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Rozprawy doktorskie na temat „Metastatic Head”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Paccione, Rachel J. "Vimentin Overexpression Contributes To the Biological Properties of Metastatic Head and Neck Cancer Cells." VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd/1084.

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Epithelial to mesenchymal transition occurs in the later stages of epithelial tumor progression, with cells expressing mesenchymal markers. Of these, the intermediate filament protein vimentin is frequently upregulated in metastatic carcinomas. Previously, microarray studies showed that the gene encoding vimentin is highly upregulated in metastatic HN12 cells compared to a related primary tumor cell line. In this study, we confirmed this difference using real-time quantitative PCR, western blot analysis, and immunostaining. Furthermore, EGF and TGF-β, growth factors that induce migration and i

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Stahle, Jessica Anne. "Diffusion Weighted MR Imaging in the Differentiation between Metastatic and Benign Lymph Nodes in Canine Patients with Head and Neck Disease." Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/86612.

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In dogs with large primary tumors, regional lymph node involvement or evidence of distant metastasis can have worse prognoses and significantly decreased survival. Lymph node size alone has been shown to be insufficient as a predictor for the accurate clinical staging of some canine neoplasia, including oral malignant melanoma. However, regional lymph nodes of the oral cavity, such as the medial retropharyngeal lymph nodes, are difficult to access for routine sampling. Diffusion weighted magnetic resonance imaging (DWI) has demonstrated the ability to differentiate metastatic from inflammator

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Pretscher, Dominik. "Distribution of immune cells in head and neck cancer : CD8+ T-cells and CD20+ B-cells in metastatic lymph nodes are associated with favourable outcome in patients with oro- and hypopharyngeal carcinoma." kostenfrei, 2010. http://d-nb.info/1000329054/34.

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Benaich, Nathan. "MicroRNA modulators of head and neck cancer metastasis." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648432.

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Homer, Jarrod James. "Studies on angiogenesis in head and neck squamous cell carcinoma." Thesis, University of Hull, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342866.

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6

周穎嫻 and Wing-han Vivian Chow. "Genes associated with invasion and metastasis of head and neck cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31222468.

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Chow, Wing-han Vivian. "Genes associated with invasion and metastasis of head and neck cancer /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22142526.

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Mooney, Craig Paul. "Cutaneous Squamous Cell Carcinoma of the Head and Neck Identifying Metastasis and High-Risk Characteristics." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/24946.

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Introduction: Head and Neck cutaneous Squamous Cell Carcinoma (HNcSCC) is one of the most common cancers in the world and is particularly prevalent in Australia. Regional metastasis remains one of the most important determinants of survival but predicting which lesions metastasise remains a challenge. Current staging systems have been shown to poorly stratify patient survival. Methodology: Three studies were initiated: (1) A prospective trial of patients with high risk primary HNcSCC underwent sentinel node biopsy (SNB) to identify subclinical metastasis. Patients were followed to determine t

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9

Moya, Plana Antoine. "Recherche de biomarqueurs pronostiques dans le mélanome muqueux non opérable et/ou métastatique : Régulation traductionnelle de SOX10 par l’hexokinase 2 et modulation de l'agressivité tumorale dans le mélanome cutané Prognostic Value and Therapeutic Implications of Nodal Involvement in Head and Neck Mucosal Melanoma Evaluation of the Efficacy of Immunotherapy for Non-Resectable Mucosal Melanoma Oncologic Outcomes, Prognostic Factor Analysis and Therapeutic Algorithm Evaluation of Head and Neck Mucosal Melanomas in France Mélanomes cutanés cervico-faciaux Prognostic 18F-FDG PET Biomarkers in Metastatic Mucosal and Cutaneous Melanoma Treated with Immune Checkpoint Inhibitors Targeting PD-1 and CTLA-4." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS069.

