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Artykuły w czasopismach na temat „Manipulation (Therapeutics)”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 30 lipca 2024

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1

Hao, Mengling, Jiabao Tang, Shengxiang Ge, Tingdong Li, and Ningshao Xia. "Bacterial-Artificial-Chromosome-Based Genome Editing Methods and the Applications in Herpesvirus Research." Microorganisms 11, no. 3 (February 26, 2023): 589. http://dx.doi.org/10.3390/microorganisms11030589.

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Herpesviruses are major pathogens that infect humans and animals. Manipulating the large genome is critical for exploring the function of specific genes and studying the pathogenesis of herpesviruses and developing novel anti-viral vaccines and therapeutics. Bacterial artificial chromosome (BAC) technology significantly advanced the capacity of herpesviruses researchers to manipulate the virus genomes. In the past years, advancements in BAC-based genome manipulating and screening strategies of recombinant BACs have been achieved, which has promoted the study of the herpes virus. This review su

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Almeida-Porada, Graça D. "Stem cell gene manipulation and delivery as systemic therapeutics." Advanced Drug Delivery Reviews 62, no. 12 (September 2010): 1139–40. http://dx.doi.org/10.1016/j.addr.2010.10.005.

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Juliano, Rudolph L. "Chemical Manipulation of the Endosome Trafficking Machinery: Implications for Oligonucleotide Delivery." Biomedicines 9, no. 5 (May 5, 2021): 512. http://dx.doi.org/10.3390/biomedicines9050512.

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Antisense oligonucleotides (ASOs), siRNA and splice switching oligonucleotides (SSOs) all have immense potential as therapeutic agents, potential that is now being validated as oligonucleotides enter the clinic. However, progress in oligonucleotide-based therapeutics has been limited by the difficulty in delivering these complex molecules to their sites of action in the cytosol or nucleus of cells within specific tissues. There are two aspects to the delivery problem. The first is that most types of oligonucleotides have poor uptake into non-hepatic tissues. The second is that much of the olig

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4

Wang, Ziyi, Pengchao Sun, Jingjing Su, Nan Zhang, Hongzhou Gu, and Yongxing Zhao. "DNA nanotechnology-facilitated ligand manipulation for targeted therapeutics and diagnostics." Journal of Controlled Release 340 (December 2021): 292–307. http://dx.doi.org/10.1016/j.jconrel.2021.11.004.

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Wu, Yingjie, Yining Chen, Xiaochun Yu, Minxing Zhang, and Zhaoyu Li. "Towards Understanding Neurodegenerative Diseases: Insights from Caenorhabditis elegans." International Journal of Molecular Sciences 25, no. 1 (December 28, 2023): 443. http://dx.doi.org/10.3390/ijms25010443.

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The elevated occurrence of debilitating neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Alzheimer’s disease (AD), Parkinson’s disease (PD) and Machado–Joseph disease (MJD), demands urgent disease-modifying therapeutics. Owing to the evolutionarily conserved molecular signalling pathways with mammalian species and facile genetic manipulation, the nematode Caenorhabditis elegans (C. elegans) emerges as a powerful and manipulative model system for mechanistic insights into neurodegenerative diseases. Herein, we review several representative C.

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Shanahan, Fergus. "Physiological Basis for Novel Drug Therapies Used to Treat the Inflammatory Bowel Diseases I. Pathophysiological basis and prospects for probiotic therapy in inflammatory bowel disease." American Journal of Physiology-Gastrointestinal and Liver Physiology 288, no. 3 (March 2005): G417—G421. http://dx.doi.org/10.1152/ajpgi.00421.2004.

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Mechanisms underlying the conditioning influence of the intestinal flora on mucosal homeostasis, including development and function of immune responses, are attracting increasing scientific scrutiny. The intestinal flora is a positive asset to host defense, but some of its components may, in genetically susceptible hosts, become a risk factor for development of inflammatory bowel disease (IBD). It follows that strategies to enhance assets or offset microbial liabilities represent a therapeutic option; therein lies the rationale for manipulation of the flora in IBD. In addition, the diversity o

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Papageorgiou, Maria, and Emmanuel Biver. "Interactions of the microbiome with pharmacological and non-pharmacological approaches for the management of ageing-related musculoskeletal diseases." Therapeutic Advances in Musculoskeletal Disease 13 (January 2021): 1759720X2110090. http://dx.doi.org/10.1177/1759720x211009018.

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Despite major progress in the understanding of the pathophysiology and therapeutic options for common ageing-related musculoskeletal conditions (i.e. osteoporosis and associated fractures, sarcopenia and osteoarthritis), there is still a considerable proportion of patients who respond sub optimally to available treatments or experience adverse effects. Emerging microbiome research suggests that perturbations in microbial composition, functional and metabolic capacity (i.e. dysbiosis) are associated with intestinal and extra-intestinal disorders including musculoskeletal diseases. Besides its c

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Brown, Thomas J., and Victoria James. "The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets: A Systematic Review." Cancers 13, no. 10 (May 18, 2021): 2435. http://dx.doi.org/10.3390/cancers13102435.

