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Rozprawy doktorskie na temat „Mdr of mycobacterium tuberculosis”

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Data publikacji: 3 czerwca 2025
Data aktualizacji: 31 lipca 2025

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Bonnet, Isabelle. "Rôle de whiB6 et kdpDE dans le clone MDR hypertransmissible B0/W148 de Mycobacterium tuberculosi." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS478.pdf.

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La tuberculose (TB) est, hors COVID, la première cause de décès lié à un agent infectieux. La détermination rapide du profil de résistance complet de Mycobacterium tuberculosis (Mtb) est essentielle pour démarrer un traitement adapté dans les cas de TB multirésistante (MDR) et ainsi limiter l’acquisition de résistances supplémentaires, augmenter les chances de succès thérapeutique et réduire la transmission de ces souches. Il existe 9 lignées principales au sein du complexe M. tuberculosis, dont 2 sont largement répandues dans le monde (L2 et L4). Au sein de la lignée 2, le clone W148 (ou comp
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SHARMA, KRITIKA. "TO DECIPHERTHE ROLE OF TA SYSTEMS IN MYCOBACTERIUM TUBERCULOSIS." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18461.

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Mycobacterium tuberculosis is the bacteria responsible for the disease of the infamous Tuberculosis (TB). mtb is the major human pathogens prevalent in developing countries, with an appropriate number of 2 million deaths per year. This disease is treatable but the hurdles we face, this project helps in giving the new approach and better perspective. Latent Tb is the phase when the bacteria exits in one person’s body and unable to replicate properly due to healthy and good immunity response. But it shows its pathogenicity when the immune response gets degraded. The reason can be any othe
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Tarazona, Jurado David Demetrio. "Análisis genómico de Mycobacterium tuberculosis sensible, MDR y XDR aislados en el Perú." Master's thesis, Universidad Nacional Mayor de San Marcos, 2019. https://hdl.handle.net/20.500.12672/11597.

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Señala que la tuberculosis (TB) es una de las enfermedades más importantes en salud pública en el mundo y en el Perú tiene una notable importancia por el número de casos de TB registrados y el incremento de casos drogorresistentes en los últimos años. Se realizó el análisis genómico comparativo de tres genomas de Mycobacterium tuberculosis que mostraban características fenotípicas de sensibilidad a drogas (INS-SEN), multidrogorresistente (INS-MDR) y extremadamente resistente (INSXDR). Se determinó que los aislados de INS-MDR y de INS-XDR difieren en 6.1% SNPs, mientras que el análisis comparat
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SANTOS, Lorena Cristina. "Análise de resistência a antimicrobianos de cepas de Mycobacterium tuberculosis isoladas no Estado de Goiás." Universidade Federal de Goiás, 2010. http://repositorio.bc.ufg.br/tede/handle/tde/1567.

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Made available in DSpace on 2014-07-29T15:26:20Z (GMT). No. of bitstreams: 1 TeseLorenaCristina2010.pdf: 1826396 bytes, checksum: fc176dacea640559fe92237b2a050e60 (MD5) Previous issue date: 2010-12-07<br>Tuberculosis (TB) is a serious global public health. In Brazil for the confirmed TB cases is recommended a multi-drug therapy regimen which combines different drugs during at least 6 month. However, because of treatment inconsistency, the emergency and spread of drug resistant M. tuberculosis become a serious threat. Actually, strains resistant to at least one drug used in the TB treatment h
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Stoffels, Karolien. "Contribution to the research on drug resistant Mycobacterium tuberculosis." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209194.

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Tuberculosis (TB) is a potentially fatal contagious disease that can affect almost any part of the body but is mainly an infection of the lungs. It is caused by micro-organisms of the Mycobacterium tuberculosis complex. It is the second greatest killer worldwide due to a single infectious agent, after the Human Immunodeficiency Virus (HIV). Without treatment, fatality is 50% in immune competent persons. TB remains the leading cause of death among HIV positive persons, causing one fifth of the deaths. The World Health Organization estimates that one third of the world population is infected by
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Souza, Márcia Alves de. "Avaliação do desempenho da PCR Multiplex alelo específico para detecção de genes de Mycobacterium tuberculosis associados à resistência a Rifampicina e Isoniazida, a partir de amostra clínica." Universidade Federal do Amazonas, 2013. http://tede.ufam.edu.br/handle/tede/2565.