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Les mélanomes muqueux sont rares avec un potentiel métastatique important. L’immunothérapie est un traitement prometteur dans ce sous-type agressif de mélanome. L’analyse de biomarqueurs de réponse à une immunothérapie anti-PD1 chez 23 patients présentant un mélanome muqueux non opérable et/ou métastatique a montré que l’activation du complexe d’initiation de la traduction, eIF4F, était fortement prédictive de cette réponse. Cette activation a été mesurée par un test de proximité entre les sous-unités eIF4E et eIF4G. Les autres marqueurs admis, tels que l’expression tumorale de PD-L1 ou les ca

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10

Luangdilok, Sutima. "An Investigation of Signalling Pathways linked to Lymphatic Metastasis in Squamous Cell Carcinomas of the Head and Neck." Thesis, Institute of Cancer Research (University Of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487311.

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Squamous cell carcinomas of the head and neck (SCCHN) spread predominantly by local invasion and lymphatic dissemination. The aim of this project was to learn more about the molecular mechanisms of lymphatic metastasis in this disease. EGFR is a major driver of progression, invasion and metastasis in SCCHN. Ip. addition, signalling via chemokine receptors such as CXCR4 and CCR7 and the lymphangiogenic cytokine receptor VEGFR-3 has been implicated in lymphatic metastasis. My first aim was to measure expression levels in SCCHN cell lines, determine their interactions with EGFR and the signalling

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11

O'Hagan, Kyle Leonard. "A role for heat shock protein 90 (Hsp90) in fibronectin matrix dynamics." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1018260.

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To date, a significant portion of research has been devoted to understanding the biological role of the molecular chaperone, heat shock protein 90 (Hsp90), in cancer development and metastasis. Studies have alluded to over 300 clients for intracellular Hsp90, many of which are involved in oncogenic signaling pathways, making Hsp90 a bone fide drug target with several inhibitors already in clinical trials. In recent years, a limited number of extracellular Hsp90 clients have been elucidated with roles in cancer cell migration and invasion. Examples of such clients include matrix metalloproteina

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12

Ruokolainen, H. (Henni). "The prognostic role of matrix metalloproteinase -2 and -9 (MMP-2, MMP-9) and their tissue inhibitors -1 and -2 (TIMP-1, TIMP-2) in head and neck squamous cell carcinoma." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514279174.

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Abstract Traditional clinicopathological factors are not accurate enough to predict the behavior of head and neck squamous cell carcinoma (HNSCC). The most powerful indicator of prognosis is the stage of the disease. New prognostic markers have, however, been searched for in order to better identify patient groups in need of different treatments or follow-up. Gelatinases (MMP-2, -9) are endopeptidases associated with tumor invasion and angiogenesis, and their tissue inhibitors (TIMP-1, -2) are also linked to cancer cell invasion and metastasis formation. In some cancer types they are even prog

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13

Timmerman, Alexandra. "Neck ultrasound as a diagnostic method of cervical lymph node metastasis in patients with Head and Neck squamous cell carcinoma." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-55111.

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Recalde-Percaz, Leire. "Neuropilin 2 role in the regulation of disseminated tumour cells dormancy and metastasis in breast and head and neck cancer." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672374.

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Metastases are considered the last stage of tumour progression and the main cause of death associated to solid tumours. There are no effective treatments for metastasis which remain non- curable with more than 90% of patients dying from metastatic disease. They derive from disseminated tumour cells (DTCs) that can remain occult in a dormant state while adapting to the new microenvironment. By mechanisms that are still unclear, dormant DTCs can re-activate and become proliferative giving rise to metastatic outgrowth. Therefore, understanding the mechanisms by which metastases are formed is esse

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15

Jehl, Aude. "Cavéoline-1 prédictive de la métastase et de la rechute locorégionale des cancers des voies aérodigestives supérieures." Thesis, Strasbourg, 2022. http://www.theses.fr/2022STRAJ070.

