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Rozprawy doktorskie na temat „Metastatic carcinoma”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Nordman, Ina IC Clinical School St Vincent's Hospital Faculty of Medicine UNSW. "Surrogate endpoints of survival in metastatic carcinoma." Publisher:University of New South Wales. Clinical School - St Vincent's Hospital, 2008. http://handle.unsw.edu.au/1959.4/42791.

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In most randomised controlled trials (RCTs), a large number of patients need to be followed over many years, for the clinical benefit of the drug to be accurately quantified (1). Using an early proxy, or a surrogate endpoint, in place of the direct endpoint of overall survival (OS) could theoretically shorten the duration of RCTs and minimise the exposure of patients to ineffective or toxic treatments (2, 3). This thesis examined the relationship between surrogate endpoints and OS in metastatic colorectal cancer (CRC), advanced non-small cell lung cancer (NSCLC) and metastatic breast cancer (M

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Lee, Yee-ki Carol. "Effect of dietary fatty acids on metastatic hepatocellular carcinoma /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39707349.

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Malek, Joël. "Genetic alterations of the metastatic lesions in ovarian carcinoma." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T109.

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Le cancer de l’ovaire est le cancer gynécologique avec la plus grande mortalité due à un diagnostique tardif au stade de maladie extensive péritonéale. Malgré les progrès de la chirurgie radicale et de la chimiothérapie les récurrences abdominales demeurent la cause la plus fréquente de mortalité. Il existe peu d’études de la maladie métastatique péritonéale. Notre hypothèse de travail est que les différences entre la maladie métastatique et la tumeur primaire sont primordiales dans la survenue d’une maladie résiduelle ou récurrente. Nous avons utilisé une approche exhaustive comprenant des ét

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Uva, V. "FOXP3 EXPRESSION IN BREAST CARCINOMA CELLS AND METASTATIC SPREAD." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229557.

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Forkhead box P3 (FOXP3), a gene member of the forkhead/winged-helix family of transcription regulators, is implicated in regulating immune system development and function. This gene has been found to be of crucial importance for the generation of CD4+CD25+ regulatory T cells (Tregs). Tregs express both the full-length FOXP3 and Δ2FOXP3 natural splice variant. In addition to its expression in the lymphocyte lineage, studies have recently described FOXP3 expression in non-hematopoietic-derived cells, including cancerous or normal epithelial cells of multiple lineages and origins. The role of FO

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Bartrolí, Comellas Mariona. "Prognostic markers and therapeutic targets for metastatic renal cell carcinoma." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/664198.

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Targeting cancer metastasis has gained considerable importance in the recent years when aiming to increase patients’ overall survival. In Renal Cell Carcinoma (RCC), the discovery of metastatic biomarkers and targets is still required, as most patients present metastatic disease at the time of diagnosis. Therefore, the aim of this thesis is the discovery of new biomarkers and targets of metastatic RCC using two variants of a patient-derived orthoxenograft (PDOX) animal model of clear cell RCC (ccRCC). Indeed, PDOX models have recently gained significant relevance for studying the progressio

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6

Pilborough, Alice Elizabeth. "Tumour-stromal crosstalk in metastatic lymph nodes of oral squamous cell carcinoma." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/22053/.

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Kerr, Ian Balfour. "A study of metastasis in colorectal carcinoma using DNA recombinant and molecular hybridisation techniques." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/19010.

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Ho, Chi-lai, and 何志禮. "Dual-tracer positron emission tomography in the evaluation ofprimary & metastatic hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45205024.

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Griffin, Ryan D. "MULTISPECTRAL CO-OCCURRENCE ANALYSIS FOR AUTOMATED TUMOR DETECTION IN METASTATIC MEDULLARY THYROID CARCINOMA." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1285101309.

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Okuno, Tomoko. "Loss of heterozygosity on 10q23 is involved in metastatic recurrence of hepatocellular carcinoma." Kyoto University, 2011. http://hdl.handle.net/2433/142555.

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MARCAZZAN, SABRINA. "DEVELOPMENT OF MOUSE MODELS OF ORAL SQUAMOUS CELL CARCINOMA (OSCC) METASTASIS FOR THE EVALUATION OF EMERGING ANTI-METASTATIC NANOMEDICINE DRUGS." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/603863.

