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Rozprawy doktorskie na temat „Membrane proteins”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Gill, Katrina Louise. "Protein-protein interactions in membrane proteins." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400016.

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2

Hedin, Linnea E., Kristoffer Illergård, and Arne Elofsson. "An Introduction to Membrane Proteins." Stockholms universitet, Institutionen för biokemi och biofysik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-69241.

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alpha-Helical membrane proteins are important for many biological functions. Due to physicochemical constraints, the structures of membrane proteins differ from the structure of soluble proteins. Historically, membrane protein structures were assumed to be more or less two-dimensional, consisting of long, straight, membrane-spanning parallel helices packed against each other. However, during the past decade, a number of the new membrane protein structures cast doubt on this notion. Today, it is evident that the structures of many membrane proteins are equally complex as for many soluble protei

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3

Kota, Jhansi. "Membrane chaperones : protein folding in the ER membrane /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-102-9/.

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4

Whitehead, L. "Computer simulation of biological membranes and membrane bound proteins." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297412.

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5

Armstrong, James P. "Artificial membrane-binding proteins." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.686615.

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Membrane functionalization is a promising strategy for augmenting cell performance in regenerative medicine. To this end, the design, construction, characterisation and cell affinity of protein-polymer surfactant nanoconstructs are presented. Nanoconstructs of eGFP were synthesised that exhibited near-native structure and function, as well as effective and persistent membrane affinity. Human mesenchymal stem cells were labelled for up to ten days in culture, without affecting cell viability or differentiation capacity. This "cell priming" technology has been used to address the issue of hypoxi

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6

Zhang, Xiao Xiao. "Identification of membrane-interacting proteins and membrane protein interactomes using Nanodiscs and proteomics." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/39413.

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The insoluble nature of membrane proteins has complicated the identification of their interactomes. The Nanodisc has allowed the membrane and membrane proteins to exist in a soluble state. In this thesis, we combined Nanodisc and proteomics and applied the technique to discover the interactome of membrane proteins. Using the SecYEG and MalFGK membrane complex incorporated into Nanodisc, we identified, Syd, SecA, and MalE. These interactions were identified with high specificity and confidence from total soluble protein extracts. The protein YidC was also tested but no interactors were detected

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7

Josyula, Ratnakar. "Structural studies of yeast mitochondrial peripheral membrane protein TIM44." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/josyula.pdf.

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8

Rapp, Mikaela. "The Ins and Outs of Membrane Proteins : Topology Studies of Bacterial Membrane Proteins." Doctoral thesis, Stockholm : Department of Biochemistry and Biophysics, Stockholm University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1330.

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9

Berger, Bryan William. "Protein-surfactant solution thermodynamics applications to integral membrane proteins /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 15.42 Mb., 304 p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3200533.

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10

Keegan, Neil. "From engineered membrane proteins to self-assembling protein monolayers." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419991.

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11

Stewart, Christine Catherine. "Toxicity of mutant membrane proteins /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/10259.

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12

Ye, Cui. "STABILITY STUDIES OF MEMBRANE PROTEINS." UKnowledge, 2014. http://uknowledge.uky.edu/chemistry_etds/33.

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The World Health Organization has identified antimicrobial resistance as one of the top three threats to human health. Gram-negative bacteria such as Escherichia coli are intrinsically more resistant to antimicrobials. There are very few drugs either on the market or in the pharmaceutical pipeline targeting Gram-negative pathogens. Two mechanisms, the protection of the outer membrane and the active efflux by the multidrug transporters, play important roles in conferring multidrug resistance to Gram-negative bacteria. My work focuses on two main directions, each aligning with one of the known m

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13

Duncan, Anna Louise. "Coarse-grained molecular dynamics simulations of mitochondrial membrane proteins." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648455.

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14

Ulmschneider, Martin B. "Computational studies of membrane proteins." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249198.

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15

Chalton, David Allen. "Engineering of outer membrane proteins." Thesis, University of Newcastle Upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430336.

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16

Fearnley, I. M. "Studies of mitochondrial membrane proteins." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380262.

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17

Wahba, Karim A. "Statistical mechanics of membrane proteins." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1905048771&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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18

Lee, Chongsoo. "Raman spectroscopy of supported lipid bilayers and membrane proteins." Thesis, University of Oxford, 2005. http://ora.ox.ac.uk/objects/uuid:76f4be6e-b7d3-46c5-a2a1-3dcc7a399410.

