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Rozprawy doktorskie na temat „Malaria”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 25 lipca 2025

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1

MacCormick, I. "Malarial retinopathy and neurovascular injury in paediatric cerebral malaria." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/2049100/.

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Background Diseases of the brain are difficult to study because this organ is relatively inaccessible. Only one part of the central nervous system is available to direct, non-invasive observation – the retina. The concept of the retina as a window to the brain has created much interest in the retina as a source of potential markers of brain disease. Paediatric cerebral malaria is a severe neurological complication of infection with the parasite Plasmodium falciparum, which is responsible for death and disability in a significant number of children in sub-Saharan Africa. As with many neurologic
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Herricks, Thurston E. "Malaria pathogenesis : deformability limits of malaria infected erythrocytes /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8622.

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Abdullah, Mohamed Rusli. "Malaria and malaria control in Jeli Peninsular Malaysia." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266047.

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Huot, Chantheany Pornthep Chanthavanich. "Clinical manifestation of uncomplicated falciparum malaria and vivax malaria in Thai children /." Abstract, 2004. http://mulinet3.li.mahidol.ac.th/thesis/2547/cd363/4638516.pdf.

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5

Melzig, Daniela. "Malaria Epidemiologie, Klinik und Verläufe bei Patienten mit importierter Malaria /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968578845.

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6

Kownatzki, Christine. "Malaria und Schwangerschaft." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-54343.

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Ohashi, Taryn M. "Eradicating Malaria: Improving a Multiple-Timestep Optimization Model of Malarial Intervention Policy." Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/scripps_theses/273.

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Malaria is a preventable and treatable blood-borne disease whose complications can be fatal. Although many interventions exist in order to reduce the impacts of malaria, the optimal method of distributing these interventions in a geographical area with limited resources must be determined. This thesis refines a model that uses an integer linear program and a compartmental model of epidemiology called an SIR model of ordinary differential equations. The objective of the model is to find an intervention strategy over multiple time steps and multiple geographic regions that minimizes the number o
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8

Owusu-Ofori, Alex. "Transfusion-transmitted malaria and bacterial infections in a malaria endemic region." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/6173/.

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Background and Methods: Blood transfusion saves lives and improves health but the presence of transfusion transmissible infections can have untoward consequences. When undetected, these infections can cause significant morbidity and mortality to transfusion recipients. On the other hand, a high prevalence of transfusion-transmitted infections (TTI) leading to rejection of a large proportion of donated blood can result in blood shortages and subsequent increase in mortality. Malaria and bacterial infections are transfusion transmissible but there is limited data concerning these infections in s
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9

Tek, F. Boray. "Computerised diagnosis of malaria." Thesis, University of Westminster, 2007. https://westminsterresearch.westminster.ac.uk/item/92068/computerised-diagnosis-of-malaria.

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10

Buitrago, Amanda Elena Maestre. "Immunity to malaria using the rodent malaria parasite Plasmodium chabaudi AS as a model of the human malaria Plasmodium falciparum." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298916.

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11

Hodgson, Susanne H. "Using the controlled human malaria infection model to investigate immunity to malaria." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:b3c9a2eb-beab-4ef6-bd8d-483390f316b8.

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Controlled human malaria infection (CHMI) studies, where healthy volunteers are infected with Plasmodium falciparum have become a vital tool to accelerate vaccine and drug development. As CHMI trials are carried out in a controlled environment, they allow unprecedented, detailed evaluation of parasite growth dynamics and immunological responses to infection. Though commonly performed in malaria-naïve populations, CHMI trials have rarely been conducted in malaria-endemic regions and to date, have not been used to investigate naturally acquired immunity (NAI) to P. falciparum infection. This th
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12

Tegha, Gerald Loiswayo. "Detection and identification of plasmodium species causing malaria in Malawi using rapid diagnostic tests." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/d1021240.

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Malaria represents one of the oldest documented diseases among humans and even today organisms in the genus Plasmodium kill more people than any other infectious disease, especially in tropical and subtropical areas. The four most common species which infect humans are Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale and Plasmodium malaria. Of these four species, Plasmodium falciparum and Plasmodium vivax account for 95 percent of infections globally. Microscopy has been used since early days for the diagnosis of malaria because this method is simple, does not require highly equipped
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13

Bernal, Acevedo Óscar Alberto. "Umbral epidémico en malaria." Doctoral thesis, Universitat Autònoma de Barcelona, 2006. http://hdl.handle.net/10803/4625.

