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Artykuły w czasopismach na temat „Micromeritic studies”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

OZYAZICI, M. "Micromeritic studies on nicardipine hydrochloride microcapsules." International Journal of Pharmaceutics 138, no. 1 (1996): 25–35. http://dx.doi.org/10.1016/0378-5173(96)04516-4.

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Sande, T. A., F. J. Sayyad, A. V. Patil, and D. D. Mohite. "FORMULATION AND CHARACTERIZATION OF RITONAVIR LOADED PRONIOSOMES FOR ORAL DRUG DELIVERY." INDIAN DRUGS 54, no. 08 (2017): 46–53. http://dx.doi.org/10.53879/id.54.08.11045.

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Proniosomes of ritonavir were prepared by slurry method using Span 60, maltodextrin and cholesterol. The ratio of concentration of Span 60 to cholesterol was altered while keeping concentration of drug and maltodextrin constant. Prepared formulations were studied for micromeritic properties, entrapment efficiency, particle size, surface morphology and in vitro drug release. Micromeritic properties of all formulations increased as compared to drug and carrier alone. Entrapment efficiency was observed greater than 90 % and drug release was found to be sustained for upto 12 hours in case of all f

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Saritha, Damineni, Penjuri Subhash Chandra Bose, Poreddy Srikanth Reddy, Grandhi Madhuri, and Ravouru Nagaraju. "Improved dissolution and micromeritic properties of naproxen from spherical agglomerates: preparation, in vitro and in vivo characterization." Brazilian Journal of Pharmaceutical Sciences 48, no. 4 (2012): 667–76. http://dx.doi.org/10.1590/s1984-82502012000400010.

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Naproxen, an anti-inflammatory drug, exhibits poor aqueous solubility, which limits the pharmacological effects. The present work was carried out to study the effect of agglomeration on micromeritic properties and dissolution. Naproxen agglomerates were prepared by using a three solvents system composed of acetone (good solvent), water (non-solvent) and dichloromethane (bridging liquid). Differential Scanning Calorimetry (DSC) results showed no change in the drug after crystallization process. X-Ray Powder Diffraction (XRPD) studies showed the sharp peaks are present in the diffractograms of s

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Gupta, Venkadari, Srinivas Mutalik, Madhobhai Patel, and Girish Jani. "Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties." Acta Pharmaceutica 57, no. 2 (2007): 173–84. http://dx.doi.org/10.2478/v10007-007-0014-8.

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Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic propertiesCelecoxib spherical agglomerates were prepared with polyvinylpyrrolidone (PVP) using acetone, water and chloroform as solvent, non-solvent and bridging liquid, respectively. The agglomerates were characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), IR spectroscopic studies and scanning electron microscopy (SEM). The IR spectroscopy and DSC results indicated the absence of any interactions between drug and additives. XRD studies showed a decrease in crystallinity in a

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Nijhawan, Monika, Rajeswari Aleti, Sailaja Gunnam, and Sneha Nawale. "SPHERICAL AGGLOMERATION OF TELMISARTAN - AN APPROACH TO IMPROVE PHYSICOCHEMICAL PROPERTIES." INDIAN DRUGS 61, no. 08 (2024): 38–43. http://dx.doi.org/10.53879/id.61.08.14698.

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The study explains the preparation of spherical agglomerates (SA) of telmisartan (TLS), a BCS class II drug used to improve it’s physicochemical and bulk properties. Drugs of this class could potentially exhibit dissolution rate limited absorption. TLS spherical agglomerates were designed using hydrophilic polymer (PVP K-30), dimethyl formamide (DMF), water and ethyl acetate (bridging liquid) by solvent change method and evaluated for micromeritic properties. The SA were characterized by particle size determination, FTIR, PXRD and SEM. The results of micromeritic studies indicated that SA show

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Umoh, Romanus A., Imoh I. Johnny, Nsima A. Andy, Anwanabasi E. Udoh, Trust E. Ekpo, and Gabriel U. Ashibeshi. "Micromorphological and Pharmacognostic Studies of Mussaenda philippica L. Flower." Journal of Complementary and Alternative Medical Research 23, no. 4 (2023): 1–11. http://dx.doi.org/10.9734/jocamr/2023/v23i4483.

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Mussaenda philippica Linn. belongs to the sub-family Ixoroideae which belongs to the family Rubiaceae. The aim of this study was to employ the quality control parameters in the evaluation of flowers of M. philippica L. The flowers were collected, identified, air dried and pulverized. Standard procedures were carried out to obtain microscopic features of the fresh and powdered samples, micromeritic, chemomicroscopy, flourescence properties, soluble-extractive values, moisture content and ash values. The results of the microscopic studies using the fresh and powdered flower revealed the presence

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Saikia, Trideep, Jonab Ali, and Biswajit Das. "ISOLATION AND CHARECTERIZATION OF TAMARIND SEED POLYSACCHARIDES–A NATURAL RELEASE RETARDANT." International Journal of Current Pharmaceutical Research 9, no. 4 (2017): 114. http://dx.doi.org/10.22159/ijcpr.2017v9i4.20972.

