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Artykuły w czasopismach na temat „LNCaP cell line”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Yanish, Yu V., M. P. Prylutskyi, I. O. Sumnikova, et al. "THE INFLUENCE OF SPERMINE AND CHLORHEXIDINE ON THE SURVIVAL, ELECTROKINETIC AND CYTOMORPHOLOGICAL CHARACTERISTICS OF HUMAN PROSTATE CANCER CELLS." Oncology 25, no. 3 (2023): 186–93. http://dx.doi.org/10.15407/oncology.2023.03.186.

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Summary. Aim: to study the effects of spermine and the spermine oxidase inhibitor chlorhexidine, applied alone or in combination, on the viability, electrokinetic and structural-functional characteristics of human prostate cancer cells in vitro. Object and methods: Studies were conducted on cell cultures: differentiated androgen-dependent LNCaP cell line and low-differentiated androgen-independent DU-145 cell line. Cell survival was determined by the method of exclusion of the vital dye trypan blue by living cells. The electrokinetic parameters of the cells (ζ-potential and total surface charg

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2

Kim, Sang Soo, Hee Joo Cho, Jung Yoon Kang, Hee Kyu Kang, and Tag Keun Yoo. "Inhibition of Androgen Receptor Expression with Small Interfering RNA Enhances Cancer Cell Apoptosis by Suppressing Survival Factors in Androgen Insensitive, Late Stage LNCaP Cells." Scientific World Journal 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/519397.

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Introduction.The aim was to evaluate the changes of androgen receptor (AR) expression quantitatively and to identify influence of AR on cancer related survival markers in LNCap cell line.Materials and Methods. We compared expressions of AR, heat shock protein 27 (HSP27), clusterin (CLU), glucose-related protein 78 (GRP78), and cellular FLICE-like inhibitory protein (c-FLIP) and their genes between es-LNCaP (less than 33 times subcultured, L-33), ls-LNCaP (over 81 times subcultured, H-81), and si-LNCaP (AR siRNA transfected ls-LNCaP) by Western blotting and RT-PCR.Results. The expressions of AR

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3

Lima, Thiago S., Diego Iglesias-Gato, Luciano D. O. Souza, et al. "Molecular Profiling of Docetaxel-Resistant Prostate Cancer Cells Identifies Multiple Mechanisms of Therapeutic Resistance." Cancers 13, no. 6 (2021): 1290. http://dx.doi.org/10.3390/cancers13061290.

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Docetaxel—a taxane-based chemotherapeutic agent—was the first treatment to demonstrate significant improvements in overall survival in men with metastatic castration-resistant prostate cancer (mCRPC). However, the response to docetaxel is generally short-lived, and relapse eventually occurs due to the development of resistance. To explore the mechanisms of acquired docetaxel resistance in prostate cancer (PCa) and set these in the context of androgen deprivation therapy, we established docetaxel-resistant PCa cell lines, derived from the androgen-dependent LNCaP cell line, and from the LNCaP l

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4

Guillemette, Chantal, and Alain Bélanger. "Glucuronosyltransferase activity in human cancer cell line LNCaP." Molecular and Cellular Endocrinology 107, no. 2 (1995): 131–39. http://dx.doi.org/10.1016/0303-7207(94)03434-u.

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5

Ruokonen, Minna, Jing-Dong Shan, Pirjo Hedberg, Lila Patrikainen, and Pirkko Vihko. "Transfecting Well-Differentiated Prostatic Cancer Cell Line LNCaP." Biochemical and Biophysical Research Communications 218, no. 3 (1996): 794–96. http://dx.doi.org/10.1006/bbrc.1996.0141.

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6

Seki, Taiga, Yui Shimizu, Kyota Ishii, Yuzuki Takahama, Kazunori Kato, and Tomohiro Yano. "NK Cells Can Preferentially Target Prostate Cancer Stem-like Cells via the TRAIL/DR5 Signaling Pathway." Biomolecules 11, no. 11 (2021): 1702. http://dx.doi.org/10.3390/biom11111702.

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Background: The occurrence of androgen-dependent prostate cancer mainly depends on prostate cancer stem cells. To reduce the risk of androgen-dependent prostate cancer, the direct elimination of prostate cancer stem cells is important, but an elimination strategy has not yet been established. A previous study showed that natural killer (NK) cells can preferentially target cancer stem cells in several solid tumors except prostate cancer. In this context, this study was undertaken to investigate if NK cells can selectively attack androgen-dependent prostate cancer stem cells. Methods: Prostate c

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7

Yanish, Yu V., M. P. Prylutskyi, O. K. Voronina, and S. P. Zaletok. "THE INFLUENCE OF SPERMINE AND AMINOGUANIDINE ON THE MORPHOFUNCTIONAL CHARACTERISTICS OF HUMAN PROSTATE CANCER CELL LINE LNCaP." Oncology 25, no. 1 (2023): 24–31. http://dx.doi.org/10.15407/oncology.2023.01.024.