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Este estudio analiza diferentes indicadores y propones umbrales epidémicos que pueden ayudar para una adecuada toma de decisiones. Para esto, se seleccionaron 4 epidemias en las que MSF ha intervenido en los últimos 5 años, por contar con suficiente información, en Angola, Etiopía, Tanzania y Burundi.<br/>Luego de una descripción de cada epidemia utilizando diferentes indicadores, se pudo observar que la incidencia semanal y la proporción de la malaria en la consulta externa son indicadores fáciles de recopilar, que detectan rápidamente un aumento en los casos de malaria y que sirven para ver
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14

Müller, Tara Catharina. "Non-malaria febrile illness." Diss., lmu, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-153855.

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15

Crooks, Lucy. "Gametocyte investment in malaria." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/13498.

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Gametocytes, the transmission stage of malaria parasites, are generally rare in infections. I explore whether this may be a parasite adaptation that paradoxically maximises fitness. I present an optimality analysis of gametocyte investment based on a discretely formulated within-host model. I show that low gametocyte investment is predicted as a result of the trade-off that exists between producing gametocytes and increasing parasite numbers. I predict that gametocyte investment should decrease as maximum asexual density occurs later in infections and also as parasite fecundity rises. I addres
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16

Russell, Clare. "Immunopotentiation of malaria vaccines." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/12892.

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Plasmids were constructed to encode C3d/PfEMP-1 fusions and expression of recombinant protein in mammalian cells in culture was assayed. Eukaryotic expression of <i>P. falciparum </i>proteins proved to be problematic and a re-condoning approach was adopted to address this. The production of polyclonal anti-PfEMP-1 antibodies in mice was assessed in immunofluorescence assays and in immunoblots with <i>P. falciparum</i>-infected erythrocytes. The data question the suitability of a DNA vaccine approach in the development of a PfEMP-1-based vaccine using C3d. In order to raise specific antibodies
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17

Spottiswoode, Natasha. "Hepcidin regulation in malaria." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:ea5646aa-9c64-4158-9de8-1d6b7fc9d41d.

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Epidemiological observations have linked increased host iron with malaria susceptibility. At the same time, blood-stage malaria infection is associated with potentially life-threatening anemia. To improve our understanding of these relationships, this work presents an examination of the mechanisms controlling the upregulation of the hormone hepcidin, the master regulator of iron metabolism, in malaria infection. Chapter 2 presents data from a mouse model of malaria infection which indicate that hepcidin upregulation in malaria infection is associated with increased activity of the sons of moth
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18

Павличева, Світлана Володимирівна, Светлана Владимировна Павлычева, Svitlana Volodymyrivna Pavlycheva, and O. Udoka. "Malaria epidemic in Nigeria." Thesis, Видавництво СумДУ, 2011. http://essuir.sumdu.edu.ua/handle/123456789/15950.

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The incidence of malaria is very high in Nigeria due to its tropical location. A number of factors appear to be contributing to the resurgence of malaria: rapid spread of resistance of malaria parasites to chloroquine and the other quinolines; frequent armed conflicts and civil unrest in many countries, forcing large populations to settle under difficult conditions, sometimes in areas of high malaria transmission When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/15950
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19

Soe, Soe Win Polrat Wilairatana. "Hematological changes in malaria /." Abstract, 2006. http://mulinet3.li.mahidol.ac.th/thesis/2549/cd388/4838792.pdf.

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Thematic paper (M.C.T.M. (Clinical Tropical Medicine))--Mahidol University, 2006.<br>LICL has E-Thesis 0012 ; please contact computer services. LIRV has E-Thesis 0012 ; please contact circulation services.
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20

Grieg, Rachel. "Immunopathogenesis of marine malaria." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536855.

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21

Maestre, Buitrago Amanda Elena. "Immunity to malaria using the rodent malaria parasite Plasmodium chabaudi chabaudi AS as a model of the human malaria Plasmodium falciparum." Thesis, University of Glasgow, 1997. http://theses.gla.ac.uk/2036/.

