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Artykuły w czasopismach na temat „Lp82”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 9 lutego 2022

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1

Ma, H., M. Shih, I. Hata, C. Fukiage, M. Azuma, and T. R. Shearer. "Lp85 calpain is an enzymatically active rodent-specific isozyme of lens Lp82." Current Eye Research 20, no. 3 (January 2000): 183–89. http://dx.doi.org/10.1076/0271-3683(200003)2031-9ft183.

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Fukiage, Chiho, Emi Nakajima, Hong Ma, Mitsuyoshi Azuma, and Thomas R. Shearer. "Characterization and Regulation of Lens-specific Calpain Lp82." Journal of Biological Chemistry 277, no. 23 (March 19, 2002): 20678–85. http://dx.doi.org/10.1074/jbc.m200697200.

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Shearer, T. R., H. Ma, M. Shih, I. Hata, C. Fukiage, Y. Nakamura, and M. Azuma. "Lp82 calpain during rat lens maturation and cataract formation." Current Eye Research 17, no. 11 (January 1998): 1037–43. http://dx.doi.org/10.1076/ceyr.17.11.1037.5232.

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NAKAMURA, Y., C. FUKIAGE, H. MA, M. SHIH, M. AZUMA, and T. R. SHEARER. "Decreased Sensitivity of Lens-Specific Calpain Lp82 to Calpastatin Inhibitor." Experimental Eye Research 69, no. 2 (August 1999): 155–62. http://dx.doi.org/10.1006/exer.1998.0686.

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MA, H., I. HATA, M. SHIH, C. FUKIAGE, Y. NAKAMURA, M. AZUMA, and T. R. SHEARER. "Lp82 is the Dominant Form of Calpain in Young Mouse Lens." Experimental Eye Research 68, no. 4 (April 1999): 447–56. http://dx.doi.org/10.1006/exer.1998.0625.

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Ueda, Yoji, Ashley L. McCormack, Thomas R. Shearer, and Larry L. David. "Purification and Characterization of Lens Specific Calpain (Lp82) from Bovine Lens." Experimental Eye Research 73, no. 5 (November 2001): 625–37. http://dx.doi.org/10.1006/exer.2001.1071.

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Gao, Junyuan, Xiurong Sun, Francisco J. Martinez-Wittinghan, Xiaohua Gong, Thomas W. White, and Richard T. Mathias. "Connections Between Connexins, Calcium, and Cataracts in the Lens." Journal of General Physiology 124, no. 4 (September 27, 2004): 289–300. http://dx.doi.org/10.1085/jgp.200409121.

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There is a good deal of evidence that the lens generates an internal micro circulatory system, which brings metabolites, like glucose, and antioxidants, like ascorbate, into the lens along the extracellular spaces between cells. Calcium also ought to be carried into the lens by this system. If so, the only path for Ca2+ to get out of the lens is to move down its electrochemical gradient into fiber cells, and then move by electrodiffusion from cell to cell through gap junctions to surface cells, where Ca-ATPase activity and Na/Ca exchange can transport it back into the aqueous or vitreous humor

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MA, H., M. SHIH, I. HATA, C. FUKIAGE, M. AZUMA, and T. R. SHEARER. "Protein for Lp82 Calpain Is Expressed and Enzymatically Active in Young Rat Lens." Experimental Eye Research 67, no. 2 (August 1998): 221–29. http://dx.doi.org/10.1006/exer.1998.0515.

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Inomata, Mitsushi, Masami Hayashi, Yoshimasa Ito, Yuko Matsubara, Makoto Takehana, Seiichi Kawashima, and Seigo Shumiya. "Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR)." Current Eye Research 25, no. 4 (January 2002): 207–13. http://dx.doi.org/10.1076/ceyr.25.4.207.13486.

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Azuma, Mitsuyoshi, Yoshiyuki Tamada, Sayaka Kanaami, Emi Nakajima, Yoshikuni Nakamura, Chiho Fukiage, Neil E. Forsberg, Melinda K. Duncan, and Thomas R. Shearer. "Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallins." Biochemical and Biophysical Research Communications 307, no. 3 (August 2003): 558–63. http://dx.doi.org/10.1016/s0006-291x(03)01194-x.

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Ueda, Yoji, Chiho Fukiage, Marjorie Shih, Thomas R. Shearer та Larry L. David. "Mass Measurements of C-terminally Truncated α-Crystallins from Two-dimensional Gels Identify Lp82 as a Major Endopeptidase in Rat Lens". Molecular & Cellular Proteomics 1, № 5 (травень 2002): 357–65. http://dx.doi.org/10.1074/mcp.m200007-mcp200.

