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Artykuły w czasopismach na temat „Lornoxicam”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Drais, Hayder Kadhim. "Transdermal Delivery of Lornoxicam Hybrid Nanogel: Design, Preparation, Characterization, and In-Vitro Diffusion Evaluation." Iraqi Journal of Industrial Research 10, no. 2 (2023): 98–104. http://dx.doi.org/10.53523/ijoirvol10i2id289.

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Lornoxicam was practically water insoluble and a nonsteroidal anti-inflammatory therapeutic agent thus associated with gastrointestinal tract (GIT) side effects. Lipid polymer hybrid nanocarriers (LPHNs)-based transdermal nanogel of lornoxicam was formulated to increase solubility of lornoxicam and sustained lornoxicam release that lead to eliminate GIT related side effect, prolong therapeutic activity and improve patient compliance .The lornoxicam LPHNs formulations (LH1-LH6) were prepared by microwaves based method. The conventional gel of lornoxicam (G) was prepared by solvent diffusion met

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2

Hussen, Jamal, Mahmoud Kandeel, Turke Shawaf, Abdullah I. A. Al-Mubarak, Naser A. Al-Humam, and Faisal Almathen. "Immunomodulatory Effects of the Cyclooxygenase Inhibitor Lornoxicam on Phenotype and Function of Camel Blood Leukocytes." Animals 11, no. 7 (2021): 2023. http://dx.doi.org/10.3390/ani11072023.

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(1) Background: Lornoxicam is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antiphlogistic and antipyretic effects. The improved tolerance of lornoxicam due to the relatively shorter elimination half-life in comparison to other members of the oxicams may favor its application in the management of pain and inflammation in race dromedary camels. There are no studies conducted yet on the immunomodulatory or immunotoxilogic effect of lornoxicam in camels. Therefore, the current study aimed to evaluate the immunomodulatory effects of the cyclooxygenase inhibitor lornoxicam on some p

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&NA;. "Lornoxicam." Reactions Weekly &NA;, no. 1179 (2007): 22–23. http://dx.doi.org/10.2165/00128415-200711790-00067.

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Balfour, Julia A., Andrew Fitton, and Lee B. Barradell. "Lornoxicam." Drugs 51, no. 4 (1996): 639–57. http://dx.doi.org/10.2165/00003495-199651040-00008.

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Saračević, Amela, and Fahir Bečić. "The synergistic antinociceptive effect of lornoxicam in combination with tramadol." Journal of Health Sciences 3, no. 3 (2013): 238–42. http://dx.doi.org/10.17532/jhsci.2013.114.

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Introduction: One of the most important priorities in therapy is pain control. Therefore, many different groups of drugs are being used for this purpose, primarily opioid analgesics and non-steroidal anti-inflammatory drugs (NSAIDs). Opioid analgesic tramadol, by binding to specific receptors, modulates the perception and response to painful stimuli and inhibits transmitting and further processing of pain impulses. Lornoxicam, which belongs to the oxicam class of NSAIDs, is a non-selective cyclooxygenase inhibitor with strong analgesic and anti-inflammatory effects, and better tolerance profil

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Abraham, Sindhu, Rajamanickam Deveswaran, Sharon Furtado, Srinivasan Bharath, and Varadharajan Madhavan. "Application of Hydrotropic Solubilization in Spectrophotometric Estimation of Lornoxicam from Tablets." International Scholarly Research Notices 2014 (October 29, 2014): 1–4. http://dx.doi.org/10.1155/2014/810128.

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Lornoxicam is a selective cyclooxygenase-1 and cyclooxygenase-2 inhibitor that exhibits anti-inflammatory, analgesic, and antipyretic activities. It is used in osteoarthritis and rheumatoid arthritis; and in treatment of postoperative pain and primary dysmenorrhoea. Lornoxicam is completely insoluble in water but soluble in alkaline solutions. Hydrotropic solubilization is a technique used to increase the aqueous solubility of poorly water-soluble drugs and the present study was aimed at developing a hydrotropic technique to increase the solubility of lornoxicam, using 2 M sodium benzoate as t

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7

Patel, Tushar H., Umang H. Shah, Manan A. Raval, and Samir G. Patel. "DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF LORNOXICAM AND TOLPERISONE HYDROCHLORIDE IN BULK DRUG AND COMBINED DOSAGE FORM." Indian Drugs 59, no. 03 (2022): 47–53. http://dx.doi.org/10.53879/id.59.03.12032.

