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Rozprawy doktorskie na temat „Medicine safety”

Autor: Grafiati
Data publikacji: 21 grudnia 2024
Data aktualizacji: 31 lipca 2025

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1

Mabunda, Hitekani Tolerance. "Innovator Medicines Versus Generic Medicine Package Inserts Safety Amendments, the Reality in South Africa." University of the Western Cape, 2017. http://hdl.handle.net/11394/6317.

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Magister Scientiae - MSc (Pharmacy Administration and Policy Regulation)<br>Availability of clinically relevant and unbiased medicine information goes a long way in promoting rational use of medicines. The package insert (PI) is one of the sources of information utilised by healthcare professionals for accessing relevant medicine information such as indications, contra-indications and special precautions (Singh, Mohan, Kumar, & Gupta,2016). It is important that the PI contains updated safety information. The safety information in the PIs of the innovator and generic medicines are expected to b
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Thornborrow-Geswind, Kirsten. "Evaluation of medicine safety reporting systems in South Africa." Thesis, Nelson Mandela Metropolitan University, 2017. http://hdl.handle.net/10948/21439.

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Pharmacovigilance is “the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problem”. To date, no comprehensive study has been performed to evaluate the pharmacovigilance system in the public health sector in South Africa. The primary aim of this study was to evaluate the current status of pharmacovigilance systems within the public healthcare sector in South Africa, and the level of functioning of these systems, in order to provide relevant recommendations, where necessary, for improvement, using the Indicat
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3

Mann, Abbey. "A Medical Perspective on Firearm Safety." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/6441.

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Denagamage, Thomas Nishantha. "Application of evidence-based medicine to veterinary science and food safety." [Ames, Iowa : Iowa State University], 2008.

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5

Moss, Brandon Price. "6-Month Effectiveness Safety and Tolerability of Ocrelizumab and Comparative Safety with Rituximab." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1579784364389245.

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6

Mullen, Carrie. "Quality Assurance of forensic investigations in toxicology and traffic safety." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5465/.

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The work described in this thesis deals with three aspects of quality assurance in the field of forensic toxicology: proficiency testing schemes, validation of analytical methods for the piperazine group of abused drugs and validation of the police field impairment test, used at the roadside to test drivers for drug-induced impairment. Proficiency Testing: Long term reviews were performed for two forensic external quality assurance schemes. Rounds 30 (in 2007) to 48 (in 2012) of the UKAS-accredited commercial Quartz Forensic Blood Toxicology Proficiency Testing Scheme (PTS), and a ten year per
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Al, Dhabbari Fatma. "Nurses' perceptions of patient safety culture in Oman." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30724/.

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Al, Salem Gheed F. "An assessment of safety climate in Kuwaiti public hospitals." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30685/.

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Background: Patient safety in healthcare organisations received global attention following the Institute of Medicine’s release of its hallmark report “To Err Is Human: Building a Safer Health System”, where it was estimated that 44,000–98,000 patients die annually in US hospitals as a result of errors in care. Similar rates of error and avoidable harm have been reported in different research studies in many modern health systems across the world. “Safety Culture” has been identified as a key element of healthcare organisations’ ability to learn from errors and reduce preventable harm to patien
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9

Carson-Stevens, Andrew. "Generating learning from patient safety incident reports from general practice." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/104070/.

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Internationally, there is an emerging interest in the inadvertent harm caused to patients by the provision of healthcare services. Since the publication of the Institute of Medicine’s report, To Err is Human, in 1999, research and policy directives have predominantly focused on patient safety in hospital settings. More recently, the World Health Organization has highlighted 2-3% of primary care encounters result in a patient safety incident. Given around 330 million general practice consultations occur in the UK each year, unsafe primary care is a poorly understood, major threat to public heal
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10

Elmi, Ahmed. "Safety of medicines with respect to drug counterfeiting in developing countries." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/52338/.