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Made available in DSpace on 2015-04-11T13:54:24Z (GMT). No. of bitstreams: 1 Marcia Alves de Souza.pdf: 1923965 bytes, checksum: 3ad1484efad384495579203b0e85259c (MD5) Previous issue date: 2013-05-30<br>FAPEAM - Fundação de Amparo à Pesquisa do Estado do Amazonas<br>A Tuberculose (TB) é uma doença infecciosa causada pelo complexo Mycobacterium tuberculosis, sendo considerada um grave problema de saúde pública mundial. Atualmente, isolados de M. tuberculosis resistentes a pelo menos um medicamento utilizado no tratamento da TB tem sido documentados em todos os países. De acordo com a Organi
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Willemse, Danicke. "Regulation of efflux in rifampicin resistant mutants of Mycobacterium tuberculosis." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/79820.

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Thesis (MScMedSc)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Multidrug resistant tuberculosis (MDR-TB), defined as having resistance to at least the first-line drugs, isoniazid and rifampicin (RIF), is a global health problem. Mutations in the rpoB gene, encoding the β-subunit of RNA polymerase, are implicated in RIF resistance - with the S531L and H526Y mutations occurring most frequently. The level of RIF resistance varies for strains with identical rpoB mutations, which suggests that other factors play a role in RIF resistance. Efflux has been implicated in determining the intrins
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Klotoe, Jésutondin Bernice Mélaine. "Développement de méthodes pour le diagnostic, le contrôle, la surveillance de la tuberculose à bacilles ultra-résistants et des souches épidémiques Beijing." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS379/document.

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La tuberculose MDR/XDR (multi et ultrarésistante aux antituberculeux) causée par Mycobacterium tuberculosis constitue un problème de santé publique mondial. L’étude et l’identification des mutations responsables de la résistance sont des facteurs clés pour le contrôle et la surveillance de la tuberculose MDR/XDR. L’expansion de lignée L2/Beijing, une famille de souches originaire du Sud-Est de la Chine (Guangxi) potentiellement plus virulente, complique la maitrise de cette maladie. Dans ce contexte, nous avons développé le TB-EFI et le TB IS-NTF/RINT, deux méthodes moléculaires rapides, multi
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Nguyen, Quang Huy. "Genetic determinants and evolution of drug resistance in Mycobacterium tuberculosis in Vietnam : toward new diagnostic tools." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT081/document.

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La tuberculose (TB), provoquée par Mycobacterium tuberculosis, est une des trois maladies prioritaires dans le monde. Les TB multi-résistantes (MDR) et ultra-résistantes (XDR-TB) représentent des obstacles majeurs pour la lutte antituberculeuse. Dans les pays à MDR-TB élevée, comme le Vietnam, la détection insuffisante de la résistance aux antibiotiques est un des facteurs principaux qui favorisent la transmission des souches résistantes. De plus, dans ces pays, encore très peu de choses sont connues sur la résistance à la pyrazinamide et aux antibiotiques de seconde ligne et sur les détermina
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Kuzeljevic, Brigitta. "The Potentials and Difficulties of Two New Drugs, TMC 207 and PA-824, against Drug-Susceptible and Drug-Resistant Strains of Mycobacterium tuberculosis." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-25284.

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Tuberculosis has for decades been the leading cause of death, worldwide, originating from merely one infectious matter i.e. the bacilli Mycobacterium tuberculosis (MTB). It is killing approximately 1.5 million people every year. The World Health Organization (WHO) estimates that 2 billion people might be infected by this specific bacterium, and that there emerges about 9 million new, active cases of TB each year. The aim with this thesis is to elucidate the possibilities and the difficulties with two new drugs against susceptible and resistant, latent and replicating strains of M. tuberculosis
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FRANCISCO, Samuel Nuno Furtado da Conceição. "Aplicação de sistemas moleculares na detecção rápida de MDR-TB e XDR-TB." Master's thesis, Instituto de Higiene e Medicina Tropical, 2011. http://hdl.handle.net/10362/5625.