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Off-resonance unenhanced total internal reflection (TIR) Raman Spectroscopy was explored to investigate supported single lipid bilayers with incorporated membrane peptides/proteins at water/solid interface. A model membrane was formed on a planar supported lipid layer (pslb) by the fusion of the reconstituted small unilamellar vesicles (SUVs), and the intensity of bilayer was confirmed by a comparison of Raman spectral intensity in the C-H stretching modes with C<sub>16</sub>TAB. With prominent Raman sensitivity attained, we studied the 2-D phase transition of DMPC and DPPC pslbs and the tempe

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19

Guseva, Ksenia. "Formation and cooperative behaviour of protein complexes on the cell membrane." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203444.

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In this work we analyse aspects of dynamics and organization of biological membranes from a physical prospective [i.e. perspective]. We provide an analysis of the process of self-assembly and spatial organization of membrane proteins. We illustrate the analysis by considering a channel activated by membrane tension called mechanosensitive channels (MS), in E. coli and the twin arginine translocation system (Tat). We analyse the mechanism of formation of oligomeric protein complexes formed by identical subunits. By derivation of a mathematical approach based on Smoluchowski coagulation equation

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20

Stubberfield, Lisa Marie. "Interactions of Plasmodium falciparum proteins at the membrane skeleton of infected erythrocytes." Monash University, Dept. of Microbiology, 2003. http://arrow.monash.edu.au/hdl/1959.1/9433.

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21

LADHA, PARAG. "POLYMERIC MEMBRANE SUPPORTED BILAYER LIPID MEMBRANES RECONSTITUTED WITH BIOLOGICAL TRANSPORT PROTEINS." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1145901880.

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22

Cohen, Alona. "Studies of regulated membrane trafficking /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1634379741&sid=7&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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23

Oldham, Alexis Jean. "Modulation of lipid domain formation in mixed model systems by proteins and peptides." View electronic thesis, 2008. http://dl.uncw.edu/etd/2008-1/r1/oldhama/alexisoldham.pdf.

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24

Nilsson, Johan. "Membrane protein topology : prediction, experimental mapping and genome-wide analysis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-963-3/.

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25

Boulter, Jonathan Michael. "Structural and functional studies of the erythrocyte anion exchanger, band 3." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297079.

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26

Francisco, Rafael Neves. "Solubilization of membrane proteins using ionic liquids." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/21537.

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Mestrado em Biotecnologia, ramo biotecnologia industrial e ambiental<br>The main goal of this work consists on the study of the ability of ionic liquids (ILs) to extract membrane proteins from biological membranes while keeping their integrity in aqeuous solutions. Since typical surfactants are mainly used for this purpose, ILs are here investigated as a new class of extraction agents. For the evaluation of the ILs solvation ability power, four proteins were selected to be overexpressed in Escherichia coli and to be used as model proteins, namely the Outer Membrane Protein F (OmpF) and Outer

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27

Shinohara, Elvira Maria Guerra. "Estudo das proteínas da membrana eritrocitária de mamíferos de treze ordens da classe mammalia." Universidade de São Paulo, 1996. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-28042008-122838/.

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Foram estudadas as proteínas da membrana eritrocitária de quarenta e seis espécies diferentes pertencentes à treze ordens da classe Mammalia, através de eletroforese em gel de poliacrilamida. Observamos que: 1. não parece haver correlação entre as concentrações relativas de espectrinas e o volume corpuscular médio. 2. não parece haver correlação entre as concentrações relativas de banda 3 e o volume corpuscular médio. 3. parece haver uma correlação inversa entre as concentrações relativas das anquirinas e o volume corpuscular médio. Assim, a maior parte dos animais pertencentes à ordem dos Art

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28

Carlisle, Glenn E. "Characterization of Mycobacterium avium cytoplasmic membrane proteins with an emphasis on the major cytoplasmic membrane protein." Thesis, Virginia Tech, 1991. http://hdl.handle.net/10919/42610.

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Proteins of the cytoplasmic membrane of Mycobacterium avium were investigated to identify those which were: (1)intrinsic or extrinsic, (2) attached to the cell wall, (3)surface accessible and (4) excreted. In addition sera containing anti-cytoplasmic membrane proteins were obtained and preliminary purification of the cytoplasmic membrane protein was attempted. The predominating cytoplasmic membrane protein of 31,000 daltons (MCMP) was found to be intrinsic, attached to the cell wall and possibly surface accessible. The MCMP was not excreted, even in media in which the MCMP is not found in the

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29

Marchand, Petra. "Structure, membrane association, and processing of meprin subunits." Diss., This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-06062008-171918/.

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30

Boban, Mirta. "Transcriptional regulation by inner nuclear membrane proteins /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-170-8/.

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31

Almqvist, Jonas. "Structural modeling of membrane transporter proteins /." Stockholm : Department of Physical, Inorganic and Structural Chemistry, Stockholm University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7402.

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32

Cox, Katherine L. "Molecular dynamics of outer membrane proteins." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427881.

