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Rozprawy doktorskie na temat „Membrane, Basement”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 20 lutego 2023

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1

Cleutjens, Jacobus Peter Marie. "Basement membrane heterogeneity." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=5472.

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2

Wootton, Andrew. "The glomerular basement membrane and nephritis /." Title page, contents and abstract only, 1985. http://web4.library.adelaide.edu.au/theses/09PH/09phw918.pdf.

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3

Devaka, K. Weerakoon Cheung H. Tak. "Interaction of macrophages with the basement membrane." Normal, Ill. Illinois State University, 1995. http://wwwlib.umi.com/cr/ilstu/fullcit?p9603526.

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Thesis (Ph. D.)--Illinois State University, 1995.<br>Title from title page screen, viewed May 8, 2006. Dissertation Committee: Hou Tak Cheung (chair), David W. Borst, Herman E. Brockman, Alan J. Katz, Anthony J. Otsuka. Includes bibliographical references (leaves 98-110) and abstract. Also available in print.

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4

Visser, Robbert. "Basement membrane antigens in preneoplastic and neoplastic conditions." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=5867.

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5

Melian, Nadia. "Basement membrane composition of Dag1 null chimaeric mice kidneys." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33809.

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The growth of an organism involves the proliferation and migration of cells within an extracellular matrix. As a cell surface receptor, the Dag1 gene product dystroglycan links the intracellular cytoskeleton to the extracellular basement membrane in many cells. Thought to act as a structural protein dystroglycan may also participate in signal transduction. This study aims to better understand the role of dystroglycan during kidney morphogenesis. I hypothesised that a lack of dystroglycan in the precursor cells of the kidney could lead to altered kidney growth. Chimaeric mice deficient in dystr

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6

Burton, Victoria Jane. "Neutrophil migration through endothelial cells and their basement membrane." Thesis, University of Birmingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532273.

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7

Forster, Simon J. "Basement membrane proteins and the spread of rectal cancer." Thesis, University of Leicester, 1987. http://hdl.handle.net/2381/35223.

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Antisera to the basement membrane proteins laminin, fibronectin and type IV collagen were prepared, characterized and rendered monospecific by appropriate treatments. Methods were developed to allow the use of these antisera for inmunohistochemical staining of sections of tissue which had been preserved by several methods. In particular, the use of protease digestion {"unmasking") to allow staining of formalin-fixed, paraffin-embedded material was studied. The presence and intensity of staining was found to be highly dependent on the protease and the conditions of digestion, the type of baseme

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8

Garton, Rosemary Louise. "The influence of basement membrane proteins on re-vascularization networks formed after acute injury." Thesis, The University of Sydney, 1997. http://hdl.handle.net/2123/4817.

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9

Zhang, Xu. "Basal lamina genes affected in leiomyomatosis and congenital muscular dystrophy : structure and mutation analyses of the collagen COL4A6 and laminin LAMA2 genes." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2780-4.

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10

Li, Yi-Yang Cheung H. Tak. "Basement membrane and its components on lymphocyte adhesion, migration, and proliferation." Normal, Ill. Illinois State University, 1992. http://wwwlib.umi.com/cr/ilstu/fullcit?p9234466.

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Thesis (Ph. D.)--Illinois State University, 1992.<br>Title from title page screen, viewed January 27, 2006. Dissertation Committee: H. Tak Cheung (chair), Anthony Otsuka, Alan Katz, Brian Wilkinson, David Weber. Includes bibliographical references (leaves 108-120) and abstract. Also available in print.

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11

Shima, Thomas Brent. "Isolation, structural and immunohistochemical characterization of basement membrane heparan sulfate proteoglycan." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61197.

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Heparan sulfate proteoglycan (HSPG) was isolated from the mouse Engelbreth-Holm-Swarm (EHS) tumor. Polyclonal antibodies against the isolated HSPG were raised by two separate techniques, both producing highly reactive antisera. The antisera were found to be reactive against epithelial basement membrane of the mouse foot pad, glomerular basement membrane of the kidney and the EHS tumor matrix using the techniques of light microscopic immunoperoxidase on frozen sections and electron microscopic immunogold labelling on ultrathin Lowicryl K4M sections. At high magnification of the EHS tumor matrix

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12

Tein, Mark S. C. "Studies on basement membrane permeation : models of pathogenic mechanims of glomerulonephritis." Thesis, University of Oxford, 1994. http://ora.ox.ac.uk/objects/uuid:22440bfc-e712-4f7c-a11d-2eed9b07bcb6.

