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Artykuły w czasopismach na temat „Metalloproteinases Inhibitors Therapeutic use”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 28 stycznia 2023

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1

Ganea, E., M. Trifan, A. C. Laslo, G. Putina, and C. Cristescu. "Matrix metalloproteinases: useful and deleterious." Biochemical Society Transactions 35, no. 4 (July 20, 2007): 689–91. http://dx.doi.org/10.1042/bst0350689.

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MMPs (matrix metalloproteinases) are zinc-dependent endopeptidases that degrade both matrix and non-matrix proteins. They play an important role in morphogenesis, and in a wide range of processes including tissue repair and remodelling. Their abnormal expression contributes to pathological processes including arthritis, cancer, and cardiac and central nervous system diseases, which explains the large interest in finding specific MMP inhibitors for therapeutic use. In this review we describe the structural features of MMPs, with special emphasis on their interaction with specific inhibitors. Th

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Jakubowska, Katarzyna, Anna Pryczynicz, Piotr Iwanowicz, Andrzej Niewiński, Elżbieta Maciorkowska, Jerzy Hapanowicz, Dorota Jagodzińska, Andrzej Kemona, and Katarzyna Guzińska-Ustymowicz. "Expressions of Matrix Metalloproteinases (MMP-2, MMP-7, and MMP-9) and Their Inhibitors (TIMP-1, TIMP-2) in Inflammatory Bowel Diseases." Gastroenterology Research and Practice 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/2456179.

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Crohn’s disease (CD) and ulcerative colitis (UC) belong to a group of inflammatory bowel diseases (IBD). The aim of our study was to evaluate the expression of MMP-2, MMP-7, MMP-9, TIMP-1, and TIMP-2 in ulcerative colitis and Crohn’s disease. The study group comprised 34 patients with UC and 10 patients with CD. Evaluation of MMP-2, MMP-7, MMP-9, TIMP-1, and TIMP-2 expression in tissue samples was performed using immunohistochemistry. The overexpression of MMP-9 and TIMP-1 was dominant in both the glandular epithelium and inflammatory infiltration in UC patients. In contrast, in CD subjects th

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De, S., J. E. Fenton, and A. S. Jones. "Matrix metalloproteinases and their inhibitors in non-neoplastic otorhinolaryngological disease." Journal of Laryngology & Otology 119, no. 6 (June 2005): 436–42. http://dx.doi.org/10.1258/0022215054273269.

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Matrix metalloproteinases (MMPs) are a family of zinc and calcium-dependent endopeptidases that play a key role in extracellular matrix (ECM) degradation. MMPs are known to be important in normal remodelling processes. Overexpression and activation of MMPs or an imbalance of active MMPs and tissue inhibitors of metalloproteinases (TIMPs) has been linked with a number of specific disease states associated with the breakdown and remodelling of the extracellular matrix. MMPs and TIMPs play a role in the development and progression of conditions such as acute and chronic otitis media, nasal polypo

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Titovska, S. O. "EFFECTIVENESS OF MATRIX METALLOPROTEINASES INHIBITORS FOR PREVENTIVE TREATMENT OF GENERALIZED PERIODONTITIS." Ukrainian Dental Almanac, no. 2 (June 27, 2022): 10–15. http://dx.doi.org/10.31718/2409-0255.2.2022.02.

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Generalized periodontitis is one of the most widespread human stomatological diseases; it is diagnosed in 11.0 % of the world's population. Despite the recognition of the microbial factor as leading in its etiopathogenesis, antimicrobial treatment of gingivitis, added with removal of dental plaque, does not prevent the further development of periodontitis. Dysbacteriosis causes inflammation which leads to an increase of proteolysis products. They are a nutrient medium for periodontal pathogenic microflora, they contribute to its growth. So, the use of anti-inflammatory drugs, such as matrix me

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Beletskaya, Inessa Stanislavovna, and Sergey Yurievich Astakhov. "The role of matrix metalloproteinases in glaucoma pathogenesis." Ophthalmology journal 8, no. 3 (December 15, 2015): 28–43. http://dx.doi.org/10.17816/ov2015328-43.

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Matrix metalloproteinases belong to an enzyme family, which assure a proteolysis of practically all components of the extracellular matrix of connective tissues in normal and pathological conditions. At physiological conditions, there are evidences on the impact of this enzyme group in the embryogenesis, morphogenesis, angiogenesis, and tissue involution. The activity impairment of matrix metalloproteinases and of their specific inhibitors leads to the biosynthesis misbalance and to the degradation of extracellular matrix components; it plays a role in the development of such diseases as diabe

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Docherty, Andy J., Tom Crabbe, James P. O'Connell, and Colin R. Groom. "Proteases as drug targets." Biochemical Society Symposia 70 (September 1, 2003): 147–61. http://dx.doi.org/10.1042/bss0700147.

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The effective management of AIDS with HIV protease inhibitors, or the use of angiotensin-converting enzyme inhibitors to treat hypertension, indicates that proteases do make good drug targets. On the other hand, matrix metalloproteinase (MMP) inhibitors from several companies have failed in both cancer and rheumatoid arthritis clinical trials. Mindful of the MMP inhibitor experience, this chapter explores how tractable proteases are as drug targets from a chemistry perspective. It examines the recent success of other classes of drug for the treatment of rheumatoid arthritis, and highlights the

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Elgezawi, Moataz, Rasha Haridy, Khalid Almas, Moamen A. Abdalla, Omar Omar, Hatem Abuohashish, Abeer Elembaby, Uta Christine Wölfle, Yasir Siddiqui, and Dalia Kaisarly. "Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects." International Journal of Molecular Sciences 23, no. 16 (August 11, 2022): 8929. http://dx.doi.org/10.3390/ijms23168929.