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Oral Squamous Cell Carcinoma (OSCC) is included in the Head and Neck Squamous Cell Carcinoma (HNSCC) group, which is the sixth most common cancer diagnosed worldwide. While the locoregional control has been increased thanks to the combination therapy, the incidence of distant metastasis is increasing. Nanomedicine therapies have been clinically approved for the treatment of several types of cancers and were used in few clinical trials on HNSCC patients. However, the efficacy of nanomedicine therapies was limited, especially for the treatment of metastatic OSCC. In the preclinical setting, more

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12

Swofford, Brenen P., and Tomislav Dragovich. "Durable and Complete Response to Herceptin Monotherapy in Patients with Metastatic Gastroesophageal Cancer." KARGER, 2017. http://hdl.handle.net/10150/626424.

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Gastroesophageal cancer is the sixth leading cause of cancer-related death worldwide. The 2 most common histologies are squamous cell carcinoma and adenocarcinoma, which has seen an increase in incidence correlating with an increase in obesity in developed countries. Gastroesophageal adenocarcinoma has a preponderance to metastasize early, making it a highly lethal cancer with a low 5-year survival rate of similar to 15-25%. Therefore, for the majority of patients, treatment focuses on palliation and prolongation of survival. Combination chemotherapy regimens, mostly platinum-based, have only

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13

Forsyth, Leigh James. "Identification of DNA sequences involved in the metastatic phenotype of human prostatic carcinoma cells." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269601.

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14

Dhanda, Jagtar. "Molecular indicators and tumour models of extracapsular spread in metastatic oral squamous cell carcinoma." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/19295/.

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Introduction Extracapsular spread (ECS) is the single most adverse prognosticator for recurrence and death in metastatic oral squamous cell carcinoma (OSCC) and relapse is common in both primary and metastatic sites. It is rarely exploited for biological investigation with limited study of its molecular determinants and the absence of a tumour model. The absence of a biomarker also means exhaustive histological examination after surgery is required for diagnosis. ECS is a late manifestation of the metastatic cascade and would be expected to be intimately related to interactions between tumour

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15

Kelly, Stephen Richard. "The expression of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in metastatic colorectal carcinoma (CRC)." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412204.

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16

Yau, Wing-lung, and 邱泳龍. "Identification of miR-106b over-expression in metastatic hepatocellular carcinoma by using the orthotopic animal model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45204032.

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17

Land, Walker, Dan Margolis, Ronald Gottlieb, Elizabeth Krupinski, and Jack Yang. "Improving CT prediction of treatment response in patients with metastatic colorectal carcinoma using statistical learning theory." BioMed Central, 2010. http://hdl.handle.net/10150/610011.

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BACKGROUND:Significant interest exists in establishing radiologic imaging as a valid biomarker for assessing the response of cancer to a variety of treatments. To address this problem, we have chosen to study patients with metastatic colorectal carcinoma to learn whether statistical learning theory can improve the performance of radiologists using CT in predicting patient treatment response to therapy compared with the more traditional RECIST (Response Evaluation Criteria in Solid Tumors) standard.RESULTS:Predictions of survival after 8 months in 38 patients with metastatic colorectal carcinom

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18

Pierobon, Elisa Sefora/ES. "TRATTAMENTO ABLATIVO CON MICROONDE DI METASTASI EPATICHE DA TUMORE DELLA MAMMELLA: STUDIO DI FATTIBILITÀ ED EFFICACIA." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3426792.

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INTRODUCTION Prognosis of patients with breast cancer liver metastases is still dismal. Some retrospective data support adjuvant surgery in selected patients. Ablative treatment in the management of breast cancer liver metastases remains controversial. MATERIAL AND METHODS We evaluated the efficacy (complete ablation and recurrence rate) and the safety (morbidity and mortality) of the microwave ablation treatment (MWA) of breast cancer liver metastases, performed in our Center from 2009 to 2016. Analysis was performed on a nodule-oriented and patient-oriented base. RESULTS Median t

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19

Minata, Mutsuko. "Postoperative detection of α-fetoprotein mRNA in blood as a predictor for metastatic recurrence of hepatocellular carcinoma". Kyoto University, 2002. http://hdl.handle.net/2433/149325.

