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Artykuły w czasopismach na temat "Lung Neoplasms/metabolism"

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Llewellyn, David C., Rajaventhan Srirajaskanthan, Royce P. Vincent, et al. "Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis." Endocrine Connections 10, no. 4 (2021): 447–61. http://dx.doi.org/10.1530/ec-21-0071.

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Calcitonin-secreting neuroendocrine neoplasms of the lung are rare, with few cases reported in the literature. Differentiating between medullary thyroid carcinoma and an ectopic source of calcitonin secretion can represent a complex diagnostic conundrum for managing physicians, with cases of unnecessary thyroidectomy reported in the literature. This manuscript reports a case of ectopic hypercalcitonaemia from a metastatic neuroendocrine neoplasm of the lung with concurrent thyroid pathology and summarises the results of a systematic review of the literature. Medical Literature Analysis and Ret
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Ronot, Maxime, and Marie-Pierre Vullierme. "Morphological imaging of gastrointestinal and lung neuroendocrine neoplasms." Current Opinion in Endocrine and Metabolic Research 19 (August 2021): 1–7. http://dx.doi.org/10.1016/j.coemr.2021.05.001.

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Michalak, Slawomir, Joanna Rybacka-Mossakowska, Wojciech Ambrosius, et al. "The Markers of Glutamate Metabolism in Peripheral Blood Mononuclear Cells and Neurological Complications in Lung Cancer Patients." Disease Markers 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/2895972.

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Objective. To evaluate the involvement of glutamate metabolism in peripheral blood mononuclear cells (PBMC) in the development of neurological complications in lung cancer and during chemotherapy. Methods. The prospective study included 221 lung cancer patients treated with chemotherapeutics. Neurological status and cognitive functions were evaluated at baseline and after 6-month follow-up. Glutamate level, the activities of glutaminase- (GLS-) glutamate synthetizing enzyme, glutamate dehydrogenase (GDH), and glutamate decarboxylase catalyzing glutamate degradation were analyzed in PBMC and in
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Couvelard, Anne, Jérôme Cros, Atsuko Kasajima, Günter Klöppel, and Aurélie Cazes. "Digestive and lung high-grade neuroendocrine neoplasms: Update and challenging issues." Current Opinion in Endocrine and Metabolic Research 18 (June 2021): 224–29. http://dx.doi.org/10.1016/j.coemr.2021.04.002.

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Wong, Cheuk Lik, Matthew Tai Fai Kwan, Sammy Pak Lam Chen, Mei Tik Leung, Tim Wai Chan, and Vicki Ho Kee Tam. "ODP049 Oncocytic adrenocortical carcinoma misdiagnosed as renal oncocytoma and use of urinary steroid profiling in disease monitoring after mitotane therapy." Journal of the Endocrine Society 6, Supplement_1 (2022): A62. http://dx.doi.org/10.1210/jendso/bvac150.128.

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Abstract Introduction Oncocytic adrenocortical carcinoma (OAC) is a rare, more indolent variant of adrenocortical carcinoma (ACC). With fewer than 70 cases reported in the English literature, the biological behavior and its response to treatment are poorly characterized. The distinction of OAC from other oncocytic neoplasms (e. g., kidneys) and variants of renal cell carcinoma (RCC) may pose diagnostic challenge pathologically. Urine steroid profiling (USP) of OAC has not been previously reported. Case description A 65-year-old Chinese man was incidentally found to have a large left upper abdo
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Modica, Roberta, Anna La Salvia, Alessia Liccardi, et al. "Lipid Metabolism and Homeostasis in Patients with Neuroendocrine Neoplasms: From Risk Factor to Potential Therapeutic Target." Metabolites 12, no. 11 (2022): 1057. http://dx.doi.org/10.3390/metabo12111057.

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Lipid metabolism is known to be involved in tumorigenesis and disease progression in many common cancer types, including colon, lung, breast and prostate, through modifications of lipid synthesis, storage and catabolism. Furthermore, lipid alterations may arise as a consequence of cancer treatment and may have a role in treatment resistance. Neuroendocrine neoplasms (NENs) are a heterogeneous group of malignancies with increasing incidence, whose mechanisms of cancer initiation and progression are far from being fully understood. Alterations of lipid metabolism may be common across various can
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Espinosa-Olarte, Paula, Anna La Salvia, Maria C. Riesco-Martinez, Beatriz Anton-Pascual, and Rocio Garcia-Carbonero. "Chemotherapy in NEN: still has a role?" Reviews in Endocrine and Metabolic Disorders 22, no. 3 (2021): 595–614. http://dx.doi.org/10.1007/s11154-021-09638-0.

