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Artykuły w czasopismach na temat „Lipidic model membranes”

Autor: Grafiati

Data publikacji: 1 lutego 2025

Data aktualizacji: 31 lipca 2025

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1

Le Goff, Thomas, Tung B. T. To, and Olivier Pierre-Louis. "Shear dynamics of confined membranes." Soft Matter 17, no. 22 (2021): 5467–85. http://dx.doi.org/10.1039/d1sm00322d.

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Inspired by biolubrication, we model the nonlinear dynamics of lipidic membranes sheared between two walls. Several regimes are found with different wrinkle patterns, leading to a non-monotonous contribution of the membrane to the friction force.

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Sejwal, Kushal, Mohamed Chami, Paul Baumgartner, Julia Kowal, Shirley A. Müller, and Henning Stahlberg. "Proteoliposomes – a system to study membrane proteins under buffer gradients by cryo-EM." Nanotechnology Reviews 6, no. 1 (2017): 57–74. http://dx.doi.org/10.1515/ntrev-2016-0081.

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AbstractMembrane proteins are vital to life and major therapeutic targets. Yet, understanding how they function is limited by a lack of structural information. In biological cells, membrane proteins reside in lipidic membranes and typically experience different buffer conditions on both sides of the membrane or even electric potentials and transmembrane gradients across the membranes. Proteoliposomes, which are lipidic vesicles filled with reconstituted membrane proteins, provide an ideal model system for structural and functional studies of membrane proteins under conditions that mimic nature

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Brémaud, Erwan, Cyril Favard, and Delphine Muriaux. "Deciphering the Assembly of Enveloped Viruses Using Model Lipid Membranes." Membranes 12, no. 5 (2022): 441. http://dx.doi.org/10.3390/membranes12050441.

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The cell plasma membrane is mainly composed of phospholipids, cholesterol and embedded proteins, presenting a complex interface with the environment. It maintains a barrier to control matter fluxes between the cell cytosol and its outer environment. Enveloped viruses are also surrounded by a lipidic membrane derived from the host-cell membrane and acquired while exiting the host cell during the assembly and budding steps of their viral cycle. Thus, model membranes composed of selected lipid mixtures mimicking plasma membrane properties are the tools of choice and were used to decipher the firs

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4

Wrobel, Dominika, Dietmar Appelhans, Marco Signorelli, et al. "Interaction study between maltose-modified PPI dendrimers and lipidic model membranes." Biochimica et Biophysica Acta (BBA) - Biomembranes 1848, no. 7 (2015): 1490–501. http://dx.doi.org/10.1016/j.bbamem.2015.03.033.

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Castelli, Francesco, Sebastiana Caruso, and Nicola Uccella. "Biomimesis of Linolenic Acid Transport through Model Lipidic Membranes by Differential Scanning Calorimetry." Journal of Agricultural and Food Chemistry 51, no. 4 (2003): 851–55. http://dx.doi.org/10.1021/jf020582z.

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Gallová, J., K. Želinská, and P. Balgavý. "Partial molecular volumes of cholesterol and phosphatidylcholine in mixed bilayers." European Pharmaceutical Journal 64, no. 2 (2017): 1–3. http://dx.doi.org/10.1515/afpuc-2017-0012.

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Abstract Dispersion of multilamellar liposomes of dimyristoylphosphatidylcholine (DMPC) and cholesterol (CHOL) were studied by vibrational densitometer for the CHOL mole fractions X = 0−0.54 in the temperature range 18−50 °C, both below and above the main phase transition. DMPC-CHOL bilayers served as a simple model for lipidic part of biological membrane. Volumetric parameters are essential not only to evaluate the data obtained by scattering and diffraction methods on model membranes but can provide valuable information about molecular packing in bilayers and the phase behaviour of lipid-CHO

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Parra, Elisa, Lara H. Moleiro, Ivan López-Montero, Antonio Cruz, Francisco Monroy, and Jesús Pérez-Gil. "A combined action of pulmonary surfactant proteins SP-B and SP-C modulates permeability and dynamics of phospholipid membranes." Biochemical Journal 438, no. 3 (2011): 555–64. http://dx.doi.org/10.1042/bj20110681.