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A Reverse Phase High Performance Liquid Chromatographic method was developed and validated for the simultaneous estimation of lornoxicam and tolperisone hydrochloride in bulk drug and its combined dosage form. Chromatographic separation was carried out isocratically by reverse phase water enable C18 column (250 mm × 4.6 mm, 5.0 μ) using methanol: acetonitrile: water in ratio of 60:30:10 (V/V/V, pH adjusted to 3.0 with orthophosphoric acid) as a mobile phase at a flow rate of 1 mg min-1 and UV visible detection at wavelength of 285 nm. The retention times for tolperisone hydrochloride and lorno

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El-Bahr, Sabry M., Rabab R. Elzoghby, Mohammed A. Alfattah, Mahmoud Kandeel, and Ahlam F. Hamouda. "Aqueous Ginger (Zingiber officinale) Extract Ameliorates the Harmful Effects of High-Dose Lornoxicam in Albino Male Rats." BioMed Research International 2022 (August 2, 2022): 1–15. http://dx.doi.org/10.1155/2022/1546734.

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Lornoxicam is a potent oxicam-class nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, and antipyretic effects. Its impacts on many biological functions are not fully understood. We measured various biomarkers in male albino rats provided an oral aqueous ginger extract before IM administration of therapeutic and 2× the therapeutic doses of lornoxicam. The aqueous ginger plant extract was characterized by mass spectroscopy, and its effects were determined by examining free radical scavenging activity, blood parameters, renal and hepatic function, semen quality, proin

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9

Puranik, Manisha P., Debarshi Kar Mahapatra, Rajendra O. Ganjiwale, and Shital D. Tiple. "Development and Validation of FTIR Spectroscopic Method for the Quantitative Estimation of Lornoxicam in Tablet Dosage Form." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1633–37. http://dx.doi.org/10.25258/ijpqa.15.3.81.

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Lornoxicam is available in the market as a solid dosage form, particularly tablets. Liquid chromatography has been the recommended assay procedure for lornoxicam in various pharmacopeias. While going through the literature, it was observed that for the analysis of lornoxicam, no FTIR based method was found. The present study involves the development of a novel, rapid, superior, labor-free, non-destructive, and economic FTIR-based analytical technique for the analysis of lornoxicam in both bulk and tablet formulations. International Council validated the method for Harmonization of Technical Re

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10

Bansal, Abanesh kumar, and Vishal Pande. "Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis." Journal of Pharmaceutics 2013 (December 18, 2013): 1–8. http://dx.doi.org/10.1155/2013/906178.

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In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5–8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross

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11

Berk, Barkin. "Effects of Nonsteroidal Anti-inflammatory Drugs on Chondrogenic Differentiation." Journal of Drug Delivery and Therapeutics 14, no. 9 (2024): 60–65. http://dx.doi.org/10.22270/jddt.v14i9.6781.

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BACKROUND: NSAIDs represent a large class of drugs used for their analgesic and anti-inflammatory effects. Background Nevertheless, their effects on chondrogenic differentiation are not known. The present study examines the potential effects of five different NSAIDs, namely Etodolac, Dexketoprofen, Acetaminophen (Paracetamol), Lornoxicam and Ibuprofen on cell viability as well as chondrogenic differentiation using a mouse embryonic ATDC5-cell-derived chondrocyte model. METHODS: ATDC5 cells were treated with different concentrations of the NSAIDs. The viablility was evaluated by MTT assay while

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12

Sapolya, MD, Ozgur, Beyhan Karamanlhoglu, MD, and Dilek Memis, MD. "Analgesic effects of lornoxicam after total abdominal hysterectomy." Journal of Opioid Management 3, no. 3 (2007): 155. http://dx.doi.org/10.5055/jom.2007.0053.

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The authors investigated, in a randomized, placebocontrolled, double-blinded study, the efficacy and safety of lornoxicam on pain after abdominal hysterectomy and on tramadol consumption in patients. Fifty patients were randomized to receive either oral placebo or lornoxicam 8 mg one hour before surgery. Anesthesia was induced with propofol and maintained with sevoflurane in 50 percent N2O/O2 with a fresh gas flow of 2 L/min (50percent N2O in O) and fentanyl (2 fig/kg). All patients received patient-controlled analgesia with tramadol with loading dose of 50 mg; incremental dose of 20 mg; lock

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13

Drakopoulou, Stamatoula, Elissaios Kontis, Eirini Pantiora, et al. "Effects of Lornoxicam on Anastomotic Healing: A Randomized, Blinded, Placebo-Control Experimental Study." Surgery Research and Practice 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/4328089.