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Objectives: This review article aims to describe some of the roles of Matrix metalloproteinases (MMPs) in enamel, dentine, dental caries, hybrid layer degradation, pulp and periodontal tissues, throwing light on their current inhibitors. The article addresses the potential of MMPs to serve as biomarkers with diagnostic and therapeutic value. Design: The sections of this review discuss MMPs’ involvement in developmental, remodeling, degradational and turnover aspects of dental and periodontal tissues as well as their signals in the pathogenesis, progress of different lesions and wound healing o

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Doll, Carla U., Sabine Niebert, and Janina Burk. "Mesenchymal Stromal Cells Adapt to Chronic Tendon Disease Environment with an Initial Reduction in Matrix Remodeling." International Journal of Molecular Sciences 22, no. 23 (November 26, 2021): 12798. http://dx.doi.org/10.3390/ijms222312798.

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Tendon lesions are common sporting injuries in humans and horses alike. The healing process of acute tendon lesions frequently results in fibrosis and chronic disease. In horses, local mesenchymal stromal cell (MSC) injection is an accepted therapeutic strategy with positive influence on acute lesions. Concerning the use of MSCs in chronic tendon disease, data are scarce but suggest less therapeutic benefit. However, it has been shown that MSCs can have a positive effect on fibrotic tissue. Therefore, we aimed to elucidate the interplay of MSCs and healthy or chronically diseased tendon matrix

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Cho, Chul-Hyun, Kwang-Soon Song, Beom-Soo Kim, Du Hwan Kim, and Yun-Mee Lho. "Biological Aspect of Pathophysiology for Frozen Shoulder." BioMed Research International 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/7274517.

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It is fairly well understood that frozen shoulder involves several stages, which reflect the series of process from capsular inflammation and fibrosis to spontaneous resolution of this fibrosis. However, the underlying pathophysiologic process remains poorly determined. For this reason, management of frozen shoulder remains controversial. Determining the pathophysiological processes of frozen shoulder is a pivotal milestone in the development of novel treatment for patients with frozen shoulder. This article reviews what is known to date about the biological pathophysiology of frozen shoulder.

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Laghezza, Antonio, Luca Piemontese, Leonardo Brunetti, Alessia Caradonna, Mariangela Agamennone, Fulvio Loiodice, and Paolo Tortorella. "(2-Aminobenzothiazole)-Methyl-1,1-Bisphosphonic Acids: Targeting Matrix Metalloproteinase 13 Inhibition to the Bone." Pharmaceuticals 14, no. 2 (January 24, 2021): 85. http://dx.doi.org/10.3390/ph14020085.

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Matrix Metalloproteinases (MMPs) are a family of secreted and membrane-bound enzymes, of which 24 isoforms are known in humans. These enzymes degrade the proteins of the extracellular matrix and play a role of utmost importance in the physiological remodeling of all tissues. However, certain MMPs, such as MMP-2, -9, and -13, can be overexpressed in pathological states, including cancer and metastasis. Consequently, the development of MMP inhibitors (MMPIs) has been explored for a long time as a strategy to prevent and hinder metastatic growth, but the important side effects linked to promiscuo

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11

Rangasamy, Geronimo, Ortín, Coderch, Zapico, Ramos, and de Pascual-Teresa. "Molecular Imaging Probes Based on Matrix Metalloproteinase Inhibitors (MMPIs)." Molecules 24, no. 16 (August 16, 2019): 2982. http://dx.doi.org/10.3390/molecules24162982.

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Matrix metalloproteinases (MMPs) are a family of zinc- and calcium-dependent endopeptidases which are secreted or anchored in the cell membrane and are capable of degrading the multiple components of the extracellular matrix (ECM). MMPs are frequently overexpressed or highly activated in numerous human diseases. Owing to the important role of MMPs in human diseases, many MMP inhibitors (MMPIs) have been developed as novel therapeutics, and some of them have entered clinical trials. However, so far, only one MMPI (doxycycline) has been approved by the FDA. Therefore, the evaluation of the activ

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12

Janowska-Wieczorek, A., Leah A. Marquez-Curtis, Kenton Gan, Loree Larratt та Anthony Woods. "TNF-α Stimulates Matrix Metalloproteinase Expression in Myelodysplastic Syndromes (MDS): Therapeutic Potential for Inhibitors of TNF-α and MMPs." Blood 106, № 11 (16 листопада 2005): 3447. http://dx.doi.org/10.1182/blood.v106.11.3447.3447.

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Abstract MDS is characterized by ineffective hematopoiesis with increased intramedullary apoptosis which has been correlated in turn with high levels of tumor necrosis factor (TNF)- α. Previously, we showed that TNF-α strongly upregulates the secretion of the matrix metalloproteinases (MMP)-2 and -9 in normal CD34+ cells. Elevated expression of MMPs has been suggested to contribute to cancer progression and leukemic dissemination and MMPs also facilitate the secretion of TNF-α. In this work, we hypothesized that TNF-α-induced MMP production plays a role in the progression of MDS. We therefore

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Davis, Max E., Jonathan P. Gumucio, Kristoffer B. Sugg, Asheesh Bedi, and Christopher L. Mendias. "MMP inhibition as a potential method to augment the healing of skeletal muscle and tendon extracellular matrix." Journal of Applied Physiology 115, no. 6 (September 15, 2013): 884–91. http://dx.doi.org/10.1152/japplphysiol.00137.2013.