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Li, H. Y., H. Osman, C. W. Kang, T. Ba, and J. Lou. "Numerical and experimental studies of water disinfection in UV reactors." Water Science and Technology 80, no. 8 (October 15, 2019): 1456–65. http://dx.doi.org/10.2166/wst.2019.394.

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Abstract Performance of UV reactors for water disinfection is investigated in this paper. Both experimental and numerical studies are performed on base reactor LP24. Enterobacteria phage MS2 is chosen as the challenge microorganism in the experiments. Experiments are conducted to evaluate the effect of different parameters, i.e. flow rate and UV transmission, on the reactor performance. Simulation is carried out based on the commercial software ANSYS FLUENT with user defined functions (UDFs) implemented. The UDF is programmed to calculate UV dose absorbed by different microorganisms along thei

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13

Späth, Gerald F., Lon-Fye Lye, Hiroaki Segawa, Salvatore J. Turco, and Stephen M. Beverley. "Identification of a Compensatory Mutant (lpg2−REV) of Leishmania major Able To Survive as Amastigotes within Macrophages without LPG2-Dependent Glycoconjugates and Its Significance to Virulence and Immunization Strategies." Infection and Immunity 72, no. 6 (June 2004): 3622–27. http://dx.doi.org/10.1128/iai.72.6.3622-3627.2004.

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ABSTRACT Different Leishmania species rely to different extents on abundant glycoconjugates, such as lipophosphoglycan (LPG) and related molecules, in mammalian infections. Previously, we showed that Leishmania major deletion mutants lacking the Golgi GDP-mannose transporter LPG2, which is required for assembly of the dominant phosphoglycan (PG) repeats of LPG, were unable to survive in macrophages. These lpg2 − mutants, however, retained the ability to generate asymptomatic, persistent infections in mice. In contrast, Ilg and colleagues showed that Leishmania mexicana LPG2 mutants retained vi

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Yun, C. Chris, Hong Sun, Dongsheng Wang, Raluca Rusovici, Amanda Castleberry, Randy A. Hall, and Hyunsuk Shim. "LPA2 receptor mediates mitogenic signals in human colon cancer cells." American Journal of Physiology-Cell Physiology 289, no. 1 (July 2005): C2—C11. http://dx.doi.org/10.1152/ajpcell.00610.2004.

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Lysophosphatidic acid (LPA) is a mediator of multiple cellular responses. LPA mediates its effects predominantly through the G protein-coupled receptors LPA1, LPA2, and LPA3. In the present work, we studied LPA2-mediated signaling using human colon cancer cell lines, which predominantly express LPA2. LPA2 activated Akt and Erk1/2 in response to LPA. LPA mediated Akt activation was inhibited by pertussis toxin (PTX), whereas Erk1/2 activation was completely inhibited by a blocker of phospholipase Cβ, U-73122. LPA also induced interleukin-8 (IL-8) synthesis in the colon cancer cells by primarily

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Dulebohn, Daniel P., Aaron Bestor, and Patricia A. Rosa. "Borrelia burgdorferi Linear Plasmid 28-3 Confers a Selective Advantage in an Experimental Mouse-Tick Infection Model." Infection and Immunity 81, no. 8 (June 10, 2013): 2986–96. http://dx.doi.org/10.1128/iai.00219-13.

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ABSTRACTBorrelia burgdorferi, the bacterium that causes Lyme disease, has a unique segmented genome consisting of numerous linear and circular plasmids and a linear chromosome. Many of these genetic elements have been found to encode factors critical forB. burgdorferito complete the infectious cycle. However, several plasmids remain poorly characterized, and their roles during infection withB. burgdorferihave not been elucidated. To more fully characterize the role of one of the four 28-kb linear plasmids, lp28-3, we generated strains specifically lacking lp28-3 and assayed the contribution of

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Labandeira-Rey, Maria, and Jonathan T. Skare. "Decreased Infectivity in Borrelia burgdorferi Strain B31 Is Associated with Loss of Linear Plasmid 25 or 28-1." Infection and Immunity 69, no. 1 (January 1, 2001): 446–55. http://dx.doi.org/10.1128/iai.69.1.446-455.2001.