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Introduction and Aim. With the implementation of multimodal analgesia regimens, Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are often administered for optimal pain control and reduction of opioid use. The aim of the study was to examine the effects of lornoxicam, a NSAID, on anastomotic healing employing an animal model.Materials and Methods. A total of 28 Wistar rats were randomly assigned in two groups. All animals underwent ascending colonic transection followed by an end-to-end hand sewn anastomosis. Group 1 received intraperitoneally lornoxicam before and daily after surgery. Group 2 re

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14

El-Mahmoudy, Abubakr. "Pharmacokinetics of Lornoxicam in rabbits after single intravenous bolus and intramuscular administrations." International Journal of Pharmacology and Toxicology 4, no. 1 (2016): 66. http://dx.doi.org/10.14419/ijpt.v4i1.5998.

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The pharmacokinetics of lornoxicam (a non-steroidal anti-inflammatory drug) at a dose of 0.4 mg/Kg body weight was evaluated after single intravenous (i.v.) and intramuscular (i.m.) bolus administrations in rabbits. An HPLC assay using pure lornoxicam base as a standard was used to measure its concentrations in plasma at prefixed time points up to 12 hours post administration. Following an i.v. bolus injection, the plasma concentration-time curves of lornoxicam were best represented by two-compartment open model. The drug was rapidly distributed and moderately eliminated with half-lives of dis

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15

Ansari, K. Kareemuddin, and Neeraj Sharma. "Formulation and evaluation of orodispersible tablets of lornoxicam." Journal of Drug Delivery and Therapeutics 8, no. 6 (2018): 225–28. http://dx.doi.org/10.22270/jddt.v8i6.2058.

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Orodispersible tablets (ODTs), also known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water. The purpose of this investigation was to develop mouth dissolving tablets of Lornoxicam using KYRON T-314 (Polacrillin Potassium) as a novel superdisintegrant. Mouth dissolving tablets of lornoxicam were prepared by wet granulation technique using KYRON T-314 as superdisintegrant and menthol as subliming agent. The present study demonstrated potentials for rapid absorption, improved bioavailability, ef

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16

Vijaya Sri, K., D. Sandhya, M. Manchala, and R. S. Dashamukhi. "BOX–BEHNKEN METHOD TO OPTIMIZE LORNOXICAM PRONIOSOMES: PREPARATION, IN VITRO CHARACTERIZATION AND ANALGESIC ACTIVITY." INDIAN DRUGS 55, no. 06 (2018): 21–33. http://dx.doi.org/10.53879/id.55.06.10289.

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The objective of present investigation was to develop and evaluation of proniosomes as the carrier of lornoxicam for topical delivery. lornoxicam-loaded proniosomes were prepared by coacervation phase separation method. The Box–Behnken design used in this study helped in identifying the factors affecting drug entrapment efficiency and drug diffusion. Proniosomes were evaluated for appearance, pH, viscosity, entrapment efficiency and in vitro drug diffusion studies. The optimized formulations were further evaluated to vesicle size, shape, zeta potential, percutaneous permeation and analgesic ef

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17

Jain, Pritam, Miketa Patel, Amar Chaudhari, and Sanjay Surana. "RP-HPLC assay method development for Paracetamol and Lornoxicam in combination and characterization of oxidative degradation products of Lornoxicam." Chemical Industry and Chemical Engineering Quarterly 19, no. 4 (2013): 471–84. http://dx.doi.org/10.2298/ciceq120404084j.

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A simple, specific, accurate and precise reverse phase high pressure liquid chromatographic method has been developed for the simultaneous determination of Paracetamol and Lornoxicam from tablets and to characterize degradation products of Lornoxicam by reverse phase C18 column (Inertsil ODS 3V C-18, 250 x 4.6 mm, 5 ?). The sample was analyzed using Buffer (0.02504 Molar): Methanol in the ratio of 45:55, as a mobile phase at a flow rate of 1.5 mL/min and detection at 290 nm. The retention time for Paracetamol and Lornoxicam was found to be 2.45 and 9.40 min respectively. The method can be used

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S Jafer, Riyam, and Hanan J Kassab. "Development and Characterization of Lornoxicam-Infused Ocular Gel for Effective Treatment of Ocular Inflammation in Domestic Cats." Iraqi Journal of Veterinary Medicine 1, no. 1 (2025): 8–15. https://doi.org/10.30539/pw6vsy73.