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The extracellular matrix (ECM) of skeletal muscle and tendon is composed of different types of collagen molecules that play important roles in the transmission of forces throughout the body, and in the repair and regeneration of injured tissues. Fibroblasts are the primary cells in muscle and tendon that maintain, repair, and modify the ECM in response to mechanical loading, injury, and inactivity. Matrix metalloproteinases (MMPs) are enzymes that digest collagen and other structural molecules, which are synthesized and excreted by fibroblasts. MMPs are required for baseline ECM homeostasis, b

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Qiu, Zheng, Jianghai Chen, Hanmei Xu, Philippe E. Van den Steen, Ghislain Opdenakker, Min Wang, and Jialiang Hu. "Inhibition of Neutrophil Collagenase/MMP-8 and Gelatinase B/MMP-9 and Protection against Endotoxin Shock." Journal of Immunology Research 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/747426.

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Endotoxin shock is a life-threatening disorder, associated with the rapid release of neutrophil enzymes, including neutrophil collagenase/matrix metalloproteinase-8 (MMP-8) and gelatinase B/matrix metalloproteinase-9 (MMP-9). After activation, these enzymes cleave extracellular matrix components and cytokines and thus may contribute to shock syndrome development. MMP inhibitors have been suggested as immunotherapy of endotoxin shock. However, little is known about the therapeutic time window of MMP inhibition. Here, a sublethal endotoxin shock mouse model was used to evaluate the effect of an

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15

Bai, Qian, Mengzhou Xue, and V. Wee Yong. "Microglia and macrophage phenotypes in intracerebral haemorrhage injury: therapeutic opportunities." Brain 143, no. 5 (January 9, 2020): 1297–314. http://dx.doi.org/10.1093/brain/awz393.

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Abstract The prognosis of intracerebral haemorrhage continues to be devastating despite much research into this condition. A prominent feature of intracerebral haemorrhage is neuroinflammation, particularly the excessive representation of pro-inflammatory CNS-intrinsic microglia and monocyte-derived macrophages that infiltrate from the circulation. The pro-inflammatory microglia/macrophages produce injury-enhancing factors, including inflammatory cytokines, matrix metalloproteinases and reactive oxygen species. Conversely, the regulatory microglia/macrophages with potential reparative and anti

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Purcell, Brendan P., Shayne C. Barlow, Paige E. Perreault, Lisa Freeburg, Heather Doviak, Julia Jacobs, Abigail Hoenes, et al. "Delivery of a matrix metalloproteinase-responsive hydrogel releasing TIMP-3 after myocardial infarction: effects on left ventricular remodeling." American Journal of Physiology-Heart and Circulatory Physiology 315, no. 4 (October 1, 2018): H814—H825. http://dx.doi.org/10.1152/ajpheart.00076.2018.

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Although improvements in timing and approach for early reperfusion with acute coronary syndromes have occurred, myocardial injury culminating in a myocardial infarction (MI) remains a common event. Although a multifactorial process, an imbalance between the induction of proteolytic pathways, such as matrix metalloproteinases (MMPs) and endogenous tissue inhibitors of metalloproteinase (TIMPs), has been shown to contribute to this process. In the present study, a full-length TIMP-3 recombinant protein (rTIMP-3) was encapsulated in a specifically formulated hyaluronic acid (HA)-based hydrogel th

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17

Xie, Chunfang, Laura-Oana Albulescu, Mátyás A. Bittenbinder, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, and Jeroen Kool. "Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins." Biomedicines 8, no. 9 (August 20, 2020): 297. http://dx.doi.org/10.3390/biomedicines8090297.

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Animal-derived antivenoms are the only specific therapies currently available for the treatment of snake envenoming, but these products have a number of limitations associated with their efficacy, safety and affordability for use in tropical snakebite victims. Small molecule drugs and drug candidates are regarded as promising alternatives for filling the critical therapeutic gap between snake envenoming and effective treatment. In this study, by using an advanced analytical technique that combines chromatography, mass spectrometry and bioassaying, we investigated the effect of several small mo

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Fisher, Courtney L., and Stacie L. Demel. "Nonsteroidal Anti-Inflammatory Drugs: A Potential Pharmacological Treatment for Intracranial Aneurysm." Cerebrovascular Diseases Extra 9, no. 1 (April 30, 2019): 31–45. http://dx.doi.org/10.1159/000499077.

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Background: Saccular intracranial aneurysms (IAs) are outpouchings of the vessel wall of intracranial arteries. Rupture of IAs results in subarachnoid hemorrhage which is associated with high morbidity and mortality. Surgical interventions, such as clipping and coiling, have associated risks. Currently, there are no proven pharmacological treatments to prevent the growth or rupture of IAs. Infiltration of proinflammatory cytokines in response to increased wall sheer stress is a hallmark of IA. Nonsteroidal anti-inflammatory drugs (NSAIDs) are being investigated as potential therapeutic agents

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Sato, Aki, Yoshihiko Tashiro, Chiemi Nishida, Ismael Gritli, Kaori Kusubata, Satoshi Takahashi, Beate Heissig, Koichi Hattori, and Hiromitsu Nakauchi. "A Plasmin Inhibitor Prevents Lethal Acute Graft-Versus-Host Disease in Mice." Blood 118, no. 21 (November 18, 2011): 1897. http://dx.doi.org/10.1182/blood.v118.21.1897.1897.

