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Rozprawy doktorskie na temat „Liver Copper”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

SAKAMOTO, NOBUO, HISAO HAYASHI, TOMOYUKI HIGUCHI, AKIRA YAGI, and NAOKI HISHIDA. "Cuproproteins of Hepatocyte Lysosomes in Normal and Fatty Liver." Nagoya University School of Medicine, 1993. http://hdl.handle.net/2237/17538.

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Davis, William. "Synthesis and secretion of caeruloplasmin in normal and copper toxic liver." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283963.

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Leighton, Margaret Janet. "The accumulation and subcellular localization of copper in the liver of foetal deer." Thesis, Royal Veterinary College (University of London), 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519519.

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Hassel, Craig Alan. "LIPOPROTEIN RECEPTORS IN COPPER-DEFICIENT RATS: IN VITRO BINDING OF HIGH DENSITY LIPOPROTEIN SUBFRACTIONS TO LIVER MEMBRANES." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183955.

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Three studies were conducted to determine whether the elevated plasma and HDL cholesterol levels observed in copper-deficient rats could be explained by the interaction of ¹²⁵I-HDL subfractions with liver membrane preparations in vitro. Rats from all studies were randomly divided into two dietary treatments, copper-deficient and adequate (0.7 mg and 8.0 mg Cu/kg diet, respectively). Deionized water and diet were provided ad libitum. After eight weeks, rats were exsanguinated, membranes prepared from livers, and plasma high density lipoproteins (HDL) isolated by ultracentrifugation and agarose

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5

Zhang, Jin 1960. "The influence of copper deficiency on the binding and uptake of high-density lipoprotein by rat hepatic parenchymal cells." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276935.

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This study was designed to examine the influence of Cu deficiency on the binding, uptake, and degradation of apolipoprotein E-free high density lipoproteins (apo E-free HDL) in cultured rat hepatic parenchymal cells. The binding of apo E-free HDL during time course studies was slightly but significantly increased in cells derived from Cu-deficient rats. In saturation studies, the amount of surface-bound apo E-free HDL appeared to be saturable, although no difference was observed between Cu-deficient and adequate animals. The amount of total and specific cell-associated uptake of apo E-free HDL

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Minervino, Antonio Humberto Hamad. "Estudo comparativo da susceptibilidade de bovinos e bufalinos à intoxicação cúprica acumulativa." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-25042007-100336/.

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O presente trabalho objetivou avaliar comparativamente a susceptibilidade dos bufalinos e bovinos à intoxicação cúprica acumulativa, por meio do fornecimento de quantidades crescentes de cobre, analisando variáveis clínicas, sangüíneas e os teores de cobre hepático. Com tal objetivo, foram utilizados 20 ruminantes, 10 bovinos (mestiços) e 10 búfalos (raça Murrah) jovens, aleatoriamente distribuídos em seis animais de cada espécie nos grupos que receberam cobre (BOV Cu e BUF Cu) e quatro animais nos grupos controle (BOV e BUF). Diariamente, os grupos BOV Cu e BUF Cu receberam por meio de fistu

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7

黃業發 and Ip-fat Wong. "Effects of D-penicillamine on the alterations in copper and zinc disposition in liver tissues following endotoxin treatment ingalactosamine-sensitized mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31969859.

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Wong, Ip-fat. "Effects of D-penicillamine on the alterations in copper and zinc disposition in liver tissues following endotoxin treatment in galactosamine-sensitized mice." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22032460.

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Al-Othman, Abdullah Abdulrahman. "Influence of copper deficiency on liver morphology, aortic integrity, plasma lipoprotein and hepatic lipid profiles, and hepatic fatty acid synthesis in vivo." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185745.