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Proteins SP-B and SP-C are essential to promote formation of surface-active films at the respiratory interface, but their mechanism of action is still under investigation. In the present study we have analysed the effect of the proteins on the accessibility of native, quasi-native and model surfactant membranes to incorporation of the fluorescent probes Nile Red (permeable) and FM 1-43 (impermeable) into membranes. We have also analysed the effect of single or combined proteins on membrane permeation using the soluble fluorescent dye calcein. The fluorescence of FM 1-43 was always higher in me

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8

Trombetta, Domenico, Francesco Castelli, Maria Grazia Sarpietro, et al. "Mechanisms of Antibacterial Action of Three Monoterpenes." Antimicrobial Agents and Chemotherapy 49, no. 6 (2005): 2474–78. http://dx.doi.org/10.1128/aac.49.6.2474-2478.2005.

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ABSTRACT In the present paper, we report the antimicrobial efficacy of three monoterpenes [linalyl acetate, (+)menthol, and thymol] against the gram-positive bacterium Staphylococcus aureus and the gram-negative bacterium Escherichia coli. For a better understanding of their mechanisms of action, the capability of these three monoterpenes to damage biomembranes was evaluated by monitoring the release, following exposure to the compounds under study, of the water-soluble fluorescent marker carboxyfluorescein from unilamellar vesicles with different lipidic compositions (phosphatidylcholine, pho

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9

Castanho, M. A. R. B., S. Lopes, and M. Fernandes. "Using UV-Vis. Linear Dichroism to Study the Orientation of Molecular Probes and Biomolecules in Lipidic Membranes." Spectroscopy 17, no. 2-3 (2003): 377–98. http://dx.doi.org/10.1155/2003/801452.

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Linear dichroism methodologies are based on the different interaction of molecules with linearly polarized light depending on their orientation. Theoretical predictions are used to conclude on the orientation of selected molecules relative to their neighbours (usually an organized matrix). In the specific case of linear dichroism methodologies applied to data obtained from UV-Vis. spectroscopic techniques, the orientational distribution function of the chromophores' electronic transition moment can be calculated and converted to the molecular axis distribution function. In this paper, the orie

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10

Mori, Kenichi, Yosuke Imai, Tsubasa Takaoka, Koji Iwamoto, Hideyoshi Fuji, and Tyuji Hoshino. "2P270 Database of Lipid Membrane Structures : Computational Analyses of Model Membranes(40. Membrane structure,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)." Seibutsu Butsuri 46, supplement2 (2006): S363. http://dx.doi.org/10.2142/biophys.46.s363_2.

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Han, Xu, Chih-Chia Su, Zhemin Zhang, Meinan Lyu, Edward Yu та Marvin T. Nieman. "Elucidating the Structural Dynamics of Integrin α IIbβ 3 from Native Platelet Membranes By Cryo-EM Coupled with Build and Retrieve Data Processing Methodology". Blood 142, Supplement 1 (2023): 2559. http://dx.doi.org/10.1182/blood-2023-178888.

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Background: Platelets play a critical role in physiological processes by sensing the extracellular environment through their membrane proteins. Changing the quantity or quality of these proteins can profoundly affect platelet physiology and impact health. The native membrane environment provides essential additional regulatory cues that impact the protein structure and mechanism of action. Single-particle cryogenic electron microscopy (cryo-EM) has transformed structural biology by allowing high-resolution structures of membrane proteins and large macromolecules to be solved from highly purifi

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12

Speziale, Chiara, Livia Salvati Manni, Cristina Manatschal, Ehud M. Landau, and Raffaele Mezzenga. "A macroscopic H+and Cl−ions pump via reconstitution of EcClC membrane proteins in lipidic cubic mesophases." Proceedings of the National Academy of Sciences 113, no. 27 (2016): 7491–96. http://dx.doi.org/10.1073/pnas.1603965113.

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Functional reconstitution of membrane proteins within lipid bilayers is crucial for understanding their biological function in living cells. While this strategy has been extensively used with liposomes, reconstitution of membrane proteins in lipidic cubic mesophases presents significant challenges related to the structural complexity of the lipid bilayer, organized on saddle-like minimal surfaces. Although reconstitution of membrane proteins in lipidic cubic mesophases plays a prominent role in membrane protein crystallization, nanotechnology, controlled drug delivery, and pathology of disease

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13

Basañez, Gorka, Juanita C. Sharpe, Jennifer Galanis, Teresa B. Brandt, J. Marie Hardwick, and Joshua Zimmerberg. "Bax-type Apoptotic Proteins Porate Pure Lipid Bilayers through a Mechanism Sensitive to Intrinsic Monolayer Curvature." Journal of Biological Chemistry 277, no. 51 (2002): 49360–65. http://dx.doi.org/10.1074/jbc.m206069200.