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Objective: The main objective was to isolate and characterise a naturally obtain polysaccharides which have the property to formulate sustain release product.Methods: Tamarind Seed Polysaccharides (TSP) was isolated from seed of Tamarindus indica by crushed the seed into powder and boiled with water at 45 °C to extract the polysaccharides. After boiling for 12 h the supernatant liquids were collected and stored in cool place. After the liquids become cooled acetone was added and freeze at-40 °C. Freeze materials then lyophilized to extract out the Tamarind seed polysaccharides. After that poly

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Venkateswarlu, Kambham. "Evaluation of glibenclamide microspheres for sustained release." Journal of Pharmacy & Pharmacognosy Research 5, no. 1 (2017): 78–87. http://dx.doi.org/10.56499/jppres16.156_5.2.78.

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Context: Sustained release drug delivery systems are more preferred than the conventional drug delivery systems due to its enhanced bioavailability and patient compliance. Earlier studies reported on glibenclamide (GBCM) were not clear and hence, the step has been taken to explore the sustained release drug delivery system of GBCM. Aims: To evaluate the sustained release microspheres obtained of GBCM. Methods: Microspheres were prepared by ionic gelation method using the polymers like Eudragit RS 100 and xanthan gum. Polymers can sustain the drug release from microspheres. The prepared microsp

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9

Siddheshwar, Suhas S., Kiran R. Dushing, and Someshwar D. Mankar. "FORMULATION AND EVALUATION OF CEFDITOREN PIVOXIL GRANULES FOR ORAL USE." INDIAN DRUGS 61, no. 12 (2024): 37–42. https://doi.org/10.53879/id.61.12.14845.

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Cefditoren pivoxil is used in the treatment of various bacterial infections. It exhibits a strong bitter taste on oral administration. Thus, there is a need that the bitter taste of cefditoren pivoxil should be minimized to such an extent that the oral administration of cefditoren pivoxil would be palatable to patients. The study reported here aimed to develop cefditoren pivoxil granules by dry granulation technique, characterize them for micromeritic properties, to mask the bitterness of the drug and undertake in vitro drug release studies. The pre-formulation studies were carried out using H

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10

Abali, S. Okorie, C. Ekenna Ifeoma, and Faithfulness Ochen. "Formulation and Characterization of Extended-Release Nevirapine Solid Dispersions Running Title: Extended Release Nevirapine Solid Dispersions." International Journal of Innovative Science and Research Technology 7, no. 3 (2022): 588–94. https://doi.org/10.5281/zenodo.6406164.

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The bioavailability of a drug is usually determined by its aqueous solubility and lipid permeability. Nevirapine is an antiretroviral drug that belongs to the BCS II with poor solubility but high permeability. This study was carried out to improve the dissolution of nevirapine and also to formulate extended-release nevirapine tablets. Nevirapine: PEG 4000 were combined in different ratios to produce physical mixtures and solid dispersions. Micromeritics studies were carried out on the particles of the solid dispersions and the physical mixtures. These physical mixtures and solid dispersions we

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Abali, S. Okorie, C. Ekenna Ifeoma, and Faithfulness Ochen. "Formulation and Characterization of Extended-Release Nevirapine Solid Dispersions Running Title: Extended Release Nevirapine Solid Dispersions." International Journal of Innovative Science and Research Technology 7, no. 3 (2022): 588–94. https://doi.org/10.5281/zenodo.6406166.

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The bioavailability of a drug is usually determined by its aqueous solubility and lipid permeability. Nevirapine is an antiretroviral drug that belongs to the BCS II with poor solubility but high permeability. This study was carried out to improve the dissolution of nevirapine and also to formulate extended-release nevirapine tablets. Nevirapine: PEG 4000 were combined in different ratios to produce physical mixtures and solid dispersions. Micromeritics studies were carried out on the particles of the solid dispersions and the physical mixtures. These physical mixtures and solid dispersions we

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12

Khan, Mohammed S., Gowda D. Vishakante, and H. G. Shivakumar. "Porous nanoparticles of metoprolol tartrate produced by spray-drying: development, characterization and in vitro evaluation." Acta Pharmaceutica 62, no. 3 (2012): 383–94. http://dx.doi.org/10.2478/v10007-012-0021-2.

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The present investigation was undertaken to fabricate porous nanoparticles of metoprolol tartrate by spray-drying using ammonium carbonate as pore former. Prepared nanoparticles were coated with Eudragit S100 polymer in order to prevent the release of metoprolol tartrate in the upper GI tract. It was shown that nanoparticles with low size ranges can be obtained with a low feed inlet rate. Micromeritic studies confirmed that nanoparticle batches are discrete and free flowing. Effects of the pore former on drug loading, porosity and in vitro release were studied. It was found that there was an i

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13

Ozyazici, Mine, Ferhan Sevgi, Cetin Pekcetin, Buket Sarpas, and Safak Sayin. "Sustained release spherical agglomerates of polymethacrylates containing mefenamic acid:in vitrorelease, micromeritic properties and histological studies." Pharmaceutical Development and Technology 17, no. 4 (2011): 483–893. http://dx.doi.org/10.3109/10837450.2010.550621.

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Ertan, G., Ö. ÖZer, E. Balôlu, and T. Güner. "Sustained-release microcapsules of nitrofurantoin and amoxicillin; preparation,in-vitrorelease rate, kinetic and micromeritic studies." Journal of Microencapsulation 14, no. 3 (1997): 379–88. http://dx.doi.org/10.3109/02652049709051140.