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Mycobacterium tuberculosis é o agente etiológico da tuberculose em humanos e segundo as estimativas da Organização Mundial da Saúde, um terço da população mundial está infectada com esta bactéria, calculando-se que no ano de 2008 aproximadamente 9,4 milhões de pessoas contraíram tuberculose activa. Associada a esta tendência, encontra-se o aumento alarmante da incidência de tuberculose resistente aos antibióticos, mais propriamente da tuberculose multirresistente e extensivamente resistente. Nesta Dissertação estudaram-se três sistemas de detecção molecular (INNO-LiPA Rif. TB, Innogenetics, G
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Ni, Bin. "Immunoregulation of host macrophage responses by Mycobacterium tuberculosis." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1398946253.

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Matlola, Nthane Martha. "The in vitro anti-mycobacterial activities of the novel tetramethylpiperidyl-substituted phenazines, B4121 and B4128." Thesis, University of Pretoria, 1999. http://hdl.handle.net/2263/24462.

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The intra- and extracellular activities of 2 novel tetramethylpiperidine (TMP)-substituted phenazines, B4121 and B4128 against Mycobacterium tuberculosis H37R (ATCC 27294) were determined and compared with those of clofazimine (B663). Clofazimine, together with B4121 and B4128, were also tested for their activities against drug-resistant strains of M.tuberculosis. Both B4121 and B4128 were significantly more active than clofazimine against M.tuberculosis, including multidrug-resistant clinical strains of this microbial pathogen, demonstrating a lack of cross resistance between the riminophenaz
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Franco, Marília Masello Junqueira. "Genotipagem e pesquisa de resistência fenotípica e genética à rifampicina e isoniazida em linhagens de Mycobacterium bovis isoladas de linfonodos de bovinos de abatedouro na região centro-oeste do estado de São Paulo." Botucatu, 2016. http://hdl.handle.net/11449/143102.

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Orientador: Antonio Carlos Paes<br>Resumo: A tuberculose causada por Mycobacterium bovis (bTB) é uma zoonose de distribuição mundial com ampla gama de hospedeiros. Nos países onde a bTB é prevalente, 10 a 20% dos casos de tuberculose humana são causados por M. bovis. São escassos em todo o mundo estudos que investigam a resistência à isoniazida (INH) e rifampicina (RMP) em linhagens de M. bovis de origem bovina, reservatórios silvestres, e em casos humanos de tuberculose. Foi investigada a diversidade genotípica de 67 linhagens de M. bovis isoladas de bovinos de abatedouro, obtidas de 100 linf
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McNerney, Ruth. "Detection of mycobacterium tuberculosis." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416621.

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Cochrane, Shaun Kevern Twyman. "Antitermination in Mycobacterium tuberculosis." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446584/.

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Mycobacterium tuberculosis is the leading cause of death from a single infectious agent. The varying efficacy of the BCG vaccine and the emergence of multi-drug resistant strains of M. tuberculosis have made it essential that novel drug and vaccine targets are identified. The antitermination mechanism, probably used in transcriptional regulation of the single rrn operon, is one such target. Antitermination is a mechanism by which RNA polymerase is able to transcribe through both Rho-dependent and-independent terminators. Antitermination in association with Nus (N-utilising) factors was initial
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Alteri, Christopher. "Novel Pili of Mycobacterium tuberculosis." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1276%5F1%5Fm.pdf&type=application/pdf.

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Abate, Getahun. "Drug resistance in mycobacterium tuberculosis /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3833-4/.

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Ho, Timothy Boon Leong. "Pathogen polymorphisms of mycobacterium tuberculosis." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399538.

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Gurcha, Sudagar Singh. "Mannan biosynthesis in mycobacterium tuberculosis." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324798.

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Agranoff, Daniel David. "Cation transporters of mycobacterium tuberculosis." Thesis, St George's, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249372.

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Tho, Dau Quang. "Isoniazid resistance in Mycobacterium tuberculosis." Thesis, Open University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580139.

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Drug resistant tuberculosis (TB) is increasing worldwide and it is now estimated by the World Health Organisation (WHO) that 7% of TB cases globally are resistant to isoniazid (INH). INH is a key drug for the treatment of TB, alongside rifampicin (RIF). Understanding factors which influence the emergence and propagation of INH resistance and the influence of INH resistance on TB treatment success are vital in improving global TB control efforts. Vietnam is ranked 12th of 22 high burden countries for TB and has a high prevalence of INH resistance (25%) with a relatively modest prevalence of TB
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Machado, Kim Vinícius Amaral. "Infecção latente por mycobacterium tuberculosis." Universidade Federal do Amazonas, 2013. http://tede.ufam.edu.br/handle/tede/3420.

