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Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Samarasekera, Neshika Erangi. "Does lobar intracerebral haemorrhage differ from non-lobar intracerebral haemorrhage?" Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/15836.

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Spontaneous (non-traumatic) intracerebral haemorrhage accounts for ~10% of all strokes in Western populations. Investigations may identify intracerebral haemorrhage (ICH) as ‘secondary’ to underlying causes such as tumours or aneurysms, but ~80% of ICHs which have no apparent underlying cause (so-called ‘primary’ ICH) tend to be attributed to small vessel vasculopathies such as arteriolosclerosis or cerebral amyloid angiopathy (CAA), on the basis of an adult’s risk factors and clinical and radiographic features of the ICH. The commonly accepted hypothesis is that CAA contributes to lobar ICH a

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Skoglund, Lena. "Molecular Mechanisms of Frontotemporal Lobar Degeneration." Doctoral thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9550.

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The aim of this thesis was to identify genetic factors involved in frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder clinically characterised by a progressive change in personality, behaviour and language. FTLD is a genetically complex disorder and a positive family history is found in up to 40% of the cases. In 10-20% of the familial cases the disease can be explained by mutations in the gene encoding the microtubule associated protein tau (MAPT). In the first study we describe the clinical and neuropathological features of a Finnish family with FTLD caused by a mutation

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Omar, R. "Nonverbal processing in frontotemporal lobar degeneration." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1381829/.

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Frontotemporal lobar degeneration (FTLD) refers to a group of diseases characterised by focal frontal and temporal lobe atrophy that collectively constitute a substantial source of clinical and social disability. Patients exhibit clinical syndromes that are dominated by a variety of nonverbal cognitive and behavioural features such as agnosias, altered emotional and social responses, impaired regulation of physiological drives, altered chemical sense, somatosensory and interoceptive processing. Brain mechanisms for processing nonverbal information are currently attracting much interest in the

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Rohrer, J. D. "Language impairment in frontotemporal lobar degeneration." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/516148/.

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The term frontotemporal lobar degeneration (FTLD) describes a heterogeneous group of neurodegenerative disorders associated with frontal and temporal lobe atrophy. Within this spectrum, two progressive aphasia syndromes, progressive nonfluent aphasia (PNFA) and semantic dementia (SD), are well described. FTLD is commonly a genetic disorder and mutations in two genes, microtubule-associated protein tau (MAPT) and progranulin (GRN) account for a large proportion of familial cases. A retrospective imaging study using cortical thickness measures shows involvement of the anteroinferior temporal lob

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Clark, C. N. "Social signal decoding in frontotemporal lobar degeneration." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1508105/.

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Frontotemporal lobar degeneration (FTLD) is associated with progressive social cognitive impairment. Currently a comprehensive pathophysiological model allowing disease effects to be understood and anticipated at the level of the whole brain is lacking. In this thesis I explored candidate cognitive operations underpinning complex behaviours in patients with the canonical syndromes of FTLD; behavioural variant frontotemporal dementia (bvFTD) and semantic dementia (SD). I correlated behavioural deficits with brain network disintegration using the structural magnetic resonance imaging (MRI) techn

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Suhonen, N. M. (Noora Maria). "Cognitive and behavioral characteristics of frontotemporal lobar degeneration." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526216102.

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Abstract Frontotemporal lobar degeneration (FTLD) is the second commonest cause of dementia after Alzheimer’s disease (AD) in patients <65 years. Its most frequent clinical subtype is behavioral variant frontotemporal dementia (bvFTD) characterized by behavioral change and executive deficits. FTLD also encompasses two variants of primary progressive aphasia (PPA) characterized by language deficits. The majority of familial FTLD cases are linked to the C9ORF72 expansion mutation. As both cognitive and behavioral changes are core diagnostic features of FTLD, neuropsychological assessment is v

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Cooper, P. N. "Pathological changes in dementia due to lobar atrophy." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359985.

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Lansdall, Claire Jade. "Apathy and impulsivity in frontotemporal lobar degeneration syndromes." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/268020.