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J, Hasiful Arabi, Subramanian L, Rajesh M, and Arun Kumar MS. "Effect of Different Stabilizers on Spherical Agglomerates of Montelukast Sodium by Quasi Emulsion Solvent Diffusion (QESD)." International Journal for Research in Applied Science and Engineering Technology 11, no. 7 (2023): 2136–45. http://dx.doi.org/10.22214/ijraset.2023.55074.

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Abstract: The present study was focused on the spherical crystallization of an asthmatic drug, Montelukast Sodium (MLS) using quasi emulsion solvent diffusion (QESD) technique in which distilled water was an external phase and the internal phase consisted of Ethanol which acts as good solvent and Ethyl acetate as a bridging liquid for recrystallization and agglomeration process. Apart from being poorly water soluble, MLS exhibits poor flow and compressibility. The spherical agglomeration was carried out in the presence of different stabilizers like acacia, PEG 4000, sodium lauryl sulphate, spa

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Parasuramudu, Samudram, and N. Sai Gowthami. "Development and Evaluation of Controlled Release Matrix Microspheres of Doxazosin using HPMC and Carbopol." International Journal of Enhanced Research in Medicines & Dental Care 12, no. 07 (2025): 21–33. https://doi.org/10.55948/ijermdc.2025.0704.

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Objective: This study aims to develop and evaluate controlled release matrix microspheres of Doxazosin, a poorly water-soluble antihypertensive drug, to overcome limitations associated with conventional oral dosage forms, including fluctuating plasma levels and frequent dosing. Methods: Microspheres were formulated using Hydroxypropyl Methylcellulose (HPMC K15) and Carbopol via the emulsion solvent evaporation technique. A series of ten formulations were developed and characterized for drug entrapment efficiency, mean particle size, micromeritic properties, and in-vitro drug release. FTIR and

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D., V. Chaudhary* S.D. Pande &. .N. G. Dumore. "DESIGN AND CHARACTERIZATION OF POLYMERIC MICROSPHERES FOR ORAL ADMINISTRATION." INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY 4, no. 7 (2017): 26–38. https://doi.org/10.5281/zenodo.835676.

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An appropriately designed sustained or controlled release drug delivery system can be a major advance towards solving the problem associated with the existing drug delivery system. Microspheres as a novel drug delivery system for oral administration are having the feasibility of carrying the drug. These are the monolithic spheres or therapeutic agent distributed throughout the matrix as a molecular dispersion of particles. Rational behind the drug encapsulation into microspheres is preparation of suitable formulation with longer duration of action for control release thereby sustaining the rol

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Manivannan, Subramanian, Akshay M, Bhuvaneswari S, and Nify F. "FORMULATION AND EVALUATION OF GASTRORETENTIVE MICROBALLOONS OF ACEBROPHYLLINE FOR THE TREATMENT OF BRONCHIAL ASTHMA." Asian Journal of Pharmaceutical and Clinical Research 9, no. 5 (2016): 105. http://dx.doi.org/10.22159/ajpcr.2016.v9i5.12603.

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ABSTRACTObjective: Gastroretentive dosage forms are an approach for prolonged and predictable drug delivery in the upper gastrointestinal tract to controlthe gastric residence time. Microballoons are considered as one of the most promising buoyant drug delivery systems as they possess the advantagesof both multiple-unit systems and good floating properties. Acebrophylline is a xanthine derivative with potent bronchodilator, mucosecretolytic, andanti-inflammatory property. It is used to treat bronchial asthma and chronic obstructive pulmonary diseases.Methods: Microballoons of acebrophylline we

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Alladi, saritha and Rebecca Sanjana. "FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF RANOLAZINE EXTENDED RELEASE TABLETS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 01 (2018): 682–87. https://doi.org/10.5281/zenodo.1170150.

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The ranolazine extended release tablets can be prepared by wet granulation method using different polymers in varying combinations. Tablet blends were prepared and micromeritic studies were carried out for those blends and found to be within the limits. Compatability studies were carried out and found that drugs and excipients are compatible with each other. Post compression parameters were carried out found to be within the limits. Also dissolution data of all formulations reveals that as combination of Compritol, Carbopol934P increases the percentage drug release was found to be increased Fo

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Igharo, Aiseosa Kingsley, Didacus Nnamani, Adedokun Oluwasegun, and Kehinde Ibrahim. "Gum Arabic microencapsulated Spondia mombin particles induced delayed modulatory potential on testosterone-induced benign prostatic hyperplasia." Journal of Current Biomedical Research 4, no. 5 (2024): 1804–35. https://doi.org/10.54117/jcbr.v4i5.4.

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Spondia mombin stems are traditionally used for managing benign prostatic hyperplasia (BPH). This study examines the impact of microencapsulation on S. mombin’s anti-BPH properties, comparing the crude and encapsulated extracts. Microencapsulated particles of S. mombin (S-Mp) were prepared using acacia gum and characterized through Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), Fourier Transform Infrared Spectroscopy (FTIR), micromeritic analysis, and dissolution studies. The anti-BPH activity of S-Mp, blank particles (B-Mp), and crude extracts was evaluated in vivo by meas

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Umoh, Romanus A., Imoh I. Johnny, Nsima A. Andy, et al. "Pharmacognostic Evaluation of the Leaves of Thurnbegia laevis Nees (Acanthaceae)." Asian Journal of Biochemistry, Genetics and Molecular Biology 15, no. 3 (2023): 91–103. http://dx.doi.org/10.9734/ajbgmb/2023/v15i3342.

