Gotowe bibliografie tematyczne / Lung cancer / Rozprawy doktorskie
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Rozprawy doktorskie na temat „Lung cancer”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 25 lipca 2025

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1

Gaskin, Janet. "Radon and Lung Cancer." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39003.

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Background: Lung cancer was the fifth leading cause of mortality globally in 2010, and the leading cause of cancer mortality in Canada, representing 26% of all cancer deaths for both men and women in 2017. Radon is a very modifiable environmental exposure that is the second most important cause of lung cancer. Objectives: The objectives of this thesis are to quantify the lung cancer burden associated with residential radon and to identify the most cost effective mitigation options to reduce residential radon in Canada. Methods: The global burden of lung cancer mortality attributable to radon
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2

Thomas, Akesh, zainab Fatima, and Girendra resident Hoskere. "Lung Cancer in Tennessee." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/69.

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Introduction Lung cancer is the most common cause of cancer-related death in the United States (US). Tobacco smoking is a well-recognized cause of lung cancer. About 2% of the United States (US) population lives in Tennessee (TN). Nearly 21 % of TN adults are current smokers as per 2019 data, compared to 14% across the US. The percentage of smokers has historically been high in TN and its surroundings. This can be attributed to the area's socio-economic and cultural characteristics, along with large areas of tobacco farming in the region. This increases the risk of lung cancer in the TN popula
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3

Ruiz, Rossana, Marco Galvez-Nino, Ebert Poquioma, et al. "Lung Cancer in Peru." Elsevier Inc, 2020. http://hdl.handle.net/10757/652438.

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Peru is a South American nation with a growing and aging population of 31 million people with a life expectancy at birth of 76.7 years. The country is divided into 25 regions, 79% of the population is urban, and Lima, the capital, concentrates more than a third of the population.1 Although Peru is an upper-middle-income country, health expenditure represents only 5.1% of the gross domestic product, which is lower than the average of Latin America and the Caribbean (LATAM) (8.56%).2 Out-of-pocket health expenditure is 30.9%.3 Peru has a comprehensive National Cancer Plan and two population-base
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4

Salvati, Valentina. "Development of effective lung cancer therapies based on lung cancer stem cella targeting." Doctoral thesis, Università di Catania, 2015. http://hdl.handle.net/10761/4035.

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Il carcinoma polmonare non a piccole cellule (NSCLC) rappresenta circa l 80% di tutti i tumori al polmone ed è il cancro più comune e più mortale al mondo. Il trattamento convenzionale per il NSCLC in stadio avanzato è stato basato per molto tempo sull uso della chemioterapia, ma con basso impatto sulla sopravvivenza . Una migliore comprensione dei meccanismi molecolari coinvolti nel processo di tumorigenesi e una maggiore capacità nell identificazione di specifiche alterazioni genetiche come bersagli terapeutici, hanno portato ad un significativo avanzamento verso lo sviluppo di terapie più
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5

Şeşen, Mustafa Berkan. "Lung cancer assistant : a hybrid clinical decision support application in lung cancer treatment selection." Thesis, University of Oxford, 2013. https://ora.ox.ac.uk/objects/uuid:e0dd01e4-3f18-49ed-89af-5e81894d4967.

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We describe an online clinical decision support (CDS) system, Lung Cancer Assistant (LCA), which we have developed to aid the clinicians in arriving at informed treatment decisions for lung cancer patients at multidisciplinary team (MDT) meetings. LCA integrates rule-based and probabilistic decision support within a single platform. To our knowledge, this is the first time this has been achieved in the context of CDS in cancer care. Rule-based decision support is achieved by an original ontological guideline rule inference framework that operates on a domain-specific module of Systematized Nom
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6

Turner, Nicola Jane. "Cancer in older people : studies in lung cancer." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399662.

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7

OLSSON, MILLA, and CAROLINE ROSELL. "Telemedicine for Lung Cancer Patients." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-136951.