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Lornoxicam (LOX) is a non-steroidal anti-inflammatory drug (NSAID) effective in managing ocular inflammation. Traditional delivery methods like liquid drops are cleared rapidly and may not provide sustained therapeutic levels, necessitating the development of an ocular gel formulation. Mucoadhesive polymers such as hyaluronic acid (HA), hydroxypropyl methylcellulose (HPMC), and Carbopol have been identified as suitable excipients to modify drug release profiles. This study aims to formulate an effective ophthalmic 0.1% w/w lornoxicam gel administered to pets for topical and continuous drug rel

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19

Navin, Kishore, Prakash Chandra Shashi, Kumar Navin, and Singh Asha. "An Evaluation of the Effectiveness and Safety of Diclofenac and Lornoxicam as Postoperative Analgesics following Mastoidectomy Surgery." International Journal of Pharmaceutical and Clinical Research 15, no. 4 (2023): 1425–34. https://doi.org/10.5281/zenodo.12681291.

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<strong>Background:</strong> Postoperative discomfort is brought on by the surgical trauma that occurs during the manipulation of tissues. Lornoxicam is a nonselective NSAID with analgesic and anti-inflammatory properties. It acts more quickly than other oxicams and has a shorter half-life. Diclofenac sodium, a cyclooxygenase inhibitor, has long been used to manage postoperative pain. The active metabolite of the drug accumulates in the inflamed tissue and maintains a greater plasma concentration for several hours by acting as an analgesic. The current study compares the effectiveness and

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Isola, Gaetano, Angela Alibrandi, Eugenio Pedullà, et al. "Analysis of the Effectiveness of Lornoxicam and Flurbiprofen on Management of Pain and Sequelae Following Third Molar Surgery: A Randomized, Controlled, Clinical Trial." Journal of Clinical Medicine 8, no. 3 (2019): 325. http://dx.doi.org/10.3390/jcm8030325.

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The aim of this study was to analyze the effectiveness of Lornoxicam and Flurbiprofen in reducing perioperative sequelae after impacted mandibular third molar surgery. Ninety-one patients who needed surgical extraction of an impacted mandibular third molar were selected for the study. All subjects were randomly allocated to receive one of the following treatments twice a day for 5 days after surgery: placebo (n = 29), Flurbiprofen (n = 31), or Lornoxicam (n = 31). The primary outcome was postoperative pain, evaluated using the visual analogue scale (VAS) score at 30 min, 2, 6, 12, 24, 48 h, 7

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Nalini, R., and J. Ezhilramya. "A COMPARATIVE STUDY OF EFFICACY AND SAFETY OF LORNOXICAM AND DICLOFENAC AS POSTOPERATIVE ANALGESICS AFTER MASTOIDECTOMY SURGERY." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 2 (2017): 77. http://dx.doi.org/10.22159/ijpps.2017v9i2.15091.

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<p><strong>Objective</strong>:<strong> </strong>The objective of the research was to evaluate the efficacy and safety of lornoxicam compared to diclofenac in the management of postoperative pain following mastoidectomy surgery.<strong> </strong></p><p><strong>Methods: </strong>The present study was a<strong> </strong>prospective, single-blinded, randomised study. 80 mastoidectomy patients were randomised into two groups. Group A received lornoxicam 8 mg and group B received diclofenac 75 mg intramuscularly twice dail

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Romanenko, V. I. "Evaluation of analgetic properties of etoricoxib and lornoxicam and their effect on central sensitization in chronic low back pain." PAIN, JOINTS, SPINE 12, no. 1 (2022): 30–39. http://dx.doi.org/10.22141/pjs.12.1.2022.326.

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Introduction. Chronic low back pain is a serious health problem in the world. The phenomena of peripheral and central sensitization play an important role in the transition of acute pain to chronic, as well as in the maintenance of chronic pain. One of the descending inhibitory mechanisms that modulates the perception of pain is conditioned pain modulation. Activation of this mechanism reduces neuronal activity at the level of the dorsal horn of the spinal cord, which leads to a decrease in pain and inhibition of hyperalgesia. For pathogenetic therapy of chronic low back pain drugs from the gr

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Kodalkar, Swapnil J., Rohan A. Khutale, Sachin S. Salunkhe, Sachin S. Mali, and Sameer J. Nadaf. "Implementation of time release technology in formulation development and evaluation of sustained release tablet of Lornoxicam." Indian Journal of Pharmaceutical and Biological Research 2, no. 01 (2014): 68–75. http://dx.doi.org/10.30750/ijpbr.2.1.11.