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During apoptosis, Bax-type proteins permeabilize the outer mitochondrial membrane to release intermembrane apoptogenic factors into the cytosol via a poorly understood mechanism. We have proposed that Bax and ΔN76Bcl-xL(the Bax-like cleavage fragment of Bcl-xL) function by forming pores that are at least partially composed of lipids (lipidic pore formation). Since the membrane monolayer must bend during lipidic pore formation, we here explore the effect of intrinsic membrane monolayer curvature on pore formation. Nonlamellar lipids with positive intrinsic curvature such as lysophospholipids pr

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14

ANGELOV, BORISLAV. "PROTEIN NANODOMAIN PATTERNS IN LIPIDIC BICONTINUOUS CUBIC PHASES." Modern Physics Letters B 16, no. 07 (2002): 225–30. http://dx.doi.org/10.1142/s0217984902003683.

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Ordered nanopatterns that match to the {6, 4} tiling of the diamond type infinite periodic minimal surface are generated. The construction of the unit cell, generally recognized as a Monkey Saddle, is done numerically using the exact Weierstrass–Enneper representation of minimal surfaces. The obtained patterns are a good model for the self-assembly nanodomain organizations of membrane proteins, compatible with 3- or 6-fold symmetries and formed upon reconstitution in bicontinuous cubic lipid phases.

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15

Sadchenko, A. O. "Correlations between molecular parameters of guest substances and their effect on model lipid membranes." Functional materials 23, no. 2 (2016): 230–35. http://dx.doi.org/10.15407/fm23.02.230.

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Polovinkin, Vitaly, Krishna Khakurel, Michal Babiak, et al. "Demonstration of electron diffraction from membrane protein crystals grown in a lipidic mesophase after lamella preparation by focused ion beam milling at cryogenic temperatures." Journal of Applied Crystallography 53, no. 6 (2020): 1416–24. http://dx.doi.org/10.1107/s1600576720013096.

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Electron crystallography of sub-micrometre-sized 3D protein crystals has emerged recently as a valuable field of structural biology. In meso crystallization methods, utilizing lipidic mesophases, particularly lipidic cubic phases (LCPs), can produce high-quality 3D crystals of membrane proteins (MPs). A major step towards realizing 3D electron crystallography of MP crystals, grown in meso, is to demonstrate electron diffraction from such crystals. The first task is to remove the viscous and sticky lipidic matrix that surrounds the crystals without damaging the crystals. Additionally, the cryst

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17

Vashchenko, O. V. "Comparative effects of stearic acid, calcium and magnesium stearates as dopants in model lipid membranes." Functional materials 25, no. 2 (2018): 300–307. http://dx.doi.org/10.15407/fm25.02.300.

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18

Kehlenbeck, Dominique-Maurice, Inokentijs Josts, Julius Nitsche, Sebastian Busch, V. Trevor Forsyth, and Henning Tidow. "Comparison of lipidic carrier systems for integral membrane proteins – MsbA as case study." Biological Chemistry 400, no. 11 (2019): 1509–18. http://dx.doi.org/10.1515/hsz-2019-0171.

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Abstract Membrane protein research suffers from the drawback that detergents, which are commonly used to solubilize integral membrane proteins (IMPs), often lead to protein instability and reduced activity. Recently, lipid nanodiscs (NDs) and saposin-lipoprotein particles (Salipro) have emerged as alternative carrier systems that keep membrane proteins in a native-like lipidic solution environment and are suitable for biophysical and structural studies. Here, we systematically compare nanodiscs and Salipros with respect to long-term stability as well as activity and stability of the incorporat

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19

Cort, Aysegul, Tomris Ozben, Anna Sansone, Sebastian Barata-Vallejo, Chryssostomos Chatgilialoglu, and Carla Ferreri. "Bleomycin-induced trans lipid formation in cell membranes and in liposome models." Organic & Biomolecular Chemistry 13, no. 4 (2015): 1100–1105. http://dx.doi.org/10.1039/c4ob01924e.

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Bleomycin–iron complexes cause lipidcis–transisomerisation through thiyl radical formation and reactivity with unsaturated phospholipids, revealing membranes as a relevant and novel site of drug effect.