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Summary. Aim: to investigate the inhibitory effect of spermine (Spn) and the modifying effect of aminoguanidine (AG) on the structural and functional characteristics of human prostate cancer cells of the LNCaP line, depending on the mode of their use. Object and methods: studies were conducted in vitro on human prostate cancer (PC) cells of the hormone-dependent LNCaP line. Cell survival was determined by the trypan blue exclusion. The concentration of Spn used in the study was 1.5 and 5.0 mM, and AG in combination with Spn 1.5 mM. Changes in the morphology of LNCaP cells were evaluated under

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8

Kang, Minyong, Chang Wook Jeong, Kyoung-Hwa Lee, Ja Hyeon Ku, Hyeon Hoe Kim, and Cheol Kwak. "Histone demethylase KDM7a to control androgen receptor activity in hormone-sensitive prostate cancer." Journal of Clinical Oncology 35, no. 6_suppl (2017): 262. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.262.

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262 Background: Prostate cancer can be controlled by androgen-hormone treatment until the cancer becomes refractory. It is believed that hormone sensitivity is largely dependent on androgen receptor (AR) activity. Here, we investigated the molecular mechanism whereby androgen receptor activity is regulated by histone demethylase KDM7a, which demethylates histone H3K9 and H3K27. Methods: The LNCaP, PC3, and DU145 cell lines were cultured at 37 °C in 5% CO2 in Minimum Essential Medium alpha, which was supplemented with 10% fetal bovine serum. We engineered AR-positive LNCaP cells to stably expre

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9

Mohtashami, Leila, Narjes Ghows, Zahra Tayarani-Najaran, and Mehrdad Iranshahi. "Galbanic Acid-Coated Fe3O4 Magnetic Nanoparticles with Enhanced Cytotoxicity to Prostate Cancer Cells." Planta Medica 85, no. 02 (2018): 169–78. http://dx.doi.org/10.1055/a-0721-1886.

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AbstractGalbanic acid is a natural sesquiterpene coumarin compound with different biological activities, particularly cytotoxicity against LNCaP (an androgen-dependent prostate cancer cell line). Galbanic acid induces apoptosis in LNCaP via down-regulation of androgen receptor. However, the poor water-solubility of galbanic acid limits further in vitro and in vivo studies. In this study we present the synthesis of galbanic acid-coated Fe3O4 magnetic nanoparticles and their cytotoxicity evaluation on three prostate cancer cell lines, including PC3 (an androgen-independent cell line), LNCaP, and

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10

Abate-Shen, Cory, and Francisca Nunes de Almeida. "Establishment of the LNCaP Cell Line – The Dawn of an Era for Prostate Cancer Research." Cancer Research 82, no. 9 (2022): 1689–91. http://dx.doi.org/10.1158/0008-5472.can-22-1065.

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Abstract Among the relatively few established human prostate cancer cell lines, LNCaP cells are unique in their ability to model key stages of prostate cancer progression. Analyses of LNCaP cells and their derivatives have been invaluable for elucidating important translational aspects of prostate tumorigenesis, metastasis, and drug response, particularly in the context of androgen receptor signaling. Here, we present major highlights from a wealth of literature that has exploited LNCaP cells and their derivatives to inform on prostate cancer progression and androgen response for improving the

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11

Veldscholte, Jos, Cor A. Berrevoets, and Eppo Mulder. "Studies on the human prostatic cancer cell line LNCaP." Journal of Steroid Biochemistry and Molecular Biology 49, no. 4-6 (1994): 341–46. http://dx.doi.org/10.1016/0960-0760(94)90277-1.

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12

Inoue, Takahiro, Toru Yoshida, Yosuke Shimizu та ін. "Requirement of Androgen-Dependent Activation of Protein Kinase Cζ for Androgen-Dependent Cell Proliferation in LNCaP Cells and Its Roles in Transition to Androgen-Independent Cells". Molecular Endocrinology 20, № 12 (2006): 3053–69. http://dx.doi.org/10.1210/me.2006-0033.

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Abstract A cell line that we designed, AILNCaP, proliferated in androgen-depleted medium after emerging from long-term androgen-depleted cultures of an androgen-sensitive prostate cancer cell line, LNCaP. Using this cell line as a model of progression to androgen independence, we demonstrated that the activity of the mammalian target of rapamycin/p70 S6 kinase transduction pathway is down-regulated after androgen depletion in LNCaP, whereas its activation is related to transition of this cell line to androgen-independent proliferation. Kinase activity of protein kinase Cζ is regulated by andro

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13

Zuhrotun, Ade, Rizky Abdullah, Meiliana Thamrin, and Resti Febriliza. "Antitumor Activity of Soursop (Annona muricata L.) Leaves On Prostate Cancer Cell Line." Acta Pharmaceutica Indonesia 38, no. 2 (2013): 43–47. http://dx.doi.org/10.5614/api.v38i2.5208.