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Cancer stem cells (CSCs) have increasingly been shown to be a crucial element of heterogenous tumors. Although a relatively small component of the population, they increase the resistance to treatment and the likelihood of recurrence. In recent years, it has been shown, across multiple cancer types (e.g., colorectal, breast and prostate), that reciprocal communication between cancer and the microenvironment exists, which is, in part, facilitated by extracellular vesicles (EVs). However, the mechanisms of this method of communication and its influence on CSC populations is less well-understood.

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Bondhopadhyay, Banashree, Sandeep Sisodiya, Faisal Abdulrahman Alzahrani, Muhammed A. Bakhrebah, Atul Chikara, Vishakha Kasherwal, Asiya Khan, et al. "Exosomes: A Forthcoming Era of Breast Cancer Therapeutics." Cancers 13, no. 18 (September 17, 2021): 4672. http://dx.doi.org/10.3390/cancers13184672.

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Despite the recent advancements in therapeutics and personalized medicine, breast cancer remains one of the most lethal cancers among women. The prognostic and diagnostic aids mainly include assessment of tumor tissues with conventional methods towards better therapeutic strategies. However, current era of gene-based research may influence the treatment outcome particularly as an adjunct to diagnostics by exploring the role of non-invasive liquid biopsies or circulating markers. The characterization of tumor milieu for physiological fluids has been central to identifying the role of exosomes o

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10

Mahajan, Kalpesh D., Gang Ruan, Greg Vieira, Thomas Porter, Jeffrey J. Chalmers, R. Sooryakumar, and Jessica O. Winter. "Biomolecular detection, tracking, and manipulation using a magnetic nanoparticle-quantum dot platform." Journal of Materials Chemistry B 8, no. 16 (2020): 3534–41. http://dx.doi.org/10.1039/c9tb02481f.

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Fluorescent and magnetic materials play a significant role in biosensor technology, enabling sensitive quantification and separations with applications in diagnostics, purification, quality control, and therapeutics.

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11

Sweeney, Patrick, Michelle N. Bedenbaugh, Jose Maldonado, Pauline Pan, Katelyn Fowler, Savannah Y. Williams, Luis E. Gimenez, et al. "The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia." Science Translational Medicine 13, no. 590 (April 21, 2021): eabd6434. http://dx.doi.org/10.1126/scitranslmed.abd6434.

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Ablation of hypothalamic AgRP (Agouti-related protein) neurons is known to lead to fatal anorexia, whereas their activation stimulates voracious feeding and suppresses other motivational states including fear and anxiety. Despite the critical role of AgRP neurons in bidirectionally controlling feeding, there are currently no therapeutics available specifically targeting this circuitry. The melanocortin-3 receptor (MC3R) is expressed in multiple brain regions and exhibits sexual dimorphism of expression in some of those regions in both mice and humans. MC3R deletion produced multiple forms of s

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12

Yang, Cai, Haitao Zhao, Yang Sun, Cheng Wang, Xinyao Geng, Ruowen Wang, Lumin Tang, Da Han, Jianjun Liu, and Weihong Tan. "Programmable manipulation of oligonucleotide–albumin interaction for elongated circulation time." Nucleic Acids Research 50, no. 6 (March 16, 2022): 3083–95. http://dx.doi.org/10.1093/nar/gkac156.

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Abstract Oligonucleotide (ON) therapeutics are emerging as a new generation of medicine with tremendous potential, but their clinical translation is hampered by inferior stability and short circulation time in the human body. Here, we report a general approach to manipulating the interaction between ONs and albumin by modulating hydrophobicity. A series of DNA aptamer derivatives were designed and prepared by programmable synthesis as an ON library with a gradient of hydrophobic base ‘F’. In vitro experiments revealed that the introduction of two F bases at both ends of ONs enhanced the biosta

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13

Schmidt, Paul J., Iva Toudjarska, Anoop K. Sendamarai, Tim Racie, Stuart Milstein, Brian R. Bettencourt, Julia Hettinger, David Bumcrot та Mark D. Fleming. "An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe−/− mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia". Blood 121, № 7 (14 лютого 2013): 1200–1208. http://dx.doi.org/10.1182/blood-2012-09-453977.

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Key Points Tmprss6 siRNA induces hepcidin and diminishes iron in hemochromatosis or thalassemia mice, improving the anemia seen in the latter model. Manipulation of TMPRSS6 with RNAi therapeutics may be an approach to treating iron overload diseases associated with low hepcidin levels.

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14

Gilligan, Katie E., and Róisín M. Dwyer. "Extracellular Vesicles for Cancer Therapy: Impact of Host Immune Response." Cells 9, no. 1 (January 16, 2020): 224. http://dx.doi.org/10.3390/cells9010224.