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Abstract Abstract 1897 Proinflammatory cytokines released upon cell damage can cause excessive tissue destruction in acute graft-versus-host disease (GVHD). Certain key cytokines for GVHD like TNF-α and Fas-ligand, are secreted by ectodomain shedding from matrix metalloproteinases (MMPs). Many MMP inhibitors have been developed and used over the last three or four decades, but its widespread use is hampered by severe side effects. We reported that the fibrinolytic system, above all plasmin formation promotes the activation of several MMPs. Therefore we hypothesized that plasmin inhibition migh

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Wang, Dan-Dan, Wen-Xiu Xu, Wen-Quan Chen, Lei Li, Su-Jin Yang, Jian Zhang, and Jin-Hai Tang. "Identification of TIMP2 as a Prognostic Biomarker and Its Correlation with Tumor Immune Microenvironment: A Comprehensive Pan-Cancer Analysis." Journal of Oncology 2022 (October 18, 2022): 1–12. http://dx.doi.org/10.1155/2022/9133636.

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Background. Tissue inhibitor of metalloproteinase-2 (TIMP2), an endogenous inhibitor of matrix metalloproteinases, has been disclosed to participate in the development and carcinogenesis of multiple malignancies. However, the prognosis of TIMP2 in different cancers and its correlation with tumor microenvironment and immunity have not been clarified. Methods. In this study, we conducted a comprehensive bioinformatics analysis to evaluate the prognostic and therapeutic value of TIMP2 in cancer patients by utilizing a series of databases, including Oncomine, GEPIA, cBioPortal, GeneMANIA, Metascap

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Castellazzi, Massimiliano, Tiziana Bellini, Alessandro Trentini, Serena Delbue, Francesca Elia, Matteo Gastaldi, Diego Franciotta, et al. "Serum Gelatinases Levels in Multiple Sclerosis Patients during 21 Months of Natalizumab Therapy." Disease Markers 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/8434209.

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Background. Natalizumab is a highly effective treatment approved for multiple sclerosis (MS). The opening of the blood-brain barrier mediated by matrix metalloproteinases (MMPs) is considered a crucial step in MS pathogenesis. Our goal was to verify the utility of serum levels of active MMP-2 and MMP-9 as biomarkers in twenty MS patients treated with Natalizumab.Methods. Serum levels of active MMP-2 and MMP-9 and of specific tissue inhibitors TIMP-1 and TIMP-2 were determined before treatment and for 21 months of therapy.Results. Serum levels of active MMP-2 and MMP-9 and of TIMP-1 and TIMP-2

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Saleh, Samar R., Rana Attia, and Doaa A. Ghareeb. "The Ameliorating Effect of Berberine-Rich Fraction against Gossypol-Induced Testicular Inflammation and Oxidative Stress." Oxidative Medicine and Cellular Longevity 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/1056173.

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This study was aimed at evaluating the efficacy of berberine-rich fraction (BF) as a protective and/or a therapeutic agent against inflammation and oxidative stress during male infertility. Sexually mature Sprague-Dawley male rats were divided into five groups treated with either corn oil, BF (100 mg/kg BW, orally, daily for 30 days), gossypol acetate (5 mg/kg BW, i.p.) eight times for 16 days, BF alone for 14 days then coadministered with gossypol acetate for the next 16 days (protected group), or gossypol acetate for 16 days then treated with BF for 30 days (treated group). All animals compl

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Galm, Oliver, Edgar Jost, Claudia Schubert, James G. Herman, Tim H. Brümmendorf, and Stefan Wilop. "Epigenetic Dysregulation of the Tissue Inhibitor of Metalloproteinases-2 Gene in Multiple Myeloma." Blood 118, no. 21 (November 18, 2011): 5089. http://dx.doi.org/10.1182/blood.v118.21.5089.5089.

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Abstract Abstract 5089 Background: Multiple myeloma (MM) is a B-cell neoplasm characterized by the accumulation of malignant plasma cells in the bone marrow (BM) as well as abundant BM angiogenesis. Aberrant methylation of CpG islands near gene promoter regions is the most widely studied epigenetic abnormality in human malignancies and is associated with loss of gene expression. There is increasing evidence for a role of the tissue inhibitor of metalloproteinases 2 (TIMP2) gene as a tumor suppressor. Overexpression of TIMP2 may result in decreased invasive potential, suppression of tumor growt

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Barrows, Brad D., and Jun Teruya. "Use of the ADAMTS13 Activity Assay Improved the Accuracy and Efficiency of the Diagnosis and Treatment of Suspected Acquired Thrombotic Thrombocytopenic Purpura." Archives of Pathology & Laboratory Medicine 138, no. 4 (April 1, 2014): 546–49. http://dx.doi.org/10.5858/arpa.2013-0170-oa.

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Context.—Acquired thrombotic thrombocytopenic purpura (A-TTP) is a rare but significant disease requiring rapid diagnosis and treatment. The diagnosis is often difficult because of variability in the presence of specific clinical criteria. The primary etiology of A-TTP involves inhibitors directed against ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13). Literature has shown that the ADAMTS13 activity assay is sensitive and specific for identifying cases of A-TTP, and application of this test as an on-site screening method has not been fully explored

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Majumder, Romit, Madhuri Datta, Aindrila Chattopadhyay, and Debasish Bandyopadhyay. "Melatonin promotes gastric healing by modulating the components of matrix metalloproteinase signaling pathway: a novel scenario for gastric ulcer management." Melatonin Research 4, no. 2 (March 30, 2021): 213–31. http://dx.doi.org/10.32794/mr11250092.