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Den svenska sjukvården står idag för ett antal utmaningar om den skall fortsatt kunna erbjuda god service som vårdgivare och vara attraktiv som arbetsgivare. Bland annat diskuteras frågor som förvärrad platsbrist, läkarbrist samt avstånd till specialistsjukvård. På Karolinska Universitetssjukhuset i Solna ligger Radiumhemmet och där behandlas bland annat lungcancerpatienter. Där diskuteras huruvida telemedicin kan vara en möjlig väg för att lösa ovanstående problem. Denna uppsats utreder på vilket sätt telemedicin kan användas på Radiumhemmet för lungcancerpatienter. För att kunna utreda en te
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8

Basran, Parminder S. "Optimisation of lung cancer treatment." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq22568.pdf.

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9

Tinnemans, Monique Maria Franciska Johanna. "Cytokinetic analysis of lung cancer." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1996. http://arno.unimaas.nl/show.cgi?fid=7289.

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10

Richards, Elizabeth. "Molecular profiling of lung cancer." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24546.

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Cisplatin is a first line chemotherapeutic agent for lung cancer however, although patients may respond to therapy, resistance often develops with tumour recurrence and disease progression. Somatic alterations in the tumour may alter therapeutic responses. Consequently a model of cisplatin resistance in lung cancer derived A549 cells has been created to examine the genomic changes that occur as chemo-resistance develops. Drug resistance was induced in A549 cells through multiple rounds of cisplatin dosage and recovery over two different time courses. The concentration of cisplatin required to
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11

Bingula, Rea. "Non-small cell lung cancer, immunity and microbiota : laying ground for the gut-lung-lung cancer axis in human subjects." Thesis, Université Clermont Auvergne‎ (2017-2020), 2019. http://www.theses.fr/2019CLFAS009.

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Le cancer du poumon est la principale cause de décès par cancer dans le monde. En dépit de la variété de traitements disponibles, tels que la chirurgie, la chimiothérapie, la radiothérapie et l’immunothérapie, la survie moyenne à 5 ans est de 60 %. L’une des raisons sous-jacente est une très grande variabilité de réponse au traitement, expliquée par les antécédents génétiques du patient et depuis peu par son microbiote. Le terme « microbiote » regroupe les bactéries, les archées, les champignons, les virus et les protistes qui colonisent notre organisme. Des études utilisant des modèles animau
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12

Grewal, Amardeep Singh. "Prevalence and Outcome of Lung Cancer in Lung Transplant Recipients." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17295910.

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Lung transplant is the only available therapy for patients with advanced lung disease. The goal of this study was to examine the prevalence, origin, management and outcome of lung cancer in recipients of lung transplant at the Brigham and Women’s Hospital. We conducted a retrospective chart review of all lung transplantations in our institution from January 1990 until June 2012. The prevalence of lung cancer in the explanted lung was 6 (1.2%) of 462 and all cases were in subjects with lung fibrosis. All 4 subjects with lymph node involvement died of causes related to the malignancy. Nine (1.9
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13

Li, Xinjun. "Familial risks for cancer with reference to lung cancer /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-007-9/.

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14

Moore, S. "The social construction of lung cancer : an analysis of representations of lung cancer in UK media." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/372913/.

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Lung cancer is a commonly occurring cancer in the United Kingdom. However, little attention has been directed at understanding meanings in relation to the disease, and how these are socially constructed. This thesis examines representations of lung cancer in media stories to explore how the disease is constructed and with what effects. Drawing on a social constructionist approach, media stories are understood as public places or sites in which meanings about the world are produced and reproduced through language and discourse. Media portrayals of lung cancer are examined for their content and
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15

Hillinger, Sven. "Immune targeted therapy for lung cancer /." Zürich, 2006. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253405.

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16

Buttery, Robert Christians. "Integrin affinity modulation and lung cancer." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29025.

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Recent work has shown that the transmembrane protein CD98 is able to influence the affinity with which β1 integrins bind to extracellular ligands. The first part of this thesis presents confocal microscopy and co-immunoprecipitation experiments that confirm the physical juxtaposition of the two proteins within the cell membrane, suggesting a direct functional link between the two. It also demonstrated that cross-linking CD98 stimulates both phosphoinositide 3-kinase intracellular signalling and increased β1 integrin-dependent cellular adhesion. Because of the role of CD98 in integrin affinity
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17

Tran, Vanessa Hoang Medical Sciences Faculty of Medicine UNSW. "Breath biomarkers associated with lung cancer." Publisher:University of New South Wales. Medical Sciences, 2009. http://handle.unsw.edu.au/1959.4/43717.