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ABSTRACT Previous reports indicated a correlation between loss of plasmids and decreased infectivity of Borrelia burgdorferi strain B31, suggesting that plasmids may encode proteins that are required for pathogenesis. In this study, we expand on this correlation. Using theB. burgdorferi genomic sequence, we designed primers specific for each plasmid, and by using PCR we catalogued 11 linear and 2 circular plasmids from 49 clonal isolates of a mid-passage B. burgdorferi strain B31, initially derived from infected mouse skin, and 20 clones obtained from mouse skin infected with a low-passage iso

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Oh, Yong-Seok, Nam Won Jo, Jung Woong Choi, Hyeon Soo Kim, Sang-Won Seo, Kyung-Ok Kang, Jong-Ik Hwang та ін. "NHERF2 Specifically Interacts with LPA2 Receptor and Defines the Specificity and Efficiency of Receptor-Mediated Phospholipase C-β3 Activation". Molecular and Cellular Biology 24, № 11 (1 червня 2004): 5069–79. http://dx.doi.org/10.1128/mcb.24.11.5069-5079.2004.

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ABSTRACT Lysophosphatidic acid (LPA) activates a family of cognate G protein-coupled receptors and is involved in various pathophysiological processes. However, it is not clearly understood how these LPA receptors are specifically coupled to their downstream signaling molecules. This study found that LPA2, but not the other LPA receptor isoforms, specifically interacts with Na+/H+ exchanger regulatory factor2 (NHERF2). In addition, the interaction between them requires the C-terminal PDZ domain-binding motif of LPA2 and the second PDZ domain of NHERF2. Moreover, the stable expression of NHERF2

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Contos, James J. A., Isao Ishii, Nobuyuki Fukushima, Marcy A. Kingsbury, Xiaoqin Ye, Shuji Kawamura, Joan Heller Brown, and Jerold Chun. "Characterization of lpa2 (Edg4) and lpa1/lpa2 (Edg2/Edg4) Lysophosphatidic Acid Receptor Knockout Mice: Signaling Deficits without Obvious Phenotypic Abnormality Attributable to lpa2." Molecular and Cellular Biology 22, no. 19 (October 1, 2002): 6921–29. http://dx.doi.org/10.1128/mcb.22.19.6921-6929.2002.

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ABSTRACT Lysophosphatidic acid (LPA), a bioactive lipid produced by several cell types including postmitotic neurons and activated platelets, is thought to be involved in various biological processes, including brain development. Three cognate G protein-coupled receptors encoded by lpa1 /lp A1/Edg-2/Gpcr26, lpa2 /lp A2/Edg-4, and lpa3 /lp A3/Edg-7 mediate the cellular effects of LPA. We have previously shown that deletion of lpa1 in mice results in craniofacial dysmorphism, semilethality due to defective suckling behavior, and generation of a small fraction of pups with frontal hematoma. To fu

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Labandeira-Rey, Maria, J. Seshu, and Jonathan T. Skare. "The Absence of Linear Plasmid 25 or 28-1 of Borrelia burgdorferi Dramatically Alters the Kinetics of Experimental Infection via Distinct Mechanisms." Infection and Immunity 71, no. 8 (August 2003): 4608–13. http://dx.doi.org/10.1128/iai.71.8.4608-4613.2003.

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ABSTRACT The 25-kb linear plasmid lp25 and one of the 28-kb linear plasmids (lp28-1) are required for experimental infection in Borrelia burgdorferi, the etiologic agent of Lyme disease. The loss of these plasmids either eliminates infectivity (lp25) or significantly increases the 50% infective dose during a 2-week infection period (lp28-1). This study assessed the kinetics of bacterial dissemination in C3H/HeN mice infected with B. burgdorferi lacking either lp25 or lp28-1, as well as their wild-type parent, and tracked the development of specific borrelial antibodies over a 3-week period. Th

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Ab Ghani, Rosmida Binti, Najah Binti Mohd Nawi, and Norhafiza Binti Idris. "Levels Politechnic Community Satisfaction to The Use of Lebuhraya Pantai Timur 2." Jurnal Konseling dan Pendidikan 6, no. 3 (November 30, 2018): 121. http://dx.doi.org/10.29210/128000.

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Construction of East Coast Expressway 2 (LPT2) has a large impact in being able to link the states on the East Coast in a time shorter than existing roads. This gives a more comfortable alternative ride to the local community and beyond. However, there are still complaints from users regarding the facilities and services provided in LPT2. Thus, a study carried out to determine the level of satisfaction of polytechnic communities against the use of LPT2. A total of 222 respondent from four polytechnic involved in this study. Analysis of the findings made by using descriptive statistic and T-tes

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Embers, Monica E., Xavier Alvarez, Tara Ooms, and Mario T. Philipp. "The Failure of Immune Response Evasion by Linear Plasmid 28-1-Deficient Borrelia burgdorferi Is Attributable to Persistent Expression of an Outer Surface Protein." Infection and Immunity 76, no. 9 (July 14, 2008): 3984–91. http://dx.doi.org/10.1128/iai.00387-08.