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Soursop (Annona muricata L.) leaves were used as a traditional drug for many diseases such as cancer. Statistical data from one cancer hospital in Jakarta in the period of 2005 and 2007 showed that prostate cancer has become one of ten common cancer cases in ambulatory patients. This research was conducted to investigate the potency of an herbal drug for prostate cancer. The soursop leaves were extracted by maceration and fractionated by liquid-liquid extraction. The activity of all samples was then tested by Brine Shrimp Lethality Test (BSLT) and MTT assay using prostate cell line, LNCaP. The

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14

Sluka, P., G. Whitty, and I. D. Davis. "Stimulation of prostate cancer cell proliferation by bone-derived factors." Journal of Clinical Oncology 29, no. 7_suppl (2011): 32. http://dx.doi.org/10.1200/jco.2011.29.7_suppl.32.

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32 Background: Interactions between cancer cells and their microenvironment affect the establishment and metastasis of cancer. The most common site of prostate cancer (PC) metastasis is bone. This study examined the effects of selected factors known to be produced by bone stroma (EGF, aFGF, HGF, β-NGF, TGF-β, and TNFα) on the proliferation of PC cells. The effect of cell culture medium (CM) conditioned by osteoblasts (OBCM) was also examined. Methods: The PC-derived cell lines PC3, LNCaP, and DU145 were used. Expression of receptors for the above-mentioned cytokines was assessed using real-tim

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15

Ishii, Kenichiro, Kazuhiro Iguchi, Chise Matsuda, Yoshifumi Hirokawa, Yoshiki Sugimura, and Masatoshi Watanabe. "Application of Original Prostate Cancer Progression Model Interacting with Fibroblasts in Preclinical Research." Journal of Clinical Medicine 13, no. 24 (2024): 7837. https://doi.org/10.3390/jcm13247837.

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Prostate cancer (PCa) is a heterogeneous disease that exhibits androgen sensitivity and responsiveness to androgen deprivation therapy (ADT). However, ADT induces only temporary remission, and the majority of PCa cases eventually progress to castration-resistant PCa (CRPC). During the development and progression of CRPC, androgen sensitivity and androgen receptor (AR) dependency in PCa cells are often deceased or lost due to ADT or spontaneously arising AR variants even before starting ADT. To prevent CRPC, a clinical PCa model derived from an AR-positive cancer cell line with weak or no andro

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Ishii, Kenichiro, Takeshi Sasaki, Kazuhiro Iguchi, et al. "Pirfenidone, an Anti-Fibrotic Drug, Suppresses the Growth of Human Prostate Cancer Cells by Inducing G1 Cell Cycle Arrest." Journal of Clinical Medicine 8, no. 1 (2019): 44. http://dx.doi.org/10.3390/jcm8010044.

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Pirfenidone (PFD) is an anti-fibrotic drug used to treat idiopathic pulmonary fibrosis by inducing G1 cell cycle arrest in fibroblasts. We hypothesize that PFD can induce G1 cell cycle arrest in different types of cells, including cancer cells. To investigate the effects of PFD treatment on the growth of human prostate cancer (PCa) cells, we used an androgen-sensitive human PCa cell line (LNCaP) and its sublines (androgen-low-sensitive E9 and F10 cells and androgen-insensitive AIDL cells), as well as an androgen-insensitive human PCa cell line (PC-3). PFD treatment suppressed the growth of all

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Dahiya, Rajvir, Bryan Boyle, Beth Carol Goldberg, et al. "Metastasis-associated alterations in phospholipids and fatty acids of human prostatic adenocarcinoma cell lines." Biochemistry and Cell Biology 70, no. 7 (1992): 548–54. http://dx.doi.org/10.1139/o92-085.

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Metastatic variants of human prostatic adenocarcinoma cell lines (DU-145, LNCaP, and ND-1) were studied by using soft agar colony forming efficiency, nude mice tumorigenicity, in vitro invasion assay, and type IV collagenase assay. The DU-145 and ND-1 cell line snowed higher metastatic potential than LNCaP. Lipids from DU-145, ND-1, and LNCaP cells were extracted and analyzed by thin-layer chromatography and gas-liquid chromatography. The major lipids were phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, fatty acids, and cholesterol. The sphingomyelin level was significantly highe

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Sehgal, I., J. Bailey, K. Hitzemann, M. R. Pittelkow, and N. J. Maihle. "Epidermal growth factor receptor-dependent stimulation of amphiregulin expression in androgen-stimulated human prostate cancer cells." Molecular Biology of the Cell 5, no. 3 (1994): 339–47. http://dx.doi.org/10.1091/mbc.5.3.339.

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Amphiregulin is a heparin-binding epidermal growth factor (EGF)-related peptide that binds to the EGF receptor (EGF-R) with high affinity. In this study, we report a role for amphiregulin in androgen-stimulated regulation of prostate cancer cell growth. Androgen is known to enhance EGF-R expression in the androgen-sensitive LNCaP human prostate carcinoma cell line, and it has been suggested that androgenic stimuli may regulate proliferation, in part, through autocrine mechanisms involving the EGF-R. In this study, we demonstrate that LNCaP cells express amphiregulin mRNA and peptide and that t

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Zafari, Jaber, Hossein Abbasinia, Hediyeh Gharehyazi, Fatemeh Javani Jouni, Saeed Jamali, and Mohammadreza Razzaghi. "Evaluation of Biological Activity of Different Wavelengths of Low-Level Laser Therapy on the Cancer Prostate Cell Line Compared With Cisplatin." Journal of Lasers in Medical Sciences 12, no. 1 (2021): e17-e17. http://dx.doi.org/10.34172/jlms.2021.17.