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Thurnbegia laevis Nees. belong to the Acanthaceae family. It is used in folklore medicine for the management of diabetes, piles, joint pains as well as skin related problems. This study aims to evaluate the leaves of the plant by employing the quality control parameters. The leaves of T. laevis were collected, identified, air-dried, pulverized and stored in glass bottles. Standard procedures were used to carry out microscopy on the fresh leaves, micromeritics, chemomicroscopy, fluorescence analysis, soluble-extractive values, moisture contents and ash values using powdered samples of the leaf.

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Dnyandeo Tambe, Bhavana. "Development and Evaluation of Alginate Microspheres of Paracetamol: Effect of Different Concentrations of Cross linking Agent and Coating." Asian Journal of Pharmaceutical Research and Development 9, no. 3 (2021): 39–42. http://dx.doi.org/10.22270/ajprd.v9i3.968.

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The present work is to formulate the mucoadhesive microspheres loaded Paracetamol using calcium chloride as a cross linking agent by isotropic gelatin method. The study focused on the effect of different concentrations of cross linking agent and coating on the dissolution profile of Microspheres using sodium carboxy methyl cellulose (SCMC) as coating agent. Microspheres were prepared by using 2% sodium alginate aqueous solution with three different concentrations (5%, 10%, 15% w/v) of cross linking agent (CaCl2), followed by coating with 2% sodium carboxy methyl cellulose (low viscosity grade)

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Talari, Roya, Ali Nokhodchi, Seyed Abolfazl Mostafavi, and Jaleh Varshosaz. "Dissolution Enhancement of Gliclazide Using pH Change Approach in Presence of Twelve Stabilizers with Various Physico-Chemical Properties." Journal of Pharmacy & Pharmaceutical Sciences 12, no. 3 (2009): 250. http://dx.doi.org/10.18433/j31p4p.

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Purpose: The micronization using milling process to enhance dissolution rate is extremely inefficient due to a high energy input, and disruptions in the crystal lattice which can cause physical or chemical instability. Therefore, the aim of the present study is to use in situ micronization process through pH change method to produce micron-size gliclazide particles for fast dissolution hence better bioavailability. Methods: Gliclazide was recrystallized in presence of 12 different stabilizers and the effects of each stabilizer on micromeritic behaviors, morphology of microcrystals, dissolution

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Kodalkar, Swapnil J., Rohan A. Khutale, Sachin S. Salunkhe, Sachin S. Mali, and Sameer J. Nadaf. "Implementation of time release technology in formulation development and evaluation of sustained release tablet of Lornoxicam." Indian Journal of Pharmaceutical and Biological Research 2, no. 01 (2014): 68–75. http://dx.doi.org/10.30750/ijpbr.2.1.11.

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In present study, the attempts have been made to formulate sustained release tablets of lornoxicam by direct compression method. Based on viscosity grades different proportions of hydrophilic polymers (HPMC K4M, HPMC K15M, HPMC K100M) are used for preparation of lornoxicam sustained release matrix tablet. The drug excipient mixtures were subjected to preformulation studies comprising of micromeritic properties. The tablets were subjected to various studies like as physicochemical studies, in vitro drug release, kinetic studies, etc. FTIR studies shown there was no interaction between drug and

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Divyashree, P.1 Nagendra R.2 Nanditha V. V.3 Venkatesh4 K. Hanumanthachar Joshi5. "Formulation And Evaluation of Floating Drug Delivery System of Benazepril." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 351–61. https://doi.org/10.5281/zenodo.14050296.

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The research focuses on developing a floating drug delivery system for Benazepril, aimed at enhancing its absorption and prolonging gastric residence time, thereby improving bioavailability. Floating drug delivery systems (FDDS) maintain buoyancy in gastric fluids, allowing for extended action and reduced dosing frequency. The formulation of floating tablets utilized Carbopol 940, Guar gum, and HPMC K100M as polymers through direct compression, resulting in nine Formulations (F1-F9). Preformulation parameters adhered to pharmacopoeial standards, and FTIR studies confirmed no incompatibility be

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Jain, Neha, Mohan L. Kori, Umesh K. Jain, and Abhishek K. Jain. "NATURAL BIODEGRADABLE CIPROFLOXACIN MICROSPHERES: OPTIMIZATION STUDY BY FACTORIAL DESIGN." Indian Drugs 59, no. 04 (2022): 24–33. http://dx.doi.org/10.53879/id.59.04.13018.

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Oral drug delivery is the most popular method of control and release of therapeutic agents for the management of diseases. The colon specific drug delivery systems are considered to attain targeted drug delivery to the large intestine specifically at colon. They provide local delivery for the treatment of colonic diseases like inflammatory bowel disease. The present investigation is based on response of percent drug release as dependent variable for the study at Y axis with two different variables-concentration of surfactant (X1) and stirring speed (X2). A 32 full factorial design was used for

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Gowripattapu, Sridevi, Anusha Nallamilli, and Ashokbabu K. S. "FORMULATION AND EVALUATION OF CAPTOPRIL BIOADHESIVE MICROSPHERES." INDIAN DRUGS 58, no. 09 (2021): 70–72. http://dx.doi.org/10.53879/id.58.09.12410.