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In present study, the attempts have been made to formulate sustained release tablets of lornoxicam by direct compression method. Based on viscosity grades different proportions of hydrophilic polymers (HPMC K4M, HPMC K15M, HPMC K100M) are used for preparation of lornoxicam sustained release matrix tablet. The drug excipient mixtures were subjected to preformulation studies comprising of micromeritic properties. The tablets were subjected to various studies like as physicochemical studies, in vitro drug release, kinetic studies, etc. FTIR studies shown there was no interaction between drug and

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Dr., D. Satyavati 1. *. K. Shanthi 1. B. Madhavi Latha 1. Dr. A. Madhukar 2. "VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF LORNOXICAM AND THIOCOLCHICOSIDE IN BULK AND TABLET DOSAGE FORM." Journal of Scientific Research in Pharmacy 7, no. 3 (2018): 24–29. https://doi.org/10.5281/zenodo.1203673.

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<strong><em>ABSTRACT</em></strong> <strong><em>A</em></strong><em> rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of </em><em>Thiocolchicoside and Lornoxicam</em><em>, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Altima C18 (4.6 x 150mm, 5µm) column using a mixture of Methanol and water (5:95% v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 285nm. The retention time of the </em><em>Thiocolchicoside and Lornoxicam</em><em> was </em><em>2.088

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Majeed, Israa A., and Nada N. Al-Shawi. "Effects of Omega-3 Co-Administered with Therapeutic Dose of lornoxicam on Male Rats' Liver." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 28, no. 2 (2019): 159–64. http://dx.doi.org/10.31351/vol28iss2pp159-164.

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The purpose of this study was to investigate the effect of omega-3 poly unsaturated fatty-acids co-administered with the therapeutic dose of lornoxicam on liver of healthy rats. Twenty-eight adults male rats weighing 180-200g were used in this study and the animals were randomly divided into four groups of seven rats each. Group I: negative control/rats intraperitoneally injected with normal saline in a dose 5ml/kg/day; Group II: rats intraperitoneally injected with lornoxicam at dose 0.7 mg/kg/day; Group III: rats orally-administered omega-3 only at a dose 185mg/kg/day; Group IV: rats co-admi

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Marella, Vijaya Lakshmi, and Chaitanya S. N. "RP-HPLC METHOD FOR ESTIMATION OF LORNOXICAM IN TABLETS AND IN DISSOLUTION SAMPLES USING MASS SPECTROMETRIC COMPATIBLE BUFFERS." INDIAN DRUGS 58, no. 07 (2021): 32–37. http://dx.doi.org/10.53879/id.58.07.12068.

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A selective and sensitive reverse phase High Performance Liquid Chromatographic method has been developed and validated for the estimation of lornoxicam in bulk, pharmaceutical dosage forms and in dissolution samples. The analysis was performed isocratically on an Inertsil column (250* 4.6 mm, 5 µm) using a mass spectrometric compatible mobile phase of 10 mM ammonium acetate: acetonitrile (50:50 V/V) at a flow rate of 1 mL/min.The detection wavelength was 290 nm. The retention time was found to be 4.573 min for lornoxicam. The linearity of the method has been satisfied with Beer Lambert’s law

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Cakmak, Biricik Melis, Gokhan Cakmak, Elif Akpek, Gulnaz Arslan, and Mehmet Sukru Sahin. "Peri- and Postanalgesic Properties of Lidokain, Lornoxicam, and Nitroglycerine Combination at Intravenous Regional Anesthesia." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/737109.

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Background.This study was conducted to compare and evaluate the effect of adding lornoxicam or nitroglycerine as adjuncts to lidocaine in intravenous regional anesthesia (IVRA).Methods.60 patients were randomly separated into three groups, lidocaine group (group L), lidocaine + lornoxicam group (group LL), and lidocaine + lornoxicam + transdermal nitroglycerine group (group LL-N). Hemodynamic parameters, sensory and motor blocks onset, and recovery times were recorded. Analgesic consumption for tourniquet pain and postoperative period were recorded.Results.Sensory block onset times and motor b

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Skjodt, Neil M., and Neal M. Davies. "Clinical Pharmacokinetics of Lornoxicam." Clinical Pharmacokinetics 34, no. 6 (1998): 421–28. http://dx.doi.org/10.2165/00003088-199834060-00001.

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&NA;. "Lornoxicam relieves postoperative pain." Inpharma Weekly &NA;, no. 1022 (1996): 12. http://dx.doi.org/10.2165/00128413-199610220-00018.

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Canduz, Basak, Huseyin Aktug, Ömür Mavioğlu, et al. "Epidural lornoxicam administration – innocent." Journal of Clinical Neuroscience 14, no. 10 (2007): 968–74. http://dx.doi.org/10.1016/j.jocn.2006.10.006.