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The role of IFN in acquisition of immunity against erythrocyte forms of P.c. chabaudi AS was studied. Inbred NIH mice given the construct 7 days before malaria infection, showed a significant delay in the onset and in the level of the recrudescent parasitaemia in comparison with controls. No differences, however, were observed in the recrudescent parasitaemia between the groups. NIH mice infected with malaria 3 days after or on the same day as the administration of the IFN construct, showed a primary peak of infection similar to controls, but the resolution of this patent parasitaemia occurred
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22

Wipasa, Jiraprapa. "Induction and regulation of merozoite surface protein (MSP) 1-induced immunity to Malaria /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16496.pdf.

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23

Devenport, Martin Phillip. "Isolation and characterisation of genes regulating development in the mosquito Anopheles gambiae." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367172.

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24

Vasconcelos, Nina-Maria. "Vaccine development strategies applied to the Plasmodium falciparum malaria antigen Pf332 /." Stockholm : Wenner-Gren Institute for Experimental Biology, Stockholm university, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1263.

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25

Ghimire, Kabita. "Geographic distribution of malaria in Nepal." Diss., Kansas State University, 2016. http://hdl.handle.net/2097/34464.

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Doctor of Philosophy<br>Department of Geography<br>Douglas G. Goodin<br>The malaria burden has decreased in Nepal between 1988 and 2013. However, there are challenges to completely eradicating the disease. Malaria patterns in a few endemic districts have not changed, and higher malaria case rates have been detected within districts which otherwise were categorized as low endemic areas. Underlying biophysical, socioeconomic, and behavioral factors influence malaria transmission and create region-specific patterns. This research employs various concepts, tools, and techniques to understand the
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26

Kaneko, Akira. "Malaria on islands : human and parasite diversities and implications for malaria control in Vanuatu /." Stockholm, 1999. http://diss.kib.ki.se/1999/19990927kane.

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27

Lynch, Caroline. "The impact of migration on malaria, Southwest Uganda : malaria in the highlands of Uganda." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558361.

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28

Nisar, Samia. "Role of ATP2B4 and human malaria : looking for functional genetic variants associated with malaria." Thesis, Aix-Marseille, 2020. http://theses.univ-amu.fr.lama.univ-amu.fr/200911_NISAR_992dobfs271wcdsgy656twqjfn399ockic_TH.pdf.

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GWAS pour le paludisme grave identifié 30 variantes génétiques situées dans régions non codantes, avec seulement quelques associations répliquées dans des populations indépendantes. Dans cette étude, nous avons cherché à identifier les variantes génétiques potentielles situées dans ces loci et à démontrer leur activité fonctionnelle. Nous avons systématiquement étudié l'effet régulateur des SNP en déséquilibre liaison avec les tagSNPs associés au paludisme sévère dans plusieurs populations. L'annotation et priorisation ont conduit à l'identification d'une région régulatrice contenant 5 SNP ATP
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29

Campino, Susana. "Genetic analysis of murine malaria." Doctoral thesis, Umeå universitet, Medicinsk biovetenskap, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-124.

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Malaria, an infectious disease caused by Plasmodium parasites, is one of the major world-scale health problems. Despite the efforts aimed at finding an effective way to control the disease, the success has been thwarted by the emergence of parasite drug resistance and mosquito resistance to insecticides. This thesis focuses on the genetic analysis of resistance to murine malaria induced by the lethal Plasmodium berghei ANKA using a wild-derived-inbred strain (WDIS). The aim of this thesis was to exploit the genetic diversity represented among WDIS for identifying loci contributing to resistanc
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30

Campino, Susana Gomes. "Genetic analysis of murine malaria /." Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-124.

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31

Thiên. "Glucose metabolism in falciparum Malaria." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/74040.

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32

Crawley, Jane Margaret Stewart. "Seizures in childhood cerebral malaria." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396249.

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33

Dennison, Jeremy M. T. J. "Cytoadhesion, cytokines and cerebral malaria." Thesis, University of Liverpool, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337149.

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34

Ismail, Sabariah. "Drug conjugation pathways in malaria." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386782.