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The effects of the biological cross-linker transglutaminase, the neutrophil oxidant hydrogen peroxide, and neutrophil proteinases on glomerular basement membrane permeability have been examined using an in vitro model of glomerular ultrafiltration. The main focus of the study lies in determining whether any of the test agents were able to render glomerular basement membrane more permeable to protein. Guinea pig liver transglutaminase was used as a model enzyme to test for the effect of biological cross-linkers on glomerular basement membrane permeability. It cross-linked glomerular basement me

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13

Levy, Somin Gabriel. "The iridocorneal-endothelial syndrome : a study of cell and basement membrane pathology." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309311.

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14

Pereira, Inês Tavares Pinto de Sá. "Basement membrane alterarions in kernicteric brain microvasculature and pericyte response to bilirubin." Master's thesis, FCT-UNL, 2011. http://hdl.handle.net/10362/6771.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>Kernicterus is a neuropathological condition characterized by deposition of unconjugated bilirubin (UCB) in specific brain regions that can lead to permanent sequelae and death, particularly in premature infants. UCB-induced toxicity has been studied in nerve and glial cells and, more recently, in brain microvascular endothelial cells. However, the effects of UCB on pericytes or on the basement membrane were never reported. We performed in vitro studies to assess apoptotic death, nitrosative stress and inflam

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15

Wheatcroft, Alison Clare. "Detection of type IV collagen degradation in inflammatory bowel disease." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310765.

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16

Walton, H. A. "The effect of structural modifications on the permeation properties of renal basement membrane." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382711.

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17

McGrath, John Alexander. "Abnormalities of wound healing and basement membrane zone composition in dystrophic epidermolysis bullosa." Thesis, King's College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343791.

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18

Fields, Christopher J. "Functional and Expression Analysis of a Novel Basement Membrane Degrader in Drosophila Melanogaster." TopSCHOLAR®, 2016. http://digitalcommons.wku.edu/theses/1633.

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The Srivastava Lab is focused on the identification and characterization of genes that play a role in basement membrane remodeling. Previously, we identified putative basement membrane degraders through a genetic screen. One such gene has been suggested to play a role in the maintenance of the stem cell niche in Drosophila melanogaster, but no other information about the role this gene plays in development or disease has been published. Here, data are presented from experiments utilizing Drosophila genetics and immunohistochemistry that provide important insights on the biological role of this

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19

Falcone, Sara. "Nephrotic syndrome and glomerular basement membrane : genetic defect of the laminin α5 chain". Thesis, Open University, 2018. http://oro.open.ac.uk/56060/.

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Nephrotic syndrome is a heterogeneous group of disorders characterised by renal and extra-renal manifestations. Classic symptoms of nephrotic syndrome include severe proteinuria, hypoalbumiaemia, oedema and hyperlipidaemia. Genetic studies of hereditary forms of nephrotic syndrome have led to the identification of proteins playing a crucial role in slit diaphragm signalling, regulation of actin cytoskeleton dynamics and cell-matrix interactions. The laminin α5 chain is a 404 kDa protein essential for embryonic development and, in association with laminin β2 and laminin γ1, it is a major compon

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20

Aypek, Hande [Verfasser]. "Loss of P3h2 gene causes thin basement membrane nephropathy in mice / Hande Aypek." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/124083554X/34.

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21

Martin, P. (Paula). "Type IV collagen:characterization of the COL4A5 gene, mutations in Alport syndrome, and autoantibodies in Alport and Goodpasture syndromes." Doctoral thesis, University of Oulu, 2000. http://urn.fi/urn:isbn:9514256867.

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Abstract Type IV collagen is only found in basement membranes, where it is the major structural component, providing a framework for the binding of other basement membrane components and a substratum for cells. The type IV collagen molecule is triple-helical and composed of three a chains which exist as six distinct forms (α1 - α6). Abnormalities in this basement membrane collagen structure and function are connected to both inherited and acquired diseases. Alport syndrome is a hereditary kidney disease associated with extrarenal complications, such as sensorineural deafness and eye abnorma

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22

McKenna, Declan Joseph. "Studies of the 67 kilodalton laminin receptor in retinal vasculature." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300777.