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Sharma, Purva, James Kim, Devapiran Jaishankar, and Sakshi Singal. "EXTENDED PROGRESSION-FREE SURVIVAL ON FIRST LINE TREATMENT WITH DOCETAXEL IN PATIENT WITH METASTATIC TRIPLE NEGATIVE BREAST CARCINOMA." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/43.

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Docetaxel is a chemotherapeutic agent in the taxane group of drugs which is commonly used in the first line setting for metastatic hormone receptor negative breast cancer. We present a case of a 46 year old female who was diagnosed with de novo triple negative metastatic breast carcinoma, and has had an extended progression free survival (PFS) of almost 5 years on first line single agent treatment with Docetaxel. 46 year old female presented with a large left breast mass as well as axillary mass which revealed grade 3 invasive ductal carcinoma of breast on biopsy of both sites. Tumor was estro

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21

Xu, Wei. "Cytogenetic analysis of a murine mammary carcinoma in vitro and during progression from primary to metastatic growth in vivo." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq20717.pdf.

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Shestowsky, William S. "Production and characterization of a monoclonal antibody to a highly metastatic and organ-selective variant of the Lewis lung carcinoma." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61747.

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Vinayan, Anup. "Targeted anti-angiogenic therapy in metastatic renal cell carcinoma and methodological improvements in assessment of therapeutic response with imaging biomarkers." Thesis, University of Hertfordshire, 2018. http://hdl.handle.net/2299/20960.

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Background: Drugs targeting angiogenic pathway remain the mainstay of treatment for metastatic renal cell carcinoma (mRCC). Tyrosine Kinase Inhibitors (TKI) as Sunitinib, Pazopanib as single agents and humanised monoclonal antibody bevacizumab (Bev) in combination with Interferon- α2a (IFN) have established as the first-line therapy for mRCC. Despite improvements in treatment, there are multiple questions which remain unanswered. In the combination of Bev and IFN, the respective role of each drug and whether any additional anti-angiogenic activity is gained by adding IFN to Bev remains unknown

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Kale, Hrishikesh P. "Economic Burden of Renal Cell Carcinoma (RCC) and Treatment Patterns, Overall Survival and Healthcare Costs among Older Metastatic RCC Patients." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5555.

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Background Renal cell carcinoma (RCC) is the most common type of kidney cancer. Patients diagnosed with metastatic RCC (mRCC) have shorter overall survival compared to those diagnosed at earlier stages. Several targeted therapies, which cost from $7,000 - $16,000 per month have been approved since 2005 to treat mRCC. In addition, there is a growing interest in the use of cytoreductive nephrectomy (CN) with targeted therapies among mRCC patients. However, little is known regarding the economic burden of RCC and role of CN and prescribing patterns of targeted therapies among older mRCC patients.

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CIMADAMORE, ALESSIA. "Biomarkers of angiogenesis and clinical outcomes to Cabozantinib and Everolimus in Patients with Metastatic Renal Cell Carcinoma from the Randomized Phase III METEOR Trial." Doctoral thesis, Università Politecnica delle Marche, 2022. https://hdl.handle.net/11566/295826.

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Gli inibitori del recettore anti-angiogenico VEGF (VEGFR) sono stati approvati per il trattamento di pazienti con carcinoma renale (RCC) metastatico e la loro efficacia è maggiore nei tumori con elevata angiogenesi. Dato che Cabozantinib inibisce multipli recettori tirosin-chinasici, incluso VEGFR, l'obiettivo dello studio è quello di valutare se marcatori di angiogenesi, ovvero la densità microvascolare (MVD) e la densità dei mastociti (MCD), sono predittivi di risposta alla terapia con cabozantinib versus everolimus. Sono stati utilizzati campioni istologici di carcinomi renali di pazienti a

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26

Wu, Rita Shiu-fung. "Effects of B7.1, IFN-gamma, and antisense TGF-beta gene transfer on the tumorigenicity of murine 4T1 metastatic mammary carcinoma cells." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/280475.