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AbstractNeuroendocrine neoplasms (NENs) comprise a broad spectrum of tumors with widely variable biological and clinical behavior. Primary tumor site, extent of disease, tumor differentiation and expression of so matostatin receptors, proliferation and growth rates are the major prognostic factors that determine the therapeutic strategy. Treatment options for advanced disease have considerably expanded in recent years, particularly for well differentiated tumors (NETs). Novel drugs approved over the past decade in this context include somatostatin analogues and 177Lu-oxodotreotide for somatost
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Kasajima, Atsuko, and Günter Klöppel. "Neuroendocrine neoplasms of lung, pancreas and gut: a morphology-based comparison." Endocrine-Related Cancer 27, no. 11 (2020): R417—R432. http://dx.doi.org/10.1530/erc-20-0122.

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The bronchopulmonary (BP) and gastroenteropancreatic (GEP) organ systems harbor the majority of the neuroendocrine neoplasms (NENs) of the body, comprising 20 and 70% of all NENs, respectively. Common to both NEN groups is a classification distinguishing between well- and poorly differentiated NENs associated with distinct genetic profiles. Differences between the two groups concern the reciprocal prevalence of well and poorly differentiated neoplasms, the application of a Ki67-based grading, the variety of histological patterns, the diversity of hormone expression and associated syndromes, th
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Volante, Marco, Ozgur Mete, Giuseppe Pelosi, Anja C. Roden, Ernst Jan M. Speel, and Silvia Uccella. "Molecular Pathology of Well-Differentiated Pulmonary and Thymic Neuroendocrine Tumors: What Do Pathologists Need to Know?" Endocrine Pathology 32, no. 1 (2021): 154–68. http://dx.doi.org/10.1007/s12022-021-09668-z.

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AbstractThoracic (pulmonary and thymic) neuroendocrine tumors are well-differentiated epithelial neuroendocrine neoplasms that are classified into typical and atypical carcinoid tumors based on mitotic index cut offs and presence or absence of necrosis. This classification scheme is of great prognostic value but designed for surgical specimens, only. Deep molecular characterization of thoracic neuroendocrine tumors highlighted their difference with neuroendocrine carcinomas. Neuroendocrine tumors of the lung are characterized by a low mutational burden, and a high prevalence of mutations in ch
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Kalkanis, Alexandros, Dimitrios Papadopoulos, Dries Testelmans, Alexandra Kopitopoulou, Eva Boeykens, and Els Wauters. "Bronchoalveolar Lavage Fluid-Isolated Biomarkers for the Diagnostic and Prognostic Assessment of Lung Cancer." Diagnostics 12, no. 12 (2022): 2949. http://dx.doi.org/10.3390/diagnostics12122949.

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Lung cancer is considered one of the most fatal malignant neoplasms because of its late detection. Detecting molecular markers in samples from routine bronchoscopy, including many liquid-based cytology procedures, such as bronchoalveolar lavage fluid (BALF), could serve as a favorable technique to enhance the efficiency of a lung cancer diagnosis. BALF analysis is a promising approach to evaluating the tumor progression microenvironment. BALF’s cellular and non-cellular components dictate the inflammatory response in a cancer-proliferating microenvironment. Furthermore, it is an essential mate
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Części książek na temat "Lung Neoplasms/metabolism"

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Hjorth, Lars, Riccardo Haupt, Gisela Michel, Maria Luisa Garrè, Leontien C. M. Kremer, and Rod Skinner. "Late Effects of Therapy and Survivorship Issues." In Oxford Textbook of Cancer in Children. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198797210.003.0014.

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This chapter presents an overview of late complications of therapy for childhood cancer with a focus on organ systems at risk. First comes an introductory overview of previous and current studies on late complications of treatment for childhood cancer, followed by data on epidemiology. Serious late complications such as late mortality (i.e. premature death), second malignant neoplasms, and cardiac disease, as well as neurological and neuropsychological toxicities, are described in more detail. Endocrine problems (both gonadal and non-gonadal) are presented, including information on the metabol
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Streszczenia konferencji na temat "Lung Neoplasms/metabolism"

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Григорий Ефимович, Ройтберг, Платонова Оксана Евгеньевна, and Струтынский Владислав Андреевич. "THE FIRST CLINICAL APPLICATION EXPERIENCE IN RUSSIA PET/CT SCANNER OF THE LATEST GENERATION DISCOVERY MI GEN2 FOR THE DIAGNOSIS OF TUMOR METASTASES." In Перспективное научно-техническое развитие: тенденции, проблемы и пути совершенствования: сборник статей международной научной конференции (Санкт-Петербург, Сентябрь 2024). Crossref, 2024. http://dx.doi.org/10.58351/240924.2024.36.90.002.

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Введение. Возможность диагностики метастатического поражения (МТС) органов у пациентов со злокачественными новообразованиями с помощью позитронной эмиссионной томографии, совмещенной с компьютерной томографией (ПЭТ/КТ) во многом зависит от качества изображения, технических характеристик ПЭТ/КТ-сканнеров и использования в них современных способов цифровой обработки изображения. Цель: сравнить качество изображений и возможность выявления метастатического поражения органов при повторных ПЭТ/КТ-исследованиях на аппаратах Siemens Biograph mct 64 (Германия), GE Healthcare Discovery PET/CT 710 (США)
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