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Ce projet de recherche translationnelle sur les cancers des voies aérodigestives supérieures (VADS) a permis d’identifier la cavéoline-1 (Cav1) comme un biomarqueur pronostique de l’évolution d’une tumeur primitive des VADS. En effet, une surexpression de cette protéine favorise une rechute locorégionale alors qu’un déficit de Cav1 engage la tumeur vers un processus métastatique. De plus, nous avons mis en évidence l’implication de l’axe Cav1 / EREG / YAP dans la résistance au traitement (cétuximab et radiothérapie). Enfin, nous avons identifié l’épireguline (EREG) comme la protéine clé de la

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16

Marshall, Jocelyn R. "A Study of the Impact of Membrane Organization of Glycosphingolipid E-selectin Ligands and Glycoproteins on Head and Neck Cancer Cell Adhesion to Vascular Endothelium." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1313073422.

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Caggiano, Emily Grace. "Characterization of cold atmospheric plasma treatment as a novel transfection technique to knock down nucleolin in head and neck squamous cell carcinoma." Ohio University Honors Tutorial College / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors155622670397153.

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CHITI, LAVINIA ELENA. "GAMMA-PROBE GUIDED SENTINEL LYMPH NODE EXTIRPATION TO ASSESS PATTERNS OF NODAL METASTASIS IN SPONTANEOUS HEAD AND NECK MALIGNANCIES OF THE DOG: A SECOND STEP BASED ON PREVIOUS EXPERIENCES ON MAST-CELL TUMORS." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/916665.

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Canine oncology has recently reported interest in the detection of occult nodal metastases, and efforts have been made to identify the best strategy for accurate nodal staging. In this scenario, the present PhD thesis was aimed to improve knowledge on the current understanding of the feasibility and impact of sentinel lymph node (SLN) mapping with radiopharmaceutical and blue dye in cancer-bearing dogs. Initially, we evaluated the technique in canine mast cell tumors (MCT), given the high prevalence of this tumor type, the propensity for lymphatic spread and recognized prognostic impact of nod

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19

Roigas, Jan. "Chemoimmuntherapie und immunologische Bedeutung von 70 kiloDalton Hitzeschockproteinen beim metastasierten Nierenzellkarzinom." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=97263438X.

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Vidotto, Alessandra. "Marcadores protéicos do carcinoma epidermóide de cabeça e pescoço com fenótipo invasivo." Faculdade de Medicina de São José do Rio Preto, 2009. http://bdtd.famerp.br/handle/tede/125.

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Made available in DSpace on 2016-01-26T12:51:34Z (GMT). No. of bitstreams: 1 alessandravidotto_tese.pdf: 5410688 bytes, checksum: e1af0ab5bd616652ebf0225cd33f4c1d (MD5) Previous issue date: 2009-08-27<br>The regional lymph nodes play a pivotal role in diagnosis, staging and management of head and neck squamous cell carcinomas (HNSCC). Despite their importance, detailed understanding of the probable mechanisms of lymphatic metastases has not been completely achieved. Subjects and Methods: We analyzed metastatic and normal lymph node tissues, as well as saliva and serum from sixth-two patients

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Gu, Xiaolian. "p63 and epithelial homeostasis studies of p63 under normal, hyper-proliferative and malignant conditions /." Doctoral thesis, Umeå : Umeå university, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33894.

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Paccione, Rachel Josephine. "Vimentin overexpression contributes to the biological properties of metastatic head and neck cancer cells /." 2005. http://hdl.handle.net/10156/1743.

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Yang, Wen-Hao, and 楊文豪. "Investigation of the epithelial-mesenchymal transition independent metastatic mechanism for head and neck cancer." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/33876102856029555757.

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博士<br>國立陽明大學<br>臨床醫學研究所<br>100<br>Head and neck squamous cell carcinoma (HNSCC) represents the sixth most common frequent cancer worldwide. It is one of the major cancers in Taiwan especially for male, and it is the fourth leading cause for male cancer death in Taiwan. Understanding the mechanisms of head and neck cancer metastasis will greatly improve diagnostic or interceptive strategies. EMT was demonstrated to be one of the major mechanisms responsible for mediating invasiveness and metastasis of late-stage cancers. In HNSCC, the hypoxic tumor environment has been shown to be critical to p

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Häußler, Ulrich [Verfasser]. "Effect of ozone-, oxygen-pneumoperitoneum on tumour growth and metastatic spread of the rabbit VX2 head and neck cancer model / vorgelegt von Ulrich Häußler." 2009. http://d-nb.info/993478182/34.