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33

Crooks, Kim Chantelle. "Turnover of plant plasma membrane proteins." Thesis, Oxford Brookes University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363720.

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34

Kulkarni, Chandrashekhar V. "In-Cubo Crystallization of Membrane Proteins." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508495.

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35

Folea, Ioana Mihaela. "Electron microscopy of cyanobacterial membrane proteins." [S.l. : [Groningen : s.n.] ; University of Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/314679286.

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36

Boekel, Carolina. "Integration and topology of membrane proteins." Doctoral thesis, Stockholm : Department of Biochemistry and Biophysics, Stockholm University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8575.

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37

Lüthy, Roland. "Proteins involved in membrane transfer processes /." [S.l : s.n.], 1988. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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38

Kochva, Uzi. "Structural analysis of integral membrane proteins." E-thesis Full text (Hebrew University users only), 2007. http://shemer.mslib.huji.ac.il/dissertations/H/JSL/001449168.pdf.

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39

Saleem, Muhammad. "Structural studies of prokaryotic membrane proteins." Thesis, University of Manchester, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492047.

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40

Polozov, Ivan V. "Interactions of class A and class L amphipathic helical peptides with model membranes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0006/NQ30110.pdf.

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41

Tuan, Chik Syed Mohd Saufi. "Mixed Matrix Membrane Chromatography for Bovine Whey Protein Fractionation." Thesis, University of Canterbury. Chemical and Process Engineering, 2010. http://hdl.handle.net/10092/3647.

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Whey protein fractionation is an important industrial process that requires effective large-scale processes. Although packed bed chromatography has been used extensively, it suffers from low processing rates due to high back-pressures generated at high flow rates. Batch chromatography has been applied but generally has a low efficiency. More recently, adsorptive membranes have shown great promise for large-scale protein purification, particularly from large-volume dilute feedstocks. A new method for producing versatile adsorptive membranes by combining membrane and chromatographic resin matric

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42

Höglund, Pär J. "Identification, Characterization and Evolution of Membrane-bound Proteins /." Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9329.

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43

Howard, Megan Wilder. "Coronavirus mediated membrane fusion /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008. http://proquest.umi.com/pqdweb?did=1552538711&sid=1&Fmt=6&clientId=18952&RQT=309&VName=PQD.

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Thesis (Ph.D. in Microbiology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 161-183). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

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44

Pothakanoori, Kapil. "A Web Service for Protein Refinement and Refinement of Membrane Proteins." ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/102.

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The structures obtained from homology modeling methods are of intermediate resolution 1-3Ã… from true structure. Energy minimization methods allow us to refine the proteins and obtain native like structures. Previous work shows that some of these methods performed well on soluble proteins. So we extended this work on membrane proteins. Prediction of membrane protein structures is a particularly important, since they are important biological drug targets, and since their number is vanishingly small, as a result of the inherent difficulties in working with these molecules experimentally. Hence t

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45

Krammer, André Thomas. "Computational studies of protein-membrane interactions and forced unfolding of proteins /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/9697.

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46

Cao, Liming. "Protein Separation with Ion-exchange Membrane Chromatography." Link to electronic thesis, 2005. http://www.wpi.edu/Pubs/ETD/Available/etd-050405-174109/.

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47

Björkholm, Patrik. "Protein Interactions from the Molecular to the Domain Level." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-101795.

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The basic unit of life is the cell, from single-cell bacteria to the largest creatures on the planet. All cells have DNA, which contains the blueprint for proteins. This information is transported in the form of messenger RNA from the genome to ribosomes where proteins are produced. Proteins are the main functional constituents of the cell, they usually have one or several functions and are the main actors in almost all essential biological processes. Proteins are what make the cell alive. Proteins are found as solitary units or as part of large complexes. Proteins can be found in all parts of

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48

Tsui, Marco Man Kin. "Studies on yeast SNARE complex formation /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202003%20TSUI.

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Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 130-138). Also available in electronic version. Access restricted to campus users.

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49

Mayol, Escuer Eduardo. "Development of bioinformatic tools for the study of membrane proteins." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667335.

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Las proteínas de membrana son elementos fundamentales de todas las células conocidas, que representan una cuarta parte de los genes del genoma humano, y desempeñan funciones esenciales en la biología celular. Alrededor del 50% de los medicamentos comercializados actualmente tienen una proteína de membrana como objetivo, y alrededor de un tercio de todos ellos se dirigen a los receptores acoplados a proteína G (GPCR). Las dificultades y limitaciones en el trabajo experimental necesario para los estudios microscópicos de la membrana, así como las proteínas de membrana, impulsaron el uso de métod

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50

Käll, Lukas. "Predicting transmembrane topology and signal peptides with hidden Markov models /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-719-7/.

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