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Cancer progression is attributed in part to immune evasion strategies that include lack of co-stimulation, down-regulation of cell surface MHC molecules, and secretion of immunosuppressive factors such as transforming growth factor-β (TGF-β). Gene therapy has been employed to counter these mechanisms of immune evasion by transference of B7.1, IFN-γ or antisense TGF-β genes into tumor cells resulting in cell surface expression of B7.1, upregulation of MHC class I and class II molecules, or elimination tumor-derived TGF-β, respectively. Although each of these transgenes has been shown to alter t

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Hall, Charles. "Ex vivo reprogramming of tumor-reactive immune cells from FVBN202 mice bearing lung metastatic mammary carcinoma: an immunotherapeutic opportunity revealed against recurrence." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3176.

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Metastatic breast cancer treatment has seen few advances in recent years, yet treatment resistance continues to rise, causing disease recurrence. A pilot study was performed to determine the efficacy of ex vivo expansion and reprogramming of tumor-reactive immune cells from experimental metastatic tumor-sensitized mice. Also, phenotypic changes in tumors due to metastasis or tumor microenvironment influences were characterized. Metastatic neu+ mouse mammary carcinoma (mMMC) and its distant relapsing neu-antigen-negative variant (mANV) were investigated in FVBN202 mice. Tumor-reactive central m

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Duffie, Gordon Patrick. "Tumoricidal activity of pulmonary alveolar macrophages isolated from C57BL/6 mice bearing either a cloned metastatic or nonmetastatic variant of Lewis lung carcinoma." Virtual Press, 1988. http://liblink.bsu.edu/uhtbin/catkey/558376.

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The spontaneous tumoricidal ability of pulmonary alveolar macrophages (PAM) isolated from C57B1/6 mice bearing either a metastatic or a nonmetastatic cloned variant of Lewis lung carcinoma (LLC) was examined in vitro. During the early weeks of tumor development the cytotoxicity mediated by macrophages was enhanced in the tumor-bearing mice, especially in the metastatic tumor bearers. Later in tumor progress (week 4) the spontaneous cytotoxicity of both groups typically declined to levels less than those of normal macrophages. Experiments were performed to determine if macrophages could be acti

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Raposo-Ferreira, Talita Mariana Morata [UNESP]. "Estudo em larga escala da expressão gênica de carcinomas mamários em cadelas." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/143484.

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Submitted by Talita Mariana Morata Raposo null (talita_raposo@yahoo.com.br) on 2016-08-26T23:53:52Z No. of bitstreams: 1 tese.pdf: 7349096 bytes, checksum: 15c4a9aa3753843c66b8604dad27c6e8 (MD5)<br>Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-08-30T18:12:04Z (GMT) No. of bitstreams: 1 ferreira_tmmr_dr_jabo.pdf: 7349096 bytes, checksum: 15c4a9aa3753843c66b8604dad27c6e8 (MD5)<br>Made available in DSpace on 2016-08-30T18:12:04Z (GMT). No. of bitstreams: 1 ferreira_tmmr_dr_jabo.pdf: 7349096 bytes, checksum: 15c4a9aa3753843c66b8604dad27c6e8 (MD5)

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Gagno, Sara. "Innovative strategies for tailoring therapy in cancer patient: pharmacogenetics and hormone therapy personalization in metastatic or locally advanced breast cancer patients treated with Exemestane." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3423964.

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Background: Response to chemotherapeutic agents is highly variable among patients both in terms of efficacy and tolerability; consequently personalization of drug therapy is one of the main objective in cancer treatment in order to reduce adverse drug reactions (ADRs), improve efficacy while decreasing the costs of treatments. Many factors account for inter-individual differences. Among them, patient’s genetic background has attracted interest for personalization of drug therapy (Pharmacogenetics). Breast cancer (BC) is the female most frequently diagnosed malignancy and the primary cause of

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Miller, Kurt, Rudolf Morant, Arnulf Stenzl, Manfred P. Wirth, and Ivan Zuna. "A Phase II Study of the Central European Society of Anticancer-Drug Research (CESAR) Group: Results of an Open-Label Study of Gemcitabine plus Cisplatin with or without Concomitant or Sequential Gefitinib in Patients with Advanced or Metastatic Transitional Cell Carcinoma of the Urothelium." Karger, 2016. https://tud.qucosa.de/id/qucosa%3A70589.

