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Rozprawy doktorskie na temat „Macrovascula”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Hettema, Martha Elisabeth. "Micro- and macrovascular abnormalities in systemic sclerosis." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2008.

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ALFIERI, VALENTINA. "LOCALLY EXPRESSED MELANOCORTIN RECEPTORS MODULATE HUMAN MACROVASCULAR REMODELING." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/605171.

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Background: Vascular remodeling is a pathological process central to many cardiovascular diseases (CVDs). Vascular injury promotes a complex interplay between distinct cell populations in the vessel wall that results in endothelial dysfunction and local inflammation, which in turn stimulate vascular smooth muscle cell (SMC) proliferation and extracellular matrix (ECM) deposition, leading to neointimal thickening and stenosis. Different signaling pathways, including the melanocortin system (MCS), modulate vascular inflammation and oxidative stress. The MCS refers to a set of hormonal and paracr

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Tenório, Albuquerque Madruga Godoi Emmanuelle. "Avaliação do acontecimento macrovascular por ultra-sonografia Doppler em pacientes com esclerose sistêmica no Hospital das Clínicas da UFPE." Universidade Federal de Pernambuco, 2007. https://repositorio.ufpe.br/handle/123456789/9251.

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Made available in DSpace on 2014-06-12T23:13:47Z (GMT). No. of bitstreams: 2 arquivo8732_1.pdf: 1892416 bytes, checksum: 0b1d1d08814b0c25511ecc493774fed1 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2007<br>A Esclerose sistêmica (ES) é uma doença do tecido conjuntivo, pouco freqüente, de etiologia desconhecida, que acomete preferencialmente mulheres. Envolve múltiplos órgãos e é subdividida em dois grupos: a forma difusa, mais grave, e a limitada, denominada de CREST (Calcinose, Raynaud, hipomotilidade Esofageana, eSclerodactilia, T

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Dean, John Duncan. "Lipoprotein metabolism and macrovascular disease in non-insulin dependent diabetes mellitus." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/34322.

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A case control study comparing fasting lipid and apolipoprotein concentrations in NIDDM patients and normal control subjects matched for age, sex and body mass, reveals abnormalities of high density lipoproteins and apolipoprotein B containing lipoproteins despite hypoglycaemic therapy. HDL cholesterol concentration is reduced in these NIDDM patients, whilst apolipoprotein concentrations are similar to the controls. Therefore HDL particles may be cholesterol poor, possibly reflecting reduced reverse cholesterol transport. LDL cholesterol concentration may also be reduced in these patients whil

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Roberts, K. A. "Effects of tea on peripheral and cerebral micro- and macrovascular function in humans." Thesis, Liverpool John Moores University, 2018. http://researchonline.ljmu.ac.uk/7953/.

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Cardiovascular disease (CVD) is the leading cause of global mortality, with the incidence of cardiovascular related pathologies remaining a public health burden. CVD encompasses pathologies of the vascular tree and heart, including, for example, peripheral artery disease, coronary heart disease and ischaemic stroke. Atherosclerosis is the primary pathological process leading to CVD and is characterised by a multifactorial pathophysiology that first manifests in the vascular endothelium. Termed endothelial dysfunction, this early marker of atherosclerosis has become a focus of interest for iden

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Feinkohl, Insa. "Risk factors for cognitive decline in older people with type 2 diabetes." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9612.

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People with type 2 diabetes are at increased risk of age-related cognitive impairment. Previous literature has focused on case-control studies comparing rates of cognitive impairment in patients with and without diabetes. Investigations of potential risk factors for cognitive impairment (including those with increased prevalence in diabetes, such as macrovascular disease, and diabetes-specific factors such as hypoglycaemia) in study populations consisting exclusively of patients with type 2 diabetes have been largely neglected. Moreover, previous studies have failed to take advantage of the ex

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Chisalita, Simona I. "Expression and function of IGF-I and insulin receptors in human micro- and macrovascular cells." Doctoral thesis, Linköpings universitet, Cellbiologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-12558.