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20

Lee, David B. N., Nora Jamgotchian, Suni G. Allen, Michael B. Abeles, and Harry J. Ward. "A lipid-protein hybrid model for tight junction." American Journal of Physiology-Renal Physiology 295, no. 6 (2008): F1601—F1612. http://dx.doi.org/10.1152/ajprenal.00097.2008.

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The epithelial tight junction (TJ) was first described ultrastructurally as a fusion of the outer lipid leaflets of the adjoining cell membrane bilayers (hemifusion). The discovery of an increasing number of integral TJ and TJ-associated proteins has eclipsed the original lipid-based model with the wide acceptance of a protein-centric model for the TJ. In this review, we stress the importance of lipids in TJ structure and function. A lipid-protein hybrid model accommodates a large body of information supporting the lipidic characteristics of the TJ, harmonizes with the accumulating evidence su

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21

Lee, JinKeun, and Barry R. Lentz. "Evolution of Lipidic Structures during Model Membrane Fusion and the Relation of This Process to Cell Membrane Fusion†." Biochemistry 36, no. 21 (1997): 6251–59. http://dx.doi.org/10.1021/bi970404c.

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Yaghmur, Anan, Barbara Sartori, and Michael Rappolt. "The role of calcium in membrane condensation and spontaneous curvature variations in model lipidic systems." Phys. Chem. Chem. Phys. 13, no. 8 (2011): 3115–25. http://dx.doi.org/10.1039/c0cp01036g.

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Pušenjak, Rudolf, and Maks Oblak. "Simulacija akcijskega potenciala v Hodgkin-Huxleyevem modelu." Anali PAZU 1, no. 2 (2022): 122–27. http://dx.doi.org/10.18690/analipazu.1.2.122-127.2011.

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Vzdražljive (ekscitabilne) celice se imenujejo celice, ki so sposobne proizvajati akcijske potenciale. Akcijski potenciali nastajajojo v nevronih in mišicah v obliki signalov. Signalni mehanizem povzroča možgansko aktivnost oziroma krčenje mišic. Lipidni plasti celične membrane se obnašata kot kondenzator, spremenljive prevodnosti membrane za posamezne ione pa so posledica ionskih kanalov, ki se lahko odpirajo ali zapirajo in s tem bolje ali slabše prevajajo. Na tej osnovi lahko celično membrano modeliramo kot električno vezje. V članku je predstavljena izpeljava enačb Hodgkin-Huxleyevega mode

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Borshchevskiy, Valentin, Rouslan Efremov, Ekaterina Moiseeva, Georg Büldt, and Valentin Gordeliy. "Overcoming merohedral twinning in crystals of bacteriorhodopsin grown in lipidic mesophase." Acta Crystallographica Section D Biological Crystallography 66, no. 1 (2009): 26–32. http://dx.doi.org/10.1107/s0907444909042838.

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Twinning is one of the most common crystal-growth defects in protein crystallography. There are neither efficient rational approaches for the growth of nontwinned protein crystals nor are there examples of systematic studies of the dependence of the twinning-ratio distribution on crystallization conditions. The description of the twinning phenomenon has been covered even less for membrane-protein crystals and is non-existent for crystals grown using lipidic phases (in meso). In the present work, possibilities for overcoming merohedral twinning are investigated for crystals of the membrane prot

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Renno, Giacomo, Francesca Cardano, Giorgio Volpi, Claudia Barolo, Guido Viscardi, and Andrea Fin. "Imidazo[1,5-a]pyridine-Based Fluorescent Probes: A Photophysical Investigation in Liposome Models." Molecules 27, no. 12 (2022): 3856. http://dx.doi.org/10.3390/molecules27123856.

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Imidazo[1,5-a]pyridine is a stable scaffold, widely used for the development of emissive compounds in many application fields (e.g., optoelectronics, coordination chemistry, sensors, chemical biology). Their compact shape along with remarkable photophysical properties make them suitable candidates as cell membrane probes. The study of the membrane dynamics, hydration, and fluidity is of importance to monitor the cellular health and to explore crucial biochemical pathways. In this context, five imidazo[1,5-a]pyridine-based fluorophores were synthesized according to a one-pot cyclization between

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de Souza Teixeira, Leonardo, Tatiana Vila Chagas, Antonio Alonso, et al. "Biomimetic Artificial Membrane Permeability Assay over Franz Cell Apparatus Using BCS Model Drugs." Pharmaceutics 12, no. 10 (2020): 988. http://dx.doi.org/10.3390/pharmaceutics12100988.