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Three studies were designed to investigate the influence of dietary copper (Cu) on liver morphology, aortic integrity, lipid composition of lipoproteins, fatty acid profile of hepatic lipids, as well as in vivo hepatic fatty acid synthesis. Animals were randomly assigned to two dietary Cu treatments (deficient and adequate). Reductions in body weight, liver Cu content, and hematocrit, as well as elevations in liver weight and plasma volume were observed in animals fed Cu-deficient diet. Electron micrographs suggest that the Cu-deficient liver parenchymal cells contain a higher number of mitoch

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Lentz, Daniela. "Deficiência de cobre como causa de enfermidade sazonal em bovinos no Estado de Santa Catarina." Universidade do Estado de Santa Catarina, 2012. http://tede.udesc.br/handle/handle/801.

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Made available in DSpace on 2016-12-08T16:24:04Z (GMT). No. of bitstreams: 1 PGCA12MA038.pdf: 2912659 bytes, checksum: a707fa201b75de04c816893aa22d474d (MD5) Previous issue date: 2012-06-15<br>It has been described the epidemiological, clinical signs and lesions of a disease of cattle characterized by seasonal occurrence of outbreaks of diarrhea, chronic fever, responsive to treatment with copper sulfate. The disease occurs on properties with steeply sloping topography of the different regions of the state of Santa Catarina, with greater frequency in the west Highlands and Serra, in the mont

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SISTI, CRISTINA. "Aplicacao de diferentes metodologias na preparacao de matrizes organicas para a determinacao voltametrica de elementos traco." reponame:Repositório Institucional do IPEN, 2001. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10891.

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Made available in DSpace on 2014-10-09T12:45:12Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:01:26Z (GMT). No. of bitstreams: 1 07287.pdf: 2056507 bytes, checksum: 770280526de75f4fc2cf87a5aa34f1e9 (MD5)<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

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MARQUES, Allan Vieira dos Santos. "Teores de cobre e seus principais antagonistas em fígado e sangue de ovinos e caprinos criados no estado de Pernambuco." Universidade Federal Rural de Pernambuco, 2010. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5116.

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Submitted by (edna.saturno@ufrpe.br) on 2016-07-29T11:50:01Z No. of bitstreams: 1 Allan Vieira dos Santos Marques.pdf: 717930 bytes, checksum: aa978139a85c2cfa9f5a7df5d8379ad4 (MD5)<br>Made available in DSpace on 2016-07-29T11:50:01Z (GMT). No. of bitstreams: 1 Allan Vieira dos Santos Marques.pdf: 717930 bytes, checksum: aa978139a85c2cfa9f5a7df5d8379ad4 (MD5) Previous issue date: 2010-02-26<br>Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq<br>The aim of this research was to know serum and liver concentrations of Cu, Mo, Fe and Zn in sheep and goats slaughte

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13

Cadiou, Jean-Loup. "Etude des mécanismes de fractionnement isotopique du cuivre par les cellules eucaryotes. Vers le développement d'un nouveau biomarqueur non-invasif de l'apparition d'une chimio-résistance au cisplatine des cellules cancéreuses." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEN072/document.

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Le développement de cancer entraîne une dérégulation du métabolisme du cuivre (Cu) qui a notamment été étudiée par analyse de la composition isotopique naturelle du Cu. Les cellules tumorales hépatiques sont enrichies en isotopes lourds du Cu par rapport aux cellules péri-tumorales. Le but de cette thèse est d'identifier les mécanismes responsables de cette différence, en utilisant la levure Saccharomyces cerevisiae dont les mécanismes de réduction et d'import du Cu sont proches de ceux de l'Homme. En mutant les gènes codants pour les importateurs ou les réductases du Cu, j’ai montré que son i

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14

Valenzuela, Pérez Leonardo F. "Coppered Lives: The Chilean sacrifice zone of Quintero Bay." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15914.

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In September 1964, when Las Ventanas copper smelter was opened in Quintero Bay it was welcomed as a key piece in the Chilean development strategy. Just over fifty years later, Quintero Bay hosts the largest industrial complex in Chile and has become the site of a chronic environmental disaster, with recurrent pollution crises and industrial accidents that pose massive risks to its human and nonhuman residents. Through historical and ethnographic analysis, involving the use of archival documents, government proceedings, media publications, interviews and participant observation, this thesis inv

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15

Jullien, Anne-Solène. "Synthèse et étude de nouveaux chélateurs pour la détoxification d'ions métalliques d¹º dans l'organisme." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV028.