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ABSTRACT Infectivity and persistence by Borrelia burgdorferi, the etiologic agent of Lyme disease, rely stringently on regulatory events. Among these is the downregulation of lipoprotein antigen expression, exemplified by outer surface protein C (OspC), at the advent of specific immunity in the mammalian host. B. burgdorferi spirochetes that lack the linear plasmid 28-1 (lp28-1) succumb to the host's immune response. We thus explored the notion that these two phenomena were related—that lp28-1− organisms fail to downregulate ospC and thus are cleared following the appearance of anti-OspC antib

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Chen, Min, L. Nicole Towers, and Kathleen L. O'Connor. "LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells." American Journal of Physiology-Cell Physiology 292, no. 5 (May 2007): C1927—C1933. http://dx.doi.org/10.1152/ajpcell.00400.2006.

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Lysophosphatidic acid (LPA) acts via binding to specific G protein-coupled receptors and has been implicated in the biology of breast cancer. Here, we characterize LPA receptor expression patterns in common established breast cancer cell lines and their contribution to breast cancer cell motility. By measuring expression of the LPA receptors LPA1, LPA2, and LPA3 with real-time quantitative PCR, we show that the breast cancer cell lines tested can be clustered into three main groups: cells that predominantly express LPA1 (BT-549, Hs578T, MDA-MB-157, MDA-MB-231, and T47D), cells that predominant

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Lawrenz, Matthew B., R. Mark Wooten, and Steven J. Norris. "Effects of vlsE Complementation on the Infectivity of Borrelia burgdorferi Lacking the Linear Plasmid lp28-1." Infection and Immunity 72, no. 11 (November 2004): 6577–85. http://dx.doi.org/10.1128/iai.72.11.6577-6585.2004.

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ABSTRACT The loss of linear plasmid lp28-1, which contains the vls antigenic variation locus, is associated with reduced infectivity of Borrelia burgdorferi in immunocompetent mice. The recombinant shuttle vector pBBE22, which includes the virulence determinant BBE22 from lp25 and restores infectivity to readily transformable B. burgdorferi lacking lp25 and lp56, was used to determine the effect of trans expression of vlsE on virulence. Spirochetes lacking lp28-1 were complemented with the plasmid pBBE22:vlsE, containing both BBE22 and vlsE. VlsE protein produced by this construct was expresse

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Rinaldi, Mariana Roennau Lemos, Eduardo Martinelli de Lima, Luciane Macedo de Menezes, Susana Maria Deon Rizzatto, Paulo Ricardo Baccarin Matje, and Roberto Vanin Pinto Ribeiro. "Eruption rates of lower second premolars at different development stages evaluated with cone-beam computed tomography." Angle Orthodontist 87, no. 4 (September 29, 2016): 570–75. http://dx.doi.org/10.2319/071116-548.1.

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ABSTRACT Objective: To evaluate and compare the eruption rates of lower second premolars (LPm2) at different developmental stages using cone-beam computed tomography (CBCT). Materials and Methods: Retrospectively, 31 individuals (9.77 ± 1.25 years) had their LPm2 scored according to the Demirjian method, and afterwards they were split into three groups according to developmental stage, as follows: D = complete-formed crowns; E = root length less than crown height; and F = root length greater than or equal to crown height. Linear distances from the LPm2 crown tip to the anatomical reference lin

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Long, Jaclyn, Peter Darroch, Kah Fei Wan, Kok Choi Kong, Nicholas Ktistakis, Nigel J. Pyne, and Susan Pyne. "Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools." Biochemical Journal 391, no. 1 (September 26, 2005): 25–32. http://dx.doi.org/10.1042/bj20050342.

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We have shown previously that LPPs (lipid phosphate phosphatases) reduce the stimulation of the p42/p44 MAPK (p42/p44 mitogen-activated protein kinase) pathway by the GPCR (G-protein-coupled receptor) agonists S1P (sphingosine 1-phosphate) and LPA (lysophosphatidic acid) in serum-deprived HEK-293 cells [Alderton, Darroch, Sambi, McKie, Ahmed, N. J. Pyne and S. Pyne (2001) J. Biol. Chem. 276, 13452–13460]. In the present study, we now show that this can be blocked by pretreating HEK-293 cells with the caspase 3/7 inhibitor, Ac-DEVD-CHO [N-acetyl-Asp-Glu-Val-Asp-CHO (aldehyde)]. Therefore LPP2 a

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Lin, Songbai, Sei-Jung Lee, Hyunsuk Shim, Jerold Chun, and C. Chris Yun. "The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine." American Journal of Physiology-Gastrointestinal and Liver Physiology 299, no. 5 (November 2010): G1128—G1138. http://dx.doi.org/10.1152/ajpgi.00321.2010.