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In recent times, extracellular vesicles (EVs) have come under the spotlight as potential therapeutics for cancer, due to the relative ease of manipulation of contents and potential for tumor targeting. The use of EVs as delivery vehicles may bypass some of the negative effects associated with cell-based carriers, and there has been a major focus on defining EV subtypes, establishing transparent nomenclature, and isolation and characterization techniques. EVs are believed to be a fingerprint of the secreting cell and so researchers harness the positive aspects of a particular cell of origin, an

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15

Ferreira, Catia S. M., and Sotiris Missailidis. "Aptamer-based therapeutics and their potential in radiopharmaceutical design." Brazilian Archives of Biology and Technology 50, spe (September 2007): 63–76. http://dx.doi.org/10.1590/s1516-89132007000600008.

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Aptamers, short, single stranded oligonucleotide entities, have been developed in the past 15 years against a plethora of targets and for a variety of applications. These range from inhibition of receptors and enzymes to the identification of small molecules in sensor applications, and from the development of targeted therapeutic to the design of novel diagnostic and imaging agents. Furthermore, aptamers have been designed for targets that cover a wide range of diseases, from HIV to tropical diseases, cancer and inflammation. Their easy development and flexibility of use and manipulation, offe

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16

Slaby, Ondrej, Richard Laga, and Ondrej Sedlacek. "Therapeutic targeting of non-coding RNAs in cancer." Biochemical Journal 474, no. 24 (December 14, 2017): 4219–51. http://dx.doi.org/10.1042/bcj20170079.

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The majority of the human genome encodes RNAs that do not code for proteins. These non-coding RNAs (ncRNAs) affect normal expression of the genes, including oncogenes and tumour suppressive genes, which make them a new class of targets for drug development in cancer. Although microRNAs (miRNAs) are the most studied regulatory ncRNAs to date, and miRNA-targeted therapeutics have already reached clinical development, including the mimics of the tumour suppressive miRNAs miR-34 and miR-16, which reached phase I clinical trials for the treatment of liver cancer and mesothelioma, the importance of

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Dasgupta, Ishani, and Anushila Chatterjee. "Recent Advances in miRNA Delivery Systems." Methods and Protocols 4, no. 1 (January 20, 2021): 10. http://dx.doi.org/10.3390/mps4010010.

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MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that are produced in a tissue and time-specific manner to orchestrate gene expression post-transcription. MiRNAs hybridize to target mRNA(s) to induce translation repression or mRNA degradation. Functional studies have demonstrated that miRNAs are engaged in virtually every physiological process and, consequently, miRNA dysregulations have been linked to multiple human pathologies. Thus, miRNA mimics and anti-miRNAs that restore miRNA expression or downregulate aberrantly expressed miRNAs, respectively, are high

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Wisniewski, T., D. R. Brown, and E. M. Sigurdsson. "Therapeutics in Alzheimer's and Prion Diseases." Biochemical Society Transactions 30, no. 4 (August 1, 2002): 574–78. http://dx.doi.org/10.1042/bst0300574.

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There is increasing recognition that numerous neurodegenerative conditions have the same underlying pathogenetic mechanism, namely a change in protein conformation, where the β-sheet content is increased. In Alzheimer's disease, amyloid deposition in the form of neuritic plaques and congophilic angiopathy is driven by the conversion of normal soluble amyloid-β peptide (sAβ) to Aβ plaques; while in the prionoses the critical event is the conversion of normal prion protein, PrPc, to the disease-associated form, PrPsc. This common theme in the pathogenesis of these disorders and the extracellular

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Serge Andigema, Angyiba. "Viral Hijacking of Host RNA-binding Proteins: Implications for Viral Replication and Pathogenesis." Journal of Clinical and Laboratory Research 7, no. 5 (May 31, 2024): 01–06. http://dx.doi.org/10.31579/2768-0487/136.

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In the intricate dance between viruses and host cells, RNA-binding proteins (RBPs) serve as crucial orchestrators of gene expression and cellular processes. We will delve into the riveting realm of viral hijacking, where viruses deftly exploit host RBPs to manipulate cellular machinery for their replication and pathogenesis. Through a masterstroke of molecular subterfuge, viruses co-opt RBPs involved in various facets of RNA metabolism - from transcription to degradation - to promote viral gene expression and evade host immune defenses. This manipulation leads to global alterations in cellular

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20

Zha, Jun, Jinjing Li, Shihui Fan, Zengping Duan, Yibing Zhao, and Chuanliu Wu. "An evolution-inspired strategy to design disulfide-rich peptides tolerant to extensive sequence manipulation." Chemical Science 12, no. 34 (2021): 11464–72. http://dx.doi.org/10.1039/d1sc02952e.

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A general method was developed to design multicyclic peptides with diverse disulfide frameworks amenable to random peptide library design, enabling the development of new disulfide-rich peptide ligands and therapeutics with structures not derived from natural peptides.