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There has been considerable progress in the clinical, pathological and genetic fractionation of frontotemporal lobar degeneration syndromes in recent years, driving the development of novel diagnostic criteria. However, phenotypic boundaries are not always distinct and syndromes converge with disease progression, limiting the insights available from traditional diagnostic classification. Alternative transdiagnostic approaches may provide novel insights into the neurobiological underpinnings of symptom commonalities across the frontotemporal lobar degeneration spectrum. In this thesis, I illust

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9

Beaumont, Helen. "Multimodal magnetic resonance imaging of frontotemporal lobar degeneration." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/multimodal-magnetic-resonance-imaging-of-frontotemporal-lobar-degeneration(937c1e41-ba17-4ec6-8c6e-c15e06d9429b).html.

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Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of illnesses which can be difficult to diagnose. Modern diagnostic criteria require the presence of imaging abnormalities, but these are not always seen in the early stages of the illness. Hence there is a need to consider the use of more advanced MR techniques. This thesis reports the results of a multimodal MRI study of patients with FTLD, and considers two things: how well data from the different modalities can classify patients, and how well the different modalities can identify affected tissue. FTLD is thought to involve al

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10

Kaivorinne, A. L. (Anna-Lotta). "Frontotemporal lobar degeneration in Finland:molecular genetics and clinical aspects." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789526200132.

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Abstract Frontotemporal lobar degeneration (FTLD) is the second most common neurodegenerative disease leading to early-onset dementia (< 65 years), next to Alzheimer’s disease. FTLD is substantially a genetic disorder with up to 50% of cases having a positive family history. Mutations in the genes microtubule-associated protein tau (MAPT) and progranulin (PGRN) account for about 10–20% of all cases of FTLD. Hexanucleotide repeat expansion mutation within the gene C9ORF72 has recently been identified as the major cause of FTLD, FTLD with amyotrophic lateral sclerosis (ALS) and pure ALS

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11

Krüger, J. (Johanna). "Molecular genetics of early-onset Alzheimer's disease and frontotemporal lobar degeneration." Doctoral thesis, University of Oulu, 2010. http://urn.fi/urn:isbn:9789514263156.

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Abstract Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) are the two most common neurodegenerative diseases leading to early onset dementia (< 65 years). Mutations in the amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes cause a proportion of familial early-onset AD (eoAD), while the microtubule-associated protein tau (MAPT) and progranulin (PGRN) mutations have been identified in FTLD patients. Only a few PSEN1 and APP mutations have previously been found in Finnish AD patients, and one MAPT mutation in a FTLD family, while the role

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12

Illán, Gala Ignacio. "Pathophysiological and structural underpinnings of frontotemporal lobar degeneration: a multimodal biomarker study." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667265.

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La degeneración Lobular Frontotemporal (DLFT) es una constructo neuropatológico heterogéneo que incluye diferentes entidades neuropatológicas caracterizadas por una neurodegeneración prominente de los lóbulos frontales y temporales. A pesar de que algunos síndromes clínicos han demostrado predecir el diagnóstico neuropatológica de DLFT, la capacidad de los síndromes clínicos para predecir el diagnóstico neuropatológico es limitada. En esta tesis nos propusimos profundizar en los fundamentos fisiopatológicos y estructurales de la neurodegeneración relacionada con la DLFT mediante un estudio de

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13

Andrés, Benito Pol. "Novel molecular alterations in amyotrophic lateral sclerosis and frontotemporal lobar degeneration spectrum." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668320.

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Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are clinically distinct neurodegenerative diseases that are connected by genetic and pathological overlap. ALS patients present with muscle weakness and spasticity associated with degeneration of motor neurons in the motor cortex, brainstem, and spinal cord that ultimately leads to death. In contrast, patients with FTLD display cognitive dysfunction associated with degeneration of neurons in the frontal and temporal lobes of the brain. Despite being clinically distinct, 15% of individuals presenting FTLD also have

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14

Carmona, Iragui María. "Sporadic cerebral amyloid angiopathy, beyond lobar intracerebral hemorrhage: multimodal biomarker studies of atypical presentations." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/456561.