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A major parameter controlling the extent and rate of oral drug absorption is permeability through the lipid bilayer of intestinal epithelial cells. Here, a biomimetic artificial membrane permeability assay (Franz–PAMPA Pampa) was validated using a Franz cells apparatus. Both high and low permeability drugs (metoprolol and mannitol, respectively) were used as external standards. Biomimetic properties of Franz–PAMPA were also characterized by electron paramagnetic resonance spectroscopy (EPR). Moreover, the permeation profile for eight Biopharmaceutic Classification System (BCS) model drugs cite

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Zatloukalova, Martina, Ewa Nazaruk, and Renata Bilewicz. "Electrogenic transport of Na+/K+-ATPase incorporated in lipidic cubic phases as a model biomimetic membrane." Electrochimica Acta 310 (July 2019): 113–21. http://dx.doi.org/10.1016/j.electacta.2019.04.082.

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Vandoolaeghe, Pauline, Adrian R. Rennie, Richard A. Campbell, et al. "The Delivery of Lipidic Compounds to Model Membrane Interfaces by Non-lamellar Liquid Crystalline Nano-particles." Biophysical Journal 96, no. 3 (2009): 19a. http://dx.doi.org/10.1016/j.bpj.2008.12.1000.

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Nomura, Kaoru, Gilles Ferrat, Terumi Nakajima, Herve Darbon, Takashi Iwashita, and Gerardo Corzo. "S1h1-5 Interactions of two kinds of arthropods-derived antimicrobial peptides, pandinins and oxyopinins, with model lipid membranes(S1-h1 "Antimicrobial Peptides and Membrane Interactions",Symposia,Abstract,Meeting Program of EABS & BSJ 2006)." Seibutsu Butsuri 46, supplement2 (2006): S113. http://dx.doi.org/10.2142/biophys.46.s113_3.

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Morigaki, Kenichi. "S1e2-8 Micropatterned composite membranes of polymerized and fluid lipid bilayers as a versatile model cellular membrane(S1-e2: "New Biomembrane Model Systems, Giant Liposomes and Supported Planar Bilayers, for Probing Biomembrane Structure and Function, and Creation of De Novo Functional Membrane System",Symposia,Abstract,Meeting Program of EABS & BSJ 2006)." Seibutsu Butsuri 46, supplement2 (2006): S118. http://dx.doi.org/10.2142/biophys.46.s118_4.

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Sunami, Takeshi, Kazufumi Hosoda, Hiroaki Suzuki, Tomoaki Matsuura, and Tetsuya Yomo. "Cellular Compartment Model for Exploring the Effect of the Lipidic Membrane on the Kinetics of Encapsulated Biochemical Reactions." Langmuir 26, no. 11 (2010): 8544–51. http://dx.doi.org/10.1021/la904569m.

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Ito, Koreaki, Naomi Shimokawa-Chiba, and Shinobu Chiba. "Sec translocon has an insertase-like function in addition to polypeptide conduction through the channel." F1000Research 8 (December 20, 2019): 2126. http://dx.doi.org/10.12688/f1000research.21065.1.

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The Sec translocon provides a polypeptide-conducting channel, which is insulated from the hydrophobic lipidic environment of the membrane, for translocation of hydrophilic passenger polypeptides. Its lateral gate allows a downstream hydrophobic segment (stop-transfer sequence) to exit the channel laterally for integration into the lipid phase. We note that this channel model only partly accounts for the translocon function. The other essential role of translocon is to facilitate de novo insertion of the N-terminal topogenic segment of a substrate polypeptide into the membrane. Recent structura

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Vasco, Aldrin V., Martina Brode, Yanira Méndez, Oscar Valdés, Daniel G. Rivera, and Ludger A. Wessjohann. "Synthesis of Lactam-Bridged and Lipidated Cyclo-Peptides as Promising Anti-Phytopathogenic Agents." Molecules 25, no. 4 (2020): 811. http://dx.doi.org/10.3390/molecules25040811.