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Insulin-like growth factor and insulin are phylogenetically closely related polypeptides and have large structural and biological similarities. Low circulating insulin-like growth factor-I (IGF-I), diabetes as well as insulin resistance have been implicated in the pathogenesis of cardiovascular disease, but the mechanisms involved are still not clear. Furthermore, little is known about direct effects of insulin-like growth factor-I (IGF-I) and insulin on human micro- and macrovascular cells. In these studies we investigated the expression and function of insulin-like growth factor-I receptors

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Lo, Che Sam, and mikewood@deakin edu au. "Relationship of nutritional and metabolic factors to non-invasive, indices of macrovascular disease in diabetes." Deakin University. School of Sciences, 1986. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20051208.122550.

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Factors which may account for the high frequency of macrovascular disease in diabetics are age, sex, cigarette smoking, hypertension, obesity, lack of exercise, diet, hyperglycaemia, hyperinsulinaeroia, hypercholesterolaemia, hypertriglyceridaemia, low HDL-cholesterol concentration, elevated free fatty acid concentration and enhanced platelet aggregation. Twenty seven (13 men and 14 women) non-insulin-dependent diabetics and thirty eight age, height and weight matched healthy subjects (10 men and 28 women) were studied. None of the subjects were smokers, or hypertensive. No subject had any cli

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Rigato, Mauro. "CIRCULATING PROGENITOR CELLS: A NOVEL BIOMARKER OF MICROVASCULAR AND MACROVASCULAR DISEASE IN TYPE 2 DIABETIC PATIENTS." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3427164.

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Objective. We evaluated the ability of circulating stem cell levels to predict future micro and macrovascular complications in patients with type 2 diabetes. We further investigate the prognostic value of stem cells in a wide and heterogeneous cohort of patients, using a meta-analytic approach. Research design and methods. A cohort of 187 patients with type 2 diabetes was followed-up for a median of 3.3 years and 6.1 years for the evaluation of microvascular and macrovascular outcomes, respectively. The primary outcomes were onset or progression of any microangiopathy, and time to a first ca

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McCorquodale, Thomas Lachlan Adams. "The role of vitamin D and osteocalcin on diabetic macrovascular and microvascular events in the field study." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/11595.

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Objective People with diabetes frequently develop vascular disease, and accumulating evidence suggests a coupled interaction between bone turnover and glycaemic control. We investigated the relationship between blood 25-hydroxy vitamin D (25OH-D) and osteocalcin (OCN) concentration on vascular disease risk in type 2 diabetes. Research design and methods The relationships between blood 25OH-D and OCN concentration at baseline and the incidence of macrovascular (including myocardial infarction, stroke) and microvascular (retinopathy, nephropathy, neuropathy, and amputation) disease were analysed

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Jansson, Stefan P. O. "A Longitudinal Study of Diabetes Mellitus : With Special Reference to Incidence and Prevalence, and to Determinants of Macrovascular Complications and Mortality." Doctoral thesis, Uppsala universitet, Allmänmedicin och preventivmedicin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210916.

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Objectives. To investigate diabetes prevalence, incidence, mortality trends, the effects of hyperglycaemia and blood pressure, diabetes and hypertension treatment, and the effect of screening detection on total and cardiovascular disease (CVD), myocardial infarction (MI) and stroke incidence. Study population and methods. Between 1972 and 2001 all patients with diabetes, some detected clinically and some by case-finding procedures (screening), were entered in a diabetes register at Laxå Primary Health Care Center in Sweden. The register included information on medical treatment and laboratory

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Triches, Cristina Bergmann. "Doença macrovascular em pacientes com diabetes melito tipo 2 : aspectos do manejo clínico e avaliação de angina pectoris como fator de risco para eventos cardíacos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/27751.

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O diabetes melito (DM) é um fator de risco independente para doença arterial coronariana, acidente vascular cerebral, doença vascular periférica e insuficiência cardíaca, que são as principais causas de morte nesses pacientes. Além disso, pacientes com DM e doença cardiovascular têm pior prognóstico, por apresentarem menor sobrevida, maior risco de recorrência da doença e pior resposta aos tratamentos propostos. Os avanços diagnósticos e terapêuticos das últimas décadas já mostram uma redução do risco de eventos cardiovasculares nesses pacientes, mas o risco absoluto dos mesmos é ainda duas ve

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Montvida, Olga. "Evaluation of cardio-metabolic effects of treatment with incretin-based therapies in patients with type 2 diabetes." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122920/1/Olga_Montvida_Thesis.pdf.