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La angiopatía amiloide cerebral (CAA) se define por el depósito de proteína β-amiloide en las capas media y adventicia de arterias y capilares leptomeníngeos y corticales. Es una causa importante de hemorragia intracerebral lobar, episodios neurológicos focales transitorios y contribuye significativamente al deterioro cognitivo y a la demencia en los ancianos. Los principales correlatos neurorradiológicos en resonancia magnética son los microsangrados córtico-subcorticales y la siderosis superficial cortical. Sin embargo, la CAA está asociada con un amplio espectro de fenotipos clínico-radioló

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15

Whitwell, Jennifer Louise. "MR-based volumetric measurements in frontotemporal lobar degeneration : application to diagnosis and measurement of progression." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445955/.

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This thesis investigates the role of volumetric MRI in the diagnosis and measurement of progression in patients with frontotemporal lobar degeneration (FTLD). Patterns of regional atrophy were assessed cross-sectionally using both visual ratings and the automated unbiased technique of voxel-based morphometry (VBM). Both techniques identified characteristic patterns of atrophy in FTLD, and its syndromic variants. In addition, a network of structures was identified that may contribute to the behavioural abnormalities observed in FTLD patients. Detailed regional volumetric measurements of tempora

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16

Fasanella, Regiane de Souza. "Habilidades de comunicação nas demências avançadas." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5162/tde-08122011-162856/.

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INTRODUÇÃO: O aumento da expectativa de vida tem contribuído para o crescimento da população idosa em todo o mundo. O envelhecimento é uma condição de risco para o desenvolvimento de doenças, entre as quais as demências, que responderão nas próximas décadas por um número significativo de idosos com comprometimento cognitivo, comportamental e funcional. A ampliação de cuidados a esses pacientes está associada ao aumento de sua expectativa de vida; por isso é crescente o número de indivíduos dementes em estágios avançados. Os quadros demenciais comprometem gradualmente o comportamento e a cogniç

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17

Hernández, Ruiz Mª Isabel. "Factores genéticos asociados a la degeneración lobar frontotemporal. Análisis de susceptibilidad genética y correlación fenotipo-genotipo." Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/285735.

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La Degeneración Lobar Frontotemporal es un grupo heterogéneo de enfermedades, la segunda causa más frecuente de demencia en edad presenil y la que presenta el mayor número de casos hereditarios. Se caracteriza por una gran variabilidad clínica, genética e histopatológica. Las personas afectas pueden presentar síntomas que abarcan desde los trastornos de conducta hasta las diferentes alteraciones del lenguaje, con o sin enfermedad de motoneurona o parkinsonismo asociado. La atrofia en los lóbulos frontales y temporales es el hallazgo radiológico más relevante. En los últimos 10 años, el conoc

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18

Andersen, N. Christian. "On characterisation and diagnosis of frontotemporal lobar degeneration syndromes : with special reference to the progressive aphasias /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-325-2.

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Lladó, Plarrumaní Albert. "Implicación de los genes MAPT y PGRN en la degeneración lobar frontotemporal: mecanismos patgénicos y expresión fenotípica." Doctoral thesis, Universitat de Barcelona, 2008. http://hdl.handle.net/10803/2240.

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Este trabajo se centra en el estudio de la implicación de los genes MAPT y PGRN en la degeneración lobar frontotemporal (DLFT). <br/>Se describen 2 nuevas mutaciones en estos genes (P301T en el gen MAPT y la A303AfsX57 en el gen PGRN) y no se encontraron variaciones en el número de copias del gen MAPT en las muestras estudiadas, apoyando que la existencia de alteraciones en la dosis génica de MAPT no seria una causa de DLFT. El mecanismo patogénico de la mutación P301T es potencialmente múltiple e incluye la reducción de la capacidad de promover el ensamblaje entre tau y los microtúbulos, la e

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20

Kornfield, James M. "TDP-43 proteinopathy: tracing the roots of a newly classified neurodegenerative disease." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21197.

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Thesis (M.A.)PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>TAR DNA Binding Protein-43 (TDP-43) proteinopathy is a disease pathology that underlies a broad field of neurodegenerative disorders. Most prominently, TDP-43 aggregates are the hallmark of Amyotrophic Lateral Sclerosis (ALS) and Fr

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21

Takada, Leonel Tadao. "Pesquisa de mutações do gene GRN e dosagem plasmática de progranulina em casuística brasileira de degeneração lobar frontotemporal." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-11092015-154947/.