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Antimicrobial resistance to conventional antibiotics and the limited alternatives to combat plant-threatening pathogens are worldwide problems. Antibiotic lipopeptides exert remarkable membrane activity, which usually is not prone to fast resistance formation, and often show organism-type selectivity. Additional modes of action commonly complement the bioactivity profiles of such compounds. The present work describes a multicomponent-based methodology for the synthesis of cyclic polycationic lipopeptides with stabilized helical structures. The protocol comprises an on solid support Ugi-4-compo

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V.Kh., Gasimova. "Use of Polyene Macrolide Antibiotics In Combination With Dimethil Sulfoxide As Antiviral And Antifungal Agent At Plant Treatment." Journal of Life Sciences and Biomedicine 70, no. 2 (2022): 109–14. https://doi.org/10.5281/zenodo.7423977.

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Comparative physical and chemical characteristics of dimethyl sulfoxide (DMSO) and polyene antibiotics (PA) have been presented in this paper. The effect of a complex interaction of DMSO and PA with bilayer lipid membranes was examined and the results of experimental studies of physical and chemical characteristics of amphotericin B and levorin molecules and the interaction with the membranes were discussed. On the basis of PA molecules a theoretical model of creating effective membrane-active preparation against viral and fungal diseases of plants was developed.

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SILVA JUNIOR, IZAN M., MARIA CLÍCIA S. CASTRO, DILSON SILVA, and CÉLIA M. CORTEZ. "Relevance of Hydrodynamic Effects for the Calculation of Outer Surface Potential of Biological Membrane Using Electrophoretic Data." Anais da Academia Brasileira de Ciências 88, no. 2 (2016): 751–63. http://dx.doi.org/10.1590/0001-3765201620140530.

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ABSTRACT In this paper, we present the results of a study on the influence of hydrodynamic effects on the surface potentials of the erythrocyte membrane, comparing two different models formulated to simulate the electrophoretic movement of a biological cell: the classical Helmholtz-Smoluchowski model and a model presented by Hsu et al. (1996). This model considers hydrodynamic effects to describe the distribution of the fluid velocity. The electric potential equation was obtained from the non-linear Poisson-Boltzmann equation, considering the spatial distribution of electrical charges fixed in

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Trampari, Sofia, Caroline Neumann, Samuel J. Hjorth-Jensen, Azadeh Shahsavar, Esben M. Quistgaard, and Poul Nissen. "Insights into the mechanism of high lipid–detergent crystallization of membrane proteins." Journal of Applied Crystallography 54, no. 6 (2021): 1775–83. http://dx.doi.org/10.1107/s1600576721010669.

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Obtaining well diffracting crystals of membrane proteins is often challenging, but chances can be improved by crystallizing them in lipidic conditions that mimic their natural membrane environments. One approach is the high lipid–detergent (HiLiDe) method, which works by mixing the target protein with high concentrations of lipid and detergent prior to crystallization. Although this approach is convenient and flexible, understanding the effects of systematically varying lipid/detergent ratios and a characterization of the lipid phases that form during crystallization would be useful. Here, a H

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Bozzer, Sara, Michele Dal Bo, Giuseppe Toffoli, Paolo Macor, and Sara Capolla. "Nanoparticles-Based Oligonucleotides Delivery in Cancer: Role of Zebrafish as Animal Model." Pharmaceutics 13, no. 8 (2021): 1106. http://dx.doi.org/10.3390/pharmaceutics13081106.

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Oligonucleotide (ON) therapeutics are molecular target agents composed of chemically synthesized DNA or RNA molecules capable of inhibiting gene expression or protein function. How ON therapeutics can efficiently reach the inside of target cells remains a problem still to be solved in the majority of potential clinical applications. The chemical structure of ON compounds could affect their capability to pass through the plasma membrane. Other key factors are nuclease degradation in the extracellular space, renal clearance, reticulo-endothelial system, and at the target cell level, the endolyso

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Cornell, Bruce A. "S1e2-5 Immunosensors based on Tethered Lipid Membranes(S1-e2: "New Biomembrane Model Systems, Giant Liposomes and Supported Planar Bilayers, for Probing Biomembrane Structure and Function, and Creation of De Novo Functional Membrane System",Symposia,Abstract,Meeting Program of EABS & BSJ 2006)." Seibutsu Butsuri 46, supplement2 (2006): S118. http://dx.doi.org/10.2142/biophys.46.s118_1.