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Pretscher, Dominik [Verfasser]. "Distribution of immune cells in head and neck cancer : CD8+ T-cells and CD20+ B-cells in metastatic lymph nodes are associated with favourable outcome in patients with oro- and hypopharyngeal carcinoma / vorgelegt von Dominik Pretscher." 2010. http://d-nb.info/1000329054/34.

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Tseng, Yen-Ju, and 曾嬿儒. "Effects of Ionizing Radiation on Head and Neck Squamous Cell Carcinoma Metastasis." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/69877977446358271350.

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碩士<br>國立東華大學<br>生命科學系<br>99<br>The death of cancer patients is often due to tumor cell metastasis, therefore the metastasis is an important indicator for cancer diagnosis and treatment. Recent study shows that epithelial mesenchymal transition (EMT) is involved in the process of metastasis. Furthermore, those are a few recent literatures have pointed out that single shot irradiation increases the tumor cell invasion and metastasis, which may be caused by increasing its matrix metalloproteinase (MMPs) activity or hypermethylation of tumor suppressor genes and lost its gene expression and functi

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Ahmedah, H. T., Laurence H. Patterson, Steven D. Shnyder, and Helen M. Sheldrake. "RGD-Binding Integrins in Head and Neck Cancers." 2017. http://hdl.handle.net/10454/12124.

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Yes<br>Alterations in integrin expression and function promote tumour growth, invasion, metastasis and neoangiogenesis. Head and neck cancers are highly vascular tumours with a tendency to metastasise. They express a wide range of integrin receptors. Expression of the αv and β1 subunits has been explored relatively extensively and linked to tumour progression and metastasis. Individual receptors αvβ3 and αvβ5 have proved popular targets for diagnostic and therapeutic agents but lesser studied receptors, such as αvβ6, αvβ8, and β1 subfamily members, also show promise. This review presents the c

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Chen, Li-Hsuen, and 陳立學. "The exploration of epigenetic regulation mediates metastasis in head and neck squamous cell carcinoma." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/42883876504087116896.

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博士<br>國立東華大學<br>生命科學系<br>104<br>Head and neck cancer (HNC) is the sixth common cancer in the world and the fifth cause of cancer death in female and fourth in male in Taiwan. Incidence of HNC has remained stable and the 5-year overall survival rates in HNC is approximately held at 50% for decades. Distant metastasis is found relatively rare but still a major determinant of management and prognosis. The 5-year overall survival rates in HNC may decline to 10% if metastasis is diagnosis. Hence, a better understanding of HNC metastasis and discovering diagnostic biomarkers are urgent for HNC. At t

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CHANG, YU-CHAN, and 張御展. "Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through TRIM24-DDX58 axus." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/dc2cu5.

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博士<br>國防醫學院<br>生命科學研究所<br>105<br>Metabolic reprograming and Warburg effect as an important issue in head and neck squamous cell carcinoma (HNSCC) involved drug-resistance, tumorigenesis and tumor metastasis. Solute Carrie family 2, also called glucose transporter family members play an initial role in glycolysis pathway by controlling transporter efficiency. However, detail mechanism of GLUT family in HNSCC tumorigenesis has not been fully investigated. In our study, GLUT4 had most significant value compared with other family members associating with HNSCC patients’ survival rate. Furthermore,

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Lee, Ming Che, and 李明哲. "Using DWI ADC value to distinguish malignant nodal metastasis from benign in head and neck cancers." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/58978600831053034529.

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博士<br>國立清華大學<br>生醫工程與環境科學系<br>104<br>The detection of cervical nodal metastases is important for the prognosis and treatment of head and neck tumors. The purposes of present study were first to assess the ability of apparent diffusion coefficient (ADC) values at 3.0T to distinguish malignant from benign lymph nodes and second to analyze ADC from partitions through a fuzzy C-means (FCM) technique for distinguishing nodal metastasis in head and neck cancer. From July 2009 to June 2010, 22 patients (21 males and 1 female; mean age, 49.8 ± 9.5 years; age range, 28–66 years) scheduled for surgical

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Chen-HaoHuang and 黃晨豪. "Investigating the role of oleic acid-induced PD-L1 in head and neck squamous cell carcinoma metastasis." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/sp9x6g.