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Introdução: A demência frontotemporal (DFT) inclui a variante comportamental da demência frontotemporal (vcDFT), a variante semântica da afasia progressiva primária (vsAPP), e a variante não fluente da APP (vnfAPP). Os genes em que são encontradas mutações causadoras de DFT mais frequentemente são: GRN (que codifica a progranulina), MAPT (que codifica a proteína tau) e C9orf72. Métodos: Foram incluídos probandos diagnosticados com vcDFT, vsAPP ou vnfAPP, com base com os critérios diagnósticos mais recentes, e um grupo de indivíduos cognitivamente normais. Os éxons 2-12 de GRN e os éxons 1, 9-1

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Silva, Wesley Gomes da. "Banco de Cérebros do Brasil Central (BCBC): prevalência de demências e correlação clínico-patológica." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/5794.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-02T14:17:31Z No. of bitstreams: 2 Tese - Wesley Gomes da Silva - 2016.pdf: 5910954 bytes, checksum: 7d938f9383af006973baacbf56b71a52 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-02T14:19:57Z (GMT) No. of bitstreams: 2 Tese - Wesley Gomes da Silva - 2016.pdf: 5910954 bytes, checksum: 7d938f9383af006973baacbf56b71a52 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Made available in DSpa

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Soares, Cândida Dias. "Perfil neurolinguístico comparativo das demências tipo Alzheimer e não Alzheimer." Universidade Federal de Goiás, 2010. http://repositorio.bc.ufg.br/tede/handle/tede/4928.

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Submitted by Cláudia Bueno (claudiamoura18@gmail.com) on 2015-11-18T18:39:05Z No. of bitstreams: 2 Dissertação - Cândida Dias Soares - 2010.pdf: 1198463 bytes, checksum: acc22e0252670b4f6969e526efca18eb (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-11-19T14:26:37Z (GMT) No. of bitstreams: 2 Dissertação - Cândida Dias Soares - 2010.pdf: 1198463 bytes, checksum: acc22e0252670b4f6969e526efca18eb (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>M

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Hu, Quan. "The molecular pathology, genetic involvement and biochemical characteristics of fused in sarcoma (FUS) protein and chromosome 9p-linked frontotemporal lobar degeneration." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/the-molecular-pathology-genetic-involvement-and-biochemical-characteristics-of-fused-in-sarcoma-fus-protein-and-chromosome-9plinked-frontotemporal-lobar-degeneration(4ac87100-f73a-41c9-a921-f6af5d54dd27).html.

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The fused in sarcoma (FUS) protein has been shown to be a significant disease protein in a subgroup of patients with frontotemporal lobar degeneration (FTLD). Nevertheless, the mechanism underlying FUS associated FTLD is only poorly understood. Recent research has identified a large hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72), reinforcing the association between C9orf72 and FTLD. Moreover, an unusual histopathological change has been observed within the granule cell layer of the cerebellum in chromosome 9p-linked frontotemporal dementia with motor neuron dis

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Solchenberger, Barbara [Verfasser], and Christian [Akademischer Betreuer] Haass. "Generation of granulin knock out zebrafish models for frontotemporal lobar degeneration and related disorders by genome editing / Barbara Solchenberger. Betreuer: Christian Haass." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1080663258/34.

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Costa, Thaís Virgínia Moura Machado. "Análise da presença de mutação no gene TARDBP em pacientes com degeneração lobar frontotemporal e implementação de metodologia para determinação dos polimorfismos do gene APOE em pacientes com Doença de Alzheimer em São Paulo - SP." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-02102012-084400/.

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Atualmente, as demências tornam-se mais prevalentes e constituem-se como um importante problema de saúde pública mundial. A Degeneração Lobar Frontotemporal (DLFT) e a Doença de Alzheimer (DA) são as de maior incidência. A investigação dos fatores de risco para as demências degenerativas inscreve-se entre os temas mais relevantes das neurociências e a avaliação dos fatores de risco de natureza genética tem produzido contribuições importantes. Na DLFT, mutações no gene TARDBP, codificador da proteína nuclear TDP-43, estão entre as ocorrências genéticas mais descritas, enquanto que para a DA, o

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LaMarre, Amanda Kathleen. "Exploring the relationship between psychopathic personality traits and executive function task ability in young adults and adults genetically at-risk for frontotemporal lobar dementia." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/16836.