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Introduction: This phase II trial evaluated the efficacy and safety of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, gefitinib, in combination with first-line chemotherapy in advanced urothelial cancer. Methods: Chemotherapy-naïve patients with advanced or metastatic urothelial carcinoma were randomized 1:1:1 to receive six cycles of chemotherapy (gemcitabine 1,250 mg/m 2 on days 1 and 8, and cisplatin 70 mg/m 2 on day 1 of every cycle) concomitantly with gefitinib 250 mg/day (arm A); or with sequential gefitinib (arm B); or alone (arm C). The primary endpoint was the

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Pretscher, Dominik. "Distribution of immune cells in head and neck cancer : CD8+ T-cells and CD20+ B-cells in metastatic lymph nodes are associated with favourable outcome in patients with oro- and hypopharyngeal carcinoma." kostenfrei, 2010. http://d-nb.info/1000329054/34.

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Ostheimer, Christian Emil Arthur Verfasser], Dirk [Akademischer Betreuer] Vordermark, Bernd [Akademischer Betreuer] Schmidt, and Daniel [Akademischer Betreuer] [Zips. "Prognostic and predictive significance of osteopontin and other hypoxia-related plasma proteins in the radiotherapy of locally advanced and metastatic bronchial carcinoma / Christian Emil Arthur Ostheimer. Betreuer: Dirk Vordermark ; Bernd Schmidt ; Daniel Zips." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2015. http://d-nb.info/1089085419/34.

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Kwok, Mon-sze. "Study of metastatic suppressing genes on ovarian carcinomas /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36586328.

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Kwok, Mon-sze, and 郭夢思. "Study of metastatic suppressing genes on ovarian carcinomas." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45010729.

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LeBedis, Christina. "Lymph node involvement in breast carcinoma metastasis." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31255.

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Since lymph node stromal cells remain largely uncharacterized with respect to cell surface markers and function, their role in regulating the growth and invasion of disseminated cancer cells, including breast carcinoma has, to date, been virtually unexplored. In the present study, we asked whether peripheral lymph node cells could modulate the growth of breast carcinoma cells and, thereby, contribute to the progression of the metastatic process. Primary cultures of rat peripheral lymph node stromal cells were obtained by limiting dilution and two sublines, STA4 and STB12, with breast carcinoma

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吳曉靑 and Xiaoqing Wu. "Post-radiotherapy cervical metastasis in nasopharyngeal carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31222018.

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Wu, Xiaoqing. "Post-radiotherapy cervical metastasis in nasopharyngeal carcinoma /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20843252.

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Silva, Maria João da Costa Soares da. "Clinical and molecular characterization of feline mammary carcinomas overexpressing HER2 proto-oncogene (FMC-HER2+) : new strategies for effective diagnostic and cancer therapy." Doctoral thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2016. http://hdl.handle.net/10400.5/12008.

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Tese de Doutoramento em Ciências Veterinárias na Especialidade de Ciências Biológicas e Biomédicas<br>mariajosoares@gmail.com<br>Considering the scarce data available in feline mammary carcinoma (FMC) and despite its importance in veterinary clinical practice, this thesis emerges in order to increase the knowledge of this tumor type, especially the FMC-HER2 positive. In the first two studies, the protocols for detection and quantification of the fHER2 and Ki-67 biomarkers were optimized and validated. These studies demonstrated that, in cats, the incidence of fHER2 overexpression were similar

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Clark, Richard R. "Lymph node metastasis in auricular squamous cell carcinoma." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/547/.

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Introduction Squamous cell carcinoma of the auricle has an unusually high rate of lymph node metastases when compared to similar tumours at other sites. The lymph nodes affected are close to the base of the skull and in the neck. Development of metastasis carries a poor prognosis and most patients will subsequently die of failure of loco-regional control. Despite the likelihood of a poor outcome nothing can be done for patients prior to development of metastasis, as the risk of spread is not sufficiently high to warrant intervention in all patients. They are therefore treated with a ‘wait and

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BIANCONI, MARISTELLA. "Il profilo angiogenico nel carcinoma renale metastatico: implicazioni prognostiche e terapeutiche." Doctoral thesis, Università Politecnica delle Marche, 2018. http://hdl.handle.net/11566/253118.