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Background: This thesis presents a study of the safety of medicines with respect to drug counterfeiting in developing countries (East Africa and the Middle East). Counterfeit medicines are also present in industrialised countries, but not on the same scale as in developing countries. The aim of the study was to establish the responsiveness of health care professionals at the practice level concerning the counterfeiting of medicinal products in developing countries focusing on six countries in the East African region and seven countries located in the Middle East. Method: The method of data acq
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11

Rooms, A. E. "Health and safety at work : Self regulation in the multi retail industry." Thesis, University of Salford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381663.

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12

Strandell, Johanna. "Drug interaction surveillance using individual case safety reports." Doctoral thesis, Linköpings universitet, Klinisk farmakologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-70424.

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Background: Drug interactions resulting in adverse drug reactions (ADRs) represent a major health problem both for individuals and society in general. Post-marketing pharmacovigilance reporting databases with compiled individual case safety reports (ICSRs) have been shown to be particularly useful in the detection of novel drug - ADR combinations, though these reports have not been fully used to detect adverse drug interactions. Aim: To explore the potential to identify drug interactions using ICSRs and to develop a method to facilitate the detection of adverse drug interaction signals in the
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13

Hilario, Grace. "Patient Safety Problems, Procedures, and Systems Associated with Safety Reporting and Turnover." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7103.

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Research has shown that 400,000 people die every year due to preventable medical errors. Medical error reporting and safety is a responsibility of all members of a health care organization. Creating an environment that addresses and prevents potential or actual safety problems can help reduce the incidence of medical errors made by nurses in the workplace. The purpose of this quantitative research study was to determine if nurses' perceptions of safety problems and error-preventing procedures and systems affected their comfort in reporting safety problems and intent to leave. High-reliability
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14

Doherty, Colin. "Safety and performance in combat sports." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2025. https://ro.ecu.edu.au/theses/2937.

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Background: Athletes in mixed martial arts (MMA) and Muay Thai (MT) face challenges before, during, and after competition, including hydration testing, disordered eating (DE), rapid weight changes (RWC), and health problems (HP). These issues can affect athletes' health and performance and raise regulatory and safety concerns for governing bodies like the Western Australia Combat Sports Commission (WACSC). However, these challenges are poorly described in the context of MMA and MT, as most of the existing research focuses on Olympic combat sports. This thesis addresses these challenges in MMA
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15

Carr, T. L. "A study of innovation and the management of safety in the mining industry." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292252.

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16

Cohen, Kirsten Lesley. "Patient waiting times within public Emergency Centres in the Western Cape: describing key performance indicators with respect to waiting times within Western Cape Emergency Centres in 2013-2014." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/27366.

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Background: Much emphasis has been placed on Quality Measurements or Key Performance Indicators in Emergency Medicine. Internationally, KPI's are used to measure and improve quality of care, with a major emphasis on waiting times, measured as time-based KPI's. These times are related to the various stages of a patient journey through the Emergency Center. In South Africa this has not been routinely done. The Western Cape has conducted audits in recent years to measure these. This study aims to provide a snapshot of waiting times (specifically time to triage, time to doctor, time to disposition
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17

Murray, Brett Richard. "The use of emergency lights and sirens by ambulances and their effect on patient outcome and public safety." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21225.

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Thesis (M.A.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>The use of emergency lights and sirens as warning devices by ambulances is a hotly debated topic within the Emergency Medical Services. For the last few decades, research has shown that lights and sirens have only a minimal effect
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18

Walker, Janeane. "Nurses' Perception of Their Role in Patient Safety." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5434.

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Despite efforts to ensure patient safety in the United States, patients are being harmed by preventable errors. There is a gap in the literature from the nurse's perspective as to why medical errors continue to occur despite having evidence-based safety strategies available. The purpose of this constructivist grounded theory study was to develop a theory explaining nurses' perception of their role in patient safety and why medical errors are still occurring despite implementation of evidence-based safety strategies. The systems engineering initiative for patient safety (SEIPS) model provided t
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19

Scarfe, L. N. "Investigating the safety and efficacy of regenerative medicine therapies in mouse models of kidney disease." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3008791/.