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Over the past few decades, since the induction of antibiotics and proton pump inhibitors (PPI) as a therapeutic tool in controlling gastropathy, a substantial decline in the incidence of gastric ulcer and its related manifestations has been achieved globally. However, there are a lot of skeptics on the steady rise in the list of complications following long-term use of these drugs, especially in chronic and elderly patients. Hence, the search for a sustainable cure for these gastropathies has never actually ended; this let us consider that melatonin, an endogenous antioxidant, might have a uti

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El-Baz, Farouk K., Abeer Salama та Rania A. A. Salama. "Therapeutic Effect of Dunaliella salina Microalgae on Thioacetamide- (TAA-) Induced Hepatic Liver Fibrosis in Rats: Role of TGF-β and MMP9". BioMed Research International 2019 (24 вересня 2019): 1–9. http://dx.doi.org/10.1155/2019/7028314.

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Liver fibrosis represents a serious global health-care problem and is the outcome of many chronic liver diseases, cirrhosis, hepatitis, and toxin accumulation. The present study aimed to evaluate the antifibrotic curative effect of Dunaliella salina (D. salina) on thioacetamide- (TAA-) induced liver fibrosis in rats. Liver fibrosis was induced by TAA (200mg/kg; i.p.) twice per week for 6 weeks. D. salina was given orally (100 and 200 mg/kg) and silymarin was given orally (100 mg/kg) daily, for 4 weeks after TAA. Serum transaminase activities, liver inflammatory cytokines, fibrotic biomarkers,

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Taherkhani, Amir, Athena Orangi, Shirin Moradkhani, Alireza Jalalvand, and Zahra Khamverdi. "Identification of Potential Anti-tooth-decay Compounds From Organic Cinnamic Acid Derivatives by Inhibiting Matrix Metalloproteinase-8: An In Silico Study." Avicenna Journal of Dental Research 14, no. 1 (March 29, 2022): 25–32. http://dx.doi.org/10.34172/ajdr.2022.05.

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Background: Matrix metalloproteinase-8 (MMP-8) is the most abundant member of the MMP family in human dentin. It takes a part in the normal physiology of tissue remodeling and wound healing, while the overexpression/hyperactivity of this protein leads to several oral disorders, including dental caries and peri-implant inflammation/diseases, and therefore, MMP-8 inhibition may have therapeutic effects. Accordingly, the current study aimed to identify potential MMP-8 inhibitors from cinnamic acid derivatives. Methods: The binding affinity of cinnamic acid and its several derivatives to the MMP-8

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Brune, Kay, Hugo A. Katus, Joachim Moecks, Eberhard Spanuth, Allan S. Jaffe, and Evangelos Giannitsis. "N-Terminal Pro–B-Type Natriuretic Peptide Concentrations Predict the Risk of Cardiovascular Adverse Events from Antiinflammatory Drugs: A Pilot Trial." Clinical Chemistry 54, no. 7 (July 1, 2008): 1149–57. http://dx.doi.org/10.1373/clinchem.2007.097428.

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Abstract Background: We investigated whether higher concentrations of N-terminal pro–B-type natriuretic peptide (NT-proBNP) predicts cardiovascular adverse events (CV-AEs) in patients with osteoarthritis treated with antiinflammatory drugs. Methods: NT-proBNP was measured in baseline samples from 433 patients enrolled in a prospective randomized study designed to test the therapeutic effect of a novel metalloproteinase inhibitor. We monitored CV-AEs and retrospectively investigated their relationship to the concomitant use of selective cyclooxygenase-2 inhibitors (coxibs), traditional nonstero

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Soto-Gamez, Abel, Deng Chen, Anke G. E. Nabuurs, Wim J. Quax, Marco Demaria, and Ykelien L. Boersma. "A Bispecific Inhibitor of the EGFR/ADAM17 Axis Decreases Cell Proliferation and Migration of EGFR-Dependent Cancer Cells." Cancers 12, no. 2 (February 10, 2020): 411. http://dx.doi.org/10.3390/cancers12020411.

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Dysregulated epidermal growth factor receptor (EGFR) is an oncogenic driver of many human cancers, promoting aberrant cell proliferation, migration, and survival. Pharmacological targeting of EGFR is often challenged by acquired mechanisms of resistance. Ligand-dependent mechanisms in EGFR wild-type cells rely on ligand or receptor overexpression, allowing cells to outcompete inhibitors and perpetuate signaling in an autocrine manner. Importantly, EGFR ligands are synthesized as membrane-bound precursors that must be solubilized to enable receptor-ligand interactions. The A disintegrin and met

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Gao, Ming, Trung T. Nguyen, Mark A. Suckow, William R. Wolter, Major Gooyit, Shahriar Mobashery, and Mayland Chang. "Acceleration of diabetic wound healing using a novel protease–anti-protease combination therapy." Proceedings of the National Academy of Sciences 112, no. 49 (November 23, 2015): 15226–31. http://dx.doi.org/10.1073/pnas.1517847112.