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Lung cancer (LC) is often diagnosed at advanced stage and as a result, survival rates are low. Recent studies describe exhaled breath and exhaled breath condensate (EBC) as a potential non-invasive method of sampling the airways for assessing inflammation of the respiratory system, and possibly for the early detection of LC. It was hypothesised that higher concentrations of markers and protein will be present in the EBC of LC patients compared to those of normal controls and healthy smokers, and may aid in assessing lung status. Methods: The gaseous phase of breath was investigated for volati
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18

Hochstenbag, Monique. "Imaging in clinical lung cancer staging." [Maastricht] : Maastricht : UPM, Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 2003. http://arno.unimaas.nl/show.cgi?fid=8287.

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19

Buys, Timon Paul Hermus. "Clonal evoluation and lung cancer pharmacogenomics." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/9532.

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Background: Lung cancer is the world's leading cause of cancer death, with a 5 year survival rate of ~16%. Several factors contribute to this poor prognosis: the limited detection of disease at treatable stages, the high metastatic potential of any primary tumour, and the variable effectiveness of chemotherapy. We applied high resolution whole genome profiling technologies to uncover genes associated with specific lung cancer phenotypes and to delineate clonal relationships between tumours. Hypotheses: (i) Shared genetic features in tumours from the same patient are evidence of a common progen
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20

Wilkinson, Pauline. "Lung cancer in Ireland : 1991-1992." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336721.

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21

Dial, Christian W. "Adaptive Radiation Therapy for Lung Cancer." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3579.

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Prognosis for lung cancer patients remains poor. For those receiving radiation therapy, local control and survival have been shown to improve with increased doses; however, deliverable dose is often limited by associated toxicity. Therefore, methods that reduce dose to normal tissues and allow isotoxic escalation are desirable. Adaptive radiation therapy seeks to improve treatment by modifying the initial plan throughout delivery, and has been shown to decrease normal tissue dose. Studies to date suggest a trend of increasing benefit with increases in replanning frequency; however, replanning
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22

Rattican, Debra. "Symptom Clusters in Lung Cancer Patients." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/352.

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SYMPTOM CLUSTERS IN LUNG CANCER PATIENTS By Debra Rattican, PhD, RN A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Major Director: Debra E. Lyon, PhD. Professor and Chair Family and Community Health Nursing The purpose of the study was to examine selected relationships among symptoms common to individuals with lung cancer. The specific aims were: 1) To examine the relationship between the symptoms of dyspnea and anxiety in patients with lung cancer. 2) To exam
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23

Kurtyka, Courtney A. "Novel Therapeutic Strategies in Lung Cancer." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5363.

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Lung cancer is the leading cause of cancer-related death and the second most diagnosed cancer in the United States. Unfortunately, many patients either do not have any common mutations for which there are already targetable agents, or they eventually become resistant to these compounds. As such, there is a high demand for new, effective methods of treating this disease as well as predicting patient prognosis and potential benefit from chemotherapy. In this work, numerous strategies for treating lung cancer are explored. The first method described here is through the use of a pan-early 2 factor
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24

Lee, Richard. "An improved system for lung cancer diagnosis using lung cell images." Diss., Online access via UMI:, 2006.

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25

Tian, Fei. "Effect of the Hedgehog Pathway inhibitor GDC-0449 in lung cancer cells and lung cancer stem cells." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-156374.

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The cancer stem cell hypothesis implicates that tumor cell population is heterogeneous with relatively well-differentiated cells and poorly-differentiated cells. Only the small population of tumourigenic poorly-differentiated CSCs can escape the normal limits of self-renewal and has the ability to proliferate and maintain the malignant growth of the tumor. One characteristic of stem cell is that the ability to exclude DNA dyes, such as Hoechst 33342 via the over-expression of ATP-binding cassette transporters (ABC transporters) on the cell membrane. It makes the detecting of the stem cell pos
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26

Brena, Romulo Martin. "Aberrant DNA methylation in human non-small cell lung cancer." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1172083621.

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27

陳潔盈 and Kit-ying Loucia Chan. "Expression analysis of Candidate cancer genes in non-small cell lung cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011163.