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This dissertation provides a detailed exploration and valuable insights of type 2 diabetes management in the real-world setting. Incretin-based therapies and thiazolidinedione were found to provide higher chances of sustainable glycaemic and cardiovascular risk factor control, compared to older anti-diabetic treatment options. The project highlights alarming rates of the existing cardio-metabolic burden at the population level. Proper control in terms of timely intensification with anti-hyperglycaemic, anti-hypertensive, and anti-dyslipidemic therapies when needed, remains a key aspect to impr

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Singh, Dhruvaraj Kailashnath. "Clinical studies in diabetic vasculopathy to assess interactions between blood, bone and kidney." Thesis, University of Hertfordshire, 2010. http://hdl.handle.net/2299/4186.

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Diabetic vasculopathy (DV) is the most important consequence of chronic hyperglycemia in patients with diabetes mellitus (DM). This thesis explores the interaction of blood, bone and kidney in the pathogenesis of DV by i) reviewing the current understanding of pathogenesis of macrovascular and microvascular diseases in DM to identify gaps in literature and generate hypotheses relating to various facets of DV ii) undertaking a series of prospective studies to examine these hypotheses iii) analysing the findings and integrating any new information obtained from the clinical studies into the curr

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Tsao, Hsing-Sheng, and 曹新聖. "Correlation of VEGF and Macrovascular Invasion of Hepatocellular Carcinoma." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/85049307160885989540.

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碩士<br>義守大學<br>生物醫學工程學系碩士班<br>98<br>Hepatocellular carcinoma (HCC) is a hypervascular tumor. Angiogenesis and production of angiogenic factors are essential for tumor growth, invasion and metastasis. Vascular endothelial growth factor (VEGF) was a primary driving force for physiological and pathological angiogenesis and overexpression of VEGF has been observed in HCC. Macrovascular invasion (MacroVI) is a poor long-term prognosis in patients with HCC. Survival after resection for HCC with MacroVI was poorer than HCC without MacroVI. This study aims to investigate the correlation of VEGF express

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Gharakhanian, Raffi Abraham. "The role of impaired angiogenesis on perivascular adipose tissue and macrovascular function." Thesis, 2014. https://hdl.handle.net/2144/14670.

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OBJECTIVE. Only recently has hypoxia within the adipose tissue microenvironment been suggested to influence metabolic dysfunction and cardiovascular complications. Although its exact function is largely unknown, thoracic perivascular adipose tissue (PVAT) has been shown to release factors which influence vascular function. The objective of this study is to determine if vascular endothelial growth factor-A (VEGF-A) within PVAT plays a role in the maintenance of aortic structure and function. MATERIALS/METHODS. Mice with adipose-specific deficiency of VEGF were previously generated in the lab

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Carvalho, Daniela Alexandra Ferreira. "Potencial efeito terapêutico da piridoxamina na disfunção endotelial macrovascular na diabetes tipo 2." Master's thesis, 2011. http://hdl.handle.net/10316/25809.

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Dissertação de mestrado em Bioquímica, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>A diabetes tipo 2 é uma patologia complexa que apresentou uma crescente prevalência nas últimas décadas e está associada a doenças vasculares. As doenças macrovasculares representam actualmente a principal causa de mortalidade na diabetes tipo 2. A disfunção endotelial, caracterizada genericamente pela reduzida disponibilidade de óxido nítrico (NO), é uma condição que precede o desenvolvimento de lesões sintomáticas e como tal, um marca

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Song, Michael Yuming. "An ultrastructural study of macrovascular changes in rats with diabetes mellitus and hypertension." Thesis, 1992. http://hdl.handle.net/2429/3205.