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Romano, Eugenia, Paolo Antonio Netti, and Enza Torino. "A High Throughput Approach Based on Dynamic High Pressure for the Encapsulation of Active Compounds in Exosomes for Precision Medicine." International Journal of Molecular Sciences 22, no. 18 (2021): 9896. http://dx.doi.org/10.3390/ijms22189896.

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In recent decades, endogenous nanocarrier-exosomes have received considerable scientific interest as drug delivery systems. The unique proteo-lipid architecture allows the crossing of various natural barriers and protects exosomes cargo from degradation in the bloodstream. However, the presence of this bilayer membrane as well as their endogenous content make loading of exogenous molecules challenging. In the present work, we will investigate how to promote the manipulation of vesicles curvature by a high-pressure microfluidic system as a ground-breaking method for exosomes encapsulation. Exos

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Pan, Dongqing, Ryo Oyama, Tomomi Sato, et al. "Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX." IUCrJ 9, no. 1 (2021): 134–45. http://dx.doi.org/10.1107/s2052252521011611.

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CmABCB1 is a Cyanidioschyzon merolae homolog of human ABCB1, a well known ATP-binding cassette (ABC) transporter responsible for multi-drug resistance in various cancers. Three-dimensional structures of ABCB1 homologs have revealed the snapshots of inward- and outward-facing states of the transporters in action. However, sufficient information to establish the sequential movements of the open–close cycles of the alternating-access model is still lacking. Serial femtosecond crystallography (SFX) using X-ray free-electron lasers has proven its worth in determining novel structures and recording

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V.Kh., Qasimova. "Solutions of environmental problems with the use of polyene macrolactone preparation in combination with dimethyl sulfoxide." Journal of Life Sciences and Biomedicine 73, no. 3 (2018): 53–58. https://doi.org/10.5281/zenodo.7409496.

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Biological activity of antibiotics was shown to increase sharply when polyene antibiotics (PA) were used in combination with dimethyl sulfoxide (DMSO). Comparative physico-chemical characteristics of DMSO and PO were presented. Effects of the interaction of DMSO and PA with the bilayer lipid membranes (BLM) were considered. Parameters of the biological activity of PA were determined using the BLM method. Amphotericin B and levorin appeared to be the most effective among the all studied PA. The dependence between BLM conductivity and concentrations of amphotericin B and levorin as well as conce

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Taniguchi, Emi, Katsuyuki Nishimura та Akira Naito. "1P346 Conformation and interaction of β-endorphin with a model membrane consisting of unsaturated lipid bilayers as studied by solid-state NMR(12. Membrane dynamics,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)". Seibutsu Butsuri 46, supplement2 (2006): S233. http://dx.doi.org/10.2142/biophys.46.s233_2.

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Nakane, Takanori, Shinya Hanashima, Mamoru Suzuki, et al. "Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent." Proceedings of the National Academy of Sciences 113, no. 46 (2016): 13039–44. http://dx.doi.org/10.1073/pnas.1602531113.

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The 3D structure determination of biological macromolecules by X-ray crystallography suffers from a phase problem: to perform Fourier transformation to calculate real space density maps, both intensities and phases of structure factors are necessary; however, measured diffraction patterns give only intensities. Although serial femtosecond crystallography (SFX) using X-ray free electron lasers (XFELs) has been steadily developed since 2009, experimental phasing still remains challenging. Here, using 7.0-keV (1.771 Å) X-ray pulses from the SPring-8 Angstrom Compact Free Electron Laser (SACLA), i

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Takagishi, Isao, Akira Yamagishi, Hiromitsu Nakazawa, Shingo Sakai, Shintaro Inoue, and Satoru Kato. "2P282 Study on the Packing Structure of the Stratum Corneum Lipid Model by Electron Diffraction(40. Membrane structure,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)." Seibutsu Butsuri 46, supplement2 (2006): S366. http://dx.doi.org/10.2142/biophys.46.s366_2.

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Losada-Barreiro, Sonia, Fátima Paiva-Martins, and Carlos Bravo-Díaz. "Partitioning of Antioxidants in Edible Oil–Water Binary Systems and in Oil-in-Water Emulsions." Antioxidants 12, no. 4 (2023): 828. http://dx.doi.org/10.3390/antiox12040828.