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28

Cong, Chunling. "Statistical Analysis and Modeling of Breast Cancer and Lung Cancer." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3563.

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The objective of the present study is to investigate various problems associate with breast cancer and lung cancer patients. In this study, we compare the effectiveness of breast cancer treatments using decision tree analysis and come to the conclusion that although certain treatment shows overall effectiveness over the others, physicians or doctors should discretionally give different treatment to breast cancer patients based on their characteristics. Reoccurrence time of breast caner patients who receive different treatments are compared in an overall sense, histology type is also taken into
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Sarvi, Sana. "Small cell lung cancer and cancer stem cell-like cells." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9542.

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Small cell lung cancer (SCLC) is a highly aggressive malignancy with extreme mortality and morbidity. Although initially chemo- and radio-sensitive, almost inevitable recurrence and resistance occurs. SCLC patients often present with metastases, making surgery not feasible. Current therapies, rationally designed on underlying pathogenesis, produce in vitro results, however, these have failed to translate into satisfactory clinical outcomes. Recently, research into cancer stem cells (CSCs) has gained momentum and form an attractive target for novel therapies. Based on this concept, CSCs are the
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30

De, Souza Nicosha. "Molecular epidemiology of lung cancer in the Liverpool Lung Project (LLP) cohort." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2006199/.

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The primary aim of the project was to evaluate the epidemiological and genetic susceptibility factors associated with lung cancer, in the Liverpool Lung Project (LLP) population. The associated datasets available for research with the LLP dataset (questionnaire) were: Office of National Statistics (ONS), Health Episode Statistics (HES) data with comorbidity data, single nucleotide polymorphism (SNP) data of 570 cases from Liverpool, 3000 controls from the 1958 Birth Cohort. The epidemiological (HES) data was used to study the effect of Charlson (CCI) and Elixhauser comorbidity index (ECI) on t
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31

Chan, Kit-ying Loucia. "Expression analysis of Candidate cancer genes in non-small cell lung cancer /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38480360.

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32

Keller, Elizabeth Greer. "Novel chemotherapeutics against lung and colon cancer." Click here for download, 2010. http://proquest.umi.com.ps2.villanova.edu/pqdweb?did=1961333981&sid=1&Fmt=2&clientId=3260&RQT=309&VName=PQD.

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33

Maltt, N. D. "Diagnosis of lung cancer by raman spectroscopy." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492488.

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lung cancer patients from 'at risk' controls and 'at risk' control subjects from healthy control subjects. Porphyrin-containing substances were higher in the 'at risk' controls than either the healthy controls or the lung cancer patients. Additionally the induced sputum from the three groups was analysed using Surface-enhanced Desorption-Ionization Time-of-flight mass spectrometry which also distinguished the three groups. A mini fibre optic probe was used in conjunction with shifted subtracted Raman spectroscopy to analyse normal and malignant ex vivo lung tissue from 7 patients, obtained fro
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34

Tomai, Evangelia. "Gap junctional communication in lung cancer cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/MQ54488.pdf.

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35

Smit, Egbert Frederik. "Aspects of palliative chemotherapy for lung cancer." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1990. http://irs.ub.rug.nl/ppn/292220588.

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36

Oosterhout, Anselmus Gerardus Maria van. "Small cell lung cancer and brain metastasis." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=6643.

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37

Seute, Tatjana. "Neurologic complications in small cell lung cancer." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=9520.

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38

Belderbos, Josepha Sophia Antonia. "Radiotherapy in lung cancer: a moving field." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/45315.

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39

Wu, Mau-Ching. "Mouse models of human lung cancer development." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624711.

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40

Lake, Sarah Louise. "Genetic analysis of LPHH1 in lung cancer." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404506.

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This thesis contends that the monarch-centred view of the masque, which has prevailed since the publication in the 1960s and 1970s of Stephen Orgel's seminal works on the genre, needs to be challenged in the light of recent scholarship on the cultural agency of other members of the royal family. In my introduction I argue that while the New Historicism has been crucial in elucidating the theatricalization of power in the early Stuart court, its insistence on the inevitability of the collusion between art and sovereign power needs to be questioned. The masque has long been seen as a monolithic
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41

Salem, Ahmed. "Validating non-invasive therapeutic lung cancer biomarkers." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/validating-noninvasive-therapeutic-lung-cancer-biomarkers(edeb97f1-b1d4-43a3-bafb-8c7e1fa9d8c7).html.