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35

Martino, Wenceslao Moreda. "Novel stains as malaria diagnostics." Thesis, University of Aberdeen, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401409.

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Chapter One highlights the importance of the control of malaria and its significance to the health of the world population.  The vital role of the diagnosis of malaria is discussed as are the advantages and disadvantages of the different diagnostic techniques. This Chapter also provides a brief introduction to the chemistry of synthetic dyes. Chapter Two reviews the mechanism of synthesis of cyanine dyes, as these are of particular importance in this research work. The characteristic properties of these dyes are discussed. Chapter Three deals with the spectroscopic properties of the dyes synth
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36

Marijani, Theresia. "Modelling drug resistance in malaria." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/4063.

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37

Mackinnon, Margaret J. "Evolutionary genetics of malaria parasites." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/15243.

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Two empirical studies on parasite virulence using the laboratory model of the rodent malaria parasite, <I>Plasmodium chabaudi,</I> in inbred mice, were conducted. In the first, the average virulence and transmissibility in eight parasite clones obtained from the wild were measured over four replicate experiments. Large amounts of genetic (between-clone) variation in virulence and transmissibility were observed. Virulence was strongly correlated, both phenotypically and genetically, to population growth rate (parasitaemia) and less strongly correlated to transmissibility. These results provide
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38

Mayer, Christina. "Structural studies of malaria proteins." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:29b4cdcb-8323-45d9-ae96-38826dd8aa56.

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Malaria is a disease of global importance, causing hundreds of thousand of deaths a year. The majority or deaths are caused by Plasmodium falciparum, a parasite transmitted by the mosquito Anopheles. Its pathogenicity largely results from an ability to transform infected erythrocytes by creating knob-like structures that result in endothelial adhesion. Two major components of these knob structures have been identified as P. falciparum erythrocyte membrane protein 1 (PfEMP1) and knob-associated histidine rich protein (KAHRP). The extracellular fragment of PfEMP1 is responsible for antigenic var
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39

Longley, Rhea Jessica. "Liver-stage vaccines for malaria." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:b5c9821c-db32-4b66-a315-02541e62f566.

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The development of an efficacious P. falciparum malaria vaccine remains a top priority. Pre-erythrocytic vaccine efforts have traditionally focussed on two well- known antigens, CSP and TRAP, yet thousands of antigens are expressed throughout the liver-stage. The work described in this thesis aimed to assess the ability of other pre-erythrocytic antigens to induce an immune response and provide protective efficacy against transgenic parasites in a mouse model. Research undertaken in our laboratory has demonstrated the ability of prime-boost viral vectored sub-unit vaccination regimens to elici
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40

Thompson, Fiona Mary. "Malaria immunology and vaccine development." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/67626/.

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This thesis describes work undertaken by the author at the University of Oxford. It begins by providing an introduction to malaria infection and pathophysiology, and a review of the latest attempts to produce an effective malaria vaccine. It goes on to describe the rationale behind the vaccines developed by the University of Oxford and others. A brief introduction to the process of planning and carrying out clinical trials of vaccines is then provided, and is followed by chapters describing two clinical trials, designed to test the safety, immunogenicity and then efficacy of candidate malaria
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41

Peery, Ashley Nicole. "Chromosomal Evolution of Malaria Vectors." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/71698.

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International malaria control initiatives such as the Roll Back Malaria Initiative (RBM) and the Medicines for Malaria Venture (MMV) mobilize resources and spur research aimed at vector control as well as the treatment and eventual eradication of the disease. These efforts have managed to reduce incidence of malaria by an estimated 37% worldwide since 2000. However, despite the promising success of control efforts such as these, the World Health Organization reports a staggering 438,000 deaths from malaria in 2015. The continuing high death toll of malaria as well as emerging insecticide and a
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42

Koka, Sai Sudha. "Suicidal erythrocyte death in malaria." [S.l. : s.n.], 2008.

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43

Rowlands, Jessica S. "Agent based modelling of Malaria." Thesis, Bangor University, 2013. https://research.bangor.ac.uk/portal/en/theses/agent-based-modelling-of-malaria(00252961-121d-463b-92e4-e08253519286).html.