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Lysophosphatidic acid (LPA) is a lipid mediator that mediates several effects that promote cancer progress. The LPA receptor type 2 (LPA2) expression is often elevated in several types of cancers, including colorectal cancer (CRC). In this study, we investigated the role of LPA2 in the development of intestinal adenomas by comparing Apc Min/+ mice with Apc Min/+ /Lpar2 −/− mice. There were 50% fewer intestinal adenomas in Apc Min/+ /Lpar2 −/− mice than Apc Min/+ mice. Smaller-size adenomas (<1 mm) were found at higher frequencies in Apc Min/+ /Lpar2 −/− mice compared with Apc Min/+ mice at

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Liu, Dong, Chahnaz Kebaier, Nazzy Pakpour, Althea A. Capul, Stephen M. Beverley, Phillip Scott, and Jude E. Uzonna. "Leishmania major Phosphoglycans Influence the Host Early Immune Response by Modulating Dendritic Cell Functions." Infection and Immunity 77, no. 8 (June 1, 2009): 3272–83. http://dx.doi.org/10.1128/iai.01447-08.

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ABSTRACT The precise role of Leishmania glycoconjugate molecules including phosphoglycans (PGs) and lipophosphoglycan (LPG) on host cellular responses is still poorly defined. Here, we investigated the interaction of Leishmania major LPG2 null mutant (lpg2 − ), which lacks both PGs and LPG, with dendritic cells (DCs) and the subsequent early immune response in infected mice. Surprisingly, the absence of phosphoglycans did not influence expression pattern of major histocompatibility complex class II (MHC II), CD40, CD80, and CD86 on DCs in vitro and in vivo. However, lpg2 − L. major induced sig

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Geng, Hui, Rongpei Lan, Yaguang Liu, Wei Chen, Meng Wu, Pothana Saikumar, Joel M. Weinberg, and Manjeri A. Venkatachalam. "Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion." American Journal of Physiology-Renal Physiology 320, no. 3 (March 1, 2021): F359—F374. http://dx.doi.org/10.1152/ajprenal.00494.2020.

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Lysophosphatidic acid (LPA) increases platelet-derived growth factor-B (PDGFB) and connective tissue growth factor (CTGF) production and secretion by proximal tubule (PT) cells through LPA2 receptor-Gqα-αvβ6-integrin-mediated activation of transforming growth factor-β1 (TGFB1). LPA2, β6-integrin, PDGFB, and CTGF increase in kidneys after ischemia-reperfusion injury (IRI), coinciding with fibrosis. The TGFB1 receptor antagonist SD-208 prevents increases of β6-integrin, TGFB1-SMAD signaling, and PDGFB/CTGF expression after IRI and ameliorates fibrosis (Geng H, Lan R, Singha PK, Gilchrist A, Wein

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Zhang, Weiqiang, Himabindu Penmatsa, Aixia Ren, Chandanamali Punchihewa, Andrew Lemoff, Bing Yan, Naoaki Fujii, and Anjaparavanda P. Naren. "Functional regulation of cystic fibrosis transmembrane conductance regulator-containing macromolecular complexes: a small-molecule inhibitor approach." Biochemical Journal 435, no. 2 (March 29, 2011): 451–62. http://dx.doi.org/10.1042/bj20101725.

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CFTR (cystic fibrosis transmembrane conductance regulator) has been shown to form multiple protein macromolecular complexes with its interacting partners at discrete subcellular microdomains to modulate trafficking, transport and signalling in cells. Targeting protein–protein interactions within these macromolecular complexes would affect the expression or function of the CFTR channel. We specifically targeted the PDZ domain-based LPA2 (type 2 lysophosphatidic acid receptor)–NHERF2 (Na+/H+ exchanger regulatory factor-2) interaction within the CFTR–NHERF2–LPA2-containing macromolecular complexe

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Li, Chunying, Keanna S. Dandridge, Anke Di, Kevin L. Marrs, Erica L. Harris, Koushik Roy, John S. Jackson, et al. "Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions." Journal of Experimental Medicine 202, no. 7 (October 3, 2005): 975–86. http://dx.doi.org/10.1084/jem.20050421.