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In the present work, captopril microspheres using HPMCK100M, HPMCK15M and Carbopol 934 as copolymers were formulated by ionic cross linking technique (ionotropic gelation method) to deliver captopril via oral route. The technique was successfully employed to fabricate captopril microspheres and provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system and thus avoids residual solvents in microspheres. Other methods utilize larger volume of organic solvents are costly and hazardous. Micromeritic studies revealed that the mean particle size wa

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Kruthi, Gurudev, B. V. Basavaraj, S. Bharath, R. Deveswaran, and V. Madhavan. "SUSTAINED RELEASE MULTIPARTICULATE GASTRORETENTIVE DELIVERY SYSTEM OF CINNARIZINE." INDIAN DRUGS 51, no. 07 (2014): 31–38. http://dx.doi.org/10.53879/id.51.07.10109.

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The main aim of the present work was to formulate and evaluate sustained release multiparticulate gastroretentive delivery system of cinnarizine. The microspheres were prepared by solvent evaporation method by using Eudragit RS 100 as a polymer in varying ratios. The prepared microspheres were evaluated for drug – polymer compatibility studies, micromeritic properties, drug entrapment efficiency, in vitro buoyancy and drug release studies. The mean particle size increased with increase in polymer concentration, ranging between 60.33 μm to 144.88 μm. FT IR studies showed that the drug and polym

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Kruthi, Gurudev, B. V. Basavaraj, S. Bharath, R. Deveswaran, and V. Madhavan. "SUSTAINED RELEASE MULTIPARTICULATE GASTRORETENTIVE DELIVERY SYSTEM OF CINNARIZINE." INDIAN DRUGS 51, no. 07 (2014): 31–38. http://dx.doi.org/10.53879/id.51.07.10109.

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The main aim of the present work was to formulate and evaluate sustained release multiparticulate gastroretentive delivery system of cinnarizine. The microspheres were prepared by solvent evaporation method by using Eudragit RS 100 as a polymer in varying ratios. The prepared microspheres were evaluated for drug – polymer compatibility studies, micromeritic properties, drug entrapment efficiency, in vitro buoyancy and drug release studies. The mean particle size increased with increase in polymer concentration, ranging between 60.33 μm to 144.88 μm. FT IR studies showed that the drug and polym

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PADMA PRIYA, S., AN Rajalakshmi, and P. Ilaveni. "FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF AN ANTI-MIGRAINE DRUG." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 465–74. http://dx.doi.org/10.22270/jddt.v8i5.1943.

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Objective: The objective of this research work is to develop and evaluate mucoadhesive microspheres of an anti-migraine drug for sustained release. Materials and Methods: Mucoadhesive microspheres were prepared by emulsification method using Sodium alginate (SA), polyvinyl pyrrolidone (PVP) and Chitosan in the various drug-polymer ratios of 1:1, 1:2 and 1:3. Nine formulations were formulated and evaluated for possible drug polymer interactions, percentage yield, micromeritic properties, particle size, drug content, drug entrapment efficiency, drug loading, swelling index, In-vitro wash off tes

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Mishra, Himanshu, Lokesh Adhikari, Mona Semalty, and Ajay Semalty. "CELLULOSE ACETATE FLOATING MICROSPHERES OF METFORMIN HYDROCHLORIDE: FORMULATION AND CHARACTERIZATION." INDIAN DRUGS 57, no. 12 (2021): 65–69. http://dx.doi.org/10.53879/id.57.12.12742.

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In this study, floating microspheres of metformin hydrochloride were prepared by using cellulose acetate polymer by solvent evaporation method. Four formulations were prepared by varying the ratio of drug and polymer. The prepared microspheres were then subjected to various evaluation parameters such as drug content, micromeritic evaluations, FTIR, SEM, floatability and in vitro dissolution study. Formulation F1 (1:1 ratio of polymer and drug) showed the highest drug release and drug content with good flow properties. The cumulative percentage of drug release significantly decreased with decre

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Ovenseri, Airemwen Collins, and Uhumwangho Uwumagbe Michael. "Formulation of Non-effervescent Floating Dosage Form of Metronidazole using Sintering and Sublimation Technique." Dhaka University Journal of Pharmaceutical Sciences 20, no. 1 (2021): 11–17. http://dx.doi.org/10.3329/dujps.v19i2.50853.

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The aim of this study was to formulate a novel non-effervescent floating dosage form of metronidazole using the sublimation and sintering technique. Granules were formulated using the wet granulation technique. Ammonium bicarbonate (30% w/w) was incorporated as the sublimating agent. The granules were characterized for micromeritic properties. Thereafter, the granules were compressed using a single punch tableting machine and the physicotechnical properties were evaluated. The metronidazole tablet was then sintered at 70oC for 12 h. All granules were free flowing and compressible. The metronid

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Tamboli, Firoj A., Asavari R. Rasam, Sweta S. Patil, et al. "Extraction and characterization of opuntia stricta cladodes mucilage as pharmaceutical excipient." International Journal of Pharmaceutical Chemistry and Analysis 9, no. 3 (2022): 134–37. http://dx.doi.org/10.18231/j.ijpca.2022.025.