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Introduction: Cancer is one of the most important problems in the world. Low-level laser therapy (LLLT) has been emerged as a new approach, having both stimulation and inhibition effects on cellular function. The goal of this study was to analyze and compare the different concentrations of cisplatin and wavelengths of laser therapy on the LnCap cell lines. Methods: LnCap cells were cultured and treated with different concentrations of cisplatin (0.1, 0.4, 0.8, 1.2 and 2 µg/mL for 24 hours) and wavelengths of laser therapy (610, 630 and 810 nm) (0.45 J/cm2 ) separately. The viability of cells w

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Kojoeiyan Jafari, Nasim, Hossein Vazini, and Mohammad Taghi Goodarzi. "The Oxidative and Cytotoxic Effects of Resveratrol Compared With Cisplatin in the LNCap Prostate Cancer Cell Line." International Journal of Basic Science in Medicine 7, no. 2 (2022): 61–68. http://dx.doi.org/10.34172/ijbsm.2022.11.

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Introduction: Prostate cancer is one of the most common diseases worldwide, and many efforts are made to treat this disease; however, these efforts seem to be futile. Accordingly, this study tends to compare the cytotoxic and oxidative (as shown by the production of reactive oxygen species (ROS)) effects of resveratrol in comparison with cisplatin in a prostate cancer cell line (LNCap). Methods: After treatment of LNCap cells with the concentrations of 1, 10, 100, 500, and 1000 µg/mL of resveratrol, and 1, 5, 10, and 50 µg/mL of cisplatin, the viability percentage of cells was analyzed using M

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Polek, Tara C., LaMonica V. Stewart, Elizabeth J. Ryu, Michael B. Cohen, Elizabeth A. Allegretto, and Nancy L. Weigel. "p53 Is Required for 1,25-Dihydroxyvitamin D3-Induced G0 Arrest But Is Not Required for G1 Accumulation or Apoptosis of LNCaP Prostate Cancer Cells." Endocrinology 144, no. 1 (2003): 50–60. http://dx.doi.org/10.1210/en.2001-210109.

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Abstract 1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] is an effective agent for inhibiting the growth of prostate cancer cells including LNCaP and PC-3 cell lines. However, the extent of growth inhibition in these cell lines differs because LNCaP cells are much more responsive than PC-3 cells. Previous studies in LNCaP cells have shown that 1,25-(OH)2D3 treatment results in G0/G1 cell cycle accumulation, loss of Ki67 expression, and induction of apoptosis. One difference between the two cell lines is that PC-3 cells lack functional p53, a protein that plays roles both in cell cycle regulation and i

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Phongsuwichetsak, Chayisara, Thummaruk Suksrichavalit, Chawalit Chatupheeraphat, Warawan Eiamphungporn, Sakda Yainoy, and Vichanan Yamkamon. "Diospyros rhodocalyx Kurz induces mitochondrial-mediated apoptosis via BAX, Bcl-2, and caspase-3 pathways in LNCaP human prostate cancer cell line." PeerJ 12 (July 1, 2024): e17637. http://dx.doi.org/10.7717/peerj.17637.

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Background Prostate cancer (PCa) is one of the causes of death in men worldwide. Although treatment strategies have been developed, the recurrence of the disease and consequential side effects remain an essential concern. Diospyros rhodocalyx Kurz, a traditional Thai medicine, exhibits diverse therapeutic properties, including anti-cancer activity. However, its anti-cancer activity against prostate cancer has not been thoroughly explored. This study aims to evaluate the anti-cancer activity and underlying mechanisms of the ethyl acetate extract of D. rhodocalyx Kurz (EADR) related to apoptosis

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van Steenbrugge, G. J., M. Groen, J. W. van Dogen, et al. "The human prostatic carcinoma cell line LNCaP and its derivatives." Urological Research 17, no. 2 (1989): 71–77. http://dx.doi.org/10.1007/bf00262024.

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Negri-Cesi, Paola, and Marcella Motta. "Androgen metabolism in the human prostatic cancer cell line LNCaP." Journal of Steroid Biochemistry and Molecular Biology 51, no. 1-2 (1994): 89–96. http://dx.doi.org/10.1016/0960-0760(94)90119-8.

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Yanish, Yu V., S. P. Zaletok, O. K. Voronina, et al. "THE EFFECT OF PARGILINE, SPERMINE AND THEIR COMBINATIONS ON ANDROGEN-DEPENDENT AND ANDROGEN-INDEPENDENT HUMAN PROSTATE CANCER CELLS in vitro." Oncology 26, no. 3 (2024): 186–96. http://dx.doi.org/10.15407/oncology.2024.03.186.