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The construct of impulsivity plays an important role in personality theory, and is related to cognitive processes subsumed under the heading of executive functions. Moreover, a relationship appears to exist such that individual differences in executive function coincide with variations in impulsive personality traits. The prefrontal cortex has been proposed to be the neuroanatomical site which orchestrates the relationship between both personality and higher-order cognition. Psychopathologies and neurological disorders which display high levels of impulsivity and prefrontal cortex dysfunctio

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Caroppo, Paola. "Study of the clinical and preclinical stages of genetic forms of frontotemporal lobar degeneration (FTLD) and research of biomarkers of progression of the disease." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066116.

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Les dégénérescences lobaires fronto-temporale (DLFT) sont des démences neurodégénératives rares. 30-50% des DLFT a une cause génétique, la plupart sont des mutations des gènes C9orf72 et progranuline (GRN). L'objectif de la thèse a été d'élargir le spectre mutationnel et phénotypique des mutations GRN. Nous avons identifié les premières délétions partielles du gène GRN chez des patients avec progranulinémie baisse (la progranulinémie est abaissée en cas de mutation), mais sans mutation détectée par séquençage. Nous avons contribué à élargir le spectre clinique de la maladie en décrivant un phé

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Islam, Mohammad Saidul. "Three-dimensional modelling of particulate deposition in the human respiratory tract." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/115472/1/115472_9028200_mohammad_saidul_islam_thesis.pdf.

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This study is the first-ever approach to simulate particulate matter transport and deposition in the terminal bronchioles of the 17-generation, whole lung model by considering a possible entire branching pattern. The anatomically explicit, digital 17-generation conduit model is generated from the high-resolution CT data. A comprehensive size- and shape-specific particle transport and deposition study is performed for different physical conditions and finds a new deposition pattern for a realistic anatomical model. The present findings would potentially help the targeted drug delivery system de

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Silva, Thais Bento Lima da. "Validação da escala de estadiamento e progressão da demência frontotemporal (FTD-FRS)." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-09052018-111153/.

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Introdução: No Brasil há carência de instrumentos validados para a análise do curso da Demência Frontotemporal (DFT). Dessa forma, torna-se relevante a validação da Escala de Estadiamento e Progressão da Demência Frontotemporal (FTD-FRS). Em nosso meio, as escalas de estadiamento das demências, como a Clinical Dementia Rating (CDR), foram elaboradas para graduar a doença de Alzheimer (DA) e não incluem os sintomas específicos da DFT. Objetivos: 1. Realizar a tradução, adaptação transcultural e validação da FTD-FRS para o contexto brasileiro. 2. Avaliar a capacidade da FTD-FRS detectar alteraçõ

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Lang, Christina [Verfasser], and Christian [Akademischer Betreuer] Haass. "Transmembrane protein 106B, a risk factor in frontotemporal lobar degeneration, is a lysosomal type II transmembrane protein and affects autophagy / Christina Lang. Betreuer: Christian Haass." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1095484575/34.

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Cone, Alan J. "Fission Yeast as a Model Organism for FUS-Dependent Cytotoxicity in Amyotrophic Lateral Sclerosis." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1470750088.

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Dukart, Jürgen. "Contribution of FDG-PET and MRI to improve Understanding, Detection and Differentiation of Dementia." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-66495.

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Progression and pattern of changes in different biomarkers of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) like [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) have been carefully investigated over the past decades. However, there have been substantially less studies investigating the potential of combining these imaging modalities to make use of multimodal information to further improve understanding, detection and differentiation of various dementia syndromes. Further the role of preprocessing has been rarely addres

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Souza, Marilda Aparecida do Nascimento. "Prevalência de historia familiar positiva em portadores de síndromes degenerativas demenciantes." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/7010.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2017-03-27T13:27:24Z No. of bitstreams: 2 Dissertação - Marilda Aparecida do Nascimento Souza - 2016.pdf: 2356436 bytes, checksum: a957e23bb1a3bdd13c4601abcd76f854 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-03-27T13:28:08Z (GMT) No. of bitstreams: 2 Dissertação - Marilda Aparecida do Nascimento Souza - 2016.pdf: 2356436 bytes, checksum: a957e23bb1a3bdd13c4601abcd76f854 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9

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35

Fourier, Anthony. "Vers un marqueur biochimique des dégénérescences lobaires fronto-temporales : variations quantitatives et profils protéiques de la protéine TDP43 dans différentes matrices biologiques." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1269/document.