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Ce travail de thèse a consisté à synthétiser de nouveaux chélateurs pour la complexation des ions métalliques d10 toxiques en milieu biologique, comme le cuivre (I), lorsqu'il est présent en excès dans les cellules, et le mercure (II), délétère à l'état de traces. En particulier, des tripodes à trois soufres, inspirés de tripodes fonctionnalisés par trois dérivés cystéine, développés antérieurement au laboratoire, ont été élaborés et leur propriétés de complexation avec le cuivre (I) ont été examinées. Comme les tripodes cystéines, les nouveaux tripodes fonctionnalisés par d'autres dérivés sou

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16

Duval, Hugo. "Investigation on blanching on cryogenic engines combustion chamber inner liner." Thesis, Châtenay-Malabry, Ecole centrale de Paris, 2014. http://www.theses.fr/2014ECAP0059.

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Les conditions thermodynamiques et cinétiques dans les moteurs cryogéniques sont sévères, en particulier pour la mince paroi interne de la chambre de combustion. Bien que peu résistant mécaniquement, un alliage de cuivre est utilisé pour maximiser les transferts thermiques à travers cette paroi et ainsi améliorer l’efficacité du moteur. Cependant, les fluctuations de concentration et de pression des propergols (tels que l’oxygène ou l’hydrogène liquide) à la surface de la paroi favorisent l’endommagement de l’alliage, en particulier si la paroi n’est pas en permanence couverte d’une pellicule

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Silva, Danilo Pacheco e. "Influência da contaminação por cloreto de cobre na resistência ao cisalhamento de solos utilizados em liners." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/18/18132/tde-28042006-092801/.

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Avaliou-se, experimentalmente, o efeito da contaminação, por uma solução de cloreto de cobre, na resistência ao cisalhamento de solos a serem utilizados na construção de liners. Foi escolhido o cloreto de cobre como contaminante pelo fato de os íons cobre serem os mais comuns nos aterros sanitários industriais. Apresentam-se resultados de ensaios de percolação em colunas e ensaios triaxiais convencionais do tipo CU para solos provenientes das formações Serra Geral (argilosos), Botucatu (arenosos) e uma mistura dos mesmos na proporção de 20% de solo Serra Geral e 80% de solo Botucatu. A mistura

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18

Butterworth, Andrew D. "The utilisation of layered hydroxysalts in the separation, immobilisation and long term storage of long-lived radio-anions of nuclear power legacy waste origin." Thesis, Loughborough University, 2013. https://dspace.lboro.ac.uk/2134/13639.

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Long lived radioactive species such as ¹²⁹I⁻ and ⁹⁹TcO₄⁻ are formed as by-products of nuclear fission. These species have extremely long half-lives (1.5 million and 211,000 years respectively), are biologically assimilating and due to their anionic nature, can move freely within a geosphere. Historical disposal methods for active species are no longer considered acceptable to the general public and other ways in which to treat the waste are being explored. One remove and concentrate method to remove radioactive species from the biosphere is using alkaline-resistant materials which trap active

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19

Fonseca, Antonio Eduardo. "Controle da mancha preta dos citros via fungicida cúprico e validação da produção de frutos cítricos em área não livre da doença : estudo de caso /." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152441.