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The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel localized primarily at the apical or luminal surfaces of epithelial cells that line the airway, gut, and exocrine glands; it is well established that CFTR plays a pivotal role in cholera toxin (CTX)-induced secretory diarrhea. Lysophosphatidic acid (LPA), a naturally occurring phospholipid present in blood and foods, has been reported to play a vital role in a variety of conditions involving gastrointestinal wound repair, apoptosis, inflammatory bowel disease, and diarrhea. Here we show, for the

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Jones, M. L., C. Martoni, H. Chen, W. Ouyang, T. Metz, and S. Prakash. "Deconjugation of Bile Acids with Immobilized Genetically EngineeredLactobacillus plantarum80(pCBH1)." Applied Bionics and Biomechanics 2, no. 1 (2005): 31–38. http://dx.doi.org/10.1155/2005/380659.

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Bile acids are important to normal human physiology. However, bile acids can be toxic when produced in pathologically high concentrations in hepatobileary and other diseases. This study shows that immobilized genetically engineeredLactobacillus plantarum80 (pCBH1) (LP80 (pCBH1)) can efficiently hydrolyze bile acids and establishes a basis for their use. Results show that immobilized LP80 (pCBH1) is able to effectively break down the conjugated bile acids into glycodeoxycholic acid (GDCA) and taurodeoxycholic acid (TDCA) with bile salt hydrolase (BSH) activities of 0.17 and 0.07 μmol DCA/mg CDW

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Capul, Althea A., Suzanne Hickerson, Tamara Barron, Salvatore J. Turco, and Stephen M. Beverley. "Comparisons of Mutants Lacking the Golgi UDP-Galactose or GDP-Mannose Transporters Establish that Phosphoglycans Are Important for Promastigote but Not Amastigote Virulence in Leishmania major." Infection and Immunity 75, no. 9 (July 2, 2007): 4629–37. http://dx.doi.org/10.1128/iai.00735-07.

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ABSTRACT Abundant surface Leishmania phosphoglycans (PGs) containing [Gal(β1,4)Man(α1-PO4)]-derived repeating units are important at several points in the infectious cycle of this protozoan parasite. PG synthesis requires transport of activated nucleotide-sugar precursors from the cytoplasm to the Golgi apparatus. Correspondingly, null mutants of the L. major GDP-mannose transporter LPG2 lack PGs and are severely compromised in macrophage survival and induction of acute pathology in susceptible mice, yet they are able to persist indefinitely and induce protective immunity. However, lpg2 − L. m

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Xu, Hong, Jun Yan, Yiming Huang, and Suzanne T. Ildstad. "The Early Rejection of Allogeneic BMC by Macrophages or NK Cells Is TRIF Signaling Dependent." Blood 120, no. 21 (November 16, 2012): 1883. http://dx.doi.org/10.1182/blood.v120.21.1883.1883.

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Abstract Abstract 1883 The barrier for rejection of allogeneic bone marrow cells (BMC) has been attributed primarily to adaptive immunity, especially T cell immune responses. Significant progress has been made in developing immune-based nonmyeloablative conditioning strategies to achieve mixed chimerism in bone marrow transplantation (BMT) with targeting of T cells. The role of the innate immune system in BMC allorejection has not been adequately addressed. The fact that when T cells are targeted, alloengraftment requires additional conditioning from nonspecific reagents, such as irradiation a

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Rajendran, Sujeevan, Jung Heo, Yong Jun Kim, Dae Heon Kim, Kisung Ko, Young Koung Lee, Seok Kwi Oh, Chul Min Kim, Jong Hyang Bae, and Soon Ju Park. "Optimization of Tomato Productivity Using Flowering Time Variants." Agronomy 11, no. 2 (February 4, 2021): 285. http://dx.doi.org/10.3390/agronomy11020285.

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The control of flowering time is a major contributing factor to the improvement of crop yield by optimizing plant growth in a crop cycle. Genetic variants that determine flowering time can provide insights into optimizing flowering time for higher yields and other beneficial traits in tomato crops. Here, we examined a collection of flowering time variants to assess their effects on biomass and total tomato yields. Five late flowering (lf), thirteen large plant (lp), and seven floral homeotic (fh) mutants were identified as flowering time variants that could be rearranged according to leaf prod

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Grimm, Dorothee, Christian H. Eggers, Melissa J. Caimano, Kit Tilly, Philip E. Stewart, Abdallah F. Elias, Justin D. Radolf, and Patricia A. Rosa. "Experimental Assessment of the Roles of Linear Plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the Infectious Cycle." Infection and Immunity 72, no. 10 (October 2004): 5938–46. http://dx.doi.org/10.1128/iai.72.10.5938-5946.2004.