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Les dégénérescences lobaires frontotemporales (DLFT) représentent la deuxième étiologie neurodégénérative chez l’adulte de moins de 65 ans. Les DLFT sont constituées d’un ensemble hétérogène de phénotypes cliniques et sont fréquemment héréditaires. Leurs particularités neuropathologiques communes reposent sur une atrophie des lobes frontaux et/ou temporaux associée à la présence d’inclusions de protéines agrégées parmi lesquelles la protéine TAR DNA binding protein 43 (TDP43). Actuellement, aucun marqueur protéique n’est validé pour diagnostiquer les DLFT du vivant du patient.Une cohorte de ca

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RIZ, M. A. DE. "FATTORI DI RISCHIO GENETICI NELLA MALATTIA DI ALZHEIMER E NELLA DEMENZA FRONTOTEMPORALE: STUDIO DI ASSOCIAZIONE DI GENI CANDIDATI POSIZIONALI E FUNZIONALI." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/150554.

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Alzheimer’s disease (AD) and Frontotemporal Lobar Degeneration (FTLD) are two neurodegenerative and multifactorial diseases with complex etiology in which several genes involved in inflammation, oxidative damage and neuronal survival have been proposed to be candidate susceptibility factors. Given these premises, aims of this study have been to further analyze the association of candidate functional and positional genes in a population of 374 patient with AD, 291 with FTLD and 344 age matched controls. The first candidates studied have been the cell-dependent kinase inhibitor (CDKN) 2A and 2

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Rodrigues, Carlos. "Dor crónica lombar." Master's thesis, Escola Superior de Saúde, 2011. http://hdl.handle.net/10400.26/4196.

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Dissertação de Mestrado em Fisioterapia, área de especialização em Condições Músculo-Esqueléticas<br>A dor crónica lombar, é uma condição de saúde cuja prevalência tem aumentado nas últimas décadas. É uma condição que pode ser bastante incapacitante para o indivíduo e por consequência, ter importante impacto social e económico na sociedade. É um fenómeno complexo, multifactorial e pouco estudado na população portuguesa. Objectivo: Estudar a associação entre a catastrofização da dor, crenças de medo evitamento da dor, intensidade da dor e a incapacidade funcional auto reportada em indivíduos co

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Jeremias, A. Teresa. "Dor crónica lombar." Master's thesis, Instituto Politécnico de Setúbal. Escola Superior de Saúde, 2013. http://hdl.handle.net/10362/15205.

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RESUMO: A Dor Crónica Lombar (DCL) não especifica é entendida como, presença de dor persistente na região lombar, com duração de pelo menos 12 semanas ou presença de recorrências de dor por um período de seis meses, sem causa física específica, isto é, de origem desconhecida (Airaksinen, et al., 2006; Bekkering et al., 2003; Krismer & van Tulder, 2007). Em Portugal, 36% de pessoas referem dor crónica, sendo que em 40% destes casos são relativos a dor crónica lombar (Faculdade de Medicina da Universidade do Porto, 2007 cit. por APED, 2007 e Castro-Lopes, Saramago, Romão & Paiva, 2010). A frequ

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Girard, Julien N. "Développement de la Super Station LOFAR & observations planétaires avec LOFAR." Phd thesis, Observatoire de Paris, 2013. http://tel.archives-ouvertes.fr/tel-00835834.