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Submitted by ANTONIO EDUARDO FONSECA null (eduardofonseca.tva@gmail.com) on 2018-01-08T18:25:55Z No. of bitstreams: 1 Tese Final 0801.pdf: 1442032 bytes, checksum: 89542ace4e746a273c5a088d6a6ec38c (MD5)<br>Rejected by Alexandra Maria Donadon Lusser Segali null (alexmar@fcav.unesp.br), reason: Solicitamos que realize as correções na submissão seguindo as orientações abaixo: Estão faltando a ficha catalográfica e o certificado de aprovação. Não há necessidade da informação da lombada (lateral da tese), no arquivo para a submissão. Agradecemos a compreensão. on 2018-01-09T09:24:23Z (GM

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20

Moreno, Ruben Gregorio Moreno. "Estudos de lesão ao DNA promovida pela autoxidação de S(IV) na presença de complexos de Cu(III)/tetraglicina. Efeito sinérgico de Ni(II), Co(II) e Mn(II)." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/46/46133/tde-04062007-032229/.

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O presente trabalho apresenta estudos de lesão em biomoléculas (DNA e 2\'-deoxiguanosina) induzida por Cu(III)/tetraglicina (Cu(III)/G4), radicais de óxidos de enxofre (SO3·-, SO4·-, SO5·-), HO· e HSO5-, espécies estas geradas durante a autoxidação de S(IV) na presença de Cu(II)/G4 ou Cu(II) (ausência de tetraglicina) e traços de um segundo íon metálico (Ni(II), Co(II) ou Mn(II)). A formação dos radicais SO3·- e HO· foi detectada pela técnica de ressonância paramagnética eletrônica (EPR). As técnicas de espectrofotometria e dicroísmo circular foram emp

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21

Landry, Annie. "Le rôle et la symbolique de la narratrice au sein du traité Le Tonnerre, Intellect Parfait." Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24233/24233.pdf.

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Chen, Guo Long, and 陳國隆. "Effects of dietary levels of copper and/orarsenic on performance, liver function, and their residue in liver, egg and excreta of laying hen." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/40249420291035955800.

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Capps, Kaylen McKenzie. "Copper supplementation and antimicrobial resistance in swine and Salmonella enterica in liver abscesses of cattle." Thesis, 2018. http://hdl.handle.net/2097/39287.

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Master of Science<br>Department of Diagnostic Medicine/Pathobiology<br>Raghavendra Amachawadi<br>T.G. Nagaraja<br>Copper is an essential micronutrient that is supplemented in swine diets as a growth promoter. Previous studies suggest a link between copper supplementation and co-selection of antimicrobial resistance (AMR) in Enterococcus, but the data are inconsistent. Therefore, the objective of this study was to assess the impact of copper supplementation, alone or with chlortetracycline (CTC), on prevalence and concentration of copper resistance gene, tcrB, prevalence of tetracycline [tet(M)

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24

Tsai, Wenpin, and 蔡文彬. "Selective Oxidative Modification and Affinity Cleavage of Pigeon Liver Malic Enzyme by the Copper-Ascorbate System." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/94521060120713527807.

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碩士<br>國防醫學院<br>生物化學研究所<br>82<br>Pigeon liver malic enzyme was rapidly inactivated by micromola concentration of sulfate in the presence of ascorbate at neutral pH. The inactivated enzyme was subsequently cleaved at the peptide bond between Asp258 and Ile259 [Wei, C. H., Chou, W. Y., Huang, S. M., Lin, C. C., and Chang, G. G. (1994) Biochemistry, in press] In this study, we found that at neutral pH, copper nitrate was more active in the oxidative modification of malic enzyme and the enzyme w

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Canosa, Diaz Beatriz. "Effects of copper in plasma, gills, liver and muscle of seabream (Sparus aurata, Linnaeus 1758) juveniles." Master's thesis, 2006. http://hdl.handle.net/10400.1/580.

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Dissertação de Mestrado, Aquacultura e Pescas, Faculdade de Ciências do Mar e do Ambiente, Universidade do Algarve, 2006<br>Em aquacultura, uma das principais restrições à produção é a ocorrência de doenças em peixes. O sulfato de cobre é extensamente utilizado como tratamento contra numerosos parasitas. Contudo, este composto é tóxico e fatal a altas concentrações. Ainda que os efeitos toxicológicos do cobre em peixes estejam amplamente documentados, existe uma elevada variabilidade de resultados apresentados. No presente estudo, 121 juvenis de dourada (Sparus aurata) de 130.97 0.91 g (

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LIN, RUI-FEN, and 林瑞芬. "Preparation of isolated eel liver cell suspension and its application on examination for toxicity of copper and zinc." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/33828262094096192045.