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Trampitsch, E., W. Pipam, M. Moertl, et al. "Lornoxicam bei gynäkologischen Eingriffen." Der Schmerz 17, no. 1 (2003): 4–10. http://dx.doi.org/10.1007/s00482-001-0129-7.

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Aktug, H., B. Candüz, Ö. Mavioğlu, et al. "Epidural Lornoxicam Administration- Innocent." Regional Anesthesia and Pain Medicine 33, Sup 1 (2008): e40. http://dx.doi.org/10.1097/00115550-200809001-00072.

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Dineshmohan, S., V. R. M. Gupta, A. Ramesh, V. Harika, and T. Sravani. "Effect of HPMC and ethyl cellulose polymeric granules and its combinations in press coated tablets of lornoxicam: fabrication and in vitro characterization." International Current Pharmaceutical Journal 4, no. 10 (2015): 447–52. http://dx.doi.org/10.3329/icpj.v4i10.24914.

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The main objective of the present exploration was to formulate and evaluate chronomodulated press-coated tablets to deliver the NSAID lornoxicam, when a pain in the joints, functional disability persist in the early morning time is typically observed in most Rheumatoid arthritis (RA) patients. Pre formulation studies and drug excipient compatibility studies were carried out for lornoxicam and excipients. Core tablets containing lornoxicam was prepared by direct compression method and the tablets were subjected to various pre-compression and post-compression parameters (C1-C4 formula) based on

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JATAV, MAHENDRA PRASAD. "Formulation and Evaluation of Lecithin Organogel for Treatment of Arthritis." International Journal of Advances in Scientific Research 1, no. 7 (2015): 300. http://dx.doi.org/10.7439/ijasr.v1i7.2251.

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AbstractArthritis is a disease of the joint that involves inflammation of one or more joints. The common symptoms of arthritis disorders include varied levels of pain, swelling, joint stiffness, and sometimes a constant ache around the joints. More than 20 million individuals with arthritis have severe limitations in function on a daily basis. The objective of this study was to resolve conventional dosage forms of NSAIDs, which are at increased risk for serious gastrointestinal complications, when administered through oral route. Topical administration of NSAIDs could deliver lornoxicam to the

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Hadi, Mohd Abdul, NG Raghavendra Rao, and A. Srinivasa Rao. "Formulation and evaluation of compression Coated tablets of Lornoxicam for Targeting early morning peak symptoms of Rheumatoid arthritis." Dhaka University Journal of Pharmaceutical Sciences 12, no. 2 (2014): 109–17. http://dx.doi.org/10.3329/dujps.v12i2.17620.

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In the present research work, we have designed a pulsatile formulation of lornoxicam to treat rheumatoid arthritis as per the chronotherapeutic pattern of the disease. Core tablets were prepared by incorporating different concentration of disintegrants and were compressed in between different concentration and combination of hydrophobic and hydrophilic polymers. The core and compression coated tablets were subjected to pre-formulation, physicochemical, in-vitro drug release and stability studies. FTIR and DSC studies revealed that there was not any chemical reaction between pure drug lornoxica

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Rana, M., S. Durgapal, A. Rana Joshi, and R. K. Vidyarthi. "FORMULATION AND EVALUATION OF MICROPARTICULATED GEL DRUG DELIVERY SYSTEM OF LORNOXICAM FOR THE EFFECTIVE TREATMENT OF RHEUMATOID ARTHRITIS." INDIAN DRUGS 54, no. 05 (2017): 63–66. http://dx.doi.org/10.53879/id.54.05.10810.

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Aim of the study was formulation and evaluation of microparticles loaded transdermal gel of lornoxicam. Gel was prepared by incorporating microparticles into gel base of HPMC K15M. Lornoxicam was loaded in microparticles by emulsion-solvent evaporation method using polymers ethylcellulose and Eudragit RS100 in various ratio. The microparticles were evaluated for particle size, shape, entrapment efficiency, compatibility studies and drug content. Further, the prepared gels were evaluated for viscosity, spreadability, pH, dug content in vitro drug diffusion studies. Result showed that microparti

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Thombre, Nilima A., Pooja S. Niphade, Eknath D. Ahire, and Sanjay J. Kshirsagar. "Formulation Development and Evaluation of Microemulsion Based Lornoxicam Gel." Biosciences Biotechnology Research Asia 19, no. 1 (2022): 69–80. http://dx.doi.org/10.13005/bbra/2968.