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Shinde, Pallavi, Loganathan Mohan, Amogh Kumar, Koyel Dey, Anjali Maddi, Alexander Patananan, Fan-Gang Tseng, Hwan-You Chang, Moeto Nagai, and Tuhin Santra. "Current Trends of Microfluidic Single-Cell Technologies." International Journal of Molecular Sciences 19, no. 10 (October 12, 2018): 3143. http://dx.doi.org/10.3390/ijms19103143.

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The investigation of human disease mechanisms is difficult due to the heterogeneity in gene expression and the physiological state of cells in a given population. In comparison to bulk cell measurements, single-cell measurement technologies can provide a better understanding of the interactions among molecules, organelles, cells, and the microenvironment, which can aid in the development of therapeutics and diagnostic tools. In recent years, single-cell technologies have become increasingly robust and accessible, although limitations exist. In this review, we describe the recent advances in si

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Yamamoto, Tsuyoshi, and Asako Yamayoshi. "Physicochemical Manipulation for Effective Nucleic Acid Therapeutics -Toward Material Symbiosis with Nucleic Acid Drugs-." Drug Delivery System 37, no. 2 (March 25, 2022): 131–41. http://dx.doi.org/10.2745/dds.37.131.

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Rani, Vibha, Shivani Singhal, Kumkum Sharma, Rohan Vaid, Kanishka Aggarwal, Renu Bhadana, Radhika Agarwal, and Neha Atale. "Human Gut Microbiome: A New Frontier in Cancer Diagnostics & Therapeutics." Current Pharmaceutical Design 27, no. 45 (November 19, 2021): 4578–92. http://dx.doi.org/10.2174/1381612827666211006152112.

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The field of oncology is vast and ever-growing. The present cancer therapeutics is continually exhibiting various drawbacks, which opens the door for exploring better novel therapeutic techniques. One such emerging technique is the manipulation of gut microbiota to induce a positive curative effect in the body. The dynamic gut microbiota of our body houses an astonishing number of microorganisms, mainly bacteria. The balance of the gut microbiota is essential for good health as imbalances may result in dysbiosis leading to various diseases such as cancer. The gut microbiota can be manipulated

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Duong, Mai Thi-Quynh, Yeshan Qin, Sung-Hwan You, and Jung-Joon Min. "Bacteria-cancer interactions: bacteria-based cancer therapy." Experimental & Molecular Medicine 51, no. 12 (December 2019): 1–15. http://dx.doi.org/10.1038/s12276-019-0297-0.

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AbstractRecent advances in cancer therapeutics, such as targeted therapy and immunotherapy, have raised the hope for cures for many cancer types. However, there are still ongoing challenges to the pursuit of novel therapeutic approaches, including high toxicity to normal tissue and cells, difficulties in treating deep tumor tissue, and the possibility of drug resistance in tumor cells. The use of live tumor-targeting bacteria provides a unique therapeutic option that meets these challenges. Compared with most other therapeutics, tumor-targeting bacteria have versatile capabilities for suppress

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Zheng, Mingjie, Joan Jacob, Shao-Hsi Hung, and Jun Wang. "The Hippo Pathway in Cardiac Regeneration and Homeostasis: New Perspectives for Cell-Free Therapy in the Injured Heart." Biomolecules 10, no. 7 (July 10, 2020): 1024. http://dx.doi.org/10.3390/biom10071024.

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Intractable cardiovascular diseases are leading causes of mortality around the world. Adult mammalian hearts have poor regenerative capacity and are not capable of self-repair after injury. Recent studies of cell-free therapeutics such as those designed to stimulate endogenous cardiac regeneration have uncovered new feasible therapeutic avenues for cardiac repair. The Hippo pathway, a fundamental pathway with pivotal roles in cell proliferation, survival and differentiation, has tremendous potential for therapeutic manipulation in cardiac regeneration. In this review, we summarize the most rec

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Teo, Min Yuen, Dana E. Rathkopf, and Philip Kantoff. "Treatment of Advanced Prostate Cancer." Annual Review of Medicine 70, no. 1 (January 27, 2019): 479–99. http://dx.doi.org/10.1146/annurev-med-051517-011947.

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The therapeutic landscape of prostate cancer has been transformed over the last decade by new therapeutics, advanced functional imaging, next-generation sequencing, and better use of existing therapies in early-stage disease. Until 2004, progression on androgen deprivation therapy for metastatic disease was treated with the addition of secondary hormonal manipulation; in the last decade, six systemic agents have been approved for the treatment of castration-resistant prostate cancer. We review clinical trials and survival benefit for these therapies and assess how the understanding of the dise

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Poirot, Laurent, Cécile Schiffer-Mannioui, Brian Philip, Sophie Derniame, Agnes Gouble, Isabelle Chion-Sotinel, Diane Le Clerre, et al. "T-Cell Engineering For “off-The-shelf” Adoptive Immunotherapy." Blood 122, no. 21 (November 15, 2013): 1661. http://dx.doi.org/10.1182/blood.v122.21.1661.1661.