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This study deals with extraction and characterization of mucilage extracted from cladodes of Cactus () as pharmaceutical excipient. With the use Acetone based extraction method, the yield of mucilage was found to be 1.44%. Characterization of the extracted mucilage was done by various parameters such as micromeritic studies, flow behavior, organoleptic properties, surface tension and viscosity, loss on drying, ash value and swelling index. The result showed that extracted mucilage exhibited good flow properties (Angle of repose 25.30°), the surface tension of 2.85% w/v solutions of mucilage wa

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Lavate, Smita A., and Rohit R. Shah. "DESIGN AND EVALUATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR DEFERASIROX." INDIAN DRUGS 61, no. 10 (2024): 45–56. https://doi.org/10.53879/id.61.10.14345.

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In order to increase deferasirox’s (DEF) solubility and dissolution rate, the study aims to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS). The impact of concentrations of oil and surfactant on emulsification and in vitro drug release was investigated using an oil, surfactant and cosurfactant mixture. Based on a minimum time of emulsification and a high cumulative percentage of drug dissolution, the formulation F6 was optimized. The optimized formulation showed an emulsification efficiency of 19 ± 0.67 seconds and in vitro drug release of 98.65 ± 0.259 % in 30 minutes. Ne

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Muhammad Zaman, Muhammad Zaman, Muhammad Hanif Muhammad Hanif, Syed Saeed Ul Hassan Syed Saeed Ul Hassan, and Javed Iqbal and Muhammad Ahmad Shehzad Javed Iqbal and Muhammad Ahmad Shehzad. "Beta-Cyclodextrin and Maltodextrin Based Solid Dispersion of Meloxicam to Enhance the Solubility of Meloxicam; Formulation and In-vitro Evaluation." Journal of the chemical society of pakistan 41, no. 1 (2019): 133. http://dx.doi.org/10.52568/000718/jcsp/41.01.2019.

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The purpose of the current study was to enhance the solubility of the meloxicam (MLX) by preparing complex with β-Cyclodextrin (CD) and maltodextrin (MD). Dextrins have the ability to capture the drug inside their cavities without forming any chemical bonding. Three (3) formulations, each of solid dispersion (SD) and physical mixture (PM) were prepared by using different drug to polymer ratios (1:4, 1:6 and 1:8) followed by evaluation for micromeritic properties, drug contents, and in vitro drug release studies, scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and x-

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Medipelli, Anitha, and Praveena Chinthala. "Formulation and In-Vitro Assessment of Torsemide -Loaded Microspheres for Controlled Drug Delivery." Biosciences Biotechnology Research Asia 21, no. 4 (2024): 1605–14. https://doi.org/10.13005/bbra/3329.

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ABSTRACT: The present work aimed at formulation development and evaluation of Torsemide (TOR) microspheres. The loop diuretic TOR is used to treat congestive heart failure and edema. Due to its short half-life of two to three hours, weak basicity, and high solubility, TOR is released rapidly and does not provide sustained drug release. To achieve controlled drug release at a predetermined rate, TOR was prepared into microspheres. A total of 12 formulations were prepared by combining Sodium alginate with varying proportions of the polymers Eudragit RL100 and Hydroxy propyl methyl cellulose K15

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S., Nivetha* S. K. Senthilkumar R. Bharathi S. Bhuvana S. M. Deena J. Hari Haran. "Formulation And Evaluation of Miglustat Sustained Release Matrix Tablet in The Treatment of Gaucher's Disease." International Journal of Pharmaceutical Sciences 3, no. 2 (2025): 1076–83. https://doi.org/10.5281/zenodo.14871268.

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Gaucher disease is a rare lysosomal storage disorder caused by a deficiency in the enzyme glucocerebrosidase, leading to the accumulation of glucocerebroside in organs such as the spleen, liver, and bone marrow. Current treatment strategies include enzyme replacement   therapy (ERT) and substrate reduction therapy (SRT), with Miglustat being a key oral therapeutic agent. This study focuses on developing a sustained-release matrix tablet formulation of Miglustat to enhance its therapeutic efficacy and patient compliance.The formulation was prepared using the direct compression method,

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Kumar, Balagani Pavan, Irisappan Sarath Chandiran, and Korlakunta Narasimha Jayaveera. "Formulation development and evaluation of Glibenclamide loaded Eudragit RLPO microparticles." International Current Pharmaceutical Journal 2, no. 12 (2013): 196–201. http://dx.doi.org/10.3329/icpj.v2i12.17016.

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The objective of the present investigation was to formulate and evaluate microencapsulated Glibenclamide produced by the emulsion solvent evaporation method. Microparticles were prepared using Eudragit RLPO by emulsion solvent evaporation method and characterized for their micromeritic properties, encapsulation efficiency, particle size, drug loading, FTIR, DSC, SEM analysis. In vitro release studies were performed in phosphate buffer (pH 7.4). Stability studies were conducted as per ICH guidelines. The resulting microparticles obtained by solvent evaporation method were free flowing in natu

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Umamaheswara Rao T, Smitha M, Maghiben M, and Damodara Velayudham A. "Analysis on the evaluation of aceclofenac bilayer tablets and its formulation using FT-IT method." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 323–28. http://dx.doi.org/10.26452/ijrps.v11ispl4.3798.

