droplet interface bilayers : specific capacitance measurements and membrane protein corralling." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:0b7ffba6-b86d-499c-a93f-3b2fc46a427b.

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Droplet Interface Bilayers (DIBs) have a number of attributes that distinguish them from conventional artificial lipid bilayers. In particular, the ability to manipulate bilayers mechanically is explored in this thesis. Directed bilayer area changes are used to make precise measurements of the specific capacitance of DIBs and to control the two dimensional concentration of a membrane protein reconstituted in the bilayer. Chapter 1 provides a general introduction to the role of the lipid membrane en- vironment in the function of biological membranes and their integral proteins. An overview of m

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