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Summary. A series of studies on enhancing the cytotoxic effect of spermine on human prostate cells by affecting the enzymes of its metabolism has been continued. Aim: to investigate effects of pargyline, spermine and their combinations the survival, ζ-potential and surface charge and cytomorphological properties of human prostate cancer cells in culture. Object and methods: studies were conducted on cell cultures: differentiated androgen-dependent LNCaP cell line and low-differentiated androgen-independent DU-145 cell line. Cell survival was determined in the trypan blue assay. The effect of t

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Leung, Pak-Shan, William J. Aronson, Tung H. Ngo, Lawrence A. Golding, and R. James Barnard. "Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro." Journal of Applied Physiology 96, no. 2 (2004): 450–54. http://dx.doi.org/10.1152/japplphysiol.00871.2003.

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Epidemiological studies report that regular physical activity can reduce the risk for prostate cancer, the most common solid-tumor cancer in US men. Regular exercise alters the serum IGF axis in vivo and reduces cell proliferation while increasing apoptosis in serum-stimulated LNCaP prostate cancer cells in vitro. The present study tests the hypothesis that these effects on tumor cell lines are mediated by enhancement of the function of the p53 gene known to arrest cell growth and induce apoptosis. When LNCaP cells were cultured in exercise serum and compared with control serum, cell growth wa

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Sanmukh, Swapnil Ganesh, Nilton José dos Santos, Caroline Nascimento Barquilha, et al. "Bacteriophages M13 and T4 Increase the Expression of Anchorage-Dependent Survival Pathway Genes and Down Regulate Androgen Receptor Expression in LNCaP Prostate Cell Line." Viruses 13, no. 9 (2021): 1754. http://dx.doi.org/10.3390/v13091754.

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Wild-type or engineered bacteriophages have been reported as therapeutic agents in the treatment of several types of diseases, including cancer. They might be used either as naked phages or as carriers of antitumor molecules. Here, we evaluate the role of bacteriophages M13 and T4 in modulating the expression of genes related to cell adhesion, growth, and survival in the androgen-responsive LNCaP prostatic adenocarcinoma-derived epithelial cell line. LNCaP cells were exposed to either bacteriophage M13 or T4 at a concentration of 1 × 105 pfu/mL, 1 × 106 pfu/mL, and 1 × 107 pfu/mL for 24, 48, a

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Furlan, Tobias, Florian Handle, Marcus V. Cronauer, and Frédéric R. Santer. "Abstract 2686: Is ARV7 a regulator of prostate cancer stemness and plasticity." Cancer Research 82, no. 12_Supplement (2022): 2686. http://dx.doi.org/10.1158/1538-7445.am2022-2686.

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Abstract Therapy options for advanced and castration-resistant prostate cancer (CRPC) include the use of drugs targeting directly/indirectly the ligand binding domain (LBD) of androgen receptor (AR) such as enzalutamide (Enza) and abiraterone acetate. However, primary or acquired treatment failures are frequently observed and have been associated with the expression of truncated AR variants devoid of the LBD. In particular, the AR variant AR3, also known as ARV7, is detected in over 80% of CRPC specimen and is increasingly expressed in metastatic lesions. In PC models ARV7 expression causes tr

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Salemi, Michele, Filippo Fraggetta, Antonio Galia, et al. "Cerebellar Degeneration-Related Autoantigen 1 (CDR1) Gene Expression in Prostate Cancer Cell Lines." International Journal of Biological Markers 29, no. 3 (2014): 288–90. http://dx.doi.org/10.5301/jbm.5000062.

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Prostate cancer (PCa) is the most frequent cancer among men in many developing countries, and the second leading cause of cancer-related death in men. A genetic component has been implicated in PCa onset and development. The cerebellar degeneration-related autoantigen 1 ( CDR1) gene, mapping in Xq26-q27.2, is expressed in cerebrum, cerebellum, heart, lung, liver, and kidney. In addition, CDR1 expression has been detected in neuroblastoma, renal carcinoma cell lines, and other cancer cell lines. In this study, we investigated the expression of the CDR1 gene in the LNCaP and PC-3 PCa cell lines,

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Mora-Rodríguez, José María, Belén G. Sánchez, Alba Sebastián-Martín, et al. "Resistance to 2-Hydroxy-Flutamide in Prostate Cancer Cells Is Associated with the Downregulation of Phosphatidylcholine Biosynthesis and Epigenetic Modifications." International Journal of Molecular Sciences 24, no. 21 (2023): 15626. http://dx.doi.org/10.3390/ijms242115626.

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In this study, we examined the metabolic adaptations of a chemoresistant prostate cancer cell line in comparison to a sensitive cell line. We utilized prostate cancer LNCaP cells and subjected them to a stepwise increase in the antiandrogen 2-hydroxy-flutamide (FLU) concentration to generate a FLU-resistant cell line (LN-FLU). These LN-FLU cells displayed characteristics of cancer stem cells, exhibited drug resistance, and showed a significantly reduced expression of Cyclin D1, along with the overexpression of p16, pointing to a proliferation arrest. In comparing the cancer stem-like LN-FLU ce

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BAI, GE, SUSAN KASPER, ROBERT J. MATUSIK, PAUL S. RENNIE, JEFFREY A. MOSHIER, and ARNON KRONGRAD. "Androgen Regulation of the Human Ornithine Decarboxylase Promoter in Prostate Cancer Cells." Journal of Andrology 19, no. 2 (1998): 127–35. http://dx.doi.org/10.1002/j.1939-4640.1998.tb01981.x.