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Lung cancer is the leading cause of cancer death and a priority research area. There is an unmet need to develop biomarkers to enable patient selection and stratification in future lung cancer trials. This thesis aimed to validate non-invasive therapeutic lung cancer biomarkers. The investigated biomarkers were derived from imaging techniques used in routine healthcare (computed tomography and [18F]fludeoxyglucose (FDG) positron emission tomography (PET)) and research-domain imaging methods of hypoxia (multi-parametric magnetic resonance imaging (MRI) and [18F]fluoroazomycin arabinoside (FAZA)
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42

Gray, Eoin. "Validating and updating lung cancer prediction models." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/19206/.

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Lung cancer is a global disease that affect millions of individuals worldwide. Additionally, the disease is beset with a poor 5-year survival rate, a direct consequence of a low early stage diagnosis rate. In an attempt to improve lung cancer prognosis, individuals at high risk of developing lung cancer should be identified for periodic screening. Prediction models are devised to predict an individual’s risk of developing a disease over a specified time period. These can be used to identify high risk individuals and be made publically available to allow individuals’ to be conscience of their ow
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43

Taylor, Fiona. "Biomarkers of lung cancer risk and progression." Thesis, University of Sheffield, 2019. http://etheses.whiterose.ac.uk/22855/.

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Lung cancer causes high mortality because most people present late with advanced disease that is not amenable to curative treatment. Screening high-risk groups with low dose CT imaging of the thorax has been shown to reduce lung cancer mortality by 20%, but at the cost of a high false positive rate. Population stratification with molecular biomarkers could improve the cost-benefit of lung cancer screening programmes and reduce false positives. Tumour cells shed DNA into the blood, enabling tumour-derived genetic alterations to be detected non-invasively by analysing circulating cell-free DNA (
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44

Forrest, Lynne Fiona. "Intervention-generated inequalities in lung cancer care." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2396.

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Lung cancer survival is poorer in more socio-economically deprived patient groups. It has been suggested that socio-economic inequalities in receipt of, and time to, treatment may contribute to inequalities in cancer outcome. Unintended variations in outcome that result from the way that interventions are organised and delivered have been described as intervention-generated inequalities. The aim of this thesis was to determine if there are socio-economic inequalities in lung cancer care and, if so, to identify where on the pathway of care these inequalities might occur: looking at receipt of t
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45

Macaulay, Valentine. "Growth regulation in small cell lung cancer." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47547.

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46

Sinicropi-Yao, Sara Lu-Ming. "The Role of NOTCH1 in Lung Cancer." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1522064811057979.

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47

Meikle, Claire K. "Platelet-Leukocyte Aggregation in Lung Cancer Patients." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1555937904448281.

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48

Rupniewska, Ewa. "Targeting SRC family kinases in lung cancer." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9234.

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Lung cancer is the commonest cancer killer worldwide. This is mainly due to the rapid development of drug resistance and early metastatic dissemination of the disease. SRC family kinases (SFKs) are frequently over-expressed in various cancers and have been implicated in tumorigenesis through their ability to promote cancer cell proliferation, survival and invasiveness. Therefore, we sought to evaluate the involvement of SFKs in lung cancer biology and assess the possible therapeutic benefits of their inhibition, either alone or in combination with additional treatments. We demonstrate that SRC
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49

Kvarnbrink, Samuel. "The importance og LRIG1 in lung cancer." Thesis, Umeå universitet, Onkologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-57834.

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Weber, Anika Maria. "Targeting ATM/ATR signalling in lung cancer." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:3117219f-5273-4dc7-9a28-c531c708663f.

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Cells respond to the induction of DNA damage with activation of the DNA damage response (DDR), a complex signalling network which orchestrates cell cycle arrest and DNA repair in order to maintain genomic stability and cell viability. Activation of these signalling pathways enables cancer cells to survive DNA damaging chemo- or radiotherapy and contributes to the development of therapy resistance. Therefore, components of the DDR have become attractive targets for chemo- or radiosensitisation. Furthermore, cancer cells frequently exhibit defects in certain DDR components and may, as a conseque
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