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Acute kidney injury (AKI) and chronic kidney disease (CKD) are serious health problems with high morbidity and mortality. There are currently no specific treatments available to patients with AKI or CKD, and many patients require renal replacement therapy to survive. Cell-based regenerative medicine therapies have shown potential for treating AKI and CKD in preclinical models, however conventional methods of measuring kidney function and tracking exogenously administered cells are not ideal. Novel imaging-based methods provide an alternative approach, allowing kidney function and cell biodistr
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20

Jones, Sarahjane. "A stakeholder derived framework for safety assessment in the NHS case management programme." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/64012/.

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Patient safety measurement methods are dominated by outcome measurement, reducing them to counts of harm or adverse events. Performance measurement recognises the limitations of the sole use of outcome indicators and proposes the use of measures throughout the system, in particular the determinants of the desired outcomes. Furthermore, it promotes stakeholder engagement in the design of measures in order to understand their expectations and how they contribute. This is particularly important in healthcare services, such as the NHS case management programme, where patient contribution is growin
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21

Berg, Hans-Yngve. "Understanding Subgroups of Novice Drivers : A Basis for Increased Safety and Health." Doctoral thesis, Linköping : Univ, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5037.

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22

Mozid, Abdul M. "Safety and efficacy of bone marrow derived progenitor cells in patients with chronic ischaemic heart failure." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8396.

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Bone marrow stem/progenitor cell (BMSC) therapy for cardiac repair in humans is yet to fulfil the exciting potential demonstrated in preclinical experiments. This thesis presents three clinical studies addressing some of the unresolved issues regarding the ideal delivery method, the effect of patient-related factors on progenitor cell concentration/function and the possible biological mechanism(s) of action. The first study describes the intramyocardial arm of the REGENERATE-IHD trial- a randomised controlled trial assessing the efficacy of mobilised BMSCs in patients with ischaemic heart fail
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23

Tang, Jessica Janice. "The implementation of occupational safety and health legislation and policies in Hong Kong schools." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/11904/.

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It is widely acknowledged that Hong Kong teachers are suffering from work-related health and safety problems (HKPTU, 2005). Reviews of Occupational Safety and Health (OSH) research suggest that there is a wealth of scientific data on OSH to establish policy level interventions, yet the implementation of OSH legislation and policies is complex and multi-faceted. This thesis focuses on the macro level of OSH interventions in schools by studying the OSH policy implementation from the top-down and organisational perspectives. This thesis begins with a systematic narrative review of the OSH policy
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Zarychanski, Ryan. "Evaluating the efficacy and safety of unfractionated heparin in patients diagnosed with sepsis." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28822.

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Statement of the Problem: Unfractionated heparin (UFH) is an anticoagulant with anti-inflammatory properties. The efficacy and safety of UFH in severe sepsis or septic shock has yet to be evaluated in clinical trials. Methods of Investigation: We performed a systematic review to evaluate the current evidence regarding the use of heparin in patients with sepsis. We then conducted a cross-sectional survey to evaluate the perceived utility and current use of anticoagulants in sepsis, to assess the degree of certainty regarding clinical benefits and harms of heparin, and to assess the willingness
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25

Palminha, Joana Isabel Mariano. "Segurança de fármacos citotóxicos em medicina veterinária versus medicina humana." Bachelor's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2010. http://hdl.handle.net/10400.5/2811.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A utilização de fármacos citotóxicos em Medicina Humana iniciou-se na década de 40, e desde então tem vindo a evoluir, tornando-se numa prática corrente na terapêutica oncológica. A exposição a estes fármacos representa um risco de saúde ocupacional, documentado em diversos estudos. Por esta razão, em Medicina Humana, as regras de segurança para a manipulação destes fármacos constituem um assunto muito discutido, existindo um grande número de entidades e organizações que elaboram documentos, contendo as normas orientadoras para
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26

Ådahl, Kerstin. "On Decision Support in Participatory Medicine Supporting Health Care Empowerment." Doctoral thesis, Blekinge Tekniska Högskola, Sektionen för datavetenskap och kommunikation, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-00515.