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Nonhealing chronic wounds are major complications of diabetes resulting in >70,000 annual lower-limb amputations in the United States alone. The reasons the diabetic wound is recalcitrant to healing are not fully understood, and there are limited therapeutic agents that could accelerate or facilitate its repair. We previously identified two active forms of matrix metalloproteinases (MMPs), MMP-8 and MMP-9, in the wounds of db/db mice. We argued that the former might play a role in the body’s response to wound healing and that the latter is the pathological consequence of the disease with de

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Skuratov, A. G., A. N. Lyzikov, and V. M. Mitsura. "ASSESSMENT OF PORTAL HYPERTENSION SEVERITY IN LIVER CIRROSIS." Novosti Khirurgii 30, no. 1 (February 21, 2022): 20–27. http://dx.doi.org/10.18484/2305-0047.2022.1.20.

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Objective. Development of a non-invasive assessing diagnostic and severity grading accuracy of portal hypertension in cirrhosis of the liver. Methods. To identify diagnostically significant indicators, a statistical analysis of the data of laboratory and instrumental diagnostics was carried out in 60 patients with liver cirrhosis. The followingbiochemical indicators weredetermined: general and biochemical blood tests, coagulogram, general urine analysis; the level of interleukin-6 (IL-6), matrix metalloproteinases 1 and 9 (MMP-1, MMP-9), tissue inhibitor of matrix metalloproteinase 1 (TIMP-1),

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Mukhopadhyay, Partha, Mohanraj Rajesh, Sándor Bátkai, Yoshihiro Kashiwaya, György Haskó, Lucas Liaudet, Csaba Szabó, and Pál Pacher. "Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 5 (May 2009): H1466—H1483. http://dx.doi.org/10.1152/ajpheart.00795.2008.

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Doxorubicin (DOX) is a potent available antitumor agent; however, its clinical use is limited because of its cardiotoxicity. Cell death is a key component in DOX-induced cardiotoxicity, but its mechanisms are elusive. Here, we explore the role of superoxide, nitric oxide (NO), and peroxynitrite in DOX-induced cell death using both in vivo and in vitro models of cardiotoxicity. Western blot analysis, real-time PCR, immunohistochemistry, flow cytometry, fluorescent microscopy, and biochemical assays were used to determine the markers of apoptosis/necrosis and sources of NO and superoxide and the

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Iakovlev, A. A., A. Volkov, I. Shcherbakova, G. Tarasova, S. Malakhanov, and O. Bashtovaya. "P390 New features of molecular diagnostics of the regulation of molecular apoptotic pathway in ulcerative colitis." Journal of Crohn's and Colitis 14, Supplement_1 (January 2020): S363—S365. http://dx.doi.org/10.1093/ecco-jcc/jjz203.519.

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Abstract Background The incidence rate of ulcerative colitis (UC) in Russia is 5–30 cases per 100,000 per year. Molecular pathways of the UC development are not clear. The purpose of the work was to study the molecular interactions of the apoptotic pathway in patients with UC. Methods The clinical trial included 92 patients with UC. The clinical presentation of UC depends on the extent of involvement: distal colitis, extensive colitis; the severity of the disease. Criteria of the diagnosis of UC corresponded to ECCO Consensus. Mucosal specimens were graded according to grades 0, 1, 2, 3. The s

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BLAVIER, LAURENCE, PATRICK HENRIET, SUZAN IMREN, and YVES A. DECLERCK. "INHIBITION OF MATRIX METALLOPROTEINASES THERAPEUTIC APPLICATIONS. Tissue Inhibitors of Matrix Metalloproteinases in Cancer." Annals of the New York Academy of Sciences 878, no. 1 INHIBITION OF (June 1999): 108–19. http://dx.doi.org/10.1111/j.1749-6632.1999.tb07677.x.

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Mitkin, Nikita, Alisa Gorbacheva, Alina Ustiugova, Aksinya Uvarova, Kirill Korneev, Vsevolod Pavshintsev, and Nikita Mitkin. "713 Antibody-based approach of MT1-MMP metalloprotease inhibition results in decreased invasive properties of pancreatic cancer cells." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (November 2020): A755. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0713.

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BackgroundPancreatic cancer (PC) is one of the most aggressive types of malignant tumors due to the fact, that early stages of the disease are asymptomatic and difficult to diagnose. Matrix metalloproteinases (MMP) play a key role in progression of early PC stages through proteolysis of collagen and a range of regulators that promotes tumor invasion and angiogenesis. MMPs are considered as promising therapeutic targets, but MMP inhibitors exhibit significant efficacy exclusively in a narrow time window, that makes it difficult to use them for prevention of local relapses. That is why MMP inhib

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Gangadaran, Prakash, Ramya Lakshmi Rajendran, Ji Min Oh, Eun Jung Oh, Chae Moon Hong, Ho Yun Chung, Jaetae Lee, and Byeong-Cheol Ahn. "Identification of Angiogenic Cargo in Extracellular Vesicles Secreted from Human Adipose Tissue-Derived Stem Cells and Induction of Angiogenesis In Vitro and In Vivo." Pharmaceutics 13, no. 4 (April 5, 2021): 495. http://dx.doi.org/10.3390/pharmaceutics13040495.