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Shuo-LunWu and 吳碩倫. "Transcriptional activation of pentraxin-3 gene expression is associated with EGF-induced head and neck cancer cell metastasis." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/53100809601694216208.

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碩士<br>國立成功大學<br>生物資訊與訊息傳遞研究所<br>102<br>SUMMARY Overexpression of epidermal growth factor receptor (EGFR) and production of proinflammatroy cytokines are well clarified in head and neck squamous cell carcinoma (HNSCC) and correlates with invasion and metastasis. However, molecular mechanisms by which EGFR-mediated cytokines regulates metastasis of HNSCC remain unclear. Here, we identified that PTX3 is a metastasis-promoting factor that mediate EGF-induced HNSCC metastasis. Analysis of PTX3 expression between normal and malignant or metastatic tissues from HNSCC patients by using published data

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Zhao-LingZheng and 鄭兆良. "The role of PTX3 in anti-cancer drug-induced head and neck squamous cell carcinomas dormancy and metastasis." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/xg2h9q.

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碩士<br>國立成功大學<br>生物科技與產業科學系<br>107<br>Head and neck squamous cell carcinoma (HNSCC) is sixth common cancer in the world. Cisplatin has been used for treatment of many human cancers including head and neck, ovarian and lung cancers. However, the anti-cancer drug resistance and metastasis are needed to be solved to improve the overall survival in patients. Long pentraxin PTX3 is the regulator of innate immune system that is also associated with tumor metastasis. Our previous studies found that the expression level of PTX3 was upregulated in anoikis resistant head and neck squamous carcinoma (HNSC

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Wang, Yi-Fen, and 王怡芬. "The Role of Nm23-H1 in Metastasis Suppression and Cisplatin Sensitivity Enhancement of Head and Neck Squamous Cell Carcinoma." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/12763915506652489985.

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博士<br>國立陽明大學<br>臨床醫學研究所<br>95<br>Head and neck squamous cell carcinoma (HNSCC) represents the sixth most frequent cancer in the worldwide. However, the molecular genetic alterations underlying its malignant behavior and progression are little known. In Taiwan, HNSCC has been the forth or fifth leading cause of cancer death in males since 1991. Despite of early diagnosis and multi-therapeutic modalities, the overall survival has not improved substantially in the last three decades. The major causes of treatment failure are early lymphatic involvement, distant metastasis and chemoradiation resis

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Yu-HanLiao and 廖禹涵. "Angiopoietin-like 4 (ANGPTL4) contributes to Epidermal growth factor (EGF)-stimulated metastasis of head and neck squamous cell carcinoma (HNSCC)." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/39x4qf.

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博士<br>國立成功大學<br>生物科技與產業科學系<br>107<br>Most head and neck cancers are squamous cell types, also called head and neck squamous cell carcinoma (HNSCC). About 75% of head and neck cancer is caused by the use of alcohol or tobacco. Other risk factors such as betel quid, some types of human papillomavirus, radiation exposure, specific workplace exposures, and the Epstein-Barr virus. Early period HNSCC is treated comparatively well with a single-modality therapy (either surgery or radiation alone). However, almost 66% of patients current with advanced sickness, and less than 30% of these patients can

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羅子昀. "Prediction model of cervical lymph node metastasis in head and neck cancer using computed tomography images verified by pathological section." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/k6s32m.

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碩士<br>國立交通大學<br>生物資訊及系統生物研究所<br>107<br>Background：Whether lymph nodes are invaded by cancer cells has a great impact on the follow-up treatment guidelines for patients with head and neck cancer. The current clinical diagnostic method is to make a preliminary judgment in using Computerized Tomography scan images and to confirm the pathological sections for suspected lymph nodes. This is an invasive method that not only has certain risks and injuries to the patient, but also costs money and time. This study proposes a Pred-Meta method, which uses the machine learning algorithm to identify the ly

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Silva, Ana Catarina Guedes. "Cancro oral e a 8ª Edição TNM (Tumor-Nodes-Metastasis)." Master's thesis, 2019. http://hdl.handle.net/10284/9086.