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Les développements techniques récents en radioastronomie au sol ont permis l'émergence de nombreux nouveaux projets. LOFAR (le "LOw Frequency ARray") est un interféromètre de réseaux phasés comptant parmi ces nouveaux radiotélescopes géants. Son architecture distribuée à travers l'Europe comprend plusieurs milliers d'éléments regroupés en "stations". Il permet d'étudier l'Univers dans la fenêtre radio ~20-250 MHz, inexplorée avec une très haute sensibilité et de très hautes résolutions angulaire, temporelle et spectrale. La station LOFAR de Nançay a permis à la communauté française de particip

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Girard, Julien. "Développement de la Super Station LOFAR & observations planétaires avec LOFAR." Observatoire de Paris, 2013. https://theses.hal.science/tel-00835834.

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Les développements techniques récents en radioastronomie au sol ont permis l'émergence de nombreux nouveaux projets. LOFAR (le "LOw Frequency ARay") est un interféromètre de réseaux phasés comptant parmi ces nouveaux radiotélescopes géants. Son architecture distribuée à travers l'Europe comprend plusieurs milliers d'éléments regroupés en "stations". Il permet d'étudier l'Univers dans la fenêtre radio ~20-250 MHz, inexploré avec une très haute sensibilité et de très hautes résolutions angulaire, temporelle et spectrale. La station LOFAR de Nançay a permis à la communauté française de participer

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41

Marin, Sheilla de Medeiros Correia. "Avaliação fonoaudiológica da deglutição na demência frontotemporal." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5162/tde-26082014-111637/.

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Introdução: A deglutição e suas características principais ainda são desconhecidas na demência frontotemporal. Objetivos: Caracterizar a deglutição e o comportamento alimentar de pacientes com diagnóstico de demência frontotemporal que apresentam a variante comportamental (DFTvc) e a afasia progressiva primária (APP). Caracterizar os pacientes com DFT e seus cuidadores. Descrever aspectos cognitivos e comportamentais, funcionalidade global, comunicação funcional, e a funcionalidade da deglutição na DFT. Descrever os problemas de deglutição e do comportamento alimentar na DFTvc e APP. Correlaci

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Hassall, Tom. "Observing pulsars with LOFAR." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/observing-pulsars-with-lofar(1860a120-1c7a-4d64-a281-f482f3f53614).html.

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The LOw Frequency ARray (LOFAR) is the first of a new generation of telescopes which, instead of using a single large dish, will combine the signals from thousands of antennas. Combining these signals creates a virtual beam, which can be 'pointed' like traditional (dish-like) telescopes, but with significantly improved angular resolution and sensitivity at low frequencies. This unique configuration also allows LOFAR to observe in several modes which are not possible with other telescopes, including forming multiple beams, and simultaneously taking imaging and beam-formed data. In this thesis w

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43

França, Fabio Jorge Renovato. "Estabilização segmentar lombar e TENS na hérnia discal lombar: um ensaio clínico randomizado." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-26052014-103540/.

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INTRODUÇÃO: A hérnia de disco lombar (HDL) acomete cerca de 5% dos pacientes com de dor lombar e o tratamento cirúrgico nestes casos é cada vez menos indicado, optando-se, na maior parte dos casos, pelo conservador. Embora o método estabilização lombar (EL) e a estimulação elétrica nervosa transcutânea (TENS) tenham mostrado bons resultados em indivíduos portadores de dor lombar inespecífica, há escassa literatura que tenha verificado a eficácia destes tratamentos isoladamente em sujeitos acometidos por hérnia de disco lombar. OBJETIVO: Comparar a eficácia dos exercícios de estabilização lomba

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Moraes, Antonio Carlos de 1960. "Resposta eletromiografica do musculo iliocostal lombar e abordagem da pressão intradiscal da coluna lombar." [s.n.], 1999. http://repositorio.unicamp.br/jspui/handle/REPOSIP/274889.

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Orientador: Antonia Dalla Pria Bankoff<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Educação Fisica<br>Made available in DSpace on 2018-07-25T14:26:56Z (GMT). No. of bitstreams: 1 Moraes_AntonioCarlosde_D.pdf: 4286370 bytes, checksum: 1b049090df93f8356cbe9612c8e178ca (MD5) Previous issue date: 1999<br>Resumo: A ação dos músculos extensores da coluna tem sido estudada através da eletromiografia com o intuito de conhecer a participação muscular durante várias posturas corporais, as quais tentam assemelhar-se às posições assumidas pelo corpo humano durante as atividades

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45

Teyssou, Elisa. "Analyses génétiques et fonctionnelles de nouveaux gènes incriminés dans la Sclérose Latérale Amyotrophique (SLA) Genetic analysis of matrin 3 gene in French amyotrophic lateral sclerosis patients and frontotemporal lobar degeneration with amyotrophic lateral sclerosis patients Genetic analysis of CHCHD10 in French familial amyotrophic lateral sclerosis patients." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066738.