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The detached of the current research progress a bilayer tablet of aceclofenac utilizing sodium starch glycolate (SSG) and croscarmellose sodium (CCS) as super disintegrants for the formulation of immediate-release layer whereas polymers such as methocel K15M, Lubrizol 971P were utilized by the formulation of sustaining layer. The tablets were equipped by straight density technique. The organized tablets were estimated for pre-compressed parameters like micromeritic properties and post compressed parameters like bulk variation, aceclofenac satisfied and in-vitro dissolution studies. The in-vitr

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Anusha, V., MS Umashankar, and Y. Ganesh Kumar. "Preformulation Studies of Pitavastatin Calcium– A Primary Step in Further Design of Chronotherapeutic Formulation Synchronized with Circadian Rhythm." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 03 (2024): 1578–85. http://dx.doi.org/10.25258/ijddt.14.3.46.

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The principal goal and objective of this present research work were to perform a preformulation analysis of Pitavastatin calcium to produce a further stable, efficient chroomodulated drug delivery system. Pitavastatin calcium was analyzed to study its micrometric properties, equilibrium solubility profile in different media, and determination of purity by subjecting to fouriertransform infrared spectroscopy (FTIR) studies, by determining the absorption maxima in the medium along with differential scanning Calorimetry- DSC. Spectral analysis of UV studies and calibration curve plotting was done

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Bansal, Mukesh, Dilip Kumar Gupta, Monika Sachdeva, and ,. Kamini. "Formulation and Characterization of Expandable Tablet of Diacerein using Swellable Polymers." Journal of Drug Delivery and Therapeutics 12, no. 5 (2022): 156–69. http://dx.doi.org/10.22270/jddt.v12i5.5612.

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Some of the drugs have poor absorption because of a narrow absorption window in the gastrointestinal tract (GIT). To improve the absorption of such drugs in the GIT, gastro-retentive drug delivery techniques play an important role. Diacerein is an antirheumatic drug used for joint pain and arthritis. The expandable gastro-retentive tablets were prepared to attain an extended therapeutic action of Diacerein. Expandable tablets were formulated to prolong gastric retention, enhance the bioavailability of the drug candidate and attain a desirable size greater than the diametric size of the pyloric

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Sarfaraz Md, Sarfaraz Md, Irfan Alam Shabbir Khan, and H. Doddayya H. Doddayya. "“Design and Characterization of Porous Floating Beads of Lafutidine”." Journal of Research in Pharmaceutical Science 10, no. 11 (2024): 15–17. https://doi.org/10.35629/2995-10110517.

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The aim of present research work was to design and characterize porous floating beads of lafutidine a second-generation H2–receptor antagonist. Using the emulsion gelation method, Lafutidine porous floating beads were meticulously crafted, incorporating hydrophilic polymers such as sodium alginate (serving as the gelling agent), along with hydroxypropyl methylcellulose K15M, hydroxypropyl methylcellulose K4M and Carbopol 934p as polymers. Calcium carbonate was introduced as the gas-generating agent, while calcium chloride played the crucial role of the cross-linking agent. The effect of differ

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Hameed, Huma, Khurram Rehman, Anam Hameed, and Abdul Qayuum. "Preparation and characterization of pH-responsive ionic crosslinked microparticles of mercaptopurine to target ulcerative colitis." Polymers and Polymer Composites 29, no. 9_suppl (2021): S1248—S1256. http://dx.doi.org/10.1177/09673911211047338.

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The objective of this study was the preparation of ionically crosslinked 6-mercaptopurine (6-MP) monohydrate microparticles through preparing polyelectrolyte complexes of drug and polymers. Polymers such as chitosan, casein, and carrageenan were used to prepare crosslinked microparticles, and sodium tripolyphosphate was used as crosslinker. Microparticles were characterized for their flow behavior, compressibility, percentage yield, micromeritic, and entrapment efficiency. Scanning electron microscopy was conducted to understand the surface morphology of the microparticles, and the result was

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WAGHMARE, SHUBHAM M., NAMRATA N. MORE, SURAJ R. JAGTAP, TRUSHALI A. MANDHARE, GAURAV K. SONI, and AJAY Y. KALE. "TECHNIQUES AND EVALUATION TESTS FOR COLON CANCER TREATMENT USING PELLETS: A REVIEW." Current Research in Pharmaceutical Sciences 13, no. 4 (2024): 157–66. http://dx.doi.org/10.24092/crps.2023.130401.

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This review outlines the manufacturing process for globular pellets. The production method includes the following steps: drug stacking, displacement-merumerization, cryopelletization, shrink, balling, hot-soften extrusion generation, freeze pelletization, spray-drying, and spray-congealing. The benefits and risks of several pelletization methods were discussed. The current study's objective is to examine the efficacy of anticancer drugs and metal chelators in treating colorectal cancer (CRC). Phytic acid, 5-fluorouracil (5-FU), microcrystalline cellulose (MCC) PH 100 and 1 compile in the pelle

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M, Alagusundaram, Ashokkumar S, Gokulnath M, Jeeva M, Velmurugan S, and NeelaveniThangavelk Thangavel. "Formulation and evaluation of curcumin-loaded superporous hydrogels." Future Journal of Pharmaceuticals and Health Sciences 5, no. 1 (2025): 119–26. https://doi.org/10.26452/fjphs.v5i1.721.