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Banerjee, Nivedita. "Systematic Approach to Compare the Inflammatory Response of Liver Cell Culture Systems Exposed to Silver, Copper, and Nickel Nanoparticles." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8414.

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Although nano-sized metal colloids are used in industrial and medicinal applications, little is known about the potential liver toxicity of these materials after occupational or intentional exposures. To begin to resolve some outstanding hepatotoxicity concerns, the inflammatory response of hepatocytes after exposure to metal colloids was assessed. Four ~30-nm-sized metal colloids, including silver (nano-Ag), copper (nano-Cu) and nickel (nano-Ni) were examined in an effort to understand the induced cytokine expression in a murine liver cell line (AML12). Here we also utilized another system, c

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Coelho, Teresa Sofia Lopes. "Avaliação de risco de teores de zinco e cobre em fígado de leitão." Master's thesis, 2018. http://hdl.handle.net/10316/84463.

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Dissertação de Mestrado em Segurança Alimentar apresentada à Faculdade de Farmácia<br>O presente trabalho experimental tem como objetivo a avaliação de risco apósdeterminação de teores de zinco, cobre, cádmio e selénio nos fígados de leitões da zona daBairrada. A dieta dos leitões vai influenciar a acumulação destes metais, sendo que osmesmos são adicionados às rações.A determinação dos teores foi realizada com espectrofotometria de absorçãoatómica com chama.O número de amostras de fígado avaliadas foi de 48, provenientes de diferentesexplorações pecuárias, nomeadamente interpostos, pequenas e

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Duraippandi, P. "Targeting Cancer Cells And Live Cell Imaging Using Bis(thiosemicarbazone) Complexes Of Copper And Zinc." Thesis, 2012. https://etd.iisc.ac.in/handle/2005/2504.

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Transition metal bis(thiosemicarbazone) complexes have been of great interest in the last five decades. One of the most striking features of these complexes is that they possess a wide range of biological properties including antimalarial, antibacterial and anticancer activity. Zinc and copper bis(thiosemicarbazone) complexes have recently attracted attention due to their intracellular fluorescence and anticancer activity, respectively. The present work “Targeting Cancer Cells and Live Cell Imaging Using Bis(thiosemicarbazone) Complexes of Copper and Zinc” is an effort to target cancer cells u

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Duraippandi, P. "Targeting Cancer Cells And Live Cell Imaging Using Bis(thiosemicarbazone) Complexes Of Copper And Zinc." Thesis, 2012. http://hdl.handle.net/2005/2504.

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Transition metal bis(thiosemicarbazone) complexes have been of great interest in the last five decades. One of the most striking features of these complexes is that they possess a wide range of biological properties including antimalarial, antibacterial and anticancer activity. Zinc and copper bis(thiosemicarbazone) complexes have recently attracted attention due to their intracellular fluorescence and anticancer activity, respectively. The present work “Targeting Cancer Cells and Live Cell Imaging Using Bis(thiosemicarbazone) Complexes of Copper and Zinc” is an effort to target cancer cells u

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Ndhlala, Blessing. "Modelling, simulation and optimisation of a crushing plant." Diss., 2017. http://hdl.handle.net/10500/22954.

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African copper PLC’s flagship is the copper producing Mowana mine located 129 km from Francistown in the North-Eastern part of the Republic of Botswana. The processing operation at Mowana is a standard flotation plant designed to produce copper concentrates from oxide, supergene, and sulphide ores. The expected average output of 16.2 tons per hour of copper concentrates has never been attained since plant commissioning. The major bottleneck has been established to be located around the crushing circuit of the Mowana production chain. The major hypotheses of this research are that performance

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