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ABSTRACT Borrelia burgdorferi, which causes Lyme disease in humans, has an unusual genome composed of a linear chromosome and up to 21 extrachromosomal elements. Experimental data suggest that two of these elements, linear plasmids lp25 and lp28-1, play essential roles for infectivity in mice. In this study, we prove the essential natures of these two plasmids by selectively displacing lp25 or lp28-1 in an infectious wild-type clone with incompatible shuttle vectors derived from the native plasmids, rendering the respective transformants noninfectious to mice. Conversely, restoration of plasmi

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Xu, Qilong, Sunita V. Seemanapalli, Larry Lomax, Kristy McShan, Xin Li, Erol Fikrig, and Fang Ting Liang. "Association of Linear Plasmid 28-1 with an Arthritic Phenotype of Borrelia burgdorferi." Infection and Immunity 73, no. 11 (November 2005): 7208–15. http://dx.doi.org/10.1128/iai.73.11.7208-7215.2005.

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ABSTRACT Borrelia burgdorferi, the Lyme disease spirochete, has a genome comprised of a linear chromosome and up to 21 plasmids. Loss of plasmids is associated with decreased infectivity and pathogenicity. Sixteen transformants were generated by transforming the noninfectious clone 5A13 with the recombinant plasmid pBBE22. The transformants were classified into nine groups based on plasmid content analysis. An infectivity study revealed that all nine transformants examined, each of which represented one of the plasmid patterns, were infectious in mice with severe combined immunodeficiency (SCI

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Ferreira dos Santos, Thalis, Tauá Alves Melo, Milena Evangelista Almeida, Rachel Passos Rezende, and Carla Cristina Romano. "Immunomodulatory Effects ofLactobacillus plantarumLp62 on Intestinal Epithelial and Mononuclear Cells." BioMed Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/8404156.

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Probiotic lactic acid bacteria are known for their ability to modulate the immune system. They have been shown to inhibit inflammation in experiments with animal models, cell culture, and clinical trials. The objective of this study was to elucidate the anti-inflammatory potential ofLactobacillus plantarumLp62, isolated from cocoa fermentation, in a cell culture model. Lp62 inhibited IL-8 production bySalmonellaTyphi-stimulated HT-29 cells and prevented the adhesion of pathogens to these epithelial cells. The probiotic strain was able to modulate TNF-α, IL1-β, and IL-17 secretion by J774 macro

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Sexton, Jessica A., and Joseph P. Vogel. "Regulation of Hypercompetence in Legionella pneumophila." Journal of Bacteriology 186, no. 12 (June 15, 2004): 3814–25. http://dx.doi.org/10.1128/jb.186.12.3814-3825.2004.

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ABSTRACT Although many bacteria are known to be naturally competent for DNA uptake, this ability varies dramatically between species and even within a single species, some isolates display high levels of competence while others seem to be completely nontransformable. Surprisingly, many nontransformable bacterial strains appear to encode components necessary for DNA uptake. We believe that many such strains are actually competent but that this ability has been overlooked because standard laboratory conditions are inappropriate for competence induction. For example, most strains of the gram-nega

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Lin, Songbai, and C. C. Yun. "Deletion of LPA2 Attenuates Murine Colitis." Gastroenterology 140, no. 5 (May 2011): S—838. http://dx.doi.org/10.1016/s0016-5085(11)63476-8.

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Ma, Deqin, David G. Russell, Stephen M. Beverley, and Salvatore J. Turco. "Golgi GDP-mannose Uptake RequiresLeishmania LPG2." Journal of Biological Chemistry 272, no. 6 (February 7, 1997): 3799–805. http://dx.doi.org/10.1074/jbc.272.6.3799.

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JAWORSKI, Cynthia, and Graeme WISTOW. "LP2, a differentiation-associated lipid-binding protein expressed in bovine lens." Biochemical Journal 320, no. 1 (November 15, 1996): 49–54. http://dx.doi.org/10.1042/bj3200049.

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A 13 kDa protein from bovine lens was identified and characterized by protein microsequencing and by rapid amplification of cDNA ends (RACE) PCR. Its complete sequence shows that this protein belongs to a family of fatty acid-binding proteins (FABPs), including myelin and adipocyte P2, that are associated with cellular differentiation. The bovine lens protein, designated LP2, shows very close similarity to human epidermal FABP (eFABP) and human eFABP was detected in human lens, suggesting that the two proteins might be orthologous. Reverse transcriptase–PCR (RT–PCR) was used to compare express

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Eckford, Paul D. W., and Christine E. Bear. "Targeting the regulation of CFTR channels." Biochemical Journal 435, no. 2 (March 29, 2011): e1-e4. http://dx.doi.org/10.1042/bj20110461.