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La Sclérose Latérale Amyotrophique (SLA) est une maladie neurodégénérative fatale caractérisée par la dégénérescence des motoneurones centraux et périphériques. Elle est le plus souvent sporadique (SALS, 90% des cas), tandis que les formes familiales (FALS) représentent 10% des patients. Une vingtaine de gènes liés à la SLA ont été identifiés et sont responsables de 70% des FALS et 10% des SALS. Le but de ce projet était d’étudier la contribution de 6 gènes rares dans une large cohorte de patients français atteints de SLA et d’étudier les conséquences fonctionnelles de certains variants identi

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Viotti, Olle. "Håller vindkraften vad den lovar?" Thesis, Uppsala universitet, Institutionen för fysik och astronomi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-175394.

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The purpose of this study is to investigate how much of the estimated annual electric energy production from Swedish wind power that actually was produced, as well as the history of this agreement over time. The aim is to also examine if there are properties that have caused some group of wind power plants to produce more or less, compared to their estimated production. Operational data on wind turbines collected by the Swedish Energy Agency was analyzed. A survey was made among owners of wind power plants with a nominal power of at least 2 MW. Two different methods for normal year correction

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Pedersen, Shelsea A. (Shelsea Anne). "Paleomagnetism of Lonar impact glass." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/114356.

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Thesis: S.B., Massachusetts Institute of Technology, Department of Earth, Atmospheric, and Planetary Sciences, 2008.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 65-68).<br>Several dozen impact glasses from Lonar Crater, in Maharashtra, India, were analyzed for evidence of impact-generated paleofields, and possible motional remanent magnetization. Lonar Crater formed when a meteorite impacted a bed of Deccan Trap basalts. Upon impact, the basalt was super heated into a fluid melt that would have been ejected from the crater, moving at speeds that allow

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48

Papegaey, Anthony. "Dégénérescences lobaires frontotemporales : vers une nouvelle classification, vers de nouveaux marqueurs." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S048/document.

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Le terme dégénérescence lobaire frontotemporale ou FTLD définit un groupe hétérogène de maladies neurodégénératives caractérisé par des troubles du langage, du comportement et/ou moteurs qui résultent principalement d’une dégénérescence du cortex frontal et temporal. Cette hétérogénéité tant au niveau clinique, génétique que neuropathologique rend cette pathologie très complexe et il existe aujourd’hui un véritable problème de diagnostic différentiel des FTLD. Le diagnostic final des FTLD repose ainsi sur l’examen neuropathologique, la nature des lésions observées et leurs constituants molécul

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Lozar, Hilary Rae. "Including parents in classroom science nights." Montana State University, 2012. http://etd.lib.montana.edu/etd/2012/lozar/LozarH0812.pdf.

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The purpose of this study was to engage parents within the classroom in order to minimize any discomfort parents feel when at or communicating with the school and staff. In order to do this, parents were invited to attend monthly classroom science nights with their families. Each night, a science expert presented to the families and followed the presentation up with some sort of hands-on learning experience. Parents as well as children were encouraged to participate in this treatment, and the resulting environment was informal. As more parents began to participate and word began to spread, I w

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Hawbaker, Jeremy. "The pronominal clitics of Logar Ormuri." Thesis, The University of North Dakota, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1567057.

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<p> This thesis presents a description of the system of pronominal clitics in the Logar dialect of Ormuri, an Iranian language of Afghanistan and Pakistan. The Logar dialect is based in the Logar province of Afghanistan and is near to extinction. The thesis studies grammatical constraints on the occurrence of pronominal clitics in Ormuri sentences. It also investigates discourse factors that influence when a pronominal clitic is used to refer to an entity in the situation that is being talked about, rather than a noun, an independent pronoun, or zero anaphora. My analysis is based on a corpus

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