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ABSTRACT: We studied the response of the human ornithine decarboxylase (ODC) promoter to androgen in human prostate cancer cell lines. In the well‐differentiated, androgen‐sensitive human prostate cancer line LNCaP, a genomic ODC promoter fragment that includes putative androgen response elements was suppressed by androgen. In contrast, the androgen‐regulated probasin promoter was induced by androgens. The ODC promoter was also induced by cotransfected androgen recepter in the poorly differentiated, androgen‐insensitive human prostate cancer cell line PPC‐1. We examined the effects of cotransf

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32

Emamgholipour, Zahra, Zeinab Hami-Saravani, Heshmatollah Ebrahimi-Najafabadi, Hamidreza Hoveida, and Sara Dabirian. "Designing a Temporin-1CEa Analog with Improved in Vitro Selectivity towards Prostate Cancerous Cell Line (LNCaP)." Acta Scientiarum. Technology 46, no. 1 (2024): e67217. http://dx.doi.org/10.4025/actascitechnol.v46i1.67217.

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Temporins are small antimicrobial peptides which have cytotoxic effects against different cancerous cell lines. However, their cytotoxicity against normal cells has been reported in some studies. Designing new temporin analogs with selective cytotoxicity against cancerous cell lines is considered a goal in drug development. In this regard, four new temporin-1CEa analogs (either C-terminally α-amidated or not) with increased net positive charge, as well as the potential of hydrogen bond formation were designed and their selective cytotoxicity against prostate carcinoma cell line (LNCaP) was eva

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Raitanen, Julia, Bernadette Barta, Marcus Hacker, Dietmar Georg, Theresa Balber, and Markus Mitterhauser. "Comparison of Radiation Response between 2D and 3D Cell Culture Models of Different Human Cancer Cell Lines." Cells 12, no. 3 (2023): 360. http://dx.doi.org/10.3390/cells12030360.

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Radiation therapy is one of the most effective tools in cancer therapy. However, success varies individually, necessitating improved understanding of radiobiology. Three-dimensional (3D) tumor spheroids are increasingly gaining attention, being a superior in vitro cancer model compared to 2D cell cultures. This in vitro study aimed at comparing radiation responses in 2D and 3D cell culture models of different human cancer cell lines (PC-3, LNCaP and T-47D) irradiated with varying doses (1, 2, 4, 6, 8 or 20 Gy) of X-ray beams. Radiation response was analyzed by growth analysis, various cell via

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Szyszka, Marta, Lukasz Paschke, Marianna Tyczewska, et al. "Analysis of Transcriptome, Selected Intracellular Signaling Pathways, Proliferation and Apoptosis of LNCaP Cells Exposed to High Leptin Concentrations." International Journal of Molecular Sciences 20, no. 21 (2019): 5412. http://dx.doi.org/10.3390/ijms20215412.

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Leptin, the first discovered adipokine, has been connected to various physiological and pathophysiological processes, including cancerogenesis. Increasing evidence confirms its influence on prostate cancer cells. However, studies on the effects of leptin on the proliferation and apoptosis of the androgen-sensitive LNCaP line of prostate cancer cells brought conflicting results. Therefore, we performed studies on the effects of high LEP concentration (1 × 10−6 M) on gene expression profile, change of selected signaling pathways, proliferation and apoptosis of LNCaP cells. RTCA (real-time cell a

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Fr�nsdal, Katrine, Nikolai Engedal, and Fahri Saatcioglu. "Efficient DNA-mediated gene transfer into prostate cancer cell line LNCaP." Prostate 43, no. 2 (2000): 111–17. http://dx.doi.org/10.1002/(sici)1097-0045(20000501)43:2<111::aid-pros5>3.0.co;2-4.

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Spans, Lien, Zeynep Kalender Atak, Filip Van Nieuwerburgh, et al. "Variations in the exome of the LNCaP prostate cancer cell line." Prostate 72, no. 12 (2011): 1317–27. http://dx.doi.org/10.1002/pros.22480.

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Leith, John T. "In vitro radiation sensitivity of the lncap prostatic tumor cell line." Prostate 24, no. 3 (1994): 119–24. http://dx.doi.org/10.1002/pros.2990240304.

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Pousette, Åke, Kjell Carlström, Peter Henriksson, Mirtha Grande, and Reinhard Stege. "Use of a hormone-sensitive (LNCaP) and a hormone-resistant (LNCaP-r) cell line in prostate cancer research." Prostate 31, no. 3 (1997): 198–203. http://dx.doi.org/10.1002/(sici)1097-0045(19970515)31:3<198::aid-pros9>3.0.co;2-h.