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In recent years, partitioning of antioxidants in oil–water two-phase systems has received great interest because of their potential in the downstream processing of biomolecules, their benefits in health, and because partition constant values between water and model organic solvents are closely related to important biological and pharmaceutical properties such as bioavailability, passive transport, membrane permeability, and metabolism. Partitioning is also of general interest in the oil industry. Edible oils such as olive oil contain a variety of bioactive components that, depending on their p

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Olena, Ruban, Zupanets Ihor, Kolisnyk Tetiana, et al. "Pharmacological and biopharmaceutical studies of paracetamol and N-acetyl-D-glucosamine combination as an analgetic drug." ScienceRise: Pharmaceutical Science, no. 1(35) (February 28, 2022): 28–36. https://doi.org/10.15587/2519-4852.2022.253474.

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<strong>The aim.</strong> Experimental selection of paracetamol and N-acetyl-D-glucosamine (NAG) ratio and combined dose and bioavailability study of the pharmaceutical composition and active pharmaceutical ingredient (API) in the model of cell biomembranes. <strong>Materials and methods.</strong> The following substances were used: paracetamol, Actimask Acetaminophen (gelatin-coated paracetamol), and NAG. For pharmacological studies were used laboratory rats, which received test objects intragastrically. The study was performed on the model of inflammatory hyperalgesia according to

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Abdali, Narges, Farhan Younas, Samaneh Mafakheri, et al. "Identification and characterization of smallest pore-forming protein in the cell wall of pathogenic Corynebacterium urealyticum DSM 7109." BMC Biochemistry 19, no. 1 (2018): 3. https://doi.org/10.1186/s12858-018-0093-9.

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<strong>Background: </strong> <i>Corynebacterium urealyticum</i>, a pathogenic, multidrug resistant member of the mycolata, is known as causative agent of urinary tract infections although it is a bacterium of the skin flora. This pathogenic bacterium shares with the mycolata the property of having an unusual cell envelope composition and architecture, typical for the genus <i>Corynebacterium</i>. The cell wall of members of the mycolata contains channel-forming proteins for the uptake of solutes.<strong>Results: </strong>In this study, we provide novel information on the identification and ch

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Kushnerova, Natalya F., Yury A. Rakhmanin, Tatiana V. Momot, et al. "Assessment of changes in blood plasma biochemical indices at hypercholesterol diet with a high fat load." Hygiene and sanitation 100, no. 6 (2021): 617–22. http://dx.doi.org/10.47470/0016-9900-2021-100-6-617-622.

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Introduction. It was studied the lipid composition of the blood plasma of rats under the impact of a hyper cholesterol diet with a high fat load. It was carried out the prevention of disturbances in blood plasma biochemical parameters with a lipid complex from the tunic of the marine hydrobiont Halocynthia aurantium. Materials and methods. The experiment was carried outwith outbred male rats weighing 200 ± 3 g.The experimental model of a hyper cholesterol diet with a high fat load with the development of dyslipidemia was set up by feeding the animals with ahigh fat diet consisting of 2% choles

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Sagrafena, Irene, Maxim Morin, Georgios Paraskevopoulos, et al. "Structure and function of skin barrier lipids: Effects of hydration and natural moisturizers in vitro." Biophysical Journal 123, no. 22 (2024): 3951–63. https://doi.org/10.1016/j.bpj.2024.10.006.

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Lipid membranes play a crucial role in regulating the body's water balance by adjusting their properties in response to hydration. The intercellular lipid matrix of the stratum corneum (SC), the outermost skin layer, serves as the body's primary defense against environmental factors. Osmolytes, including urocanic acid (UCA) and glycerol, are key components of the natural moisturizing factor that help the SC resist osmotic stress from dry environments. This study examines the effects of UCA and glycerol (each at 5 mol%) on isolated human SC lipids. For this, different techniques were employed,

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Kjølbye, Lisbeth R., Gilberto P. Pereira, Alessio Bartocci, et al. "Towards design of drugs and delivery systems with the Martini coarse-grained model." QRB Discovery 3 (October 12, 2022): e19. https://doi.org/10.1017/qrd.2022.16.

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Coarse-grained (CG) modelling with the Martini force field has come of age. By combining a variety of bead types and sizes with a new mapping approach, the newest version of the model is able to accurately simulate large biomolecular complexes at millisecond timescales. In this perspective, we discuss possible applications of the Martini 3 model in drug discovery and development pipelines and highlight areas for future development. Owing to its high simulation efficiency and extended chemical space, Martini 3 has great potential in the area of drug design and delivery. However, several aspects

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