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23

Ali, Layla. "The structure and organization of type IV collagen in normal and glycated basement membrane." Thesis, University of Exeter, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413294.

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24

Murray, Iain Colquhoun. "The immunohistochemical localization of basement membrane components to secretory organelles is observed in the youngest endothelial cells of the rat incisor, suggesting that the synthesis of basement membrane components occurs mainly in young cells." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65989.

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25

Frith, P. A. F. "A study of eye involvement in autoimmune and inherited disorders of the basement membrane zone." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599235.

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26

Tang, Hailin. "Tissue specificity of a baculovirus-expressed, basement membrane-degrading protease in larvae of Heliothis virescens." [Ames, Iowa : Iowa State University], 2008.

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27

Salo, S. (Sirpa). "Laminin-5:function of the γ2 chain in epithelial cell adhesion and migration, and expression in epithelial cells and carcinomas". Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514253426.

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Abstract Laminins are basement membrane glycoproteins consisting of three polypeptide chains α, β and γ. Until now 12 members of the protein family have been characterized and all isoforms have an αβγ chain composition, but they assemble in varying combinations of chain variants. The functional properties of laminins include cell adhesion, proliferation, differentiation, growth and migration. Laminin-5 has a chain composition of α3β3γ2 with the distribution mainly restricted to epithelial basement membranes, where its biological functions involve anchorage and locomotion of cells. The

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28

Feru, Jezabel. "Etude de la diminution du collagène IV au cours du vieillissement cutané et des mécanismes impliqués." Thesis, Reims, 2013. http://www.theses.fr/2013REIMS006/document.

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Le vieillissement cutané s'accompagne d'altérations des composants de la matrice extracellulaire. Des études ont montré que le contenu en collagène IV diminuait dans la peau à partir de 35 ans. Le collagène IV, constituant majeur des membranes basales, est formé de l'association, en triple hélice, de 3 chaînes alpha parmi 6 possibles: alpha1(IV) à alpha6(IV). Au niveau de la membrane basale cutanée, encore appelée jonction dermo-épidermique, seulement deux isoformes de collagène IV ont été mises en évidence : [alpha1(IV)2; alpha2(IV)], isoforme majoritaire, et [alpha5(IV)2; alpha6(IV)], isofor

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29

Vatansever, Hafize Seda. "Analysis of basement membrane regulation and deposition during early mouse development in vivo and in vitro." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364209.

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30

Bolton, Glen R. (Glen Reed) 1970. "Permeation of ficoll and ficoll sulfate through glomeruler basement membrane : effects of molecular size and charge." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/50390.

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31

Flinchum, Dane Alan. "Characterizing the Role of CP1 in Drosophila Melanogaster: Its Effects on Basement Membrane Degradation and Signaling." TopSCHOLAR®, 2018. https://digitalcommons.wku.edu/theses/2642.

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CP1 is a well-conserved cathepsin L-like protease essential for proper growth and development in Drosophila melanogaster. Previous research has demonstrated that CP1 has the ability to break down the extracellular matrix. Using the UAS-GAL4 system, immunohistochemistry, and antibody-staining, this research attempts to characterize the role of CP1 and its effects on basement membrane degradation and signaling. These effects include actions at the cellular level and on a known signaling pathway. The genes involved in this pathway are known to be required for proper development of the wing disc i

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32

Elamaa, H. (Harri). "Type XVIII collagen:characterization of the primary structure and expression pattern of different variants in Xenopus laevis, characterization of the human gene structure and analysis of transgenic mice expressing endostatin." Doctoral thesis, University of Oulu, 2004. http://urn.fi/urn:isbn:9514275691.

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Abstract In this work the type XVIII collagen has been studied by using several approaches, such as different animal models. The primary structure of frog, Xenopus laevis, type XVIII collagen and the expression pattern of its variants during early embryogenesis have been elucidated. The gene structure of human type XVIII collagen was characterized and the localization and processing of its longest variant was studied by generated antibodies. In addition, the function of the proteolytically released C-terminal part of type XVIII collagen, endostatin, was studied by generating transgenic mice ex

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33

Bevacqua, Sandra Jean. "An in vitro study of human melanoma tumor cell metastasis: Cytological and molecular events during extravasation." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184746.