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Nurmikko, Pauliina, Ville Väisänen, Timo Piironen, Sari Lindgren, Hans Lilja, and Kim Pettersson. "Production and Characterization of Novel Anti-Prostate-specific Antigen (PSA) Monoclonal Antibodies That Do Not Detect Internally Cleaved Lys145-Lys146 Inactive PSA." Clinical Chemistry 46, no. 10 (2000): 1610–18. http://dx.doi.org/10.1093/clinchem/46.10.1610.

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Abstract Background: The nature of free, uncomplexed prostate-specific antigen (PSA) in the circulation is still unknown. In this study, we developed novel anti-PSA antibodies using PSA produced by a metastasized cancer cell line, LNCaP, as an immunogen. Methods: Hybridoma cell lines were screened with different methods that aimed at finding antibodies specific for the forms of free PSA produced by LNCaP cell line. Obtained antibodies were further studied for their characteristics related to previously characterized monoclonal antibodies. Results: Numerous anti-PSA antibodies were obtained, of

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Gao, Bei, Hui-Wen Lue, Jennifer Podolak, et al. "Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma." Metabolites 9, no. 5 (2019): 82. http://dx.doi.org/10.3390/metabo9050082.

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As the most common cancer in men, prostate cancer is molecularly heterogeneous. Contributing to this heterogeneity are the poorly understood metabolic adaptations of the two main types of prostate cancer, i.e., adenocarcinoma and small cell neuroendocrine carcinoma (SCNC), the latter being more aggressive and lethal. Using transcriptomics, untargeted metabolomics and lipidomics profiling on LASCPC-01 (prostate SCNC) and LNCAP (prostate adenocarcinoma) cell lines, we found significant differences in the cellular phenotypes of the two cell lines. Gene set enrichment analysis on the transcriptomi

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Dahut, Madeline, Kristen Fousek, Lucas Horn, Haiyan Qin, Jeffrey Schlom, and Claudia Palena. "727 Resistance to enzalutamide and abiraterone drives tumor phenotypic plasticity and resistance to immune-mediated cytotoxicity." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A757. http://dx.doi.org/10.1136/jitc-2021-sitc2021.727.

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BackgroundBackground: Treatment of patients with castration-resistant prostate cancer (CRPC) includes the use of next-generation hormonal therapies such as abiraterone or enzalutamide. Although these agents extend survival, a significant proportion of patients exhibit primary or acquired resistance to treatment. In recent years, immune checkpoint blockade has led to remarkable responses in patients with several tumor types, however, CRPC has remained resistant to immunotherapy. Previous studies have demonstrated that different tumor variants could emerge along the progression of prostate cance

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Chen, Qi, Zhi-kang Cai, Yan-bo Chen, et al. "Poly r(C) Binding Protein-1 is Central to Maintenance of Cancer Stem Cells in Prostate Cancer Cells." Cellular Physiology and Biochemistry 35, no. 3 (2015): 1052–61. http://dx.doi.org/10.1159/000373931.

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Aims: To investigate global proteomic changes induced in CD44+CD24- stem cells isolated from the prostate cancer cell lines, LNCaP and DU145, post prolonged TGF-β treatment in order to understand underlying mechanisms that promote stemness in prostate cancer cells. Methods: CD44+CD133+α2β1Integrin+CD24- population was isolated from mock or TGF-β treated (7 days) prostate cancer cell line, LNCaP, through fluorescent activated cell sorting. Cell lysates were obtained from the ±TGF-β cell population and proteomics profiling (MS/MS) was performed by mass spectrometry. Relative enrichment or deplet

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Özgönül, Ali Mert, Aycan Aşık, Burak Durmaz, Ramin Aslaminabad, Cumhur Gündüz, and Eser Yıldırım Sozmen. "Antiproliferative effect of rosehip tea phenolics in prostate cancer cell lines." Turkish Journal of Biochemistry 45, no. 4 (2020): 423–28. http://dx.doi.org/10.1515/tjb-2019-0262.

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AbstractObjectivesRecently, phenolic compounds (quercetin, kaempferol, ellagic acid (EA), and myricetin) as natural sources have been suggested to be used for treatment and chemoprevention of prostate cancer. Since rosehip includes the above molecules in high concentration, we set out to investigate possible anti-proliferative effect of rosehip tea on the prostate cancer cell line.MethodsThe flavonol content of rosehip tea prepared at different temperatures and time intervals was determined first and then the antiproliferative effect of tea samples was established by adding tea samples to the

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Runge, Roswitha, Anne Naumann, Matthias Miederer, Joerg Kotzerke, and Claudia Brogsitter. "Up-Regulation of PSMA Expression In Vitro as Potential Application in Prostate Cancer Therapy." Pharmaceuticals 16, no. 4 (2023): 538. http://dx.doi.org/10.3390/ph16040538.