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Abstract Adoptive T-cell therapies, where exogenous expression of a chimeric antigen receptor (CAR) confers cancer recognition, have shown significant promise in initial clinical trials. However, present adoptive immunotherapy Methods are limited by the need for manipulation of autologous patient T-cells. To permit such an approach in an allogeneic context, Transcription Activator-Like Effector Nucleases (TALENTM) have been used to simultaneously inactivate the endogenous T cell receptor and CD52, a cellular target for a lymphodepleting treatment. This approach reduces the risk of GVHD while p

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Yagi, Yusuke, Takamasa Teramoto, Shuji Kaieda, Takayoshi Imai, Tadamasa Sasaki, Maiko Yagi, Nana Maekawa, and Takahiro Nakamura. "Construction of A Versatile, Programmable RNA-binding Protein using Designer PPR Proteins and Its Application for Splicing Control in Mammalian Cells." Cells 11, no. 22 (November 8, 2022): 3529. http://dx.doi.org/10.3390/cells11223529.

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RNAs play many essential roles in gene expression and are involved in various human diseases. Although genome editing technologies have been established, the engineering of sequence-specific RNA-binding proteins that manipulate particular cellular RNA molecules is immature, in contrast to nucleotide-based RNA manipulation technology, such as siRNA- and RNA-targeting CRISPR/Cas. Here, we demonstrate a versatile RNA manipulation technology using pentatricopeptide-repeat (PPR)-motif-containing proteins. First, we developed a rapid construction and evaluation method for PPR-based designer sequence

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Nguyen, Thuy, Brian F. Thomas, and Yanan Zhang. "Overcoming the Psychiatric Side Effects of the Cannabinoid CB1 Receptor Antagonists: Current Approaches for Therapeutics Development." Current Topics in Medicinal Chemistry 19, no. 16 (September 16, 2019): 1418–35. http://dx.doi.org/10.2174/1568026619666190708164841.

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The Cannabinoid CB1 Receptor (CB1R) is involved in a variety of physiological pathways and has long been considered a golden target for therapeutic manipulation. A large body of evidence in both animal and human studies suggests that CB1R antagonism is highly effective for the treatment of obesity, metabolic disorders and drug addiction. However, the first-in-class CB1R antagonist/inverse agonist, rimonabant, though demonstrating effectiveness for obesity treatment and smoking cessation, displays serious psychiatric side effects, including anxiety, depression and even suicidal ideation, result

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Dodson, Matthew, Montserrat Rojo de la Vega, Aram B. Cholanians, Cody J. Schmidlin, Eli Chapman, and Donna D. Zhang. "Modulating NRF2 in Disease: Timing Is Everything." Annual Review of Pharmacology and Toxicology 59, no. 1 (January 6, 2019): 555–75. http://dx.doi.org/10.1146/annurev-pharmtox-010818-021856.

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The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central regulator of redox, metabolic, and protein homeostasis that intersects with many other signaling cascades. Although the understanding of the complex nature of NRF2 signaling continues to grow, there is only one therapeutic targeting NRF2 for clinical use, dimethyl fumarate, used for the treatment of multiple sclerosis. The discovery of new therapies is confounded by the fact that NRF2 levels vary significantly depending on physiological and pathological context. Thus, properly timed and targeted ma

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Kao, Ting-Wei, and Chin-Chou Huang. "Inflammatory Burden and Immunomodulative Therapeutics of Cardiovascular Diseases." International Journal of Molecular Sciences 23, no. 2 (January 12, 2022): 804. http://dx.doi.org/10.3390/ijms23020804.

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Phenotyping cardiovascular illness and recognising heterogeneities within are pivotal in the contemporary era. Besides traditional risk factors, accumulated evidence suggested that a high inflammatory burden has emerged as a key characteristic modulating both the pathogenesis and progression of cardiovascular diseases, inclusive of atherosclerosis and myocardial infarction. To mechanistically elucidate the correlation, signalling pathways downstream to Toll-like receptors, nucleotide oligomerisation domain-like receptors, interleukins, tumour necrosis factor, and corresponding cytokines were r

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Fujiwara, Yusuke, Yuki Yamanashi, Akiko Fujimura, Yuko Sato, Tomoya Kujirai, Hitoshi Kurumizaka, Hiroshi Kimura, Kenzo Yamatsugu, Shigehiro A. Kawashima, and Motomu Kanai. "Live-cell epigenome manipulation by synthetic histone acetylation catalyst system." Proceedings of the National Academy of Sciences 118, no. 4 (January 19, 2021): e2019554118. http://dx.doi.org/10.1073/pnas.2019554118.

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Chemical modifications of histones, such as lysine acetylation and ubiquitination, play pivotal roles in epigenetic regulation of gene expression. Methods to alter the epigenome thus hold promise as tools for elucidating epigenetic mechanisms and as therapeutics. However, an entirely chemical method to introduce histone modifications in living cells without genetic manipulation is unprecedented. Here, we developed a chemical catalyst, PEG-LANA-DSSMe 11, that binds with nucleosome’s acidic patch and promotes regioselective, synthetic histone acetylation at H2BK120 in living cells. The size of p

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Mathew, Robins, Robert McGee, Kevin Roche, Shada Warreth, and Nikolaos Papakostas. "Introducing Mobile Collaborative Robots into Bioprocessing Environments: Personalised Drug Manufacturing and Environmental Monitoring." Applied Sciences 12, no. 21 (October 27, 2022): 10895. http://dx.doi.org/10.3390/app122110895.