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The task of ensuring Patient Safety is, more than ever, central in Healthcare. The report “To Err is Human” [Kohn et al. 2000], was revealing alarming numbers of incidents, injuries and deaths caused by deficiencies in healthcare activities. The book initiated assessment and change of Healthcare methods and procedures. In addition, numerous reports to Swedish HSAN (Medical Responsibility Board) have shown a high rate of information and communication deficiencies in Healthcare has a direct or indirect cause of incidents, injuries and deaths. Despite numerous of new sophisticated tools for infor
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Olayanju, Olatunde. "Efficacy and safety of novel and repurposed drugs for the treatment of drug-resistant tuberculosis." Doctoral thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/32322.

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Background: There is widespread concern about the rise of drug-resistant TB because treatment outcomes of affected patients remain poor and treatment options are limited. After more than a forty-year gap without any breakthrough discovery, several new (bedaquiline and delamanid) and repurposed drugs (linezolid) are increasingly becoming available for use. However, data regarding the efficacy and safety of these drugs in drug-resistant TB patients, with or without HIV infection, from a real-life programmatic setting are lacking. This thesis aims to address that knowledge gap and provide informa
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Cooter, Rodney D. "Craniofacial fracture patterns : a thesis submitted for the degree of Doctor of Medicine /." Title page, contents and abstract only, 1990. http://web4.library.adelaide.edu.au/theses/09MD/09mdc779.pdf.

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Jeyaretnam, Joseph S. "Occupational hazards and radiation safety in veterinary practice including zoo veterinary practice in Australia." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2003. https://ro.ecu.edu.au/theses/1306.

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This thesis contains reviews and research on the occupational hazards of zoo veterinary practitioners in Australia. Although occupational hazards have long been recognised in the veterinary profession, little information is available on the number and magnitude of injuries to veterinarians in Australia, the United Kingdom or the United States. Apart from anecdotal accounts and some limited data, most of the available information is on occupational zoonoses, generally well recognized by veterinarians. Other occupational hazards to which veterinarians are exposed have received scant attention. T
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Reilly, Mark Stephen John. "Epidemiological and geographical aspects of the occupational safety and emergency survival of United Kingdom fishermen, 1961-85." Thesis, University of Dundee, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302260.

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31

Tombs, Stephen Peter. "The nature and limitations of the legal regulation of health and safety in the UK chemical industry." Thesis, University of Wolverhampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303691.

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This thesis examines the nature of the current legal regulation of occupational safety and health in Britain, and aims to understand the limitations of such regulation. This aim also leads us to consider the potential for, and the means of securing, improvements in safety and health performance in the UK chemical industry. Having set the research in context and addressed some pertinent methodological issues, the thesis begins by providing an overview of existing safety and health legislation, both in relation to manufacturing industry in general, and then in relation to the chemical industry m
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Parihar, Vishal Singh. "Human listeriosis : sources and routes." Doctoral thesis, Örebro : Örebro University Library, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-2447.

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33

Fasting, Sigurd. "Routine based recording of adverse eventsduring anaesthesia : application in quality improvement and safety." Doctoral thesis, Norwegian University of Science and Technology, Faculty of Medicine, 2003. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-327.

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34

Rydningen, Lene Christin. "Medicine Management and Administration : How might we improve patient safety through medicine management and administration in inpatient care units in somatic hospitals in Sweden and Norway?" Thesis, Umeå universitet, Designhögskolan vid Umeå universitet, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152356.