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Possibilities to improve the therapeutic efficacy of Lu-177–PSMA-617 radionuclide therapy by modulation of target expression are being investigated. Knowledge on regulatory factors that promote prostate cancer (PCa) progression may contribute to targeting prostate cancer more effectively. We aimed at the stimulation of PCa cell lines using the substances 5-aza-2′-deoxycitidine (5-aza-dC) and valproic acid (VPA) to achieve increased prostate-specific membrane antigen (PSMA) expression. PC3, PC3-PSMA, and LNCaP cells were incubated with varying concentrations of 5-aza-dC and VPA to investigate t

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Tsvetankova, Radostina, Ilka Tsvetkova, Albena Apostolova, Soren Hayrabedyan, and Krassimira Todorova. "Combined microRNA-141 Rescue and MAPK1 Silencing as Putative Strategy to Support Chemotherapy in Translational Stage towards Metastatic Castration-resistant Prostate Cancer – an In Vitro Model Study." Proceedings of the Bulgarian Academy of Sciences 76, no. 8 (2023): 1286–96. http://dx.doi.org/10.7546/crabs.2023.08.15.

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Tumourigenesis is associated with disruption of cell differentiation, proliferation, migration, and abnormal DNA methylation. Deregulation of transcription factors MAPK1 and NF-κB and other post modification factors play an important role in these processes. Using AR-positive and AR-negative cell line models (LNCaP-p53+/+ and PC3-p53-/-), we found MAPK1 siRNA silencing as potentially productive approach to decrease castration-resistant cell line invasiveness, but not sufficient to abrogate anti-apoptotic, pro-inflammatory by NF-κB signalling, and so we combined this approach with miR-141 rescu

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Guerriero, Ilaria, Håkon Ramberg, Krizia Sagini, Manuel Ramirez-Garrastacho, Kristin A. Taskén та Alicia Llorente. "Implication of β2-adrenergic receptor and miR-196a correlation in neurite outgrowth of LNCaP prostate cancer cells". PLOS ONE 16, № 6 (2021): e0253828. http://dx.doi.org/10.1371/journal.pone.0253828.

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The β2-adrenergic receptor has been shown to be involved in neuroendocrine differentiation and to contribute to the development of aggressive prostate cancer. In this study we have investigated whether miR-196a plays a role in the regulation of the β2-adrenergic receptor in the LNCaP prostate cancer cell line. Our results show that the expression of miR-196a is elevated in LNCaP prostate cancer cells with reduced levels of β2-adrenergic receptor after stably transfection with three different shRNAs. Furthermore, treatment with β-blockers showed that this upregulation is strictly related to the

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Efferson, Clay L., Naotake Tsuda, Kouichiro Kawano, et al. "Prostate Tumor Cells Infected with a Recombinant Influenza Virus Expressing a Truncated NS1 Protein Activate Cytolytic CD8+ Cells To Recognize Noninfected Tumor Cells." Journal of Virology 80, no. 1 (2006): 383–94. http://dx.doi.org/10.1128/jvi.80.1.383-394.2006.

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ABSTRACT Many viral oncolytic approaches against cancer are based on the ability of specific viruses to replicate in tumors expressing components of the constitutively activated Ras/mitogen-activated protein kinase (MAPK) pathways and/or inhibited or dysregulated alpha/beta interferon (IFN-α/β) response pathways. A major issue when considering these approaches is their applicability to tumors that lack activated Ras. To identify the effector mechanisms activated by oncolytic viruses, we investigated inhibition of proliferation of the prostate cancer line LNCap by the recombinant TR-NS1 influen

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Kovalenko, P. L., and M. D. Basson. "Exogenous Schlafen 12 Expression In The Lncap Prostate Cancer Cell Line Modulates Cell Differentiation." Journal of Surgical Research 186, no. 2 (2014): 683. http://dx.doi.org/10.1016/j.jss.2013.11.949.

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Gonen, Ceren. "PMA Induction to Prostate Cancer Cell Lines: DU145 and LNCAP." Journal of Biomedical Engineering and Medical Imaging 11, no. 5 (2024): 86–94. https://doi.org/10.14738/bjhmr.115.17644.

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Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer mortality in men in the Western World. The effects of androgens are mediated by the Androgen Receptor (AR). Therefore, studies focus on the identification of AR-regulated genes that are also highly expressed in the prostate. STAMP family genes STAMP1/STEAP2 and STAMP2/STEAP4 have only expressed in androgen receptor-positive cells, the role of AR in STAMP family gene expression is an important question Phorbol 12-myristate 13-acetate, NF-κB Activator, PMA, TPA PMA is used at 100nM final concentration af

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Chouinard, Sarah, Olivier Barbier, and Alain Bélanger. "UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 Enzymes Are Major Determinants of the Androgen Response in Prostate Cancer LNCaP Cells." Journal of Biological Chemistry 282, no. 46 (2007): 33466–74. http://dx.doi.org/10.1074/jbc.m703370200.

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Uridine diphosphate-glucuronosyltransferase 2 (UGT2)B15 and B17 enzymes conjugate dihydrotestosterone (DHT) and its metabolites androstane-3α, 17β-diol (3α-DIOL) and androsterone (ADT). The presence of UGT2B15/B17 in the epithelial cells of the human prostate has been clearly demonstrated, and significant 3α-DIOL glucuronide and ADT-glucuronide concentrations have been detected in this tissue. The human androgen-dependent cancer cell line, LNCaP, expresses UGT2B15 and -B17 and is also capable of conjugating androgens. To assess the impact of these two genes in the inactivation of androgens in

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