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In order to study the process by which human melanoma cells achieve invasion of basement membranes, a modification of the Membrane Invasion Culture System was developed to allow the in vitro collection of invasive tumor cells from heterogeneous tumor cell populations. A significant increase in the number of double minute chromosomes was observed in metaphase nuclei of the low metastatic A375P human melanoma cells which had invaded 2 consecutive amniotic membranes over that of cells in the control groups. After 25 days in culture, the incidence of double minutes had dropped below the control ra

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34

Lummerstorfer, Judith-Antonia. "The significance of the laminin-nidogen-1-interaction for basement membrane formation and stability in embryoid bodies." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962023485.

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35

Öhlund, Daniel. "Basement membrane collagens in pancreatic cancer : novel stroma-derived tumor markers and regulators of cancer cell growth." Doctoral thesis, Umeå universitet, Kirurgi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37555.

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Background: Among the common malignancies, pancreatic cancer has the shortest long-term survival. The aggressive, rapid, and infiltrative growth pattern of pancreatic cancer, together with the lack of specific symptoms, often leads to late diagnosis. Metastases are frequently found at the time of diagnosis, which prevents curative surgical treatment. Good tumor markers would enable early detection, thus improving the prognosis. Unfortunately, no such markers are available in the clinic. The tumor stroma is defined as the non-malignant cells and the extracellular matrix (ECM) of a cancer. Pancr

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36

Germundsson, Johan. "Surgical outcomes of phototherapeutic keratectomy on Epithelial basement membrane dystrophy, and the characterisation of Bowman´s Layer." Doctoral thesis, Linköpings universitet, Avdelningen för neurovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-106248.

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Background. Epithelial basement membrane dystrophy (EBMD) is a common disease of the anterior cornea that can lead to problems with vision and/or painful recurrent erosions of the corneal epithelium. Several treatment options have been used, but recurrence of EBMD after treatment is a problem. Excimer laser phototherapeutic keratectomy (PTK) has become an increasingly popular surgical option in recent years due to its accuracy, reproducibility, and good clinical outcomes. When treating EBMD with PTK, the anterior corneal structures including the epithelium, Bowman´s layer (BL), and subbasal ne

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37

Klaentschi, Karel. "The use of Matrigel for in vitro studies of basement membrane permeability under static and dynamic pressures." Thesis, University of Exeter, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337744.

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38

Leow, Chon Kar. "The long-term metabolic function of pancreatic islet grafts and the effect on glomerular basement membrane thickness." Thesis, University of Bristol, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358194.

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39

Kumar, Tarun. "The role of the basement membrane and its receptors in the morphogenesis of the Drosophila Malpighian tubules." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708732.

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40

Morss, Alisa Sharon. "Endothelial cells and basement membrane : a co-regulatory unit for fibroblast growth factor-2 in hyperglycemic stress." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/36167.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2006.<br>Includes bibliographical references.<br>Endothelial cells and basement membrane interact as a biochemical and mechanical co-regulatory unit. The wide spectrum of manifestations of diabetic vascular disease could be related to altered kinetics of vasoactive compounds within this regulatory unit. We hypothesized that hyperglycemic stress mediates storage, release, and function of fibroblast growth factor-2 (FGF-2) through changes in interaction between endothelial cells and basement membrane. We discovered that bas

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41

Francis, Michael. "RECAPITULATING OSTEOBLASTOGENESIS WITH ELECTROSPUN FIBRINOGEN NANOFIBERS AND ADIPOSE STEM CELLS AND ELECTROSPINNING ADIPOSE TISSUE-DERIVED BASEMENT MEMBRANE." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2025.

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To repair, replace, or regenerate damaged or diseased tissue has been a long-standing, albeit elusive, goal in medical research. Here, we characterize patient-derivable mesenchymal stem cell types, termed adipose-derived stem cells (ASCs). These cells, which can be derived from liposuction fat and lipoaspirate saline, are sources for patient-derivable extracellular matrix (ECM), fibrinogen (Fg) and adipose tissue extracellular matrix, and may prove useful for synthesizing new bone tissue analogues in vitro. Traditionally and rapidly isolated ASCs were thoroughly characterized as multipotent,

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42

Kurz, Angela [Verfasser], and Markus [Akademischer Betreuer] Sperandio. "MST1 kinase is critical for neutrophil transmigration through the vascular basement membrane / Angela Kurz ; Betreuer: Markus Sperandio." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1117473902/34.