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Personalised therapeutic drugs are the future of the medical drug sector. For manufacturers, this will require the flexibility to produce many different unique batches within a given facility. This research paper aims to demonstrate the potential of mobile collaborative robots for improving current manufacturing practices in personalised therapeutics. The benefits and challenges of introducing robots in biologics are explored, including current practices, limitations, likely future practices, and the market outlook. Experiments demonstrating the application of a mobile collaborative robot to p

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Winter, Ann, Lois A. Salamonsen, and Jemma Evans. "Modelling fibroid pathology: development and manipulation of a myometrial smooth muscle cell macromolecular crowding model to alter extracellular matrix deposition." Molecular Human Reproduction 26, no. 7 (May 25, 2020): 498–509. http://dx.doi.org/10.1093/molehr/gaaa036.

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ABSTRACT Current treatment options for uterine fibroids are limited to hormonal manipulation or surgical intervention. We aimed to develop an in vitro model to mirror collagen deposition and extracellular matrix (ECM) formation, the principal features of uterine fibroids, to enable testing of novel therapeutics. Macromolecular crowding with Ficoll 400 and Ficoll 70 in cultures of human uterine myometrial smooth muscle cells containing ascorbic acid, provided the basis for this model. These culture conditions mimic the ‘crowded’ nature of the in vivo extracellular environment by incorporating n

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Filippou, Charalampos, Sophia C. Themistocleous, Giorgos Marangos, Yiannis Panayiotou, Maria Fyrilla, Christina A. Kousparou, Zoi-Dorothea Pana, Constantinos Tsioutis, Elizabeth O. Johnson, and Andreas Yiallouris. "Microbial Therapy and Breast Cancer Management: Exploring Mechanisms, Clinical Efficacy, and Integration within the One Health Approach." International Journal of Molecular Sciences 25, no. 2 (January 16, 2024): 1110. http://dx.doi.org/10.3390/ijms25021110.

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This comprehensive review elucidates the profound relationship between the human microbiome and breast cancer management. Recent findings highlight the significance of microbial alterations in tissue, such as the gut and the breast, and their role in influencing the breast cancer risk, development, progression, and treatment outcomes. We delve into how the gut microbiome can modulate systemic inflammatory responses and estrogen levels, thereby impacting cancer initiation and therapeutic drug efficacy. Furthermore, we explore the unique microbial diversity within breast tissue, indicating poten

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Allen, Ashley B., Josh A. Zimmermann, Olivia A. Burnsed, Doron Cohn Yakubovich, Hazel Y. Stevens, Zulma Gazit, Todd C. McDevitt, and Robert E. Guldberg. "Environmental manipulation to promote stem cell survival in vivo: use of aggregation, oxygen carrier, and BMP-2 co-delivery strategies." Journal of Materials Chemistry B 4, no. 20 (2016): 3594–607. http://dx.doi.org/10.1039/c5tb02471d.

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While mesenchymal stem cell (MSC)-based strategies for critically-sized bone defect repair hold promise, poor cell survival in vivo remains a significant barrier to the translation of these therapeutics.

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Gilham, Dean, Audrey L. Smith, Li Fu, Dalia Y. Moore, Abenaya Muralidharan, St Patrick M. Reid, Stephanie C. Stotz, et al. "Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro." Biomedicines 9, no. 4 (April 18, 2021): 437. http://dx.doi.org/10.3390/biomedicines9040437.

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Effective therapeutics are urgently needed to counter infection and improve outcomes for patients suffering from COVID-19 and to combat this pandemic. Manipulation of epigenetic machinery to influence viral infectivity of host cells is a relatively unexplored area. The bromodomain and extraterminal (BET) family of epigenetic readers have been reported to modulate SARS-CoV-2 infection. Herein, we demonstrate apabetalone, the most clinical advanced BET inhibitor, downregulates expression of cell surface receptors involved in SARS-CoV-2 entry, including angiotensin-converting enzyme 2 (ACE2) and

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Wang, Julie, Junlong Dang, and Song Guo Zheng. "Human gingiva-derived mesenchymal stem cells are therapeutic in lupus nephritis through targeting of CD39-CD73 signaling pathway." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 236.13. http://dx.doi.org/10.4049/jimmunol.204.supp.236.13.