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The objective of the existing research was formulation development and preparation of microemulsion loaded emulgel in augmenting the topical delivery of Lornoxicam. Emulsion and gel combined are recognized as Emulgels. Gelling agents Carbopol 940, 974, 980 were used to formulating Lornoxicam emulgel. The drug release from emulgel was determined depending on the different gelling agents. Clove oil for internal phase and Polyethylene glycol 200 was applied as co-surfactant and Tween 20 as permeation enhancer. Prepared emulgels were evaluated for in-vitro and in- vivo anti-inflammatory activity u

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Sarkhil, Mohammed Ziauddin, Hemant Kumar Dutt, and Rajaram S. "A prospective study of lornoxicam as pre-emptive analgesic in abdominal surgeries in tertiary care hospital in Salem, India." International Journal of Basic & Clinical Pharmacology 6, no. 7 (2017): 1778. http://dx.doi.org/10.18203/2319-2003.ijbcp20172748.

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Background: Preemptive analgesia, involves the introduction of an analgesic regimen before the onset of noxious stimuli, with the goal of preventing sensitization of the nervous system to subsequent stimuli that could amplify pain.Methods: To determine the efficacy and safety of Lornoxicam when administered preemptively by using Wong-Baker FACES Pain Rating scale. The patients undergoing abdominal surgery were randomly categorized into group A and B of 25 each. Group A- Received Lornoxicam 8mg (1ml) one hour before surgery. Group B- Not received any analgesic before surgery. Primary measuremen

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Shabaraya, A. R., G. Sumana, and K. Vineetha. "Formulation and Evaluation of Nanosponges-loaded Gel of Lornoxicam for Topical Delivery." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 02 (2022): 634–39. http://dx.doi.org/10.25258/ijddt.12.2.29.

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Nanosponge loaded gels are novel drug delivery system that combine the advantages of achieving optimum concentration of drug at site of action and reduction in systemic side effects. The objective of the present study was to formulate and evaluate gel loaded with nanosponges of Lornoxicam for topical delivery. Lornoxicam nanosponges were prepared successfully using ethyl cellulose as polymer, polyvinyl alcohol as cross-linking agent and dichloromethane as solvent by emulsion solvent diffusion method, which undergo analysis of drug entrapment efficiency, surface morphology, particle size analys

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Vertkin, A. L., G. R. Tabeeva, M. L. Kukushkin, et al. "Interdisciplinary Expert Consultation for Effective and Safe Anesthesia in Internal Disease Symptomatology." RMJ, no. 3 (2025): 56–62. https://doi.org/10.32364/2225-2282-2025-3-11.

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On December 17, 2024, an Interdisciplinary Expert Consultation for Effective and Safe Anesthesia in Internal Disease Symptomatology was held in Moscow. Leading experts in therapy, clinical pharmacology, neurology, rheumatology, traumatology and orthopedics, oncology, gynecology and urology were involved. The aim of the Interdisciplinary Expert Consultation was to determine a role and place of advanced NSAIDs (in particular, lornoxicam [Xefokam]) in pain management (regardless of a condition). The experts discussed the up-to-date evidence base and a NSAID’s position in current clinical guidelin

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Aarti, Nimse* Dr. Sachin Kale Dr. K. R. Biyani. "Formulation And In-Vitro Testing of Quick Dissolving Tablets of Nsaids Drug Along with Musa Paradisiaca Powder." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3468–73. https://doi.org/10.5281/zenodo.15475438.

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Lornoxicam is a non-steroidal anti-inflammatory medication commonly used as an anti-inflammatory, analgesic and antipyretic agent.  Conventional solid dosage forms are frequently linked to a faster disintegration time, but oral bioavailability is poor, with only 50% of the dose reaching systemic circulation due to substantial first pass metabolism.  Because the banana powder in the fast-dissolving tablets dissolves quickly, the medication is released right away. Two to four hours is the elimination half-life.  For patients at high risk of developing NSAID-induced stomach and duo

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Jin, Juying, Su Min, Qibin Chen, and Dong Zhang. "Patient-Controlled Intravenous Analgesia With Tramadol and Lornoxicam After Thoracotomy: A Comparison With Patient-Controlled Epidural Analgesia." International Surgery 106, no. 2 (2022): 75–81. http://dx.doi.org/10.9738/intsurg-d-16-00252.1.

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Objective To determine efficacy and safety of patient-controlled intravenous analgesia (PCIA) with tramadol and lornoxicam for postoperative analgesia, and its effects on surgical outcomes in patients after thoracotomy. Summary of background data Adequate pain relief after thoracic surgery is of particular importance, not only for keeping patients comfortable but also for reducing the incidence of postoperative complications. PCIA with tramadol and lornoxicam could be an acceptable alternative to patient-controlled epidural analgesia (PCEA) for pain management after thoracotomy. Methods The re

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&NA;. "Lornoxicam reduces phenprocoumon anticoagulation time." Inpharma Weekly &NA;, no. 1175 (1999): 20. http://dx.doi.org/10.2165/00128413-199911750-00036.