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In this issue of the Biochemical Journal, Zhang et al. reveal a new strategy for modifying the regulated function of CFTR (cystic fibrosis transmembrane conductance regulator) on the apical surface of epithelial cells. Simply stated, these authors tested the idea that the cAMP-dependent channel activity of CFTR could be effectively enhanced by disruption of a protein–protein interaction which is normally inhibitory for the production of cAMP. This particular protein–protein interaction [between the PDZ motif of LPA2 (type 2 lysophosphatidic acid receptor) and the scaffold protein Nherf2 (Na+/H

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Nasrallah, Gheyath K., Elizabeth Gagnon, Dennis J. Orton, and Rafael A. Garduño. "ThehtpABoperon ofLegionella pneumophilacannot be deleted in the presence of thegroEchaperonin operon ofEscherichia coli." Canadian Journal of Microbiology 57, no. 11 (November 2011): 943–52. http://dx.doi.org/10.1139/w11-086.

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HtpB, the chaperonin of the intracellular bacterial pathogen Legionella pneumophila , displays several virulence-related functions in vitro. To confirm HtpB’s role in vivo, host infections with an htpB deletion mutant would be required. However, we previously reported that the htpAB operon (encoding co-chaperonin and chaperonin) is essential. We attempted here to delete htpAB in a L. pneumophila strain carrying the groE operon (encoding the Escherichia coli co-chaperonin and chaperonin). The groE operon was inserted into the chromosome of L. pneumophila Lp02, and then allelic replacement of ht

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Shih, M., H. Ma, E. Nakajima, L. L. David, M. Azuma, and T. R. Shearer. "Biochemical properties of lens-specific calpain Lp85." Experimental Eye Research 82, no. 1 (January 2006): 146–52. http://dx.doi.org/10.1016/j.exer.2005.06.011.

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Lattuada, Pier Luigi. "Transpersonal Psychology as a Science." Integral Transpersonal Journal 11, no. 11 (September 2018): 26–51. http://dx.doi.org/10.32031/itibte_itj_11-lp2.

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In this article, the author will discuss the specificities of transpersonal psychology, exploring how can offer an enormous potential to psychological science, encouraging it to widen its field of application and methods. In doing so the author will offer both some of the answers to the criticism by mainstream psychology, and those ontological and epistemological aspects on which it is based.

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Cieslik, Dietmar, and Johann Linhart. "Steiner minimal trees in Lp2." Discrete Mathematics 155, no. 1-3 (August 1996): 39–48. http://dx.doi.org/10.1016/0012-365x(94)00368-s.

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Kim, Tae-Jung, and Gi-Seong Moon. "Antimicrobial Activity of Lactobacillus plantarum LP2 against Helicobacter pylori." Journal of Food Hygiene and Safety 30, no. 4 (December 30, 2015): 372–75. http://dx.doi.org/10.13103/jfhs.2015.30.4.372.

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Norris, Steven J., Jerrilyn K. Howell, Evelyn A. Odeh, Tao Lin, Lihui Gao, and Diane G. Edmondson. "High-Throughput Plasmid Content Analysis ofBorrelia burgdorferiB31 by Using Luminex Multiplex Technology." Applied and Environmental Microbiology 77, no. 4 (December 17, 2010): 1483–92. http://dx.doi.org/10.1128/aem.01877-10.

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ABSTRACTBorrelia burgdorferi, the causative agent of Lyme disease in North America, is an invasive pathogen that causes persistent multiorgan manifestations in humans and other mammals. Genetic studies of this bacterium are complicated by the presence of multiple plasmid replicons, many of which are readily lost duringin vitroculture. The analysis ofB. burgdorferiplasmid content by plasmid-specific PCR and agarose gel electrophoresis or other existing techniques is informative, but these techniques are cumbersome and challenging to perform in a high-throughput manner. In this study, a PCR-base

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Pallavi, Pogaku, Suresh A, Srinivas P, and Ram Reddy S. "Optimization of lipase production by Staphylococcus sp. Lp12." African Journal of Biotechnology 9, no. 6 (February 8, 2010): 882–86. http://dx.doi.org/10.5897/ajb09.1222.

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Shen, Dongya, Changhui Wang, Chuan Ma, Hakim Mellah, Xiupu Zhang, Hong Yuan, and Wenping Ren. "A novel optical waveguide LP01/LP02 mode converter." Optics Communications 418 (July 2018): 98–105. http://dx.doi.org/10.1016/j.optcom.2018.02.056.

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