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Made available in DSpace on 2015-04-22T22:06:30Z (GMT). No. of bitstreams: 1 Kim Vinicius.pdf: 1711922 bytes, checksum: 8cc4a90994011dd026aa6483a81d0384 (MD5) Previous issue date: 2013-11-28<br>CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Exposure to Mycobacterium tuberculosis can trigger three distinct events in the human body, which are: elimination of bacilli; latent infection, where there is infection control, but not its elimination; or development of tuberculosis, when the immune response is insufficient to contain the infection. Undergraduate nursing stu
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Mitchell, Joni. "Reinfection dynamics of mycobacterium tuberculosis." Thesis, Cape Peninsula University of Technology, 2007. http://hdl.handle.net/20.500.11838/1474.

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Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2007<br>Reinfection is an important mechanism leading to recurrent tuberculosis. Recently, molecular epidemiological studies have shown that in high incidence settings, recurrent tuberculosis may occur through reinfection. Animal model experiments have shown that a reinfecting mycobacterial strain is specifically targeted to existing granulomas and that these structures are more dynamic than was previously thought. In this study we hypothesised that primary infection with M. tuberculosis may reprogramme human macr
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Alghhamdi, Saad Saeed. "Genotypic analysis of 'mycobacterium tuberculosis'." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536847.

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Sales, Mariana Lázaro. "Identificação de Mycobacterium bovis e Mycobacterium tuberculosis por PCR." Universidade Federal de Minas Gerais, 2012. http://hdl.handle.net/1843/SMOC-9L2PT7.

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Mycobacterium bovis and Mycobacterium tuberculosis are the causative agents of bovine and human tuberculosis, respectively. The standard diagnosis is based on the isolation and identification of bacterial colonies through biochemical methods. These methodologies in addition to being costly, require an environment with high level of biosecurity and a great time of cultivation and tests to obtain the results. The molecular tests based on the principles of real-time PCR using the fluorophore Eva Green were efficient in the identification of M. bovis and M. tuberculosis. In addition, analyses were
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Adebanjo, Omotayo David. "Knowledge, attittudes and practices of healthcare workers about prevention and control of multidrug-resistant tuberculosis at Botsabelo Hospital Maseru, Lesotho." Thesis, University of Limpopo ( Medunsa Campus), 2011. http://hdl.handle.net/10386/423.

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Thesis (MPH)--University of Limpopo, 2011.<br>Background: Tuberculosis is one of the major public health problems in Lesotho. With the occurrence of multi-drug resistant tuberculosis, little is known about the views of health care workers on this disease. The aim of this study was to investigate the knowledge, attitudes, and practices of healthcare professionals about prevention and control of MDR-TB at Botsabelo hospital, situated in Maseru, Lesotho. Methods: This study was conducted by means of a semi-structured, anonymous, and self-administered questionnaire that was sent to health care wo
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Portugal, Benavides Walter José Del Carmen. "Factores asociados a tuberculosis multidrogoresistente (TB-MDR) en pacientes con tuberculosis de la región Callao." Master's thesis, Universidad Nacional Mayor de San Marcos, 2021. https://hdl.handle.net/20.500.12672/16641.

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Determina los factores asociados a TBMDR en pacientes con TB en la región Callao en el año 2018. Realiza un estudio de tipo transversal. Se usó la base de datos y el repositorio de muestras de esputo de la Dirección Regional de Salud del Callao. Se utilizó un modelo de regresión logística para estimar los odds ratio y los intervalos de confianza al 95%. Las muestras de esputo de TBMDR fueron analizadas para determinar el linaje. Encuentra que los casos de TB sensible fueron 893 (81,6%) y 202 fueron casos TBMDR (18,4%). Los pacientes nuevos tuvieron menor riesgo de presentar TBMDR (OR = 0
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Dumartin, Catherine. "Activité de l'antiseptique chloré amukine Rsur "Mycobacterium fortuitum", "Mycobacterium tuberculosis" et "Mycobacterium avium"." Paris 5, 1994. http://www.theses.fr/1994PA05P185.