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Aktug, H., B. Candüz, Ö. Mavioğlu, et al. "121. Epidural Lornoxicam Administration- Innocent." Regional Anesthesia & Pain Medicine 33, Suppl 1 (2008): e40.1-e40. http://dx.doi.org/10.1136/rapm-00115550-200809001-00072.

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AKTUG, H., B. CANDUZ, O. MAVIOGLU, et al. "121: Epidural Lornoxicam Administration- Innocent." Regional Anesthesia and Pain Medicine 33, no. 5 (2008): e40-e40. http://dx.doi.org/10.1016/j.rapm.2008.07.083.

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Dittrich, P., S. Radhofer-Welte, S. Mayerhofer, W. R. Kukovetz, and H. P. Ferber. "Comparative pharmacokinetics of parenteral lornoxicam." European Journal of Pharmacology 183, no. 6 (1990): 2265–66. http://dx.doi.org/10.1016/0014-2999(90)93808-4.

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Prasad, Ayya Rajendra, and Bannaravuri Thireesha. "UV-SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF LORNOXICAM IN MICROSPONGES." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 74. http://dx.doi.org/10.22159/ijap.2018v10i1.22357.

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Objective: To develop and validate a novel, specific, precise and simple UV-spectrophotometric method for the estimation of lornoxicam present in microsponges.Methods: UV-spectrophotometric determination was performed with Thermo Scientific Evolution 201 UV-Vis spectrophotometer using methanol as a medium. The spectrum of the standard solution was run from 200-400 nm range for the determination of absorption maximum (λ max). λ max of lornoxicam was found at 353 nm. The absorbance of standard solutions of 3, 6, 9, 12 and 15, µg/ml of drug solution was measured at an absorption maximum at 353 nm

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Shafiq, Muhammad, Barkat Ali Khan, Sheikh Abdur Rashid, et al. "Biodegradable Polymeric Pharmaceutical Nanoemulgel Coloaded with Eucalyptol-Lornoxicam: Fabrication and Characterizations for Possible Better Pain Management." BioMed Research International 2023 (May 13, 2023): 1–16. http://dx.doi.org/10.1155/2023/4227242.

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Nanoemulgels are considered as potential and ideal drug delivery systems for the transdermal administration of poorly soluble drugs like lornoxicam. Their intrinsic characteristics, such as small globule size as well as excipient type, make transdermal passage of the drug easier. The current study was aimed at developing nanoemulgel based formulation of lornoxicam coloaded with eucalyptol to enhance drug skin permeation and bioavailability in order to promote therapeutic outcome in appropriate time. High shear homogenization technique was utilized to develop optimized lornoxicam encapsulated n

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Dr., Gampa Vijay Kumar and M.Bala Vidya Sagar. "A STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF LORNOXICAM, PARACETMOL AND SERRATIOPEPTIDASE IN COMBINED FORMULATION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 12 (2018): 16557–75. https://doi.org/10.5281/zenodo.2429537.

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<em>For routine analytical purpose it is desirable to establish methods capable of analyzing huge number of samples in a short time period with good robustness, accuracy and precision without any prior separation step. HPLC method generates large amount of quality data, which serve as highly powerful and convenient analytical tool. Lornoxicam & Paracetamol was freely soluble in water and alcohol . Serratiopeptidase was freely soluble in alcohol and sparingly soluble in water. Methanol and potassium dihydrogen ortho phosphate( pH 3) was chosen as the mobile phase. The run time of the HPLC p

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Thorat, Kiran R., and Ravindra B. Laware. "Formulation and evaluation of Lornoxicam loaded Lyotropic liquid crystalline gel." Journal of Drug Delivery and Therapeutics 9, no. 6 (2019): 116–25. http://dx.doi.org/10.22270/jddt.v9i6.3702.

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GIT irritation is prominent limitation with the use of Non-steroidal anti-inflammatory drugs (NSAID’s). There is rising interest in designing formulations which will deliver the drug at the site of action as topical gels, to avoid GIT irritation and other systemic side effects. Liquid Crystal phase has emerged as a novel material for the preparation of topical drug delivery system. In present study the attempt is made to prepare Lornoxicam loaded lyotropic liquid crystalline gel using glycerol monooleate. Glycerol monooleate is biocompatible, bioadhesive, penetration enhancer and sustain relea

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