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Angiogenesis is defined as the generation of new blood vessels or the sprouting of endothelial cells from a pre-existing vascular network. Angiogenesis occurs during the growth and development of an organism, the response of organs or tissues to injury, and during cancer development and progression. The majority of studies on stem-cell-derived extracellular vesicles (EVs) have used cell lines, and have primarily focused on well-known solitary proteins. Here, we isolated stem cells from human adipose tissue (ADSCs), and we isolated EVs from them (ADSC-EVs). The ADSC-EVs were characterised and 2

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Skiles, Jerry W., Nina C. Gonnella, and Arco Y. Jeng. "Inhibitors of Matrix Metalloproteinases: Design, Structure and Therapeutic Applications." Frontiers in Medicinal Chemistry - Online 1, no. 1 (January 1, 2004): 29–75. http://dx.doi.org/10.2174/1567204043396262.

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Mollace, Vincenzo, Giuseppe M. C. Rosano, Stefan D. Anker, Andrew J. S. Coats, Petar Seferovic, Rocco Mollace, Annamaria Tavernese, et al. "Pathophysiological Basis for Nutraceutical Supplementation in Heart Failure: A Comprehensive Review." Nutrients 13, no. 1 (January 17, 2021): 257. http://dx.doi.org/10.3390/nu13010257.

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There is evidence demonstrating that heart failure (HF) occurs in 1–2% of the global population and is often accompanied by comorbidities which contribute to increasing the prevalence of the disease, the rate of hospitalization and the mortality. Although recent advances in both pharmacological and non-pharmacological approaches have led to a significant improvement in clinical outcomes in patients affected by HF, residual unmet needs remain, mostly related to the occurrence of poorly defined strategies in the early stages of myocardial dysfunction. Nutritional support in patients developing H

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Michel, Piotr, Sebastian Granica, Anna Magiera, Karolina Rosińska, Małgorzata Jurek, Łukasz Poraj, and Monika Anna Olszewska. "Salicylate and Procyanidin-Rich Stem Extracts of Gaultheria procumbens L. Inhibit Pro-Inflammatory Enzymes and Suppress Pro-Inflammatory and Pro-Oxidant Functions of Human Neutrophils Ex Vivo." International Journal of Molecular Sciences 20, no. 7 (April 9, 2019): 1753. http://dx.doi.org/10.3390/ijms20071753.

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Salicylate-rich plants are an attractive alternative to synthetic anti-inflammatory drugs due to a better safety profile and the advantage of complementary anti-inflammatory and antioxidant effects of the co-occurring non-salicylate phytochemicals. Here, the phytochemical value and biological effects in vitro and ex vivo of the stems of one of such plants, Gaultheria procumbens L., were evaluated. The best extrahent for effective recovery of the active stem molecules was established in comparative studies of five extracts. The UHPLC-PDA-ESI-MS3, HPLC-PDA, and UV-photometric assays revealed tha

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Uhl, Franziska E., Sarah Vierkotten, Darcy E. Wagner, Gerald Burgstaller, Rita Costa, Ina Koch, Michael Lindner, Silke Meiners, Oliver Eickelberg, and Melanie Königshoff. "Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures." European Respiratory Journal 46, no. 4 (April 30, 2015): 1150–66. http://dx.doi.org/10.1183/09031936.00183214.

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Chronic obstructive pulmonary disease (COPD) is characterised by a progressive loss of lung tissue. Inducing repair processes within the adult diseased lung is of major interest and Wnt/β-catenin signalling represents a promising target for lung repair. However, the translation of novel therapeutic targets from model systems into clinical use remains a major challenge.We generated murine and patient-derived three-dimensional (3D) ex vivo lung tissue cultures (LTCs), which closely mimic the 3D lung microenvironment in vivo. Using two well-known glycogen synthase kinase-3β inhibitors, lithium ch

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Pasternak, Björn, and Per Aspenberg. "Metalloproteinases and their inhibitors—diagnostic and therapeutic opportunities in orthopedics." Acta Orthopaedica 80, no. 6 (December 2009): 693–703. http://dx.doi.org/10.3109/17453670903448257.

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Napoli, Salvatore, Chiara Scuderi, Giuseppe Gattuso, Virginia Di Bella, Saverio Candido, Maria Sofia Basile, Massimo Libra, and Luca Falzone. "Functional Roles of Matrix Metalloproteinases and Their Inhibitors in Melanoma." Cells 9, no. 5 (May 7, 2020): 1151. http://dx.doi.org/10.3390/cells9051151.

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The extracellular matrix (ECM) plays an important role in the regulation of the tissue microenvironment and in the maintenance of cellular homeostasis. Several proteins with a proteolytic activity toward several ECM components are involved in the regulation and remodeling of the ECM. Among these, Matrix Metalloproteinases (MMPs) are a class of peptidase able to remodel the ECM by favoring the tumor invasive processes. Of these peptidases, MMP-9 is the most involved in the development of cancer, including that of melanoma. Dysregulations of the MAPKs and PI3K/Akt signaling pathways can lead to

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Zask, Arie, Jeremy I. Levin, Loran M. Killar, and Jerauld S. Skotnicki. "Inhibition of Matrix Metalloproteinases: Structure Based Design." Current Pharmaceutical Design 2, no. 6 (December 1996): 624–61. http://dx.doi.org/10.2174/1381612802666221004190555.