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Rachman, Helmy. "Functional genome analysis of Mycobacterium tuberculosis." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=970869746.

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Braibant, Martine. "Transport du phosphate chez Mycobacterium tuberculosis." Doctoral thesis, Universite Libre de Bruxelles, 1998. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211979.

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Krüüner, Annika. "Drug-resistant Mycobacterium tuberculosis in Estonia /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-455-0/.

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Upton, Anna M. "Arylamine N-acetyltransferase of Mycobacterium tuberculosis." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393366.

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Senaratne, Ryan Himansu. "Porin-like proteins from Mycobacterium tuberculosis." Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299006.

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Ananthakrishnan, Shilpa. "P-type ATPases in Mycobacterium tuberculosis." Digital WPI, 2009. https://digitalcommons.wpi.edu/etd-theses/1200.

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"Tuberculosis is a deadly disease caused by bacteria of the genus Mycobacterium. One-third of the world’s population is infected with Mycobacterium tuberculosis. Two million these deaths occur each year in immunocompromised AIDS patients. M. tuberculosis has co-evolved with humans for many thousands of years. The bacillus has developed tactics to overcome the immune defense system and multiply in the macrophage. At the interface of the host and pathogen interactions, there is an interchange of metals and electrolytes. The host on one hand reduces the availability of metals essential for path
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Sampson, Samantha Leigh. "Mycobacterium tuberculosis : genetic and phenotypic comparison." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/52948.

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Thesis (PhD)--University of Stellenbosch, 2002.<br>ENGLISH ABSTRACT: This study exploits the Mycobacterium tuberculosis H37Rv genome sequence data in the context of M. tuberculosis clinical isolates, to elucidate genetic variation, and examine the phenotypic and molecular epidemiological implications thereof. The study was initiated by investigation of the insertion sequence IS6110, the primary DNA fingerprinting probe for the molecular epidemiology of tuberculosis. The transposable element is present in variable copy number and chromosomal location in clinical isolates of M. tuberculos
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Moses, Lorraine. "Phenotypic factors influencing Mycobacterium tuberculosis phenotype." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/52997.

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Holloway, Laurin Nicole. "Host Defense Mechanisms Against Mycobacterium Tuberculosis." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1245878489.

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Garcia-Moreno, Pamela K. "Mycobacterium tuberculosis inhibitors: action and resistance." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3893.

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Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis, has been a global health problem for years. The emergence of drug resistance in this organism generates the necessity of exploring novel targets and developing new drugs. Topoisomerases are enzymes found in all kingdoms of life responsible for overcoming the topological barriers encountered during essential cellular processes. The genomes of mycobacteria encode only one type IA topoisomerase (MtopI), which has been validated as a novel TB drug target. The goal of this study is to obtain new information on the mechanism a
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Pandia, Fajardo Elma Alcira. "Relaciones filogenéticas entre algunos Telmatobinidos (Anura, Leptodactylidae, Telmatobiinae) de Perú basado en la morfología de los estados larval y adulto." Bachelor's thesis, Universidad Nacional Mayor de San Marcos. Programa Cybertesis PERÚ, 2006. http://www.cybertesis.edu.pe/sisbib/2006/pandia_fe/html/index-frames.html.

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La finalidad del presente estudio fue evaluar el medio de cultivo Löwenstein - Jensen modificado con nitrato de potasio (KNO3) para el diagnóstico de Mycobacterium tuberculosis, compararando la sensibilidad y especificidad de este medio modificado con el medio Löwenstein - Jensen convencional y evaluando los factores importantes que influyen en el proceso como por ejemplo el tiempo. En el presente estudio, se evaluó un total de 120 muestras provenientes de pacientes diagnosticados con tuberculosis pulmonar por baciloscopía, las muestras (esputo, lavado bronquial, aspirado bronquial, aspirado g
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Djomkam, Leopold Tientcheu. "Differences between host immune responses to `Mycobacterium tuberculosis' and 'Mycobacterium africanum'." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590516.

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Chung, Delgado Kocfa, Bravo Sonia Guillen, Montag Alejandro Revilla, and Antonio Bernabe-Ortiz. "Mortality Among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors." PLoS ONE, 2015. http://hdl.handle.net/10757/344468.