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Numerous investigators have presented evidence of increased mortality in patients with diabetes mellitus due to cardiovascular disease. The reasons for a predisposition to vascular pathology that, in the advanced state, can lead to atherosclerosis are still unclear. Our hypotheses were: 1) the condition of diabetes mellitus in a streptozocin animal model may show vascular changes similar to early pathology in macrovessels, 2) since the model is normotensive, inducing hypertension will result in early atherogenic pathology, 3) the response to diabetic and/or hypertensive circumstances

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Chen, Hua-fen, and 陳華芬. "Risks of macrovascular complications among the diabetic population in Taiwan: A retrospective cohort study." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/5879gc.

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碩士<br>輔仁大學<br>公共衛生學系碩士班<br>93<br>Background and Purpose:Diabetic patients are known to have increased risks of macrovascular complications but reports on such definite risks in different age groups and on the risks associated with coronary and peripheral revascularization procedures were limited especially from a national data. By using the National Health Insurance (NHI) database of Taiwan (1997-2002), we estimated the incidence of macrovascular complications in diabetic patients and compared the risks of such complications in diabetic people with age-and sex-matched control group according t

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Chen, Chung-Yen, та 陳忠諺. "17β-oestradiol aggravates hyperglycemia-induced dysfunction of macrovascular tone regulation in ovariectomized female rats". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/14528532502821190430.

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碩士<br>國立屏東科技大學<br>生物科技系所<br>102<br>Diabetes causes vascular dysfunction. In our previous study has demonstrated that there is gender difference at the hyperglycemia-induced vascular dysfunction, it was more serious in diabetic female rats than that in diabetic male rats. Many study showed that endothelial cells is targets for estrogen. And there are some evidences showed that in some cases, estradiol (E2) have adverse effect on the blood vessels, like in post-menopausal woman, estrogen supplements increases risk of stroke and deep vein thrombosis. Therefore, we hypothesized that 17β-oestradiol

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Yen-TingChen and 陳彥廷. "Analysis of cost effectiveness on add-on oral hypoglycemic agents and diabetes related macrovascular complications." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/93565117674668194600.

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碩士<br>國立成功大學<br>臨床藥學與藥物科技研究所<br>102<br>SUMMARY We analyzed metformin based add-on oral hypoglycemic agents to identify the regimen preventing macrovascular complications in a cost effective matter. Metformin-glinides were shown to be more cost effective as compared to conventional combination of metformin- sulfonylurea. And metformin-pioglitazone also showned cost effective as compared to met-rosiglitazone. Sensitivity analysis showned length of patients being treated and patient’s disease severity may influence the cost effectiveness of each metformin based dual therapy regimens.

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Lin, Chia-Yi, and 林佳宜. "Long-term exposure to low concentration of nonylphenol exacerbates macrovascular endothelium dysfunction in male diabetic rats." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/05507995764379271186.

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碩士<br>國立屏東科技大學<br>生物科技系所<br>102<br>The contents of abstract in this thesis： Many studies showed that environmental hormones exposure causes body malformations, intersex gonads and oxidative stress in organisms. Nonylphenol (NP) is used primarily as an additive in cleaning agents, and it is one of the environmental hormones. NP is often detected in rivers and drinking water. In our previous study has demonstrated that exposure low-concentration NP is enhanced oxidative stress in rat aorta. Additionally, there are some evidences showed that exposed to NP increases oxidative stress in the pa

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Wu, Kai-Di, and 吳凱娣. "Association studies of visfatin concentration and gene polymorphism in type 2 diabetes mellitus with and without macrovascular complications." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/n6ragz.

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碩士<br>國立中山大學<br>生物科學系研究所<br>96<br>Adiposity has been shown to secrete bioactive cytokines and growth factor known as adipocytokines, they can contribute to obesity, diabetes and complications of diabetes. Visfatin is a novel adipocytokine, and it was shown to exert insulin-mimetic effects in stimulating glucose transport and induced triglyceride accumulation in preadipocytes and triglyceride synthesis from gluvose. Visfatin plasma levels are increased in morbid obesity and type 2 diabetes mellitus. These finding indicate that visfatin may play a role in the association between visceral obesity

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