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43

Cox, Melissa Luanne. "Identification of a mutation in COL4A5 causative for X-linked Alport syndrome in the domestic dog and analysis of gene expression in the kidneys of affected and nonaffected siblings." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/244.

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The domestic dog, Canis lupus familiaris, plays many roles in the lives of humans. Additionally, the dog is recognized for its potential as a model for many human hereditary diseases. Thus, the genetics and genomics of the dog are being studied extensively in order to facilitate its use as a model, as well as to help the dog for its own sake. As part of this research effort, our laboratory has added type I markers (i.e., the acidic and basic keratins, c-kit, type I and IV collagens, and the gene encoding uromodulin) to the emerging map of the canine genome. The mapping of genes, particularly t

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44

Muona, A. (Anu). "Type XV collagen:complete structures of the human COL15A1 and mouse Col15a1 genes, location of type XV collagen protein in mature and developing mouse tissues, and generation of mice expressing truncated type XV collagen." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514265858.

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Abstract This study was initiated to elucidate the complete genomic structures of type XV collagen in man and mouse and the functional properties of their promoters, as well as to obtain knowledge of the biological role of type XV collagen during development and maturity using immunofluorescence and transgenic techniques. The cloning and characterization of genomic clones revealed that the human COL15A1 gene is 145-kb in size and consists of 42 exons, and the mouse Col15a1 gene is 110-kb with 40 exons. The genomic organization of the two genes was found to be highly conserved, except

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45

Kinnunen, A. (Aino). "Collagen XVIII regulates basement membrane integrity:specific effects of its isoforms on the choroid plexus, kidney and hair follicle." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514294112.

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Abstract Collagen XVIII is a multidomain basement membrane proteoglycan with three tissue-specific isoforms. Endostatin, the C-terminal part of collagen XVIII, has antiangiogenic properties, while the frizzled-like domain of the longest isoform is suggested to be capable of inhibiting the Wnt/β-catenin signaling network. This study utilized several genetically modified mouse lines and electron microscopy to achieve new information on the biological role of collagen XVIII, its different isoforms, and the frizzled domain. Lack of collagen XVIII was found to affect the integrity of basement membr

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46

Fowler, Susan J. "Molecular analysis of glucose-induced basement membrane thickening in hydra vulgaris : a non-mammalian model for diabetic microangiopathy." Thesis, University of Manchester, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706484.

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47

Glentis, Alexandros. "Le rôle des fibroblastes associés aux carcinomes dans l’invasion de la membrane basale par les cellules cancéreuses." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066452.

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La membrane basale (BM) constitue une barrière physiologique entre les tissus et leur microenvironnement. Dans le cas des cancers épithéliaux, au stade de carcinome invasif, la membrane basale est compromise et les cellules cancéreuses envahissent le stroma. Dans cette thèse de doctorat, j’ai proposé d’étudier l’invasion de la membrane basale par les cellules cancéreuses et comment une population de cellules stromales, les fibroblastes, affectent cette invasion. Dans le cadre de cette étude, nous avons utilisé le modèle du cancer colorectal. En collaboration avec l’hôpital Curie, nous avons is

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48

Mazariegos, Mario Rolando. "Biogenesis of basement membrane components by the endodermal cells of the rat parietal yolk sac as studied by radioautography." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66113.

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49

Mohamed, Alahlafi Abdelaziz H. "The significance of immune reactants deposited in the basement membrane zone of the skin in patients with lupus erythematosus." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275408.

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50

Powers, Nathan Anthony. "Involvement of JAK/STAT Signaling and a Basement Membrane-Associated Protein during Air Sac Primordium Development in Drosophila Melanogaster." TopSCHOLAR®, 2018. https://digitalcommons.wku.edu/theses/3089.

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Tumor metastasis currently presents the greatest obstacle for effective cancer remediation. Metastatic growth necessitates both degradation of a specialized form of extracellular matrix (ECM) known as the basement membrane (BM) and the invasion of surrounding tissues thereafter. The thoracic air sacs of fruit flies (Drosophila melanogaster), which develop and operate in a fashion comparable to the human lung, provide a unique model for identifying and characterizing factors that contribute to its own development as well as tumoral invasion. We investigated the involvement of both Janus kinase

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