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kocfachung@gmail.com<br>soniaguillenb@gmail.com<br>armrons@gmail.com<br>Artículo de revista que fue aceptada para publicación en la Revista PLOS ONE el 03 de Febrero de 2015.<br>Background: An increase in multidrug-resistant tuberculosis (MDR-TB) cases is evident worldwide. Its management implies a complex treatment, high costs, more toxic anti-tuberculosis drug use, longer treatment time and increased treatment failure and mortality. The aims of this study were to compare mortality between MDR and drug-susceptible cases of tuberculosis, and to determine risk factors associated with mortality
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Seloma, Ngwanamohuba Mologadi. "Wild-type minimal inhibitory concentration distributions of secondline drugs in mycobacterium tubercolosis complex clinical isolated in relation to recommended critical concentrations in Limpopo Province, South Africa." Thesis, University of Limpopo, 2016. http://hdl.handle.net/10386/1712.

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Thesis (MSc. (Medical Sciences)) -- University of Limpopo, 2016.<br>The reference phenotypic methods for Mycobacterium tuberculosis drug susceptibility testing are qualitative and based on drug critical concentrations. Limitations include lack of standardization and variations in laboratory preparation of drug stock solutions. The recommended critical concentrations are determined by consensus and experience rather than scientific data. Consequently incorrect and inadequate susceptibility breakpoints are used and patients receive ineffective antimicrobial therapy. The determination of wi
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Walrath, Jessica R. "The role of alpha 4 beta 1 integrin (VIa-4) in recruitment of mycobacterium tuberculosis-specific TH1-LIKE recall responses to the human lung." Cleveland, Ohio : Case Western Reserve University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1196182534.

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Breuer, Evelyn Ndinelao. "Molecular characterisation of Mycobacterium Tuberculosis, clinical isolates obtained in the Khomas region, Windhoek, Namibia." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2692.

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Thesis (MSc (Biomedical Technology))--Cape Peninsula University of Technology, 2017.<br>According to the Namibia National Tuberculosis Control Programme (NTCP) report of 2008, Namibia has one of the highest TB infection rates in the world with a case notification rate of 748/100,000. Rapid, specific and sensitive diagnosis of Mycobacterium tuberculosis (MTB) is needed for correct TB patient management. One of the aims of this study was thus to compare direct microscopy with two rapid molecular diagnostic tools (viz. GeneXpert MTB/RIF and Hain Genotype® MTBDR plus assay) for the identification
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Bidaki, Majid Zare. "The role of IS6110 insertion element in the evolution of Mycobacterium tuberculosis." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted access until June, 15, 2010. Online version available for University member only until June 15, 2014, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25937.

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Perskvist, Nasrin. "Interaction between Mycobacterium tuberculosis and human neutrophils /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med679s.pdf.

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Mostowy, Serge. "Comparative genomics of the Mycobacterium tuberculosis complex." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111834.

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The study of microbial evolution has been recently accelerated by the advent of comparative genomics, an approach enabling investigation of organisms at the whole-genome level. Tools of comparative genomics, including the DNA microarray, have been applied in bacterial genomes towards studying heterogeneity in DNA content, and to monitor global gene expression. When focused upon the study of microbial pathogens, genome analysis has provided unprecedented insight into their evolution, virulence, and host adaptation. Contributing towards this, I herein explore the evolutionary change affecting ge
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Billington, Owen James. "Evolution of drug resistance in Mycobacterium tuberculosis." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444546/.

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This thesis examines the contrasting roles of genetic drift and selection on the emergence of drug resistance in Mycobacterium tuberculosis . In clinical practice some alleles of rifampicin resistance are isolated more frequently than others. To identify if this variation is due to genetic drift or selection, the mutation rate to rifampicin resistance in M. tuberculosis (H37Rv) was determined. PCR-SSCP analysis revealed only three patterns from the rifampicin resistant isolates, each pattern arising at the same mutation rate (Mann-Whitney U test P>0.5). Fitness, defined as the ratio of generat
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Stalford, Susanne Abigail. "Methylthioxylofuranose and oxidative protection in mycobacterium tuberculosis." Thesis, University of Leeds, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493788.

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