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Abstract Cell specific and cytokine targeted therapeutics have underperformed in systemic lupus erythematosus (SLE). Mesenchymal stem cells (MSCs) have emerged as a novel therapy to address the dysregulation in autoimmune diseases but also have limitations. Human gingiva derived MSCs (GMSCs) are superior in regulating immune responses. Here, we demonstrate that the adoptively transferred GMSC home to and maintain in the kidney and have a robust therapeutic effect in a spontaneous lupus nephritis model. Specifically, GMSCs limits the development of autoantibodies as well as proteinuria, decreas

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Pacheco, David Rincon Fernandez, Hannah Park, Katie Grausam, and Joshua Breunig. "NGMA-4. Creation of a MADR brain tumor single-cell atlas for examination of inter-/intratumor heterogeneity and the results of genetic perturbations in a diverse array of brain tumor subtypes." Neuro-Oncology Advances 3, Supplement_2 (July 1, 2021): ii5. http://dx.doi.org/10.1093/noajnl/vdab070.019.

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Abstract We have recently established mosaic analysis by dual recombinase-mediated cassette exchange (MADR), which permits stable labeling of mutant cells expressing transgenic elements from precisely defined chromosomal loci. MADR provides a toolkit of elements for combinatorial labeling, inducible/reversible transgene manipulation, VCre recombinase expression, and genetic manipulation of human cells. Further, we have demonstrated the versatility of MADR by creating glioma models with mixed, reporter-identified zygosity or with “personalized” driver mutations from pediatric glioma. For exampl

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Hashizume, Atsushi, Kenneth H. Fischbeck, Maria Pennuto, Pietro Fratta, and Masahisa Katsuno. "Disease mechanism, biomarker and therapeutics for spinal and bulbar muscular atrophy (SBMA)." Journal of Neurology, Neurosurgery & Psychiatry 91, no. 10 (September 15, 2020): 1085–91. http://dx.doi.org/10.1136/jnnp-2020-322949.

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Spinal and bulbar muscular atrophy (SBMA) is a hereditary neuromuscular disorder caused by CAG trinucleotide expansion in the gene encoding the androgen receptor (AR). In the central nervous system, lower motor neurons are selectively affected, whereas pathology of patients and animal models also indicates involvement of skeletal muscle including loss of fast-twitch type 2 fibres and increased slow-twitch type 1 fibres, together with a glycolytic-to-oxidative metabolic switch. Evaluation of muscle and fat using MRI, in addition to biochemical indices such as serum creatinine level, are promisi

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Campbell, Jarryd M., Katherine A. Hartjes, Timothy J. Nelson, Xiaolei Xu, and Stephen C. Ekker. "New and TALENted Genome Engineering Toolbox." Circulation Research 113, no. 5 (August 16, 2013): 571–87. http://dx.doi.org/10.1161/circresaha.113.301765.

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Recent advances in the burgeoning field of genome engineering are accelerating the realization of personalized therapeutics for cardiovascular disease. In the postgenomic era, sequence-specific gene-editing tools enable the functional analysis of genetic alterations implicated in disease. In partnership with high-throughput model systems, efficient gene manipulation provides an increasingly powerful toolkit to study phenotypes associated with patient-specific genetic defects. Herein, this review emphasizes the latest developments in genome engineering and how applications within the field are

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Guru Murthy, Guru Subramanian, Brent R. Logan, Stephanie Bo-Subait, Amer Beitingjaneh, Steven Devine, Nosha Farhadfar, Lohith Gowda, et al. "Major ABO Incompatibility Significantly Influences the Survival and Outcomes after Allogeneic Hematopoietic Cell Transplantation in Leukemia - CIBMTR Analysis." Blood 138, Supplement 1 (November 5, 2021): 907. http://dx.doi.org/10.1182/blood-2021-150635.

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Abstract Background: Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). While many factors influence the outcomes of allo-HCT in these leukemias, the independent impact of ABO mismatching between the patient and donor remains unclear. Methods: Using the CIBMTR database, we identified adults aged ≥18 years with AML or ALL who underwent allo-HCT from HLA-matched sibling donor (MSD) or 8/8 matched unrelated donor (MUD) between 2008-2018. We excluded patients who underwent transplant

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He, Buyuan, James T. Tran, and David Jesse Sanchez. "Manipulation of Type I Interferon Signaling by HIV and AIDS-Associated Viruses." Journal of Immunology Research 2019 (April 4, 2019): 1–10. http://dx.doi.org/10.1155/2019/8685312.

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Type I Interferons were first described for their profound antiviral abilities in cell culture and animal models, and later, they were translated into potent antiviral therapeutics. However, as additional studies into the function of Type I Interferons progressed, it was also seen that pathogenic viruses have coevolved to encode potent mechanisms allowing them to evade or suppress the impact of Type I Interferons on their replication. For chronic viral infections, such as HIV and many of the AIDS-associated viruses, including HTLV, HCV, KSHV, and EBV, the clinical efficacy of Type I Interferon

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Köhler, Cristiano A., André F. Carvalho, Gilberto S. Alves, Roger S. McIntyre, Thomas N. Hyphantis, and Martín Cammarota. "Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target?" Neural Plasticity 2015 (2015): 1–14. http://dx.doi.org/10.1155/2015/759139.