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O cancro oral é uma realidade cada vez mais frequente. O diagnóstico precoce é essencial para que a taxa de sobrevivência aumente. Considera-se cancro oral as neoplasias malignas que afetam a cavidade oral. Neste âmbito, é essencial que os médicos dentistas estejam permanentemente atualizados no que diz respeito a temas como este para que assim, possão o mais precoce e corretamente perante estes casos. “Tumor-Nodes-Metastasis” (TNM) é um sistema internacional de classificação de tumores malignos de forma a uniformizar o seu registo e facilitar a comunicação entre os profissionais de saúde, no

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Jinn-YuanHsu and 許晉源. "The role of cyclooxygenase-2 and pyruvate dehydrogenase kinase 1 in epidermal growth factor-enhanced head and neck squamous cell carcinoma metastasis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/18763576317748547940.

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博士<br>國立成功大學<br>基礎醫學研究所<br>103<br>Epidermal growth factor receptor (EGFR) activation is a major cause of metastasis in many cancers, such as head and neck squamous cell carcinoma (HNSCC). While it is well known that inflammatory factors and metabolic diseases have been associated with the development of cancer, the regulation and functional role of inflammation-triggered cyclooxygenase-2 (COX-2) and metabolic enzyme pyruvate dehydrogenase kinase 1 (PDK1) in EGF-enhanced HNSCC metastasis remain unclear. Interestingly, we found that EGF induced COX-2 and PDK1 expression mainly in HNSCC. The tumo

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Chiu, Li-Wen, and 邱立雯. "AC-0 Inhibits Proliferation and Metastasis of Human Head and Neck Squamous Carcinoma (FaDu-twist) Cells and Suppresses Tumor Growth in Athymic Nude Mice." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/at8y4m.

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Chen, Chen Pei, and 陳貞佩. "A Novel EGFR Inhibitor Exhibits the Therapeutic Efficacy via the Inhibition of Tumor Growth and Metastasis in Human Head and Neck Squamous Cell Carcinoma." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/u2c9n8.

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碩士<br>國立清華大學<br>生物資訊與結構生物研究所<br>105<br>Head and neck squamous cell carcinoma (HNSCC) is the sixth common cancer worldwide and the fifth most common cancer in Taiwan in 2014. Despite various therapeutic strategies were used, the 5-year overall survival rate of locally advanced HNSCC patients is still poor. Thus, investigation of novel therapeutic agents against HNSCC is in urgent need. It was well-characterized that the expression of epidermal growth factor receptor (EGFR) is highly associated with HNSCC pathogenesis and poor prognosis. We recently identified a novel EGFR tyrosine kinase inhibi

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Tehrany, Narges. "Importance of CXCL12 and CXCR4 in radiotherapy of head and neck cancer, considering the association with HPV-infection." Doctoral thesis, 2015. http://hdl.handle.net/11858/00-1735-0000-0023-9616-2.

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Ribeiro, Ilda Patrícia Tavares da Silva. "Head and Neck Squamous Cell Carcinoma: integrating genomic, epigenetic and transcriptomic data - from bench to clinical applications." Doctoral thesis, 2017. http://hdl.handle.net/10316/79613.

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Tese de doutoramento do Programa Interuniversitário de Doutoramento em Envelhecimento e Doenças Crónicas, apresentada à Faculdade de Medicina da Universidade de Coimbra<br>Head and neck squamous cell carcinoma (HNSCC) is an emergent health problem worldwide. These tumors present heterogeneity at phenotypic, aetiological, biological and clinical level. In developed countries, smoking and alcohol are implicated in the increase of HNSCC cases, and human papillomavirus is an important risk factor, especially in the rise of oropharyngeal tumors without smoke and alcohol habits. A significant percen

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