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Rozprawy doktorskie na temat „Malignant mass”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Lagache, Laurine. "Visualizing the molecular interaction networklevel heterogeneity of malignant tumors by mass spectrometry imaging." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2024/2024ULILS111.pdf.

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Le cancer est la deuxième cause de décès dans le monde, avec 10 millions de morts et 19 millions de nouveaux cas en 2020. Le cancer du sein, le plus fréquent chez les femmes, comptait 2,26 millions de cas et près de 685 000 décès cette même année, soulignant l'urgence de recherches ciblées. Le diagnostic repose souvent sur des biopsies analysées histopathologiquement pour identifier les caractéristiques moléculaires des cellules cancéreuses. En fonction de l'expression de certains biomarqueurs (récepteurs hormonaux, oncoprotéines, récepteurs de facteurs de croissance), les sous-types de cancer

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Nygren, Yvonne. "Advances in analytical methodologies for studies of the platinum metallome in malignant cells exposed to cisplatin." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37400.

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The scientific progress about the important chemotherapeutic drug substance cisplatin (CDDP) and its function has often been rendered by data difficult to interpret, and still many questions about its mode of action remains to be clarified by the scientific community. However, studies of CDDP possess a high complexity due to; i) low intracellular concentration, ii) many potential biomolecule targets, iii) poor or unknown stability of the intact drug and its biomolecule adducts and iv) complex and varying sample matrices. Metallomic studies, using advanced analytical techniques may contribute t

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Dwivedi, Pankaj. "Phosphoproteomics analysis of normal and malignant granulocyte-colony stimulating factor receptor signaling." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1530270360628733.

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ZHANG, JIAOJIAO. "The study of malignant melanoma treatment on various platforms." Doctoral thesis, Università Politecnica delle Marche, 2021. http://hdl.handle.net/11566/291029.

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Il cancro rappresenta una delle principali cause di morte nel mondo, ma causa anche un enorme dispendio di risorse mediche. Sebbene negli ultimi anni siano stati sviluppati trattamenti innovativi come terapia genica, immunoterapia e trattamenti classici (cioè chemioterapia, radioterapia e rimozione chirurgica), ad oggi non esiste un trattamento efficace per curare questa patologia, anche perché i pazienti sviluppano spesso chemioresistenza, radioresistenza e alcuni resistono anche alla terapia genica e all'immunoterapia. La pelle è l’organo più grande del corpo umano. Il carcinoma a cellule b

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Makii, Rebecca. "Characterization of Wwox Expression and Function in Canine Mast Cell Tumors and Malignant Mast Cell Lines." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1587715457656348.

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TeÃfilo, Carolina Rodrigues. "Expression of Cd31, Cd34 and tryptase in potentially malignant lesions and squamous cell carcinoma." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8078.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Angiogenesis is the development of new blood vessels from pre-existing capillaries, being an essential step in tumor growth for supplying nutrition and oxygen to cells in proliferation. A cell that may be involved in this process is the mast cell (MC), since besides the defense function, acts in the blood vessels regulation. The MC participation in the induction of angiogenesis has been suggested in various malignant tumors. The purposes of this study was t

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Andrade, Marco Aurelio Carvalho de 1966. "Busca ativa de lesões malignas e desordens potencialmente malignas da cavidade bucal em quatro Unidades de Saúde da Família (USF) na cidade de Piracicaba." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/287866.

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Orientador: Márcio Ajudarte Lopes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-17T09:56:21Z (GMT). No. of bitstreams: 1 Andrade_MarcoAurelioCarvalhode_M.pdf: 2989445 bytes, checksum: 764bf15b465c7fc779b40cd34ebd3c1f (MD5) Previous issue date: 2010<br>Resumo: O carcinoma espinocelular (CEC) é o tumor maligno mais prevalente da cavidade bucal. Acomete principalmente homens com mais de 40 anos de idade, tabagistas e etilistas. Geralmente o diagnóstico é tardio (estádios clínicos III e IV), principalm

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Chevalier, Elodie. "Place de la signalisation Hippo dans l'histoire naturelle du Mésothéliome Pleural Malin (MPM) : dissection de ses rôles dans les lignées mésothéliales pleurales humaines et application à la caractérisation moléculaire des 448 patients atteints de MPM inclus dans l'essai clinique de phase 3 "MAPS"." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC405/document.

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Le mésothéliome pleural malin (MPM) est une tumeur primitive de la plèvre, rare, très agressive, avec un pronostic sombre. Nous avons souhaité au cours de ce travail de thèse, identifier de nouveaux biomarqueurs du MPM en testant l’influence de l’inactivation des membres de la famille RASSF/Hippo sur la survie des 448 patients inclus dans l’essai clinique MAPS (IFCT-GFPC-0701). Nous souhaitions également comprendre quelles fonctions et signalisations essentielles à l’homéostasie cellulaire, auxquelles participe la voie de signalisation RASSF/Hippo, sont perturbées lors du processus de transfor

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Filho, Júlio Cezar Marques Ricarte. "Envolvimento dos oncogenes BRAF, PIK3CA e AKT1 e do microRNA supressor de tumor let-7 na transformação maligna e progressão tumoral tiroidiana." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-06102009-094118/.