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Major depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories. We review the following core domains of deficit: systematic biases favoring materials of negative emotional valence; diminished access and response to positive memories; a recollection of overgeneral memories in detriment of specific autobiographical memories; and the role of ruminative processes and avoidance when dealing with autobiographical memories. Furthermore, we review evidence from functional neuroimaging studies of neural circuits activated by the recollection of autobiographi

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Zhang, Peiran, Hunter Bachman, Adem Ozcelik, and Tony Jun Huang. "Acoustic Microfluidics." Annual Review of Analytical Chemistry 13, no. 1 (June 12, 2020): 17–43. http://dx.doi.org/10.1146/annurev-anchem-090919-102205.

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Acoustic microfluidic devices are powerful tools that use sound waves to manipulate micro- or nanoscale objects or fluids in analytical chemistry and biomedicine. Their simple device designs, biocompatible and contactless operation, and label-free nature are all characteristics that make acoustic microfluidic devices ideal platforms for fundamental research, diagnostics, and therapeutics. Herein, we summarize the physical principles underlying acoustic microfluidics and review their applications, with particular emphasis on the manipulation of macromolecules, cells, particles, model organisms,

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Park, Shin Young, Sang Pyung Lee, Dongin Kim, and Woo Jin Kim. "Gut Dysbiosis: A New Avenue for Stroke Prevention and Therapeutics." Biomedicines 11, no. 9 (August 23, 2023): 2352. http://dx.doi.org/10.3390/biomedicines11092352.

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A stroke is a serious life-threatening condition and a leading cause of death and disability that happens when the blood vessels to part of the brain are blocked or burst. While major advances in the understanding of the ischemic cascade in stroke was made over several decades, limited therapeutic options and high mortality and disability have caused researchers to extend the focus toward peripheral changes beyond brain. The largest proportion of microbes in human body reside in the gut and the interaction between host and microbiota in health and disease is well known. Our study aimed to expl

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Shin, Yuseon, Patihul Husni, Kioh Kang, Dayoon Lee, Sehwa Lee, Eunseong Lee, Yuseok Youn, and Kyungtaek Oh. "Recent Advances in pH- or/and Photo-Responsive Nanovehicles." Pharmaceutics 13, no. 5 (May 14, 2021): 725. http://dx.doi.org/10.3390/pharmaceutics13050725.

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The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumo

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Wu, Kuo-Jen, Seongjin Yu, Jea-Young Lee, Barry Hoffer, and Yun Wang. "Improving Neurorepair in Stroke Brain Through Endogenous Neurogenesis-Enhancing Drugs." Cell Transplantation 26, no. 9 (September 2017): 1596–600. http://dx.doi.org/10.1177/0963689717721230.

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Stroke induces not only cell death but also neurorepair. De novo neurogenesis has been found in the subventricular zone of the adult mammalian brain days after stroke. Most of these newly generated cells die shortly after the insult. Recent studies have shown that pharmacological manipulation can improve the survival of endogenous neuroprogenitor cells and neural regeneration in stroke rats. As these drugs target the endogenous reparative processes that occur days after stroke, they may provide a prolonged window for stroke therapy. Here, we discuss endogenous neurogenesis-enhancing drugs and

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Yang, Ji Won, Yoojin Seo, Tae-Hoon Shin, Ji-Su Ahn, Su-Jeong Oh, Ye Young Shin, Min-Jung Kang, et al. "Extracellular Vesicles from SOD3-Transduced Stem Cells Exhibit Improved Immunomodulatory Abilities in the Murine Dermatitis Model." Antioxidants 9, no. 11 (November 23, 2020): 1165. http://dx.doi.org/10.3390/antiox9111165.

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The immunoregulatory abilities of mesenchymal stem cells (MSCs) have been investigated in various autoimmune and allergic diseases. However, the therapeutic benefits observed in preclinical settings have not been reproducible in clinical trials. This discrepancy is due to insufficient efficacy of MSCs in harsh microenvironments, as well as batch-dependent variability in potency. Therefore, to achieve more beneficial and uniform outcomes, novel strategies are required to potentiate the therapeutic effect of MSCs. One of simple strategies to augment cellular function is genetic manipulation. Sev

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Alberti, Michael, Jessy Deshane, Larisa Pereboeva, Yuko Tsuruta, Ed Abraham, David Chaplin, Stanton Gerson, David Curiel, and Justin Roth. "A recombinant adenovirus for targeted gene therapy of pulmonary inflammation (155.23)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 155.23. http://dx.doi.org/10.4049/jimmunol.186.supp.155.23.

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Abstract Inflammation is a pathological component of many debilitating lung diseases. Thus, therapeutics that suppress the inflammatory response should also minimize inflammation-induced airway destruction. In this regard, Adenovirus type 5 (Ad5) vectors have a long history as therapeutic agents, due to their in vivo stability and amenability to genetic manipulation. Since circulating leukocytes infiltrate and mediate damage to the sites of pathology, we proposed to modulate Ad5 tropism to the dense leukocyte pool in the lung microvasculature for localized therapeutic intervention of inflammat

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