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<p><strong>Introduction</strong></p><p>This thesis explores how we can increase patient safety through medicine management and administration in inpatient care units in somatic hospitals in Sweden and Norway by combining tools and systems which allows nurses to work safely, precicely, and efficiently whenever they are managing or administering medication to patients. </p><p></p><p><strong>Background</strong></p><p>Nurses have the formal, academic, and moral responsibility in medicine management and administration in hospitals (1). The nurse must ensure that the medication is given to the corre
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35

Pal, Arindom. "Development of a new class of ligand-targeted chemotherapeutics with enhanced safety and efficacy profile." Scholarly Commons, 2019. https://scholarlycommons.pacific.edu/uop_etds/3642.

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The hydrophobicity of many chemotherapeutic agents usually results in their nonselective passive distribution into healthy cells and organs causing collateral toxicity. Ligand-targeted drugs (LTDs) are a promising class of targeted anticancer agents. The hydrophilicity of the targeting ligands in LTDs limits its nonselective passive tissue distribution and toxicity to healthy cells. In addition, the small size of LTDs allows for better tumor penetration, especially in the case of solid tumors. However, the short circulation half-life of LTDs, due to their hydrophilicity and small size, rem
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Chan, Derwin King Chung. "Integrating social psychological theories of motivation and intention to explain health and safety behaviours." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12826/.

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The work within the thesis aimed to integrate concepts from three psychological frameworks, including self-determination theory (SDT), the theory of planned behaviour (TPB), and the hierarchical model of motivation (HMM), into a model to understand the processes that underpin motivation and intention toward health and safety behaviours. The first tenet of the model (derived from SDT and HMM), namely the trans-contextual effect of motivation, hypothesised that self-determined motivation for a given activity related to self-determined motivation for undertaking health-promoting behaviour associa
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Bleetman, Anthony. "Safety standards for police body armour." Thesis, University of Birmingham, 2000. http://etheses.bham.ac.uk//id/eprint/692/.

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Assaults on the Police continue to increase. Of particular concern is the threat of injury from edged weapons. Shootings remain rare. The Home Office has embarked on a program to provide all police officers with suitable body armour. Body armour has been on general issue to police officers in America for over twenty years and has a superb record in saving lives from shootings. Little is known about its ability to prevent serious stab wounds from knives, as this is a much less common threat in the American policing environment. Therefore the specification for armour for police use in this count
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Al-Ismail, Deana. "Clinical studies to broaden the application and improve the safety of psoralen and ultraviolet A (PUVA) phototherapies." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/100479/.

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This medical doctorate thesis contains clinical studies to broaden the application and to improve the safety and efficacy of ultraviolet (UV) A phototherapies, the main focus being to enhance the current clinical practice of topical psoralen photochemotherapy (PUVA). The thesis includes three studies: 1. The validation of a semi-automated Minimal Phototoxic Dose (MPD) Tester for topical photochemotherapy Thirty seven psoriasis patients referred to the phototherapy unit at St. Woolos, Newport were recruited. Patients had two sets of minimal phototoxic dose (MPD) tests performed on symmetrical,
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Wenzel-Smith, Gisela. "Safety and efficiency of procedural sedation and analgesia (PSA) conducted by medical officers in a level one hospital in Cape Town." Master's thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/10872.

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Objectives: This study aimed to research efficacy and safety of procedural sedation and analgesia (PSA) administered by medical officers (MOs), without formal anaesthetic training, in a South African district hospital. Design: This is a retrospective descriptive study. Setting: The study took place in the Emergency Department (ED) of False Bay Hospital (FBH), a level one hospital in the Southern suburbs of the Cape Town Metro health district.
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Cooper, Mark Dominic. "An examination of assigned and participative goal-setting in relation to the improvement of safety in the construction industry." Thesis, University of Manchester, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284229.

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Bofill, Pumarola Andreu 1993. "The Impact of the human endogenous metabolome on drug pharmacology and safety." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/671531.