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Neste estudo, geramos ensaios de espectrometria de massa para detecção de 111 mutações nos genes RET, BRAF, NRAS, HRAS, KRAS, PIK3CA e AKT1 e avaliamos inúmeras linhagens celulares e tumores tiroidianos. Mostramos que as mutações dos genes BRAF e RAS refletem prognósticos distintos e que as mutações BRAF são altamente prevalentes em câncer metastático. Mutações dos genes PIK3CA e AKT1, esta última sendo reportada pela primeira vez no câncer de tiróide, são relativamente frequentes neste câncer. Avaliamos ainda a função do microRNA let-7 neste câncer. Mostramos que a ativação do rearranjo RET/P

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10

Kolnsberg, Laura [Verfasser], Nicolai [Akademischer Betreuer] Maass, and Klaus-Peter [Gutachter] Jünemann. "Vergleich der 25(OH)Vitamin D3 Spiegel bei benignen und malignen gynäkologischen Erkrankungen / Laura Kolnsberg ; Gutachter: Klaus-Peter Jünemann ; Betreuer: Nicolai Maass." Kiel : Universitätsbibliothek Kiel, 2020. http://d-nb.info/1233286307/34.

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Rendon, Ricardo Andres. "A PRE-OPERATIVE PREDICTIVE MODEL FOR THE CLASSIFICATION OF NEWLY DIAGNOSED RENAL MASSES LESS THAN 5 CM IN DIAMETER AS BENIGN OR MALIGNANT." 2012. http://hdl.handle.net/10222/15337.

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Objective: To develop a predictive model for preoperative differentiation between benign (B) and malignant (M) histology in patients with renal masses (RM) using recursive partitioning. Methods: We analyzed preoperative patient and tumour characteristics in 395 subjects who had surgery for RM suspicious for renal cell carcinoma. Results: The model predicted B vs. M histology with an overall accuracy of 89.6% (95% CI 86.2,92.5). It assigned patients with smaller tumours (<5.67cc) and a predominantly (>45%) exophytic component a high risk of B disease (52.6%). Patients with symptoms, larger tum

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12

Batista, Carolina Martins. "A transversalidade do vírus Epstein-Barr e suas consequências benignas e malignas mais frequentes." Master's thesis, 2020. http://hdl.handle.net/10400.6/10686.

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O vírus Epstein-Barr (EBV) é um vírus de DNA, pertencente à família gammaherpesvirus, causador de 2% dos tumores a nível mundial. Trata-se de um vírus com tropismo para células B e células epiteliais, associando-se a patologias benignas, mais frequentemente a mononucleose infeciosa (MI), a patologias malignas, como o linfoma de Burkitt (LB), o linfoma de Hodgkin (LH), o linfoma extranodal de células NK-T (LENKT)- tipo nasal, o linfoma difuso de grandes células B (LDGCB), o carcinoma nasofaríngeo (CN) e a doenças autoimunes como a esclerose múltipla (EM). A sua descoberta deu-se em 1964, num li

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13

Barbosa, Cristiana Marina de Sousa. "Abordagem cirúrgica de massas cervicais." Master's thesis, 2017. http://hdl.handle.net/10451/31190.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2017<br>Uma massa de novo a nível cervical é um problema relativamente comum em doentes ao nível dos cuidados primários. Perante uma população adulta, uma massa cervical pode ser a única manifestação de uma patologia grave e potencialmente maligna. Por outro lado, em indivíduos em idade pediátrica a maioria das massas cervicais têm duas origens essenciais, inflamatória ou congénita. Uma história clinica completa e um exame físico minucioso são essenciais, para se poderem restringir as po

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14

Soumya. "Accuracy of core needle biopsy compared to fine needle biopsy for the diagnosis of malignancy in patients with suspected head and neck cancers: A systematic review and meta-analysis of diagnostic test accuracy and comparison of adverse effects." Thesis, 2020. http://hdl.handle.net/2440/126065.

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Objective: The objective of this review was to compare the diagnostic accuracy of core needle biopsy and fine needle aspiration cytology for patients with a head and neck mass for a diagnosis of malignancy using surgical histopathology as a reference test and to compare the risks and adverse events associated with each technique. Introduction: A proportion of head and neck neoplasms are malignant which can only be determined by a tissue diagnosis. Options for tissue biopsy include - surgical biopsy, fine needle aspiration (FNA), and core needle biopsy (CNB). Insufficient tissue for a diagnosis

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Mora, Benjamin. "The Effects of Serum from Obese Patients and Adipocyte-derived Cytokines on Growth of Prostate Cancer Cells In Vitro." Thesis, 2014. http://hdl.handle.net/1807/65589.

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Obesity has been related to a greater incidence of more aggressive, advanced stage prostate cancer. It is expected that serum adipokines related to obesity will promote a more aggressive phenotype in PC cells in vitro. Patient serum (n = 80) was obtained for analysis and divided into four patient groups based on obesity and prostate cancer status. Characteristics of serum-treated PC cells in vitro were measured. In a separate set of analyses, LNCaP and PC3 cells were treated with adiponectin and resistin in vitro, and cell characteristics were analyzed. Serum from obese PC patients induces gre

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