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Matrix metalloproteinases (MMP) have been implicated in a variety of diseases in which the destruction of connective tissue is an important pathological event. These include osteo and rheumatoid arthritis, tumor metastasis and angiogenesis, and corneal ulceration. As a result, there has been a great deal of activity directed towards the design of MMP inhibitors as therapeutic agents for the treatment of these conditions. Progress in the field has now evolved to a degree where potent, low molecular weight, orally active inhibitors have been discovered and advanced to clinical trials. While a ma

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Liva, Francesca, Doretta Cuffaro, Elisa Nuti, Susanna Nencetti, Elisabetta Orlandini, Giovanni Vozzi, and Armando Rossello. "Age-related Macular Degeneration: Current Knowledge of Zinc Metalloproteinases Involvement." Current Drug Targets 20, no. 9 (June 11, 2019): 903–18. http://dx.doi.org/10.2174/1389450120666190122114857.

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Background: Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly with limited therapeutic options. The disease is characterized by photoreceptor loss in the macula and reduced Retinal Pigment Epithelium (RPE) function, associated with matrix degradation, cell proliferation, neovascularization and inflammation. Matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) play a critical role in the physiology of extracellular matrix (ECM) turnover and, in tu

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Młynarczyk, G., J. Kudelski, B. Darewicz, Z. Galewska, and L. Romanowicz. "Matrix metalloproteinases in urinary system tumours. Part I - Matrix metalloproteinases in renal cell carcinoma." Progress in Health Sciences 7, no. 1 (March 3, 2017): 0. http://dx.doi.org/10.5604/01.3001.0010.1878.

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Extracellular matrix metalloproteinases - MMPs, also referred to as matrixines, provide a group of proteolytic enzymes. They belong to the family of endopeptidases that break down elements of extracellular matrix, resulting in its continuous remodelling. Their activity is regulated at multiple levels, while tissue inhibitors of metalloproteinases play a major role in this process. Metalloproteinases play a significant part in neoplastic processes due to their contribution to local tumour invasion and formation of distant metastases, as well as to angiogenesis Urinary tract tumours pose a signi

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Goetzl, E. J., M. J. Banda, and D. Leppert. "Matrix metalloproteinases in immunity." Journal of Immunology 156, no. 1 (January 1, 1996): 1–4. http://dx.doi.org/10.4049/jimmunol.156.1.1.

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Abstract Matrix metalloproteinases (MMPs) are a family of zinc-containing endo-proteinases that share structural domains but differ in substrate specificity, cellular sources, and inducibility. Macrophage production and secretion of large quantities of many MMPs, after contact with matrix proteins, is enhanced by surface determinants on activated T cells and suppressed by cytokines from Th1 and Th2 cells. T cells secrete predominantly the gelatinases MMP-2 and -9, after beta 1, integrin- or vascular cell adhesion molecule (VCAM)-1-dependent stimulation by cytokines and inflammatory mediators.

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Chaussain-Miller, C., F. Fioretti, M. Goldberg, and S. Menashi. "The Role of Matrix Metalloproteinases (MMPs) in Human Caries." Journal of Dental Research 85, no. 1 (January 2006): 22–32. http://dx.doi.org/10.1177/154405910608500104.

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The objective of this review is to summarize our understanding of the role of host matrix metalloproteinases (MMPs) in the caries process and to discuss new therapeutic avenues. MMPs hydrolyze components of the extracellular matrix and play a central role in many biological and pathological processes. MMPs have been suggested to play an important role in the destruction of dentin organic matrix following demineralization by bacterial acids and, therefore, in the control or progression of carious decay. Host-derived MMPs can originate both from saliva and from dentin. They may be activated by a

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Młynarczyk, G., J. Kudelski, B. Darewicz, Z. Galewska, and L. Romanowicz. "Matrix metalloproteinases in urinary system tumors. Part II - Matrix metalloproteinases in urinary bladder carcinoma." Progress in Health Sciences 7, no. 1 (March 8, 2017): 0. http://dx.doi.org/10.5604/01.3001.0010.1879.

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Matrix metalloproteinases (MMPs), also referred to as matrixines, provide a group of proteolytic enzymes. They belong to the family of endopeptidases that break down elements of the extracellular matrix, resulting in its continuous remodeling. Their activity is regulated at multiple levels, while tissue inhibitors of metalloproteinases play a major role in this process. Metalloproteinases play a significant part in neoplastic processes due to their contribution to local tumor invasion, the formation of distant metastases, as well as to angiogenesis Urinary tract tumors pose a significant diagn

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Smeglin, Anthony, and William H. Frishman. "Elastinolytic Matrix Metalloproteinases and Their Inhibitors as Therapeutic Targets in Atherosclerotic Plaque Instability." Cardiology in Review 12, no. 3 (May 2004): 141–50. http://dx.doi.org/10.1097/01.crd.0000105000.46909.81.

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Obermüller, Nicholas, Natividad Morente, Bettina Kränzlin, Norbert Gretz, and Ralph Witzgall. "A possible role for metalloproteinases in renal cyst development." American Journal of Physiology-Renal Physiology 280, no. 3 (March 1, 2001): F540—F550. http://dx.doi.org/10.1152/ajprenal.2001.280.3.f540.

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The expansion of cysts in polycystic kidneys bears several similarities to the invasion of the extracellular matrix by benign tumors. We therefore hypothesized that cyst-lining epithelial cells produce extracellular matrix-degrading metalloproteinases and that the inhibition of these enzymes may represent a potential target for therapeutic intervention. Using in situ hybridization, we first analyzed the expression of membrane-type metalloproteinase 1 (MMP-14), an essential matrix metalloproteinase, of its inhibitor TIMP-2, and of the cytokine transforming growth factor (TGF)-β2 in the ( cy/ +)

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