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The development of curcumin-loaded superporous hydrogels represents a systematic approach to enhancing curcumin’s therapeutic potential. Superporous hydrogels were successfully synthesized using chitosan, sodium alginate, and polyvinyl alcohol, crosslinked with glyoxal and calcium chloride. This process resulted in stable formulations with satisfactory micromeritic properties. The swelling behavior of the hydrogels was significantly influenced by polymer concentration and crosslinking density, with the formulation labeled CS4 exhibiting the highest swelling capacity. Physicochemical evaluation

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Corrie, Leander, Jaskiran Kaur, Ankit Awasthi, et al. "Multivariate Data Analysis and Central Composite Design-Oriented Optimization of Solid Carriers for Formulation of Curcumin-Loaded Solid SNEDDS: Dissolution and Bioavailability Assessment." Pharmaceutics 14, no. 11 (2022): 2395. http://dx.doi.org/10.3390/pharmaceutics14112395.

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The study was initiated with two major purposes: investigating the role of isomalt (GIQ9) as a pharmaceutical carrier for solid self-nanoemulsifying drug delivery systems (S-SNEDDSs) and improving the oral bioavailability of lipophilic curcumin (CUN). GIQ9 has never been explored for solidification of liquid lipid-based nanoparticles such as a liquid isotropic mixture of a SNEDDS containing oil, surfactant and co-surfactant. The suitability of GIQ9 as a carrier was assessed by calculating the loading factor, flow and micromeritic properties. The S-SNEDDSs were prepared by surface adsorption te

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Rahul, Mante* Dr. R. S. Radke Dr. Aijaz Sheikh Dr. K. R. Biyani. "Formulation And Evaluation of Pulsatile Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2369–79. https://doi.org/10.5281/zenodo.15417701.

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Pulsatile drug delivery systems (PDDS) are designed to release drugs in a transient manner, following a predetermined lag time, to synchronize with the body's circadian rhythms or specific biological events. This study aimed to develop and evaluate a press-coated pulsatile tablet of Telmisartan, a drug commonly used to treat hypertension, where blood pressure typically peaks in the morning. Preformulation studies confirmed the drug's purity and solubility profile, with UV spectroscopy determining the maximum wavelength at 295 nm. Standard calibration curves were linear (2-18 µg/ml) in a

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D. V. R. N., Bhikshapathi, and Kanteepan P. "Formulation and In Vivo Evaluation of Mucoadhesive Micro-spheres of Rebamipide, a Mucoprotective Drug for GIT Disorders." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 3 (2018): 4089–97. http://dx.doi.org/10.37285/ijpsn.2018.11.3.2.

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Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. The current research study aimed to develop novel gastro-retentive mucoadhesive microspheres of rebamipide using ionotropic gelation technique. Studies of micromeritic properties confirmed that microspheres were free flowing with good packability. The in vitro drug release showed the sustained release of rebamipide up to 99.23 ± 0.13% within 12 h whereas marketed product displayed the drug release of 95.15 ± 0.23% within 1 h. The release mech

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Obarisiagbon, J. A., O. A. Folorunsho, S. O. Eraga, C. O. Airemwen, and A. M. Adeniyi-Akee. "Evaluation of the binding properties of pectin isolated from <i>Citrullus lanatus</i> and <i>Cucumis sativus</i> peels in tetracycline capsule formulation." Nigerian Journal of Pharmaceutical Research 19, no. 1 (2024): 37–46. http://dx.doi.org/10.4314/njpr.v19i1.4s.

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Background: The advent of science and technology has greatly enhanced the conversion of agro-industrial wastes into various value-added products to meet the demands of increasing population. The study evaluated the binding properties of pectin isolated from Citrullus lanatus and Cucumis sativus peels in comparison with carboxymethyl cellulose (CMC) and pectin BP in oxytetracycline capsule formulationsMethods: Pectin was extracted from Citrullus lanatus and Cucumis sativus peels using standard procedures. Extracted pectin was subjected to phytochemical, organoleptic and spectral analysis and th

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Chime, Salome A., Paul A. Akpa, Cosmas C. Ugwuanyi, and Anthony A. Attama. "Anti-Inflammatory and Gastroprotective Properties of Aspirin - Entrapped Solid Lipid Microparticles." Recent Patents on Inflammation & Allergy Drug Discovery 14, no. 1 (2020): 78–88. http://dx.doi.org/10.2174/1872213x14666200108101548.

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Background: Aspirin is a nonsteroidal anti-inflammatory drug that is very effective in the treatment of inflammation and other health conditions, however, it causes gastric irritation. Recently, researchers have developed patents (US9757529, 2019) of inhalable aspirin for rapid absorption and circumvention of gastric irritation. Objective: The aim of this work was to formulate aspirin-loaded lipid based formulation in order to enhance oral bioavailability and inhibit gastric irritation. Methods: This solid lipid microparticles loaded with aspirin (SLM) was formulated by a modified cold homogen

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