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Malaria is a disease that affects millions of people each year, with 90% of deaths occurring in Africa alone. The subject of this dissertation is the agent based modelling of malaria in populations that are suffering mass migration , living in unsanitary conditions or undergoing other effects of impoverished circumstances. The research is important due to the large numbers of people affected by malaria globally, with about 3.3 billion at risk. A large proportion of those exposed to the risk live in Sub-Saharan African countries. Agent based modelling is a type of computational modelling which
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44

Bhardwaj, Inayat. "Modelling antigenic variation in malaria." Electronic Thesis or Diss., Université de Montpellier (2022-....), 2024. http://www.theses.fr/2024UMONS003.

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La gestion et l'élimination du paludisme à Plasmodium falciparum se heurte à de nombreux défis dans les zones endémiques de forte transmission. Parmi eux, la présence de nombreuses infections asymptomatiques chroniques qui servent de réservoir à des infections symptomatiques plus graves. Ce fardeau est désormais principalement concentré en Afrique subsaharienne où d’autres maladies parasitaires sont également prévalentes, parfois d’origine zoonotiques. Le réservoir caché d'infections asymptomatiques chroniques est ici la conséquence non seulement d’un taux de transmission élevé, mais aussi d’u
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45

Nordblom, Eva. "Experiences of malaria and attitudes to malaria prevention among nurses in Tanzania - An interview study." Thesis, Uppsala University, Department of Public Health and Caring Sciences, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126034.

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<p>The aim of this qualitative study was to explore experiences of malaria and attitudes to malaria prevention among nurses from Tanzania. Eleven nurses from three hospitals in northern Tanzania were interviewed. The analysis resulted in following categories: <em>The m</em><em>alaria situation was so severe at that time, Being both nurse and parent, Hindrances in the battle, Sharing knowledge </em>and<em> There is a change. </em>Ten out of eleven nurses had had malaria and all of them had been treated with anti-malarial drugs and many of them still had malaria regularly. They remembered times
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46

Saddler, Adam. "Evaluating insecticide-resistance in the malaria vector Anopheles gambiae and its implications for malaria transmission." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24434.

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Insecticide resistance, in the mosquito vector, threatens the efficacy of current methods to control malaria. Yet evidence of control failure due to insecticide resistance is sparse, despite over 50 years since resistance was identified in the mosquito. In this thesis, laboratory experiments with mosquitoes, as well as mathematical modelling, are used to improve our understanding of how insecticide resistance might impact malaria transmission. Firstly, demographic and environmental effects on the phenotypic expression of resistance are investigated. Decreasing expression of resistance with age
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47

Ashton, R. A. "Measuring low and unstable malaria transmission in Ethiopia : strategies for malaria surveillance and epidemic detection." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2014. http://researchonline.lshtm.ac.uk/2025451/.

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In Ethiopia, malaria transmission is seasonal and epidemic-prone, with both Plasmodium falciparum and Plasmodium vivax being endemic. Such spatial and temporal clustering of malaria only serves to underscore the importance of regularly collecting up-to-date malaria surveillance data to inform decision-making in malaria control and improve responsiveness to potential epidemics. This thesis compares indicators and strategies used for the monitoring and surveillance of malaria in Ethiopia. Cross-sectional school-based surveys were conducted throughout Oromia Regional State, generating data on mal
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48

Saweka, Delfina Ângela. "Factors influencing malaria care seeking behaviour in two Ghanaian communities : formal versus informal malaria care." Master's thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/9456.

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Includes bibliographical references (leaves 101-110).<br>The study primary objective was to investigate the determinants and extent of household’s reliance on the informal malaria care sector in two Ghanaians communities. The secondary objective wass to inform policy-makers and planners, especially from the public healthcare sector, on supply side issues that are likely to influence the current malaria care seeking patterns.
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49

Vittor, Amy Yomiko. "Deforestation and malaria associations between vegetation, vector ecology and malaria epidemiology in the Peruvian Amazon /." Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/3080786.

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Briët, Olivier J. T. "Towards malaria prediction in Sri Lanka : modelling spatial and temporal variability of malaria case counts /." Basel : [s.n.], 2008. http://edoc.unibas.ch/diss/DissB_8750.

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