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Il trattamento del carcinoma renale avanzato è radicalmente cambiato nell’ultimo decennio. Le opzioni disponibili sono per la maggior parte dirette contro la via dell’angiogenesi. Nonostante questo i pazienti trattati sperimentano outcome molto diversi tra di loro e, al momento, non possediamo fattori predittivi. Sulla scorta delle nostre precedenti analisi dei polimorfismi di VEGF e VEGFR nel carcinoma renale avanzato in pazienti trattati in prima linea con sunitinib o pazopanib, abbiamo voluto analizzare l’eventuale influenza di tali polimorfismi per quanto concerne la seconda linea. Dei p

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Yuen, Po-wing. "The study of nodal metastasis of oral tongue carcinoma." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39793837.

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Ip, Ying-chi. "MT1-MMP in relation to metastasis of hepatocellular carcinoma." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31490189.

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Haq, Mahmudul. "Host-tumor interactions in skeletal metastasis of prostate carcinoma." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56996.

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Approximately 70% of patients with prostatic cancer develop bone metastases. Metastatic prostate adenocarcinomas are associated with high mortality rates and represent a leading cause of cancer-related deaths among males. To study the host-tumor interactions underlying the predilection of prostate cancer cells for skeletal bone, an experimental model was developed using rat Dunning carcinoma Mat-LyLu cells. Inoculations of these cells into the left ventricle of the heart led to the development of spinal metastases in 100% of inoculated animals. A subline of Mat-LyLu (Mat-LyLu-B5) was subsequen

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韋霖 and William I. Wei. "Surgery for post-radiotherapy cervical metastasis in nasopharyngeal carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1991. http://hub.hku.hk/bib/B31979543.

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Ip, Ying-chi, and 葉瑩芝. "MT1-MMP in relation to metastasis of hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31490189.

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Yuen, Po-wing, and 袁寶榮. "The study of nodal metastasis of oral tongue carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39793837.

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Volk, Andreas, Stephan Kersting, Ralf Konopke, et al. "Surgical Therapy of Intrapancreatic Metastasis from Renal Cell Carcinoma." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136489.

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Background: Pancreatic métastases from renal cell carcinoma (RCC) are clinically rare but highly resectable. The aim of this article is to identify patients who profit from pancreatic resection of RCC despite the invasiveness of the surgery. Methods: Between January 1996 and December 2007, data from 744 patients were collected in a prospective pancreatic surgery database, and patients with metastasis into the pancreas from RCC were identified. Results: Resective surgery was performed in 14 patients with metastasis to the pancreas from RCC. Most patients were clinically asymptomatic. The median

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Volk, Andreas, Stephan Kersting, Ralf Konopke, et al. "Surgical Therapy of Intrapancreatic Metastasis from Renal Cell Carcinoma." Karger, 2009. https://tud.qucosa.de/id/qucosa%3A27708.

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Background: Pancreatic métastases from renal cell carcinoma (RCC) are clinically rare but highly resectable. The aim of this article is to identify patients who profit from pancreatic resection of RCC despite the invasiveness of the surgery. Methods: Between January 1996 and December 2007, data from 744 patients were collected in a prospective pancreatic surgery database, and patients with metastasis into the pancreas from RCC were identified. Results: Resective surgery was performed in 14 patients with metastasis to the pancreas from RCC. Most patients were clinically asymptomatic. The median

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GIACOBBE, ARIANNA. "Two novel p63 transcriptional target genes regulating cell metabolism and metastasis." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2014. http://hdl.handle.net/2108/204221.

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La famiglia di p53, costituita dai tre fattori di trascrizione p53, p63 e p73, assume un ruolo chiave nel direzionare il destino di una cellula verso la sopravvivenza o attivando meccanismi di morte cellulare programmata. Sebbene la loro struttura genica sia simile, p63 e p73 codificano per varie isoforme generate a partire da promotori diversi all’estremità 5’ e da meccanismi di splicing alternativo al 3’, a seguito del quale derivano isoforme TA complete del dominio di trans-attivazione all’N-terminale o isoforme tronche denominate ΔN. Il capostipite della famiglia, p53, è principalmente des

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