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A great deal of efforts has been made to improve and expand pharmacological testing and optimisation of drug candidates during the discovery process. However, we are yet to understand fully why drugs require certain levels of affinity for their mechanism of action targets to exert their therapeutic effect. In parallel, the mechanistic understanding of the endogenous metabolome has been demonstrated to have incredible implications in drug discovery, being potentially one of the pillars of precision medicine. Endogenous metabolites are small molecules evolutionally optimised to interact in
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42

BARBOZA, ALEX. "Gestao de rejeitos radioativos em servicos de medicina nuclear." reponame:Repositório Institucional do IPEN, 2009. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9377.

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Made available in DSpace on 2014-10-09T12:26:21Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:09:59Z (GMT). No. of bitstreams: 0<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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43

Barnett, Michael Leonard. "Human error and maritime safety : an exploration of the causes of marine casualties and the design of simulator-based training programmes to develop the skills of safe vessel control." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325708.

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44

Wu, Hon-Fan. "A study of behavioural change in occupational safety in a metal works at Shenzhen, China." Thesis, University of Hull, 2001. http://hydra.hull.ac.uk/resources/hull:8284.

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The present study applied a combined behavioural and attitudinal approach in occupational safety in a Hong Kong-based metal house in Shenzhen, China in an attempt to modify the safety behaviours and attitudes of the workers by means of posted feedback plus goal-setting. To the best of the researcher's knowledge, this is the first study of this type to be attempted in a Chinese industrial setting. A total of 142 respondents from the four departments, namely Heavy Duty, Small Press, Hand Press and Drilling were involved in the survey with a multiple-based line design for an environment where ran
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Layland, Jamie. "Utility and safety of invasive (fractional flow reserve) and non-invasive (cardiac magnetic resonance imaging) diagnostic tests in patients with NSTEMI." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7713/.

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A prospective randomised controlled clinical trial of treatment decisions informed by invasive functional testing of coronary artery disease severity compared with standard angiography-guided management was implemented in 350 patients with a recent non-ST elevation myocardial infarction (NSTEMI) admitted to 6 hospitals in the National Health Service. The main aims of this study were to examine the utility of both invasive fractional flow reserve (FFR) and non-invasive cardiac magnetic resonance imaging (MRI) amongst patients with a recent diagnosis of NSTEMI. In summary, the findings of this t
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Huitfeldt, Anders. "Emulation of Target Trials to Study the Effectiveness and Safety of Medical Interventions." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:23205172.

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Ideally, clinical guidelines would be informed by well-designed randomized experiments. However, it is generally not possible to conduct a randomized trial for every clinically relevant decision. Decision makers therefore often have to rely on observational data. Guidelines that rely on observational data due to the absence of randomized trials benefit when the analysis mimics the analysis of a hypothetical target trial. This can be achieved by explicitly formulating the protocol of the target trial, and thoroughly discussing the feasibility of the conditions that must be met in order to valid
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Kruger, Jeanne-Marié. "Efficacy and safety of acidified enteral formulae in tube fed patients in an intensive care unit /." Link to online version, 2006. http://hdl.handle.net/10019/564.

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Pajor, Nathan M. M. D. "Improving the Rate of Home Ventilator Alarm Use in a Pediatric Pulmonary Medicine Clinic." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554214546651399.

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Dotterweich, Andy R. "University School Playground Inventory and Safety Evaluation." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/3808.

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Farag, Mohamed S. "Development of Resilient Safety-Critical Systems in Healthcare Using Interdependency Analysis and Resilience Design Patterns." Thesis, The George Washington University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10981524.

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<p> In the U.S. medical sector, software failures in safety-critical systems in healthcare have led to serious adverse health problems, including patient deaths and recalls of medical systems. Despite the efforts in developing techniques to build resilient systems, there is a lack of consensus regarding the definition of resilience metrics and a limited number of quantitative analysis approaches. In addition, there is insufficient guidance on evaluating resilience design patterns and the value they can bring to safety-critical systems. </p><p> This research employed the interdependency analy
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